Lara Croft of Tomb Raider has had four voice actresses over 12 years and 8 games, each one bringing a totally different spin on Lara's personality. She even changes in appearance, and has been played in live action promo shots by at least five different women, not even counting Angelina Jolie and Alicia Vikander in the film adaptions. She pretty much must be a Time Lord.
This is done deliberately so that no actress will be able to dominate the character.
Sofia Vergara played what is essentially the Jolie version of the character in this TV spot for Visa credit cards.
Max in Sam & Max Save The World had his voice replaced after the first episode, though the voices are so similar it's not really that important - some of the original actor's voice clips have even been retained.
Before the big cast change, Tails went through several voice actors that were actual children (3 in English and 2 in Japanese), while Knuckles was voiced by Michael McGaharn in Sonic Adventure, Ryan Drummond (who also voiced Sonic) in Sonic Shuffle, and Scott Drier from Adventure 2 to Heroes.
Ultimately, if you count the short voice clips in Sonic CD, you would find that Sega has gone through 5 voice actors for Sonic. That's a lot compared to others.
Big the Cat was voiced by the late Shun Yashiro in Sonic Adventure and Takashi Nagasako everywhere else.
Not counting the cartoons, the first time Sonic got a dub in Italian was in Sonic Generations. Since then, the voices were kinda consistent... except for Shadow. Only in Generations, Shadow was voiced by Maurizio Merluzzo (who also voices Knuckles) during his rival battle and by Riccardo Lombardo for the remainder of the game. In subsequent games, Claudio Moneta voiced the character, except in Super Smash Bros. for Wii U and 3DS where Riccardo Lombardo took the role back.
The entire English cast of Valkyrie Profile changed between the first game and the second due to a switch in dubbing groups (TAJ Productions did the first game; Bang Zoom! Entertainment did the second). The only exception was Valkyrie Lenneth's voice actress, Megan Hollingshead, who voiced her in both games; this was actually because Hollingshead had transitioned from TAJ/4Kids Entertainment (New York) to Bang Zoom! (California) a few years after the first game was released. Also, Kikuko Inoue voiced Valkyrie Hrist in the first game, and Atsuko Tanaka in the second.
The same could be said of every recurring character excluding Lady (who has kept Kari Wahlgren as her voice actress since 3, though she too had a different voice in The Animated Series). The aforementioned Dante example is muddled further if one considers Dante's Special Guest appearance in the PlayStation 2 version of Viewtiful Joe. Although it came out a year after Devil May Cry 2 (where he was voiced by Matthew Kaminsky), Dante is instead voiced by his Devil May Cry voice actor (Drew Coombs). Thus, the voice actor progression went from Drew Coombs, to Matthew Kaminsky, then back to Drew Coombs, and then finally to Reuben Langdon, who has stayed as Dante's voice since the third game.
Devil May Cry 2 also features Dante's outfit from the first game as an unlockable costume; when using this outfit, his voice clips in normal gameplay are replaced with those of Drew Coombs from the first game.
Sarah Kerrigan, the penultimate Big Bad from the first StarCraft, is now voiced by Tricia Helfer for the ongoing StarCraft II sequel trilogy. Notably a flashback cinematic in the Wings of Liberty campaign, which featured Kerrigan's lines from the first StarCraft Terran campaign by her original voice actress Glynnis Talken-Campbell, were entirely redubbed by Helfer. Fred Tatasciore has taken over the role for Zeratul, as the original voice actor Jack Ritschel had passed away sometime before the production of Starcraft II. Patrick Seitz is the voice actor for Artanis in StarCraft II. All in all, only the voice actors for Jim Raynor and Arcturus Mengsk got to keep their roles from the original installment.
Jim Raynor had a different voice actor complete with a very pronounced Southern accent in the initial gameplay trailers released for StarCraft II. Interestingly, Blizzard eventually changed their minds and brought back the original voice actor, Robert Clatworthy. But in a bizarre twist, Talken-Campbell initially confirmed that she was supposed to play Kerrigan in StarCraft II all along, and a released trailer showcasing storyboard sketches for the flashback cinematic actually featured her voice (and the redubbed lines for Jim Raynor complete with the Southern twang). Sometime after Clatworthy announced his reinstatement as the voice of Jim Raynor, Talken-Campbell took to the internet and announced that Blizzard decided to replace her as the voice for Sarah Kerrigan. Subsequent fan backlash never swayed the developers to reconsider their decision.
Goodson even voiced him in a ten-second cameo appearance in Soul Nomad & the World Eaters where Laharl wasn't even seen. It doesn't help that she voices another kid character with the same voice she uses for Laharl.
Also from the same series (and most other Nippon Ichi games as well) there's Asagi. She is voiced by a different voice actor in EVERY SINGLE APPEARANCE. This is done deliberately and the one time they reused a voice actor she outright says "I'm being voiced by the same person for the first time, dood."
In an unusual inversion, when Lunar: The Silver Star, was being remade into Silver Star Story, the original five English actors who did the original returned (along with other local talent from the area the Working Designs studio was), while all four Japanese voice actors from the original were replaced with an entirely new cast. The most notable change was Alex originally having Kikuko Inoue, and then going to Akira Ishida.
This occurs again in the Silver Star Harmony remake for the PSP, which was localized XSEED Games instead, as Working Designs had long gone out of business. The story as to why depends on who you talked to - Victor Ireland, the former head of Working Designs, claimed the entire voice cast was loyal to him, aside from Jenny Stigle who "broke rank". XSEED, on the other hand, stated that most of the old cast wasn't actually in the business anymore, hence they hadn't tried to find them. Accordingly, Stigle got involved because fans of the original games put her in touch with XSEED. So which story you believe depends on who you trust more, though it was no secret that Ireland had a very bitter falling out with XSEED during the localization process.
The sequel, Lunar: Eternal Blue, maintained consistent casts for both languages, on the other hand. The only change was Hiro's English voice going from Mark Zempel (Eternal Blue) to Chad Letts (Eternal Blue Complete), but they sound similar to the point that they're almost indistinguishable.
Interesting international tidbit: the voice actor for the Spanish voice track was changed between Sands and Warrior, and the one from Warrior remained for Two Thrones. But what's interesting is that the first voice actor sounds younger and more arrogant, while the second voice actor sounds grimmer and older... which fits perfectly with the timeline of the game, since Warrior happens after a noticeable Time Skip, while Two Thrones is immediately after Warrior.
