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"Of course! Don't you know anything about science?"
Each scientist that is housed here is given their own private lab to do their experiments and research.
Notoriously known for the hundreds and hundreds of glass beakers that contain colorful liquids that are scattered all around. Nobody knows what they are, but they make the house look more science-y.
Storm clouds have often appeared around the house to be used as an alternate energy source for any of the experiments that are conducted.
Has close ties to the House of Machinery and Technology as some members are part of that house and they sometimes collaborate with one another. The same also applies to House of Knowledge for research purposes.
Is the opposite spectrum of the House of Magic and Sorcery. Some members tend to rub the others the wrong way thanks to the "magic vs. science" fiasco. Of course, there are also those that use these hand in hand, and reactions from both Houses are mixed on this.
Forbidden to ever clone Hitler. Or create a robot Hitler. Or clone Hitler and then turn him into a robot with a jetpack. You'd be surprised how often this happens.
Philanthropists of Benevolent Science

- Lesser God
- Symbol: His Glasses
- Theme Songs: Dexter's Laboratory Theme
and Outro
- Alignment: Neutral Good with some moments of True Neutral
- Portfolio: Adorkable, Smart and Badass, Smart In Science But Not In Everyday Stuff, Expressive Eyewear, Science Hero, Unknown Accent, Short Smarty, Everything In The Name Of SCIENCE!, Science Ace
- Domains: Science, Technology, Genetics
- Allies: The Ghost Planet Staff, Twilight Sparkle, Tony Stark/Iron Man, Victor Stone/Cyborg, KND, Reed Richards/Mister Fantastic, Krim Steinbelt, Blossom, ICEY
- Rivals: Mandark, Tabane Shinonono
- Enemies: FUSE, Brainiac, GLaDOS, Dr. Ivo Robotnik, Ultron, Ryoma Sengoku/Kamen Rider Duke
- Hero Worship: Superman, Captain America, The Hulk, Thor, Gary Gygax, Dave Arneson
- Annoyed With: Pinkie Pie, Taokaka
- Family: Dee Dee
- Even though nearly everybody knows about his "secret lab", he still remodeled his temple after his old room with hidden passages that leads to his underground lab.
- Many in the House of Technology are astonish that someone as young as Dexter could build so many robots, machines, and other experiments. Both Tony Stark and Reed Richards have been thinking of making him their protégée.
- Has begun construction on his own power armored suit after witnessing the amazement of Tony's own Mark suit. He was amazed he was able to build his Mark I with nothing but scraps.
- Has been disturbed at the number of evil robots and machines like Brainiac, Ultron and GLaDOS running around the Pantheon. Interesting enough, the last one has even cause his own Computer to express the unknown emotion of hate
- Has started a rivalry with eccentric IS builder Tabane Shinonono. His reason for the rivalry is because someone that flaky can't be a genius builder. Amusing enough, any matches between the two are just comical in nature. Like when the two played chess, with robots, IN SPACE.
- When he first encounter the Mane Six, he thought they were the same crazy ponies that attacked his sister. The misunderstanding was quickly cleared up and Dexter has even befriended Twilight Sparkle because of her scientific approach with magic. He has even try incorporating magic energy as an alternate fuel for his machines.
- Even though he has no hostility towards Mane Six, he still finds Pinkie Pie annoying with her high energy personality. Though, he does find her homemade cupcakes delicious.
- He also finds Taokaka just as annoying. With her constantly finding ways to enter his laboratory and asking his questions on what he is doing. Thankfully for his lab, she doesn't destroy everything on sight like Dee Dee.
- Had a "fan-gasm" when he first met Dungeon & Dragons creators Gary Gygax and Dave Arneson. The same goes to many of the superheroes like Superman, Captain America, The Hulk, and Thor who resemble The Justice Friends.
- Dexter is unfortunately in Santa's permanent Naughty List after he attacked Santa Claus and beat up his reindeer.
- Of all of the people that ascended, it was his sister Dee Dee and the first thing she did was enter his laboratory without his permission. Dee Dee is glad to be with her baby brother but Dexter is not very amused about it. Despite that, he shows some relief that Dee Dee is finally here.
- He often hangs out with Blossom, bonding over their interests in superheroes and academics. Needless to say, many deities think they're absolutely adorable together. These comments always make the two of them blush.
