Subtrope of Casting Gag. Liable to be a Large Ham. Expect numerous Actor Allusions. Compare Real-Life Relative. Not to be confused with Old Friend, Remember the New Guy? or Beleaguered Childhood Friend, but can overlap with any of them.
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- In 2022, Progressive paired Flo with Jon Hamm. He and Stephanie Courtney had previously worked together when she played switchboard operator Marge on the first season of Mad Men.
- Episodes 42 and 43 of the Angel Heart anime series involves Ryo Saeba (who is voiced by Akira Kamiya) dating a news reporter voiced by Yuriko Yamamoto. Kamiya and Yamamoto previously played Kenshiro and Yuria in the original 80's version of Hokuto no Ken.
- The Hobbit:
- Martin Freeman's costar Benedict Cumberbatch from the acclaimed show Sherlock is the voice behind Smaug the dragon. One can already imagine Smaug and Bilbo solving crimes in Middle Earth.
- Martin Freeman and Benedict Cumberbatch aren't the only examples of this. Hugo Weaving and Richard Armitage also both appeared in Captain America: The First Avenger.
- And Graham McTavish guest-starred in an episode of Pushing Daisies, where Lee Pace played the main character.
- And Orlando Bloom (as the Duke of Buckingham) and Luke Evans (as Aramis) were in The Three Musketeers (2011) together.
- Interception, the Short Film reunites Alimi Ballard with NUMB3RS co-stars Rob Morrow and Dylan Bruno.
- Into My Heart 1998:
- Claire Forlani and Jake Weber previously worked together on Meet Joe Black.
- Rob Morrow and Jayne Brook previously worked together on Last Dance.
- All Christopher Guest films feature members of his Production Posse in different combinations, but it is particularly noticeable in A Mighty Wind; the Folksmen are played by the three main members of Spinal Tap. The video for a song from their 60s folk-rock phase is clearly a Shout-Out to "Listen To The Flower People".
- Extreme example: In the Mystery Science Theater 3000-featured film Quest of the Delta Knights all sorts of hilariously awkward dialogue of this sort occurs between the Big Bad (David Warner) and The Mentor (David Warner).
Crow: "David Warner, you're under arrest by the order of David Warner!"
- In Maverick (directed by Richard Donner), Bret Maverick (played by Mel Gibson) is in a bank that is held up by a gang, one of whom is played by Danny Glover (Gibson's co-star from the Lethal Weapon movies, also directed by Donner); the two men almost appear to recognize each other, but then dismiss the notion. (Then, to cement the association, as Glover's character is mounting his horse for a getaway he is heard to say, "I'm gettin' too old for this shit!" - Roger Murtaugh's famous catchphrase from Lethal Weapon.)
- In Quid Pro Quo, Dylan Bruno previously worked with James Frain, Joshua Leonard, and Kate Burton previously worked together on NUMB3RS.
- In The Senator Was Indiscreet, a William Powell vehicle, the final scene reveals that his wife, unseen till now, is Myrna Loy, who co-starred as his wife in numerous movies including The Thin Man series.
- Seeing James Spader as the main villain opposing a group led by Robert Downey Jr. in Avengers: Age of Ultron is amusing, considering the two had previously worked together a few times in the 1980s. They actually played best friends in Tuff Turf, as well as slightly antagonistic associates in Less Than Zero.
- John Cho and Anton Yelchin, who played Sulu and Chekov in the Star Trek "Kelvin Timeline" films that started with the 2009 reboot, previously crossed paths before in the 2001 film Delivering Milo.
- Beauty and the Beast featured Jerry Orbach as Lumiere and Angela Lansbury as Mrs. Potts. They were very good friends, having worked together on Broadway and television. Notably, Orbach had a recurring role as hardboiled detective Harry McGraw in Landsbury's Murder, She Wrote.
- Triple Frontier co-stars Oscar Isaac and Pedro Pascal previously both performed in the Off-Broadway play The Beauty of the Father, where the actors formed a long-lasting friendship.
- We Can Be Heroes (2020) features Pedro Pascal and Boyd Holbrook as members of the same superhero team, four years after they co-starred on Narcos as DEA partners.
- One of the best moments of Shark Tale was when Robert De Niro said to Martin Scorsese, "We've worked together for a real long time."
- Tomorrow Never Dies opens with Bond on a mission with M and Admiral Roebuck of the Royal Navy supervising. M (Judi Dench) and Roebuck (Geoffrey Palmer) previously starred together in the series As Time Goes By.
- After being defeated by Son of Havok at Lucha Underground, Sexy Star took him on with Chavo Guerrero Jr.. Havok, who some wrestling might have known better as Matt Cross, in turn teamed up with fellow Tough Enough contestant Ivelisse Vélez.
- Catherine Tate and David Tennant of Doctor Who fame were reunited for an onstage production of William Shakespeare's Much Ado About Nothing. They are both prominently featured in its advertising. (The two are also close friends in real life.)
- Camelot was written and originally produced by much of the same team responsible for My Fair Lady (including director Moss Hart in the last Broadway show of his life). Not only did Julie Andrews have the starring role in both productions, but Robert Coote, who was Pickering in My Fair Lady, returned as Sir Pellinore in Camelot.
- In the Mass Effect series Female Shepard and Ashley Williams are voiced by Jennifer Hale and Kimberly Brooks. The two have worked together as partners before... specifically band-mates Thorn and Luna from the various Scooby-Doo movies and shows. This makes it funnier if you have a female Shepard and always include Ashley in your squad and then turn the Hex Girls song on while playing.