In the 3D The Legend of Zelda titles, Ganondorf was voiced by Takashi Nagasako, but for unknown reasons was replaced by Hironori Miyata in The Legend of Zelda: Twilight Princess. This is more noticeable because unlike Link, Zelda, and other recurring characters, Ganondorf is confirmed to always be the same person in each game. Then again, a lot of fans probably didn't notice due to the series' lack of extensive voice acting.
Every Star Fox game has a different American (or in Star Fox Adventures's case, British) voice cast; in Super Smash Bros.. Brawl, however, Jim Walker voiced Fox as he did in Star Fox Assault, and in their cameos, Mike McAuliffe returned to voice Slippy, and Alesia Glidewell voiced Krystal (Glidewell also voices Samus in that game.)
The Japanese versions aren't free from this; unlike most examples, though, they extended the cast and made more diverse voices (Star Fox 64 had only six voice actors for its many roles). One example is that Shinobu Satouchi voiced both Fox and Leon in 64; in Assault and Brawl Satouchi keeps Leon, but Kenji Nojima voices Fox instead. The only seiyuus who stayed throughout were Hisao Egawa (Falco), Kyoko Tonguu (Slippy and Katt in 64), and Tomohisa Aso (Peppy).
When the Star Fox 64 remake for the Nintendo 3DS was released, the entire Japanese cast had been replaced, with Egawa, Tonguu, and Aso finally dropping out.
The American version of 3D also changed up the cast again, notably bringing back several members of the original 64 cast.
Partway through the Wrath of The Lich King expansion, Sylvanas was abruptly re-voiced by a new actress who gave her a more prominent accent. Many fans of the character were upset with this, claiming the accent doesn't fit the character.
The voice of Sparx in The Legend of Spyro series changes in each game, from David Spade to Billy West to Wayne Brady. In Dawn of the Dragon, when voiced by Wayne Brady, he tells Spyro that "[his] voice keeps changing" when Spyro asks how he feels.
Also Spyro himself has had many different voice actors as well: Carlos Alazraqui in the first game, Tom Kenny in the second through fourth game, Jess Harnell in the fifth and sixth games, and Elijah Wood in the sixth, seventh and eighth games.
After Spyro left Insomniac, each new game got a cast change for pretty much every recurring character, and often along with it, changes in personality.
The Xenosaga games had three entries in the series, and mixed and matched their actors throughout; for example, Episode 2 replaced Lia Sargent as Shion with Olivia Hack; Bridget Hoffman as KOS-MOS with Colleen O'Shaughnessey; Sherry Lynn as MOMO with Christina Puccelli; and Derek Stephen Prince as Chaos with Joshua Seth. Episode 3 replaced Shion and KOS-MOS with their original voice actors while keeping the rest of the main cast from Episode 2.
For Scarface: The World is Yours, Al Pacino could not reprise his role as Tony Montana as his voice had been altered by years of smoking, so he hand-picked André Sogliuzzo to do the voice acting, although the likeness remains Mr Pacino's. The difference in the voice is very difficult to notice.
Jak's voice actor was replaced in The Lost Frontier (from Mike Erwin to Josh Keaton). Given that early-stage production footage exists in which he's still voiced by his original voice actor, the switch is quite baffling. It seems most fans much prefer the original voice, with some even saying they didn't bother picking up PlayStation All-Stars Battle Royale because Jak is voiced by "the replacement".
Keira, the hero's main love interest, changed voice for the third game (from Anna Garduno to Tara Strong). They decided to try and cover this by only giving her a handful of lines, and shifting Ashelininto the love interest position, despite Ashelin's obvious relationship with Torn providing a key plot point in the previous game. Keira also for some reason got a completely new facial structure along with her new voice.
This has occurred with at least 3 characters in the Monkey Island series. Most notably, the character of Elaine Marley. In Escape from Monkey Island, she not only has a completely different voice actress, but she has also inexplicably dropped her British accent from the previous game. Oddly enough, she has both her original voice actress and her accent back again in Tales of Monkey Island.
In the first chapter of Tales of Monkey Island, LeChuck was voiced by skilled VG voice actor Adam Harrington instead of Earl Boen, who had been voicing the character for years prior, though they managed to get Boen back for chapters 4 and 5.
From Tekken 3 up until Tekken 6, the role of Heihachi Mishima belonged to Daisuke Gori. Following Gōri's suicide, the role was given to Unshou Ishizuka (which also corresponds to Heihachi becoming younger for the release of Tekken Tag Tournament 2).
Also in Kingdom Hearts II, David Warner was invited back to voice his TRON characters Sark and The MCP, and apparently was very enthusiastic about revisiting the roles, but was unable to do so because of previous commitments. The parts were instead voiced by veteran voice actor Corey Burton, with many fans not even realizing it wasn't Warner.
Like with Star Wars, Corey Burton also replaced Christopher Lee as DiZ for RE:Chain of Memories, though this imitations is not as good as others of his. Strangely, Christopher Lee came back as DiZ in 358/2 Days.
Also related to Kingdom Hearts, but not Tron, they had replaced Naminé's Brittany Snow and even Kairi's (of all characters) Hayden Panettiere, with Meaghan Jette Martin and Alyson Stoner respectively, in RE:Chain of Memories and 358/2 Days. Alyson Stoner also voices Xion (it's significant later in the game).
Perhaps most notable of all was the replacement of Ansem's voice actor Billy Zane with the decidedly less hammyRichard Epcar.
Plus in general, the characters voiced by big stars had their original voice actors not return such as Genie (Robin Williams), Mushu (Eddie Murphy), and Phil (Danny DeVito) in Kingdom Hearts (or really any Disney property aside from the original film). Some of them such as James Woods (Hades), Angela Lansbury (Mrs. Potts), and David Ogden Stiers (Cogsworth) did return, however.
This became interesting in II, where two actors (Tate Donovan and Glenn Shadix) reprised roles they didn't in the first game (Hercules and the Mayor of Halloween Town respectively). In other words, they became the other Darrins to their own other Darrins.
Almost the entire cast of The Lion King had new voices in Kingdom Hearts II with the exception of Pumbaa and Banzai and Ed who did have their original voice actors return. Young Simba and Mufasa had their original VA's return by way of reusing audio from the original film. Also the entire cast of Pirates of the Carribean were replaced as the original cast was shooting the sequels and couldn't return (although they did want to).
Unless they got all the voice acting recorded early, it's a pretty safe bet that other Darrins are going to be needed for Master Xehanort in Kingdom Hearts III, both in Japanese and English, due to the unfortunate loss of both Chikao Ohtsuka and Leonard Nimoy.
