Both authors of Luz Clawthorne have imagined who'd be the best choices to voice their OCs: at first they were suggested by fans, but the authors quickly decided it was better to give their official selections. All choices (original and finalized) can be seen below along with the reasons they were selected, ranging from All-Star Cast to The Other Darrin to even Role Reprise. Notably, most of them are alumni of Disney shows in addition to The Owl House.
- Dee Bradley Baker, who plays Eda as the Owl Beast, voices Barcus, Luz's sentient bat Brucynote (as of Chapter 21), and Beel Zatar.
- Blayne Weaver, the voice of Peter Pan since Return To Never Land, voices Puck Goodfellownote .
- Keston John, who voices Darius as well as Hordak, Horde Prime, and the Horde clones, voices Puck as the old witch.
- Oscar Isaac, portrayer of Moon Knight in his epynonomous series, voices Anu Bist.note
- Diamond White, who voices Fuli in The Lion Guard, Holly for Phineas and Ferb, and Lunella Lafayette on Moon Girl and Devil Dinosaur, replaces Grey Delisle as Catnote .
- Bumper Robinson, who voices Principal Bump, replaces Matt Chapman as Gilbert Park (LC's version of Harvey Park) due to their identical voicesnote .
- Justin Rupple, who replaced T.J. Miller as the voice of Tuffnutt Thorston in How to Train Your Dragon: The Hidden World, replaces Miller again as Robbie Valentino due to Miller's Role-Ending Misdemeanor in 2018note .
- Ben Diskin voices Levi Thians and Tres.
- Alfred Molina, who voiced the Multi-Bear in Gravity Falls and is best known as Doctor Octopus in Spider-Man 2, voices Vanz Ator.
- Nika Futterman, who voiced Zira in The Lion Guard, first voices Bangles and later plays Kadabe.
- Charlie Schlatter, known as Kick Buttowski but better identified as The Flash and Kevin Levin, voices Beocrow and Zepher.
- Ming-Na Wen, iconic for voicing Mulan, voices Kitsuni.
- Johnny Yong Bosch voices Simon Saltstar.
- Grey Delisle, portrayer of Katya, Masha, Jackie Lynn Thomas and other minor characters, voices Boscha's mother Nicole Hieronnote , and Eve Slipknotnote .
- Misty Lee, who voices Priscilla "The Killa" Paddock in Amphibia, voices Boscha's other mother Athena Hieron and Iggy.
- Amy Sedaris, who voiced Mina Loveberry in Star vs. the Forces of Evil and Foxy Loxy in Chicken Little, voices Dr. Bridenote .
- Kari Wahlgren, voice actress of Amber and Shandra Jimenez, voices multiple characters, such as Dolly Tempus, Amelia's mother Mary Regal, Felicity Foxnote , and Tina Ryo.
- Toks Olagundoye, known as Mrs. Beakley in DuckTales (2017), voices Ms. Travelernote .
- Leslie Rodriguez Kritzer voices Ms. Traveler as Rosie from Hazbin Hotel.
- Jason Mantzoukas replaces Matt Chapman as Horace, the thin Hexside student with the bowl-cut.
- Alex Hirsch, voice of King, Hooty, Steve (Season 1), Stan Pines, Soos Ramirez, and several other characters in both The Owl House and Gravity Falls, portrays Larry the coven guard.
- Dana Davis, who voices Kelly in Star Vs., Ally in Amphibia, and Lonnie in She-Ra and the Princesses of Power, replaces Eden Riegel as Mary, or Lambi as she's known in LC.
- Phil Lamarr voices Skara's father, Slasher Brooke and teen villain Steam Punk.
- Kimberly Brooks, who voices Skara and provides the vocal effects for Eileen, voices the former's mother Calypso Brooke, Cyndi the right head of the Cerberus sisters, Maya, and Raven/Light Caster.
- As a matter of fact, all the Cerberus sisters share their voices with the Hex Girls, Cyndi sharing her voice with Luna: Jennifer Hale, who plays Thorn, voices the left head Patti, and Jane Wiedlin, who voices Dusk, voices Blondie, the middle head.
