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Bizarre Human Biology

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No one man should have all those bones.

Maybe the character was born a mutant, or belong to a Human Subspecies, or have gone far enough up the Evolutionary Levels as part of the goal of evolution, or underwent extensive Bio-Augmentation of the essentially permanent kind... Or perhaps they were even created as an Artificial Human from the get-go. The bottom line is, this human character's biology, while not technically alien, cannot be considered "normal human" by any stretch of the term, be it due to having extra organs (duplicate or not), wildly different biochemistry, abnormal nutritional requirements, or even possessing completely new cellular organelles.

Note that not all cases of Human Subspecies, Transhumans, Mutants, Bio-Augmentation, etc. lead to Bizarre Human Biology. They are only possible ways for attaining this trope.

Compare and contrast Bizarre Alien Biology, which may overlap with this trope in cases of Half Human Hybrids or Panspermia.

Compare and contrast to Our Humans Are Different, which is about all humans being significantly different than in real life.


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    Anime and Manga 
  • The titular Canaan has synesthesia, which translates as Aura Vision for her. One example has her seeing the bits of code needed to hack a door that a professional hacker couldn't get. Too bad that hacker was Alphard.
  • Souther in Fist of the North Star has situs invertus totalis with dextrocardia, and he's found a way to utilize this quirk as his Emperor's Armour, meaning that Kenshiro's first attempt to defeat him fails utterly. Because all of Souther's organs are inverted in his body, so are the pressure points that Kenshiro's Hokuto Shinken style relies on. When Kenshiro learns Souther's secret during their second battle, the Holy Emperor's fate is sealed.
  • Hinted at in Free!, of all shows, with Rin Matsuoka. As a child he had Cute Little Fangs, but the prequel movie shows him with his signature shark teeth by puberty, implying that he either grew a third set of teeth (impossible for mammals, let alone humans) or they somehow became sharp. Oh, and he inherited the condition from his father, but his sister has normal teeth, implying it to be some sort of chromosomal mutation. Then again, this is a series where hair can be raspberry-red, blue, pink, or dark green...
  • In Mission: Yozakura Family, Nanao's Yozakura talent manifests in his body's ability to naturally mutate into a stronger and more resilient form that adapts to most kinds of danger and stimuli. In addition to having a powerful immune system that can destroy most bioweapons simply by consuming it, he is able to synthesize drugs within his own body and vomit them up as egg-shaped pills later. It's also implied that he can force parts of his body to grow at will given the color spreads, and his fingernails can distend into claws.
  • My Hero Academia: Quirks have vastly changed the nature of what it means to be human. Not only do most people have some sort of awesome superpower that is tied to some sort of physical mutation (Bakugo sweats nitroglycerin that he can detonate at will, Jiro has organic earphone jacks that she can plug into objects to enhance her hearing or amplify her heartbeat as an attack, Iida has engines in his legs), there are also a lot of physical mutations that seem entirely unconnected to the power. Tokoyami has a bird's head (his power is a Living Shadow), and Kirishima has razor-sharp teeth (his power is Super-Toughness). Even people without awesome powers are born with some quirk (the protagonist's mother, for example, can make small objects levitate). In fact, being born a Muggle is considered a rarity.
  • In Tokyo Ghoul, both humans and ghouls possess structures called Rc cells, which are described as "liquid muscles" and can become as solid as teeth. However, ghouls naturally have much higher levels of these cells than humans. By concentrating these cells in a sac-like organ in their back, they can manifest a Lovecraftian Superpower called a kagune, which is used for hunting and combat. The form it takes depends on the ghoul's Rc type.
  • Toriko is full of this, thanks to Gourmet Cells sometimes causing mutations. The Gourmet Corp is full characters with abnormal bodies; pictured above is Bogie Woods, whose skeleton has 4K bones, which allows him to insert himself into people and control them from within.

