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Fifth Doctor: I'm the Doctor, who are you? Tenth Doctor: Yes, you are! You are the Doctor! Fifth Doctor: Yes I am, I'm the Doctor. Tenth Doctor: Ohh, good for you, Doctor! Good for brilliant ol' you! Fifth Doctor: Is there something wrong with you?
Some element of a show's Applied Phlebotinum causes a character's appearance and voice to change completely. On Speculative Fiction shows, this can be almost anything. On real-world shows, this is almost always Magic Plastic Surgery - which, on TV, works much better than it does in reality.
This is a catch-all for the recasting of a character using an in-continuity explanation. It takes its name from Doctor Who, whose titular Doctor is an alien capable of "regenerating" into a new form whenever the lead role needs re-casting.
Compare to: Jonas Quinn (which introduces a totally new character much like the old one), and The Other Darrin, aka Sister Becky (where the actor is replaced without explanation).
Examples:
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