- Jack McBrayer, known as Wander in Wander over Yonder, Irving DuBois in Phineas and Ferb, and Fix-It Felix Jr. in Wreck-It Ralph, voices Amelia's father, Harlan Regal.note
- Khary Payton, who voices Cyborg in most DC media and Rafiki in The Lion Guard, voices Cat's father Zebra Harwitch and her older brother Dog.
- Cree Summer, who voiced Dr. Frakes in Amphibia and is best known as Suzie Carmichael in Rugrats, voices Cat's mother Swan Harwitch, Skara's little sister Scabrina note , and Headmistress Midday, the principal of St. Epiderm.
- Cory Doran, who voiced Mike and his multiple personalities in Total Drama, voices Cat's little brother Moose Harwitch.
- Samuel Ramey voices the Inner Demon, an expy of The Beast.
- Freddie Prinze Jr. voices Linkin Days, a counterpart of Fred Jones who Prinze portrayed in the live action Scooby-Doo movies, thus doubling as Actor Allusion.
- Kate Micucci, voice of Velma Dinkley since 2015, Terri in Amphibia, Webby Vanderquack in Duck Tales (2017) and Julie Kane in Motorcity, voices Sioux Bansheeles, a counterpart of Velma Dinkley, which doubles as Actor Allusion.
- Matthew Lillard voices Korn Fleabite, a counterpart of Shaggy Rogers which doubles as Actor Allusion.
- Tress MacNeille, who voiced the Fates in Hercules: The Animated Series, voices the Weird Sisters who later turn out to be an alter-ego of the Fates.
- Seth Macfarlane voices Odalia's brother, Geist Grunhar-Blightnote .
- Jess Harnell, best known as Wakko Warner and Crash Bandicoot along with Texas in Motorcity, voices Rockynote .
- Keith David, voice of King Andrias in Amphibia, Dr. Facilier in The Princess and the Frog, Glossaryck in Star Vs., and Husk in Hazbin Hotel, plays Baron Samedi.
- Cissy Jones, who portrays Lilith, voices Baron Samedi while possessing Lilith.
- Mark Hamill, voice of the Joker in various DC media and Fire Lord Ozai, voices Lord Oberon.note
- Rhys Darby voices Arthur Blight.note
- Ashley Jensen, who voices Downy McDuck in DuckTales (2017) voices Destiny Blight. note
- Jason Marsden, a veteran of several roles with Max Goofnote being one of the best known, voices Boscha's older brother Boris.
- Kimiko Glenn, known as Lena in DuckTales (2017), voices Felicia Fox.
- Christopher McCulloch, voice of Hank Venture in The Venture Bros., voices Abel Reisender.
- Eden Espinosa, known as Cassandra in Tangled: The Series, voices Emily Tricks.
- Janice Kawaye voices Stella Northstar.
- AJ Michalka, who voiced Catra in She-Ra and portrays Lainey Lewis in The Goldbergs and Schooled, voices Nina Fangs, doubling as an Actor Allusion to Catra.
- AJ's sister Aly, whose only Disney role was Keely Teslow in Phil of the Future, voices Nina's older sister Cally.
- J.B. Smoove, who voices Anton Zeck/Bebop in Teenage Mutant Ninja Turtles (2012), voices Tito Jackwitch who's also based off of Michael Jackson.
- Fred Tatasciore, who voiced Malphas, voices Cain Saltstar.
- Eric Bauza, who voiced Willow's father Gilbert and Principal Faust, voices Goregon, Foxy Loxy, and Honest John.
- Alan Tudyk, voice of River Butterfly and Ludo in Star Vs., voices Weaselton, an expy of Duke Weaselton.
- Rob Paulsen, voice of Gustav/Charlie Booth, impersonates Gilbert Gottfried as he did as Nicolai Technus to succeed Gottfried as Iago due to his death in 2022.
- Kate Mulgrew provides the voice of Ghost.
- Steve Blum voices Principal McScreamnote , and the Grim Goblin.
- With the exception of McScream, all Total Drama expies are voiced by their basis' voice actors.
- Clé Bennett, who voiced Chef Hatchet and DJ, voices Mr. Cooker and Clé Ironwood.
- Sunday Muse, who voices Ella, voices Sunny Muse.
- Kristi Friday, who voices Scarlett, voices Ruby Friday.
- Rachel Wilson, who voiced Heather, voices Venoma Heathens.
- Marco Grazzini, the original voice of Alejandro, voices Alburno Striker.
