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Bloody Murder

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Just had to eat at Denny's, didn't you?

"It's got a wonderful defense mechanism. You don't dare kill it."
Parker, Alien

Generally, bleeding isn't a good thing, what with the whole "bleeding to death" bit and there usually being an angry person nearby wanting to make you bleed some more; however, some have the ability to turn their lifeblood into the deathblood of their adversaries.

Whether it's a vampire, "Blood Mage," aliens, Mutant, demon or more exotic fare, this character can kill with Bloody Murder, the ability to use blood as an offensive weapon. Possible weapon mechanisms include:

These characters might have Black Blood or Alien Blood as side effects/causes for their powers, but will usually have at least Hollywood Healing or a Healing Factor to deal with multiple open wounds. Often this is justified by saying that controlling the blood allows for faster healing. If they can actually manipulate blood (including voluntarily shooting blood from their body) it overlaps with Master of Your Domain.

If the blood is drawn from the user wounding themself somehow then it's a Self-Harm–Induced Superpower.

Not to be confused with Rustproof Blood or Melty Blood. Or with a murder that is simply unrealistically bloody.


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    Anime & Manga 
  • In Akame ga Kill!, a fatally-wounded Liver manipulates the water in his body to fire it at Bulat as a Taking You with Me attack. It barely seems to affect Bulat... then Liver reveals the Super Serum he'd taken earlier also contained a deadly incurable poison.
  • Ginshu, the Miko from Amatsuki, has blood that is poisonous to demons. This prevents them from eating her/him (though it doesn't stop them trying).
  • In Basilisk, Akeginu of the Iga Tsubagakure group not only is extremely seductive as well as deadly with her trusty tanto dagger, but she can also control her own blood, secreting it out of her pores to blind or tag her opponents or create a sort-of mist as she mixes it with the air in her surroundings.
  • In Black Cat, Charden has the power to manipulate blood, mostly his own.
  • Black Clover:
    • By injecting her blood on a target, the Witch Queen can use her Blood Magic to take control of them. Alternatively, she's powerful enough that she can also use her blood to heal wounds or exorcise ancient curses that modern magic is powerless against. She can even bottle up her magic in order to allow a third party to use it. Finally, she can form a scythe made of blood to attack with.
    • Vanica uses her Blood Magic to attack by solidifying it, forming wings and a giant claw from which she can unleash bladed beams of blood. Her magic can be weakened if she's surrounded by a body of water, which causes her blood to dissolve, though Vanica is so strong that she can power through most water attacks regardless.
  • Bleach:
    • Mayuri tends to fill Nemu's body full of poisons and various experimental drugs. In at least once case, when an enemy tried to use her body to regenerate himself, the poison was transferred to him with dire results. Another enemy consumed Nemu's remains after reducing her to Ludicrous Gibs, and contracted an equally ludicrous form of cancer that was only kept in check by Nemu's brain, which said enemy could not eat after Mayuri specifically prevented it from doing so.
    • Giselle Gewelle has the power to take control of anyone who touches her blood. Her main tactic is to goad people into slashing her so her blood splatters on them. She has a Healing Factor, so she doesn't have to worry about dying.
  • Blood+:
    • Chevalier can be killed only if exposed to the blood of the other Chiropteran Queen. Likewise, a Queen can only be killed by her sister's blood. It stops working after they become pregnant. While anything that exposes a Chiropteran to the opposing Queen's blood will work, such as Saya cutting herself with an ordinary knife and then cutting a Chiropteran with it, her signature weapon is a customized katana with a small sharpened section on the back of the blade and groves to spread her blood along its full length.
    • Saya also enters a state of increased strength, speed, and senses if she draw her own blood.
  • Blood Blockade Battlefront: All of the main members of Libra (barring Leo and Chain) are capable of weaponizing their blood in a variety of ways.
  • Tsukimiya from Bloody Cross can weaponize her blood, for example her "Blood Tepes/Blood Skewer" attack can make her spilled blood turn into spears that shoot up and impale her opponent.
  • In Brave10, aside of Lotus-Eater Machine, Kuchiba's other skill is to weaponize blood.
  • Bungou Stray Dogs antagonist Nathaniel Hawthorne can turn his blood into scripture quotes that can be used in a variety of ways. Small passages get sharp edges and are weaponized; longer excerpts can be condensed to use as a shield.
  • Power of Chainsaw Man is a Fiend, or a devil inhabiting a human corpse. As a blood devil, she uses her host body's blood to create weapons.
  • Code:Breaker: The five Saint Fighters Aoba/Code:Revenger's goon squad all have this ability. This might be a sign that they're sisters, since the only other pair of people with the same power is a sister who shared it with her brother.
  • In Darker than Black, the contractor Wei Zhi Jun is shown to have teleporting blood, which he uses offensively by cutting himself and splattering it on his opponents before he it activates it by snapping his fingers to take chunks of people and objects with it. Superpowers in this setting are Power at a Price, requiring acts called "remunerations" to use them, but Wei's remuneration is cutting himself, and the cut he makes to draw blood for this power explicitly counts, so he basically doesn't have a remuneration.
  • Deadman Wonderland features a group of protagonists called Deadmen who possess the unique ability to kinetically control their own blood, which they primarily use to shape it into weapons—whips, bullets, you name it. The lead is the one with the bullets, which is annoying since the thing about bullets is they don't 're-use' very well, and Crow with his scythe can just keep slicing while Ganta has less and less blood in his body to work with. It also doesn't help that Ganta is much smaller than the adult characters and thus has less blood to begin with.
  • Low-level Akuma in D.Gray-Man fire bullets made of their blood. It causes Body Horror and very quick death. Arystar Krory has blood that's immune to it. He can also infect Akuma with his own blood, which causes much the same effect as their blood has on humans. He can also make a marionette out of his own blood.
  • Digimon Adventure:
    • Vamdemon/Myotismon possibly has this, in the form of his Bloody Stream/Crimson Lightning attack, where he conjures a scarlet-red energy whip to attack.
    • His evolved form, BelialVamdemon, also has his Melting Blood attack, which dissolves enemies with blood from his shoulder cannons.
  • Though it's not actually used as a weapon, Hyatt in Excel♡Saga has poisonous blood. Ingesting it will cause cramps and nausea, and it releases deadly gasses when evaporating. She also has a nasty habit of vomiting it all over the place.
  • Fairy Tail: when Gray fights Ultear, she uses her time magic to melt all of his ice. Since Ultear's power only works on inanimate objects, he attacks her with some of his frozen blood.
  • Flame of Recca:
    • At one point, Tokiya Mikagami begins to run out of juice for Ensui, his water-based weapon, and uses his own blood to power it.
    • Towards the end of the manga, Hiruko of the Shishiten demonstrates the ability to control blood directly, absorbing it from his enemies and using it to heal himself and create crystalline weapons.
  • In Fullmetal Alchemist: Brotherhood, Isaac McDougal the Freezing Alchemist can freeze his blood and attack with it.
  • Get Backers:
    • Akabane once used the diamond dust he'd inhaled to create another one of his infamous scalpels. Anything that mixes with his bloodstream can be manipulated thusly. His Bloody Sword seems to actually be created from his blood.
    • Emishi also has flammable blood, and once used it to try to burn Shido to death. It's a desperate, last-chance attack, though; he usually sticks to his whip
  • Alucard of Hellsing can make his blood, and indeed the spilled blood of others, do anything he wants. Anything. This includes absorbing the blood of his victims to claim their soul, all the way up to releasing literal tides of blood to spawn thousands-strong armies of said absorbed souls.
  • Otenkun of Hoshin Engi and his blood that melts metal and can turn into noxious, acidic gas.
  • Inuyasha:
    • Inuyasha can use his own blood as an Emergency Weapon, throwing crescent-shaped, sharp-edged splatters that are similar in effect to Razor Wind. Though it's rarely used after he learns a Sword Beam attack.
    • In the sequel, Inuyasha's daughter Moroha is shown to be capable of using the same technique.
  • JoJo's Bizarre Adventure:
  • Jujutsu Kaisen: The Kamo Clan's hereditary Cursed Technique allows them to manipulate their own blood in order to attack their target. They can control practically all aspects of their blood, up to and including temperature, solidity and pulse rate; this allows them to increase their physical capabilities in melee combat. Higher level techniques even allow the user to ensnare their target, or shoot their blood in the form of rotating disks, hardened bullets or a highly-pressurized beam capable of slicing through concrete. Noritoshi Kamo from Kyoto Jujutsu High usually has to carry spare bags of blood when his own begins to run low. Choso, the eldest of the Death Paintings, gets around this by generating more blood from his own cursed energy; being a human-cursed spirit hybrid means he has a lot more cursed energy to spare.
  • Yuugami from Kekkaishi can turn his blood into weapons, as well as large, flying familiar-type creatures. Subverted in that he doesn't actually have any more blood than the average person and has to save it up for months before he has enough to do anything elaborate with it. He's also been shown reabsorbing blood stored for emergencies, so apparently he also has special red blood cells that can live for longer than the standard 3 or 4 weeks outside of the body.
  • In The Legend of Zelda: A Link to the Past (2005), Ganon's blood itself is acidic, as shown when Link cuts him with the Master Sword and the blood dissolves Agahnim's corpse.
  • Vlad King aka Sekjiro Kan in My Hero Academia has the quirk "blood control ". He can manipulate his own blood after ejecting it from his glove. He can reabsorb the blood after the fight.
  • Nagi from the My-HiME manga uses his own blood to summon Orphans.
  • Naruto:
  • Vampires in Nightwalker can bite themselves and control their blood to form bladed weapons.
  • Used in One Piece during the battle against Crocodile, who can turn into sand. His power doesn't work when he gets wet, so Luffy used the only liquid he had handy; blood from the wounds he was receiving.
  • In the Saint Seiya: The Lost Canvas, Pisces Albafica manipulates his poisonous blood to attack his enemies. Since he has worked with poisons for so long that his mere touch is deadly, it also doubles as a method of injection.
  • Samurai Deeper Kyo: Shinrei is able to form a sword out of his own blood.
  • Boris Tepes Dracula from Shaman King uses blood as his spirit medium.
  • Soul Eater: The Black Blood can solidify in the body beneath attacks, protecting the body against blows, as seen used by both Crona and Maka when she gets under its influence. Crona's black blood goes further, being the shapeshifting weapon partner, Ragnarok, who can still cut you up even after leaving the body in all directions. Black Clown is made of black blood as well and can merge with Crona for an additional power boost.
  • In Speed Grapher, Anti-Villain Suitengu Chouji's superpower allows him to control his blood in a variety of ways. He can create wings of blood that somehow support his weight, levitating drops of blood to throw at people, full-sized human puppets made of blood and make his blood sharp enough to cut people. On the other hand, he tries to not use it unless he can't win otherwise, since his body's need to rapidly heal itself over where the blood comes out brings his cells closer to cell death, thereby shortening his lifespan.
  • In the second Tengen Toppa Gurren Lagann movie, Simon finishes off the Anti-Spiral by forming his blood into a drill.
  • In the Tenjho Tenge manga, among the abilities Souichiro steals thanks to his power is a sort of 'water bullet', however Souichiro uses his own blood as a medium, and usually only after being wounded as opposed to going out of his way to bleed.
  • Senri Shiki of Vampire Knight can form a long, telekinetically-controlled whip of blood able to slice through most living tissue.
  • The Duel Monster Destiny Hero Bloo-D (how appropriate) in Yu-Gi-Oh! GX can rain down a swath of spears made out of blood spawned from his wings.
  • YuYu Hakusho:
    • Kiyoshi Mitarai, also known as Sea Man, had the ability to create water horrors by mixing some of his blood in it.
    • In addition, ninja demon Gama is able to make enchanted ink from his blood, which can paralyze enemies and lock their energy inside of their body, as well as, in outside material, make himself invisible. Kurama, after fighting him despite being partially paralyzed by his ink, makes the mistake of grievously injuring him, which, while causing him to die, weakens Kurama to an extreme degree due to the massive amount of blood that Gama spilled.