- Batman: The Brave and the Bold:
- Blue Beetle (Will Friedle)'s best friend Paco is played by Jason Marsden, who previously played Eric Matthews (also Friedle)' best friend, er, Jason Marsden on Boy Meets World. The two actors are best friends in Real Life, so this sort of thing happens a lot with them.
- Kevin Conroy, the voice of Batman in the DC Animated Universe, played the Phantom Stranger in "Chill of the Night!" alongside Mark Hamill, who famously played the Joker in the DCAU as well, as the Spectre. The episode also featured Adam West and Julie Newmar (Batman and Catwoman from the 1966 series) as Thomas and Martha Wayne.
- "The Super-Batman of Planet X!" also featured Kevin Conroy as the Batman of Planet Zur-En-Ar. Since he's a Composite Character of Batman and Superman, his extended cast includes expies of Lois Lane and Lex Luthor voiced by Dana Delany and Clancy Brown, who played those roles in both Superman: The Animated Series and Justice League alongside Conroy as the Dark Knight.
- The Batman: "A Matter of Family", the episode that introduced Robin, featured Kevin Conroy (Batman from the DCAU) as Dick Grayson's father and Mark Hamill (Joker in also the DCAU) as Tony Zucco. That same episode also included Grey DeLisle as Dick Grayson's mother. Hamill and DeLisle voiced father and daughter Ozai and Azula on Avatar: The Last Airbender.
- When Pleakley's family comes to visit on Lilo & Stitch: The Series, they are voiced by many of Kevin MacDonald's former castmates from The Kids in the Hall. The only Kid in the Hall who didn't voice a family member voiced a preacher in that episode.
- In the sequels to Disney's Cinderella, Prince Charming is voiced by Christopher Daniel Barnes and Cinderella herself is voiced by Jennifer Hale. The two of them were previously the voices of Spider-Man and Black Cat respectively in Spider-Man: The Animated Series.
- Also, during the run of said series, Robert Hays reprised his role of Iron Man for some team-ups with Spider-Man. Hays and Barnes previously appeared together on the Starman TV series and both were reportedly thrilled with working together again.
- Tara Strong and Cree Summer have been friends since childhood, even growing up together, and these days do a lot of voice-over work together. In other words, if you hear one of them in a given series, you're likely to hear the other in the same series at some point.
- They've done enough shows together that their respective characters eventually parodied the infamous Sweeps Week Lesbian Kiss.
- A lot of cartoon voice actors do this with people like Tara and Cree, as well as Grey DeLisle, Tom Kenny, Kevin Michael Richardson, Rob Paulsen, Carlos Alazraqui, the list could go on.
- In The Simpsons, Sideshow Bob is played by Kelsey Grammer. His brother and father are played by David Hyde Pierce and John Mahoney respectively, who played Frasier's brother and father.
- After they both starred on The Suite Life of Zack & Cody, Brenda Song played a rival to Ashley Tisdale's Candace on Phineas and Ferb.
- Thomas Sangster played a young boy with a Precocious Crush on Olivia Olsen's character in Love Actually—so when they were cast as Ferb and Vanessa respectively, Ferb's crush on Vanessa became a Running Gag.
- One episode of Clifford the Big Red Dog had T-Bone (voiced by Kel Mitchell) meeting an old friend, Hamburger (Played by Kenan Thompson). If you're old enough, you'd remember that both of them starred together in two shows prior to breaking up due to creative differences.
- The Avengers: Earth's Mightiest Heroes: David Kaufman, known among other things for being the voice of Danny Phantom, showed up in "The Private War of Doctor Doom", reprising his role of the Human Torch from past Marvel video games. Regular series heroine the Wasp is voiced by Colleen O'Shaughnessey, who voiced Danny's sister Jazz Fenton. Reportedly, the two were excited to be working together again.
- In Avatar: The Last Airbender, Grey DeLisle voices Azula, and Mark Hamill voices her father, Fire Lord Ozai. In a third season episode of Danny Phantom, the ghost of the week, Undergrowth, is voiced by Mark Hamill, and Sam Manson is voiced by Grey DeLisle. When Undergrowth takes control of Sam's mind, she even calls him "father".
- In The Mighty B!, Andy Richter voices Amy Poehler's little brother. On Late Night with Conan O'Brien, Poehler played Richter's little sister in a few sketches in the late 90s.
- In the Adventure Time episode "Everything's Jake", the character Jake is trapped in his own body and meets a guy called Goose. Although Jake has never seen Goose before, Goose claims that Jake is an old friend. This is because Goose's voice actor, Billy West, and Jake's voice actor, John DiMaggio, voiced the main characters Fry and Bender in Futurama.
- In Steven Universe, Greg Universe and his former manager, Marty, are voiced by Tom Scharpling and Jon Wurster of radio show-turned-podcast The Best Show. Compounding the Casting Gag is that despite the real-life duo being great friends and well-known comedy performers, Marty was such an utterly despicable black hole of a person (similar to awful characters Wurster used to play on WFMU, like the Gorch or Timmy von Trimble) and abused Greg so badly that Greg now considers him "dead to me", even though he was indirectly responsible for Greg meeting Rose.
- Sharpling and Wurster reprise this shtick in an episode of Adventure Time, with Sharpling as Jake's brother Jermaine and Wurster as an evil demon Jermaine has trapped.
- In DuckTales (2017), arch-enemies Scrooge McDuck and Magica DeSpell are played by David Tennant and Catherine Tate respectively. Tennant and Tate were, you may remember, the Tenth Doctor and his best friend Donna Noble respectively on Doctor Who.
- In The Magic School Bus, several guest stars were friends of Lily Tomlin (Miss Frizzle), most notably Dolly Parton, her 9 to 5 co-star, who appeared as Miss Frizzle's cousin Katrina Eloise "Murph" Murphy in the "Holiday Special" episode.