    Comic Books 
  • The DCU:
    • Batgirl (2000): Cassandra's blood chemistry is so unusual that the government scientist ordered to analyze it thought he was being pranked. This despite the fact that, according to his analysis, she's entirely human from a genetic standpoint. The series never explains this, nor does it explain her seemingly superhuman prowess beyond a vague "gift" inherited from her mother, despite the aforementioned lack of any superhuman genetics.
    • Batman: Killer Croc is allegedly a human who was born with a very rare skin disease, but many artists have started to make him less and less humanlike and more reptilian in appearance, sometimes having a crocodile snout and tail. One writer has Hand Waved this as being a mutation in his disease that grants him traits of more primitive animals.
    • Plastic Man is inorganic after his Freak Lab Accident; this actually makes him immune to psychic phenomena, since his brain itself is apparently plastic.
  • Marvel Universe:
    • The Avengers villain Whirlwind has higher viscosity in his bodily fluids, compared to motor oils, to survive the rigors of Super-Speed spinning on his physiology.
    • Doctor Strange, during the Jason Aaron run, still looks human on the outside, but years of exposure to magic has taken its toll on him. He can no longer eat food that humans normally eat for one thing. Most of what he eats and drinks looks like it's from another dimension (and it probably is). Even worse, it tastes as bad as it looks — Stephen at one point complains that his meal tastes like leprosy. Still worse, Wong notes that even though that kind of food is the only kind Strange's body can accept, eating it will still eventually kill him. This aspect of the character has been completely ignored since Aaron left the title.
    • Iron Man: Post-Extremis, it's revealed that Tony had managed to change how his insides were organized.
    • In Mystique, the eponymous shapeshifter is shown to be able to rearrange her internal organs, grow a face on the back of her head, or even grow additional arms.
    • Ultimate Fantastic Four: Mr. Fantastic's body is an infinitely extensible fluid-filled sack containing, in place of an alimentary canal and other organs, just a squishable bolus of microbes that perform all metabolic functions. It's definitely Artistic License – Biology, though fans chalk it up to Rule of Cool and leave it at that.
    • X-Men: Hank McCoy, the Beast, once explained that his circulatory system is different from the average person's. This was stated by his younger self before his mutation advanced, so presumably this was always true along with his enlarged hands and feet.

    Fan Works 
  • Neon Genesis Evangelion: While Rei Ayanami is canonically known to be at least partially human, the specifics aren't made clear. To compensate, Fanfics tend to depict her with either this trope, Bizarre Alien Biology, or both, each in various ways. To list them all would be a herculean task, given the size of the fandom; one notably common issue, however, is whether or not she has an S2 Engine/Organ, and its exact role in her physiology.
Specific Works

  • Addams Family Values: In addition to the weird biology the Addamses have in the series, their second son Pubert is born with a mustache, and when he gets sick, his hair turns blond.
  • Crimes of the Future (2022):
    • The protagonist, Saul Tenser, is a performance artist whose body spontaneously grows superfluous internal organs, and whose "performances" revolve around having those organs surgically removed by his partner Caprice. Notably, the process of growing these organs is explicitly shown to be anything but pleasant for Saul, who relies on technology to help his body eat and sleep with the discomfort.
    • Humanity itself has also physically evolved beyond the point of feeling pain or being struck down by disease, and people using surgery to turn themselves into this trope has become a fashion statement.
  • Everything Everywhere All at Once: One of the alternate universes Evelyn encounters is one where humans have flimsy hot dogs for fingers and ejaculate ketchup and mustard into each other’s mouths from their hot dog fingers. The technicians guiding Evelyn say she basically went "off the map" when traveling universes, as such a significant change in human evolution would have a Point of Divergence millions of years ago. (We see a 2001-inspired flashback where a primitive hominid tribe with hot dog fingers defeats a normal one.)
  • In The Man with the Golden Gun, the titular man with the golden gun is a Professional Killer named Scaramanga, who aside from using a golden gun and requesting a million dollars for every hit, is distinctively known for having a supernumerary nipple (see Real Life section). James Bond uses a prosthetic when posing as him to a man who has hired Scaramanga, but never met him.
  • Poor Things: Due to his father's tampering, Dr. Baxter doesn't have a functional gastrointestinal tract like other humans. He has to eat while hooked up to some complicated machinery full of bubbling liquid, and excretes via bubbles that he burps out.

