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You can try. But you'll never catch me.
Dr Sheldon Cooper, The Einstein Approximation

As a Moments subpage, all spoilers are unmarked as per policy. You Have Been Warned.

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    Season One 
  • In the first episode, the boys are taking Penny out to a restaurant. Howard starts singing karaoke, and Sheldon observes to Leonard that compared to the others in the car (himself, at this point pretty much asexual; Raj, who can't talk to women, and Howard), he's "a veritable MacDaddy."
  • The Sarcasm Sign.
  • Raj's long, slow hallway walk after trying to ask out Sheldon's sister.
  • In "The Dumpling Paradox," Penny spends the night on Sheldon and Leonard's apartment after her friend hooks up with Howard in her apartment. After the sleeping arrangements are made, everyone goes off to bed, turning off the lights as they do. Cut to Raj, standing alone in the kitchen holding a half eaten sandwich and looking utterly confused before he awkwardly leaves.
  • How about the whole low register skit in the second episode when Sheldon breaks into Penny's room at night to clean it?
  • Penny's reaction to seeing her apartment clean.
    Penny: SON OF A BITCH!
    Leonard: Penny's up.
    Leonard: How did she know that it was us?
    Sheldon: I may have left a suggested organizational schematic for her bedroom closet.
    Penny: LEONARD!
    Leonard: God! This is gonna be bad!
  • The whole time machine acting-out segment.
    • In the same episode, at the end, Sheldon's Dream Within a Dream in which he uses the time machine to travel to the future and gets eaten by Morlocks starts out as Nightmare Fuel, but quickly Crosses the Line Twice when he tells Leonard he needs to move it out. The moving company workers turn out to be Morlocks.
    • 'Starving Morlocks' moving company. They have jumpsuits.
  • Leonard hearing a noise and coming out of his bedroom with a lightsaber.
  • The end of the Physics Bowl. "Here, I am janitor. In former Soviet Union, I am physicist. Leningrad Politeknika. Go Polar Bears."
  • Sheldon's reaction when, after he gets fired from work, Leonard calls his mother to snap him out of his obsessive funk. Watching him mouth the words "YOU CALLED MY MOTHER?" silently with a very offended look on his face is priceless.
  • When Leonard, Sheldon, Howard, and Raj all end up almost going as The Flash. And the series of "Oh no!"-s during said scene.
    Leonard: I call Frodo!
    Everyone else: Damn!
    • Raj's suggestion that they all go as The Flash, but standing one behind another so it "looks like we're one guy going really fast".
    • "He's a hobbit! I got your back, Leonard."
  • Sheldon: "Ah gravity, thou art a heartless bitch."
  • One of Leonard and Sheldon's first meetings with Penny:
    Leonard (staring after Penny after she's left): "Our children will be smart and beautiful."
    Sheldon: "Not to mention imaginary."
    • Which becomes a Brick Joke all the way at the end of the series.
  • The Chinese Dopplegangers of Sheldon and Leonard at the end of "The Cooper-Hofstadter Polarization".
  • Howard and his mom are awakened by an early morning phone call:
    Howard’s Mother: Well, who’s calling at this ungodly hour?
    Howard: I don’t know.
    Howard’s Mother: Well, ask them why they’re calling at this ungodly hour.
    Howard: How can I ask them when I’m TALKING TO YOU?!
    • It turns out to be Sheldon, so Howard pretends to be his mother, complete with voice.
    Howard: Why are you calling at this ungodly hour?
    Sheldon: I need soup.
    Howard: Then call your own mother!
  • This demonstration of Sheldon's Sesquipedalian Loquaciousness from "The Bat Jar Conjecture":
    Sheldon: Yes, well, I'm polymerized tree sap and you're an inorganic adhesive, so whatever verbal projectile you launch in my direction is reflected off of me, returns on its original trajectory, and adheres to you.
  • Sheldon delivers a hilarious Two-Faced Aside in "The Jerusalem Duality" after Dennis Kim calls his research a "dead end" and Dr. Gablehauser tells him to show Kim around the university:
    Sheldon: You can count on us! We're on it! [to Kim] What the hell do you mean, "dead end"?!
  • Sheldon's hilarious Mandarin.
    Sheldon:(In Mandarin) Show me your mucus! Your mucus!
    Chinese Man:(In Mandarin) Blow your own nose and go away!
    Sheldon:(In Mandarin) This is not a tangerine bicycle.
    Chinese Man:(In English) Crazy man. Call the police.
    Sheldon:(In Mandarin) No! Don’t call the library! Show me your mucus. (Leonard and Penny are seen entering, and then leaving again quickly.) Oxen are in my bed! Many, many oxen! Oy Vey!
  • Raj gets a call from an Indian woman whom his parents are trying to set him up with, but as we all know, Raj can't talk to girls. Howard's solution? Take Raj's phone, call her back, do an overblown imitation of Raj's Indian accent, and set up a date! It works!

    Season Two 
  • In one episode, Leonard comes back from a date with Penny and discovers that Howard and Raj were watching him say goodbye to her on a surveillance camera, which leads to this:
    Leonard: Sheldon, how could you sit there and let them watch my date with Penny?
    Sheldon: They're clever, Leonard. They took advantage of my complete lack of interest in what they were doing.
  • "I possess the DNA of Leonard Nimoy?! I can GROW MY OWN LEONARD NIMOY?!?"
  • Penny uses a very geeky simile:
    Penny: Leonard and Howard and Raj aren't like other guys. They're special. How can I explain this? They don't know how to use their shields.
    Alicia: Their shields?
    Penny: Like in Star Trek, when you go into battle, you raise the shields. (stunned pause as she realized what she said) Where the hell did that come from?
  • Sheldon's attempt at trash talk:
    I am given to understand that your mother is overweight. (Pause) Of course, if this is due to some glandular problem, rather than overeating and sloth, then I retract my statement.
  • "It's hot in here. Must be Summer."
    • Later, Howard's Epic Fail at trying to ask her out.
  • Sheldon high on Valium. Too funny for words!
    Sheldon: "Penny told me a secret, but I'm not supposed to tell you."
    Leonard: "What's the secret?"
    Sheldon: "Mom smokes in the car. Jesus is okay with it, but we can't tell Dad."
    Leonard: "Not that secret! The other secret!"
    Sheldon: *deep voice* "I'M BATMAN!"
  • Sheldon and Stuart arguing over Gradations of wrongness.
    Sheldon: I am asserting in the event that Batman's death proves permanent, the original Robin, Dick Grayson, is the logical successor to the Bat cowl.
    Sheldon: More wrong? Wrong is an absolute state and not subject to gradation.
    Stuart: Of course it is. It's a little wrong to say a tomato is a vegetable, it's very wrong to say it's a suspension bridge.
    • Particularly notable because so few people ever catch Sheldon in a logical fallacy.
  • Sheldon accidentally gets a date.
  • "We're here to see Koothrappali, not kill Batman!"
  • Sheldon's money is hidden in the hollowed out buttocks of an action figure, whose identity will remain secret for his own protection.
    • But if you ever find yourself short, there's always a couple of twenties in Green Lantern's ass.
  • The first episode with Leonard's mother, Raj and Howard were teasing Leonard about all sorts of childhood issues. Leonard got back at them by directing his mother's psychoanalyst nature at them. Her conclusion of Raj and Howard being in an "Ersatz Homosexual Relationship" leaves the two almost catatonically stunned silent (Raj even more so) and Leonard's victorious smile/Troll face just making the scene.
  • Space toilet + Mrs. Wolowitz's meat loaf
  • Penny screwing with Sheldon as he does his knocking routine in the season finale:
    Sheldon: *knock knock knock* Penny?
    Penny: *knock knock knock* Sheldon?
    *Sheldon looks puzzled*
    Sheldon: *knock knock knock* Penny?
    Penny: *knock knock knock* Sheldon?
    • This goes back and forth, faster and faster each time, culminating in Penny finally opening the door wearing a mischievous smile on her face.
  • "Sure, why not! And after the sun's down, we can all pile in my pick-up and go skinny-dippin' down at the crick. 'Cause today's the day to STOP MAKING SENSE!"
  • "Here, drink-slash-eat this [a stick of butter in a cup of hot cocoa]."
  • Sheldon trying out a driving simulator.
    Leonard: Awww...The pet store?
    Sheldon: Remind me to compliment Wolowitz on the software, it's amazingly detailed.
  • "The Ballad of Leonard Hofstadter", sung by Sheldon, after Leonard gets Penny's ex, Kurt, to pay back the money he owes her.
    Sheldon: *Sings* There once was a brave lad named Leonard, with a fi-fi-fiddle-dee-dee. He faced a fearsome giant, while Raj just wanted to pee.
    • Earlier, Leonard told the guys, who were terrified of coming with him, "You can go if you want, but I'm staying!" Cue the other three turning around and walking out.
    Leonard: Okay, I guess I asked for that.
  • One of the rare occasions where an incredibly funny moment is also a Tear Jerker: After Leonard reveals he built a hugging machine to use on himself as a kid, due to his mother giving him no affection at all, he also notes his dad used to borrow it very often.
  • Penny accidentally shoots Sheldon's "spot" on the couch with a paintball gun... after attempts to clean it up go wrong, Penny tries to solve the problem by turning the cushion over. Leonard notes there's no "butt-print" so Penny sits in the spot. In a great bit of Comically Missing the Point:
    Leonard: It's too small and too... perfect.
    Penny (grinning): ... THANK YOU!
    Leonard (also grinning): You're welcome...
  • The response by Leonard (and later the other three guys) when asked if he remembers Kurt (Penny's ex-boyfriend): Holding a hand way above his head to indicate how big he is.
  • Secret agent laser obstacle chess! It Makes Sense in Context. Well, as much as anything in this show makes sense.
  • Leonard telling Sheldon that "[Starfleet] General Order 104 Section A does not apply in this situation" because "THIS IS NOT STAR TREK!"
  • Sheldon high as a kite after just a few cups of coffee.
    Penny: We should've let him go to bed.
    Leonard: Bam.
  • In the blooper reel for the season, Leonard screws up the word "prepared" about five or six times in a row.

