There are all manners of terrible diseases out there, deadly and incapacitating, annoying and disfiguring, and even a few truly horrifying fates worse than death.
But in the world of fiction (and according to popular belief, in real life as well), one disease stands tall and terrible above the rest- a disease so deadly, so silent, so inevitable, so evil, that its very name has become synonymous with death. A disease whose mere mention provokes feelings of foreboding terror, disgust and paranoia in modern humans: the dreaded Malignant Neoplasm, or in layman's terms, cancer.
There are countless types of cancer, but all share the same defining nature: in cancer, the reproduction of cells goes out of control. Instead of dividing and multiplying in an orderly fashion, as they should, the cells multiply chaotically and violently without stopping, invading nearby parts of the body, and sometimes even spreading further through the bloodstream or lymphatic system. Ideally, cells have several countermeasures against such a destructive chain reaction starting, many emergency fall-back mechanisms meant to destroy the out of control cell before it can cause damage, but once in a while, those emergency killswitch mechanisms fail.
The causes of cancer are numerous, and can include anything from old age, to exposure to certain chemicals (such as the ones found in cigarette smoke), to exposure to great amounts of radiation (this association with the evils of nuclear power or weapons may be part of the reason for the fear of cancer underlying modern society's perception) to sheer bad luck. The truth is, that in the end, nobody can say for sure who will have cancer and when. Right now, your father may be developing cancer, or your girlfriend, or your dog. Even if they've never even been near Hiroshima or Chernobyl, even if they don't smoke or drink, even if they live in a sterile bubble, even if they run 6 miles a day and eat nothing but kale, they may still develop cancer. There is no way to tell for sure without checking, and even if they turn out not to have cancer right now, nothing can assure that they won't develop one tomorrow, or in three minutes.
Indeed, partially because of successful use of the aforementioned "failsafes" most of the human race is still alive, as 90% of the human race technically has cancer at any one time.
It could happen to anyone, any time, and they would die a slow, excruciating death as their bodies destroy themselves from the inside because of a tiny programming error in the coding of a single cell that prevented it from ever hearing the order to "stop multiplying". There would be few symptoms at the beginning, all of them easy to miss, but towards the end, Body Horror will hit in full force as the tumors, black and slimy or bloated and red would become visible over the skin. Or perhaps, they never will, and all you would see is the patient writhing in agony for days before finally finding release in death. Or they could just go out with a single seizure, out of the blue...
Even if the cancer is discovered and medical treatment is available, the fact that cancer is essentially an out of control aspect of the living body means that the only way to treat it effectively is to kill the growing body. Chemotherapy for cancer involves intentionally poisoning a person just enough not to kill them, but to (hopefully) kill the tumors growing in them. The side effects are horrific: over the course of the long, long treatment, chemotherapy and radiotherapy will cast the patient down into the dark depths of the Uncanny Valley, causing them to slowly and painfully lose anything they had of the image of a healthy human being. Hair will fall, nails will break, fat will disappear. They will vomit, and they will wither, and they will cry silently as they are transformed into pale, skinny mockeries of the human form not by a disease, but by the cure, helplessly watching this cruel world from behind lifeless, sleepy eyes.
At its core, cancer is the perversion of the things we hold most sacred on the most fundamental level: reproduction, life, growth, fertility. The brightest and most wonderful things in nature twisted and mutated into something frightening, something repulsive and wrong by a mindless, faceless force that still somehow manages to seem outright malevolent. It is not surprising that just by mentioning the word "cancer", any instance biological horror may instantly become scarier, any scientific experiment more taboo, any associated magic or power evil.
Note that this trope isn't just for cases of cancer appearing in fiction: The Topic Of Cancer means that the word, term, or very concept of cancer is used specifically to evoke that semi-rational, paranoid terror and revulsion and creepiness that are associated with cancer, or with implications that cancer is somehow worse in some way than other diseases or conditions.
The Littlest Cancer Patient attempts to invoke this for emotional torque, often unsuccessfully.
The inversion is The Disease That Shall Not Be Named, where the work avoids saying cancer (or any other given disease) because it's so horrifying.