The 5 main characters of The World Ends with You appear in Kingdom Hearts 3D: Dream Drop Distance, and 4 of them are voiced by their original voices. They are Neku (voiced by Jesse David Corti), Shiki (Heather Hogan Watson), Joshua (Aaron Spann), and Beat (Crawford Wilson). That leaves Rhyme, who was originally voiced by Kate Higgins, but in Dream Drop Distance, she is now voiced by Ashley Rose Orr.
The English version of the spinoff series Dynasty Warriors: Gundam had to recast all the characters, since Bandai couldn't get ahold of the men and women at The Ocean Group to have them reprise their roles. Also, one of the actors had left a long time ago.
In the second game, the voice for Judau changed from Sean Broadhurst to Andrew Francis.
Most of the original voices did return for DWG. The only notable replacements were Louis Chirillo as Heero (Mark Hildreth refuses to reprise the role after bad convention experiences) and Phil Fulton as Domon (Mark Gatha is now a dentist and no longer does voice acting).
Samantha Kelly began in Mario StrikersCharged and is Peach's current actress at this time.
Princess Daisy from Super Mario Land has had Jessica Chisum for her return in Mario Tennis, Jen Taylor for her first three appearances in the Mario Party series, and, starting with Mario Golf: Toadstool Tour, Deanna Mustard, her current actress. And they sound different.
Rosalina had been voiced by Mercedes Rose in Super Mario Galaxy and Mario Kart Wii, and she was voiced by Kerri Kane in Mario Kart 7, Mario Golf: World Tour, the fourth Super Smash Bros., and is currently voiced by Laura Faye Smith. There seems to have been a strange bit of flipflopping between Smith and Kane, as Smith voiced Rosalina in Super Mario 3D World, released before World Tour, but Smith has since gone back to voicing Rosalina for Mario Kart 8 and the tenth Mario Party game.
Although Charles Martinet consistently voices Mario ever since he got the role, there was a flip-flop of voices before he joined.
Toru Furuya, his main Japanese voice actornote except in some commercials, where he's either Takeshi Aono, Gorō Inagaki, Takashi Okamura, or Kazunari Ninomiya.
Any Resident Evil character that has been in more than one game will likely have a different voice actor per game due to Capcom's habit of changing casting agencies. The most notable exception of this was Claire Redfield, who had been voiced by Alyson Court from her debut in Resident Evil 2 (early 1998) until Degeneration (late 2008), until she was replaced in Revelations 2. Court was nearly going to be replaced a lot earlier for Resident Evil – Code: Veronica. When Capcom considered using a local talent agency from Japan for the game, the Canadian studio that provided the voice acting for RE2 and Resident Evil 3: Nemesis successfully lobbied for her return.
Some characters have switched back and forth. Richard Waugh voiced Wesker in Code: Veronica, but was replaced by Peter Jessop in the GameCube version of the first game, only to return in 0 and 4, then he was replaced by D.C. Douglas in 5 and The Umbrella Chronicles.
Sally Cahill, who voiced Ada Wong in Resident Evil 2 and Resident Evil 4, was replaced by Megan Hollingshead in The Umbrella Chronicles, but returned to voice Ada in The Darkside Chronicles, and was then replaced again by Courtenay Taylor for Operation Raccoon City and Resident Evil 6. Most of the regular VAs from the time of 4 onward (including the aforementioned people) also reprised their roles in The Darkside Chronicles, although most of characters from the games before 4 were given new voice actors.
Chris Redfield has been somewhat better in this regard, having four different actors between the original game (Scott McCulloch), Code Veronica (Michael Filipowich), the REmake (Joe Whyte), and The Umbrella Chronicles (supposedly Kevin Dorman), but ever since RE5 he has been consistently voiced by Roger Craig Smith. During his cameo appearance at the end of Resident Evil 7: Biohazard, Smith was darrin'd with David Vaughn assuming the role.
Mortanius from Blood Omen: Legacy of Kain was originally voiced by Tony Jay, who would voice the Elder God in the sequels. To prevent confusion, they had Alastair Duncan voice Mortanius in Defiance.
After a contract disagreement with THQ, Richard Horvitz and Grant Albrecht were replaced as Pox and Crypto for the spin-off game Destroy All Humans!: Big Willy Unleashed. The fans did not take to well to the replacement actors, but the originals came back for later games in the series.
In the Metal Gear Solid remake for GameCube, all the English voice actors from the original game reprised their roles with one notable exception: the voice of the Cyborg Ninja was changed from Greg Eagles, who was credited as George Byrd in the original, to Rob Paulsen. Eagles still reprised his other role as the DARPA Chief for the remake.
When Solid Snake and Roy Campbell appeared in Ape Escape 3, the localization staff were too lazy to track down David Hayter and Paul Eiding to reprise their role, so they got Peter Lurie, incidentally the voice of Vulcan Raven, and Michael McColl respectively.
Similarly, in Metal Gear Solid 3: Snake Eater, Raiden in the Secret Theater's Metal Gear Raiden: Snake Eraser was voiced by Charlie Schlatter, the same voice actor who voiced his Expy, Raikov.
In Metal Gear Solid 3, EVA was voiced by Suzetta Miñet (although, given the reveal that she was actually an alias for another actress, exactly who played her is a subject of debate). However, in Metal Gear Solid: Portable Ops, her voice actress was replaced with Vanessa Marshall for some reason (although to be fair, she never actually got any actual voiced scenes and at best did grunts), and in Metal Gear Solid: Peace Walker, EVA was voiced by Suzetta Minet again.
In Metal Gear Solid 4, Liquid Ocelot's voice actor in the Japanese version was Banjo Ginga (the voice of Liquid Snake), not because of the fact that he was possessed by Liquid (hint, he was faking all along), but because Revolver Ocelot's original Japanese voice (Koji Totani) died before Metal Gear Solid 4 began production.
The English dubs have had three different voice actors for Ocelot in three different periods of the character's life - in his 60s during Metal Gear Solid 1, 2 and 4, he's Patric Zimmerman; in his 20s during Metal Gear Solid 3 and Portable Ops, he's Josh Keaton, and then in his 40s for The Phantom Pain, he's Troy Baker.
Master Miller was originally voiced by Cam Clarke, but the role was recast to Robin Atkin Downes for Metal Gear Solid: Peace Walker. This could be forgiven, though, since it was a thirty-years-younger Miller and Miller died before the events of Metal Gear Solid, with Liquid Snake, also voiced by Clarke, assuming his identity.