- Nearly had a mental breakdown when he found an alternate universe in which his sister Dee Dee was killed in a crossfire between Mandark and himself. It got worst when he saw ANOTHER universe in which he himself has turned evil with the implication he killed Dee Dee.
- Also present in the House of School.

- Lesser God
- Symbol: A flask of Chemical X
- Alignment: Lawful Good
- Portfolio: Those Eyebrows, Truly Single Father, Literal Fatherly Scientist, Great Parents, Standard '50s Father, Reasonable Leaders, Dislikes Cats, Team Dad, Nice Guy That You Don't Mess With, Scientist In Many Fields
- Domains: Fathers, Science, Chemicals, Superheroes
- Allies: The Powerpuff Girls (his daughters), Bunny, The Powerpuff Girls Z, Nibbler, Mary Poppins, Carl and Ada Clover, Son Chichi, Yui, Astro Boy, Samurai Jack, Kotetsu T.Kaburagi, Krim Steinbelt
- Friendly Rivalry with: Dr Thomas Light, Dexter
- Good Counterpart to: Relius Clover
- Enemies: Mojo Jojo, (former lab assistant), HIM, Silico, Princess Morbucks, Lady Tremaine, Raynare, Felix, Gharnef, Dr Wily, Arachne, Ungoliant, Father, Aku, Tenjuro Banno, Ryoma Sengoku
- Opposes: All ascended cat and spider gods, the House of Crime and Transgressions
- Opposed by: Homer Simpson
- Professor Utonium is a brilliant scientist in the once crime-ridden city of Townsville. Hoping to bring some happiness and comfort into his life, he planned to create the perfect little girls using sugar, spice and everything else. An accidental dose of Chemical X resulted in the girls coming alive with superpowers, becoming the Powerpuff Girls. Though artificial creations, the Professor treats them like his biological daughters and loves them dearly. He and the Powerpuff Girls were glad to meet each other in the pantheon.
- Back in the day, Mojo Jojo used to be a troublesome assistant chimp called Jojo. The two have a rather complicated relationship, and was the one who broke his vial of Chemical X which resulted in both the girls having powers and Mojo Jojo's super-intelligence. Because of this he's also the girls' "father", but it's only brought up to aggravate him.
- His first name is unknown, so people usually refer to him by the Professor. According to one source his first name is Drake.
- He is essentially the Good Counterpart to Relius Clover. The two are expert scientists and fathers, however, while the Professor treats his creations as family, Relius sees his own family as tools for experimentation. He's expressed disgust towards the truly single parent Father for his treatment of the Homunculi, and considers the fact they're aspects of himself a sign of immense self-loathing. In general, he isn't a fan of cruel parents or evil scientists. Being in the same house, he's put his focus on Dr. Wily. The most positive thing he can say about the man is that he's got some odd fondness for his creations Bass and Zero, but it doesn't justify his actions or the psychopathic Omega.
- There isn't a Mrs. Utonium, something of which he often feels lonely about. He once dated Sedusa, who used him to stop the Powerpuff Girls' heroism. This experience has led him to go against gold diggers and horrible girlfriends like Lady Tremaine and Raynare.
- The Professor is a very passionate and loving father, and is determined to raise his daughters the best he can. However, he can get rather overprotective of them, such as setting up elaborate situations to teach them morals. And the less said about his Dynamo mech, the better. Often spends time conversing with Son Chichi. Like Utonium, she can get a tad obsessive about protecting her incredibly powerful children and trying to raise them. Both are deeply respected by and deeply care for their kids, though. Has been trying to protect artificial kids out of his fatherly instincts, such as Yui and Astro Boy. He does sometimes cause trouble for Astro Boy, however, though this is just because he's worried he might try to date one of his girls.
- Looks an awful lot like Samurai Jack. He believes that the former is an ancestor of his, and has offered his assistance with the girls to stop Aku. Is a big fan of silent movies, pancakes and golf. He tries to avoid not getting too obsessed over golf anymore, as it led the Powerpuff Girls to steal a perfect set of clubs to help out. He's tried to be a superhero or fighter in his own right, but often needs his kids to save him.