Not related to the Topic of Capricorns.
- Anti-Tobacco ads like to point out that tobacco use causes all sorts of horrible cancers as an effort to stop people from using Tobacco. Sometimes this comes with graphic images of cancer-ridden cadavers pulled from now dead smokers and/or actual dying cancer patients.
- Used for karmic justice (and the compulsory Body Horror) in Franken Fran - a rich villain hires Fran to extend her life and tries to get her killed to steal her research (fortunately, Fran is ambiguously undead and can live through decapitation). Fran returns to the villain's mansion and finds her Showing Off the New Body - the experimental formula allowed her telomeres to regenerate indefinitely, making her cells immortal...just as the first side effects start to appear, Fran calmly explains that the only cells not programmed to die of old age are cancer cells. She then walks away, leaving her client "immortal" - as a gibbering pile of semi-liquid flesh.
- Another issue had an abandoned girl afflicted by teratomas (a sort of cancer that produces organ tissue in areas it's not supposed to be in), almost completely subsumed by a massive lump of half-formed limbs. This has a happy ending (happy as it gets for this series), however, as Fran is at least able to treat her condition enough for her to re-enter society
- Elizabeta from Gunslinger Girl was a young Russian ballerina who developed bone cancer in her teenage years because she spent a period of her childhood in an area of the Ukraine that was heavily affected by the Chernobyl incident. Due to the generally primitive state of public healthcare in ex-USSR areas, the cancer is not contained properly and by the time Elizabeta arrives in Italy for further treatment, the doctors decide that the best bet would be to amputate her leg before the cancer spreads. Realizing that she will never be able to dance again, Elizabeta tries to kill herself. This is remarkable because of all the other girls' backstories, this one is the second most detailed (by far) and the most often referenced (usually by people expressing pity over the poor, poor girl with the cancer), while the stories of girls who were nearly murdered, mutilated by car accidents, raped or born with horrific disfigurements get barely a line. The only story that gets more screen time than Elizabeta's is of the girl who was used as a living prop in snuff porn films. Elizabeta, now known as Petruskha, eventually develops leukemia anyway, and dies peacefully in the epilogue.
- Mitsuki Koyama, protagonist of the shojo manga Full Moon, has a cancer in her throat played for full terror-tragedy value. In her particular case, her dream is to become an idol singer, but the only way to remove the cancer by the point the story begins involves a surgery that would render her permanently mute.
- The symptoms of the Apocalypse Virus from Guilty Crown are explicitly referred to as "cancerous", and constant comparisons to cancer are made. Needless to say, it is quite horrible.
- At the start of Stop Hibari Kun Kousaku's mother dies of stomach cancer. This causes him to be sent to live with an old friend of hers.
- An episode/chapter of Cells at Work! deals with cancer, treating the carcinoma as a Tragic Villain born wrong due to a tissue cell's bad day. Breeding out of control is his way of throwing a Suicidal Cosmic Temper Tantrum.
- The comic perhaps most well-known for this has to be Funky Winkerbean. When it first showed up, it was a serious topic but ended on a hopeful note as Lisa overcame it and resumed her life. Then it came back and she died, and from then on, cancer and the pain it causes has a lingering effect over the characters in the strip. At least one minor character in its sister strip, Crankshaft, has also died from it unceremoniously.
- Used as Fate Worse than Death in one version of Spider-Man - It turns out Eddie Brock has cancer which, through hormonal imbalance, causes fits of rage, ruining his life. The symptoms also attract the symbiote to him. The symbiote wants to take over Peter but ends up attached to Brock and unable to switch hosts again. It has the power to stop the cancer from spreading but can't afford to cure it as it relies on it for food - this leaves Brock superpowered, angry and in constant pain - for the rest of his life. It ended up being curef sometime later thanks to Mr. Negative soon after Eddie surrendered the symbiote to be bidden off. In Donny Cates' Venom it is suggested that Eddie's cancer wasn't actually cancer, but the symbiote manipulating his mind and body to make him think he did, thus they could stay together.