- Peter Oldring, who voiced Ezekiel and Cody, voices Zebiel and Hugh.
- Emilie-Claire Barlow, who voices Courtney, voices Le'Belle Case.
- Brian Froud, who voices Harold, voices Napoli McGrady III.
- Katie Bergin, who voices Jasmine, voices Bindell Crocslayer.
- Scott McCord, voice of Owen and Trent, voices Bowen and Grip.
- Carter Hayden, voice of Noah, voices Carter.
- Kevin Duhaney, the voice of Cameron, voices Scarmeron.
- Tyrone Savage, voice of Lightning, voices Thunder.
- Laurie Elliott, voice of Jo, voices Joana.
- James Wallis, voice of Scott, voices Skrap.
- Caitlynne Medrek, who voiced Dawn, voices Hikari.
- Megan Fahlenbock, voice of Gwen, voices Meg.
- Dan Petronijevic, the voice of Geoff, voices Dale the Party Dog.
- Stacey DePass and Stephanie Anne Mills, who voice Emma and Kitty in The Ridonculous Race, voice werecats Jemma and Lynxa Milk.
- Barbara Mamabolo, the voice of Zoey, plays Barbara Marlo.
- Jon Cor, voice of Brick, portrays Dogma Taggs.
- Julia Chantrey, who played Eva, voices Chantley.
- Judd Nelson, who voices Duncan, voices Judd the ex-coven scout.
- Larry Brantley, known as Spinner in My Hero Academia, voices Seth of Septaris.
- Danica McKellar voices Megan/Basilisk #1note .
- Lauren Synger, who voiced Alice Angel, Twisted Alice, and Allison Angel in Bendy and the Ink Machine and its sequel, voices Angel Sinclair.
- Ashley Johnson, who voices Terra in Teen Titans and Gwen Tennyson for most of the original Ben 10 continuity, voices Angel in her youth.
- Zelda Williams, known as Kuvira in The Legend of Korra and for her roles in the TMNT franchise, voices Abigail Gates.
- David Faustino, voice of Mako in The Legend of Korra and Dagur the Deranged in the Dreamworks Dragons series, voices Joseph Gates.
- Clancy Brown voices Isaac Gates, Shere Khan, and Krampus in "Krampmus Shenanigans", where he also reprises his role as Santa Claus from Phineas and Ferb.
- Frank Welker voices Scooter Crane, Edgar, and Bobby Bones/Bonejaws.
- Kevin Michael Richardson, who voiced Patch and Tarak in The Owl House, Sheriff Blubs and the Lumberjack Ghost in Gravity Falls, Rhombulous in Star Vs., and Mr. Flour in Amphibia, voices Samwitch Saltstar.
- Colleen Oshaughnessey, best known as Tails in Sonic the Hedgehog and Ino Yamanaka in Naruto, voices Mai, a female expy of Tails.
- Jane Kaczmarek succeeds Jessica Walter as Ms. Heinous/Meteora Butterfly, due to her death in 2021.
- Aimee Carrero voices Donna Masterskull, an expy of Adora (doubling as Actor Allusion).
- Meagan Smith, the original voice of Gwen Tennyson, voices Veronica Rex.
- Ogie Banks, who voiced Power Man and Miles Morales in Ultimate Spider-Man, voices Tyrone Ironwood.
- Antony Del Rio, best known as Ekko, voices Kyle (yes, a complete transplant of that Kyle)note and Nate/Live-Ammo.
- Sharon Stone voices Persephone.
- Sean Schemmel voices Sun Wukong the Monkey King. note
- Ian Roberts voices Terry Greasenote .
- Lauren Tom, who voiced Susan Long in American Dragon: Jake Long, voices Yuki Ito.
- Rosario Dawson and Yvette Nicole Brown respectively voice Donna's mothers, Diana and Gladys Masterskull.
- Ron Perlman, best known as Slade and The Lich, voices the Horned King.
- Christina Ricci voices Clara Gatesnote .
- Lacey Chabert, voice of Gwen Stacy in The Spectacular Spider-Man, acts as the voice of Dana Underwood.
- Logan Miller, who portrays Tripp Campbell in I'm in the Band and voices Nova in Ultimate Spider-Man, voices Gus Gordon.