    Season Three 
  • Leonard gives Penny a preserved snowflake from the North Pole.
    Leonard: It'll last forever. I preserved it in a one percent solution of polyvinyl acetal resin...
    Penny: Oh, my God. That's the most romantic thing anyone's ever said to me that I didn't understand!
  • Raj and Sheldon's... offbeat montage.
  • Pretty much the entirety of "The Adhesive Duck Deficiency", but a couple highlights:
    • Leonard, Raj, and Howard high. Especially the end where Leonard and Raj are rolling on the ground laughing at Howard's expense over an embarrassing story he reveals to them. Also, Raj trying to slow down the Earth. With his mind.
    • Sheldon accidentally getting to second base with Penny.
      Penny: Is that my arm?
      Sheldon: It doesn't feel like an arm...
      Penny: Then maybe you should let it go...
      Sheldon (doing so): All righty.
    • Sheldon attempting to be "normal" and comfort Penny. "There there... Sheldon's here."
  • The whole episode "The Bozeman Reaction", too.
  • Two Words: Ballpit Bazinga!! Made even funnier by the fact that Jim Parsons is totally cracking up at the end.
  • Leonard's explanation for having to go out: Sheldon has broken out and is frightening the villagers.
  • Sheldon appears on NPR to explain magnetic monopoles, while Kripke fills his office with helium. Later on, Sheldon is sulking in his bed while Leonard tries to plant an idea of revenge.
    Leonard: Are you really admitting defeat?
    Sheldon: I never admit defeat.
    Leonard: Good.
    Sheldon: However, on a completely unrelated topic, I am never getting out of this bed again.
  • Sheldon's drunken stand-up act
  • In "The Gorilla Experiment":
    • Sheldon and Raj playing Mario Kart Wii.
      Raj: Ha-ha! Eat my dust, racially stereotypical plumber! (The race ends and Raj wins.)
      Sheldon: That's not fair! I got stuck behind a tree.
      Raj: And a cow, and a penguin. Face it, dude, whether it's a real car or a virtual cartoon car, you can't drive.
      Sheldon: I just need a little more practice.
      Raj: What you need is cheat codes, motor skills, and a magic genie who grants wishes to little boys who suck at Mario Kart.
    • Sheldon tries to teach Penny physics, but ends up only confusing her (Penny is revealed to have never taken a science class before). At last, a very confused Penny breaks down in tears, resulting in this exchange:
      Sheldon: "Why are you crying?"
      Penny: (exasperated) ''BECAUSE I'M STUPID!"
      Sheldon: "Well, that's no reason to cry. One cries because one is sad. For example, I cry because others are stupid and it makes me sad."
  • Raj in a bad mood:
    Leonard: "I've always been a little confused about this... why don't Hindus eat beef?"
    Raj: "We believe cows are gods."
    Sheldon: "Not technically. In Hinduism, cattle are thought to be like gods."
    Raj: "Do not tell me about my own culture, Sheldon! In the mood I'm in, I'll take you out, I swear to cow!"
  • Sheldon gets a summons due to a traffic fine he got helping Penny out when she dislocated her shoulder in the shower, Sheldon denies any wrongdoing, meanwhile, Raj has been wearing a sound effect t-Shirt and playing sound effects the whole episode.
    Sheldon: I'm not going to pay a fine, that would imply I'm guilty!
    Howard: But you are guilty.
    *Raj plays the Law & Order "Dun Dun" sound effect, which everyone laughs at*
    Howard: That one I liked.
  • I abandoned my goal to master Tuvan throat singing!
  • Spock's body with Mr. T's head.
    Leonard: Here's Spock's head with no body. Here's Mr. T's body with no head. Ah, here it is, Spock's body with Mr. T's head! "I pity the fool who's illogical!"
  • Stuart's crowning moment of sadness describing the 'big night' he has planned- sharing a tin of tuna with a cat he doesn't own that may or may not stand him up.
  • Sheldon's attempt at trash-talking along with Stuart's deadpan reaction:
    Sheldon: You bowl like your mama. Unless, of course, she bowls well. In which case, you bowl nothing like her.
    Stuart: Oh. Ouch.
  • Leonard's over-the-top double-take reaction to Sheldon's "I never get my way" comment in "The Precious Fragmentation".
  • Penny shrieking and whacking Sheldon right in the nose after he tries to steal the One Ring from around her neck while she's asleep.
    Leonard: What was that?
    Penny: Sheldon tried to take the Ring and I punched him.
    Leonard: That's my girl.
  • Sheldon has an unintentionally unfortunate name for his team in "The Pants Alternative":
    Penny: So what do you say Sheldon, are we your X-Men?
    Sheldon: No. The X-men were named for the "X" in Charles Xavier. Since I am Sheldon Cooper, you will be my C-Men.
    [Sheldon leaves the couch, while Penny and Leonard are horrified by his naming choice.]
    Howard: Oh, that's not a good name.
  • In the flashback to when Sheldon and Leonard first become roommates, Sheldon reveals that the apartment has a flag, which should never be turned upside down, unless the apartment is in distress. Later, when Leonard's rocket fuel experiment goes horribly wrong, the guys are freaking out and rushing to get it out of the building before it explodes, and Sheldon calmly turns the flag upside down.