The Substance rerelease of Metal Gear Solid 2: Sons of Liberty includes a VR mission where you fight Meryl. For this fight, however, rather than recording new lines, they reused voice clips from Olga Gurlukovich's fight early in the main game. This would have made sense in the Japanese version, as the two characters share the same seiyuu (Kyoko Terase), but every Japanese version of Substance, up until the HD Edition nearly a decade later, just used the English voice acting.
Same for Rosemary's voiceovers in the above "Snake Eraser" short in MGS3, where her lines are all done by the same actor as The Boss - it works in the original because both characters are voiced by Kikuko Inoue, whereas in English it went from Lara Cody to Lori Alan. The Digital Graphic Novel version of MGS2 replaced Rose's voice again, this time with Kari Wahlgren.
Backyard Sports has had four voice casts: 1997-2001, 2002-2003, 2003-2005, and 2006-present. All except 2002-2003 were made up of mostly the same people, but playing different characters each time.
Tenchu: The series in general, in both English and Japanese; they constantly changed studios from game to game. To mention the English examples:
Rikimaru went from Paul Lucas in the first game, to Rino Romano in the second, to Daniel Dae Kim in the third and Liam O'Brien in the fourth.
Ayame went from Terry Osada in the first game, to Debi Mae West in the second, to Michelle Krusiec in the third and an unknown voice actress in the fourth.
As for other characters, Onikage went from Seiichi Hirai in the first game to Paul St Peter in the fourth; while Tatsumaru went from David Moore in the second to Quinton Flynn in the third.
In the Syphon Filter series, Mara Aramov has had four noticeably different voice actresses, the latter two being American rather than native Russian. Lian Xing has been voiced by three actresses; Ava Fang in 1, Zoe Galvez in 2 and 3, and Kim Mai Guest in all subsequent games, complete with different looks and personalities. Gabe Logan also switched voice actors from John Chacon to James Arnold Taylor starting with The Omega Strain.
Magneto and Colossus lose their well-known voice actors (Tony Jay and Earl Boen) for the X-Men Legends sequels, in which they were replaced by Richard Green and Jim Ward respectively. Cyclops and Pyro (both voiced by Robin Atkin Downes) were also recast so Josh Keaton and John Kassir took his roles.
This carried through to the Marvel Ultimate Alliance games, though more noticeably in the second. Some actors stayed on from X-Men Legends, though by the second this became far less frequent and often actors staying on were cast in new roles. By Ultimate Alliance 2, the only actors reprising roles from previous games were Steven Blum as Wolverine, John Kassir as Deadpool, April Stewart as Ms. Marvel, Dawnn Lewis as Storm, and John DiMaggio as Juggernaut. Fred Tatasciore reprised his role as Hulk from elsewhere, replacing Peter Lurie from the previous game.
Al Pacino did not allow EA to use his likeness or voice for The Godfather game, so Michael Corleone's appearance and voice were replaced.
While Street Fighter does this frequently, the most notable cases are...
In the Japanese version of Street Fighter IV, everybody is recast except for Ken (Yuji Kishi from Street Fighter III 3rd Strike onward), Blanka (Yuji Ueda as of Street Fighter Alpha 3), Makoto (voiced by Makoto Tsumura in both of her appearances), Yun (Kentaro Ito from 3rd Strike on), Yang (Masakazu Suzuki from 3rd Strike on) and M. Bison (Norio Wakamoto as of Capcom vs. SNK). Curiously, Yuji Ueda does not reprise his role as Vega, instead being replaced by Junichi Suwabe, and Toru Okawa is no longer Ryu, but his master Gouken.
In Koei's Samurai Warriors, Toyotomi Hideyoshi's American voice actor portrayed him with a screeching, annoying voice. In Samurai Warriors 2, with Hideyoshi's role in the story expanded, he was assigned a much better actor who was able to convey a great deal of depth and humor, making him much more tolerable. And then when Warriors Orochi hit, they went back to his old voice actor.
Athena Asamiya is the uber-example of Darrining. She's had five seiyuus: Reiko Fukai (KOF '94) to Moe Nagasaki ('95) to Tamao Satou ('96) to Yukina Kurisu ('97) to Haruna Ikezawa ('98). They've seemed to have stuck with Ikezawa since, though.
Robert Garcia is an interesting example. His first voice actor (Eiji Yano in Art of Fighting) was replaced by Kazuhiro Inage for Art of Fighting 2, The King of Fighters '94 and '95. After that, Mantaro Koichi replaced him for Art of Fighting 3 and The King of Fighters '96, and provided Robert's voice for every game up to KOF 2003. Then in Neo Geo Battle Coliseum, Inage returned to voice Robert and has done so ever since.
Overall, however, SNK is a large aversion of this, with most voice cast changes only happening when the company has lost contact with a seiyuu, the seiyuu retires, or (unfortunately) the seiyuu passes away. This means that a vast majority of their characters have been voiced by the same person on at least a semi-regular basis for a good period of time, some even approaching 10 or 20 years of voicework.
Mega Man Volnutt's voice changed between the first and second games; from the then-child actor Corey Seiver in the first to Susan Roman in the second (in other words, they went from averting Crossdressing Voices to playing it straight). Seeing as how both games were recorded in the same studio (and the rest of the cast remained unchanged), it was probably due to Corey reaching puberty between the two.
Mega Man (classic): Ignoring the various cartoons (from both sides of the pacific) based on the franchise, only two games in the series featured voice overs: Mega Man 8 and Mega Man Powered Up, both recorded in two different studios. Thus, Mega Man has been voiced by Ruth Shiraishi in 8 and Cole Howard in Powered Up. Roll was voiced (respectively) by Michelle Gazepis and Angie Beers, Proto Man by Jack Evans then Jonathan Love, Dr. Light by Darryl Stogre and Randall Wiebe, and Dr. Wily by Douglas Kendall and Dean Galloway.
Mega Man X: The series has circulated through three studios, so:
X was voiced by Ruth Shiraishi in Mega Man X4, Peter von Gomm in Mega Man X7 and Mark Gatha from Mega Man X8 to Mega Man: Maverick Hunter X. Additionally, Michael Donovan voiced him in the Ruby-Spears cartoon.