- A minor but very creepy Spider-Man villain Styx was at one point called "living cancer" - he was a victim of Playing with Syringes trying to find a cancer cure by way of Acquired Poison Immunity - by exposing him to mutagens. Instead, it gave him the power to make anything he touches wither and rot. The experience also twisted his mind - if his ability wasn't limited to touch, he would be an Omnicidal Maniac.
- One Incredible Hulk story (probably an annual) had a wealthy cancer patient come up with a convoluted plan to get the Hulk's gamma-irradiated blood in the hopes that this would make his normal cells superpowered and able to overcome the cancer. Instead, the cancer cells were the ones that became super-powered, with nightmarish results. There was a callback to this years later when Hulk learned that one of his old friends was dying of AIDS and refused to donate his blood for fear something similar would happen.
- Doctor Manhattan from Watchmen is extremely distraught to discover that the radiation emitted by his physical avatar gave terminal cancer to people who spent too much time around him. This was actually a ploy by Ozymandias, who gave them cancer himself so that Doctor Manhattan would seclude himself on Mars, where he wouldn't interfere with Ozymandias's conspiracy.
- Ruins: this very Darker and Edgier alternate universe had Bruce Banner transform into a cancerous Blob Monster instead of a green Hulk.
- Vic Sage's battle with cancer forms one of the main storylines of 52. And then he dies of it.
- The drug "Mayfly" from Empowered gives you super intelligence, but will kill you within 24 hours from brain cancer (that is, assuming it doesn't just do that without giving you anything in return). Unless you manage to use your newfound genius in order to survive...as a horrible, grotesque mass of cancerous flesh.
- Possibly the classic Marvel Comics example: the death of Captain Mar-Vell. In his case, it happened in an earlier story when he stopped a villain stealing a container of deadly nerve gas and it leaked during the fight. Mar-Vell managed to reseal it and eventually was given an antidote in time while unconscious, but the gas' carcinogenic effects would later give him fatal cancer, albeit suppressed for years by his nega-bands until it mutated past their resistance and making it impossible to treat without assistance from the Kree medical community, which, needless to say, was a non-starter for a traitor like himself.
- Here's a fun little story for ya. [[Deadpool, a nice young man]] discovers he has the big C and, not wishing to drag it out, refuses chemo. Then he's offered the chance to cure his cancer by Weapon X, who implant a version of Wolverine's Healing Factor in him. Only the cancer and healing factor don't play nice together and their constant struggle winds up turning him into one handsome, crazy son of a hired gun. Ain't that a bitch?
- In the Concrete story "A Remarkable Life", Concrete sprouts antlers that grow uncontrollably and apparently without bound. Chadwick mentions in his blog that the antlers are "a metaphor for cancer".
- In "Strictly from Hunger!" in The Vault of Horror #27 a small-town man was diagnosed with a tumor. After his doctor's rather unprofessional comment that "The malignant one keeps growing till it kills you! 'Tain't no use removin' it!" he went to a witch who promised to hex him so he'd never die. However, she said nothing about curing the tumor, which eventually took over his entire body, turning him into a giant, shapeless lump of flesh which knew only hunger.
- Jane Foster, the long-time love interest of Thor, was discovered to have cancer. Her being the female Thor isn't helping and, in fact, is making things worse as it spreads each time she transforms. It was later revealed that on of Mjolnir's powers was removing poisons from the wielder's body. Since it considered her chemotherapy poison, it removed it and did more damage to her body.
- The original Black Canary, Dinah Drake, died of cancer caused by the radiation from a blast that killed her husband years earlier.
- In the second half of Mark Waid's Daredevil run, Matt discovers that his best friend Foggy Nelson has cancer. Complicating matters is right around this time Matt has gone public with his identity, so people know he's a friend of Daredevil: which means if he checks into a hospital to try and have it treated, any villain who wants to settle the score with Daredevil could target him. This forces Matt to fake Foggy's death while he undergoes treatment in secret.