- Is a brilliant inventor, having developed technology such as time travel, body switching machines and containment fields. However, his greatest inventions were accidental or the result of some mistake, which has given him some angst. The girls have managed to make him feel better by pointing out numerous great inventions like penicillin were accidental in origin. He's making more progress working with fellow kind-hearted scientists and inventors. He has a Friendly Rivalry with both Dr. Light and Dexter. With Dr. Light, they're very similar in attitudes to their creations and kind fathers, but still wish to prove to one another who's the best. With Dexter, he's the other famous Cartoon Network scientist.
- His experiences with Dick Hardly lead him to dislike people like Felix, and has warned Gharnef to back off after trying to steal his Chemical X. These experiences also lead him to try and protect Kotetsu T Kaburagi so he won't be exploited. Naturally, he's no fan of unscrupulous scientists and inventors like Ryoma Sengoku.
- Does not like cats. He was mind-controlled by one, and as such cannot trust them or let any near him. It's this distaste that broke his relationship to Ms. Keane. At the very least, it led to him getting along with Nibbler who agrees most cats are shifty, devious creatures. He's terrified of spiders in any form, which leads him to steer clear of the House of Insects(and insists that since they're arachnids, they shouldn't be in that house). He's not sure whom to be more frightened of; Arachne, mother of spiders or Ungoliant, the abominable arachnid. The Powerpuff Girls are doing their best to hide the fact that the Overdeity Chakravartin has his Golden Spider Form.
- In spite of his arachnophobia, even he thinks Billy's fear of spiders and treatment of his friendly spider son goes too far. Generally, he doesn't like the boy due to his extreme stupidity. He's also accepting of Peter Parker due to being merely spider-themed rather than an actual spider.
- Given he had the chemical knowledge to create the perfect little girls, one would imagine that he is a decent cook. And they're right... unless it's about chili, which he cannot cook for his life. During the pantheon's chili cook-off, Homer Simpson was on the scene to judge the participants. When he tried the Professors', Homer had to drink way more beer than before and passed out drunk, but not before declaring it "the worst chilli of all time". He's sworn to get back at the Professor for the awful taste. He did manage to make a better chili next time with Chemical X, however the resultant methane it gained a life of its own and became homicidal. It took the Kid to save the day from an exceedingly ignoble end.
- Tries to insist to the Powerpuff Girls he likes liver and onions, so as to get them to eat it. In truth, he hates the stuff and wants to come off as more adult.
- Can be seen helping out other good-aligned dads in the House of Fathers.

- Lesser God (Intermediate when he uses the Bruce Juice serum)
- Symbol: His Nerd Glasses
- Theme Songs: "As Days Go By"
or "Do the Urkel Dance"
- Alignment: Lawful Good
- Portfolio: Nerds, Science Hero, Butt Monkeys, Gadgeteer Genius, having a Geek Physique, Breakout Character, going home because he doesn't have to take this
- Domains: City, Invention, Sci-Fi
- High Priest: Leo Dooley
- Followers: Alex Wilder, AJ, Nils Nielsen, Ethan Bank, Andre the Black Nerd
- Heralds: The Winslow family, especially Carl (his Parental Substitute), Eddie (his best friend) and Laura (his wife).
- Allies: Albert Einstein, Mystery Inc., Melvin Fern/Toxie, Mobius, The New Day, Pepe Le Pew, Professor Julius E. Kelp and Professor Sherman Klump
- Odd Friendship with: Sonic the Hedgehog, Bruce Lee, Snoop Dogg
- Business Rival: Randy Marsh
- Fears: Slappy the Dummy
- Stev Urkel's ascension in the pantheon was a memorable one. It was an ordinary day when suddenly there was a large explosion in the House of Science. Many had wondered what on earth was going on as they gathered. When the smoke cleared from the debris, Steve was shown as a new invention of his had malfunctioned and he had only one thing to say.
- Urkel: Did I do that?
- Was originally a follower of Milhouse, until it was realized that Milhouse was not a nerd, 'cause "Nerds are Smart", at which point he deposed his former master by knocking him out as Bruce Lee. Bruce himself in the House of Combat doesn't know what to make of this serum.
- Has caught the interest of the Council of Shadows over his Bruce Juice serum.
- Tries his very best to get away from Captain Hammer due to the latter's viewpoint of see all nerds as evil.
