- Debut: "Holy Crap"
- Abusive Parents: He's a total jerk to Peter but there's a reason-Peter's not his biological son, since Thelma cheated on him with an Irish drunk. Even so, as Brian points out, the fact that he still raised Peter as if he was his own son did show that he loved him, despite everything.
- The Fundamentalist: Francis is an extremely religious Catholic. However, he was extremely stubborn with his views. When the Pope was fine with Peter's interfaith marriage to Lois and tries to convince Francis to accept Peter's marriage, Francis deems the Pope to have gotten soft.
- Grumpy Old Man: Rather old and an extremely grumpy Jerkass.
- Hate Sink: Not as bad as other characters in this show, but still obnoxious enough to qualify.
- I Am Not Your Father: It was revealed that Francis was not Peter's biological father, but an Irishman named Mickey McFinnigan. A series of memories show Francis constantly told Peter this.
- Jerkass: Part of why he was killed off as the writers kept finding it harder to write for him for this reason.
- Jerk with a Heart of Gold: As revealed in an early episode he loves Peter, he just doesn't like him (especially after he married a woman who was Protestant and later, revealed to be Jewish).
- Killed Off for Real: On "Peter's Two Dads" where a drunken Peter falls on him while riding a unicycle, mortally injuring him. He suffered crushed ribs, busted spleen and a punctured lung. Charles Durning's ill health (and subsequent passing) also played a role in the decision not to have Francis appear any longer.
- Obnoxious In-Laws: He doesn't like that Peter has married a woman who was Protestant ( and, later, revealed to be Jewish).
- Pet the Dog: As much of an asshole as he is, he does have these in each major appearance:
- Telling Peter he loves him and hugging him in "Holy Crap".
- Teaming up with Brian to snap Peter out of his delusions in "The Father, the Son, and the Holy Fonz".
- Encouraging Peter (as a ghost, no less) to use being a "fat, stinking drunk" to prove to Mickey McFinnigan that he's his son in "Peter's Two Dads".
- Debut: "Peter, Peter, Caviar Eater"
Lois's wealthy mother. Voiced by Alex Borstein.
- Dark and Troubled Past: She's a survivor of the Holocaust.
- Depending on the Writer: Her feelings about Peter. Either she hates him like her husband does or likes him and is amused by his antics. For the most part, she seems to be indifferent towards him. However, she was willing to sleep with him to save his marriage to Lois.
- Fan Disservice: Her magazine shoot in "Fresh Heir".
- Gold Digger: Depending on the Writer, she is either a woman who married into money, or genuinely Happily Married to Carter. Her backstory with Carter indicates the latter.
- Hypocrite: In "Welcome Back Carter," she was outraged to learn about her husband cheating on her, and kicked him out. However, she had jumped at the chance to sleep with Peter in "Bill And Peter's Bogus Journey," just to spite Carter. And this isn't even mentioning the three other men she's had affairs with in the past (including Jackie Gleeson, which traumatized her son).
- Out of Focus: Compared to her husband, she has very little screentime.
- Satellite Character: Much of the time when she does, it usually has something do with Carter or Lois
- Debut: "Emission Impossible"
Lois's younger sister. Voiced by Carol Kane in "Emission Impossible" and by Julie Hagerty for the rest of the series.
- Ascended Extra: Before Season 9, she only had one appearance in "Emission Impossible" and a cameo in "The Fat Guy Strangler". Ever since she got married to Adam West, she had more regular appearances.
- Chuck Cunningham Syndrome: Not her, but her infant son born in "Emission Impossible" is not seen in the other episodes where his mother appears on screen. He has never been mentioned at all but could be living with his biological father.
- Fourth Date Marriage: Really. She marries Adam not long after getting divorced and meeting him.
- Happily Married: With the Mayor West since "Brothers & Sisters".
- Nice Girl: From what we see of her. If not for her self-esteem issues, it's clear she's a rather nice person overall.
- Overly Long Name: Carol (née Pewterschmidt, previously Johnson, Carrington, Stone, O'Craggity, Canseco, Shteinholtz, Washington, Proudfoot and Fong).
- Palette Swap: She is practically a copy of Lois, the only difference being the clothing and the hair.
- Serial Spouse: Married for nine times before meeting Adam West.
- Debut: "E. Peterbus Unum"
Brian's gay cousin. Like him, he's also an anthropomorphic dog. Voiced by Seth MacFarlane.
- Camp Gay: Doesn't even begin to describe him.
- Chuck Cunningham Syndrome: Disappeared after the gay marriage episode, due to him not being well-received.
- Early-Bird Cameo: On the episode, "E. Peterbus Unum," Jasper first appeared in a cutaway of Peter bringing home something the family doesn't really need: a second dog (one who was basically a Camp Gay Brian who asks for Cheese Doodles and honks a clown horn). Jasper was also seen near the end of "The Thin White Line" working at Club Med when Brian tells the family that he's leaving for California and will be living with his cousin.
- The Bus Came Back: Reappears in "Life Of Brian" and season 11's "Brian's Play", albeit in very short scenes.
- Voiced by: Tony SiricoDebut: "Life Of Brian"
A Wiseguy (well, Wisedog) with an Italian accent, and a streetwise attitude. Purchased at the pet store by the Griffins after Brian's now undone death. Voiced by Tony Sirico.
- American Accents: He speaks with something of a New-York dialect.
- Big Ol' Eyebrows: Compared to other characters.
- The Cameo: He makes a brief appearance at the end of "The Boys in the Band", having replaced Brian in the band "Red Shirt, Blue Shirt."
- Foil: To Brian. Though they're both talking dogs, Brian is an atheist (pseudo-)intellectual with strong left-wing views, while Vinnie is religious, a bit of a musclehead, and doesn't try to hide his prejudices against homosexuals and other minorities. Despite this, most fanfics and fanart portray the two as getting along well. Whether they actually could remains to be seen, however.
- Gratuitous Italian: He refers to Stewie by a pseudo-Italian version of his name. Stewie immediately tells him that it doesn't remotely sound like an Italian variant of his name.
- Heroic Sacrifice: He doesn't die, but he helped Stewie go back in time to save Brian's life, knowing fully well that this would result in him never being adopted by Peter.