    Season Four 
  • The entirety of "The Robotic Manipulation".
    Raj: You slipped and fell into a robot hand?
    Howard: Yes.
    Raj: Penis first?
    Howard: Yes, now help me!
    Leonard: I'd suggest a lubricant, but I have a feeling you fell on some of that as well.
    Nurse: What is this ?
    Howard: It's a robot arm.
    Nurse: ... Where's the rest of the robot?
    Howard: I only built the arm.
    Nurse: (smirks) 'Cause that's all you needed, right?
    Howard: Can you please just help me?!
    Nurse: Alright, alright, hang on, stay calm... (loudly over the intercom) I need an orderly with a wheelchair, I've got a robot hand grasping a man's penis out here.
    Howard: Do you think you could be a little more discreet?
    Nurse: I'm sorry. We don't have a code for "robot hand grasping a man's penis."
  • Howard trolling Raj:
    Penny: How does (Raj) know I jog?
    Howard: Oh, he watches you from his car with high-powered binoculars.
    (Raj's eyes widen)
    Penny: Oh, my God! That is so creepy!
    Howard: I KNOW!
    (Raj whispers in Howard's ear)
    (Raj's eyes widen again and he whispers in Howard's ear again)
    Howard: (to Raj) Then see a shrink and figure out how to talk to women!
  • Howard's mood-setting preliminaries to A Date with Rosie Palms in 'The Hot Troll Deviation' including easy listening music, fancy footwork and ambient lighting (courtesy of crossed lightsabers hung above his bed).
  • The entire exchange between Raj and Sheldon regarding the giant desk.
    Sheldon: Its size is completely disproportionate to its purpose!
    Raj: Given that its purpose was to piss you off, I'd say it's spot on!
  • Howard trying to decide which attitude to play when he sees Bernadette for the first time since they broke up.
    Howard: Wow, how am I gonna play this? Sophisticated and relaxed? Friendly and noncomittal? Cold and distant?
    [Bernadette turns around; Howard dives under the table]
    Sheldon: [looking under the table] I see you decided to go with "pathetic and frightened".
    Raj: It's one of his best moves.
  • A classic instance of Sheldon's Never My Fault attitude when Leonard complains of Amy's constant presence. It's Leonard's reaction that sells it.
    Sheldon: Are you suggesting I terminate my relationship with Amy?
    Leonard: No, no! Of course not, just have your relationship someplace else.
    Sheldon: May I point out that for 8 long months, I suffered in silence as your female companion note  filled our apartment with her off-key country music caterwauling, the unappetising spectacle of her grinding a pumice stone against her calloused feet in our living room, and night after night of uninformative TV documentaries about the Jersey Shore.
    Sheldon: Yes. And I'd thank you to do the same. (enters the apartment)
    Leonard: ... Really-SILENCE?!
  • Sheldon's reaction to Amy asking him to meet her mother: he politely says he'd love to, turns off the webcam... and then runs down the stairs in a wild panic calling for Leonard to help him.
  • Leonard invokes the Girlfriend Pact with Howard and says he wants a woman in his life like what Howard has. Howard's mother is off screen on the toilet and talking loudly about how much liquid is pouring out of her. Leonard quickly points out he meant Bernadette, not Howard's mother.
  • Sheldon's 25 cats!
  • Sheldon and Amy pretending to be in a actual relationship on a video call with Amy's mother.
    • "Time to make love to your daughter's vagina."
  • Sheldon and Amy's experiment on memetics throughout "The Herb Garden Germination", where in reaction to gossip of impending break up between Howard and Bernadette led to them getting engaged ended that scene with this particular gem:
    Sheldon: Perhaps your talk of my sexual prowess renewed her faith in love.
    • Emphasis on the fact that it's SHELDON saying that.
    • The way Amy tries to spread rumors.
      Amy: Sheldon and I engaged in sexual intercourse, in other news, I'm starting an herb garden, mum's the word, gotta go! *leaves*
    • This exchange;
    Amy: I described your love-making as aloof, but effective.
    Sheldon: Oh, I wish you hadn't have done that... It'll make me a Chick Magnet and I'm busy enough as it is.
    • Plus this little gem between Penny and a completely plastered Raj:
      Penny: Sheldon and Amy had sex!
      Raj: Shut. Your. Ass!
    • And a moment later.
      Raj: Did they know that's what they were doing when they were doing it?
    • The ending.
      Amy: (at Penny's door) I'm carrying Sheldon's child, mum's the word, bye!
      (she walks down the stairs, and bumps into Leonard at the bottom, who has his cell phone in hand)
      Leonard: YOU'RE PREGNANT?!
  • "Sometimes your movements are so lifelike, I forget you're not a real boy."
  • Oh, the Humanities!
    • "Sex criminals don't have keys, Ma!"
  • "The Toast Derivation" revealed that Sheldon once got punched by Bill Gates for saying: "Maybe if you weren't so distracted by sick children in Africa, you could have put a little more thought into Windows Vista."
  • Pretty much all of the Sheldon storyline with his group of new friends consisting of Barry Kripke, Zac and Stuart starting with their introductions 'Hello, my name's Stuart and what I'm most hoping to get out of this evening is a hot shower', a duet by Zac and Kripke of 'Don't go bweaking my heawt' and culminating with them plus Stuart (in a towel) singing "Walking on sunshine"note .
  • Sheldon's Imagine Spot where after Leonard asks if he can change the temperature settings on the thermostat, Sheldon imagines himself as The Flash, running to the Grand Canyon, screaming and running back to Pasadena.
    • From that same episode (The Justice League Recombination) Sheldon's variation on his usual "knock knock knock Penny" bit. "I'm the Flash, I just knocked thirty-thousand times."
    • And Howard's Batman voice, especially when Penny punches him in the arm.
      Howard: [whiny] Ow! ... I mean, [Batman voice] Ow.
    • Raj's Aquaman costume complete with integral seahorse- 'I've said it before... Aquaman sucks!'
    • When Penny says she won't go, Zack says he won't go without her, so Sheldon proposes switching to their Muppet Babies costumes. Raj calls Kermit, but Sheldon disagrees.
      Sheldon: I'm Kermit. You're Scooter.
      Raj: Aw, Scooter sucks! He's the Aquaman of Muppet Babies.
  • In "The Agreement Dissection," Amy (drunkenly) offers to have her pet monkey assassinate Priya for Sheldon:
    "If I can train a monkey to smoke, I can sure as Hell train him to shoot a poison blowdart, and no jury would convict us because PEOPLE LOVE MONKEYS!"
  • In the fourth season finale, Penny finds herself waking up in the morning in the same bed as Raj. Freaked out she insists that they completely forget that anything happened. Raj nods silently in agreement, having sobered up since last night. Penny asks incredulously "Really... still can't talk to me?!"
  • Any time Leonard's mom shows up. Especially when she mentions Howard and Raj's "latent homosexual tendencies".
    • When Sheldon thinks that Amy wants to take their relationship to the next level, he changes his and Leonard's address:
      Sheldon: Oh, I explained my predicament to our letter-carrier. His exact words were "I gotcher back, Jack. Bitches be crazy."
  • In the fourth season finale, when Raj is Sheldon's temporary roommate:
    Penny: What happened to Leonard?
    Sheldon: The same thing that happened to Homo erectus: he was replaced by a superior model.
  • "Forbidded it?"
    • "Forbodded it?"
    • "The word is forbade."
      • "Are you sure? That doesn't sound right."
  • "I think that's your cue."
    • "Oh... That bitch!"
    • From the same episode, same scene: "I don't have an urge to fling my waste."
    • Then later: "Amy was right, I do feel the urge to fling my poop at her."
  • When Penny and Priya are finished with the longest, most awkward stair-climb ever, Priya goes into Leonard's apartment and Penny, unlocking her door looks back and says, "Amy was right. I do wanna fling my poo at her".
  • The second-to-last scene of "The Love Car Displacement": The episode had been full of growing tension between the characters and it all comes to a head in a Q&A panel at which the scientists in the group (and their friend Howard) are giving a presentation, with Penny in the audience. The scene is here. note  The doesn't go so well.
  • The Howard/Raj accidental kiss.
  • Sheldon's emotional breakdown when he's learning how to act from Penny. Penny's first response is to call his mother and say "I think I broke your son." and puts Sheldon on the phone.
    Sheldon: Mommy, I love you! Don't let Spock take me to the future!
  • Penny's reaction to a disheveled Leonard returning home in "The Benefactor Factor": She gives him a knowing smile, greets him with "Good morning, slut", and confirms that she knows the "walk of shame" when she sees it...
    • At the end of the episode, the whole cafeteria gives an embarrassed Leonard a standing ovation...and as the scene fades out, you hear one last line:
    Howard: How was she?
  • In "The Desperation Emanation", Amy asks Sheldon to be presented to her mother as her boyfriend. Sheldon asks Leonard what to do. This leads to this exchange:
    Leonard: Let me see if I can explain your situation using physics. What would you be if you were attached to another object by an inclined plane wrapped helically around an axis?
    Sheldon: Screwed.
  • When Howard tells Leonard that he's getting back together with Bernadette:
    Howard: I think I’m gonna take her to miniature golf.
    Leonard: Ah. Well, I guess for you guys that’s like regular golf.
    Leonard(laughing): Yeah, and don’t you forget it.
  • Howard's mother in general. Gems include her explaining her inability to answer the door with the delightful information she's conducting a bowel cleanse and is "like an upside down volcano" ("Holy moly, how much liquid can be in one tuchus?!") and when Howard tells her he has some news... "I hope it's good news because I've got nothing but disappointment in here!"
  • In "The Boyfriend Complexity", the sheer amount of schadenfreude Leonard gets out of posing as Penny's boyfriend while her dad is visiting.
    Leonard: Hey, lovebug.
    Penny: Shut up. You know what I’ve been doing for the last hour?
    Leonard: Mm, dreamily doodling "Mrs. Leonard Hofstadter" in a notebook?
    Penny: Listening to my father go on and on about what a great guy you are.
    Leonard: (completely serious) Well you got to admit, I am, I’m delightful.
    Penny: Why are you making this so difficult?
    Leonard: It’s not difficult for me, I’m having fun!
  • Sheldon has been the butt of many practical jokes throughout the series but Howard's card trick prank was truly inspired. The crown jewel is undoubtedly bringing Penny in on it.
    Penny: Aww, he has the same look my little nephew gets when he can't figure out how I got his nose.
  • The gang revealing each others' betrayals in 'The Irish Pub Formulation'. Special mention goes to Howard sharing that Sheldon has been grinding insects into Leonard's food for the past month, but he insisted that it was an experiment to see when "food starts tasting mothy".
    Leonard: You put moths in my food?!
    Sheldon: For science.