  • The Bleeding Man: No one can figure out how the titular character keeps bleeding, or how to stop it.
  • Craft Sequence: The Deathless Kings are undead human skeletons that can still eat, drink, and have sex.
  • Death Star: Dr. Divini operates on a human male suffering from appendicitis and finds out that the guy also has situs inversus — his appendix is located in the lower left part of his belly instead of the right. Dr. Divini also speculates that Vader had to be encased in a suit with an artificial respirator and artificial limbs because Vader had rare genetic defects that would cause him to reject any transplanted organs — including those cloned from his own genetic material.
  • Diary of a Wimpy Kid: In "Hard Luck", Fregley can blow a bubble out his belly button.
  • Distress: One Crazy Survivalist has loaded himself up with so much Bio-Augmentation to survive any possible apocalyptic scenario that he doesn't even have DNA in his cells anymore. He can also digest tire rubber in a pinch.
  • Eighth Doctor Adventures: The Blue Angel features an Alternate Reality Episode in which the Doctor is theoretically human. He has two hearts, no navel, and an unusual aversion to the cold. It's probably related to the fact that he's half-mermaid.
  • "The Image in the Mirror", a mystery story by Dorothy L. Sayers, has as a key plot point that one of the characters has situs inversus, a rare congenital condition where the positions of one's organs are mirrored compared to how they usually are (i.e., heart on the right side, liver on the left, etc.).
  • Janitors of the Post-Apocalypse: A plague swept humanity, killing most people and rendering the remainder into Technically Living Zombies called 'feral humans'. Feral humans have syrupy black blood, feel no pain, have much lower body temperatures than pre-plague humans, and are nearly unkilleable. They're ravenous and most interested in warm-blooded prey but will eat anything, including each other if they can't find plants. After fifty years, the Krakau arrived and started uplifting individual feral humans. These "cured" humans, recruited into the Krakau military, are intelligent but less so than pre-plague humans, retain mostly feral physiology and durability, and are fitted with ports for feeding tubes because one, the Krakau think that human food is gross and two, there's some risk of reverting to a feral mindset associated with eating by mouth.
  • Known Space: Humans, like all species descended from the ancient Pak, retain the ancestral ability to transform into beings known as protectors when they eat a specific root and the symbiotic virus within it. Among other things, a mature human (or Pak, or whatever else) protector has a beak formed from their fused gums and lips, skin with the toughness and consistency of leather armor, no sexual organs, a five-lobed brain, and a second heart in their groin.
  • "Mimsy Were the Borogoves": The anatomical doll from the future, presumably of a future human, has different organs compared to a present-day human. This includes a shorter digestive tract, no large intestine or appendix, a difference in the aorta, and a network that goes throughout the body, is attached to the lungs, but is not a circulatory or nervous system.
  • Oceanic: Humans of the planet Covenant, who are descended from a group of transhumans who have since rejected The Singularity, are not described in too much detail, but the main feature that is different from actual humanity is that the male's penis is apparently detachable, and passes to the female during sex, at which point it is grafted onto the female and the male grows a vagina.note  Unfortunately for the readers, they find this out in the middle of a sex scene.
  • Human soldiers from Old Man's War have their brains downloaded into genetically engineered bodies that have green photosyntesizing skin, cat eyes and nano-bots instead of blood.
  • Inverted in The Things. The humans in the story are perfectly normal... but as a result, they're utterly baffling to the alien. We can't shapeshift like all other life in the universe, we can't truly communicate beyond exchanging grunts, and our minds aren't disseminated throughout all our body cells but left coiled up inside cystic nerve fibers locked within bony cavities. To a creature that doesn't understand the concept of individuality, we're miserable, lonely, barely sapient tumors.
  • In Alan Dean Foster's Tipping Point Trilogy, body modification has become basically as easy as getting a haircut. Power Perversion Potential is rampant.

