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Tear Jerker: Binbou Shimai Monogatari
The last episode practically clubs you over the head with tearjerkiness and the makers don't eschew using a cliche or two. Still, the two sisters' characters somehow hold it together, making the series quite an emotional rollercoaster ride.
I'm a cynical little bastard, and I still started sobbing at just one line: "It wasn't looking at the dandelions that always made Mom smile. She was... looking at me."