    Season Five 
  • Two words: Internet Kissing
    • Leonard's "what the hell" expression as he watches sells it.
    • Leonard and Priya's attempt at web sex.
    Leonard: (hesistantly) Y-You're a naughty girl. And uh, I wanna punish you with my love...?
    Priya: What.
    Leonard: ... not good?
    Priya: That's terrible, try again.
    Leonard: Okay, uh... you're... not naughty. You-you-you're dirty. You're a... dirty girl?
    Priya: Ohh yes, yes I am.
    Leonard: Yeah yeah okay you're a ... dirty, disgusting, revolting girl! Bleeurrgh!
    Priya: God, Leonard, stop talking.
  • After Sheldon got himself purposely slaughtered in paintball due to his incompetence as a leader, it ended up inspiring the rest of his friends to take back the game. "If there is going to be a Church of Sheldon, this is where it began."
    • Made even better by exactly how he gets himself slaughtered. "Geology isn't a real science!"
  • Sheldon's "Look everyone! Wil Wheaton is my friend!" Followed shortly by "Brent Spiner, you are now my mortal enemy."
    Wil Wheaton: Don't worry. It doesn't take up a whole lot of your time.
  • Leonard's attempt at "prayer":
    Leonard: It's probably a little late to ask you to make me taller...
    • Penny gives him the most adorable little look after he says that.
  • In "The Good Guy Fluctuation", after being the victim of many pranks throughout the episode, Sheldon finally gets his payback on Leonard in a big way when he springs out of the couch in zombie makeup. Granted, playing a prank on your best friend about five seconds after he painfully breaks up with his girlfriend isn't so much a prank as a Kick the Dog moment.
    • From the same episode.
    Sheldon: It's me, Sheldon, Mrs. Wolowitz.
    Howard: That's not my mom. It's Bernadette.
    Sheldon: Really? That's very unsettling.
    • This is topped moments later when Sheldon, forgetting the Electric Joybuzzer he's wearing, performs a Face Palm after getting pranked again.
    Sheldon: Oh, how could I be so stuUuUuUuUuUuUuUuUuUuU- *falls over*
  • Sheldon's reaction to seeing the bluejay sitting in his spot in "The Ornithophobia Diffusion".
    Raj: That is one tough birdie.
    Penny: "Maybe she would like to know that half of your dirty movies... are animated!"
    • After Bernadette catches the bird, Sheldon tells her to carefully "flush it down the toilet".
  • Penny playing with Sheldon's OCD knock.
    Penny: Who do we love?!
    Sheldon: Penny.
    Penny: Who do we love?!
    Sheldon: Penny.
    Penny: Who do we love?!
    Sheldon: Penny.
  • Sheldon unveiling the Relationship Agreement to Amy, enumerating, iterating, and codifying the rights and responsibilities of Sheldon Lee Cooper (hereinafter known as "the boyfriend") and Amy Farrah Fowler (hereinafter known as "the girlfriend"). Not only is it completely in character for Sheldon, but Amy is visibly moved by the whole ordeal (Mayim Bialik hits just the right tone between deadpan and getting choked up).
    Amy: "It's so romantic!"
    Sheldon: "Mutual indemnification always is."
    • There's an extra layer in that scene, depending on when Sheldon drafted the Relationship Agreement. If he did it after getting confirmation from Amy to be his girlfriend, then he drafted a 31-page paper in the less than two hours, it's awesome. If he did it before he asked Amy, then he wanted her to be his girlfriend for quite some time, it's heartwarming.
  • Sheldon after a night of snuggling with Amy:
    Sheldon: (To Howard and Leonard) "The two of you need to get your women in line!"
    Leonard: "... what?"
    Sheldon: "Last night, I was strongarmed into a night of harp music and spooning with an emotional Amy Farrah Fowler. This on a night I had reserved for solving the space time geometry in higher spin gravity... and building my LEGO Death Star. And why? Because your gal pals, Penny and Bernadette, went shopping for some wedding nonsense without Amy. An action they took with no thought or regard as to how it would affect me, the future of string theory or my LEGO fun time!"
    Howard: "What do you want us to do about it?"
    Sheldon: "You clearly weren't listening to my topic sentence... get your women in line! You make them apologize to Amy and set things right. I am a man of science, not someone's snuggle bunny!"
    Leonard: "Why do I have to talk to Penny? She's not my girlfriend."
    Sheldon: "You invited her to lunch four years ago... everything about her is on you! You make it so!"
  • Amy freaking out over receiving a "tiara, tiara, tiara!" in "The Shiny Trinket Maneuver".
    Amy: Jewelry? Seriously? Sheldon, you are the most shallow, self-centered person I have ever met. Do you really think that another transparent manip- *pulls the tiara out of the bag* Ohhhhhh, it's a tiara! A tiara! I have a tiara! *Rushes to Penny* Put it on me. Put it on me. Put it on me. Put it on me. Put it on me. Put it on me. Put it on me.
    Penny: *places the tiara on Amy's head* You look beautiful!
    Amy: OF COURSE I DO! I'M A PRINCESS AND THIS IS MY TIARA! *grabs Sheldon's face and passionately kisses him, then hugs him*
    Sheldon: *to Penny, utterly serious* You're right, the tiara was too much.
    • From the same episode, Howard's magic show. Especially the exchanges between Bernadette and the kid who's not getting any cake.
  • Leonard showing up Sheldon in "The Friendship Contraction" when the power goes out and Sheldon suggests using glow sticks. Leonard takes out his full-size lightsaber, and tops it with a Crocodile Dundee Shout-Out.
    Leonard: You call that a glow stick? That's a glow stick.
  • From "The Rothman Disintegration":
    • Sheldon Cooper & Barry Kripke playing basketball against each other to decide who gets Professor Rothman's office.
    • Leonard, Raj and Howard while watching Sheldon and Barry play.
    Leonard: You know those terrible things bullies used to do to us?
    Raj: Yeah.
    Leonard: I get it.
    • From the same episode, Amy buys Penny a huge painting and at the end of the episode reveals a very uncomfortable secret about the already awkward gift.
    Amy: I'll let you in on a little secret. Originally, we were painted nude. But I had him add clothes cause I thought it was an unnecessary challenge to our heterosexuality.
    Penny: Yeah, good call.
    Amy: But, if you ever change your mind, all it would take is some warm, soapy water and a couple of sponges.
    Penny: You're talking about the painting, right?
    Amy: Sure.
  • Raj voicing his envy at his coupled friends, stating that
    Even if I get one [a girlfriend] someday, I'd still be the guy who got a girl after Sheldon Cooper!
    • And right after
    Penny: See, Amy, that's how a girl makes a scene.
  • "Bongo solo!"
    • Leonard's revenge for the Bongo solo.
    Leonard: Aww, he looks so peaceful. (Bangs on Bongos). SHELDON LIKE TO SLEEP WHILE LEONARD PLAY THE BONGOS!
    Amy: That was kind of uncalled for.
    Leonard: Nah, it was called for.
    • Or earlier:
    Sheldon (offscreen): I PLAY BONGOS, WALKIN' DOWN THE STAIRS!
    (CRASH, BANG, THUMP, WALLOP. Leonard and Penny look to each other in horror)
  • "Let me try gangsta. Hellz naw!"
  • The whip app.
    Leonard: (laughing) I was wrong, that's still funny.
  • The French Maid outfit.
    Sheldon: What, you've never seen a man try to get a meeting with Stephen Hawking before?!
    • Then, when he finally manages to get said meeting:
    Sheldon: Oh gosh golly, I made a boo-boo... and I gave it to Stephen Hawking. *faints*
    Stephen Hawking: *Beat* Oh great, another fainter.
    • Also, Bernadette's summation of Sheldon.
    Bernadette: He's only mean because that part of his brain that should know when he's being mean is getting a wedgie from the rest of his brain.
  • Leonard finally finds out about Sheldon seeing Penny naked after a few seasons of it going entirely unmentioned.
    Sheldon: Oh relax, it was only her bottom and her breast.
  • Evidently, Leonard's eyebrows are "stupid".
    • Raj's entire relationship with Siri, as well as Barry's attempt at using her, from the same episode.
    • Barry asking Siri to "wecommend a westauwant".
  • Bernadette shoots down Howard's dream.
    Boo, hoo. You're not going to space!
  • Penny's EPIC trolling of Leonard in "The Transporter Malfunction". She gets Sheldon a vintage Star Trek transporter toy and gets Leonard... a label maker. Leonard's obviously disappointed and tries to play it off ("Also mint-in-box!") before Penny reveals that she got him a transporter toy too. At that point, Leonard literally THROWS the label maker away as he grabs the box out of her hands. "AWESOME!"
  • Leonard takes Penny out to a shooting range. Things go awry.
    Leonard: *Meekly, as Penny helps him up the stairs* So I've got a gunshot wound... that's pretty badass...
    • Made funnier because Penny points out it's actually just his shoe that has the gunshot wound. He just has a small graze on his foot.
  • Bernadette's Heel Realization in the "Russian Rocket Reaction" that she betrayed Howard by telling his mother about him going to space;
    Bernadette: Oh god, I took our love and threw it under his bus-sized mother!
  • Leonard is not "some kind of nerd". He is the King of Nerds!
    Penny: What does that mean?
    Leonard: It means if anyone displeases me I don't help them set up their printer.
    • which is itself a callback to "The Dead Hooker Juxtaposition"
  • When Howard is about to go into space in the season finale.
    Mike Massimino: That's ignition. I LOVE THIS PART!
    Dimitri Rezinov: ME TOO!