- In Friendly Neighborhood Spider-Man Vol 2 #1, it's revealed that Aunt May has cancer and she's terrified of letting Peter know. When she finally does, one of the things he does is head for Dr. Strange (he was taking a kid there after he had accidentally broken his arm and the kid had no insurance) and start to ask for help. Strange cuts him off and suggests that he just take the time to be with her. Also, not to take up deals with interdimensional demons (which Peter agrees to).
- In a major aversion to the original depiction, Lex Luthor was stricken with cancer due to his hand wearing a signet ring with a Kryptonite stone in it. They initially lopped off his hand and replaced it with a robotic prosthetic, but it was discovered it had actually spread to the rest of his body, forcing Luthor to fake his death and come back in a clone body.
- Prior to getting hit with one of the worst Continuity Snarls in comics Donna Troy's birth mother had to give her up despite loving her and not wanting to let go because she had terminal cancer and knew she wouldn't live long enough to raise her daughter. Donna's father is never mentioned, only the tragedy of her young mother whose life was cut short by the terrible disease.
- Monty Python's Flying Circus: In one animated segment, a prince sees a black spot on his face, but ignores it. Then he dies of cancer. (It should be noted in at least one version it got changed to gangrene. It was pretty obvious it got changed since the narration changed from a woman's voice to a man's. Then again, it is Monty Python...)
- A bit of an oddball example is in Tommy Wiseau's The Room, wherein the Love Interest's mom flat-out states that she is dying from breast cancer during one scene. This is promptly forgotten and never mentioned again.
- One day, the main character of Phenomenon sees a flash of unearthly light, hears a strange sound and falls unconscious. When he wakes up, he's got super-intelligence and even psychic powers. Turns out he's got a massive cancer in his brain that by complete coincidence happens to enhance certain functions by pushing against rarely activated parts of it. The flash of light was an epileptic hallucination brought upon by the cancer. Oh, and the main character is also dying.
- Sam, the title character in the adaptation of Ways to Live Forever, has leukemia.
- The Matrix:
Agent Smith: Human beings are a disease, a cancer of this planet. You are a plague, and we...are the cure.
- In Brian's Song, the title character dies from testicular cancer which has spread to his lungs, the first symptom of which is an Incurable Cough of Death that he at first attributes to hay fever or allergies.
- In In the Land of Women, Sarah has breast cancer, and we see her dealing with the after-effects of chemotherapy, she has serious talks with her family about what she'll have to deal with, and she has a Heroic BSoD when she finds out how sick she is. Unlike most versions of this trope, however, it's implied she gets better at the end.
- Annihilation (2018) is essentially a cancer metaphor applied to First Contact. A meteorite crashes on a beach and starts to reform the environment and wildlife around it in a hazardous and aimless manner, right down to the laws of physics. Made explicit by one of the first scenes where the main character gives a lecture about cancerous cells to her class.
- Similar to Annihilation and made decades earlier, The Fly (1986) is a metaphor for aging, disease, and death applied to the results of a Teleporter Accident. The protagonist unknowingly genetically splices himself with a housefly, resulting in a Slow Transformation rife with Body Horror (his fingernails come loose, he must vomit on solid food in order to consume it, he develops strange growths, he loses his hair...) that he explicitly refers to as "a bizarre form of cancer" at one point. In his final humanoid stage, before his mutant insectoid form emerges, he resembles nothing so much as a mass of tumors. Writer-director David Cronenberg (who lost his father to cancer) has remarked that audiences would out of hand reject a film that depicts actual aging/disease so graphically, but the fantastic nature of the transformation here gives them just enough distance to handle it while still noticing the metaphor.
- Nux from Mad Max: Fury Road sports a couple of deadly tumors on his neck. He's named them Larry and Barry.
- The story "Metastasis" by Dan Simmons is built heavily around this trope. Apparently cancer is caused by a parasitic race that uses humans as breeding grounds. In effect, each tumor is actually a larva that devours humans from the inside as it reproduces wildly until there is nothing left. The parents then come back and devour their offspring for nourishment occasionally leaving one or two to germinate into an adult.
- Tuf Voyaging has a "cancer creature/living tumor" example in the "Meatbeast" that Haviland Tuf proposes as a temporary solution to S'uthlam's overpopulation induced food shortage.
