Dennis & Dee's Family
Frank's gold-digging ex-wife and Dennis and Dee's mother. She was a cold, cruel, selfish woman with little affection for her family. Frank referred to her as his "whore wife".
- Abusive Parent: To Dee more than Dennis. In her will she leaves Dee with nothing and explicitly calls her "an embarrassment and a mistake".
- And There Was Much Rejoicing: After her death, attitudes range from apathy to outright celebration. Frank pops champagne while Dee and Dennis are largely concerned with what she's left them.
- But for Me, It Was Tuesday: She reveals that Frank isn't Dennis and Dee's biological father as if she's talking about the weather.
- Dropped a Bridge on Him: Dies off-screen in "Dennis and Dee's Mom is Dead," from a botched neck lift. Dee and Dennis don't care, and Frank is downright celebratory.
- Gold Digger: Married Frank for his money.
- Greater-Scope Villain: See Minor Major Character below. If not for her, Dennis, Dee and even Frank may not have been as bad as they are today.
- Hidden Depths: She wills all of Frank's money to Bruce Mathis, crediting him as "a handsome man with a beautiful soul". A surprisingly humane mindset coming from a woman like Barbara. Then again, it could just be another jab at Frank.
- It's All About Me: She is very self-centered and smug.
- Jerkass: Relentlessly cruel and abusive to everyone she meets, but especially towards Dee.
- Karmic Death: It's oddly fitting that Barbara would die as a result of an unnecessary surgery she got to appease her own vanity.
- Lack of Empathy: She stole medication from dying children and chastised Dee for telling one of them they won't die after they asked her if they would because "if they die, you'll look like a fool".
- Minor Major Character: Only gets a few appearances before being permanently killed off, but is a major reason why Dennis and Dee became the awful people they are today, as well as why Frank became disillusioned with his wealth. Essentially, she's responsible for three-fifths of the Gang even existing.
- Mrs. Robinson: Subverted. She banged Mac, but only to upset Frank and actually finds him quite unattractive.
- Narcissist: See It's All About Me.
- Parental Favoritism: Towards Dennis.
- Really Gets Around: Cheated on Frank frequently, and he in turn calls her his "whore ex-wife".
- Rich Bitch: Well, she did marry a rich guy for his money.
- Smug Snake: See It's All About Me, again.
- The Sociopath: The worst sociopath in the entire series, which is saying a lot.
- Your Cheating Heart: She cheated on Frank with Bruce Mathis. Considering what we know about Barbara, it's likely she went through most of Philadelphia while married to Frank.
Dennis and Dee's biological father. The antithesis of Frank Reynolds, Bruce devotes his time and money to charities and philanthropic efforts, including adopting several suffering children in Africa.
- Good Is Not Soft: When Frank and Dee try to trick him into giving them the fortune Barbara left for him, he tries to teach them a lesson by pushing them to their limits.
- Horrible Judge of Character: It takes him less than one episode to see the Gang for what they are...but he's almost shockingly blind to the fact that Barbara is probably worse than all of them put together. He also assigns all the blame to Frank for the way Dennis and Dee turned out.
- Nice Guy: He does volunteer work and is very nice and courteous to Dee and Dennis before realizing they're bad people.
- Only Sane Man: He starts out as a very reasonable person, but his desire to get the better of the Gang makes him quickly lose his rational demeanor.
- Opposites Attract: Evidently. The show doesn't go too deep into their past relationship, but somehow the benevolent, charitable Bruce Mathis was once drawn to the arrogant, narcissistic Barbara Reynolds.
Gail the Snail
Dennis and Dee's cousin.
- Abhorrent Admirer: To just about everyone. Both platonically and sexually.
- Beauty Inversion: The very attractive Mary Lynn Rajskub gunged up as a slobbery, disgusting creep.
- Gonk: She's as unpleasant on the outside as she is on the inside.
- Have I Mentioned I Am Sexually Active Today?: She brags about losing her virginity twice despite being 33 years old, once to her own mother.Gail: Guess what mom, I'm sexually active!Donna: You're 33, you're supposed to be sexually active!