- Jerk with a Heart of Gold: He acts tough, beats up people for acting different, and tends to insult people on occasions, but he does really care for others as he tried to help Stewie get over Brian's death and also let Stewie go back to the past and save Brian's life, even though it meant he would never meet The Griffins. Despite his Italian mafia vive, he can actually be a really Nice Guy.
- The Lost Lenore: Subverted - though he seems to have been upset by the death of his previous owner (Leo), he seems to have moved on. He is quickly able to understand that the Griffins are going through similar grief, and does his best to be their new companions.
- Mix-and-Match Critter: Is 1/16th cat, or, as he calls himself, a "Pussyhound".
- Nice Guy: Despite his mafia connections, he actually does care deeply for the Griffins who took him in, especially Stewie. When Stewie told him that when he saves Brian's life, he would probably never see him again. Vinny acts very selflessly and even though he has loved his time with the Griffins, he is wiling to give up that experience for their renewed happiness.
- Pet the Dog: Comforting Stewie following Brian's (now undone) death.
- Politically Incorrect Hero: Just ask poor "Johnny Chickstuff".
- Promoted to Opening Titles: Although he didn't last long enough to enjoy it.
- Replacement Goldfish: Stewie doesn't take this fact very well.
- Replacement Scrappy: For Stewie, but he earns his friendship by helping him cope with Brian's death.
- Ret Gone: As a result of Stewie's time traveling to save Brian. Since Brian wasn't run over, the Griffins never got a new dog.
- Temporary Substitute: To Brian.
- Weaksauce Weakness: Being told bad news about Italian-Americans can give him heart problems. Telling good news has the opposite effect on him.
- We Hardly Knew Ye: Only appeared in two and a half episodes, although he is seen at the end of "The Boys in a Band".
- Debut: "Married ... with Cancer"
An adventurous woman, who wants to spend every day like there's no tomorrow. This is because she has cancer, and there just might not be a tomorrow for her, sometimes. She became Brian's wife. Voiced by Casey Wilson.
- Aw, Look! They Really Do Love Each Other: She and Brian had one of these, at the end of "Dead Dog Walking", where they realized that being married isn't going to be as perfect as they think it is.
- Disney Death: At the end of "Married ... With Cancer", she choked to death on a nacho. At her funeral, she spontaneously gasped for air, and rose from her coffin, happily exclaiming that she was alive.
- Fat Slob: Although she started off as a thin, pretty woman, she turned into a repulsive land whale, shortly after marrying Brian.
- Hot Guy, Ugly Wife: After becoming fat, she became very big and repulsive.
- Like You Were Dying: How she meets Brian and this part of the reason as to why they got married.
- Reality Ensues: The reason for her weight gain and death. You see, chemotherapy has nausea as a side-effect, in which case, when she finds out she's cancer free and so she doesn't have to do chemo anymore, she eats to the point of obesity, along with having a lot gas, as she can keep things down. Unfortunately, it's her gorging herself is why she died (the first time), as she was choking on a nacho in one of her food binges and appears to also have a heart attack.
- The Topic of Cancer: Surrounds her, as she is a victim of cancer.
- Unwanted Spouse: Shortly after marrying Brian, she almost instantly became this.
- Walking Spoiler: There is virtually nothing that can be said about this character and her legacy, that won't spoil a major plot point in the story.
- We Hardly Knew Ye: Died at the end of "Dead Dog Walking", the episode right after her debut.
- Your Days Are Numbered: Dr. Gravitas told her that she only had a month to live, before cancer took her away.
- Debut: "Wasted Talent"
Original founder of Pawtucket Patriot Ale and parody on Willy Wonka. Voiced by Michael McKean.
- Alliterative Name: Pawtucket Pat.
- Benevolent Boss: Much like Willy Wonka was to the Oompa Loompas, he is a kind and caring boss to his Chumba Wumbas.
- Big Entrance: Introduced himself, by pretending to be assassinated, so he could shake up the audience, before revealing it was all staged.
- Cool Old Guy: For such an old man, he sure is pretty cool, inventing Quahog's finest beer, and doing tons of crazy new things with it in his factory.
- Living Legend: Famous for being the inventor of Pawtucket Patriot Ale.
- Mad Scientist: Pat has come up with tons of crazy ideas on things to do with his beer. He even made a wind tunnel, meant to emulate the effervescent fizz that comes off of people's beers.
- Magical Flutist: Summons his Chumba Wumbas, by playing the flute.
- Musical Exposition: "Pure Inebriation" gives some good insight to the kind of person he is, and the legacy he's led.
- Narrow Parody: Of Willy Wonka from Charlie and the Chocolate Factory.
- Nice Hat: Wears a giant can of Pawtucket Patriot Ale on his head.
- Put on a Bus: In "Jungle Love", it was briefly mentioned that he sold the brewery to Angela, and was never seen or mentioned again.
- Quirky Curls: His hair comes in quirky red curls.
- The Wonka: Clearly. He is a parody on the trope namer, after all.
- Debut: "Jungle Love"
Peter's boss at the Pawtucket Brewery who sexually harasses him. Voiced by Carrie Fisher.
- Actor Allusion: Angela played Mon Mothma in the third Family Guy Star Wars parody episode, "It's a Trap!" Angela's voice actor, Carrie Fisher, played Princess Leah in the actual Star Wars movies. Interestingly, Lois, who was playing Carrie Fisher, in the parody, said that she didn't like Mon Mothma.
- Control Freak: She's a rather uptight boss.
- Double Standard: Rape, Female on Male: Her sexual harassment of Peter in "Peter-assment" is Played for Laughs, and Lois brushes Peter off when he tells her of it.Peter: I was sexually harassed at work todayLois: What?Peter: That's right. Angela grabbed my assLois: So? A woman can't harrass a man.Peter: Why not?Lois: Well, men are supposed to like being touched by women. It's not harrasment if you like it.Peter: But I didn't like it.
- Gonk: In "Baby, You Knock Me Out", Angela was a ring girl in a bikini, which showed off every nook and cranny of her wrinkled, droopy, repulsive body, much to the absolute disgust of everybody in the audience.Angela: Shut up! This took a lot of courage.