    Comic Books 
  • The Engineer in The Authority has nanomachines in her blood which she uses to create weapons.
  • Batman: The Joker has highly toxic blood. Depending on the Writer, it's either from his tumble into a vat of chemicals that resulted in his appearance, or from sampling his own toxins.
  • Captain Atom, when he's in Captain Atom form, bleeds energy when he's cut, as do Major Force and the Silver Shield (who share his origin). When the Silver Shield was first cut, the radiation release killed Damon Long and poisoned Heinrich Megala.
  • Cosmic Boy has manipulated the blood of those he was extremely upset with, the first time he did this he was initially planning on horrifically killing the terrorists in question but decided to keep to his no killing rule at the last second. It is extremely painful and leaves them begging for an end. He's also manipulated the iron in his own blood when low on options.
  • Crimson Plague can use her blood as a very deadly weapon indeed; it will eat its way through just about anything and just a few drops are enough to turn her opponents into piles of fleshy goo. When she gets her period her blood even spawns a virus that can kill a whole planet within a day. Add this to the fact that she's batshit insane and you have yourself one of the nastiest comic book characters around.
  • The Flash: After experimenting on his blood with the blood of metapowered criminals, the hemophilic Ramsay Rosso developed the ability to transform his flesh into a blood-like physiology and became the supervillain Bloodwork.
  • Green Lantern: The Red Lanterns have this as their main gimmick. To go a little more in depth, should you feel great rage and receive a Red Ring, you vomit out all your blood, which is then replaced by red light constructs of your bloodstream. Which means that any Red Lantern who overcomes the Unstoppable Rage the ring induces (with one exception) dies immediately.
  • John Constantine of Hellblazer has demon blood as a result of a demon healing him. He specifically warns a child not to bite him at one point, because "you really don't want my blood in your mouth". When the King of the Vampires tries to drain Constantine, his jaw dissolves.
  • DC's Lobo has the ability to spawn a full-sized clone from a single drop of blood, though it was genetically removed by Vril Dox, his former employer in L.E.G.I.O.N. (DC Comics). Different writers have seen fit to bring it back at their discretion.
  • Runaways:
    • Nico Minoru has a staff of power that only emerges if she is actively bleeding. Normally, this involves cutting herself (which is extra hilarious due to how goth she dresses), but she can call it forth at any time when she's on her period.
    • Karolina, an alien from a race that absorbs energy from stars, accidentally kills a vampire by offering her solar-powered blood up as a Heroic Sacrifice.
  • Spider-Man:
    • Villain Carnage was created when an alien symbiote merged with the bloodstream of serial killer Cletus Cassidy. Mass-murder ensues.
    • Spider-Man's blood is radioactive, a fact that has caused the defeat of more than one vampire that has attacked him.
  • Superman was once bitten by Dracula, but his solar-powered blood made the vampire lord explode.
  • The titular villain of Sword of Dracula wields telekinetic control over all the blood he has ever drained. His mastery is such that he assembles weapons, horses, minions and full-size castles with the stuff.
  • Vampirella: Villain Hemorrhage can control any blood. (Even if still inside its proper owner.)
  • The X-Men comics had a character who could weaponize other people's blood by making them bleed then igniting the oxygen in the exposed blood. His name was Adam-X, The X-Treme. Oh, Nineties. (It was hinted that he was the rumored third Summers brother.note  If only...)

    Fan Works 
  • In CRISIS: Equestria, Red Velvet has the power to form her blood into constructs like blades and tentacles. She can make her constructs very huge even though her body couldn't possibly hold that much blood, implying her magic increases it.
  • In Desperation Attracts Vultures, Naruto can use his newfound control over water to control someone's blood if he puts enough of his chakra into their body. He uses it against Neji to break his fingers by bending them backwards.
  • In Fallout: Equestria an alicorn crystallizes her own blood into daggers to fight Littlepip. Pip later repurposes the technique (or at least its principles) to create blood-bandages for Xenith.
  • In Fate/Parallel Fantasia, False Saber's Noble Phantasm allows him to generate swords from his blood. They're fairly weak as far as Noble Phantasms go; but because Servants have a powerful Healing Factor, he can produce them in great numbers without risking killing himself.
  • My Bloody Academia: Ryuko Matoi's Quirk allows her to control and manipulate her own blood in ways only limited by her imagination. She can form bladed weapons from it durable enough to slice through and destroy solid steel, as well as solidify it inside her body to amplify her own durability.
  • In Pages Of Harmony, the "Boiling Blood" variant occurs during a procedure that simulates conditions in space used by Twilight Sparkle to kill Fluttershy to extract Kindness.
  • In Make a Wish, Harry's incredibly poisonous blood (it contains Basilisk venom) protects him several times. The first, when he is attacked by werewolf Fenrir Greyback, poisoning Fenrir while Harry completes the work with a silver knife. The second, when Lord Dracula gives him blood to turn him into a vampire (the only way he won't become a werewolf) but instead stabilizes things and turns Harry into some sort of hybrid. The third, when he gets bitten by several Australian poisonous spiders, who bite it when Harry's blood enters their mouths.
  • The Mountain and the Wolf: Some of the Crow Brothers have blood made of insects, which attack their enemies when wounded.
  • Necrophobia: Marion Gremory aka Bloody Mary is this, being able to shape her blood into thick, prehensile tentacles due to her being a Blood God Slayer.
  • In Pony POV Series, since Princess Cadence is the goddess of Harmony, her blood will petrify a Draconequus (beings of chaos) on contact. As Queen Chrysalis is sort of a spiritual clone of Cadence, she has this ability as well.
  • In Power Rangers: Oceania, Hine Nui has black blood that is diseased. Watching a mosquito take a snack and then die inspires her to revive it and send it after the Rangers, spreading her blood and its malaria-like effects.
  • In A Protector's Pride, Urahara's bankai allows him to summon and control the blood of everyone he's ever killed. This is implied to be a lot of people.
  • In Voyages of the Wild Sea Horse, the unique power that separates the Model Type: Vampire mythic zoan from the other fruits of the Bat-Bat Fruit family is that the consumer is able to mentally shape and manipulate blood, either their own or that which is just laying around — they can't control the blood presently inside of a person's veins. At least, not prior to Awakening, maybe. As its bearer, Nabiki Tendo, is literally learning about her powers as she goes along, we haven't seen many uses of it yet outside of creating weapons of solidified blood and launching solid blood projectiles, though presumably the "prehensile blood" option is also under its aegis.
  • In Winter War, once the Barragan Fragment assumes a humanoid form again, its "age things to dust" power is reflected in its blood, which becomes the "corrosive blood" variant of this trope. The characters find this out the hard way, with one of them losing a hand due to blood splatter when she managed to cut it.
  • In With Strings Attached, the Brothers of Doom have a death touch, but they also have blood that will instantly kill anyone it touches, so when they expect invaders, they bleed into cups so they can throw it at people.