    Season Six 
  • "GO SPORTS!"
  • "Oi. I can't believe these people won the Cold War."
  • The best description of Howard's mother ever.
    Dimitri: Wolowitz, you have a call.
    Howard: Who's it from?
    Dimitri: A woman who says she's your mother, but sounds like your father.
    • Her demanding to know why Howard hasn't send a postcard to her. From the International Space Station.
  • Howard slowly losing his mind in space.
    Howard: They left dogs up here in the Sixties!
  • This exchange:
    Bernadette: You think you'll ever get married someday?
    Amy: Not just someday. In exactly four years. But don't tell Sheldon, he's still a flight risk.
  • Raj, as mythic as ever:
  • Sheldon failing miserably at Pictionary.
  • Howard's miserable first day back, with his wife getting sick and conking out on him, and his friends having their own plans, is capped off by him sneezing just like Bernadette did, and him saying, "Perfect." It's the look on his face, the one that says, "I'm not even surprised. This is exactly how a day like this would end."
  • It may have been a dream but Santa's Christmas gift to Sheldon was hilarious, first he tells him to close his eyes.
    Sheldon: I hope it's trains.
    Santa: Oh it's better than a train.
    Sheldon: Two trains?
    Santa: Better.
    Sheldon: I'm getting three trains.
    Santa *While holding a flaming torch*: Okay! Open 'em!
    *Santa has a cannon pointing at Sheldon*
    Sheldon: Wait! Hey! Hang on, in my defense...
    Santa: Ho Ho Ho, you big dork! *Fires cannon*
  • Howard and Bernadette going to the Halloween party as Papa Smurf and Smurfette.
  • Sheldon's costume, introducing Raggedy C-3PO!
  • "What does Sheldon Cooper and a black hole have in common? They both suck. ... neener neener."
  • Sheldon gets a pretty new assistant Alex.
    Amy: Sheldon told me he had a new assistant named Alex. He didn't mention that Alex was a girl.
    Penny: *utterly deadpan* Maybe he didn't notice.
    Amy: You're right. I don't have to worry about Sheldon.
    Penny: *cracking up* No, you don't.
  • This bit:
    Amy: I feel like I'm in high school again.
    Bernadette: I know. Doing the prom queen's homework so she'll like me.
    Amy: (grinning gleefully) It's finally working!
  • Drunk Sheldon:
    Sheldon: (knock knock knock) Wil Wheaton! (knock knock knock) Wil Wheaton! (long pause) Wait, how many was that?
    • Also:
    Sheldon: I'll tell you (telling Wil Wheaton why he's at his house). I'm from Texas. Need I say more?
    • And:
    Sheldon: "As a matter of idle curiosity, which of your shrubberies do you feel would benefit from a thorough vomiting? Never mind, I’ll choose."
    • Later:
    Wil Wheaton: "Oh, Sheldon... do you really think we're gonna fight?"
    Sheldon: "My fists are not up here because I’m milking a giant invisible cow."
  • The fake video Sheldon makes to scare Raj and Howard when they spy on his private time.
    • The Reveal as to what Sheldon does in that storage room: Playing hackysack.
  • "... and they're all taller than me, WHY IS EVERYONE TALLER THAN ME?!?"
  • Bernadette trying to be romantic and sexy with Howard while horribly sick with a cold. (waking up from a 5 second Benadril nap) "Oh Howard, that was wonderful!" In addition, it was hilarious to hear the squeaky-voiced Bernadette so congested. Melissa Rauch is a gifted comedic actress and that was the first opportunity for her to really show her chops on the show.
    • "That was short and gross... now I know how she feels."
  • In "The Parking Spot Escalation", Amy and Bernadette's bickering over Sheldon vs. Howard's parking spot results in Amy accidentally breaking Penny's nose with her purse (which contains her wallet, keys and a coffee can full of change she intended to take to the bank)...
    Amy: (mortified) Penny, are you okay?!
    • they take her to the emergency room:
      Amy: Come on, I'll show you where the tow truck scratched my car.
      Bernadette: Oh, the tow truck couldn't have scratched it.
      Amy: How do you know that?
      Bernadette: 'CAUSE I DID IT!
    • The entire satellite war between Amy and Bernadette is incredible, but the absolute peak was:
      Bernadette: Gosh, Amy, I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?
      Amy: Well, at least when we do make love, Sheldon won't be thinking about his MOTHER! And yes, that's a cleverly veiled reference to Howard's lifelong obsession to crawl back into her spacious womb.
    • The great part is Penny is trying to keep the peace by changing the subject, but after the above exchange, all she can say is a dejected "damn."
      • Even better. Look carefully. Penny thinks Bernadette's "theoretical sex life" line is Actually Pretty Funny.
  • After finding out Amy's being feigning sick (so she could trick Sheldon into touching/bathing her), Sheldon suggests an old-school discipline: spanking Amy for lying to him. She turns on some R&B.
    (Sheldon lightly spanks her)
    Amy: Oh my!
    Sheldon: You're not supposed to be enjoying it!
    Amy: .... Well, maybe you should spank me harder!
    Sheldon: .... Maybe I will! *does so*
    Amy: Woo-hoo!
  • Penny teaching a very squeamish Howard how to gut a fish.
  • The absurdity of GIANT JENGA.
  • Stuart trying to help the girls in the comic book store and telling the other (male) customers in the store to stop staring ("It's nothing we haven't seen in movies and drawings!"):
    Stuart: Well, there's manga, comic books, graphic novels - I swear I will turn a hose on you!
    • He whirls around to snap at the guys and then turns back to the girls with a polite smile on his face, then reacts with horror when Amy asks which superhero is "best" - "You can't say that sort of thing in here! Do you wanna start a rumble?!"
  • Sheldon reprograms the GPS with his voice (and adds his usual little idiosyncrasies and factoids in as well). Howard's response? "Oh, look, Leonard, there's a bridge... Drive off it."
    • The Stinger at the end revealing the carjackers actually enjoy Sheldon's brain teasers.
  • Penny and the mimosas.
  • The entire subplot with the girls in "The Bakersfield Expedition". While the boys are away they read a couple comics to see what's so interesting about them, and come to the conclusion they're stupid. They then get into an argument about the exact meaning of only Thor being able to lift his hammer, and in their search for answers read the comics again then head into Leonard's apartment to start reading the comics there, all the while arguing semantics over what qualifies as "lifting" the hammer and how it's decided one is worthy of doing so. The arguments being tossed perfectly mirror the frequent jousting the boys got into in earlier seasons, and when they come home and hear what's going on, they're stunned by it.
    • "YOU DON'T KNOW HIS LIFE!" note 
    • This bit:
    Bernadette: Well, what if the Hulk picked up Thor while Thor is holding the hammer?
    Amy: Yeah...?
    Bernadette: Then by the transitive property of picking things up, Hulk picked up the hammer!
    Amy: No, Hulk picked up Thor, Thor picked up the hammer.
    Penny: Okay, hang on. If I go to a bar and pick up a guy, and he picks up a girl, and we all leave together, did I pick up the girl?
    Amy: (grinning) Did that ever happen?
    Penny: ... Hey, we talking about me or are we talking about Thor?
  • More from the above episode, after getting their car stolen the guys are walking across the desert road hot and miserable. Sheldon (dressed as Data) goes to give a Rousing Speech comparing their plight to the Star Trek crew exploring an unknown planet. Just when it seems like he's about to inspire them to move on a car drives by and a guy throws his smoothie out at him staining him and his outfit. His response? "I hate this planet!"
  • Penny absolutely spazzing out in The Cooper/Kripke Inversion when Sheldon admitted that he may consider a physical relationship with Amy at some point in the future.
  • Everything with Raj and Howard's mother in "The Spoiler Alert Segmentation." A few highlights:
    Howard: Dude, you have to leave now or you never will.
    Raj: Man, you're being paranoid.
    Howard: Oh yeah? Where are your clothes and shoes?
    Raj: There over there on the... (see his clothes are gone) chair.
    • Later on...
    Howard's mother: Rajesh, I drew you a bath.
    Raj: (to Howard on phone) She's not going to bathe me herself, is she?
    Howard: Gee, buddy, I really wish I could tell you no.
    • After Howard and Raj finish talking...
    Bernadette: Should we go back and try to help him?
    Howard: Too late now. We'll see him at his bar mitzvah.
  • Raj and Lucy's texting date at the library, a safe place they can talk and interact. It's a clever way for Raj to get around his mutism, but it manages some hysterical bits with the idea, including the autocorrect mistake that Lucy designs Porn websites vs. PROM websites.
    Raj: (via text) It would help you to remember that I have an adorable accent.
  • Raj asks Howard and Bernadette to take care of his dog while he's away. Cue standard sitcom plot of missing dog. Someone else finds the dog, Raj recovers it, and then takes Howard to task over the incident. Then Bernadette fires back at Raj, berating him for knowing that he had the dog "for hours" and didn't tell them. "Now go and think about what you did!", to which Howard replies, "I think you'd make an excellent mother!"
    • When Howard and Bernadette are looking for the dog, they try calling for her in an Indian accent. Leading to this exchange:
    Howard: Remember that for tonight. It's kind of a turn-on.
  • This bit:
    Sheldon: (keeping Leonard up) Nice to meet you, Professor Proton. Nice to meet you, Professor Proton.
    (Leonard leaves his room)
    Sheldon: Nice to meet you, Professor Proton. Nice to—(a slap is heard)—ow!
  • Also in the same episode, Professor Proton himself (Bob Newhart) when he meets Sheldon.
    Professor Proton: Is uh, is he dangerous?
    Leonard: Actually, he's a genius.
    Sheldon: I am.
    Professor Proton: That uh, that doesn't answer my question.
    • A few minutes later...
    Arthur: (about Penny) Is she really your girlfriend?
    Leonard: Yeah.
    Arthur: You're the genius.
  • Sheldon's childlike enthusiasm for Howard's celebrity impressions.
  • Raj finally being able to talk to women in the Season Finale. The girls, however, quickly wish he'd go back to being silent around them.
    Amy: Does he ever shut up?
    • And he continues talking even over the credits while you see Amy chug her wine.
  • Penny learns that Leonard is going to be working on a boat for a cutting-edge project headed by Stephen Hawking. Her first thought was to exclaim "Aren't they afraid he's going to roll off?" In a later scene talking with Sheldon, she made a point to add "Who, as I learned, will not actually be on the boat."
  • In "The Contractual Obligation Implementation", the girls decide to go to Disneyland where they can get princess makeovers. Bernadette insists she must be Cinderella because it's her idea and they are in her car.
    • Doubles as a Heartwarming AND Awesome moment for her when the end of the episode reveals she planned the trip because she knows Howard would like seeing her dressed as Cinderella (she says she has a surprise for him and he hopes her being dressed as Cinderella is the surprise).
    • Meanwhile, Amy and Penny dress as Snow White and Aurora, respectively. At the end, their respective boyfriends see them in costume. In Penny's case, as she explains to Leonard why she is dressed up, he responds by taking his pants off. As for Amy, she pretends to be asleep so that Sheldon will kiss her, but he isn't buying her act.
  • "You pulled the plug on my funk!"
  • In "The 43 Peculiarity" Leonard was getting jealous of Penny spending time with a male classmate, eventually trying to make guy think "Penny's Boyfriend" had gang connections. The classmate mentions he thought Penny was dating a scientist and Leonard says that's their gang name. Penny saw him doing this and was annoyed with his behavior. The next time they meet in the hallway she sarcastically says "Shouldn't you be out with your gang spray painting equations on the side of buildings?"
    • The argument lead to Penny saying "I love you" in exasperation, which made them freeze up as that was the first time she said it to him. He wonders if they are just going to ignore the weight of what she said, and while tearing up she says "That's exactly what we are going to do. Because you're about to make me cry and we both know if I start crying... you're going to start crying."
  • Amy gets her first bikini wax in "The Parking Spot Escalation" and is walking a little wobbly afterwards. The dialogue implies that they had to wax off a lot.
    Amy: Does it always take that long?
    Penny: No, they usually don't have to go out and get more wax.
    Amy: I feel like I'm five pounds lighter.
    Bernadette: Really? Only five?
    • And later she shows it to Sheldon.
      Sheldon: Boy, that's a lot of Band-Aids!