- Miller also voices Vee when she briefly impersonated Gus in Chapter 97: "Those Gravity Falls Kids".
- Beth Littleford, who played Tripp's mom Beth in IITB, voices Gus G's mother Nora.
- Wayne Knight, who voiced Al in Toy Story 2, voices Fazio.
- Max Mittelman portrays Danny Dilburnnote .
- August Forman, who voiced the piercings teen who appeared in "Thanks to Them", voices Riley Strange.
- Anna Akana, who voices Sasha Waybright in Amphibia, voices Roxy Armstrongnote .
- Emily Jenness, known as Dawn in Pokémon: The Series and Zuzu Boyle and her counterparts in Yu-Gi-Oh! ARC-V, voices Sarah Atos.
- Zeno Robinson, who voices Hunter, Derwin, Rudo, and Young King Andrias in Amphibia, voices Andrew Rollersnote .
- Kate Higgins, known for playing Sakura Haruno and iconic for Tails, voices Minerva Witchmore and Clair Drakescale.
- Stephanie Sheh, famous for her Shrinking Violet roles such as Hinata Hyuga, voices Lindsay Shystream.
- Billy West voices Peter Bloomhog, which is a nod to the last time West voiced a Andy Warhol expy.
- Tru Valentino and Frank Tadaro respectively do the voices of Cups and Mugsnote .
- Josh Keaton, who voiced teenage Hercules and Peter Parker/Spider-Man from 2008 to 2012, voices Teri Oscorne, an expy of Harry Osborn who Keaton also voiced in a few Spider-Man video games.note .
- Alan Rachins, who voiced Norman Osborn in The Spectacular Spider-Man voices Gibson Oscorne, an expy of Norman.
- Yuri Lowenthal, best known as Sasuke Uchiha and teenage Ben Tennyson, voices Adam Blightnote and Conner/Andros.
- Jessica Dicicco, who voiced Danika Hunnicut in American Dragon: Jake Long, voices another character from said series: Rose's twin sister Violetnote .
- Karen Fukuhara, who voices Glimmer, voices Acorn.
- Reid Scott, who voiced Mike Chilton in Motorcity, voices Cross Drakescale.
- As of Chapter 88, John Cusack replaces Justin Roiland as Witch Morty Smith following Roiland's being charged with domestic abuse.
- Some of the expies within Mel's gang are voiced by whoever portrayed the Descendants characters they portrayed;
- Dove Cameron, who portrayed Mal, plays Mel/Melonie.
- Sofia Carson, who portrayed Evie, voices Trini.
- Booboo Stewart, who portrayed Jay, voiced D-Josh.
- Michael Cimino, who voices Kevin Grant-Gomez in Hamster & Gretel and Eduardo in Moon Girl and Devil Dinosaur, replaces the late Cameron Boyce as Blazer, the expy of Carlos.
- Tony Daniels, the second voice actor who played Gambit in X-Men: The Animated Series, voices Jackson Hearts.
- Vella Lovell, voice of Mermista from She-Ra and Jordan Fisher, voice of Sea Hawk, play Serpentina and Eustace Curry.
- Daran Norris and Susanne Blakeslee (who voices Maleficent and Grimhilde the Evil Queen) voice Leo and Pam Fangs.
- Caitlyn Taylor Love, who played Izzy Fuentes in I'm in the Band and voiced White Tiger in Ultimate Spider-Man, voices Zee Drakescale.
- Troy Baker, who voices Captain Grime in Amphibia and Batman in DC media, voices Damien Drakescale. Yuri Lowenthal voices Damien in his youth.
- Laurence Fishburne, who played Morpheus in The Matrix and the Beyonder in Moon Girl, replaces Jonathan Katz as Morpheus from Hercules: The Animated Series.
- Dante Basco, voice of Jake Long, voices Roughhouse/"Ruff" the Lost Boynote .
- Mike Pollock, iconic for playing Dr. Eggman in the Sonic franchise, voices Drayden Drakescalenote .
- Lauren Ash voices Banjo Scorpincher, an expy of Scorpia from She-Ra.
- Patrick Warburton voices Patrick note , Terra's aide.
- Tim Simons and Sam Richardson voice Aoi and Aka, expies of Huginn and Muninn.
- Rosie Perez, who voices Chel, voices Ixchel.