    Films — Animation 

    Films — Live-Action 
  • Alien:
    • In the film series, the aliens have highly corrosive blood, making it very dangerous to wound them, especially while in space, because it is very likely to eat straight through the hull. The acid blood was created for the first film as an answer to the problem, "Why don't they just shoot it?"
    • In later films, the aliens prove to find active uses for their acid blood. In Alien: Resurrection, two aliens kill a third to escape their holding cell. Ripley 8, who is a part-alien clone, is also shown to have acidic blood, although much less potent.
    • In AVP: Alien vs. Predator, an alien that gets its tail stinger chopped off proceeds to whip its wounded tail around and spray acid blood everywhere.
    • In the spinoff movie Prometheus, the snake-like creatures bleed the same kind of acid-blood.
  • The real danger from the monster in the classic kaiju film The Beast from 20,000 Fathoms is the prehistoric diseases in his blood that humans have no immunity to. The challenge is to kill him in a way that won't produce torrents of blood (they use a highly irradiated sniper bullet).
  • In the 1981 Clash of the Titans, Medusa's blood melts Perseus's shield — and not any ordinary shield, but one given to him by the gods. And as if that wasn't enough, later on drops of her blood turn into giant scorpions (possibly due to something Calibos did, but it's not entirely clear).
  • In the movie Daybreakers, this becomes a major plot point near the end. In particular the cure to vampirism is spread by drinking blood from a cured vampire.
  • Hedorah from Godzilla vs. Hedorah has blood acidic enough to dissolve Godzilla's hand to the bone.
  • The Tales from the Crypt movie Demon Knight actually features two types of blood-based attacks. In one scene, the Collector, a powerful demon, cuts his hand and spills his green blood on the ground to form a small army of lesser demons, which rise from the blood itself. But blood was also his only weakness — specifically, the blood contained in the Key (the film's MacGuffin). That's because the Key contained traces of the blood of Jesus Christ, mixed in with that of countless Guardians of the Key. The blood was not only deadly on contact to the Collector, but the protagonists could spill the blood in doors and windows to make it impossible for demons to enter; they would explode if they tried.
  • In the Dungeons & Dragons (2000) movie, one drop of red dragon blood turns a lake into a Bunsen burner.
  • In Mortal Kombat (2021), Subzero slashes Scorpion's back, freezes the blood splurt, and uses the frozen blood to stab Scorpion in the back.
  • Pacific Rim: Kaiju blood is damn toxic, even after evaporating, and considering the sheer amount of blood a Kaiju has you can imagine the sort of cleanup hell that has to happen once one falls.
  • Blood comes alive with a taste for murder in Species II apparently.
  • Played with in Saw: The two unfortunate gentlemen are told that the dead body lying in the middle of the room has a high enough concentration of toxins in its blood to be deadly. In fact the body isn't dead at all and belongs to the Jigsaw Killer, their captor.
  • In Subspecies, the vampire Radu's blood can spawn the titular creatures when spilled.
  • The Thing (1982): The shapeshifting monster is capable of regenerating each severed but unburned piece of itself into a fully autonomous being. Even blood will crawl away from danger and can (if allowed) potentially respawn into a full-grown monster. The characters use it as a foolproof method for telling them apart from the humans they're otherwise mimicking perfectly. Systematic testing of the entire base personnel and electrocution of the failures with an overclocked cattle-prod follows, forcing the remaining monsters to declare themselves on the spot.
  • Tokyo Gore Police: The "Engineers" can make weapons emerge from any wound they suffer, and there's a drug that can let a person spray blood with enough pressure to use it as a means of propulsion.
  • Vampire Girl vs. Frankenstein Girl: The eponymous vampire girl can turn her blood into blades, spikes, and even serrated wheels.
  • In X2: X-Men United, Mystique smuggles metal into the government's plastic prison (where Magneto is being held) by injecting a security guard with some sort of iron-rich solution.

  • Lone Wolf:
    • In The Kingdom of Terror, if you press the attack against the Dakomyd, its watery blood splashing on Lone Wolf's arm burn through his tunic and sear the flesh, as well as corroding the weapon.
    • In The Deathlord of Ixia, a Lencian soldier strikes an undead Cabalah with a sword, which only results in a splash of corrosive blood corroding the weapon and reducing his hand to a stump.