- Sam, the title character in Ways to Live Forever, has leukemia; the book also has a film adaptation.
- Inverted in The Fault in Our Stars: Both of the main protagonists (and half of the supporting cast) have cancer. They all speak of their condition with a blase-ness that only terminal cancer patients can muster. And people who try to sentimentalize or go emotionally overboard over the condition are heartily mocked.
- This is Lurlene McDaniel's bread and butter. Not only is cancer a major theme of her books, but the stories go into great detail about the diseases, treatments, surgeries, and side effects. These are the kinds of cancer books the above Fault in Our Stars mocks.
- In Gangsta Granny, things turn serious the moment the word "cancer" is mentioned in what was previously a comedy book.
- Lilith's Brood: The Oankali, a Superior Species with incredible powers of Biomanipulation, are uncharacteristically horrified by Earth organisms' ability to develop cancer — even the concept feels completely wrong to their senses. However, once studied, the phenomenon helps them greatly improve their powers.
- The X-Files:
- Scully almost died of alien-induced cancer. Other abductees were not as lucky.
- In one episode the Monster of the Week was a man made entirely of cancerous tissue. He could regenerate the loss of his head and had to eat cancerous tissue removed from surgery patients (he worked in a hospital).
- The villain of "Pusher," Robert Modell, is a man whose inoperable brain tumor came with incredible mind control abilities. With nothing else to live for and excruciating headaches, Modell hired himself out as a mercenary/hitman, using his powers to kill for huge profits. Funnily enough, it was written by the same man who went on to do Breaking Bad.
- In medical tv shows, Scrubs for example, while cancer -is- often shown to be horrible, other types of diseases can be shown to be just as bad at times.
- The series Breaking Bad revolves around the protagonist, Walter White, discovering during the pilot that he has terminal lung cancer. It is this discovery that kick-starts the action of the show.
- An early monologue by Bruce McCullough on The Kids in the Hall had him apologizing to everyone for "causing all of that cancer". He says he did it because he "didn't realize it was such a horrifying disease" and he was "just on a roll".
- In House, now that the oncologist, Wilson, himself has cancer, it's an opportunity for the writers to both show more of their relationship with House, and how firsthand knowledge of what cancer actually does to patients affects their reasoning when seeking treatment.
- Helen Givens from Justified. We learn that she is a cancer survivor during an argument with Arlo in Season 2.
Arlo: I hope you get cancer!Helen: Already had it!Arlo: I hope you get it again!
- In Everwood, Rose Abbott is diagnosed with cancer. She survives, but she suffers horribly, going through chemo and operation procedures. Also, her family is devastated by the fear of losing her.
- Debra and Dexter's mother died of cancer when they were teenagers. Debra once says she can't visit Camilla, their family friend because her suffering would remind her of her own mother too much and she thinks she could not cope.
- Camilla and her husband were friends of Harry Morgan (Dexter's father). They have been heavy smokers all their life. Camilla is already widowed in season one. In season three, she's dying of lung cancer and in excruciating pain. She wishes to die soon to cut short her suffering.
- In the sixth season of Kinpachi-sensei the titular teacher's teenage son is put in a hospital for leukemia treatment. He is at first incredibly stressed over the thought he's dying but eventually loses the attitude and refuses to give in. He gets better and makes a friend with a girl who has bone cancer.
- In NCIS, an old friend of Gibbs comes to him with a request to help his daughter, dying of cancer, to receive closure regarding a suspicious death of one of her colleagues the previous year, and in the course of the investigation, something happens that requires her to need protection. Gibbs assigns Torres to guard duty despite his protests, for reasons that Gibbs apparently already knows. His aloof demeanor leads her to believe that he'd lost someone to cancer before, and at the end of the episode, he reveals that it was a childhood friend turned high school girlfriend.
- On Orange Is the New Black, Rosa is dying of ovarian cancer while in Prison. She is taken to the hospital on a regular basis for chemotherapy treatments. Her doctor says she needs life-saving surgery and gives her three weeks to live if she does not receive the surgery, but the Department of Corrections won't pay for it, and she doesn't have family on the outside that could pay for the treatment. Morello gives her the prison van, so Rosa can at least live out the remainder of her life as a free woman. Rosa runs over Vee, but crashes into a ditch herself and dies.