- Urkel has actually built some crazy devices for his mundane sitcom world, such as a time machine or cloning device. The House of Technology was going to welcome him with open arms, until they noticed how destructive he could be, and how dangerous his prototypes were.
- Surprisingly enough, he's actually able to play basketball, and will be seen on the court in the House of Sports on rare occasions.
- His Sexier Alter Ego, Stephan Urquelle, has sometimes been seen in the Pantheon, minding his own business. Being a complete clone of Steve (who later decided to permanently switch to Stephan), he's at the same power, technically making him a god just the same as Urkel. Though he doesn't have a title or any authority, this doesn't bother him.
- When his voice is at its least nasally (or any time Stephan talks), some people can swear that they hear Sonic's voice.
- People were surprised that Steve got into the marijuana business and brought in Snoop Dogg to endorse his new product, Purple Urkel, in both the mortal realm and in the Pantheon
. Naturally, Randy Marsh sees Urkel as a new competitor to his Tegridy Farms and is working around the clock to outsell the Purple Urkel.
- Loves his cheese, and when not in The House of Science he can be found at The House of Food sampling and trying out all types of cheese along with Monterey Jack, though even he can find the Rescue Ranger's love of it unnerving.
Evilutionists of Mad Science

- Intermediate God. Greater God (as the Mesomonster).
- Symbol: His dinosaur head
- Alignment: Neutral Evil
- Portfolio: Trying to Bring Dinosaurs Back And Turn Humans Into Them, Badass Longcoat, Agony Beam/Mind Rape, Creepy Monotone, Dinosaur Person, Nothing Funny About This Guy, Mixing Three Things Together to Create Monsters, Bad Boss, Really Does Believe He Is Doing The Right Thing, Canon Foreigner, The Evil Side of Anton Mercer, Separating Himself From His Other Self
- Domains: Villains, Evolution, Dinosaurs, Separated Evil Sides
- Heralds: Triptoids, Tyrannodrones and all his chimera monsters.
- Allies: Tenjuro Banno, The Psycho Rangers, Ryoma Sengoku, the rest of the Demonic Legion, Albert Wesker, Trakeena, Neo Cortex, Vanitas, Bernkastel, Dark Link, Fecto Forgo
- Enemies: Dr. Tommy Oliver, the Mighty Morphin' Power Rangers, Power Rangers Jungle Fury, Torin, Grimlock, rest of the Toku Base Bragigas, Rexie, Rodan, The Gang of Seven, Chomper, Godzilla, Crash Bandicoot, Anguirus, Baragon, Asuka Langey Soryu/Shikinami Langey, Rika Furude, Ventus
- Opposed by: Kabutops, Omastar, Aerodactyl, Red Genesect
- Interested in: The Indominus Rex, Gwangi, Riptor, Sharptooth, MechaGodzilla
- Opposes: Beerus, The Lich
- Originally a member of the Demonic Legion, he became the first Power Rangers villains from there (if one doesn't count the Psycho Rangers) who managed to ascend into the Pantheon proper.
- Mesogog has an interesting idea for a plan. He sees that dinosaurs possess much better DNA than humans, thus believing that what he should do is revert the Earth back to the age of dinosaurs and turn all humans into reptilians creatures like he is.
- Note that He really does this is for the better of the world, even his actions are rather crude. While this doesn't make him any less villainous than other Power Rangers villains (in fact, he is way more intimidating than the others), his motives aren't as least as blatantly evil as some of the other ones.
- Originally, he was a scientist called Anton Mercer who was experimenting on dinosaur DNA to help humanity, but him testing something he created created Mesogog as a different personality in him. However, Mesogog eventually was able to find a way to separate himself from Anton, becoming his own being.
- Due of this, he has some sort of alliance with Vanitas, Bernkastel and Dark Link, as all of them being the evil selves who managed to gain their own form. Though this makes him enemies with those whom he spawned from.
- With his ascension, he has come across many different kinds of still existing dinosaurs. This pleases him greatly and is indenting to use them in his plans. While some don't mind or care about him or his plans, most do find some offense to him. Most gods fear what he might do if he gets his hands on Godzilla's DNA.
- Notably, upon finding about the fossil Pokémon, he seems to be hatching new plans how to bring dinosaurs back. Most of them take offense, especially Red Genesect due of his past.
- Besides all this, however, he is rather annoyed by Barney the Dinosaur. He considers an insult to dinosaurs, but isn't bothered to do anything to him.
