Note: If a series has a Main page, create a new subpage for Tear Jerkers rather than listing it here.
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The otherwise Squickful yaoi manga Boys Next Door pulls out all the stops angsty past-wise, hearing one of the main characters talk about being abandoned by his mother at a carnival. ("The jester's giving away balloons!"... "Mom, is there no balloon for me because I'm a child nobody wants?") It's supposed to be his Start of Darkness more or less but comes across as perfectly horrible.
The final episode of Dog Days: Shinku has to return to his world, much to the sadness of some of the people of Biscotti, especially Princess Millhi, who shares a tearful goodbye with him. But, there's a condition where Shinku can return anytime everyone wishes.
Tatsunoko's Hakushon Daimao, despite being a slapstick gag-comedy series, had a tear jerker in the final episode, where Daimao and Akubi-chan are forced to leave Earth for 100 years.
The ending of the Girls Love manga Honey Crush by Asu Tsubaki. Mitsu and Kyouko finally admit their feelings for each other and immediately afterwards, Mitsu finally goes to heaven, leaving Kyouko alone.
Even the short-lived Ane Doki managed to deliver some of these when in it's final lap. After knowing that he and his father are going to move to Hokkaido, which would mean his separation from the Hajiwara siblings, Kouta ends his dinner the most normal way possible, then go upstairs alone, shuts himself in his room, and completely breaks down.Even though Natsuki would annoy him quite often for being spoiled, aloof and nonsensical, he finally is accepting that he really loves her. Sound extreme Narm at first, but in fact is really relatable. Kouta is just thirteen years-old, and Natsuki is his first love, and this is going to be his first heartbreak. Everybody went through this one day.
Blue Exorcist starts out with the protagonist's adoptive father, Fujimoto, committing suicide to prevent Satan from taking him away. Later on, he and his brother find Fujimoto's familiar, a cait sith named Kuro, who has gone beserk upon hearing about his death. He refuses to accept it until the protagonist head butts him and offers friendship. Kuro breaks down into tears as he realizes his friend is truly dead.
Episode 10 of Hyperdimension Neptunia is pretty somber throughout due to Peashy having been turning into Yellow Heart and Eden trying to take over due to brainwashing. Plus the fact that Neptune, NEPTUNE; the 4th Wall Breaking, Gamer Addict, Goof Off, and least serious of any of the CPUS; is depressed and dead serious the entire episode, even when she's not transformed; is a dead give away that things are bad.
Though it all comes to a head at the end where the producers essentially took what was a Crowning Moment of Heartwarming from H.N. Victory and turned it into one of the saddest scenes in what is supposed to be a COMEDY. It starts with Transformed and Brainwashed Peashy beating on Neptune. In the end Anonydeath is stopped and Peashy is freed from Eden control...but Peashy doesn't remember ANYTHING, not even Neptune. Plutia then has to take the still amnesic Peashy home; and Neptuna arrives just before they go to say goodbye to Plutia and give Peashy a gift: "Nep's Pudding." Peashy still doesn't remember and Neptune smiles to say that it's the most delicious thing in the world. A few moments later, Peashy remembers and says "Neptuna!" right before she and Plutia disappear and go back to their dimension. Cue an incredibly sad insert/ending song with a very somber credits scene that ends with dolls of Neptune and Peashy holding hands. The song ends as Neptune looks through Peashy's drawings, starts to cry and just says, "P-ko," as the episode concludes. Keep in mind that this show is a Comedy and it just makes the fact that the creators were able to pull off such an effective and emotional scene that much more impressive...and make these moments that much more sad.
Remi (Ie Naki Ko), which became popularized in Latin American countries in the 80s, was an unending sobfest, but standing out was the scene in which the performing monkey dies on the the snowy streets. See it here. (Audio in Spanish)
Mahoutsukai Sally. After spending the entire series making friends in her school, Sally is forced in the end to reveal her powers to put out a fire. Day saved... except, because people now know she's a witch, she has to wipe everyone's memory and never return.
Osamu Tezuka's short films, despite usually not having any dialogue, frequently become this. M Mermaid is about a boy who falls in love with a mermaid that everyone says doesn't exist.
Korean Web ToonMy Young Cat And My Old Dog is made of tearjerk moments, especially considering it's at least partially true: the author does indeed have a young cat that she spared from euthanasia at the shelter she works at by pretending it was put down, then paying for its vet bills and a very, very old dog she's had since childhood ("if you were a human, you'd be my younger teenage sister, not an old grandma").
Ten, the series to which Akagi is a prequel, proves that author Fukumoto Nobuyuki loves bringing his characters down (see also: Kaiji). In the end volumes, Akagi (who, by this point in his life, is quite the mentor to the main characters), a terrifyingly skilled mahjong player armed with his considerable wits, unstoppable will to win, and preposterous luck develops Alzheimer's. In his early fifties. Akagi decides that this is a Fate Worse Than Death and that it's Better to Die Than Be Killed by a disease that will eventually make him into an empty shell of the man he is. So Akagi calls upon his closest friends to talk with them about his death, his life philosophies, and so on...hooked up to assisted suicide machine. The very last page of Ten is a shot of Akagi's headstone, which is covered with tributes to the legend himself and considerably damaged due to aspiring gamblers wanting a little bit of his talents.
Suki na mono wa Suki dakara shoganai or Sukisho has quite a few.
Episode ten reveals that both Sunao and Sora were kept in a laboratory as children and physically/mentally abused. To top it all off he was left behind after Sora was mind controlled into letting go of him and it has been suggested specifically in the manga that the abuse worsened to rape.
The scene when Shinichirou allows Sora to stab him Nanami's reaction was devastating as was Sora's
Another tear jerking moment was when Sora faces up to his fear of Aizawa and goes to save Sunao and when Sunao trips over he promises to never let him go again
Witchblade. Oh God, Witchblade. Anything involving the Child Welfare Agency taking Rihoko away after finding her real mother or Masane's body slowly breaking down due to overuse of the upgraded Witchblade qualifies.
Probably one of the most heartbreaking moments is in the penultimate episode where Masane eats a meal Rihoko made for her before heading off to her final battle (and almost certain death,) only to discover that she's lost her sense of taste.
Hisae Iwaoka's One Shot "White Clouds" does it in an unusual way. Told from a dog's point of view, it narrates the life of an old couple and their dog. The grandma has passed away time ago and the old man and his dog realize that the same fate is coming closer to them. If by the end of the 16th page you haven't felt moved at least, you seriously need to start looking for your soul.