However, after the Pistols for Pandas PSA, Crack Stuntman gets his job back as Gunhaver's VA, averting this trope.
Several voice changes have occurred on Happy Tree Friends as cast members left, most of the departures having come for various reasons in 2005:
Ellen Connell replaced Dana Belben as Cub, Giggles and Petunia. After Connell's last role in "Wrath of Con", she was replaced by Lori Jee in all three roles. Although rumors had surfaced about Ellen dying in a horrible accident, Warren Graff confirmed she "moved to L.A., which is like death".
Initially, Kenn Navarro voiced only Cuddles. After Mike Giambruno (who voiced both Lifty and Shifty) left the show, Navarro took over those roles. Navarro also voiced Handy in "A Hole Lotta Love" because Warren Graff was not available.
One episode even features both Navarro's and Giambruno's voices for Lifty and Shifty.
Aubrey Ankrum (Pop and Flippy) left the show at some unknown point. His voice has been sampled for Pop and Flippy's evil side, although Navarro has taken over voicing the latter's good side.
Francis Carr replaced Jeff Biancalana as Russell.
David Winn replaced Rhode Montijo, who voiced Lumpy and Splendid.
Parodied in The Order of the Stick: when an episodic vampire dwarf appears on the airship the characters are travelling by, Vaarsivus' talking bird familiar wonders for a moment if that's vampire Durkon who has been recast.
Eddsworld had Edd going from Edd Gould to Tim Hautekeit. This is justified, due to Gould dying of leukemia.
From Volume 3 onwards, Lie Ren is being voiced by Neath Oum, brother of the late Monty Oum, taking his brother's role as the character.
Due to J.J. Castillo leaving Rooster Teeth before the start of Volume 3, he was replaced as Mercury Black's VA by Yuri Lowenthal.
In Taco-Man: The Game Master, Princess Polygon's voice actor changed from Sam T Nelson to Rina-Chan, in either the second or the third episode. In the fifth episode, Taco-Man actually comments to Princess Polygon that her voice sounds much nicer compared to when they first met. She relapses into her original voice when she thanks him, then clears her throat and thanks him in her newer voice.