  • Mirai from Beyond the Boundary has "cursed blood"; as well as being highly corrosive, she can form it into a sword with which to attack. However, due to these powers, she is treated as "cursed" and ostracized by her fellow youmu hunters; there's also the risk of her losing too much blood and passing out.
  • Granny Weatherwax from Carpe Jugulum. There's really not more to it than that: she uses blood as a weapon, and the weapon is her. Well, the blood is a delivery system...
  • In The Chronicles of Amber, Amberites can make Pattern Ghosts real with their blood. The blood of any descendant of Dworkin can also damage the Primal Pattern, which hold Amber and the Multiverse it spawns together. Bad Things Happen when an Amberite bleeds on that Pattern. The Chaosites, on the other hand, have blood that bursts into flame on contact with air. For Merlin, a Chaosite/Amberite hybrid, whether he bleeds fire or blood depends on whether the shadow reality he is in is nearer to Amber of Chaos.
  • Bora Horza Gobuchul, the changeling protagonist of the Culture novel Consider Phlebas, can makes his own blood and saliva highly poisonous, so guess what happened when the leader of a cannibal sect tried to eat him
  • There was a Weaponized Blood of Mass Destruction version in Charles Sheffield's last novel, Dark as Day. A character carries nanomachines in his bloodstream that, when dropped into a gas giant, will shift high-pressure hydrogen into a denser configuration, collapsing the planet and releasing a big enough burst of energy to destroy civilization. The character also has mental programming to seek out an opportunity to dive into a gas giant...
  • In Cursed World, the Ferromancer who serves as the mysterious atagonist f the first book murders a cop by manipulating the iron molecules in the cop's blood to form a crystal that stabs him to death from the inside.
  • Witch's blood is deadly poison in the Ever World books, though I don't believe it ever gets used against people. They just hold a very important plant hostage.
  • Fate/Requiem: Erice Utsumi can turn her blood into bullets and weapons like axes. Her blood is also toxic to Servants and when she kills them with it, the blood absorbs and dissolves their spirits.
  • Forest Kingdom: In the Hawk & Fisher spinoff series' book 2 (Winner Takes All), one of the assassination attempts on Reform candidate James Adamant involves a monster made of blood.
  • Marshal Atkins, from John C. Wright's Golden Age, has the Blood Horrors type: intelligent nanites that can poison or corrode, as ordered.
  • In The Golgotha Series, the villain Phillips is nearly invincible, but Mutt is able to harm him using a knife coated in Mutt's own blood. This due to Mutt's blood carrying the spiritual power of his father, the god Coyote.
  • Grimoires Sigil: Harper's specialty is in blood magic, which she uses to easily dispatch the Kesterline mages holding her hostage due to Sebastian choosing to leave her alone, but can also be used to heal by using it to clot wounds.
  • Legacy of the Dragokin: Fury can use the Prehensile variety; she uses her blood as whips and spears.
  • In the New Series Adventures novel Forever Autumn, the Doctor temporarily disrupts the antagonists' biological ship by smearing a drop of his blood over one of its surfaces. Later on he threatens to overwhelm the ship completely by slitting his wrists all over the floor.
  • Old Man's War:
    • Enhanced human soldiers have their natural blood replaced with SmartBlood, composed of nanomachines. While not explicitly intended as a weapon, in The Ghost Brigades, Jared Dirac discovers that it is possible to remotely instruct the nanobots to explosively combust once outside the body. He uses this technique to momentarily stun an attacking alien after his tongue is cut during combat. Later on, it is revealed that the SmartBlood can also be ordered to ignite while still in the body, which he does when the villain is about to take over his body.
    • In The Human Division, another CDF soldier is able to use this tactic while being restrained and interrogated.
  • The oldest of Anne Rice's vampires have the Boiling Blood variety, called the Killing Gift. This is essentially how Akasha kills most of the world's vampire population in Queen of the Damned; she ignited their highly flammable changed blood and set them on fire from the inside out. The power later got retconned into two separate abilities, with the Killing Gift not really being detailed but assumed to make ruptures in the victim's cardiovascular system.
  • In Renegades, Ruby, known better as the superhero Red Assassin, can crystallize her blood into weapons, which she uses to fight.
  • Naofumi has a spell in The Rising of the Shield Hero granted to him by the Rage Shield, "Blood Sacrifice". By expelling enough of his own blood, it summons a terrible maw to appear and bite down on his victim before dragging their bloodied corpse into a pool of bubbling blood.
  • Saintess Summons Skeletons: Astelia's version of the vampiric [Blood Curse] racial skill causes her spilled blood to burst into flames that burn more intensely than normal fire. Together with her abnormally large health pool and [Greater regeneration] passive skill, Astelia has the option of cutting herself and using space magic to launch the blazing blood at her enemies, although we've only ever seen her employ this strategy against monsters capable of reforming even after being torn to pieces.
  • The scabmettlers of China Miéville's The Scar are a race whose blood clots extremely quickly. Before going into battle, they cut themselves in certain ritualistic pattern, and the results blood flows harden into armor and weapons.
Blessed with Suck to some extent, since they need to medicate themselves constantly or risk spontaneous clots that will turn them into statues. It does, however, come in handy when Armada needs to send a delegation to the island of the Mosquito People.
  • In Star Wars Legends, the voxyn, Jedi-hunting beasties created by the Yuuzhan Vong, have blood that becomes a deadly neurotoxin in most kinds of air... so even if you kill the thing without being bitten/clawed/spat acid on/hit with tail spines/eardrums burst by screech... you might still be screwed.
  • Sanguine from Super Minion has control over blood. He can bleed himself for a weapon to attack with, and can also bleed an enemy dry from the slightest wound.
  • In Sword Art Online, during Alicization Uniting, when Eugeo's Blue Rose Sword snaps in half, he uses Incarnation to reforge the blade using how own blood so that Kirito can use it. The new sword is red in color and is christened the Red Rose Sword.
  • In The Sword of Truth, there is a scene where Richard kills some monster, and a drop of its blood on his arm requires later treatment. As it dies, the monster transforms into a mass of snakes. Richard kills a few snakes, and they transform into bugs, whose bites must also be treated.
  • In the Takeshi Kovacs series, where people are capable of downloading their consciousness into new bodies, one of the custom modifications available is blood loaded with deterrent-toxins. In Broken Angels, Luc Deprez recounts how he successfully assassinated a target, only to die afterwards when the target's blood turned out to be a slow-acting poison.
  • In the Barbara Hambly novel Those Who Hunt the Night, a vampire character kills a vampire by injecting himself with a lethal dose of silver nitrate (silver being fatal to vampires in this setting) and allowing the vampire to drain him before he succumbed to the toxic effects of the silver nitrate.
  • Tolkien's Legendarium: J. R. R. Tolkien's dragons have poisonous blood, corrosive and/or blazing hot; if you have the guts to sword a dragon's belly, chances are that you will be killed by it, or at least disfiguringly burned/scalded.
  • In the Tortall Universe, spidrens have acidic black blood, as Daine finds in The Immortals. Downplayed in this case, though. Getting splashed with spidren blood burns, but the injury it causes is pretty minor.
  • One guy in Trinity Blood has blood that instantly combusts when it comes it contact with air. The main character can also make a scythe out of his while in his Super Mode.
  • Warhammer 40,000 Expanded Universe:
    • Duke Venalitor from the Grey Knights novel Hammer of Daemons has the ability to make any shed blood into prehensile tendrils.
    • In the Thousand Sons novel Ahriman: Exile, Ahriman kills a minor Chaos Lord by magically destroying the chemical bonds which hold his blood cells together. The results aren't pretty.
  • Myrddraal blood in The Wheel of Time series will corrode the metal if not cleaned. Other types of shadowspawn have the same effect, only faster so their blood needs to be cleaned immediately.
  • Worm: Hemorraghia's power lets her form weapons and shields out of her own blood. Injuring her is likely to backfire.

    Live-Action TV 
  • When Angelus gets loose in Angel, Wes and Faith take him out by using Faith's blood against him. They know Angelus won't be able to resist trying to turn a Slayer, so they inject Faith with a dangerous hallucinogen just before the fight, then let him win. It's a big risk, but it works — Angelus is unconscious long enough for Willow to restore his soul. The downside is that Faith then has injuries from her fights with Beast and Angelus, a drug overdose, and blood loss that Angelus drank.
  • Werewolf blood is toxic to vampires in Being Human (UK). George exploits this in one episode by biting his own wrist and forcefeeding his blood to a vampire, killing it.
  • In Lessons for a Perfect Detective Story one episode was all about trying to discover what the weapon was, as there was absolutely clue as to what it could be. In the end, it was revealed that the murderer, who had access to blood bags at the hospital he worked at, froze some blood of the same blood type and stabbed the victim with it, which would eventually melt and get lost amongst the victim's blood. This was subverted when it turned out the victim had fallen off the roof and stabbed himself in the chest with his own shin bone.
  • Dark Angel's second season featured a plot arc based on Max's DNA having been altered to be poisonous to Logan on contact. Not blood, exactly, but any secretions would have the same effect.
  • The Flash (2014): Bloodwork's main power is controlling blood, which he is able to shoot out.
  • In the Haven episode "Bad Blood", when Mike Gallagher's blood is shed, it gains a life of its own. It starts out as a few drops, but it can drain a person's blood completely through skin contact and add the stolen blood to its own mass. It can travel along the ground and even through water or sewage without getting diluted or contaminated and does not leave any residue behind. Mike had no control over it.
  • In Oz, Simon Adebisi steals blood from the AIDS ward, and uses it to infect Antonio Nappa via a hypodermic needle stick.
  • Ultraman Taiga introduces a new monster, Segmeger, a poison-based kaiju whose venom extends to it's purple blood. While fighting Ultraman Titas the monster uses it's blood as a weapon to momentarily blind the Ultra.
  • When the alien hybrids from The X-Files are injured, their green Alien Blood bubbles and releases some kind of toxic gas or something. It is also both corrosive and lethally infectious. Putting the victim on ice can slow the effects, and a course of antiviral drugs can remove the infection.
  • The Boys (2019): There is a unknown character with the ability to blow off limbs and heads known as "the head popper".
  • Gen V (2023): Main character Marie Moreau has the ability to manipulate and control her own blood as well as others. Although Marie has to harm herself to use her own as a weapon, she can use any in close proximity to her. She can use it as a weapon, and to stop someone from bleeding to death.

  • One of the titular "Warriors of Time" in the music video for the song by Black Tide seems to have this power. He even creates a tidal wave of blood that floods into the enemy giant robot, making it explode.
  • The Dethklok song "Bloodrocuted" tells the story of an electrician being chased through the woods by bounty hunters because he happens to be a wanted criminal out there who looks just like him. He leads them to an electrical substation, where he manages to kill the bounty hunters by cutting himself and electrifying a puddle of his own blood for them to step in. Then he dies because he can't stop his cuts from bleeding.

    Myths & Religion 
  • In Classical Mythology Nessus was a centaur killed by Hercules for trying to rape his wife, but Nessus somehow convinced Hercules's wife that his blood was a love potion, so one day she smeared it on his shirt. Hercules was poisoned by the shirt and in agony from the non-fatal corrosion, immolated himself to end the pain. However, the centaur's blood itself wasn't the poison — the arrow used to kill Nessus was one of those that Hercules had poisoned with the blood of the Hydra of Lerna, one of the monsters that he slew during his Twelve Labors, and the hydra's blood was mixed with that of Nessus.
  • Older Than Dirt: In Enûma Eliš, the Mesopotamian creation myth (ca. 1600 BCE, maybe), the evil mother goddess Tiamat gives birth to dragons that, among other awesome features, have "venom for blood". Bad-ass.
  • The Asura Raktavija could regenerate from a single drop of blood, therefore requiring Kali to drink all of his blood before he could be killed once and for all. In other versions, she strangled it.
  • Another myth included a monster who would spawn mooks from his blood whenever wounded. Unable to beat him, Durga transformed into Kali, who promptly solved the problem by eating him whole.
  • The dragon Fafnir of Norse Mythology had corrosive blood in some versions of the story, and this required Sigurd to dig a pit to catch the blood in order to avoid being killed by it. (In other versions, the blood was not corrosive and indeed conferred invulnerability on Sigurd when he bathed in it.) Some have a bit of both; though bathing in the blood made him invulnerable it felt like bathing in Hollywood Acid.
  • The European basilisk was a creature so vile, in addition to its venomous bite and habit of causing people to drop dead just by looking at it, also had blood that was so toxic, if a man stabbed it on horseback, the poison would radiate through his weapon, killing not only the man but his horse.
  • In some versions of the story, the blood falling from Medusa's severed head dripped down into the Sahara desert over which Perseus flew, transforming into venomous snakes. In other versions, Pegasus sprang from it, and in still more, her blood petrified Atlas and turned seaweed into red coral. Really, there wasn't a lot it didn't do.