- In-Series Nickname: She has two of them - primarily "Gail the Snail", largely due to her mucus and the fact that the only surefire way to get rid of her is to salt her. She's also known as "Garbage Pail Cousin", since she's generally disgusting.
- Manchild: Gender-flipped and downplayed, but there. She's in her thirties but acts like a desperate teenager who just wants to fit in.
Dee and Dennis' grandfather on their mother's side.
- Identical Grandson: A photo of a young Pop-Pop shows he was the spitting image of Dennis.
- Nazi Grandpa: His Nazi-war-veteran status and prejudices cause Dee and Dennis to be unsure about whether or not to pull the plug on him. This is because on one hand, they'd be killing a family member, but on the other hand, he's a nazi.
- Those Wacky Nazis: Fought in WWII on the side of the Germans and still believes in Aryan superiority.
Charlie's mom, a sweet and timid woman who is attracted to cruel men. She had a one-night stand with Frank Reynolds 30 years ago, possibly making him Charlie's biological father.
- Abusive Parents: While she's a genuinely nice lady, her obscene over-protectiveness of her son, mixed with her own warped views of the world impacting his development, led Charlie to become the borderline-feral man that he is today. It's implied that Charlie also blames her for him being molested by Uncle Jack.
- All Girls Want Bad Boys: When Frank was with her, he would treat her like crap because "The woman prefers to be treated like crap. [He's] never seen anything like it." and says that sometimes it's too much even for him. Charlie later tries to break them up by setting her up with Mac's dad, informing her that he was in prison. And it works.
- Beware the Nice Ones: Has attempted to kill Mrs Mac in her sleep at least once. Dennis also describes her interactions with Mrs Mac overall as being a form of psychological abuse after observing their relationship for several hours.
- Cloud Cuckoolander: Not quite as obvious as Charlie, but almost every episode featuring her shows her to be as weird as he is in her ridiculous beliefs and superstitions.
- Extreme Doormat: To call her weak-willed and timid would be quite the understatement. She's evidently an extreme masochist who enjoys being mistreated.
- Female Misogynist: She doesn't trust other women, and panics when she realizes that the plane she's on is being piloted by women in "The Gang Beats Bogs: Ladies Reboot".
- Hooker with a Heart of Gold: Played With. In the Christmas Episode, she's revealed to have been a prostitute and is one of the nicer members of the cast. But she also has severe mental issues and is a xenophobe.
- Nervous Wreck: She's very timid and shy. "I don't want a dog to eat my face off, Charlie!"
- Nice Girl: While her ridiculous coddling of Charlie was abusive in its own way, Bonnie is the only parent besides Frank that is ever nice to anyone, and acts sweet and welcoming to the Gang whenever they visit her. She's still a pretty horrible racist, however.
- Odd Friendship: With Mrs. Mac, after some initial difficulties that involved Mrs. Mac strangling her a tad.
- Racist Grandma: She bonds with Mrs. Mac over their mutual racism.
- Really Gets Around: Aside from the dozens of men she had sex with while being a prostitute, she's slept with both Frank and Luther.
- Shrinking Violet: Older, but has severe nervous issues.
- Stepford Smiler: She has a tendency to admit depressing things in a cheerful tone.
- Super OCD: She does things, such as flicking light switches on and off, three times because she thinks that if she doesn't, Charlie will die. She gave Charlie vaccinations every month and she and him would also wear bubble boy suits every flu season.
- Tomboy and Girly Girl: Girly girl to Mrs Mac's tomboy.
- Vitriolic Best Buds: While she refers to Mrs Mac as a "horrible, horrible woman" and even tries to kill her in her sleep at one point, she also sincerely considers them to be great friends.
Uncle Jack Kelly
Charlie's uncle (the brother of Charlie's mother Bonnie) and a lawyer.
- Amoral Attorney: Jack is the gang's go-to attorney though a rather bad one. It's obvious to the audience that something's not quite right with him, every time he appears on screen.
- Black Comedy Rape: It's strongly implied that he molested Charlie or exposed himself to him or something that has caused Charlie to be extremely wary of him.
- Cloud Cuckoolander: Pretty much runs In the Blood for the Kelly family. Special attention goes to his obsession with the size of his hands.
