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Tear Jerker: Honoo No Alpen Rose
A good part of the story, with Hans's Heroic Sacrifice as a huge point.
Also, Leon finding out that his parents definitely are dead, and when Johan and Liesl tell Jeudi that the search for Lundi has been called off, which almost sends Jeudi towards the Despair Event Horizon.
Jeudi: "No, I'm not Alicia. I'm Jeudi! Lundi gave me that name!"
Chapter 15 of the manga is a giant tear jerker, what with Jeudi and Leon finding Jeudi's dad Friederich... only to lose him forever.