Zero was voiced by Wayne Doster in Mega Man X4, Jack Merluzzi in Mega Man X7 and Lucas Gilbertson from Mega Man X8 to Mega Man: Maverick Hunter X. Additionally, in Marvel vs. Capcom 3, he is voiced by Johnny Yong Bosch.
In Japan, Zero was first voiced by Ryotaro Okiayu in Mega Man X4, but when the first Mega Man Zero was released, he was voiced by Yuuto Kazama. This is a strange case, because Capcom hires either one of these actors depending on which form of Zero is being used (Okiayu for X series Zero and Kazama for Zero as he appears in his own series) and they have always reprised their roles respectively.
Sigma was voiced by Charlie Fontana in Mega Man X4, Walter Roberts in Mega Man X7 and Gerald Matthews in Mega Man: Maverick Hunter X. He was also voiced by Dave Pettitt in Mega Man X8, but it's debatable whether it counts (long story).
Rather irritatingly done within the same game in Heavy Rain for the DLC The Taxidermist, where the character of Madison Paige (the only returning character) quite blatantly has a completely different voice. This was because The Taxidermist had been created as a gameplay demo a couple of years before release, when the final voice actors hadn't been cast. Quantic Dream just decided to save the trouble of recording Madison's lines again with the actress from the main game.
Fans of Quantic Dream's previous games will notice that Madison's voice actress for The Taxidermist is the same as Carla Valenti from Indigo Prophecy.
Although James McCaffrey voiced the character in all three games, in Max Payne series writer Sam Lake modelled for Max in the first game, was replaced by the irreconcilably different-looking Timothy Gibbs in the sequel owing to the project's bigger budget, and then in the third game Max is modeled after his actor. Lampshaded in one of the second game's fourth-wall-breaking dream sequences, when one of Max's doubles looks at himself and says "I've been switched! I didn't use to look like this!"
Max was originally to have a different voice actor in the third game, due to the Time Skip. However, Rockstar Games bowed to fan outcry and cast McCaffrey again; it helps that, with the long period of development, McCaffrey had aged about the same rate Max had between the two games.
In the first Star Trek: Elite Force game, each of the main characters was voiced by their original actor from Star Trek: Voyager except Seven, who was voiced by Joan Buddenhagen. Then when the expansion pack was released, Jeri Ryan stepped in to provide Seven's voice, even going so far as to re-record all of Seven's lines from the original game so there wouldn't be an obvious change when going from original to expansion material.
In Star Trek:DS9: The Fallen, most of the original cast is present to voice their characters, with the rather bizarre exception of Avery Brooks as Captain Sisko. Instead, Sisko is voiced by Kevin Michael Richardson.
One of the changes made for GoldenEye Wii was to replace Pierce Brosnan's James Bond with Daniel Craig. To make the replacement less jarring, all of the other characters in the single player campaign have also had their appearances completely altered as well. They're all new designs (some based on the voice actors), but it does fail a little in terms of polish.
Most of the Electronic Arts-published Bond video games were only able to secure the likenesses of the film characters, but not their voices (the exception being Everything or Nothing, with one of its major selling points being that they managed to get Brosnan, Judi Dench, and John Cleese voicing Bond, M, and Q, respectively; this was notably Brosnan's last time playing the character). After Craig replaced him and Activision acquired the game license, however, it was almost guaranteed that Bond and the other MI6 staff would be voiced by the same people playing them in the films - the only time it wasn't the case was 007 Legends, as Craig was busy actually acting as Bond in a film during its development.
Marty McFly in the newer Back to the Future video game is not voiced by Michael J. Fox (for understandable reasons), but by a voice-acting newcomer named AJ Lo Cascio. The story goes that when AJ first spoke his lines as Marty during a recording session, it was similar enough to Fox that it completely surprised Christopher Lloyd.
Later on however, Michael J. Fox voiced multiple characters in the fifth episode of the game ("OUTATIME") as cameo roles.
Biff Tannen and George McFly have been given new voices in the form of Kid Beyond and Michael X. Sommers (respectively, who also voice Kid Tannen and Arthur McFly), replacing Tom Wilson and Crispin Glover.
Video game versions of Mobile Suit Gundam in America tend to go through Other Darrin moments. Among those were any game that used Heero Yuy (Mark Hildreth, who came to absolutely hate the character due to how he was treated by "fans" during recording of the series) and Domon Kasshu (Mark Gatha, who had, according to Lucas Gilbertson [who voiced Zero in Mega Man X8, Command Mission'', and the first game's remake alongside him as X] had disappeared off the face of the Earth; Wikipedia claims he's living in Newfoundland and Labrador, Canada as an orthopedic surgeon).
Also notably weird in Gundam vs. Zeta Gundam: the original series was dubbed by Ocean Group, while Mobile Suit Zeta Gundam was dubbed by Bluewater, the game uses both groups for their specific storylines, and there's a mission mode that can, if you play your cards right, initiate a What If? mode in which the original series' One-Year War is fought with characters and technology from Zeta. Meaning returning characters will switch voices on the fly, depending on what's happening (Amuro initiating story dialogue in Matthew Erickson's voice, for instance, but then shouting about Char in Brad Swaile's).
In the Broken Sword series the main character George Stobbart's voice is always Rolf Saxon. But Nicole Collard, the second main character in most of them, has been voiced by a different actress in each game: Hazel Ellerby in The Shadow of the Templar (also known as "Circle of Blood"), Jenny Caron Hall in The Smoking Mirror, Sarah Crook in The Sleeping Dragon, Katherine Pageon in The Angel of Death (also known as Secrets of the Ark) and Emma Tate in The Serpent's Curse.
Dead or Alive: Kasumi was first voiced by Sakura Tange. From Dead Or Alive 3 onwards, she is voiced by Houko Kuwashima - although Dead Or Alive Ultimate 2 had the option to choose between Tange and Kuwashima.
Tina also had a different VA in the first game before her current actress Yuko Nagashima took over. Bayman was voiced by Hisao Egawa in the first two games and by Banjo Ginga in all the following ones. Dimensions had numerous replacements, notably seeing Jann Lee, Brad Wong, Raidou, Leon, Bass, and Gen Fu all recast with new voice actors (though in the latter three examples, it's justified as their original voice actors tragically passed away before recording for the new game).
On the English side of things, almost all of the characters returning for Dead or Alive 5 from DOA Dimensionsnote the first mainline DOA entry since DOA 2: Hardcore to be dubbed in English had different voice actors, with the only exceptions being Ryu Hayabusa (Troy Bakernote who also replaced Ninja Gaiden II's voice actor as Hayabusa for NGIII), Hayate (Yuri Lowenthal), Hitomi (Eden Riegel), Tina (Kate Higgins) and Brad Wong (Grant George).