- Compensating for Something: His self-consciousness over his small hands causes him to edit in different, larger hands in all pictures of him, while his public access TV show uses creative camera angles to avoid showing his hands as much as possible.
- Creepy Uncle: Uncle Jack is a deeply unsettling man. He's always touching people, he's obsessed with hands (he feels his own hands are too small) and he is all but outright stated to be a pedophile interested in young boys. When Dee declares she's kidnapped some kids (by accident) he immediately leaps into action with solid creepy advice.
- Noodle Incident: Whatever he did to Charlie as a kid has yet to be elaborated on.
- Omnidisciplinary Lawyer: Jack is stated to specialize in state and constitutional law, but the Gang comes to him for divorce issues and the McPoyle-Ponderosa trial... all of which he completely botches because he's totally unfamiliar with the relevant laws and has never even practiced in a courtroom before.
Mac's father, a convicted felon. He is tall and has numerous tattoos and a generally intimidating appearance because he never blinks. Possibly due to his past imprisonment and intimidating presence, he is one of the few people the Gang does not immediately try to manipulate or exploit.
- Abusive Parents: Was emotionally distant towards Mac while he was growing up, and only ever acknowledged him to insult or belittle him, causing Mac to desperately crave his approval. While Luther has genuinely made several attempts at reconnecting and improving his relationship with Mac, the Gang inevitably ends up screwing it up.
- The Atoner: Once released from prison, he goes to apologize to all the people he's wronged.
- Beard of Evil: Subverted. In a flashback where he doesn't have the beard, he's more unambiguously evil.
- Bi the Way: Was married to Mrs Mac and has slept with Charlie's mother, but was in a long term relationship with the crime lord Eduardo Sanchez. Bonnie recounts being in a threesome with the two of them that ended in her getting pushed off to the side while they finished together. Naturally, Mac futilely tries to spin this into Luther's way of enforcing his masculine dominance over Eduardo rather than admitting his father's bisexuality.
- Boomerang Bigot: Does not approve of his son's sexuality despite his own relationship with Eduardo Sanchez.
- Creepy Monotone: Rarely raises or inflects his soft but raspy voice, usually relying on his eyes to do the emoting for him.
- Death Glare: His default expression. He himself remarks, "I don't blink."
- Even Evil Has Loved Ones: Shown to genuinely love his son pretty much every time he appears. The only problem is that Mac is such an idiot that he constantly ruins his attempts at reconnecting with him by extending his prison sentence. Even then, Dennis eventually reveals that he had sent Mac countless letters from prison that he (Dennis) had destroyed before Mac was able to read.
- Failure Is the Only Option: He and Mac will never be able to reconnect with each other as father and son, despite both of them wanting to, as the Gang's actions will inevitably end up getting him arrested by the end of the episode.
- Hazy Feel Turn: It'd be a stretch to call him a good guy, but he went from a villainous and dangerous criminal to a guy who wants to set his life straight and make amends with all of the people that he feels he has wronged.
- I Am A Humanitarian: When he first meets The Gang, he seems oddly intrigued by Dee's hair, playing with it in his hands without saying anything. Dee is understandably creeped out, but she somehow twists this into thinking that Luther wants to eat her.
- Icy Blue Eyes: As Charlie points out to Bonnie.
- I Want Grandkids: Or very specifically, grandsons.
- Jerkass Ball: He's notably more openly hostile toward his son (and more talkative in general) in "Mac Finds His Pride", where he outright states that the only value he sees in him is his ability to give him a grandson. This is in stark contrast to his previous appearances, where it is always made clear that, while cold and abrasive, he genuinely loves Mac.
- Jerk with a Heart of Gold: He has a shady past and is quite blunt and rude, but he genuinely loves his son. In "Dennis Looks Like A Registered Sex Offender," Mac calls the cops on him because he thinks his father is on a murder spree that will end with him and Charlie. It turns out that Luther actually got arrested for violating his parole: he's not supposed to leave the state, but had purchased plane tickets for himself, Mac and Charlie to visit the Baseball Hall of Fame. Even after getting out of jail again, he writes Mac a letter saying he still loves him and that he's trying to learn to forgive him.