    Season Seven 
  • "Serial Ape-ist"!
  • Howard and Raj comparing Cup Sizes. Even better, when Bernadette walked in on it.
  • Howard and Amy discover a mutual love of Neil Diamond when they're paired up for a Scavenger Hunt. They proceed to spend the rest of the episode happily singing along to his songs.
    Amy: To the Neilmobile!
    • Also from that episode, Sheldon insists on bringing a bowling ball with him on the same Hunt just in case they end up in a bowling alley, to everyone's amusement (and his partner Penny's irritation). Take one guess where they end up going.
    Sheldon: Yes. Yes. My brain is better than everybody's!!!
  • Amy reveals to Sheldon that Indiana Jones is mostly irrelevant to his own story, causing Sheldon and later the rest of the guys some distress.
  • Amy wants to put Sheldon's habit for repetition to good use some day. Think about it.
  • Howard plans to surprise Bernadette on their anniversary, even when she ends up in the hospital beforehand. He writes and performs a song for her that is the sweetest, nerdiest and most romantic song ever written. These lines especially
    Howard: I'd speak a lot more Klingon, Heghlu'meH QaQ jajvam
    Everyone else: And he'd definitely still live with his mom.
    • What really sells it is the look on Penny's face as she sings the line. It's like "Not just a lyric. This would no doubt be true."
  • When Sheldon, clueless as ever, goes to Amy to tell her that she gets to drive him home, after he humiliated her at her first day at her new lab, Amy is showing pictures to a monkey, trying to get a response. Instead, as she does so, Sheldon and the monkey have the exact same reactions to the pictures.
  • Sheldon's method for developing a new, stable, super heavy element is the best thing since the Communist Party!
  • When Howard starts attending girl's night, Raj gets upset because he liked having a place where he wouldn't be judged for his lack of masculinity. Howard apologizes and they make up, but when they start drifting to Ho Yay, we get this:
    Amy: I knew it! They're gonna sleep together before Sheldon and I do!
  • Penny thinks Raj will be happy with her for confronting Lucy. Cut to Raj yelling "HOW COULD YOU DO THIS TO ME, PENNY?!" Seconds later, Lucy emails him to meet up, to which he responds, "I LOVE YOU, PENNY!!!"
  • Sheldon drunk in The Thanksgiving Decoupling. He insults Howard and Bernadette, bonds with Bernadette's father over football, and burps a Mouthful Of Pi. The best part has to be when Amy intercedes and makes Sheldon apologize:
    Bernadette: Hey. Howard says that you've been making fun of him all day. Now both of you apologize right now.
    Sheldon: She's so tiny! It's funny when she's mad.
    Amy: All right, mister. I think you owe Howard and Bernadette an apology.
    Sheldon: Perhaps you're right. I'm sorry for my behavior. I've had alcohol and it's caused me to be inappropriate.
    Bernadette: Okay.
    Howard: Don't worry about it.
    Amy: Thank you.
    Sheldon: Ain't she great?
    Amy: [embarrassed] Sheldon.
    Sheldon: Now, hows about you get us a couple of beers? [swats Amy on the rear]
    Howard & Bernadette: [stunned silence]
    Amy: [looks shocked and walks dazedly to the door, but then slowly breaks into an amazingly satisfied smile before leaving the room]
  • Sheldon's phone conversation with president Sievert, including a Call-Back to Season 3.
    Sheldon: I just want you to know I will be able to represent the university. I talked to my friend Wil Wheaton. (Beat) I'll have you know I have NINE friends; ten if I include you. (Beat) OK! Nine it is. (hangs up) Eh, 10. I'll bump up Wolowitz.
  • Sheldon, fed up with Barry's antics, decides to mock his rhotacism. Barry immediately turns depressed, forcing Sheldon to take it back... only for Barry to continue taunting him.
  • As the gang talk about how things would be different without Sheldon, Penny tells a story about how Leonard trying to ask her out would end with him peeing himself. Later he retaliates with a story about her and Dumb Muscle boyfriend Zack.
    Penny: Okay, he's not smart. At least he wouldn't have peed himself.
    Leonard: I wasn't done yet. [cut back to story]
    Zack: Aw, man! I peed myself!
    Penny: Me too!
  • The reactions to Sheldon's graphic e-mail photos of his sister giving birth.
    Penny: Come on. Childbirth is a natural... AAAGH! It's like someone sawed a cow in half!
    Raj: Please, my father's a gynecologist. I think I can handle it... And now I'm gay.
    • Sheldon's traumatized reactions to the birth. "I saw things. Lady things."
    Amy: Sheldon, listen to me. That is not the way they usually look.
  • Amy's exasperation with Sheldon's attempts to study and learn humor in "The Hesitation Ramification."
    Amy: Do you have any idea how hard it is to laugh at a knock-knock joke that starts, "Knock Knock Knock, Amy! Knock Knock Knock, Amy! Knock Knock Knock, Amy!"?
  • James Earl Jones says "This Leonard sounds like a real weenie." May also count as a Moment of Awesome since it is James Earl Jones saying it in his iconic voice.
    • That whole damn night was hilarious. Who knew James Earl Jones was such a party animal?
    James Earl Jones: Let me guess, you like Star Wars. You know, I've been in other movies. But you don't care about those, do you? I have one thing to say to people like you... I LIKE STAR WARS TOO!
    • Not to mention the two of them pulling a ding-dong-ditch on Carrie Fisher - and it's Jones' idea.
  • In "The Friendship Turbulence" Bernadette accidentally tricks Howard into inviting Sheldon along to visit NASA with him.
    Bernadette: This is gonna be a long weekend for you.
    Howard: You're the reason I'm doing it!
    Bernadette: I said to stop insulting each other! I didn't tell you to take him on a romantic getaway!
    Howard: How do I know what you said? Damn you and your noise-canceling breasts.
    Bernadette: *looks proud*
  • In "The Indecision Amalgamation" Bernadette writes a humorous message on what she thought was a "Congratulations on Retirement" card, but turned out to be a "Get Well Soon" card for a woman who was horribly injured in a car accident.
    • In the same episode, Amy and Sheldon are having dinner and Sheldon can't decide whether to get an Xbox One or a PlayStation 4 much to Amy's annoyance when she wants Sheldon to pass her the butter. Amy decides to fake interest in Sheldon's decision making and when he asks her what he should do she responds, while pounding on the tabletop, "PLEASE PASS THE BUTTER!"
  • Sheldon using tips from Cosmopolitan to "break up" with string theory in "The Relationship Diremption".
    • After getting drunk and being led into his room:
    Sheldon: [knock, knock, knock] Empty room. [knock, knock, knock] Empty room. [knock, knock, knock] Empty room. If someone answers, I'll freak out.
    • And the next morning, Sheldon wakes up in bed with... a geology book. Complete with walk of shame.
    • Sheldon's drunken messages to Stephen Hawking.
    • Not to mention Hawking's response.
    Stephen Hawking: What a jackass!
  • Penny's dismay upon realizing that she "gets" the guys' Star Wars references.
    Penny: WHY DO I KNOW THIS?!?
  • Amy and Bernadette make a Death Star cake for the guys. Bernadette asks why people don't make more spherical cakes, and right on cue the cake rolls over the table and onto the floor.
    • Later, when they bring the cake over to the guys, Bernadette expresses regret at having missed the movies, only for Howard to mention that they started over because of Sheldon.
    Bernadette: (whispers to Amy) Son of a bitch!
  • From "The Proton Transmogrification". Sheldon is watching an episode of Professor Proton:
    "Here's a fun fact: after owls eat, they spit out the parts of their food that they can't digest, in the form of a pellet. Isn't that a hoot? We'll be right back after I fire my writers."

    Season Eight 
  • Sheldon asks Amy to cover her ears for a moment so he can speak in private to Leonard on their drive home. As soon as she does, Sheldon turns to Leonard and says, "I plan to have coitus with Amy as soon as we get home." Leonard and the audience have to collectively pick up their fallen jaws just in time to realize that Sheldon was merely ascertaining whether or not Amy could hear him. It drifts into Heartwarming Moments territory from there.
  • Penny has just fumbled her job interview quite badly, and she knows it. She asks her would-be boss not to tell Bernadette how badly she did, because Bernie tried so hard to get her this interview... and Penny's kind of scared of her. The interviewer looks at Penny incredulously, "Bernadette scares you?" Penny confirms. Then we get:
    Interviewer: Me too!
    • He then proceeds to tell Penny that he was supposed to tell Bernadette that they were cutting funding for a drug she was working on. When Penny asks how that went, there's a Beat, and then he informs Penny that they're still working on the drug.
    • In a later episode, it turns out the entire company is scared of her, even the boss.
    Boss: Well, there's been something I've been wanting to tell you... the company won't be paying for free coffee anymore.
    Bernadette: Okay... when is this happening?
    Boss: Five months ago.
    Bernadette: Then who's been paying for the coffee?
    Penny: We all do. We use the money from the swear jar. We put a little in every time you use a swear word.
  • Howard manages to shoot a spit-ball into Sheldon's mouth.
    Howard: Is that going to be on the test? Because I don't think I can do it again.
    • The funny continues as Sheldon freaks out throughout the next few scenes. It goes on until Sheldon chokes the spitball back up as Howard quizzes him on engineering, making it at first seem as if he's stumped by the question.
  • Howard and Stuart's argument about Stuart's relationship with Howard's mother, Debbie. The crowning moment is when Stuart snaps at Bernadette, and we get this gem from Howard:
    Howard: Don't you talk to my mother... MY WIFE that way!
  • After Penny and Bernadette reconcile, they decide to go for drinks and want to ask Amy to come along. Cut to Amy eavesdropping on the whole thing from Penny's front door. She immediately runs back down the stairs to avoid being found out when they call her.
  • The sight of Amy and Bernadette at a Las Vegas bar drinking giant margaritas in "The Focus Attenuation".
  • To keep focused, the guys put duct tape on their arms as a form of aversion therapy; if one of them went off topic, a tape would be pulled out. Things go south very quickly.
  • In "The Prom Equivalency", Howard worries that his mother will be Stuart's date. When Stuart tells him he has a date, we get this:
    Howard: So now you're cheating on my mother?
    • Stuart's date then turns out to be Howard's second cousin Jeanie, with whom he lost his virginity.
  • At the fake prom, Penny talks about being relieved that they'll be none of the drama usually associated with proms. Answer Cut to Howard and Stuart fighting on the limo.
  • The guys' prom photos during The Stinger.
  • Leave it to Sheldon to Mood Whiplash a heartwarming moment into a funny one:
    Sheldon (to Amy): Just because I love you doesn't mean girls are allowed in my room!
  • While Leonard is under surgery in "The Septum Deviation", Sheldon freaks out when a tremor causes a blackout. He makes a run for the door, but it's locked and he slams his face on it. The next shot is of Leonard and Sheldon at home, both with bandaged noses.
    Sheldon: Don't try to stop me. (Slam!) Why didn't you stop me?!
  • Sheldon buying monogrammed funeral urns for him and Leonard. Leonard's reads "Here lie the ashes of Leonard Hofstadter. He thought he was right, but his roommate knew better." Sheldon's reads "I'm with stupid."
  • Howard reveals that he went to couples therapy without Bernadette. Bernadette naturally assumes it was with his mother. A few scenes later...
    Howard: We're saying all the things we love about each other.
    Raj: Oh, like you and I did at couples therapy!
  • The Fun With Flags best moments montage. Highlights include Sheldon as Betsy Ross, Sheldon and Amy in Old Timey Bathing Suits, and Barry Kripke playing "Flag or Not Flag".
  • In "The Clean Room Infiltration", Bernadette drives an annoyed-looking Sheldon to a mall while happily singing along to Christmas songs on the radio, until Sheldon gets fed up with the songs.
    Bernadette: Why'd you turn it off?
    Sheldon: Because in the last 10 minutes, Santa came to town, kissed Mommy, and ran Grandma over with a reindeer. I had a drunk uncle who did all those things, nobody sings songs about him.
    Bernadette: Maybe you'd like him more if you thought of Santa as a superhero and his power is bringing joy to children?
    Sheldon: My uncle was accused of that too! That turned out to be legal in Oklahoma.
  • The guys playing "Emily or Cinnamon?", trying to guess whether a quote from Raj refers to his girlfriend or his dog. Most of the answers are "Cinnamon".
    • At the end, Emily calls them out on it and says that she thinks it's romantic that Raj loves his dog as much as he loves her. They kiss and then...
    Emily: Why is there dog hair in your mouth?
  • Amy's Little House on the Prairie / time-traveling fan-fiction. Including the creepy-heartwarming scene in the episode's stinger.
  • To show his sense of humor on his application video for the Mars colony, Sheldon gives Leonard a can of peanut brittle. Leonard knows it's a prank, but plays along in an uninterested tone. He is then confused that the can actually has peanut brittle inside, and is then surprised by a Pie in the Face.
    • The video in general shows Sheldon being goofier, more congenial than usual, conveying his eagerness to go to Mars.
  • Sheldon & Leonard on whether or not to visit Skywalker Ranch:
    Sheldon: "Is that the attitude that helped you get Penny?"
    Leonard: "No, but I don't have three years to make that gate feel sorry for me."
  • Amy playing ping-pong. She serves like a pro, but can't return a serve to save her life.
  • Penny admitting that Leonard doesn't have to browbeat her into watching Game of Thrones, she likes it on its own merits: dragons and people doing it.
  • "The Maternal Combustion" has Sheldon and Leonard's mothers meet for the first time. It is as glorious as it sounds.
    Mary: A good Christian would have turned the other cheek. On the other hand, a good Texan would have shot her.
    • Words cannot express the sheer hilarity of the Snark-to-Snark Combat that Mrs. Cooper and Mrs. Hoffstadter engage in.
  • From the same episode, Howard cleaning the kitchen after he spilled garbage on the floor. He claims he mopped everywhere, then he steps forward and his shoe sticks to the floor. He confesses he may have missed a spot. And then his sock sticks to the floor.
  • Sheldon lets slip that Penny's engagement ring was inexpensive because the stone was a recycled diamond drill bit. Leonard later tells Penny that this is not the case. Penny tells him sweetly that she knows. Then she presses the ring into his arm while making an utterly adorable imitation of drilling noises.
  • As the gang heads to the prom in "The Prom Equivalency", Bernadette notices that Emily has a tattoo, which triggers this exchange:
    Emily: It's Sally from Nightmare Before Christmas.
    Bernadette: Ah, that movie's so cute.
    Howard: Do you like her because you both have red hair?
    Emily: A little, but more because she's covered with scars and can pull her own limbs off and sew them back on.
    Bernadette: (awkward pause) I like Cinderella.
    Emily: Did you know in the original book the sisters cut their toes off with knives in order to fit in the glass slipper?
    Bernadette: (another awkward pause; looking uncomfortable) I like "Bibbidi-bobbidi-boo".
  • Unable to fix a RC drone Howard is forced to call tech support. As the phone dials he mutters that he'll likly wind up speaking to a foreign guy with the same booklet he has. Then Raj's phone goes off.
    Raj: It's my father you jerks!