  • Dawn of a New Age: Oldport Blues:
    • Part of Daigo's vampiric powerset is the ability to control his own blood, which he can shape into weapons once it leaves his body. On top of that, his blood can turn other people into monsters if they ingest it.
    • Devin's blood is acidic, meaning he can use his acid manipulation power to control it and cause corrosive harm. When he first displays his power, he shapes his blood into a dagger to attack Hyeon with.
  • Survival of the Fittest: Evolution's Taryn Gregory has her blood crystallize into sharp shards under exposure to oxygen, which can be broken off from the wound and used as a weapon.
  • In We Are All Pokémon Trainers, Constantin, a villainous psychic, can use telekinesis to form his exposed blood into a whip as a desperation weapon.

    Tabletop Games 
  • In addition to being Cast from Hit Points, the Whateley clan's Blood Magic in Deadlands has a number of spells that bolster the caster's abilities. For instance, in exchange for letting dark powers devour some of the Blood Mage's tasty, tasty essence, the spellslinger might get Instant Armor. In exchange for actually doing their bodies overt physical harm, they might recover some of the game's version of Mana. (In case you're not getting the idea, that last ability is called "Faustian Deal")
  • Dungeons & Dragons:
    • Forgotten Realms:
      • The spell "Blood Lightning" remains indefinitely as a "curse"; after bloodletting begins, the subject can choose whether to receive a weak healing or sweep everything else around with red lightnings discharged from wounds.
      • Also, Chosen of Mystra tend to bleed "Silver Fire", a form of raw magic. In the fall of Myth Drannor a colonel of Army of Darkness caught overconfident Khelben (then "Nameless Chosen") and tried to tear him in half — he almost succeeded, but ended up completely obliterating himself and everyone nearby... while Khelben survived (barely).
    • In 3e and 3.5e, the Blood Magus prestige class is entirely built around blood-based abilities, including stepping into one creature with blood and out another, and granting temporary sentience to an enemy's blood, which then proceeds to attempt escape. Painfully.
    • D&D 4e features a defensive use in its magic Bloodcut Armor, which allows a sufficiently injured character to ignore a certain amount of further damage when it is active.
    • According to the Fiendish Codex: Tyrants of the Nine Hells, every drop of Asmodeus' blood that falls to the ground turns into a pit fiend.
    • Spells:
      • 3.5e Spell Compendium includes a spell that causes the victim's veins to escape from it. Appropriately it requires a save against instant death, and even if that succeeds the person takes massive damage and then must untangle their own entrails in order to escape.
      • Related to this is the 3.5 Assassin spell heart ripper, which, if the target fails a save vs death, blasts the target's heart out of their back.
      • The spell fire in the blood from Heroes of Horror makes the spilled blood of the subject turns into an acid spray that unrelentingly hit the one that spilled it in melee.
      • The draconic spell burning blood (from Draconomicon) is similar, causing a spray of blood around the caster whenever hit by weapons, which causes energy damage of the same type as its Breath Weapon.
    • In 5e, there's a variant rule for demons that can let them have venomous insects for blood. The first time such a demon drops below 1/2 hitpoints in a battle, a swarm of wasps appears next to it and begins attacking its enemies.
  • Exalted:
    • The spell Flying Guillotine takes blood from an already open wound and turns it into a blade that flies across the battlefield, decapitating people.
    • The Abyssal Exalted are able to extrude chains of their own blood to use as weapons or just tentacles. On a side note, one of their martial arts specializes in whips, chains and bondage. Yes, they're compatible.
    • One set of Green Sun Prince charms allow them to control liquid. This include spilled blood, and there are tons of it on the battlefield. A Blob Monster made of blood is one of the nastier things they can sic at their enemies.
    • Dragon Kings who walk the Coagulated Eucharist Path can learn to, in order, drink other creatures' blood to gain Essence, learn the desires or fears of those whose blood they drink, extend whiplike tentacles of blood from their own wounds, place those grappled by such a tentacle under magical control, and grant enhanced healing and disease resistance to those who drink their blood with the caveat of being able to cause them harm or intoxication at the blood giver's whim.
  • In Fabula Ultima, the villainous vampire Carmilla can attack with swords made of blood in her first phase. She loses this ability in her second phase but gains an offensive "Bloodchill Wave" spell in its place.
  • Games Workshop games:
    • The siege rules for previous editions of Warhammer had the Dark Elves poured boiling blood rather than boiling oil upon their opponents. While not as dangerous in damage potential it had psychological effects on the opponents.
    • Mordheim:
      • One of the spells was available to Magisters of the Cult of the Possessed is "Dark Blood" and literally consisted of the caster slashing open a palm and showering an enemy with blood, which bursts into flame in mid-air. And then testing to see if you collapse from blood loss.
      • The blackblood mutation, available to Mutants and Possessed of the Cult of the Possessed warbands, transforms the model's blood into a highly corrosive substance that burns anyone in close proximity whenever they suffer damage as the tainted blood spurts from the wound.
    • Warhammer Fantasy Roleplay:
      • In the previous edition, trolls were very dangerous to kill because of their stomach acid. Infamously voracious and able to digest everything short of magic items, they had oversized stomach filled with very potent acid. If one was killed with a critical hit to the torso, his belly would burst, dealing massive damage to anyone standing too close.
      • The Blood Substitution Chaos mutation turns a character's blood into another substance. Some of the possible substitutions (e.g. acid, molten metal, mice) can inflict damage on enemies when they wound the character. Apparently you can survive being the victim of this mutation because Chaos Did It.
    • In Warhammer: Age of Sigmar, one of the rewards that a champion of Tzeentch can gain using the Path to Glory campaign rules is for their blood to be transmuted into a strong acid that will wound his enemies whenever the champion takes damage.
    • Warhammer 40,000
      • It is mentioned that Astartes blood is toxic, either made that way intentionally, or as a side effect of their many, many, MANY alterations to make them superhuman. This is hardly an unexpected trait for inhuman Super Soldiers who also secrete acid saliva and are capable of eating a healthy diet of, among other things, concrete and metal.
      • Some Librarians of the Blood Angels Astartes Chapter and their successor chapters are able to boil the blood in their enemy's veins and cause it to explosively burst from their pores. In-game this is represented by the Sanguinary Discipline Psychic Power Blood Boil that could instantly kill the targetnote  or cause multiple mortal woundsnote .
      • In an older edition of the Tyranid codex, some large Tyranid beasties could buy "acid blood" as an upgrade. When killed they would damage nearby units.
      • The Heretic Astartes who, in addition to being supersoldiers, worship gods that give mutations as gifts, and thus have some bad stuff in their blood. Specifically Noise Marines, whose blood is most likely about 50% combat stimms (many of which are probably not too healthy for a normal person to touch), or Plague Marines, whose blood is full of many, many horrific diseases.
  • Legend of the Five Rings:
    • Maho-tsukai, or bloodwitches, who use their specific magic discipline is fueled by blood, sometimes their own (but usually those of unwilling victims), to accomplish all 5. They are ALWAYS evil, in this morally gray setting.
    • One particular type of Oni has flaming blood, and anyone who strikes the Oni with a sword must dodge to avoid being set on fire.
    • Being exposed to the blood of Tainted creatures almost always carries the risk of becoming Tainted.
  • New World of Darkness:
    • Blood Bathers: Immortal people who become... immortal by bathing in people's blood. Besides being a sterling example of Immortality Immorality — even moreso than the soul-eating Tremere Liches — they often gain powers over blood by virtue of it.
    • Similarly, if the Stigmata Key from Geist: The Sin-Eaters doesn't deal with ghosts, then it deals with blood, usually in this sense. Some uses include the Stigmata Curse (which causes a person to bleed constantly from their fingernails for days), the Stigmata Caul (which allows a Sin-Eater to move their blood, detach their arm and remote control it, and create a miniature blood homunculus) and the Stigmata Rage (which not only hurts someone with pure ghostly force, but makes sure their wounds won't close easily).
  • Orbis Aerden Reign Of The Accursed: All the Godspawn bloodlines need Haema (blood) to survive and power most of their inherent abilites, but the aristocratic Vorkai take it a step further. Their specific bloodline power allows them to manipulate the blood in other creatures' veins from a distance and even create weapons and armor from it. The most powerful users can even use their own blood to create semi-intelligent blood golems to fight for them.
  • Pathfinder:
    • A heavily downplayed version of this with the Angelic Blood feat, which only aasimar (people with celestial heritage somewhere in their recent family history) can take. The feat represents their blood being infused with the holy power of their ancestor, which in addition to some minor resistances results in any undead or being with the evil descriptor (such as demons or devils) adjacent to them take 1 point of damage whenever the aasimar suffers damage that is specifically related to blood (hitting you with a sword is not enough, but hitting you with a sword that causes you to bleed enough to take further damage from that is).
    • There are also several spells that weaponize a creature's blood, such as Blood Blaze and Caustic Blood (the target's blood damages nearby creatures when spilled), and Blood Boil (boils the target's blood, dealing a severe amount of damage).
  • The Unofficial Hollow Knight RPG:
    • The Bloodboil spell causes blood-soaked weapons to burst into flame, making those weapons deal bonus fire damage. It can also be cast directly on a creature to damage them if they are also covered in blood.
    • The Toxic Blood trait makes a bug's blood caustic, spraying out at any enemy that damages them to inflict a damaging status effect.
  • Vampire: The Masquerade:
    • There are quite a few Disciplines that allowed the player to weaponize blood. The Assimite Discipline, Quietus, had a power that allowed the user to turn their blood into a deadly acid, and the Tremere Discipline of Blood Thaumaturgy allowed them to control another person's blood (up to and including boiling it). The Tzimisce, meanwhile, could turn themselves into blood, and at a higher level than that could make the blood in their veins acidic — while this made it impossible to create new vampires or ghouls, effectively rendering htem sterile, it also rendered diablerie (soul draining) next to impossible as well (which, given that a vampire that powerful was likely very, very old, was quite important to ensure).
    • The Kuei-jin have Blood Shintai, essentially a grab-bag of all of the above, from making their own bodies constrict or swell, creating whips of blood, or turning others' blood into poison.
  • In Vampire: The Requiem, the Norvegi have a discipline that allows them to mod their own bodies and craft their crystallized blood and bones into blades or armour. At the highest level they cause blood in their bodies to erupt into spikes that shoot out in all directions, impaling anyone nearby. It is also noted to hurt the using vampire as hell (unless a critical success is obtained) and destroys their clothing.
  • World Tree Inverted. The core rulebook has an available flaw a character can take that makes the character's blood burst into flames if exposed to excess oxygen. Carrying oxygen for respiratory purposes is fine, but bleeding causes it to light up. The reason this is an Inversion is characters that take it are not immune to the fire. Anything that draws blood will also burn. Because stone and metal are too rare to use as weapons, anyone with a sword that drew blood now has a sword that can draw blood and is on fire.

