Tear Jerker / Karin

• Elda faces this in both the anime and manga. In the anime she was forced to drain her lover blood in order to gain strength to escape from with human with him temporary forgot their love for a moment as the result and stabbed her while in the manga she is too late at reviving James from his sleep and he dies as the result.
• Carrera's father lost his will to live after her mother Cecilia passed away and staved himself to death rather than live on in the world without her.
• The end of the manga. Not only does Karin's older brother Ren wipe all her memories of her family but he does it with his last and only sign of brotherly affection. A pat on the head, because 'you don't like it when I'm rough, do you?' And we learn that all those times he gave her noogies were to help the memory wiping process and her family was planning this from the start because she wasn't a normal vampire and they wanted her to have a normal life in the end. Which they could never give her. And then, on top of that, we get the most bittersweet moment when Usui Kenta asks Karin if she remembers her family and she replies 'I don't have a family' while crying without knowing why, making Kenta cry as well—and then, he finally proposes making it wonderful and painful at the same time.
• Kenta's father Shuusei reappears in his life, clearly uncomfortable but seeming like he wants to make things work. However, the audience knows he only showed up because he had a falling-out with his new fiancée. Ultimately he decides it's better to make things work with her and their unborn child rather than re-insert himself into the lives of a wife and son who had already moved on without him. He apologizes for reopening their wounds, and promises they won't see him ever again. Half a page is dedicated to a close-up on Mrs. Usui's eyes...as they half-lid in disappointment.
  Kenta: Dad? ...bye.
  Shuusei: [without looking back] Yeah.
  • Now consider just why he had nothing to do with them for so long. It wasn't by choice. Fumio got pregnant in high school, which enraged her mother so much that she threatened Shuusei's life if he ever set foot near her again. But that wasn't enough: She tried to force Fumio to abort Kenta, and when Fumio refused, she beat the poor girl senseless in an attempt to make her miscarry. And when Kenta was born his grandmother redirected her fury at him, hating him for his scary expression, which, of course, she blamed on Shuusei. The abuse was so violent that when Kenta was in high school Fumio ran away with him to a different city - which, of course, she blamed on Shuusei, who hadn't been in Kenta's life for fifteen years at that point. And despite all of that, when Kenta and Karin's daughter Kanon is born, guess who Kanon showers with affection whenever they meet. Shuusei will never meet his granddaughter for as long as he lives, and the woman who, by all rights, would have rather she never existed gets to be a part of her life instead.
• Anju awakening as a vampire, leaving her life with Karin behind. The poor girl breaks down into tears after hearing an Innocently Insensitive "congratulations" from Karin, and she cries for the rest of the night. The morning afterward Karin realized the implications when she was expecting to see Anju but because of her vampire awakening Karin would never see her in the morning ever again, Karin breaks down herself and her loneliness among her own family worsens.

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