- I Just Want to Be Loved: In "Peter-Assment", she said that as an ugly, unmarried, old woman, she was very sad and lonely, and desperately wanted an attractive young man to have sex with.
- Informed Deformity: While she looks rather plain, in-universe, she's apparently so hideous that even Quagmire wouldn't have sex with her. "Baby, You Knock Me Out" sheds some light on this when she wears a bikini with her fat spilling out of it, but this isn't something one would see in her usual outfit.
- Killed Off for Real: Following the death of her voice actor, Carrie Fisher, Angela's character had to be written off the show. So, in the episode, "Pawtucket Pete", Angela's funeral took place, and an interracial couple known as Bert and Shelia, that took her place as the new bosses of Pawtucket Brewery.Peter: I may have lost a boss, but Heaven has gained a princess.
- Killed Offscreen: She gets killed off-screen in "Pawtucket Pete". It was only mentioned in dialogue, that her cause of death was swimming less than 20 minutes after eating.Peter: That's a real thing, kids. Listen to your mothers.
- Laser-Guided Karma: Angela sexually harassed and pressured Peter to have sex with her. So he made her think he was granting her wish, by dry humping her, with Mort, hidden under his clothes, who was doing all the real work.
- Meet the New Boss: She isn't really all that different than Mr. Weed, other than the fact that she's harder on Peter, and isn't subject to a bunch of gay jokes.
- Prim and Proper Bun: To highlight her strictness.
- Reasonable Authority Figure: Strict though she may be, Angela isn't an outright Bad Boss (aside from her "Peter-assment" debacle, that is), and is far more willing to put up with Peter's extreme antics than most white collar bosses would be. She's also quite happy to give her employees cigarette breaks at will, and isn't unreasonable in what she tasks them to do.
- Redeeming Replacement: After the death of Peter's relatively easy-going boss, Mr. Weed, Angela became his eventual new boss, She was put in the show to be someone, who would not put up with Peter's shenanigans. Angela is everything a boss of someone like Peter should be. Stern, strict, and equipped with zero tolerance for BS.
- And when Angela died, Bert and Shelia became redeeming replacements for her. These bosses were a pair of ridiculous clowns, who also didn't tolerate Peter's nonsense, but they went about stopping him in a more comical, "Bugs Bunny" sort of way. They fought fire with fire, by forcing Peter to do embarrassing, ridiculous, nonsensical jobs. For once, Peter got a taste of his own medicine, and he realized how annoying it was, when he acted that way in front of others.
- Smug Snake: When she harasses Peter.
- Take This Job and Shove It: Zig zagged, when Peter quit his job in "Lottery Fever". He started off by politely telling Angela that he will be leaving his job, in the nicest way possible, but then ending it off, by telling her that he just shat on her desk.Peter: Angela, I just want to thank you for several extremely pleasurable years working here. Certain events have created a situation, where I am no longer in need of employment. But I would be remiss, not to thank you, and there is a giant poo on your desk.
- Debut: "Jungle Love"
Peter's mentally challenged co-worker at the brewery. Voiced by Mark Hentemann.
- Alcohol-Induced Idiocy: "Underage Peter" reveals that his behavior is a result of constantly being drunk, not mental disability.
- The Bus Came Back: Opie was fired from his job in "The Blind Side", and he left the show for quite a while, save for a few cameos outside of work. However, in "Pawtucket Pete", he was causally shown as an employee again, with no reason given. It can be speculated that because Angela (the one who originally fired him), passed away, the new bosses allowed him to have his job again.
- Cloudcuckoolander: Even Angela doesn't understand his ridiculous methods, yet he somehow manages to get things done.
- Crazy Homeless People: Implied to have become this; he can be briefly seen sleeping on the sidewalk in "Point of Stew" segment of "Family Guy Viewer Mail No. 2".
- A Date with Rosie Palms: Was fired when it was discovered he was constantly masturbating behind his desk.
- The Ditz: Subverted in Underage Peter, as he was actually drunk
- Fish Eyes: His eyes are shown as this in his first appearance, however, this is subverted in Underage Peter where we find he was drunk the whole time, in which case, his eyes are shown as normal.
- Intelligible Unintelligible: Well, Angela and, in later seasons, Peter can understand him.
- Laser-Guided Karma: Kept jacking off at work, getting himself fired. This is especially unfair, considering everything Peter's done, without getting fired. In fact, Peter had sex with Lois, on the worksite in "Whistle While Your Wife Works", so this is totally unfair.
- Noodle Incident: At first, it wasn't known why he was fired, besides Peter saying, "Oh well, it's no wonder they finally caught you doing that in here. I mean the underside of your desk looks like Carlsbad Caverns."
- But let's dissect this joke. Calsbad Caverns is a cavern, known for it's big white stalactites, coming down from the ceiling. So, what could Opie have been doing at work, to get the underside of his desk, (where his crotch usually is), to look like that?
- Only One Name: He's one of the characters, who hasn't had their full name said.
- Put on a Bus: After being fired from the brewery in "The Blind Side," and making two blink-and-you'll-miss-it cameos in "Family Guy Viewer Mail No 2" and "The Simpsons Guy", Opie suffered a long absence from the series, before finally returning in season 14's "Underage Peter."
- The Stool Pigeon: Opie is a total snitch in the workplace. Peter warned Lois about this in "Whistle While Your Wife Works", but Lois didn't care and proceeded to have sex with him, while Opie watched.
- The Unintelligible: Opie only makes rambunctious, slurred, gibberish noises, instead of actually talking. As revealed in "Underage Peter", this was on account of him being stone cold drunk at all given times.
Peter's deaf co-worker. Voiced by Marlee Matin.
- Convenient Replacement Character: For Opie, after he got fired.
- Reading Lips: She can do this, making for easier conversations with hearing people.
- Reality Ensues: In Peter's Def Jam, she points out that the whole "heightened senses thing" is a myth and that Peter is more likely to be hit by a bus in the first three months.
- Satellite Character: She doesn't have too much characterization outside of being a Peter's coworker at the brewery.
- Token Minority: She is deaf.
- Debut: "Chick Cancer"
A foreign guy at work, who laughs at everything. Voiced by Mike Henry.
