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  • 12 Monkeys: Dr. Peters, who is plotting to unleash a virus that will destroy humanity.
  • 48 Hrs.: Albert Ganz, an escaped prisoner killing anybody between him and his hidden loot.

    A 
  • The Afflicted: Maggie, a religious fanatic tormenting her children.
  • Alice in Murderland: Kat Glass, who has donned a Jabberwock disguise and started killing her sorority sisters.
  • Alice, Sweet Alice: Mrs. Tredoni, who kills anybody she feels is a sinner.
  • The Alien franchise has the titular creatures, or Xenomorphs, with each movie featuring several different beasts though there are few human antagonists with Weyland-Yutani and the Engineers serving as Greater-Scope Villain:
    • Alien: The Xenomorph killing the crew.
  • Alien Outlaw: The unnamed leader of a trio of aliens who came to Earth for some recreational murder.
  • American Assassin: Ghost, a former Orion operative turned terrorist who plans to start a nuclear war.
  • American Beauty: Colonel Frank Fitts, who spends the entire film abusing everybody around him and eventually commits murder to hide his repressed sexuality.
  • American Justice: Sheriff Payden, who makes his police department into a protection racket.
  • American Nightmare: Jane Toppan, a madwoman who kills people with their worst fears.
  • Most of the Amityville films have the haunted house or an object from it acting as the main villain, The Amityville Curse has a human villain: Frank, who murdered his illegitimate father in the past, memories of which are driving him to kill again.
  • Army of Frankensteins: Captain Robert E. Walton, a Confederate officer seeking to use the Frankensteins to win the Civil War.
  • Audition: Asami Yamazaki, a Yandere willing to torture those who play with her feelings.
  • Axeman: The Axeman of Cutter's Creek, a large man who kills people for fun.
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    B 
  • Back to the Future:
    • Back to the Future Part II: Biff Tannen. An elderly Biff from 2015 steals the Delorean time machine and gives an almanac of sporting events from 1950-2000 to his younger self from 1955. Biff in this new timeline uses the information to make himself rich and famous, turns Hill Valley (and possibly the state of California and other places) into a Crapsack World, and murders George McFly in 1973, forcing Marty’s mother Lorraine to marry him. After Doc and Marty go back to 1955 to retrieve and destroy the almanac, the Biff from that time period serves as a Climax Boss.
    • Back to the Future Part III: Buford "Mad Dog" Tannen, an outlaw ancestor of Biff’s. He kills Doc in a timeline of 1885, and Marty’s plot line is preventing “Mad Dog” from killing Doc.
  • The Bagman: Randy Joyner, a scumbag who beat a disfigured teen to death and will do anything to cover it up when a sack-masked slasher comes to avenge him.
  • Banshee!!!: The banshee, which got released from its watery prison and immediately went on a rampage.
  • The Barbarians: Kadar, an Evil Overlord who enslaved a peaceful tribe.
  • Barbarella: Durand Durand is threatening the universe with an innovative weapon he created; he fled Earth and Barbarella's mission is to find him and bring him back. Later it turns out he wants to use his weapon to conquer the universe.
  • The Burton-Schumacher Batman films:
    • Batman (1989): The Joker. Originally a mob hitman named Jack Napier, he falls into acid and letting his impulses loose. In this series, The Joker has an added connection to Bruce Wayne: he murdered Bruce's parents.
  • Bedeviled: Mr. Bedevil, a demon haunting people through a phone app.
  • Belzebuth: Belzebuth, AKA Satan himself, who is committing mass murders of children to try and prevent the Second Coming.
  • The Black Belly of the Tarantula: Mario, a sadist who paralyzes women with tarantula hawk wasp venom so he can torture them to death.
  • Black Belt Jones: Don Steffano, The Mafia boss who killed Jones' master.
  • Black Butler: Lady Hanae Wakatsuki, a hooded figure plotting a chemical terrorist attack.
  • Black Christmas (1974) Billy, a maniac killing his way through a sorority house.
  • The Black Cobra: The unnamed leader of a group of anarchist bikers, who leads them in pursuing a witness to their crimes.
  • Black Dynamite: President Richard Nixon, who intends to shrink the penises of every black man in America to vent his own sexual insecurities.
  • The Black Room: Baron Gregor de Berghman, who killed his brother and immediately became a tyrant.
  • The Black 6: Thor, a biker gang leader who kills black men over interracial relationships.
  • Black Sunday: Princess Asa Vajda, a wicked sorceress brought Back from the Dead as a vampire to avenge her execution.
  • Blade Runner: Roy Batty, the leader of a group of Replicants who want to extend their lifespan.
    • Blade Runner 2049: Niander Wallace, wanting to figure out the secret that allows Replicants to give birth, which would make for more "authentic" Replicants, but the main threat is Luv, assigned by Wallace to hunt down anyone who could stop him.
  • Blade: Deacon Frost, an upstart vampire who wants to resurrect the Blood God so bloodsuckers can rule the Earth.
  • The Blob (1958): The Blob, who falls to the Earth and immediately starts absorbing people.
    • The Blob (1988): Dr. Christopher Meddows, who created the Blob and is willing to sacrifice an entire town to test it.
  • Blood & Donuts: The unnamed crime boss harassing Earl.
  • Blood Cult: Dr. White, leader of a cult that is trying to resurrect its dog god.
  • Blood Feast: Fuad Ramses, a madman who butchers women to awaken the goddess he worships.
  • Blood Junkie: Andy, a young boy who decides to murder his sister and her friends during a camping trip.
  • Blood Monkey: Professor Conrad Hamilton, an anthropologist willing to do anything to study the apes.
  • Blood of Beasts: Sven, a viking warrior plotting a coup against his chieftain.
  • The Brain (1988): The Brain, an alien that intends to consume the independent thoughts of all of humanity.
  • Braindead Vera Cosgrove, Lionel's abusive mother who ends up being Patient Zero of a zombie plague.
  • Bram Stoker's Dracula: Count Vlad Dracula, a vampire lord relentlessly pursuing the reincarnation of his lost love.
  • Brotherhood of Blades: Zhou Jhingzhong, who masterminded a coup attempt in order to take over the Imperial Assassins.
  • Brotherhood of Death: Harold Turner, The Klan's local Grand Cyclops, who uses his position as County Attorney to suppress the black population's vote.
  • Bubba Ho Tep: King Amen Ho-Tep, a Mummy eating souls in a nursing home.
  • Bubba the Redneck Werewolf: The Devil, real name Bladderick Rasputinstein the Third, Jr., who caused Bubba's lycanthropy curse and seeks to cause chaos in Cracker County.
  • The Burning: Cropsy, a disfigured madman out to kill everybody to avenge his injuries.

