- Wicked: Elphaba (standby for Idina Menzel)
- Brooklyn: Brooklyn (2003 on New Denver Civic Theater, 2004 on Broadway)
- RENT: Maureen Johnson (succeeding Idina Menzel)
Tropes associated with her roles include:
- Ink-Suit Actor: Orizaba and Cassandra.
- Star-Making Role: Elphaba, which was also her Broadway debut.
- Those Two Actors: With Idina Menzel, although played with in that they haven't played any roles with each other. Instead, Espinosa has succeeded Menzel in some Broadway productions, namely as Elphaba, as well as Maureen Johnson.