    Live-Action TV 
  • The Addams Family:
    • The entire family is immune to poisoning, electricity (besides having a tickling sensation), and fire.
    • Uncle Fester produces electricity and requires mercury to be able to do so.
    • Morticia can "smoke" by producing smoke from her body, and her sister Ophelia can grow plants on her head.
  • Doctor Who: The Doctor's companions, as a result of exposure to the Time Vortex, are altered on a genetic level. Results include altered white blood cells and Ripple-Effect-Proof Memory.
  • The Sebeceans in Farscape are Transplanted Humans descended from Super Soldiers who were genetically engineered by aliens long ago. They have improved physical strength and eyesight (humans are apparently practically blind by the standards of other races) but fewer redundant organsnote  and an extreme (seriously) weakness to high temperatures. Also, their women can delay pregnancy once an egg is fertilized (until such time as it is convenient to grow the baby), and pregnancy is accelerated once it is actually begun.
  • Situs inversus turns up in Orphan Black, used as the explanation of how Helena survived being shot in the chest. Genetic chimerism later makes an appearance in Kendall Malone, whose two separate DNA profiles were duplicated to produce two lines of clones.
  • Prey: While most differences between humans and Dominants are mental in nature, a discovery of mummified remains of a Dominant 9-year-old girl from half a century ago reveals that Dominant females are born with four uteri and are able to give birth around that age. In fact, they can give birth to all four offspring much easier than human women. This is, likely, an evolutionary advantage to speed up the rapid growth of the Dominant race. By 1998, it's estimated that there are about 200,000 Dominants in the world, and that number is quickly increasing. On a smaller note, their crania are slightly smaller than human with a significantly higher number of synaptic connections (i.e., their brains are smaller but much more efficient). They are also much more comfortable in hot climates than humans, suggesting that Sloan's guess about Global Warming being the trigger may have a grain of truth in it.
  • The Zephryians in Son of Zorn are animated humans. They can mate with un-animated humans and have children. Male Zephryian humans have two penises, two scrotums and a man-womb.
  • In Supernatural, the Special Children develop psychic powers, the ability to kill with a touch, and super-strength after being fed demon blood as infants. Sam at one point is stated to have a body temperature far higher than a normal human can survive.


  • Journey into Space: In The Red Planet and The World in Peril, the Martians altered the biology of many humans so that they could survive in the Martian atmosphere.

    Tabletop Games 
  • Stormwild Islands: Due to excess magic leaking through from the Fontlands, many humans are born with unusual features. These range from unusual hair, skin, and eye colors all the way up to wings and tails.
  • Warhammer 40,000:
    • Adeptus Astartes. To wit, they have 19 implanted organs aside from the normal human organs: A secondary heart. An organ that increases bone structure and makes their ribcage bulletproof.note  An organ that makes their muscles grow vastly larger and more powerful. An organ that increases their blood's clotting ability. An organ that allows them to only need 4 hours of sleep and can go for two weeks without any sleep at all. A pre-stomach that can neutralize otherwise poisonous or indigestible foods. An organ that allows them to "learn from eating".note  A third lung that allows them to breathe in toxic atmospheres and underwater. An implant giving them far-superior vision to humans. An implant that makes them immune to motion sickness and the ability to consciously filter sounds. An implant that allows them to enter a healing coma/suspended animation.note  An implant that controls the amount of melanin in their skin.note  An organ that quickly filters the Marine's blood, rendering them immune to most poisons.note  An organ that enhances a Space Marine's sense of taste to such a high degree that he can identify many common chemicals by taste alone, or even track down his target by taste. An implant that allows a Space Marine to sweat a substance that coats the skin and offers resistance to extreme heat and cold and can even provide some protection for the marine in a vacuum. An organ that allows the marine to spit a blinding contact poison, which is also corrosive and can even burn away strong metals given sufficient time. Implants that are the base for the other organs. And finally, an implant that allows a Space Marine to interface directly with his Powered Armor. Many Black Library writers and 40K characters use the term "posthuman" to refer to Astartes for a reason.
    • The Primarchs. All of the Astartes above are derived from the Primarchs' genetic material, and they were created from the Emperor's genetic material. While the details of their biology remain unknown, the Primarchs' and the Emperor's superhuman abilities are signs that beneath the surface, their bodies were very different from the bodies of normal humans. A combination of this, his own psyker abilities, and the Golden Throne (which is falling into disrepair) are probably what's keeping the Emperor barely alive even though most of his body has rotted away after Horus tore him apart.
    • The Primaris Marines engineered by Cawl have three additional organs. They have metal coils that reinforce their sinews to enhance strength, a brain implant that improves the performance of the other implants (which is actually half of the original God-Maker organ the Emperor used in the creation of the Primarchs — the plans for the other half were destroyed), and a heart implant that pumps the Primaris Marines full of stimulants when they are on the brink of death to jumpstart repair of bone, muscle, and tissue.