- Annoying Laugh: He can be very annoying to other characters, because he's always laughing at everything.
- Catchphrase: O-ho-ho, yes!
- Chuck Cunningham Syndrome: Fouad was one of the benched characters, who appeared in "A Lot Going on Upstairs". Since then, he's returned to the show as a regular character again.Peter: [sidelines Stewie] Don't worry, you'll be back soon.
- Don't Explain the Joke: Every time someone tells a joke around him, he laughs and then explains why it's funny.
- Flat Character: Really does nothing outside of laughing at everything, and his appearances are always brief.
- The Friend Nobody Likes: Peter regretted inviting him to his movie premiere of Steel Vaginas in "Chick Cancer".
- The Hyena: He laughs at everything.
- The Illegal: Peter suspected that Fouad was in illegal immigrant in "Padre de Familia".
- Profiling: Fouad was a suspect of illegal immigration, simply because of his race.
- Running Gag: It's a running gag for him to show up and laugh at random things.
- Signature Laugh: O-ho-ho!
- Token Minority: He appears to be a person of Arab ethnicity.
- Debut: "Pawtucket Pete"
An interracial couple, working as the new co-owners of the Pawtucket Brewery. Voiced by Bryan Cranston (Bert) and Niecy Nash (Sheila).
- Bad Job, Worse Uniform: One job they gave to Peter was making him the "recyclable". Not only was he basically a walking trash can, but he also had to wear a giant flag on his butt, so people in cubicles could see him walking by.Chris: Is that a promotion? Because it doesn't look like a promotion.
- Benevolent Boss: They temporarily became this in "Trans-Fat", when they thought Peter was transgender. They have him/her a "benefit package", allowing him fewer work hours, higher pay, and his own personal masseuse.
- Black Gal on White Guy Drama: These two are the very embodiment of this trope. It's even been brought up that Sheila's parents are not happy with her marrying a white man.
- The Dividual: They are in seldom seen apart and they often consider themselves to be the same person. They sometimes even finish each other's sentences, use each other's names, and accept people addressing them as "Beila" and "Shurt", since there's really no point in addressing them separately.
- Finishing Each Other's Sentences: Bert and Shelia do this to an extreme, by saying one word at a time.Shelia: HiBert: It'sShelia: MeBert: SheliaShelia: AndBert: MeShelia: Bert.
- Happily Married: The two are never arguing about anything.
- Lethally Stupid: Bert and Shelia mean well, but their ignorance causes them to make rash decisions and put their employees through hell, without them trying to do anything bad at all.
- Lust Object: Sheila is this to Peter, as on multiple occasions, he's exhibited a not-so-subtle sexual attraction to her.Sheila: Hello, Peter.[Peter sweeps all his supplies off his desk and gets on top of it.]Peter: Alright, Sheila. Let's do it right here on the desk.Bert: No, Peter. It's not that.Peter: Sorry, I thought I was picking up on a vibe.
- Meet the New Boss: Bert and Shelia replaced Angela, after she died.
- Nice Guy: They are relatively nice bosses to Peter, even if their stupidity, leads to him getting terrible jobs.
- Parental Marriage Veto: Shelia's parents are not happy with her, being married to a white guy.
- Perpetual Smiler: Unlike Peter's previous bosses, Bert and Sheila always wield a casually chipper attitude and carry around nice happy smiles on their faces. If Peter wants to make them angry, he's going to have to do something pretty big, like flood the building, as he did in "Family Guy Lite". And even then, they forgave him quickly.
- Portmanteau: They can be addressed as "Belia" or "Shurt".
- Salt and Pepper: Bert is Caucasian, and his wife, Shelia is African-American.Peter: Two sets of disappointed parents, right there.
- Where Da White Women At?: Sheila is the heterosexual female version of this, apparently.
- Debut: "Fifteen Minutes of Shame"
The eccentric mayor of Quahog. Voiced by Adam West.
- Adam Westing: Obviously.
- The Character Died with Him: After the real Adam West died.
- Cloudcuckoolander: The biggest in the series. West brings his own creamed corn to the theater because the creamed corn they have there is too crunchy. He once dispatched the entire Quahog police force to Colombia to rescue the heroes of Romancing the Stone. He chases people off his property with a Cat Launcher.Adam West: My God! Someone's stealing my water!
Meg: But it just went down the drain.
Adam West: They hit when you least expect it.
- His strategy to distract people from the "Dig 'Em" scandal—jingle keys from his window. Then he gets hit by someone throwing a brick and starts to bleed.
- In one episode, he hears Stewie shouting in horror and believes that Quahog is trying to start a shouting match with him.
- Comically Missing the Point: When he sees a traumatized Peter Griffin running from his doctor in the nude after an attempted prostate exam:Adam West: Ugh, get a tan.
- Corrupt Politician: He has wasted thousands of the taxpayers' dollars on finding out what happened to the water he pours on his plants and on a giant gold statue of Honey Smacks cereal's mascot, "Dig 'Em" the frog.
- Crouching Moron, Hidden Badass: When he kills the Noid.
- Fourth Date Marriage: With Carol in Brothers and Sisters, as he proposed to her after a date.
- The Jail Bait Wait: Adam West falls in love with Meg, but is willing to wait until she's mature enough for a full romance (either 18note , 21note , or 25note ).
- He also does this to shield her from a potential erupting scandal, as he's used to scandal and scrutiny, but doesn't want Meg's life to be ruined because of it.
- Killed Off for Real: After the real Adam West's tragic passing, he was shown as a ghost in "No Giggity, No Doubt" and later confirmed to be dead in "Adam West High".
- Obfuscating Insanity: In "Dr C and the Women", Cleveland (acting as a therapist) surmised that West's wacky persona was merely a calculated ruse to distract others from his dark, criminal and sociopathic tendencies, to which West flat out tells him he's completely right, before putting spaghetti on his head. Later on, West returns to Cleveland's practice, announcing that he has killed several people (while wearing ducks on his feet).
- Debut: "Death Has a Shadow"
- Ambiguously Brown: While it is usually assumed that Mr. Weed is Latino due to his accent and second voice actor's ethnicity, his ethnicity is never stated outright, neither Jonathan Weed nor Bermudagrass are Spanish names, and Butch Hartman voiced him without an accent in the pilot pitch. As a result, some fans believe him to be Middle Eastern or French, among other ethnicities.