Rosa: No one fucks with cancer.
- Adam Ruins Everything discusses (with the help of an actual doctor) why "routine" cancer screenings (e.g. mammograms, colonoscopies, Pap smears, etc.) aren't as helpful as they're often touted to be, at least not in younger, healthy people. They can give "false positives" (such as flagging an area of dense tissue as a tumor), and they aren't able to distinguish between different types of tumors (i.e. those that are benign, and those that are malignant, and those that are fast-growing and slow-growing, etc.) This results in patients getting harsh treatments (such as chemo) that they really don't need, or the wrong type of treatment for their particular cancer...plus lots of emotional and financial stress on these patients and their families. The result of this is that many doctors and cancer advocacy groups are now recommending that (if they're not considered "high risk") they start the "routine" screenings later in life, and have them less often.
- In general, high rates of cancer can be found in the Hard Rock / Heavy Metal scene globally and in Japanese Visual Kei, as a result of often frequent and heavy use of alcohol, Everybody Smokes being in effect until The '90s or the 2000s with lots of ongoing smokers and nicotine users still, the toxicity of secondhand smoke in venues before that was outlawed, the toxicity of vehicles if they were bikers or often traveled by motor vehicle, and the toxicity of makeup and clothing and the like, as well as bad diets for many who were poorer. As a result, HR/HM and Visual Kei have many artists who have died from cancer, but also many survivors of the disease if it was detected early enough/they were lucky/etcetera.
- Metallica's Until It Sleeps is about the lead singer's mothers battle with cancer, and the emotional pain of watching it destroy her.
- Jason Isbell's "Elephant" is about a man trying to support a friend dying of cancer.
When she was drunk she made cancer jokes
Made up her own doctor's notes
Surrounded by her family, I saw that she was dying alone
There's one thing that's real clear to me:
No one dies with dignity
We just try to ignore the elephant somehow
- Lou Reed's album Magic And Loss is an entire song cycle about two friends of his who died of cancer.
- Regina Spektor's "Chemo Limo", about a single mother who can't afford the treatment that probably won't save her anyway, and having an Imagine Spot where the doctor tells her she's fine so she can spend the money on a limo ride with her kids instead.
- Nightwish's Higher Than Hope is about DJ Marc Brueland's battle with cancer.
- D&D's Book of Vile Darkness - a Plague Master Prestige Class "cancer mage" gets a sentient tumor as a familiar: the entire idea of the Cancer Mage is that cancer is something disgusting, creepy, and in this case actually, cosmically evil.
- Call of Cthulhu supplement The Asylum and Other Tales, adventure "The Asylum". One of the drugs Dr. Freygan uses to create proto-shoggoths is called Cellular Accelerator. It can heal wounds quickly, but there's a chance it will cause cancer throughout the recipient's body. The victim will be reduced to a mass of suppurating flesh within 2-12 days and die 1-3 days later.
- Amber Diceless Role Playing. If characters with Shape Shifting push themselves beyond their limits while suffering from exhaustion or starvation, they can suffer from Primal Chaos Cancer. Some of their cells run wild, consuming normal cells and multiplying quickly. The rogue cells will eventually attack vital organs, appear on the skin and eat the character alive, turning him into an amorphous blob.
- In Promethean: The Created, the mysterious sixth Lineage are the "Zeka", Prometheans animated and fueled by radiation that have a lot of disturbing, creepy abilities. Among them are the ability to give other people regular, boring old cancer, but if you want to get freaky, you can give them a tumor with a mouth that can speak to them, or a mind control brain tumor, that is implied to cause endless excruciating pain and leave the victim a helpless puppet with full consciousness but no control over their actions. When Zeka use their powers, their "Disfigurement" usually involves huge cancerous masses growing from within them, boiling, bloating, and pulsating as their skin falls off and their eyes melt. Even when not showing their powers, most of them have signs of radiation poisoning or cancer, such as visible tumors on their faces. Then there are the Carcinoma, which is what you get when Zeka tries to make more of themselves and fail horribly: hideous monstrosities made completely out of cancer, with an alien, incomprehensible, malignant intelligence.