    Video Games 
  • Age of Mythology:
    • In the Titans expansion, there are the Lampades nymphs (Hecate's myth unit). When they are killed, they explode in a spray of yellow-green blood. Normally, it's not harmful, but if you shell out the resources for the right improvement...
    • The Egyptian Scarab also can hurt units with its blood when defeated.
  • The final boss of Alisia Dragoon fires blood 'bullets' from his exposed heart at the heroine.
  • Batman: Arkham City has The Joker inject Batman with his own, TITAN infected blood, which would have killed him in under ten hours, had it gone untreated.
  • Arknights:
    • Dikaiopolis got his title of Blood Knight for a reason: His Originium Arts lets him manipulate blood to create weapons or to forcibly exsanguinate an opponent.
    • The current Sanguinarch - leader of the Vampire Sarkaz - is a master of blood Arts, with his known feats ranging from parasitic blood that creates mooks upon death to disintegrating groups of people and leaving nothing behind. For bonus Castlevania reference, Episode 13 reveals that his actual name is Dracul, the Crimson Prince.
  • One of the enemies in Bio-Hazard Battle is a heart with spider legs. It shoots out blood cells that home in on you.
  • BlazBlue: Central Fiction gives us Naoto Kurogane, whose Drive, "Bloodedge" allows him to make weapons out of his own blood.
  • Blood is weaponised in a variety of ways in The Binding of Isaac by both the player and enemies, from simply firing globs of blood instead of tears to creating damaging pools of blood to firing laser-like geysers from whatever orifice they have available.
  • Surprisingly uncommon in Bloodborne, considering how prominent blood is in the game, but it does pop up a couple of times. Queen Yharnam uses her blood as a weapon in her fight, either by spraying toxic blood or by fashioning blades out of it. In the Old Hunters DLC, Maria also powers up her swordplay with blood magic in her battle, which she learned from the Cainhursts.
    • The player can get in on the action with the Chikage, a Cainhurst weapon that's halfway between a cavalry sabre and a katana. Its trick weapon mode involves magically coating its blade in your blood, draining your health over time but slightly boosting your attack range and massively boosting your damage.
    • And then there's Bloodletter, a spiked mace that the user can turn into a giant morningstar by impaling themselves straight through the heart. The supernatural effects of the weapon mean this only damages them once instead of killing them, and the result is a ball of crystallized blood and guts. There's even a special transformation attack where the user turns their back to the opponent and then stabs themselves so the end of the morningstar bursts out of their back and into the surprised opponent.
  • The Carpathian Dragons from BloodRayne 2 are handguns which use blood instead of bullets. Rayne can refill them by stabbing them into enemies, or use her own blood in a pinch.
  • Bloodstained: Ritual of the Night: Boss and playable character Bloodless the vampire uses blood to attack with, doing everything from creating umbrellas (and her dress) from blood to unleashing massive tornados and rains of blood for massive pain.
  • Unlike his original Castlevania counterpart, Dracula in Castlevania: Lords of Shadow timeline controls his own blood to form a whip as main weapon. He can also turn his blood into projectiles or even the elaborate longcoat he's seen wearing most of the time.
  • Sgt. Billie Church from Clive Barker's Jericho is a blood mage. And a Ninja.
  • Jedah Dohma from Darkstalkers fits into this. All of his EX attacks involve turning his blood into a mass of giant hands to grab and abuse his opponent. Or he can rip his head off and spray his enemies with the blood from his wound.
  • In Death Stranding, the many Beached Things that stand in your way react very poorly to Sam's body due to his status as a "repatriate" (someone who's able to resurrect from death), so throughout many points in the game, Sam stock ups on forming anti-BT weapons coated with his bodily fluids, from shower water, urine, feces, and most prominently, his blood. This sometimes works as a handy way to stabilize difficulty following a rough encounter as it means Sam can come better equipped for the next one, but this also means that sometimes, the player will have no choice but to sacrifice some blood voluntarily to deal with something expected to be really big.
  • Deep Rock Galactic: Played with the Glyphid Septic Spreader, which doesn't shoot the usual blood per se, but fires globs of corrosive sepsis that make hazardous puddles. According to the Miner's Manual, that stuff is actually pus, aka infected white blood cells.
  • Lord Erebus of Demigod has an upgrade that turns his blood to poison, increasing his health regeneration and dropping a poison potion on death that damages, rather than heals the collector.
  • Devil May Cry 5 has Dr. Faust, which gives Dante some control over Red Orbs, AKA crystallized demon blood, which he can use to both deal damage to enemies by throwing the orbs at demons, or make enemies he attacks drop more orbs when hit. Red orbs are also used to buy new abilities and items in the shop, which makes it double as Abnormal Ammo and Money Mauling.
  • Diablo II's Necromancer has the Blood Golem skill as part of his Summoning skilltree.
  • In Disgaea 4, one of the succubus' magichange attacks has her strip in front of the party member that was wielding her, resulting in a massive Nosebleed that damages, if not outright kills enemies in front of said party member.
  • Divinity: Original Sin II features Voidwoken enemies, whose blood is cursed. Killing them will create a Cursed Blood surface (which applies Decaying), or if the Voidwoken was already on top of a surface, its blood will end up cursing it (or turning it back to normal if the surface was blessed).
  • Sacriers from Dofus can use their blood to drag enemies towards them.
  • Bloodseeker in Dota 2, as his name suggests, utilizes a lot of blood magic to devastate his enemies, starting from inducing blood lust to empower his target at a cost, spraying an area with blood to eventually silence his enemies, and also flaying the enemy alive, causing blood to gush around them and damaging them further if they walk.
  • In Dragon Age: Origins, the Blood Mage specialization allows a mage to use his own blood (as represented by HP) to cast spells instead of mana. They can also boil their enemies' blood in their veins, paralyzing and injuring them. Or any mage can gain the Power of Blood ability to drain their hit points to replenish their magic rather bloodily if they pick the Dark Sustenance ability from the Warden's Keep expansion.
  • The Berserker subclass of Dungeon Fighter Online has several skills that inflict the bleeding status. The ultimate attack of the Hellbringer, an awakened Berserker, involves summoning a sword made of his own blood. Their second awakening, Blood Evil, learns to explode their blood which does more damage the less HP they have, create a giant orb of blood to crash down on enemies and turn into a giant demon made out of blood to attack their enemies.
  • The tool of the trade for Blood Assassins in Dungeon Siege II: Broken World. They have both the Bloodsoaked Shots passive ability (which increases damage at the cost of health) and the Ravaging Strike ability, which causes a large amount of damage that drains 40% of the user's health, and with the correct upgrade, it can set the target on fire.
  • Dwarf Fortress:
    • The new version includes randomly generated "forgotten beasts" (and other similar creatures) which occasionally have poisonous blood. Dwarves can't be bothered to clean up blood, instead tracking it all over the place and causing the entire fortress to be infected. Hilarity Ensues.
    • There are also subterranean creature called "blood man": human shaped and sized being made entirely of blood. They're far less intimidating than they sound though, as being made of liquid makes them too soft to damage anything and they're torn apart by pretty much any attack.
    • In addition, in adventure mode you can pick up blood from the floor and, like nearly all items, throw it. If your character has high enough strength and throwing skill the flying blood can fracture bones.
  • Pretty much anything to do with Mohg and the Formless Mother from Elden Ring uses blood as a weapon - either the Formless Mother's, or the user's. This can include cutting yourself to shoot a stream of blood at your opponent, or cutting the Formless Mother to manifest burning blood, among other tricks.
  • Ikumi Amasawa of Eternal Fighter Zero uses her own blood as well as the blood of her victims for her special attacks, such as plunging her own blood into the ground to call forth an erupting fountain of blood.
  • Feral Ghoul Reavers in Fallout 3 (only appearing when Broken Steel is installed) throw gobs of explosive, radioactive gore as a ranged attack.
  • Fate/Grand Order: Queen Medb regularly has sex with men. She can somehow store their genetic material in her body. Then when she spills her own blood on the ground, soldiers emerge from each drop, each her sons.
  • The main bosses of Grandia II are the parts of Valmar (read: Satan) — individual representations of a demonic entity's anatomy. Valmar's Heart is just that: a giant, floating heart which spews blood from its open arteries.
  • Grey Area (2023): The third boss, the Goddess of Ichor, can weaponize her own blood. One attack causes a blood vortex which rains droplets from above, and another has her rip her own arm off to attack with the arterial spray.
  • Guild Wars has Necromancers, which have an entire skillset (blood magic) devoted to this. And even many of the skills outside of blood magic still require sacrifice of life points to operate.
  • Testament from Guilty Gear has a scythe made out of their own blood. Their sprite shows that there's a hole in their hand that they draw the blood out of. One of their special moves involves cutting themselves and forming a web out of the blood spray, to trap their opponent.
  • One of the Hydra units in Heroes of Might and Magic 5 has acid blood, allowing them to harm any creature that attacks them in melee.