    C 
  • Cannibal! The Musical: Shannon Bell, who is driven mad by hunger and a brain infection and starts killing his traveling party.
  • Carnage Road: An unnamted old man who manipulated his war buddy to become a killer as revenge for America's treatment of Vietnam veterans.
  • Carnival of Souls: The Man, a being that's been haunting Mary since her car crash so he can claim her soul.
  • Casablanca: Major Heinrich Strasser, Nazi governor of occupiedCasablanca.
  • Cast a Deadly Spell: Amos Hackshaw, a warlock willing to sacrifice his own daughter to the Old Ones to start the apocalypse.
  • Cloud Atlas: Most characters played by Hugo Weaving. He's a murderous hitman in 1973, an oppressive battleaxe nurse in 2012, a politician who signs Sonmi's death warrant in 2144 and in 2321, he's literally the devil. Characters played by him that are not be big bads of their era are still villainous to a degree, being a slave trader in 1849 and a Nazi in 1936. The big bad for 1849 goes instead to the greedy Dr. Goose played by Tom Hanks, while in 1936 there is no clear antagonist - most of the drama comes from the relationship between Frobisher and Sixsmith.
  • Cold Sweat: Colonel Ross, who was betrayed to prison by our hero and kidnaps his family in revenge.
  • Collateral: Vincent, a Professional Killer who is hired by a drug lord to murder the witnesses and lawyers to the drug lord's trial.
  • Collateral Damage: Claudio Perrini, a terrorist willing to destroy anybody to get the Americans out of Columbia.
  • The Conjuring:
    • In the first film, Bathsheba Sherman, a Satanist who sacrificed her baby and hanged herself after being discovered who wants to possess living mothers to sacrifice their children too.
  • Conquest: Ocron, a mad queen who rules a wasteland with an iron fist.
  • Contagion: The titular contagion itself, which causes a global pandemic, is the ultimate source of all the conflict in the movie (the conflict that exists between humans, as opposed to between humans and the disease, is still indirectly caused by the disease).
  • Criminally Insane: Ethel Janowski, a madwoman who kills anybody who gets between her and food.
  • The Crow: Top Dollar, who is not only responsible for ordering the attack that led to the deaths of Eric Draven and Shelly Webster, but came up with the debauched chaos of Devil's Night in the first place.
  • C.S.A.: The Confederate States of America: Each John Ambrose Fauntroy, as they head a family dynasty that's considered "American royalty" and are responsible for all the political and cultural direction undertaken by the Confederacy. For instance, it was the influence of the first John Ambrose Fauntroy that resulted in the North embracing slavery.
  • Cure: Kunihiko Mamiya, a hypnotist who makes other people commit incredibly brutal murders.