    Season Nine 
  • Sheldon's first episode of "Fun with Flags" after breaking up with Amy leads to this gem:
    Sheldon: (holding up a remote control for managing his camera) Thankfully all the things my girlfriend used to do can be taken care of with my right hand.
  • The guys trying to take a lugnut off of a tire using science accidentally set a van on fire.
  • While tapping on the lugnut to loosen it, the guys do an impromptu rendition of Queen's "We Will Rock You". And then Sheldon shocks everyone with a falsetto performance of the first verse.
  • The boys are learning fencing from Barry Kripke as a way to get more exercise. While practicing advancing and retreating, Kripke turns around to take a phone call and the guys start Flynning behind his back, resuming their positions after Kripke finishes his call.
    • Howard and Raj trading variations of My Name Is Inigo Montoya.
      Howard: My name is Darth Vader I am your father, prepare to die!
    • And this gem from Sheldon:
      Sheldon: Can I stab one of my friends?
      Kripke: We don't call it a stab. We call it a touch.
      Sheldon: Yes, but if I say I want to touch one of my friends I'll be called into human resources.
  • During a remodel of Howard's mother's house, Howard and Bernadette's father, Mike, in a crawlspace underneath the dining room, discover that Bernadette lied to Mike and said Howard didn't want kids... unaware that she and Raj are listening in from the dining room. How does Bernadette react?
    Bernadette: (starts rapidly stomping on the floor)' EARTHQUAKE!
    (Dust falls all over Howard and Mike)
    Howard: We're gonna die!
    Bernadette: (stops for a moment, then resumes) AFTERSHOCK!
  • Amy is happy because she seems to be moving along well in her relationship with someone new after the breakup. Until she happens to mention that her ex was a physicist named "Sheldon." As it turns out, her new guy (Dave) is a Sheldon fanboy who once drove 500 miles to hear him lecture. He can't shut up about him the rest of the night, much to Amy's chagrin.
    • Amy gives him a second chance after Sheldon rejects reuniting. Their date winds up with Sheldon showing up and telling Amy he loves her and wants to get back together. Dave is nothing if not helpful and supportive, once stepping out from behind the door and exclaiming "Kiss her you brilliant fool!" He then stands there for over a minute while abiding a Shamy makeout session, thanking Amy for a lovely evening and telling Sheldon he wants to discuss physics before Amy kicks the door shut on him. He still thinks of it as a great evening.
  • Sheldon, suffering from an earworm he can't recognize, wakes Penny and Leonard up playing it on his keyboard. Penny goes out and takes the keyboard away... And he starts up on the tuba.
  • When the website to buy Star Wars premiere tickets is frozen, Sheldon resorts to desperate measures: he prays.
    Sheldon: (getting down on his knees) Lord, this is Sheldon Cooper. You're good friends with my mom. I know I've spent my life denying that you exist...
    Howard: GOT THEM!
    Sheldon: (gets up, still looking up) AND I WILL CONTINUE TO DO SO!!!
    • Of course, the idea that the Big Guy actually answered his prayers never crossed his mind.
  • Wil Wheaton pulls an EPIC troll move by walking into the theater of the Star Wars premiere in full Star TREK regalia. He's lucky he made it out of the theater in one piece.
  • After having sex, Sheldon says that was more enjoyable than he thought it would be. Amy is then shown to be VERY pleased with the experience; crazy hair, big satisfied grin and everything.
    • Then Sheldon follows this up by saying he looks forward to doing it again NEXT YEAR on her birthday. Amy responds that the wait is worth it.
      • It gets better has it cuts to Leonard, Raj, and Howard having the same reactions to Sheldon and Amy having sex but to Star Wars: The Force Awakens instead.
  • Penny is so shocked by Sheldon talking about the "birthday gift" that she crushes the wine glass she's holding!
    • Then when Penny and Bernadette confess to Amy what Sheldon is planning:
  • Raj on a stripper pole which Penny and Bernadette enjoy. Howard and Leonard? Not so much.
  • Anything Adam West says in "The Celebration Experimentation". Notably, how his and the guys' conversation about the best Batman actors ends.
    Howard: Can we all just agree that we're worried about Affleck?
    Leonard and Raj: *Statements of agreement*.
    Adam West: What's an Affleck?
  • Zack, of all people, points out that Howard and Leonard's flawed reasoning when they think their gyroscope won't be used by the military even though it surpasses any steering system on the market.
    Zack: You sure you guys are smart?
  • Howard's paranoia that the government is after him leads to him being stopped by the cops for reckless driving, taking a field sobriety test while insisting to the officer that he's not on drugs and that the government is after him.
  • Beverly Hoffstadter and Mary Cooper once again engage in Snark-to-Snark Combat.
  • Mary Cooper bonding with Leonard's father over their mutual disdain of Beverly.
    Alfred: Yes, I’m an agnostic myself, but I prayed, many times, to turn my wife into a pillar of salt.
    Mary: Well, he came close. Turned her into a giant block of ice.
  • In-Universe, Penny is laughing her ass off with the realization that Mary and Alfred spent the night together.
  • Where was baby Halley conceived? Not just at Leonard and Penny's apartment — on Sheldon's bed. Upon hearing this tidbit, Amy lets out a Big "WHAT?!", while Penny covers her face and just shrieks.

    Season Ten 
  • "The Veracity Elasticity" is filled with a number of hilarious moments:
    • Raj and Howard as the house band for Sheldon's "Fun with Flags" web series. Sheldon likes the Rimshot from Howard's keyboard, but only when he asks for one.
    • Penny asking questions about the repairs to Amy's apartment and she goes into a "Fawlty Towers" Plot about how the dry wall got wet and became wet, er, damp wall and the wall store recommended they wait for an upcoming discount.
    Penny: "How long did you think you could keep it up?"
    Amy: "I was done by damp wall but you kept asking questions!"
    • Leonard learning that Penny has been secretly moving his collectibles out of the apartment altogether, and after several weeks he hasn't noticed.
    Leonard: She even moved my Waldo figurine!
    Sheldon: Oh, he's over there.
    Leonard: Oh, there he is.
    • Penny covered for Amy by claiming her apartment was still a mess. Sheldon and Leonard are confused, and so started speaking Klingon to each other to try and see through their deception. Amy and Penny retaliated by speaking the obscure language game Ubbi Dubbi so they could do the same. This scene is seen here.
  • Sheldon's attempts to seduce Amy in "The Brain Bowl Incubation". Yes, you read that right.
    Sheldon: Brandy?
    Amy: No, thanks.
    Sheldon: Good choice. It's disgusting.
  • The long series of Amusing Injuries Sheldon suffers in "The Geology Elevation".
    • First, Sheldon tries to throw a rock in frustration of Burt the geologist getting a MacArthur Genius Grant instead of him. Cut to him hobbling back home, having dropped the rock on one foot, and then hurting the other by kicking it. Leonard also got hurt... he got a nosebleed from laughing too hard.
    • Then, Sheldon went to thank Burt, who mentions that he could nominate someone for next year's MacArthur Fellowship grant... and is considering Howard. Sheldon walks offscreen, and then we hear a "thunk!", followed by him calling for Leonard. He had rammed his head on a water fountain, or rather, he slipped and hit his head trying to punch it.
    • Finally, Sheldon goes to apologize to Burt for being jealous of him. When the subject of Burt's former crush on Amy comes up, Burt mentions that now that he's rich, he thinks he can do better than her. Sheldon just looks at him. Cut to Sheldon having his hand bandaged up by Amy after karate-chopping Burt as Penny comments how she can't believe he hit someone.
  • Howard's remote control mini-Stephen Hawking. It doesn't just cross the line twice, it zigzags and does wheelies all over it.
    "Hey, good looking. How would you like to go for a spin?" (RC Hawking does a 360)
    "Ladies and gentlemen, start your wheelchairs."
    • Everyone Howard shows it to thinks it's offensive, except for Barry Kripke, which is what convinces Howard of how offensive it is.
    • The capper is that Hawking himself mentions that he would like a remote control toy of himself. The others agree never to tell Howard about this.
  • Halley Wolowitz is born and the group is standing at the nursery window, trying to figure out which one is her. Raj says that being the godparent he should be able to figure it out and suddenly a disturbingly loud and piercing cry is heard (very similar to how Howard's mother sounded), which clues everyone in on who the new Wolowitz is.
    • While on the way to the birth Raj complains that he wasn't there with Howard and Bernadette, replying to the statement that he spent 9 months helping Bernadette prepare for the baby while attributing Howard's role in things to 5 minutes making the baby. Then Sheldon comes out with this.
    "5 minutes? We must have been doing it wrong; took us hours."
    • The small but satisfied grin on Amy's face afterward.
  • Amy has a daydream of Sheldon working a train in overalls, doing manual labor and sweating up a storm. He then takes her bottled water and drenches himself in it. After spending most of the episode dreading the train vacation, she suddenly has to get there sooner.
  • Amy to Bernadette and Penny: "YOU HAD ONE JOB!"
  • From this season's blooper reel, there's one particularly hilarious moment from an attempt at the scene where Leonard tells Penny they're going to dance around in their underwear. The take is ruined because Kaley and Johnny are visibly distracted by an audience member audibly yelling "EW!" Even better is their response, jokingly pointing at the exit and yelling, "Out! Out! Out of our audience!"
  • In "The Hot Tub Contamination", Howard and Bernadette are appalled to learn that Stuart comes over to their house to use the hot tub when they are not around. Raj comes over and uses it as well.
    Stuart: (to Raj) One time they came early, but they thought I was a raccoon.
    Bernadette: (to Howard, as they spy on them) I told you raccoons don't say "Uh-oh!"
    • In the end, Howard catches Raj and Stuart red-handed as they decide to leave...
      Stuart: (to Raj) Give me a minute.
      Raj: Why?
      Stuart: You know how you're wearing a bathing suit?
      Raj: Yeah?
      Stuart: I kinda went the other way.
      Howard: (opening the window to yell at them) YOU JACKASSES JUST BOUGHT YOURSELVES A HOT TUB!!