- Ambiguously Gay: Compared to Mr. Waterman on The Cleveland Show, the closet isn't as transparent with Mr. Weed as it is with Mr. Waterman, but there are clues that Mr. Weed was gay (or, as Peter described him, "an effeminate weirdo."), like when he hired a hunky baseball player while wearing X-ray glasses, or Peter saying he saw the new baseball player "bench press" Mr. Weed in the locker room, or his interest in Michelangelo's Statue of David's penis and Peter's "Mr. Zucchini Head" toy, or the beginning of Mr. Weed's video will, which has him talking to his (male) one-night stand while making breakfast. The ambiguity is likely due to how early of a character he was; the Quest for Stuff app game is a little clearer about it.
- Killed Off for Real: Choked and died on a dinner roll in the episode "Mr. Saturday Knight", right when he was about to give Peter his promotion.
- Reasonable Authority Figure: From what we saw, he was a pretty fair employer. Despite Peter's stupidity causing him problems note , he still gave Peter plenty of chances to fix his mistakes. And when Peter impressed him with a dinner invitation, he gave him a big promotion.
- Debut: "Death Is a Bitch"
The Griffin family's doctor. Voiced by Seth MacFarlane.
- Camp Gay: During Quagmire's operation transplant, Hartman claims he's not gay since he doesn't transplant a penis to Quagmire after he lost his manhood to a shark. However in "Hefty Shades of Gray", it is revealed that he has a husband named Ramirez.
- Depending on the Writer: In some episodes (during later seasons), he slides between being a competent doctor or terrible one.
- Informed Flaw: While the later seasons make numerous jokes about him being an incompetent quack who possibly never went to medical school we have yet to see him give a bad diagnosis, or screw-up an operation or surgery.
- Running Gag: He'll say something that sounds like it's bad news for his patient, then immediately reveal he was talking about an unrelated matter ("That liver's got to come out...of the microwave, or it'll dry out!"). The later seasons have him accidentally switching the last and first words of his sentence, usually when giving a diagnosis; then laughing about it. The listener, usually Lois, is not amused. ("Your coma's in a daughter.")
- Took a Level in Dumbass: For the first few seasons, he was a mostly competent doctor with a quirky sense of humor as his one failing. In recent years, he has become a joke of a physician, with a severe lack of medical knowledge, and is implied to have several botched procedures under his belt.
- The Unseen: He mentions his children several times, often during his aforementioned schtick, but none of them have been seen to date.
- Debut: "Let's Go To The Hop"
The principal of Adam West (formerly James Woods Regional) High School. Voiced by Gary Cole.
- Ambiguously Jewish: Peter claims to see him attending synagogue offscreen in "When You Wish Upon a Weinstein," but he has a quite WASPish name and encourages James Woods High School's students to pray to "the Christian God" in "Secondhand Spoke." He could have converted, or Peter could have mistaken someone else, such as the principal of Chris' school at the time, for him (he also claimed to see Bill Nye the Science Guy in the synagogue, who isn't Jewish either).
- Divorce Is Temporary: Goes through an ugly divorce in season 15's "The Peter Principal." The next season, he is inexplicably married to his ex again, and goes through another unpleasant spat with her.
- Reasonable Authority Figure: He was mostly this in his much earlier appearances.
- Debut: "Jerome is the New Black"
A man Peter befriended when Cleveland first left Quahog. Peter grew paranoid when he found out Jerome and Lois used to date, but his fears proved to be unfounded. Jerome currently runs the Drunken Clam following the death of the previous owner, Horace. Voiced by Kevin Michael Richardson.
- The Ace: Jerome is a skilled athlete, EMT, cook, and is apparently, according to Lois, a glorious lover. He's also incredibly nice (although he does have his asshole moments like almost every other character in the show). Later on, he also becomes a great bartender when he takes over Horace's bar after the latter dies.
- Ascended Extra: Appeared in one Season 8 episode before becoming a recurring character later on.
- Dark and Troubled Past: In "Follow the Money", he reveals that he lost both his first wife and a daughter in an accident after his weather.
- Double Standard: His views regarding interracial relationships: He believes white men only go out with black women as a "novelty", yet he considers his former relationship with Lois as a "beautiful experience".
- HeelFace Turn: At the end of "Baby Got Black", when his daughter, Pam, asks, "Is that what you wanted me to learn, Daddy?". He realizes that, just because he's had negative transgressions involving race, doesn't mean his daughter has to have them.
- Jerkass Ball:
- Grabs it really hard in the episode when Chris starts dating his daughter Pam. He reveals what a horrible racist he can really be when he reveals that he doesn't want his daughter dating a white guy, whereas Peter is completely fine with it and is rightly appalled by Jerome's attitude. He even says that black people can't be racist and tries to justify his behavior by citing some of his own bad experiences, both half-assed excuses for trying to keep his daughter from dating someone who's white. Thankfully, he finally sees the error of his ways by the end of the episode.
- In another episode, he openly and callously tells Cleveland that the only reason he started hanging out with him is because they're both black guys, and that he wouldn't be friends with him otherwise.
- Memetic Badass: Treated as this in-universe.
- New Old Flame: Subverted. He and Lois used to date years ago, but they're just friends now. That didn't stop Peter from getting jealous though.
- Parental Hypocrisy: Again, he, a black man, dated Lois, a white woman and objects to his daughter Pam dating Chris, Lois's son.
- Sixth Ranger: Peter initially wanted him to fill Cleveland's vacancy as the token black guy of their group.
- Debut: "Chitty Chitty Death Bang"
Recurring character with many jobs. Voiced by Mike Henry.
- Ambiguously Brown: Though he's speculated to be Latino/Hispanic.
- Camp Gay: Humorously, he shares the same voice with some of the cutaway characters.
- Catchphrase: "Oh nooooo! and "I knooooow!"
- Characterization Marches On: In his very first appearance, it was kind of implied that he was a pedophile (or, at the very least, can't tell when things come out wrong). In all subsequent appearances, he's easily the nicest character in the whole show and happily living with his boyfriend Jeffery (though he is a smidge irritated that they aren't married yet).