- "Hunchback: The Lurching", a fan gameline for the New World of Darkness: As a drinking game, take a shot when the lump is described as "Cancerous", "Malignant" or "Tumorous". Just don't blame me when you lose your liver.
- In Scion, the Titan of the Blighted Earth, Crom Cruach, nemesis of the Tuatha De Danaan, is associated with stillbirth, madness, fungi, vermin, rot, mutation and cancer, and has a very strong theme of the "perversion of life". His minions, the giant fomorians, are generally horribly disfigured, and their ugliness is said to often include tumors all over their body.
- Wit: Perhaps one of the most brutal works on the subject.
- Tig Notaro was diagnosed with breast cancer in 2012, necessitating a double mastectomy. Days after the diagnosis, she performed as she'd been scheduled to but began her set with "Hello, I have cancer. How are you?" Her show became famous for her incredibly matter-of-fact and moving discussion of cancer on top of the other horrors she had endured that year, mixed with the Black Comedy of the absurdity that occurred along with the tragedy.
- In the original Civilization, developing a cure for cancer gave you one happy citizen in every single city, no strings attached.
- The creepy biological MacGuffin from Oni, the Chrysalis, is repeatedly described as being like cancer.
- The page quote comes from Mondo Medicals. Let's just say a certain character is... passionate about the Topic of Cancer.
- By the time of Metal Gear Solid 4, Naomi Hunter, a beloved character who's been with Snake (and the player) all the way since the first game doesn't just have cancer, she's practically already biologically dead from cancer. It's so bad that mere seconds after she deactivates the nanomachines in her body fighting it, she dies.
- Weaponized in StarCraft I by the Zerg Defiler. Their signature ability, Plague, coats an area in acid and carcinomas that can reduce anything to 1 HP, even through Deflector Shields. Defilers themselves are said to be "cancer factories", and their prerequisite building, the defiler mound, is little more than a huge tumor. Presumably, this is to showcase that the Zerg are so adaptable they can even adapt to this and twist it to their advantage; and at the same time, so utterly nightmarish they weaponize cancer.
- The same race also spreads their "Creep", a sort of "rag" of organic matter from which they evolve structures, using "Creep Tumors". In Starcraft II Heart Of The Swarm, Kerrigen even gets an upgrade for it called "Malignant Creep", which makes it spreads faster and further and Zerg units on it stronger.
- That Dragon Cancer is pretty much the game of the trope.
- In [PROTOTYPE], Blackwatch uses a sapient, weaponized cancer as a Restraining Bolt to bring Alex down to normal. It's visible as a reddish mass with roots anchoring it to his left shoulder and locks down most of his abilities.
- In BioShock, ADAM (sic) works "like a benign cancer", changing native cells into unstable stem versions of themselves. Through a little GMO-ing, it can be used to induce superpowers. The withdrawal symptoms, however, are absolutely nightmarish, including the growth of huge tumors and neuro-degeneration into violent insanity.
- In Darkest Dungeon's Title Drop of a Womb Level, you fight parts of the Eldritch Abomination. These include demonic tumors, cysts, and polyps, with the only actually healthy part of it being its white corpuscles.
- Claudia Jerusalem from Dies irae ~Interview with Kaziklu Bey~ is revealed pretty early on that she is dying from terminal skin cancer and is given about a month to live. And despite the fact the the cast is riddled by incredibly powerful magical individuals, it is stated that only Mercurius or Rusalka might have the magical know-how to cure something so serious, neither of which are people the main character Wilhelm would ever want to be indebted towards.
- In Homestuck, Karkat (who uses the trolltag carcinoGeneticist and the astrological symbol of cancer) admits to John he may have given John's universe cancer. And it turns out the cancer is Jack Noir. The fact that he is an Anthropomorphic Personification of a cancer sums up his personality.