Between Dragon Age: Origins and Dragon Age II, a few characters were recast. Victoria Kruger replaced Mika Simmons as Isabela, because there were concerns about the vocal similarity between Isabela and Queen Anora being too obvious with Isabela in a more major role. Adam Howden replaced Greg Ellis as Anders because Ellis couldn't commit to the recording schedule for such a major character. Merrill was a bit part in the first game voiced by Erin Matthews, and when she became a full party member for Dragon Age II, she was recast with Eve Myles.
In Batman: Arkham City, Tara Strong replaces Arleen Sorkin as the voice of Harley Quinn, David Kaye replaces Tom Kane as Commissioner Gordon, and Grey DeLisle replaces Tasia Valenza as Martha Wayne. The latter two are puzzling, considering Kane and Valenza did return to reprise the respective roles of Quincy Sharp and Poison Ivy.
The tie-in film, Batman: Assault on Arkham sees Hynden Walch as Harley (who first voiced the character on The Batman), replacing both Sorkin and Strong; Neal McDonough replace Chris Cox as Deadshot, despite Cox being present; and Matthew Gray Gubler replace Wally Wingert as the Riddler. Cox himself is the fourth person to voice Commissioner Gordon, and many characters appear, but don't speak, having their grunts done by other people, including John DiMaggio (Killer Shark) filling in for Tatascoire and Blanc as Bane, Jennifer Hale (KillerFrost) filling in for Tasia Valenza as Poison Ivy, and Christian Lanz (who voiced Bird in Arkham Origins) as the Scarecrow.
Batman: Arkham Knight sees John Noble replaces Dino Andrade and Christian Lanz as the Scarecrow. Jonathan Banks is Commissioner Gordon, making the fifth voice actor the present day version of the character has had in the Arkhamversenote in a case of Time-Shifted Actor, Rick D Wasserman voiced a young Gordon in the second Scarecrow hallucination in Asylum. Likewise, Ashley Greene voices Batgirl/Oracle as opposed to Kimberly Brooks or Kelsey Lansdowne, Nightwing is voiced by Scott Porter as opposed to Quinton Flynn or Josh Keaton, and despite Troy Baker coming back as Two-Face and the titular Arkham Knight, Matthew Mercer replaced him as the Tim Drake Robin. However, the main game does see the return of Tara Strong as Harley, Tasia Valenza as Poison Ivy, Wally Wingert as the Riddler, and Mark Hamill as the Joker, and the "Season of Infamy" also sees Steve Blum back as Croc.
Batman Arkham VR sees Tom Austin replace Baker and Mercer as Tim Drake, Hugh Frasier replace Martin Jarvis as Alfred, Ian Redford replace Nolan North as the Penguin, and Jules de Jongh replace Grey DeLisle as Vicki Vale.
The first expansion pack for First Encounter Assault Recon has a brief section where you meet up with Norton Mapes again, who has a different voice actor than he did in the base game. What makes this especially odd is that the other major returning characters (Holiday, Jin, and Fettel) all kept their original voice actors, and the second expansion managed to bring back Commissioner Betters' actor as well (his only lines in Extraction Point were re-used from the original).
Keeping with Extend, the next game, BlazBlue: Chrono Phantasma has reversed almost all of the VA changes (which was due to time constraints causing a rushed localization effort), though the switches for Bang and Hazama look to be permanent for the time being.
In the Italian version of Mass Effect 2, male Sheppard is voiced by Giacomo Zito rather than Claudio Moneta, who voiced him in the first and third games. The fact is actually explained as an extra tidbit in the Italian version of the ending credits: Claudio Moneta was involved in a car accident when he already voiced 4/5 of the game, and rather than replacing him for the last part of the game they just redubbed all his lines from scratch. The dub also replaced Tali, Liara and Udina's voices, but Liara's voice from the first game came back for the third game.
Don Jordan, who played Irving Lambert from Splinter Cell, was inexplicably replaced by Dennis Haysbert for Splinter Cell: Pandora Tomorrow and then inexplicably returned for the rest of the series.
The character Anna Grimsdóttir was in the same boat - first voiced by Claudia Besso, replaced by Adriana Anderson for Pandora Tomorrow, then back to Besso for the rest of the games until Blacklist, where Kate Drummond took the role. Michael Ironside as the player character Sam Fisher was also replaced by Eric Johnson for that game.
Between Rainbow Six: Vegas 1 and 2, every voice actor except for Jung Park's was replacednote Kan Akahashi's actor from Vegas 1 is also credited in Vegas 2, but the character makes no appearances there. Michael Walters is the only other returning character who really sounds anything like he originally did, by way of having the only new actor who bothered retaining the character's distinctive accent - most notably, Logan Keller's Texan accent in the first game disappears entirely in the day or so between its missions and the final one of the second.
An example between mediums came about from the beginning of the series, where John Clark was played by Willem Dafoe in the 1994 film version of Clear and Present Danger, but then for the Rainbow Six games, from the original through Raven Shield and its expansions and console ports, he's voiced by Douglas Rye. For Lockdown he was replaced by Jamieson Price, who was in turn replaced again for his brief speaking-only role in the prologue to Vegas 2.
Also, in the second half of Persona 4: The Animation, Kanji Tatsumi's English lines are done by Matthew Mercer, since Troy Baker was on honeymoon. Baker reprised the role for Golden and Arena, but in the next Personainstallments, Matt was chosen to reprise Kanji instead, as Baker had become a unionized voice actor (Wittenberg did not return to play Teddie for the same reason).
Naoto's VA for 4 and the first Arena game is unknown; it was changed to Mary Elizabeth McGlynn for the anime, and for the second Arena game and Persona Q, it changed again to Valerie Arem.
The very first Persona had a revolving door of actors for the Japanese version, with most of the characters having two to three VAs apiece: one for the game, and two different actors for two different CD dramas. The main protagonist, for example, actually had Akira Ishida (the VA for Persona 3's protagonist) as his VA for the first CD drama, but had two different ones for the second and for the game itself.
Igor, the mysterious proprietor of the Velvet Room, had a reduced presence in the Persona 3 and 4 spinoffs due to the death of his original Japanese VA. His lines in the anime and Arena are recycled, with the Velvet Siblings taking up most of his role instead. They finally got a replacement voice actor, Masane Tsukayama, just in time for Persona 5. This is actually a plot point. Tukayama actually voices Yaldabaoth posing as Igor, and this trope is invoked by the game to draw away suspicion from him. The real Igor still uses recycled lines.