- Nice Guy: Probably one of the nicest characters in the whole show, which depending on the episode is really saying something.
- O.O.C. Is Serious Business: He nearly loses his shit in "Friends of Peter G" when Peter and Brian bring alcohol in the very meeting designed to help people get over their addiction to it. He gives in, but still.
- Token Good Teammate: To the entire cast. Even Meg can be pretty bad compared to him.
- "Well Done, Son!" Guy: Implied in "Petergeist".
- Why Do You Keep Changing Jobs?: He gets around in the job market.
- Debut: "A Fish Out of Water"
A sailor/pirate with four wooden limbs. Voiced by Seth MacFarlane.
- Ambiguously Jewish: Levine is a Jewish surname, though otherwise there's nothing Jewish about him. In a deleted scene for one episode, he was shown attending the same church as the Griffins
- An Arm and a Leg: His whole torso is wooden, not just his arms and legs.
- Artistic License Biology: This was lampshaded in one episode concerning his wooden torsoPeter: How are you even alive?
- Handicapped Badass: He is able to pull off some feats that one wouldn't normally expect from someone with a mostly wooden body.
- It Is Pronounced Tro Pay: His name is pronounced "SHAY-mus".
- Multiple-Choice Past: The reasons for his lost limbs varies according to Rule of Funny.
- Running Gag: He tends to melodramatically explain the same event multiple times and then state the same event shortly and bluntly.
- Debut: "Death Is a Bitch"
- Ambiguously Jewish: He's got a Jewish Mother, anyway.
- Deadpan Snarker: Mainly as Norm MacDonald.
- Death Is a Loser: Death's a geek that still lives with his mother, can't get a date and breaks his ankle trying to chase Peter. Who he mistook for being dead just because Peter faked his death on a form.
- Death Takes a Holiday: Part of a first-season episode.
- Disappeared Dad: Makes an off-hand comment about his dad not being around anymore."Man, I wish Dad was still dead."
- Don't Fear the Reaper: He's a pretty nice guy, if a bit of a loser.
- The Grim Reaper: Death is portrayed as an okay guy who just kills people with a touch of his hand.
- I Love the Dead: How he lost his virginity. It Makes Sense in Context.
- Jerk with a Heart of Gold: He's kind of ungrateful, rude and blunt to Lois and Meg in his debut episode, but he's still a pretty decent guy who agreed to spare Peter and has often helped him out quite a few times.
- Jerkass Has a Point: Death is sick of being labeled a bad guy because he's doing a job that has to be done, which is shown to be exactly right as we see how reckless and stupid people would be if they knew they couldn't die.
- Only Sane Man: Yes, the Grim Reaper is one of the sanest people in this show. Let that sink in.
- Put on a Bus: Wasn't seen for a while after season 5, but later subverted as he started appearing again.
- Screaming at Squick: In one episode when Peter tries to get Death a date, he goes on about what they need to do like getting nice clothes and visiting a salon. As Peter is talking he pulls down Death's hood and from behind Death's head simply looks like a skull (with insects and a snake crawling all over it), but from Peter's point of view it's so horrible that he screams in terror then goes right back to talking normally to Death as though nothing happened. Once Death walks away, Peter promptly vomits.
- The only clue we get about Death's true face is when he's invited over for dinner at the Griffins' house. He inserts an entire turkey leg into the darkness under his hood and pulls it out a second later, meat picked clean from the bone.
- There was a brief reveal of his face in the episode where the people of Quahog were drinking Pawtucket Ale for a chance for the Golden Ticket to tour its factory. He came to reap one such group who had died of alcohol poisoning then decides to give the contest a try. He picks up a beer, pulls back his hood (revealing it to be a normal skull seemingly lacking the cosmetics Peter was horrified at), and uses his eye socket to pry the cap to the beer.
- The only clue we get about Death's true face is when he's invited over for dinner at the Griffins' house. He inserts an entire turkey leg into the darkness under his hood and pulls it out a second later, meat picked clean from the bone.
- Debut: "Quagmire's Dad"
- Closer to Earth: The only real quirk that Ida has is being transgendered (with her being Camp Straight pre-operation as a result of her gender dysmorphia). Beyond that, she's almost always consistently grounded and rational, a stark contrast to most of the other characters on the show.
- Easy Sex Change: She's having sex with Brian on the day after the the operation.
- Good Parents: Both pre-op and post-op, Ida has always been a supportive and loving parent for Quagmire. This is notable due to the amount of screwed up parents and families on the show, including Quagmire's mother. It's implied that had Dan been more physically present for Quagmire's childhood (he was a soldier away from home), the latter wouldn't have such a ludicrous sex drive.
- Mistaken for Gay: Yes, gay and being transgender are two different things (even if Peter and Lois say otherwise).
- Nice Girl: Ida is a very benevolent individual who only wants what's best for her son and for other people.
- Older Than She Looks: Taking into consideration that Quagmire is 61. Even more so after the sex reassignment surgery.
- Rebuilt Pedestal: Quagmire greatly admires him until he reveals his gender identity. Later, Quagmire realizes that he was too rude about the situation and accepts the sex change (and he's the only character who really does so).
- Retcon: In "Quagmire's Dad" it was said that Ida kept his penis but had it turned inside out in order to stimulate a vagina. Fast forward to "The Unkindest Cut" where it's shown that he had it removed after the sex change by giving it to his son as a replacement after his penis gets bitten off by a shark.
- Retired Badass: Pre-operation, Dan Quagmire was a highly decorated naval officer.
- Transgender: Everyone except Quagmire treats her as a joke and/or disgusting.
- Debut: "Jerome Is the New Black"
Glenn Quagmire's little sister who was in an abusive relationship with Jeff Fecalman. Is voiced by Kaitlin Olson.
- Broken Bird: Her relationship with Jeff leads to her being this.
- Broken Tears: Brenda at the end of the episode with her abusive boyfriend.
- Extreme Doormat: Despite Quagmire encouraging her to leave Jeff, she agrees to marry him. Even Joe agrees she's this. What's worse, in the episode that featured her and her abusive relationship, she never grows a backbone and realizes that she doesn't deserve the shabby treatment her boyfriend gives her, meaning, if she comes back, she'll most likely have yet another abusive boyfriend.