  • KAEDE Smith in Killer7 has the special move "Blood Shower" during which she cuts her own wrists spraying blood everywhere and unveiling any hidden passages.
  • Kingdom of Loathing:
    • Two skills in the Haemoturgy branch of the Dark Gyffte challenge path (basically, a New Game Plus where the player is reincarnated as a vampire) are variants of Projectile Blood. Blood Chains involves stunning the opponent with a giant chain made of blood, while Blood Spike creates a huge spike of blood that deals physical damage. The description for the latter has a dry quip that can be applied to this trope in general:
      Sometimes a wound causes bleeding, sometimes it's the other way around.
    • Blood Cloak, from the same skill branch, inverts this; this is using blood to avoid combat.
    • Player who completed Dark Gyffte while it was in-season got a "Booke of Vampyric Knowledge" skillbook, which granted different skills depending on class. All are themed around Cast From HP, and some of them also embody this trope. For example, Disco Bandits (Dance Battler crossed with Blade Enthusiast) got Blood Blade, which solidifies their blood into a knife with extraordinarily high base damage but no other enchantments, while Pastamancers (Chef of Iron-types with skills themed around magical pasta) got Blood Bucatini, which turns their blood into pasta that causes fairly low damage but also lowers opponents' attack and defense.
  • In The King of Fighters, Lin, a Chinese ninja, has his blood type listed as "poison". In gameplay terms, this means that some of his moves involve momentarily covering his hands with his blood in a way that makes it look like he's wearing surgeon's gloves made out of blood, and he has a super move that poisons the opponent. Turning the blood off from options turns it green instead, and makes his winning portrait look like his hands are covered in snot.
  • Kirby:
    • This is one of Zero's attacks in Kirby's Dream Land 3. Yes, you read that correctly. The True Final Boss of a K-A rated SNES game cuts itself so its blood will attack Kirby... and also rips out its own bloody iris as a last-ditch attempt to kill Kirby.
    • And then cue Zero Two in Kirby 64: The Crystal Shards. Its official art shows it crying blood, to be expected since it's more-or-less a reincarnation of Zero; moreover, the tips of its wings are crimson-red and look like they're soaked with the stuff. It also splatters about whenever you hit Zero Two in its eye — however, due to the graphics this can be mistaken for red energy or explosions.
  • League of Legends has Vladimir, the Crimson Reaper, who is described as a "Hemomancer". He can drain life, throw deadly streams of blood, temporarily melt into a pool of blood, and infect enemies with a deadly "Hemoplague", which weakens and damages them.
  • The flash game Medieval Rampage 2 demonstrates this in its most basic form—kill various types of monsters, and they leave behind various types of unpleasant goop that you're better off not stepping in. Initially, you just encounter black goop that somehow blinds you and orange goop that slows you down, but green blood (identified as "acid" in the achievement list) actually damages you if you touch it. The overall effect is to constrain your movements as the waves of enemies get thicker and thicker.
  • The Metal Slug series has a zombie apocalypse stage in some of its iterations. When you get hit by a zombie you don't die immediately, but you become a lumbering zombie yourself. Your gun as a zombie is crap but your grenades become a stream of blood that your character vomits in an arc that sweeps over half of the screen, and it's also one of the most powerful attacks in the series.
  • Monolith has many enemies (namely Lost Souls, which seem to be composed of blood as well) that fire bullets made of blood.
  • Baruragaru from Monster Hunter Frontier is a Leviathan that weaponizes the blood it sucks from Bird Wyverns such as Velocidrome, Gendrome and Iodrome into various attacks. Such as an attribute-lowering attack with Velocidrome blood, paralyzing strikes with Gendrome blood and poisonous mists with the Iodrome's blood. It can also drain the hunter of blood and use it for attacks, too.
  • Mortal Kombat:
    • Mortal Kombat: Deadly Alliance: This game introduces the vampire Nitara whose projectile move is a ball of blood she fires from her mouth.
    • Mortal Kombat 9 Skarlet uses her own blood as a weapon and is herself a creature made of bloodnote . Noob Saibot in the same game bleeds a black inky substance that he also uses to create the clones that he uses in his attacks.
  • Wyrm Masters in Nexus Clash have acid blood that consciously seeks to cling to whoever spilled it. Fighting one with a sword or arrows is a bad idea; it's better to use fists, fire or some sort of Holy Hand Grenade.
  • Not Dying Today have the B.G. Nurse, a powerful zombie boss, who can puke a pillar of blood as a melee attaack covering a large portion of a screen. Said attack seems to be lifted directly from Metal Slug above.
  • From Pokémon Ruby and Sapphire onwards, there's the Liquid Ooze ability. Any Pokémon that uses a health-draining attack on a Pokémon with this ability will take damage instead of regaining health.
  • Remorse: The List have the Blood Demon enemies, Boss in Mook Clothing elementals made of blood who can fling puddles of blood at you. Not only are the blood corrosive, but if it misses it's mark, the blood will somehow sprout bloody spikes that can damage you.
  • Resident Evil:
  • Riftblade warriors in Rift can learn the ability "Burning Blood," which causes any Critical Hit on the warrior to damage their opponent as well.
  • Charlotte from Rumble Pack uses blood for some attacks. Since she is a vampire, it is unclear whether the blood is her own or comes from her victims.
  • The Sanguimancer of Salt and Sacrifice, as his name suggests, can conjure blood in order to attack the player. Fortunately, he lacks the ability to control the player's blood.
  • The Secret World has Blood Magic, which is good for boiling enemies' blood, attacking them with spikes of congealed blood... and healing and shielding your allies.
  • Skullgirls:
  • Soul Sacrifice has one type of spell which allows you to fire a spray of blood, dealing damage at the cost of constantly draining your HP while firing. There are two variations of the spell; one is a scattershot that covers a wide area, the other a series of slashes by holding down the command. With exception to the protagonist, the only character who keeps this in their move set is Aegrus. It's also the only spell which can be used without limitation (besides running out of health).
  • The Mainliners from The Suffering are, essentially, the embodiments of death by lethal injection, so they don't have any blood in the proper sense, instead leaking a greenish fluid that burns you if you step in it. They indirectly use this as an attack as well — the same fluid is contained in syringes that stick out of their backs like porcupine quills, which they either throw from a distance or stab you with for massive damage.
  • Terraria : Despite the unfortunate name, the Golden Shower weapon actually fires a yellow stream of "ichor", which is basically highly corrosive demon blood. It does decent damage per second, especially paired with the fact that it causes a debuff that lowers the target's defense.
  • Touhou Project:
    • Remilia Scarlet is another vampire capable of weaponizing blood. As Marisa said in her Grimoire, "Blood is amazing".
    • The blood of a Celestial is poisonous to Youkai. Hilarity Ensues when Remilia tries to drink Tenshi's blood in the fancomic Touhou Nekokayou.
  • The Big Bad of Akiha's path in Tsukihime can turn his blood into swords. Even at a distance. Even when it's soaked into your shirt.
  • In Turok 2, there are zombie enemies that can throw blood at you. If you go to the options screen and turn the blood off, this section becomes a lot easier.
  • Carmine of Under Night In-Birth wields his own blood as a weapon (as well as hair dye), whether crystalized (normal attacks) or liquid (special attacks, which are usually Cast from Hit Points and leave temporary blood pools to empower further attacks).
  • The Warcraft 3 custom map Tides of Blood has a hero known as the Blood Mage, which is different from the standard Blood Mage in that his title is a bit more literal. He can use his own HP to summon geysers of blood and "Blood Elementals". His ultimate technique is, naturally, Tides of Blood.
  • In The Witcher series, the Black Blood potion lets Geralt and other witchers turn vampires' Horror Hunger against them, by making their own blood corrosive and poisonous to vampires if they try to feed. In fact, the Black Blood potion that Geralt uses in the "A Night to Remember" trailer is the key to him defeating the bruxa he's fighting. Naturally, this potion would horrifically kill any normal human who tries to imbibe it, but witchers are much more than human.
  • Wizardry 8 has Level 6 Fire spell Boiling Blood, which does considerable fire damage to one target, and should they be killed by it, they explode violently and damage nearby enemies as well. A gadgeteer class has an access to Microwave emittor, which is somehow obtained by putting a chip from destroyed microwave into a broken blaster and basically does the same.
  • World of Warcraft:
    • Death knights get Blood Horrors, Boiling Blood, and Blood Boost. Though they gain power from the spilling of their enemies' blood as well as their own.
    • Deathbringer Saurfang, strongest Death Knight of the Lich King, is a Blood death knight turned up to eleven.
    • The Old Gods' blood can spawn Horrors. After it hardens, it can be mined and used to craft weapons, armor and even buildings. Prolonged exposure may lead to insanity.
    • Deathwing bleeds Old God-corrupted magma which is highly corrosive and spawns Horrors.
    • Nespirah's blood cells are big enough to absorb most humanoids. It means no harm, but only has limited control over its bodily functions.
    • Hakkar's Corrupted Blood was not only highly toxic, but infectious enough to turn into a full-fledged pandemic.