    Video Games 
  • The people of Yharnam from Bloodborne end up turning into werewolves and monsters due to experimenting with alien blood they found deep in the catacombs under Yharnam. The fact that the people of Yharnam were so accepting with the drinking and injection of blood in the first place implies that the humans of this world are vampiric in nature.
  • Don't Starve characters have bones in their hair, visible if they get struck by lightning.
  • This is a plot point in the final mission of Hitman (2016), titled "Situs Inversus". One of 47's final targets, ICA Training Director Erich Soders, was born with the titular condition, causing all of his internal organs to be mirrored. He also requires a heart transplant, and the rarity of his condition has made getting a right-sided replacement heart very difficult. This has made him to desperate enough to resort illegal and immoral means to obtain a replacement heart in time, ultimately causing him to betray the ICA by selling confidential Agency client and operative information to Providence. His condition also means that if you find and destroy the donor heart, the hospital will not be able to find another heart in time, thus dooming the target to a slow but inevitable death.
  • Metal Gear:
  • In Parasite Eve, the protagonist Aya possesses a more benign/passive form of the "evolved" strain of mitochondria serving as the franchise' Big Bad, which are not only a self-aware Hive Mind that can act like The Virus, but they also possess actual superpowers, including Spontaneous Human Combustion and Body Horror transformations!
  • Overwatch has plenty of humans who are enhanced with cybernetics to some capacity, but by far the strangest example is Mauga, who — as a result of a life-saving emergency surgery — has two hearts, one organic and one cybernetic. This is presumably what allowed him to become the incredibly strong mountain of a man he is without his body completely giving up on him.
  • Sakura Wars: So Long, My Love reveals late in the game that Gemini Sunrise was born with two hearts, one of which is tiny and non-functioning. When she was conceived, she was actually originally meant to be born as a set of twins, but she was the only one to be born, having absorbed her twin sister in utero. This secondary heart would go on to serve as the core of Gemini's Split Personality/Evil Twin Geminine.
  • Team Fortress 2: Even disregarding the questionable medical ethics and arbitrary heart and other organ transplants the Medic performs, the Demoman's body is so alcohol-dependent that it can barely handle solid food and will ferment his bone marrow if denied outside sources.
  • In the Enemy Within expansion for XCOM: Enemy Unknown, you can use "meld" to extensively modify your soldiers' bodies. You can give them chameleon skin, two hearts, regenerative bone marrow, leg muscles to allow them to jump like fleas, aim-correcting eyeballs; the list goes on and on...

    Visual Novels 
  • Aoba from DRAMAtical Murder has hair with nerve endings in it. In his backstory, it's revealed that he was born attached to his twin brother from it.
  • In the latter half of Songs and Flowers, Jazz is revealed to be a genetic chimera and possesses two different blood types. This proves to be a difficult hurtle during her mother's murder investigation.