- Shows up in more than a few xkcd strips, as Randall Munroe's now-wife had been diagnosed with stage-3 breast cancer during their engagement.
- This has come up in the 2014-2015 arc of Moon Over June, starting when Summer Winters' routine mammogram becomes vastly less so. The treatment has been odd. With one strip starting with Summer confiding to her housemate Hatsuki how awful the chemotherapy is making her feel and her fears that the double mastectomy was not in time to keep it from spreading, then demanding sex because it is the only way she can cope (it's that kind of webcomic).
- Awful Hospital
- A polyp in Fern's leg acts as an obstacle during the Inert Biovessel arc.
- The Immense Thing is assumed to be made from cancer, and has the Fan Nickname Terrortoma.
- Slobs are "greyzoners" (humans/creatures from our neck of The Multiverse) mutated/resurrected by an aggressive, red biomass that acts like cancer on LSD.
- The Parliament is working on spreading a metaphysical disease that is described as "imagine you can catch an aggressive cancer as easily as you can catch a common cold. Now imagine you can catch it from the sound of a trombone or the color purple". It's implied to be the stuff mutating the slobs.
- Although he tried to hide it, Bryce of We Are The Wyrecats eventually reveals that he has a tumor in his brain that will eventually kill him.
- Manly Guys Doing Manly Things: the Commander's not worried about getting lung cancer from his cigar-smoking habit because in the future where he comes from, everyone apparently has cancer, but by this point it's become such an integral part of the human experience that the cancers have formed a symbiotic relationship with humans.
Commander: More like a healin' factor than a disease at that point.
- The Autobiography of Jane Eyre: Jane's estranged evil aunt Mrs. Reed has a brain tumour and is dying. In the book, she had a stroke.
- The Creepypasta A Cure for Cancer has a teen genius obsessed with curing cancer infect his ex-girlfriend with a bioweapon that causes pancreatic cancer, which he thinks will be easy to cure since he engineered it (under contract by the CIA). The plan Goes Horribly Wrong, as the cancer metasizes into every single one of her organs. He remembers one of his proposed cures, which was using stem cells to remap the circulatory system, starving the tumors. This was a bust, however, since he couldn't get enough stem cells or funding(nobody wanted to deal with the ethical ramifications of rendering down feti for them, so he makes a test-tube baby and grows it inside some kind of animal). The disease and cure react strangely, turning her into a zombie-like creature made entirely from cancer.
- Another, entitled simply "Cancer", details cancer treatment in 500AD. It involves cutting off the infected organ with a blunt hacksaw, drinking poison, and being lit on fire. However, it's got a happy ending, as the main character survives the whole thing.
- Played for Laughs in How to Write Badly Well. One technique suggested is "Emphasize Your Villain's Bad Qualities". It stars a Mad Scientist bent on curing leukemia, not for the good of mankind, but to put oncologists out of business and stopping survivors memoirs from being written.
- Played for Laughs in Mortasheen. One option for a lawn is cancer-based Meat Moss.
- The monsters Tyrannitoma and Tumorman weaponize cancer in two separate ways: Tyrannitomas are polyp-like creatures who convert any creature they`re attached to into a huge, sapient humanoid tumor with fantastic strength, and Tumormen weaponize an aggressive form of skin cancer.
- Aqua Teen Hunger Force: "Party All the Time" is a surprisingly sad and serious episode where Frylock discovers the mole on his face has turned malignant, and his friends struggle to support his struggles with skin cancer.
- Archer had an arc in which Archer got cancer. This was the only time in the series that Archer actually took the danger he was in seriously and seemed legitimately worried that he was going to die.
- An episode of Arthur had the school's lunch lady reveal that she had cancer. Significant in that a kids' show addressed it so openly.
- South Park:
- In one episode of The Venture Bros., Brock interrogates one of Baron Ünderbheit's henchmen by grabbing his testicles and squeezing them. But he quickly stops after feeling a lump.
- The comparison of any ethnic group, organization, ideology, political party, company or other collection of people to a "cancer", of which there were historically far too many to count, is an attempt to invoke this trope for political gain. No specific examples needed.