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Tear Jerker: My Neighbor Totoro
My Neighbor Totoro/Tonari no Totoro is about as uplifting as you can get in anime, after all, it is mainly on the opposite scale of Grave of the Fireflies, but the scene where calm, level-headed Satsuki breaks down sobbing and asking what she'll do if her mother dies jerks every heartstring this troper has. Seeing Mei lost and crying for her sister is no emotional picnic, either. Also, even though they don't need him anymore, the knowledge that they never see Totoro again after the end of the movie is bittersweet to the taste.
Oh god, that scene made my eyes fill up. Nanny's attempts to comfort Satsuki to no avail also add to the tearjerker factor.
When Kanta tells Satsuki that they found a sandal in the pond, and she runs herself nearly to total exhaustion trying to get there.