Midway replaced half of the digitized actors from the first two Mortal Kombat games in Mortal Kombat 3. The only ones who returned were Tony Marquez (Kung Lao), Richard Divizio (Kano, Baraka and Kabal), John Parrish (Jax) and Brian Glynn (Shao Kahn).
Eddie Wong replaced Ho Sung Pak as Liu Kang.
Kerri Hoskins replaced Elizabeth Malecki as Sonya Blade.
John Turk replaced Phillip Ahn as Shang Tsung and Daniel Pesina as Sub-Zero. Turk would go on to play all of the masked ninjas in Ultimate Mortal Kombat 3 as well.
In Ultimate, Becky Gable was brought in to replace Katalin Zamiar as the female ninjas (Kitana, Mileena and Jade).
Johnny Cage would be the last character whose actor was replaced. Originally, Midway was planning to leave him out of Mortal Kombat Trilogy due to the Creator Backlash that resulted when Dan Pesina posed in character as Cage for an ad for BloodStorm. But then they decided to bring Cage by replacing Dan Pesina with Chris Alexander.
In the Japanese version of the Pokémon anime, Bianca is voiced by Shizuka Ito; in the trailer for Pokémon Black 2 and White 2, however, she is voiced by Ayana Taketatsu. This also happened in English: Bianca is voiced in the anime by Erica Schroeder (Bella Hudson), but in the trailer by Eileen Stevens. It's most likely because the aforementioned trailer and anime series are created by separate teams.
Same for the Italian version: Anime!Bianca is Benedetta Ponticelli, Trailer!Bianca is Sabrina Bonfitto.
Most of the returning characters from the first Dawn of War got new voice actors in DOWII. This is given an in-story justification for the characters of the Blood Ravens chapter, as one of their geneseed mutations is said to occasionally cause replication errors in the cells of their vocal cords that lead to their voices changing every few years. Eliphas the Inheritor, a member of a completely different Space Marine legion also gets a new VA, but this may be excused by the fact that he's been killed and brought back in a new body.
Beat from Jet Set Radio does not have any of his original voice actors in the Sega Superstars series. Instead, he has a voice that sounds like a 12-year-old boy (even in All-Stars Racing, in which he appears in his Future incarnation, who is older, but yet he still sounds like he's 12!).
On the topic of Sega Superstars/All-Stars, Wreck-It Ralph has a replacement VA in All-Stars Racing Transformed, because it would've cost too much to get John C. Reilly (most game developers not published by EA or Activision can't afford big-name actors). The Pyro, Heavy, and Spy (exclusive to the PC version) sound different too.
Perfect Dark: Joanna Dark's voice actress switched from Eveline Fischer in the original, to Laurence Bouvard in the prequel, also contributing to the loss of her accent (The former actress is British, the latter is American). Daniel Carrington's voice likewise switched from Chris Sutherland in the original to John Kay Steel; conversely to the above, this voice switch contributed to Carrington becoming, as noted on another page, 200% more Scottish than he was originally.
The cast between .hack//Roots and Dot Hack GU shifted. Roots was dubbed in Canada by The Ocean Group, while GU's voice work was done in America (Bang Zoom!).
In the first Call of Duty: Black Ops, Jason Hudson was played by Ed Harris. However, for Call of Duty: Black Ops II, he was replaced by Michael Keaton. Doesn't sound too bad on paper, but Keaton's voice is considerably less deep and gravelly than Harris's, and since the character was supposed to be 20 years older in the second game, the transition is quite rough.
Black Ops has a single-game example with John F. Kennedy - in the singleplayer mission "U.S.D.D." he is voiced by Chriss Anglin, who attempts to realistically mimic JFK's voice, while in the Zombies level "Five" he's voiced by Jim Meskimen, who goes the So Bad, It's Good route of the stereotypical, comedic exaggeration of JFK's voice.
Modern Warfare 3 replaced the actors for Overlord and MacMillan, though that can be justified (someone new could have taken over as "Overlord Actual" between the two games, and MacMillan is twenty years older than he was when we last saw him). Less justifiably, Nikolai's actor has also been replaced, complete with his final line from MW2 being redubbed with the new actor in the intro to MW3.
In Dark Seed Mike Dawson is portrayed by the creator of the same name, Mike Dawson. In the sequel, Mike is portrayed by Chris Gilbert and apart from the wardrobe, there's almost no similarity between the two.
007: From Russia with Love recast almost the entire film, due largely to the fact that the game was made forty-odd years later and, for example, Bernard Lee (M) died in 1981. However, the game traded itself in part on the fact that Sean Connery was convinced to voice James Bond, reprising the role for the first time since Never Say Never Again.
Borderlands 2 replaced the voice actors for both Roland and Mordecai. Roland went from sounding less like Unreal Tournament III's version of Malcolm (complete with gangsta-isms) who took everything not very seriously, to a very straight-faced leader-sounding sort of person. Mordecai was given an accent and a bit of a slur.
Star Trek Online has Cryptic going out of its way to try to obtain many of the original actors should a famed character be used in some way. So far, the only exception to this is the Guardian of Forver, who was voiced by the late James Doohan (TOS' Scotty). Whoever his new voice actor is, he's really Narmy.
In 2015, it was revealed that Cryptic went SAG-certified and that the limited number of spaces for non-SAG members should be dedicated to other Star Trek alumni. This caused a number of voice actors, such as Gabriel Wolf (who voiced the Liberated Borg Gaius Selan) to be jettisoned out. The first person known to be replaced was Chancellor J'mpok, originally voiced by Jon St. John and now voiced by Liam McIntyre.
In Team Fortress 2 the Engineer is ordinarily voiced by Grant Goodeve, but when he was occupied Nolan North took over for the "Expiration Date" short. Likewise, the Soldier's voice actor Rick May came down with throat cancer and North had to do his trademark scream.
The cast of Hatoful Boyfriend is entirely birds, played by single still images of said birds, sometimes with clothes or blood drawn over top. Their creator refers to the birds photographed as their 'actors' and meticulously credits sources and requests the use of their images for each game and project. When Anghel's source didn't respond she brought in a new 'actor', likewise with Ryouta.