    Visual Novels 
  • The dragon in Dra+Koi turns her blood acidic in order to fight the hero that much more effectively.
  • In ClockUp's Maggot Baits, we have Brutal Edge:
    Name given to the Witches' signature weapons.
    Made of a Witch's coagulated blood, naturally imbued with power.
    Sword, axe, spear; they take many forms, all intended to shed great quantities of blood.
    In the hands of a Witch, they exhibit a destructive power that transcends the laws of physics.
    Destroying one will cause a Witch to lose a lot of her power, greatly weakening her.

  • In The Adventures of Dr. McNinja, Dr. McNinja's father stores up poison in his blood so that he can shoot it out of his eyes like a lizard.
  • Blood is Mine: Jane can control anything that her blood is inside of, including people. She can see through their eyes, speak to them telepathically, modify their bodies, dig through their memories, and use their skills. Eventually, she learns to produce and manipulate all kinds of biomatter.
  • Drowtales: Blood is one of the various elemental affinities drow can have. One of the main characters, Chrys'tel, has a well-developed blood affinity and uses it to create what are essentially grenades by filling vials with blood (largely her own) and throwing them at opponents, making them explode when close enough.
  • Enemy Quest: Much like the Xenomorphs of Alien fame the alien Skut possess acidic blood. They put it to lethal effect during the war, as their status as the invading Visitor's Action Bomb meant that anyone who their blasts didn't get would end up splashed with the stuff.
  • The protagonist of Erfworld, Parson, lies to his captors that his blood functions as a potent contact poison. Given that people in Erfworld do not bleed externally like they do in real life (where Parson is from), the enemy Warlord is not willing to risk spilling his blood.
  • Used to terrifying effect in Flipside.
  • JoJopolis: Rose Speedwagon's Stand, Love Like Blood, gives her full control over her circulatory system, including manipulating her veins like tentacles, shooting blood like a projectile, and increasing its temperature hot enough to cause burns.
  • Though it's never actually been weaponized (yet), Joey's blood from Mortifer burns whatever it touches. It can even light stuff on fire, if left too long. This actually inconveniences him more than anyone else, though.
    Joey: I don't think you understand the difficulties I have. Fire-proof eyepatch, fire-proof gloves, fire-proof clothes... Just to keep them from melting whenever I get a scratch.
  • The Secreted Weapons of Doyt Gyo in Schlock Mercenary. Not limited to fluids; his... solid products are explosive.
  • Mr. Jinx in Starslip, among numerous other Bizarre Alien Biology traits, has corrosive blood that can actually be ejected from his eyes, and as another character unpleasantly discovers, his blood is alkaline, not acid.
  • Zebra Girl: All of Sandra's bodily fluids are highly acidic. Her blood's also something of a drug to vampires.

    Web Original 
  • Madgie, what did you do?: Toki's blood is apparently toxic, considering that when it ends up in the bloodstream of someone who isn't her sister (or baby), it can turn them to crystal. This is a variant in that, while toxic, it has to get into a person for the effect to work. At the same, it also causes flowers to sprout, as demonstrated in one story.
  • The Fair Folk in Moonflowers have corrosive blood — it burns humans and can eat through the metal of a car enough to require extensive repairs. It also goes the other way: human blood will burn fairies on contact if the human has recently eaten rock-salt.
  • In Mortasheen, the Viviphage has the power to control blood, ripping out the blood of its victims. It also happens to be the ultimate form of the Vampire race and look like a bacteriophage. There's also the Mothneaser, one of the game's Olympus Mons that produces massive quantities of blood that it doesn't just turn into weapons or horrible "blood golems" but also can insert tendrils of its own blood into people to puppeteer their bodies.
  • Whateley Universe:
    • Forget mere acid blood. Tennyo has anti-matter (or something scientists cannot distinguish from anti-matter) in her cells, so she can release anti-matter into her blood when she wants to. It doesn't ever harm her, but you don't want to be hit by her blood if she gets injured. (Note that this doesn't usually seem to be a major issue because she heals just that damn fast — but there is one canon scene where she deliberately bites her lip to shatter a block of solid ice she and a teammate are encased in because she's worried about just cutting loose with her energy blasts. It works.)
    • While on the subject of Whateley, in Hawthorne Cottage (the one for those students who really can't easily lead a normal life even for mutants) there lives a girl who has poisonous blood, but no immunity to it. She can't ever leave her room because she's hooked up to life support and her blood is so incredibly toxic that visitors or cleaning personnel have to wear sealed suits and follow strict biohazard protocols. Compared to her, many of the other kids at Hawthorne (to say nothing of other students who have trouble adjusting to their mutation-induced changes) have it easy.

    Web Videos 

    Western Animation 
  • A throwaway gag in Family Guy involved showing a video on how to identify gay people. One indicator was ownership of a Madonna album; the other was having "deadly corrosive acid instead of blood."
  • Transformers: Animated: Given how Energon is both used as Symbolic Blood and the standard fuel sources for both all Cybertronians and their various guns, one can consider Optimus Prime's Energon axe to be made out of his own "blood" formed into a laser axe.

    Real Life 
  • Several species of horned lizards squirt streams of blood (for a distance up to 3ft!) from the corners of their eyes as a self-defense mechanism. They're quite accurate with spraying it at a predator's eyes and mouth, and it apparently has an an unpalatable flavor to dogs and cats.
  • There are many criminal cases stemming from a perpetrator with a blood-borne disease purposely having intercourse with, bleeding on, or stabbing victims with used needles.
  • In 1994, a woman named Gloria Ramirez suffering from late-stage cervical cancer was brought to a hospital in California. When one of the nurses treating her tried to draw blood, she noticed a strong smell of ammonia. One of the doctors then noticed small particles in the blood. A few minutes later, the nurse fainted, and shortly after that, the doctor got sick to her stomach and fainted herself. A few minutes after that, somebody else fainted. Months later, Livermore Laboratories concluded that the woman had been taking dimethyl sulfoxide for pain, which had been building up in her bloodstream due to a urinary blockage and that her treatment in the emergency room caused it to turn into dimethyl sulfate, a poisonous gas.
  • Eel blood is toxic to humans. It can be safely eaten, as both cooking and the digestive process destroys the toxicity, but should it come into contact with the bloodstream via another means will cause anaphylaxis.


Video Example(s):



Power, the Blood Fiend, is all too eager to fight and kill other Devils.

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Main / BloodKnight

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