- Has heard many versions of how dinosaurs when extinct, though he doesn't really believe in most of them aside one where the asteroid what hit the Earth was bit of an accident. Doesn't mean he appreciates those who might have wiped them out.
- Besides Tommy Oliver, he has hatred forwards Torin as the Kyoryugers, understandably so, remind him of the Dino Thunder Rangers. And he is guessing that he won't be seeing the last of Kyoryugers yet.
- While their idea of the next stage of evolution might not match, he is still allies with Albert Wesker. They even share similar taste in fashion.
- While many Toku villains have ascended before him, he is one of few who can actually create monsters using the Geno-Randomizer, allowing him to combine three things to create a monster. And like any good Super Sentai/Power Rangers Big Bad, he can enlarge them thanks to Hydro-regeneration.
- Also, of the fellow Toku villains, he is most friendly with Tenjuro Banno and Ryoma Sengoku, both fellow scientist and with the former, villainous fathers. Though both of them are keeping sure that they don't get to his bad side. They know what happened to Lothor.
- While he has Mind Rape powers, he tends to use them on his minions to keep them in line. This is why Asuka(s) hate him so much.
- Spider- Man really doesn't like him as he greatly resembles Curtis Connors/The Lizard down to the point that the reason why he exists is due of a experiment creating a monstrous evil side to a person. Fortunately for Spidey, he doesn't need to worry about doing anything bad to Mesogog due of him being separated from Anton.
- Crash doesn't like him due of his plans reminding him of Dr. Cortex. Mesogog would hardly care about the rodent.
- In regards to his Mesomonster form, it is currently unknown if he can really take that form again after getting blasted away. While some deities mock him for that form not lasting long, he says that he never got a chance to show what it can do.
- Always talks like he's entirely perturbed. At the very least, he goes one step above some other reptilians and draws out non-sibilants.

- Intermediate God
- Symbol: A miniature of his Helletic Hojo
- Theme Song: Trail of Blood
- Alignment: Chaotic Evil
- Portfolio: Only One Name, Absolute Immorality in the Name of Mad Science!, Experimented on his unborn son, wife and even himself, Evilutionary Biologist And Open, "Drunk", and Obvious About It, Evil Bespectacled People, responsible for every bad thing that happened in his home realm, being absolutely made to be hated, Omnicidal Maniac, crossing lines even most villains won't, implausibly appealing, disliked even in Shinra, objectifies all his test subjects and speciments, lacks empathy, is Sephiroth's father, uploading his brain to hijack another main villain, killed Aerith's father
- Domains: Science, Insanity, Monstrosity, Being Hated
- Followers: Are you kidding? Nobody wants to end up being his next guinea pig. He's prone to using anyone available as a test subject, and since followers are the closest people available to any deity...
- Allies: Melkor, Ryoma Sengoku, Fabius Bile, Tenjuro Banno, SHOCKER, Cioccolata, Evolto
- Rivals: Albert Wesker and the rest of the GUAE Mutation Lair
- Enemies: It'd be easier to make a list of deities who aren't his enemies. For specifics, though, there's Cloud Strife, Tifa Lockhart, Aerith Gainsborough, Nanaki/Red XIII, The Suite Pretty Cures, Ada Wong, the entire House of Nature, Shiro Kanzaki, and all good parents in general.
- Opposed by: Nearly every single scientist in the Pantheon, including many of the evil-aligned ones (sometimes because they don't want competition from him)
- Special Relation: Sephiroth (his creation in a "parental" sense)
- For a long time, Professor Hojo went unnoticed for a long time, letting Sephiroth take a lot of flak of the villainy in Final Fantasy VII. However, due to his unhinged mind, he left Ryoma Sengoku's temple to wander on his own, mistook Hibiki Hojo/Cure Melody as his long lost relative along the way, kidnapped her, and tried to experiment what kind of power he can get from the Pretty Cure. Apparently, it involves forcing Hibiki to relive the traumatic event of losing her Fairy during the battle against Black Hole over and over again while being Strapped to an Operating Table. Eventually, his activities were discovered by Cloud, along with Tifa, Red XIII, and Aerith swiftly bringing him down, and even Hibiki pulled enough of her remaining unbroken spirit—helped by fellow Pretty Cure Kanade—to assist them.