DuckTales Remastered is well known for Way Forward being able to recruit virtually every possible voice actor from the old cartoon, even Alan Young (who was 94 at the time) and June Foray (who was 95). However, three actors had already passed on prior to this - Joan Gerber, Hal Smith, and Hamilton Camp, the voices of Mrs. Beakley, Gyro Gearloose, Flintheart Glomgold, and Fenton Crackshell/Gizmoduck. For this, Wendee Lee, Chris Edgerly, Brian George and Eric Bauza took up their roles respectively.
Several of the characters were not able to get their original actors to play them. For the most part, the replacement voice actors give very good and uncanny performances emulating the voices of the characters. However, some of them manage to sound a little off. The voice actors for Sulley, Captain Jack Sparrow and Ralph are some of the biggest offenders.
Courtnee Draper replaces Caitlyn Taylor Love as White Tiger.
Despite voicing the Green Goblin before, Nolan North is this to Steven Weber as the Green Goblin, given the Goblin North voiced by was the classic Goblin and again, the Spider-Man playset in based on the Ultimate Spider-Man cartoon.
Subverted by the other Guest Fighter, Akatsuki from Akatsuki Blitzkampf: the trope seems to be played straight since the credits for Blitzkampf cite "Shouji Hijikata" as his seiyuu and UNIB lists Shinobu Matsumoto instead... but it looks like "Shouji Hijikata" is the aforementioned Shinobu Matsumoto, only now using his birth name rather than a pseudonym.
The video game Donald Duck: Goin' Qu@ckers is notable for featuring Gyro Gearloose and Gladstone Gander as supporting characters as well as Merlock from DuckTales the Movie: Treasure of the Lost Lamp as the Big Bad, but Hal Smith, Rob Paulsen, and Christopher Lloyd did not get to reprise any of the characters (Hal Smith because he died long before the game was developed and the other two because they apparently weren't available). As a result, all three characters are instead played by Corey Burton.
Transformers: Devastation: While a number of the voice actors from the original cartoon perform Role Reprisals, several characters have been recast due to unfortunate deaths, such as Wheeljack and Starscream (both originally voiced by Chris Latta) being played by Christopher Swindle and Scott Whyte. However, some still-living actors are absent (Corey Burton doesn't voice Shockwave), and in an odd example of the trope, roles originally played by returning cast members are now played by others (in the cartoon, Megatron, Soundwave, Rumble, Skywarp and Mixmaster were all played by Frank Welker, but other actors play those last three while Frank revoices the first two).
Altaïr from Assassin's Creed has a completely different voice and ACCENT between his appearances in the first game and Revelations, with a short repeated dialogue re-dubbed with the new actor. The change in accent could however be explained that in the first game it was being viewed with Abstergo's Animus, while in Revelations it's being viewed with the Assassins' Animus viewing Ezio viewing one of the Memory Seals, so it's possible the different Animi have different translation software.
Unlike the other actors from the original Alien, including Sigourney Weaver, Ian Holm didn't return for Alien: Isolation, so he's replaced by Dave B. Mitchell. The only other exception is John Hurt as Kane but then again, the content relating to the original film takes place after his character's death.
Somewhat present in the Saints Row series. Due to the character creator, players can choose from multiple different voices, which are made to fit different nationalities. The problem is that the nationalities change in almost every game. This is a problem because the Player character is always the same one, meaning that the characters nationality might change from game to game.
In addition, sometimes the actor/actress used for the voice changes too. For example, the American male voice is portrayed by a different person in SR2 and SR3.
Multiple characters in Webkinz have had their voices changed repeatedly, most notably Ms. Birdy. While her original voice was almost grandmother-like, her new voice is higher-pitched and sounds younger. Tabby von Meow's voice was also changed in 2011.
Harry Flynn got another voice for the Uncharted 4 multiplayer. Valentine claims that he wasn't even contacted, while ND claims that they couldn't come to an agreement to get him to return.
O'Brien also provided Aku Aku's voice when he appears and disappears during gameplay in all of the games where he appears as an item. In the cutscenes of Crash Bandicoot 3: Warped he's voiced by Mel Winkler up until Crash of the Titans, where he's now voiced by Greg Eagles.
Papu Papu's grunts in the first game were provided by David Siller. Michael Gollom voiced him in Crash Team Racing, then Dwight Schultz in Twinsanity.
Uka Uka was voiced by Clancy Brown in his first appearances, up until Twinsanity where he's voiced by Alex Fernandez. In Crash of the Titans, he's given a completely new design and to go with it is voiced by John DiMaggio. Fernandez returns to the role in Skylanders Imaginators, where Uka Uka goes back to his Twinsanity design.
Dingodile was voiced by William Hootkins in Warped, then by Chip Chinery in Crash Team Racing and Dwight Schultz in Crash Nitro Kart and Twinsanity.
Fake Crash was voiced by Michael Connor in Warped and Crash Team Racing, then by Dwight Schultz in Crash Nitro Kart.
N. Oxide was voiced by David Anthony Pizzuto in Crash Team Racing, then by Quinton Flynn in Crash Nitro Kart.
Crunch was voiced by Kevin Michael Richardson in The Wrath of Cortex and Crash Nitro Kart, then by Chris Williams in subsequent appearances.
Nina Cortex was originally The Voiceless, but her grunts in Twinsanity were provided by Susan Silo. In Crash Tag Team Racing and beyond she's voiced by Amy Gross, but is voiced by Debi Derryberry in the Nintendo DS version of Crash of the Titans.
The Spider-Man Trilogy would see Tobey Maguire reprise his role as Spider-Man and the actors who played villains reprise their roles — in stuff they were villains in, as before the Spider-Man 3 game, future Spidey voice actor Josh Keaton filled in for James Franco as Harry Osborn and likewise, J. K. Simmons would only reprise his role as Jonah in that game, being voiced in the earlier games by Jay Gordon. Additionally, Kirsten Dunst would only reprise her role as Mary Jane in Spider-Man 2, being voiced in Spider-Man: The Movie and the third game by a different actress (including Kari Wahlgren in the third one) and Robbie, Betty Brant, Aunt May, Curt Connors, and Mendell Stromm being voiced by different voice actors period. Even within the game series, Kraven, the Scorpion, the Rhino, and the aforementioned Dr. Connors would change voice actors.
When the game first started, Arleen Sorkin had reprised her role as Harley Quinn. However, when creating new content, Arleen wasn't doing the voice anymore. Instead, they went for Jen Brown (Pyrrha Nikos of RWBY, Agent Carolina of Red vs. Blue)Red vs. Blue)