    D 
  • Death on Demand: Sean McIntyre, an insane mountaineer who killed his family and then himself, then was summoned Back from the Dead in the middle of a livestream decades later.
  • Death Screams: Casey, who kills teenagers who have sex under a misguided sense of morality.
  • Death Wish series:
  • Death Wish (2018): Knox is the leader of the thugs who murdered Paul Kersey's wife in a home invasion.
  • Deathgasm: Aeloth the Blind, a demon king set upon a small town by a mysterious hymn.
  • Demolition Man: Simon Phoenix, an anarchistic terrorist let loose on a pacifist future.
  • Demon Hunter (2005): Asmodeus, the Demon of Lust, who wants to father an army of half-demons to conquer the world.
  • Demon Hunter (2016): Escharin Falstaff, the Evil Sorceror who set Barker on her path of vengeance and now plots to claim her soul.
  • Dogma: Azrael, who manipulated Bartleby and Loki into attempting reentry into Heaven, which would overrule the word of God and unmake existence.
  • Don't Go in the Woods: The unnamed maniac killing anybody entering his woods.
  • Don't Kill It: An unnamed demon on a body-jumping killing spree.
  • Don't Open Till Christmas: Giles Harrison, who kills men dressed as Santa to give his brother an interesting case.
  • Doom: Dr. Carnack, who is responsible for the experiments that caused the outbreak in the first place.
  • Dragonheart: King Einon, a tyrant who uses his seeming immortality to commit whatever atrocities he pleases.

    E 
  • Edward Scissorhands: Jim, Kim's scummy boyfriend who grows increasingly violent in his jealousy.
  • Enemy Mine: Stubbs, an illegal mine owner who enslaves aliens.
  • Escape from New York: The Duke, who has taken control of the New York City prison and inholding the President hostage.
  • The Evil: Satan, the evil force trapped in the house.
  • Evil Dead: The Evil Force controlling the Deadites.
  • Evil Laugh: Sadie Burns, who is killing everybody to prevent the orphanage where he son committed mass murder-suicide from reopening.
  • Excalibur; Morgana le Fey, Arthur's half-sister who uses black magic and feminine wiles to destroy Camelot.