- Horrible Judge of Character: A rather unfortunate example, as she never truly realized that Jeff was bad for her.
- Marital Rape License: From what we've seen of her and Jeff's relationship and that she's pregnant, it wouldn't be much a stretch to say this happened.
- Morality Pet: For her brother Glenn. She is one of the few people to bring out his somewhat noble aspects.
- Reality Ensues: For why she's a Broken Bird, due to Jeff to abusing her, she's gotten used to it. This also plays into why she doesn't leave him, even at everyone else's prodding.
- Sibling Yin-Yang: She's gentle and kind unlike her sex offending brother.
- Sudden Name Change: In "Jerome is the New Black," Quagmire's sister was named "Harriet", and Kaitlin Olson didn't voice her.
- What Happened to the Mouse?: She hasn't been seen since Screams of Silence and it's not clear what happened to her (or her unborn baby) afterwards.
- Debut: "Believe It or Not, Joe's Walking on Air"
A lazy, stubborn, kleptomanic Hispanic housemaid who once worked at the Griffins' residence and pops up elsewhere on occasion. Voiced by Mike Henry.
- Ascended Extra: Debuted in a Cutaway Gag, she became a "regular" character on the show interacting with the other "normal" characters.
- Catchphrase: Three.
- "No, no... I stay."
- "Need more lemon Pledge."
- "No, eh, no."
- Charles Atlas Superpower: In "Space Cadet", upon learning that the Griffins are out in space and might not come back (they do, of course), she takes their home. Not simply taking over inhabitance, but literally dragging the house to her neighborhood.
- Creepy Housekeeper: Not so much creepy, as she is annoying and weird
- Determinator: She will never take no for an answer. She'll even refuse to be fired.
- Early-Bird Cameo: She first showed up in the season 6 episode, Believe It or Not, Joe's Walking on Air, where she was asking for more lemon pledge
- Jerkass: When she worked for the Griffins, she played loud music while cleaning and refused to switch it off, wouldn't go home because it was raining, which led to her sharing a bed with Chris (and taking all the covers), and stole some of Stewie's play money (even taunting him when he demanded it back).
- Karma Houdini: She once literally stole the Griffins' entire house, as in, "She picked it up and dragged it back to her bad neighbourhood." She was never called out or arrested for this, though who would want to?
- Sticky Fingers: In a couple of episodes. In "Dog Gone", she takes a lamp (after Peter told her not to throw it away) and, in "Space Cadet", she takes the entire house of the Griffins when she thought they were dead.
- Stubborn Mule: When the Griffins tried to fire her (in Dog Gone), she wouldn't budge
- The Thing That Would Not Leave: In "Dog Gone", the Griffins fired her, yet she still came into work, and she wouldn't leave even when paid to, forcing Peter to knock her out with chloroform and leave her on Joe's porch. Not to mention that she shared a bed with Chris when it was raining one night.
- You No Take Candle: Played straight when she first appeared (for example, she would say "I take home?" instead of "May I take it home?"), however, this seems to be downplayed in her later appearances.
- Debut: "Whistle While Your Wife Works"
Brian's girlfriend during season 5. Voiced by Drew Barrymore.
- Ambiguously Jewish: Played for LaughsJillian: How do I know if I'm Jewish?Brian: Are you Jewish?Jillian: No.Brian: There you go, champ.
- Ascended Extra: She was supposed to be a one shot character, however, they liked her character so much that they decided to make her a regular.
- Brainless Beauty: Low in intelligence, but making up for it with her attractiveness and friendly disposition.
- Camera Fiend: She's a photographer, as mentioned by Brian while defending her. Stewie mocks her for it."That is so lame! Every hot girl who can aim a camera is a photographer. Oooooh, you took a black and white picture of a lawn chair and its shadow, and developed it at Sav-On. You must be so brooding and deep."
- Chuck Cunningham Syndrome: Following her cameo in Season 12's "Life of Brian", she wouldn't be seen again until Season 16's "Follow the Money" which aired nearly four years later. Her appearance in said episode also marked the first time she'd spoken since "Valentine's Day in Quahog" from Season 11 which aired more than four and a half years earlier.
- Demoted to Extra: After Season 9, she only appears very sporadically.
- The Ditz: She makes Peter look like a genius. Though she does wise up to Brian thinking she's an idiot and dumps him. She may not be all that bright, but that doesn't mean she doesn't have feelings.
- Dumb Blonde: She is blonde and about the dumbass...Stewie: Now, why in the world would you be embarrassed about dating her?Jillian: Oh, my God, Brian, I was watching something on TV about this guy named Hitler - [gasps] somebody should stop him!Stewie: [to Brian] Are her parents brother and sister?
- Girl Posse: Has a group of not-so-bright gal pals that Brian tries to hang out with at one point. They all make her look like a grad-student by comparison.
- Happily Married: To Derek Wilcox until he is killed by Diane.
- Innocent Fanservice Girl: She shows traces of this in the episode "Whistle While Your Wife Works". When Brian goes to break up with her, she answers the door wearing a Modesty Towel that she soon takes off and wraps around her hair, exposing her entire naked body. She doesn't appear to be seducing Brian intentionally, but being The Ditz, she doesn't realize the effect her nudity is having on Brian (who has sex with her instead of dumping her as planned).
- Interspecies Romance: With Brian.
- Kind Hearted Simpleton: She might be an utter airhead but she's easily one of the nicer characters on the show.
- Nice Girl: Very much so; unfortunately, Brian and (sometimes) Stewie take advantage of her doormat tendencies to no end.
- Debut: "Don't Make Me Over"
Meg's geeky, unpopular friends. Voiced by Alexandra Breckenridge, then Barclay DeVeau, and later Martha MacIsacc (Patty), Tamera Mowry then Christina Milian (Esther), and Natasha Melnick then Emily Osment (Ruth).
- Adorkable: All three of them share Meg's social awkwardness.
- Ambiguously Bi: Ruth once said that Lois was hot but she's also shown interest in boys.Ruth: Your mom's so fucking hot.