- The ascended AVALANCHE members and the Suite Pretty Cures dragged Hojo to the Court of the Gods to petition his removal, but just like how Lightning Farron brought in the Dazzlings to do the same thing, Melkor came to the villain's defense, pointed out Hojo's use of his own family as part of his experiments, and offered him a place in the Pantheon as a God to represent that act as well as a place in his Mutation Lair. Eager to work his science, Hojo quickly accepted the offer.
- Ryoma Sengoku* , Tenjuro Banno, and SHOCKER (who wanted to employ him) also provided their support in this, and so Hojo was given a temple in the House of Science. For some reason, several members of the GUAE were consternated by this after the fact, though it could just be from how mad of a scientist Hojo is.
- Hojo later tried this scheme again with Satoko, but her many traps put a stop to that.
- For reasons known only to himself, Lord Chaos has one thing to say about Hojo... Even if for some reason the scientist shows capabilities as a Warrior, he won't choose him. He is above such monstrosity.
- Upon hearing upon what Professor Hojo had done to Sephiroth, Uncle Howee decided to pay him a visit for a proposition: Win a game of Hide-and-Seek, and he would deliver him one deity as a "test subject" of his choice, no questions asked. He leapt at the chance, only to see himself absolutely mauled by every scientist in the Pantheon who could attend, even the evil ones (well, the ones with better moral standing than Hojo). Howee declared him the loser and made him into a marionette for all the other Gods to rip apart. Let's just say many deities went upon a field day with him.
- One of his diabolical plans was to turn himself into a computer virus and corrupt the House of Technology. Fortunately, when he attempted this, he was quickly caught and stopped by Tron. The Grand United Alliance of Machines isn't amused with this either, having heard of him through Dr. Wily.
- Fabius Bile went over to Hojo's new temple and commented that not only does he like the cut of his jib, but is willing to teach him some new horrific things. Hojo gleefully took the offer of learning more.

- Intermediate God as a New Generation Rider (Lesser God as a Armored Rider, Borders on Greater God, after he became a cyborg and attaining the Dragon Energy Arms at the same time)
- Symbol: The Duke symbol and his Lemon Lockseeds.
- Alignment: Chaotic Evil (used to be Neutral Evil)
- Portfolio: Greater-Scope Villain, Admiring the Abomination, Absent-Minded Professor, Backstabbing Anyone for Power, Being an Ultra Hammy Sociopath, Committing Atrocities For Science!, Dragon with an Agenda, Excessively Cruel to Others, Failure to Understand the Concept of Friendship, Faux Affably Evil, Lacking Any Empathy Whatsoever, Manipulating Anyone to Get What He Wants, Obsessed with His Ambitious Goals of Becoming a God, Psychopathic Manchild, Dirty Cowards, 0% Approval Rating, Taking Narcissism to the Max, Lovingly Hated Villains, Breakout Villains, Returning from the dead as a cyborg, Asshole Victims
- Domains: Betrayal, Chaos, Depravity, Domination, Evil, Hate, Science, Technology, Godhood.