    F 
  • Faust: Mephisto, who tempts Faust into giving up his soul on a bet with an angel.
  • Fire with Fire: David Hagan, a neo-Nazi gang leader pursuing a witness to his crimes.
  • First Knight: Malagant, who seeks to overthrow King Arthur and become Camelot's ruler.
  • Fist of Legend: General Fujita, the Imperial Japanese officer who had Chen Zhen's master killed.
  • Frankenhooker: Jeffrey Franken, a Mad Scientist butchering prostitutes to make a new body for his dead wife.
  • Frankenstein's Army: Dr. Viktor Frankenstein, grandson of the more famous doctor, who has been experimenting to make automatons for the Nazis but secretly has his own agenda.
  • Freeway: Bob Wolverton, a Serial Killer who picks Vanessa up early in the film and tries to ruin her life when she injures him in self-defense.
  • Fright Night (1985): Jerry Dandrige, a vampire who lives next to the protagonist and seeks to feed on people around their neighborhood.
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    G 
  • The Galaxy Invader: Joe Montague, who is trying to kill an innocent alien for profit and horribly abuses his family.
  • Galaxy Quest: General Roth'h'ar Sarris, the leader of a campaign to hunt the Thermians to extinction.
  • Gangster Squad: Mickey Cohen, a psychopathic gangster imposing a stranglehold on Los Angeles through illegal business and prostitution. The titular squad is formed to counter him.
  • The Godfather: Don Emilio Barzini, the man who ostensibly keeps the Five Families together, but is secretly plotting to topple them all.
  • Goth (2003): Goth, a madwoman who believes that true goth culture is indulging in as much hedonistic rape and murder as possible.
  • Graduation Day: Kevin Badger, who is slowly picking off the track team he blames for his girlfriend's death.
  • Grabbers: The male grabber leads the alien colony invading a small Irish village.
  • Grave of the Vampire: Charles Croydon, the vampire who raped the hero's mom and is responsible for his half-undead curse.
  • Gutterballs: Steve, leader of the gang rape that started the killings.

    H 
  • Hack-O-Lantern: Grandpa Drindle, a Satanic cult leader manipulating his son into becoming his successor.
  • Hatchet: Victor Crowley, an Ax-Crazy spirit terrorizing the New Orleans swamps.
  • HauntedWeen: Eddie Burber, a psycho killing frat bros in his childhood home.
  • Havenhurst: Eleanore Mudgett is the landlord of an apartment building where people with various addictions and vices can stay to recover. If they fall back into their problems, however, Eleanore has them dropped into the basement, where they're sadistically tortured to death by her sons.
  • Hawk the Slayer: Voltan, Hawk's brother, who killed their father for the Mindstone and is now holding a bunch of nuns hostage to do the same.
  • High and Low: Ginjiro Takeuchi, a kidnapper of children.
  • High Noon: Frank Miller, a gang leader who has been released from prison and is out for Marshal Will Kane's blood.
  • The Hitcher: John Ryder, a hitchhiker who kills those who pick him up.
  • Housebound: Dennis, who committed the plot-driving murder.

    I 
  • I Come in Peace: Talec, an alien drug dealer who sells human spinal fluid.
  • I Sell the Dead: Samuel Murphy, the patriarch of a family of ruthless grave robbers.
  • Idiocracy: The unnamed CEO of Brawndo, an energy drink company that is causing the collapse of the ecosystem by feeding the plants their product instead of water. However, unlike many Big bads, he isn't malicious, as like the rest of humanity in this setting, he's really, really stupid.
  • Idle Hands: The unnamed evil force, which possesses lazy men's hands to kill for it.
  • I'm Gonna Git You Sucka: Mr. Big is in charge of all crime in the city and he doesn't like people asking questions about him. When they do, he sends his thugs around to shut them up.
  • The Innkeepers Madeline O'Malley, the ghost haunting the hotel.
  • Innocent Blood: Sal "the Shark" Marcelli, a Mafia don who's been turned into a vampire.
  • The Invitation: Dr. Joseph, a cult leader who believes the best solution to grief is murder-suicide.
  • Ip Man: General Miura, the leader of the Japanese forces occupying Ip Man's village and the one who challenges him to a martial arts match.
  • Ironclad: King John, who seeks to bring England back under his rule after reluctantly signing the Magna Carta.

    J 
  • Jaws: The shark terrorizing the beaches of Amity.