- Beautiful All Along: Scammed Yankees revealed that the slightly more conventionally pretty Patty does have a rather hot body.
- Butt-Monkey: Though not nearly as much as Meg, Ruth gets the short end of the stick a lot later on in the series. She was sold as a sex slave with seemingly no one coming to her rescue (and gets her tongue ripped out to boot), people make fun of her last name, her protests against Monsanto are rudely interrupted by Principal Shepherd, and a boy she liked wouldn't kiss her, even after she bought him dinner.
- Butterface: Patty. In the episode "Scammed Yankees", Brian accidentally sees her undress and finds out that she has a beautiful body... aside her face.
- Black Best Friend: Esther.
- Characterization Marches On: In the show's earlier days, they were mostly just generic unpopular girls who served as friends for Meg to talk to, and as far as names went, were only named by the scripts. But at some point in the series, they got more focus, more funny and cynical moments, and even more importance to the episodes, even if that importance is just an idea they give to Meg to advance the plot.
- Chuck Cunningham Syndrome: Meg's group of friends used to include a blonde girl, Beth, who actually debuted before Patty, Esther, and Ruth, but disappeared after Season 6, possibly because the writers noticed that unlike Meg and the rest she's actually very pretty (in comparison to the other three).
- A Day in the Limelight: Patty in the subplot of "Scammed Yankees", which had Brian being interested in her.
- Distaff Counterpart: The idea of Meg having three friends that she hangs with—one of them black—somewhat makes them younger female versions of Cleveland, Quagmire, and Joe.
- Embarrassing Last Name: Ruth's last name is Cochamer. It's pronounced "coke-hamer", but in the boys' room, it's "cock-hammer".
- Even the Girls Want Her: It's implied that Lois is attracted to Patty, or at the very least is jealous of her amazingly hot body.Patty: Hi, Mrs. Griffin!Lois: Hi...hi, Patty.
- Girlish Pigtails: Esther wears a variant in the form of afro-puffs.
- Has Two Mommies: In Fistful of Meg, Patty mentioned in dialogue that she has lesbian parents.
- Informed Deformity: While they aren't exactly pretty, they are regarded as ugly as Meg, even though they look average.
- Nerd Glasses: Both Esther and Patty.
- Only Friends: As Meg admits in "Our Idiot Brian."
- Only One Name: Patty and Esther have yet to have their last names revealed.
- Palette Swap: Ruth's clothes are different in "Leggo My Megg-O", for some reason.
- Redheads Are Uncool: Patty, though this is more implied, as she's in Meg's circle of friends and, apparently, she was considered "dumpy" right alongside Meg, Esther, and Ruth.
- Satellite Character: They mostly tend to show up in Meg-centric episodes or subplots.
- Unexplained Recovery: Ruth in "Leggo My Meg-O" got her tongue ripped out, yet, in later episodes, she's talking normally and still has her tongue.
- With Friends Like These...: Their abandoning of Meg in "A Fistful of Meg". They didn't want to get beat up by Mike because of their association to Meg.
- "Death Has a Shadow"
A gag character who's famous for bursting into the courtroom, exclaiming "OH YEAH!" Voiced by Seth MacFarlane.
- Back from the Dead: Although his death was most likely non-canon since it occured in a cutaway, he appears in later episodes after Evil Stewie hits him with a baseball bat in "The Hand That Rocks the Wheelchair".
- Running Gag: Bursting into the courtroom and exclaiming "OH YEAH" after the trial says "Oh no!" one by one.
- Debut: "The Thin White Line"
A deaf guy who runs around in his underwear while covered in grease. He first appeared at a picnic held by Peter's company, where one of the activities was trying to catch him. Due to his greasiness, this is very hard to do. He apparently used to be a lawyer. Voiced by Mike Henry.
- Addled Addict: North by North Quahog implies that he is (or was) addicted to cocaine
- Belated Back Story: It isn't until "Yug Ylimaf" that we learn why he's deaf and covered in grease; A grease truck exploded right next to him while he was walking to work. The explosion deafened him and the flaming grease burnt off his clothes.
- Early-Bird Cameo: He was first seen in The Thin White Line back in season 3.
- Exactly What It Says on the Tin: Well, he's deaf...and covered in grease.
- Naked People Are Funny: Is usually naked or wearing underwear.
- No Name Given: He's just the "Greased-Up Deaf Guy".
- Debut: "Holy Crap" (Vern), "Blind Ambition" (Johnny)
- All There in the Script: Vern's name is not revealed in the show, and only seen on official scripts.
- Ambiguous Situation: While Johnny was sent to Hell for being a pedophile, Vern's exact fate in the afterlife is never mentioned since hes on the surface world as a ghost.
- Back for the Dead: Their only appearance in Season 5 has them getting killed by Stewie.
- The Bus Came Back: Despite being shot to death by Stewie in "Saving Private Brian", they make two reappearances. First, they are shown postmortem in "Back to the Woods" and much later on, they make a cameo in the opening to "A Lot Going On Upstairs".
- Catchphrase: Vern: "Play me off, Johnny!"
- Continuity Nod: "Back to the Woods" references them in the afterlife due to them being killed by Stewie in their last appearance.
- Early Installment Weirdness: Vern's first appearance in "Holy Crap" had him performing without Johnny in a more low-key manner.
- Everyone Has Standards: Vern makes this clear about Johnny.Vern: You're probably wonderin' why he's in Hell... (stern expression) Johnny liked little boys.
- Fat and Skinny: Johnny is the former, Vern is the latter.
- Killed Off for Real: Their fate at the hands of Stewie.Stewie: They're dead. We're never going to see them again.
- The Roaring '20s: Some of their routines are based on events of that decade, such as the decline of vaudeville and the Fatty Arbuckle scandal.
- Running Gagged: Stewie kills them both in the middle of one of their routines and tells the audience they won't be coming back.
- The Scrappy: Invoked. Stewie thinks of them as these. According to Word of God, the show relied on them too much and fans thought their acts were getting tiresome.
- Signature Song: Johnny plays "Galloping Gertie" by Sam Fonteyn in all their routines (except for "Holy Crap" in which Johnny performed alone).
- The Voiceless: Johnny never spoke in the series.