- Superior: Gen Urobuchi
- Followers: Dr. Stylish, Masahiko Minami, Doctor Psycho, Dr. Rotwang, Dr. Loboto
- High Priest: Nine Barthes
- Creations: Sengoku Driver, Genesis Driver, Lockseeds, Energy Lockseeds
- Allies: All Ascended Toku Villains and the GUAE Mecha Cohort, SHOCKER, the GUAE Trollkaiger (especially Enter, and Yuuki Terumi, Junko Enoshima and Monokuma), Johan Liebert, Nobuyuki Sugou/Oberon the Fairy King, Albedo Piazzolla, Ragyo Kiryuin, the Incubators, Orochimaru, Eliza and Neil Reagan, Ex, Professor Hojo
- Headbutting Villains With: Lord Djibril, Redyue
- Rivals: Houka Inumuta, Edward Richtofen
- Enemies:
- All Ascended Toku Heroes, including Kouta Kazuraba/Kamen Rider Gaim, Kaito Kumon/Kamen Rider Baron, Mitsuzane Kureshima/Kamen Rider Ryugen, Takatora Kureshima/Kamen Rider Zangetsu (Shin), Mai Takatsukasa, Hideyasu Jonouchi/Kamen Rider Gridon, Oren Pierre Alfonzo/Kamen Rider Bravo, Zack/Kamen Rider Knuckle, and Yoko Minato/Kamen Rider Marika, The Build Kamen Riders(especially Sento Kiryu/Kamen Rider Build)
- Others: All Heroic Gundam Deities (especially Aila Jyrkiäinen, Garrod Ran & Tiffa Adill, Sei Iori & Reiji, Team TRY Fighters, Setsuna F. Seiei, and Marida Cruz), All Ascended Pretty Cures, All Puella Magi (especially Madoka Kaname, Sayaka Miki, and Kyoko Sakura), Makoto Naegi, Hajime Hinata and Izuru Kamukura, Chiaki Nanami (Human) and Chiaki Nanami (AI), Komaru Naegi, Kenshiro, Satellizer el Bridget, Rana Linchen, Chiffon Fairchild, Elizabeth Mably, Shinji Ikari, Ichigo Kurosaki, Isaac Clarke, Peter Parker/Spider-Man, Commander Shepard, Kula Diamond, Hotaru Tomoe/Sailor Saturn, Kazuto "Kirito" Kirigaya, Asuna Yuuki, Shino Asada/Sinon, Yuuki Konno, Doraemon, Alisa Illinichina Amiella, Ryuko Matoi, Satsuki Kiryuin, Shirou Emiya, Illyasviel von Einzbern, Chloe von Einzbern, Tony Stark/Iron Man, Koro-sensei, Bulma Briefs, Gracia, Akane Tsunemori, Nana, Dexter, Akame and Night Raid, Gai Tatsugami, River Tam
- Evil Counterpart To: Shiro Kanzaki
- Opposes: Lock Dealer Sid/Kamen Rider Sigurd, Kougane/Kamen Rider Mars, Monaca Towa.
- Opposed by: Sou Fueki/The White Wizard, Tomoko Nozama, Homura Akemi.
- Ryoma Sengoku is an amoral scientist who has no concern about the lives of others, which he uses them as his test subjects for his research, just to achieve his goal of grasping the Forbidden Fruit in order to become a godly figure. He was first introduced as a close associate to Takatora Kureshima as they work in a secret project called the "Project Ark" while he's researching on the Helheim Forest which leads to the creation of Lockseeds and Sengoku Drivers. However, he made a point that he will fulfill his own ambition by betraying Takatora after he was distraught of Takatora's decision of saving humanity as a priority back in the past, before successfully usurped the Yggsdrasill Corporation for his own plans. Any doubt about his place was later put to rest after he leaked information of the political powers who were involved in Project Ark to the press, allowing him to pursue the fruit of knowledge as he pleased while the World Leaders took all the blame. After the destruction of the Over Lord Inves and his failed attempt to grasp the Forbidden Fruit completely, he finally met his end after receiving a vicious beatdown at the hands of Kaito Kumon, who became the Over Lord known as Lord Baron, and falling to his doom. However, he was revived by Megahex as a cyborg with the impression of "achieving his goal as a godly figure" until he is finally killed off by Takatora Kureshima in their final showdown.
- Although he died in two occasions, Ryoma seems to be satisfied after he found himself in the pantheon, believing that he became a real god. However, he's not the only one as most of his enemies from Zawame are also present was well. He also seems to be aware that he will gain alot of enemies with various heroes in the pantheon after he started his research on their capabilities while some of them just hates his guts for different personal reasons. For him, his death in the mortal world is just the beginning.
- His attitude as a Mad Scientist has made him an enemy to every good-aligned scientist as they cited all of his atrocities he made in the name of science, this is the reason why he got banned from the House of Technology in the first place.
- He also gained two rivals in the form of Houka Inumuta and Edward Richtofen, as the former is known of collecting data to improve the Goku Uniform is similar to his job of improving his inventions via data collecting while the latter is also a mad scientist who has the same psychopathic attitude just like him.
- After he heard the presence of the terrorist organization SHOCKER, he decided to join in their cause for world domination in order to analyze the data of all heroes in the Pantheon, especially the Kamen Riders, as a means to create a countermeasure against them. His role as a employed member of the organization is to create more Sengoku Drivers and Matsubokkuri Lockseeds to their Shocker Combatmen, which allows them to transform into Kurokage Troopers.