- Knight of Cerebus: Played with. While he's incredibly intimidating and rarely given jokes while on screen, he never actually does anything to make the show darker than it normally is. The Gang believes him to be this, however, causing them to freak out whenever he's involved in an episode's plot.
- Red Herring: As an incredibly scary career criminal, the Gang constantly suspects him of doing dangerous activities. Every episode he appears in inevitably reveals this to not be the case.
- Strong Family Resemblance: With his hair slicked back, Mac looks a lot like him.
- Tattooed Crook: He has quite a few tattoos.
Mrs. "Mac" McDonald
Mac's mom. She is usually seen smoking and watching television on the front porch of her home. She is extremely apathetic, demonstrated by her falling asleep at her son's "funeral" with a portable TV on her lap and remaining the same as usual when Luther is out on parole, and she often communicates with minimal words and unenthused grunts, which Mac serves as translator for.
- Abusive Parents: Openly rude and uncaring towards her son. Mac is so accustomed to her behavior that he has trained himself to interpret her agitated groans to mean whatever words of approval he currently wants to hear.
- Berserk Button: Being woken up, as Mrs Kelly found out to her detriment.
- Gonk: Something of an Informed Deformity. While she is a generally unhealthy and unhygienic woman, all of the members of the Gang besides Mac treat her as though she is The Grotesque, with Dennis going as far as to say that she is disgusting just to look at.
- Hidden Depths: She's very handy and good at fixing things.
- Jerkass: Has no problem with telling her son that she doesn't like him to his face.
- Must Have Nicotine: She's literally never seen without a cigarette in her mouth.
- Odd Friendship: With Bonnie Kelly, after some initial difficulties that involved Mrs. Mac strangling her a tad.
- Racist Grandma: She bonds with Bonnie Kelly over their mutual racism.
- The Stoic: "Irritated" is basically her only emotion. A flashback to Mac's childhood shows her acting and speaking in a much more normal fashion, suggesting that old age has caused her to stop caring even more than she already did.
- Tomboy and Girly Girl: Tomboy to Mrs Kelly's girl girl.
- The Unintelligible: Much of the time she communicates in grunts and coughs, which Mac then translates.
- Vitriolic Best Buds: Constantly fighting with Bonnie Kelly, but doesn't actually seem to mind having her as a roommate.
- The Ace: A true jack of all trades, he is shown excelling at everything that Mac struggles to do.
- The Alcoholic: The Gang notes he always he has a beer in his hand. This later causes him to die abruptly.
- Awesomeness by Analysis: When confronted by two thugs, he successfully pulls off an "ocular-patdown".
- Badass Gay: Everyone in the Gang except Mac finds his genuine badassness and being open about being gay to be very refreshing over Mac believing he's the former with little reason and loudly condemning the latter in spite of himself.
- Country Cousin: He's nick-named "Country Mac" because he's Mac's cousin from the countryside.
- Death by Falling Over: He dies from his motorcycle falling over at low speed.
- Dropped a Bridge on Him: He falls off his motorcycle and dies. Despite all of his larger than life badassery, his death was incredibly abrupt and anticlimactic.
- Due to the Dead: Subverted. Mac tries to get the Gang to spread his ashes in the countryside. Frank just dumps the ashes down Paddy's toilet.
- Foil: To his cousin, Mac. He is reckless, tough, confident but not cocky, religious but tolerant, and open about his sexuality.
- God Is Good: Believes in God for the good things he does, contrasting The Fundamentalist Mac.
- Good Counterpart: He's basically what Mac could be if he actually got his act together and made something of himself.
- Improvised Weapon: When a black-belt knocks out his cousin, he uses his shirt to strangle him.
- Manly Gay/Straight Gay: He admits he's at the bodybuilding competition to pick up some bodybuilders.
- Mellow Fellow: Remains calm and cool even when performing death-defying stunts.
- Mr. Fanservice: He's good looking and we get to see him shirtless.
- Nice Guy: Very easy-going, gets along well with the Gang, and doesn't even bat an eye at his cousin's rude behavior.
- Only Known By His Nick Name: We never get to know his actual name.
- The Stoner: Shares some weed with the Gang at the planetarium.