    K 
  • Kick-Ass: Frank D'Amico, who is responsible for much of the crime in the city as well as being the one who framed Big Daddy and sent him to jail.
  • King Kong (1933): King Kong, a giant gorilla who terrorizes a native tribe and later New York City.
  • Kung Fury: Adolf Hitler, the Kung Fuhrer, who has come forward in time to battle Kung Fury for his power.
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    L 
  • Legend (1985): The Lord of Darkness, who wants to kill all the unicorns and consume the world in ice.
  • Legend of the Red Reaper: Ganesh, a depraved demon king hunting down his daughter.
  • Little Evil: Satan, who plots to ascend to the Earth by having his son sacrificed.
  • The Lizzie McGuire Movie: Paolo Valisari, a young and charming pop star who uses Lizzie's resemblance to his ex girlfriend/singing partner to ruin her reputation.
  • The Lord of the Rings: The Dark Lord Sauron is the primary driver of the plot. As the trilogy begins, he is poised to conquer all of Middle-earth, and his victory will become assured if he captures the One Ring. He kick-starts the plot by sending the Ring-Wraiths to take the Ring from Frodo, he corrupts Saruman into attacking Rohan and kidnapping two of the heroes in the second film, and he musters a massive force to attack Gondor (and is mentioned in dialogue to be attacking all other good-aligned nations) in the third film. The plot isn't resolved until the Ring is destroyed, killing Sauron and leaving his forces leaderless and easily routed. In addition to him, Gollum, the previous bearer of the Ring before Bilbo, acts as a more direct threat to Frodo. Though while Gollum is able to be in an Enemy Mine with Frodo and Sam throughout the second film and guide them to Mordor in the third, his possessive desire to reclaim the Ring begins to take a hold as they get closer, and he betrays them when they are there, actually succeeding in grabbing the ring via biting Frodo's finger off, if only to fall into Mount Doom with it.
    • The Hobbit, as a prequel to The Lord of the Rings, has two major enemies that Bilbo, Gandalf, and the Thirteen Dwarves must face. The main driving force of the conflict is Smaug, the dragon that took over Erebor and drove out the dwarves to claim their gold and jewels. However, as Smaug doesn't directly encounter the dwarves yet, the first film in the series, The Hobbit: An Unexpected Journey sees Azog the Defiler, whom killed Thorin's grandfather Thror, and whose orcs took over Moria, Spared by the Adaptation with a severed arm courtesy of Thorin, and as the most direct threat faced in the film, pursuing the main characters throughout the film and nearly succeeding in catching them. In the second film, The Hobbit: The Desolation of Smaug, Azog remains in pursuit early in the film, before being revealed to answer to The Necromancer, and therefore stays at Dol Goldur while his son Bolg continues the pursuit of the heroes. The Necromancer turns out to be Sauron, planning a war long before the one that took place in The Lord of the Rings. The dwarves and Bilbo eventually arrive at Erebor, and they finally confront Smaug for the first time, though they are unable to kill him and prevent his attack on Lake-town. Smaug winds up a Disc-One Final Boss in the final film of the trilogy, The Hobbit: The Battle of the Five Armies, killed by Bard, and Sauron is promptly exiled to Mordor by the combined forces of Galadriel, pre-Face–Heel Turn Saruman, and Elrond, leaving Azog to lead the invasion over Erebor and confront the heroes one last time.
  • The Lost Boys: Max, a vampire pack leader trying to corrupt a family into joining him.

    M 
  • Mars Attacks!: The Martian Emperor, who has ordered his planet's armies to destroy the Earth.
  • Mean Girls: Regina George, the Alpha Bitch of the school, who controls the social scene with an iron fist.
  • Men in Black: An unnamed bug alien seeking a powerful energy source to win an intergalactic war.
  • Miami Connection: Yashiro the White Ninja, who is trying to take over the Miami drug trade.
  • Monsieur Verdoux: Henri Verdoux, who marries and murders women to care for his family.
  • Mortal Engines: In a change from the novels, Thaddeus Valentine is the sole example here. He plans to recover MEDUSA and use it on the rest of the world to make London pre-eminent, murders Pandora and Crome when they try to stand against him and is ultimately responsible for the devastating attack on Shan Guo.
  • Mutant Girls Squad: The Prime Minister of Japan, who has started a campaign of genocide against a bunch of mutants.

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