     Season Eleven 
  • "The Proposal Proposal": Penny and Leonard both having forgotten their wedding anniversary.
  • After Sheldon tells him mother about his engagement, she thanks God and says that although He is all-powerful, that that must have taken quite a bit of effort.
  • "The Relaxation Integration": Sheldon decides to try wearing flip-flops in order to deal with his stress when he starts sleep-talking. Watch this to see the aftermath of the attempt.
    • The meeting of the Council of Sheldons in The Stinger, where all the facets of Sheldon’s personality (including Science Sheldon, Texas Sheldon, Germaphobe Sheldon, and Humorous Sheldon) vote on letting in Laid Back Sheldon. They vote no. Fanboy Sheldon asks if they can boot Humorous Sheldon too.
  • With both Howard and Bernadette on bedrest, Penny offered to help take care of Halley for a few days. They react with trepidation, as they never considered Penny to be very nurturing or good with kids. Penny barreled ahead and took care of Halley, and with Howard and Bernadette listening over the baby monitor Halley called Penny "Mama," her first words. Penny corrects Halley, but not without mocking them through the baby monitor.
  • In a flashback, a drunk Penny made a video apologizing to Leonard, filled with a number of great bits:
    • "I was going to use e-mail, but I'm a little drunk and spelling is a sober person's game."
    • "I feel I owe you a splanation... let me say that again, I owe you an ES-PLAN-ATION."
    • "I don't know how to spell 'Hofstadter.' I know there is a 'D' in there but every time I try it keeps moving."
    • Sheldon knocking on her door. Penny: "I'm making a video!" Sheldon: "Oh, I'll come back when you're alone."
    • Penny fell asleep on the keyboard, the video lasted two hours with her head in the way, at least until she slid off.
  • In "The Retraction Reaction," the guys all worry that their fields are a dead-end, and get raging drunk.
    • Leonard and Sheldon are sitting around being depressed when Raj and Howard come in. Raj launches into a rant about their whining, which leads to him depressing Howard and then himself.
    • In the end, they all come to the conclusion that science is only dead if they allow it to be... and then, the next morning, Leonard is called into Human Resources. Janine then proceeds to read aloud the email he drunkenly sent her. It starts by describing science as a zombie, and it all goes downhill from there. Even Janine is struggling not to crack up.
  • Howard and Raj's shoving match inside the bounce house in "The Celebration Reverberation".
  • In "The Geology Methodology", Raj has an imagine spot of Ruchi talking about germs in a sexy voice while her hair is blowing in the wind, and "Almost Paradise" in the background. This is funny on its own, but becomes hilarious when the gag is brought back at the end... When Sheldon has an identical imagine spot of Bert, complete with Bert's beard blowing in the wind.
  • In "The Reclusive Potential", the guys visit a physicist who lives as a paranoid hermit. Raj gushes over a tomato that he started eating for some reason, and the physicist tells him he fertilizes the tomatoes with his own manure.
    Howard: The look on your face.
    Leonard: It's a sort of grin. Guess what kind.
  • The very end of the finale. Sheldon and Amy have finally been married, and are joyfully going down the aisle... and then the music starts.
    Kripke: At waaaaaaaaast... my wove has come awong...

     Season Twelve 
  • The first leg of Sheldon and Amy's honeymoon is in Legoland. Sheldon brings Amy breakfast in bed... made of Legos.
  • Howard going as Sheldon for Halloween in "The Imitation Perturbation". Sheldon doesn't get it until Leonard points it out.
    • Sheldon getting even by going as Howard while Amy dresses as Bernadette.
  • Howard and Raj playing Fortnite together.
    Raj: Bam! Took him out! Now I'm doing a victory dance to celebrate. Where are you?
    Howard: About to shoot some dancing jackass.
  • In "The D&D Vortex", Sheldon finally meets William Shatner… and throws up on him.
  • The Stinger of that episode, with the girls at Wil Wheaton's Dungeons & Dragons game. Highlights include:
    • The Star Trek jar for whenever William Shatner does a Star Trek joke. He says it's Worth It.
    • Amy and Bernadette hitting on Joe Manganiello, who is clearly uncomfortable with it.
    • Wil sends a photo to the boys to rub it in their faces. Kareem Abdul-Jabbar's head is out of frame.
  • "The Laureate Accumulation" is about the university inviting Nobel laureates to promote Sheldon's bid. One problem: Sheldon has managed to insult each and every one of them.
    • To make it up to them, Sheldon and Amy sends them cookies. These are their reactions:
      George Smoot: Sheldon Cooper? Hmm... [throws cookies in trash]
      Kip Thorne: Sheldon Cooper? Pass! [hands cookies back]
      Frances Arnold: Sheldon Cooper? Aw. Ugh, oatmeal raisin! [throws them in trash]
      • And one more, Saul Perlmutter, sent a photo of the cookies.
      Sheldon: Aw, he arranged them to spell out "thank you".
      Amy: Sheldon, that word isn't "Thank".
      • The Spanish dub changes it up, but it's equally funny:
      Sheldon: Aw, he arranged them to make a thumbs up.
      Amy: Sheldon, that finger isn't a thumb.
    • The Cold Open has Drs. Campbell and Pemberton (who accidentally confirmed Super Asymmetry and are being nominated for the Nobel Prize along with Sheldon and Amy) appearing on Ellen DeGeneres' talk show, not for the discovery, but for their silly internet videos. Sheldon seems to have Ellen confused with a serious journalist, as he keeps hoping for her to expose them as frauds.
      Leonard: That is Ellen's brand, gotcha journalism.
    • Sheldon's reaction to Amy's big blow up at Drs. Pemberton and Campbell.
    Sheldon: Is that what I would've sounded like?
    Leonard: Yeah.
    Sheldon: Yikes!
  • While waiting for the Nobel Prize committee to call Sheldon and Amy, they get a prank call from Kripke, saying that they just won the Nobel Prize for being Suckers.
    • Sheldon falls asleep before the call comes, and Leonard is eager to slap him awake. But before he can, a phone call wakes Sheldon up. After the call comes that they won, Sheldon asks if he's dreaming... and that's when Leonard smacks him. Sheldon's reaction is initially shock, but quickly turns into glee "We won a Nobel!"
  • Sheldon and Amy step out of their building and are confronted by a swarm of reporters. Sheldon does the obvious thing: running back inside.
    Reporter: Is Dr. Cooper coming back?
    Amy: No. Next question.
    • Howard finds a reporter at Sheldon's office door. He peeks inside and finds Sheldon hiding behind his desk, shaking his head no.
  • The biggest reveal of the finale: the elevator is finally fixed!
    • Sheldon has a Freak Out and runs downstairs, Penny takes the elevator and beats him to the first floor.
  • As the gang is headed from Leonard and Penny's apartment to the airport, they have trouble getting all their luggage down. Cue a hilarious couple minutes of all of them trying to squeeze themselves into the elevator with their luggage. They solve it by putting it all in the elevator and going downstairs to pick it up.
    • Then, of course, Reality Ensues and they have to dig it all out of the elevator. Apparently, just taking multiple trips never occurred to them.
    • While trying to figure it all out Bernadette gets stuck behind the luggage. All we see is the top of her head and her screaming "Help me!"
  • While Penny is having morning sickness, she and Leonard discuss how Sheldon is effectively their first child, meaning they'll be better prepared once their own child is born.
  • Sheldon winds up announcing Penny's pregnancy in his speech. She comments that she hadn't told her parents yet (but was too busy smiling and crying happy tears to really care at that point). This prompts Sheldon to apologize to her and then he asks the audience to not tell anybody else, even though this is at the Nobel Prize Ceremony that's being televised for the whole world to see.
  • Raj's date to the Nobel Prize ceremony is Sarah Michelle Gellar, whom he meets in the plane.
    • Just the fact that in the show's reality, "Is that Buffy the Vampire Slayer?" is officially in a Nobel acceptance speech.

  • It's not technically on the show, but there's Sheldon hacking into Super Bowl XLIV (The one in 2010 for non-NFL fans).
    Sheldon: Go, whatever team you support, and may the other team play less effectively!
    • Followed by the announcer:
      Announcer: Leave it to Sheldon. He hacked his way into the Super Bowl.
  • At Comic-Con 2011, an audience member asked who had the best "Howard's Mom" impersonation. Simon Helberg (Howard) barely got out a screechy "Howard" before admitting that's all he had. Melissa Rauch (Bernadette) took a moment to think, then did a flawless Howard's Mom voice with "What's this 'Comic-Con' you're at? Is that some sort of sex convention I saw on ''20/20''?"


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