- While he quite gets along with his fellow SHOCKER employed members, he is not fond of working with Lord Djibril at all as he cited Djibril's idiotic actions have cost SHOCKER some battles against various heroes in the Pantheon.
- Ryoma handpicked Nine Barthes as his High Priest after Nine impressed him with the Embody System, an invention that would allow the controller to Mind Rape a subject to follow commands and increase the subject's reflexes. Needless to say, Ryoma's decision quickly made him Enemy No. 1 for Gunpla fighters Aila, Reiji, Sei, and Team TRY Fighters.
- Due to his association with Nine Barthes, Ryoma is willingly contribute his research to the Mecha Cohort to strengthen their robots for evil. Due to this, he became bitter enemies with Marida Cruz, and by extent, the rest of the Gundam Corps.
- He knows many of the Riders' tricks of the trade and adapts quickly to adjust, from installing hologram projections to providing a killswitch to prevent rivals from using a Genesis Driver to transform. Kouta and Takatora both warned the GUAG about Ryoma's cunning given how much grief he gave them.
- Ryoma's pursuit to becoming a god have put both Sayaka Miki, Shinji Ikari, Isaac Clarke, Ichigo Kurosaki, and Setsuna F. Seiei on full alert. Aware of the dangers of facing an opponent using the Genesis Driver, Isaac is working overtime to craft the weapons he, Ichigo, Shinji, Setsuna, and Sayaka, need to stop this dangerous threat.
- Ryoma is currently working on a universal kill switch that will destroy all transformation devices, even non-technological ones. Because of this, every transforming heroes and magical girls considers him a threat.
- Due to his desire to become a god by any means, he gets along with other deities with god-complex mentality like Albedo Piazzolla, Sosuke Aizen, and Orochimaru. Rumors that they are starting to work together to achieve omnipotent power so that no one would stand in their way.
- Mitsuzane will never forget the time Ryoma killed Mai behind his back after the latter manipulated him to kill Kouta. However at this point, he learned that Micchy managed to get out from the Purgatory after he managed to regain his good reputations among the Toku heroes. Ryoma will find a way to crush him if the right time comes.
- Ryoma really opposes Lock Dealer Sid and Kougane due to two reasons, as the former betrayed him in an attempt to claim the Forbidden Fruit for himself and the latter killed his alternate self from the soccer world after he broke the artificial forbidden fruit's seal.
- He is somewhat being opposed by Sou Fueki, Homura Akemi, and Tomoko Nozama, for three reasons: Fueki has a negative opinion regarding of his Lack of Empathy towards everything, Homura is just seemed not to like him for his pursue of becoming a god, and Tomoko sees him as no different to any evil riders in general.
- He became close allies with Johan Liebert, the Trollkaigers, Kyubey, Monokuma, and Junko Enoshima, due them having a mutual interest of seeing the likes of Madoka Kaname, Makoto Naegi, Kouta Kazuraba as a great threat to their plans.
- While he managed to create three new Sengoku Driver prototypes, along with three new Lockseeds, as suggested by Melkor, Ryoma was utterly pissed off after one of the new Sengoku Driver prototypes and his new Lockseeds were stolen by Iron Man. Which in turn, Ryoma swears he will get his revenge against him.
- Since he had two more prototypes left, Ryoma change his plans by modifying one of the prototype driver with the Genesis Core attached to it while creating new Lockseeds based on Gaim Yami's data, as well as creating another Yomotsuheguri Lockseed since he found an ideal candidate for this purpose. He also gave some newly-made drivers and Lockseeds to Enoshima, Sugou, and the Reagan siblings as well, as a means to collect data against their respective adversaries in their battles, not to mention that they want revenge on their foes which is the reason why he gave the drivers to them in order to fulfill their personal goals.
- Was briefly fascinated and amused by the arrival of the hero Kamen Riders from the world of Build, interested at the idea of them using Evolt's own gathered energy to create a whole new world, at times holding this fact over the alien's head. All of Ryoma's amusement went of the window when he learned that Sento Kiryu has been acknowledged as having the highest IQ of all of the Heisei Kamen Riders, something that really gnaws at the high self-esteem of someone like Ryoma. Their most recent conversation didn't help:
- "My brilliance... and research... are the only things of value. They are the truth of this world!"