  • Alice Grove: Referenced in a conversation between Gavia (a nanomachine-enhanced cyborg) and Sedna (a Super-Soldier with extensive modifications, including quantum entanglement with a black hole to let her violate the laws of thermodynamics):
    Gavia: [changes her skin color with a thought] I lost my nanotech. I'm not baseline.
    Sedna: Hey, preachin' to the choir, here. I can photosynthesize if I have to.
  • In Ask White Pearl and Steven (almost!) anything, Steven is the Half-Human Hybrid son of Greg Universe and White Diamond. White Diamond was taller than the Crystal Gem's temple and her gem large enough to match. Because of this, Steven lacks a human brain, the majority of his mother's gem occupying the majority of his skull cavity and the pointed end of her gem visible as a small horn on his head.
  • Ennui GO!: The SJW with his many buttholes, Noah's freakish elephant penis, and Jerry all come to mind.
  • In Hell(p), some people get random non-human features after they die, which can be as small as a weird eye color or as big as an extra set of limbs, and anything in between. Also, everyone has a Wound That Will Not Heal which doesn't kill them, even though it's possible to die of physical trauma in this version of Hell.
  • Italy's Idiot Hair in Hetalia: Axis Powers is shown in the comic to be an "erogenous zone". It's unclear if the note was referring to his scalp reacting to the hair being pulled, or if he has actual feeling in the hair, but the fandom tends to run with the latter, and usually applies the same principle to the other curl-bearing nations. At least one fic goes to the logical extreme of the hairs being sensitive and has one bleed when severed. Also, Norway's curl actually floats around, detached from his head.
  • In Quantum Vibe, when Seamus is originally introduced he has some physiological abnormalities due to a botched rejuvenation: gigantism combined with a metabolic disorder that made him morbidly obese, nerves in his hair, and the ability to fart at will. He had most of the problems fixed during the Luna arc, though he's still pretty tall.

    Web Original 
  • The Ningen: Ningen (which literally translates to "human" from Japanese) are Antarctic cryptids that are essentially a supernatural sub-species of human with different morphologies based upon their stage.
    • Stage 1 is terrestrial and has a long neck, a short rib cage, and massive arms and hands it uses for locomotion and hunting. Its legs are missing from the knees down, while the thighs connect to the elbow.
    • Stage 2 once again has long arms, but is now aquatic and adapted its spine and ribs into a long and hydrodynamic body.
    • Stage 3 discards all its limbs, including its head, and is now able to fly in the air. It also appears to be able to extend some form of tentacle from the top of its spine to strangle human prey. They can also merge with boats and absorb their crew.
    • Human Factories are when a Stage 3 merges with a ship to asexually reproduce red humanoids, which in turn can asexually produce more of the same humanoids.
  • SCP Foundation: SCP-811 ("Swamp Woman"). A human mutated into a Tragic Monster, she has an incomplete digestive tract, absorbs nutrients through her skin, and has decaying liquid flowing through her circulation instead of blood. Furthermore, her only method of voiding waste is to vomit. She can also produce a mucus-like substance on her hands which causes unprotected skin to rapidly undergo necrosis on contact, has an undescribed symbiotic species of bacteria in her circulatory system that she uses to metabolize nutrients and can only remove digested food from her body by converting it into tar and throwing it up as projectiles, a method she also uses while hunting.
  • Stupid Kids: In És mind nekem tapsol (And they all clap for me), when Boti gets shot in the head, he wakes back up stating that he cannot be killed by a headshot because he has a toaster instead of a brain.
  • Zsdav Adventures: In A torony (The tower), Zsdav and Freezzy try to sneak behind the Evil Wizard. But he tells them he has eyes on his behind, this freaks them out and they retreat.

    Western Animation 
  • Futurama:
    • The sewer mutants are a group of humans who live in the sewer but developed strange genetic quirks (different ones for every individual) due to radioactive waste mixed with the human feces. Among the biological oddities seen in sewer mutants are a single eye, a third arm, green skin, a singing boil, laying eggs, tentacles, gills, purple hair, and a pig nose.
    • Zoidberg views human biology in general to be this way. It's the main reason why he's so incompetent as a doctor. However, Zoidberg is actually an excellent doctor when it comes to other aliens, and he knows a lot about Bizarre Alien Biology.
  • The Loud House: Flip has two butts, calluses all over his skin, his heart is in his abdomen, he feels a brain freeze in his knee instead of his actual brain, he can burp out his ear, his burps can wither plants, he has one single super-strong leg, he can grow more hair when angry, he's immune to hypothermia, and he grew a second set of wisdom teeth.

Alternative Title(s): Bizarre Human Biologies