The death of Mamiya's brother, Kou during her introductory arc. And oddly, during the same arc, the way in which the Wolf Fang Clan mourns for the loss of its members is actually quite touching.
Kenshiro taking Taki home, shot to death for stealing water for his adoptive mother, and her anguished cry "He was only seven years old!" will likely make you want to pop the heads of Jackal and his band of bastards yourself.
When Bat's adoptive mother Toyo is killed by the impact of a stick of dynamite thrown away from a terrified little boy that it was tied to via Jackal. Even moreso heartbreaking in the manga when he calls her "Mommy" for the very last time as she dies with a warm smile.
The final three days of Rei's heroic life... oh God.
Rei's death: He was already dying in absolute agony because of Raoh's attack, but then he undergoes Toki's even more painful treatment, which is so painful it turns his hair white, just so he'd have his strength back and a little more time to fight Judah. And the reason for fighting Judah? Just to avenge poor Mamiya's honor. Kenshiro himself says that of all the men he's met, Rei's the only one that was his true friend.
If you thought a rock guitar theme cannot make you cry, you have not heard Asunaki Tabi yet. The most heartbreaking uses of this song were when Shuh wept in the graveyard of the children murdered by Souther and when he himself was tortured and murdered by said monster of a tyrant.
Fudoh's battle against Raoh had "crying time" written all over it from the start. Raoh, having felt fear when Kenshiro manifested Musou Tensei before him, concludes he needs to purge himself of all fear, and to do it he must first face the one man to make him feel fear for the first time: Fudoh. Raoh kidnaps Fudoh's adopted children and threatens to kill them if Fudoh does not face Raoh, and Fudoh must break his vow of peace to face him. Raoh demolishes Fudoh, but Fudoh refuses to give up and actually instills fear in Raoh by showing him how hopeless it is for him to fight without love and sadness. And then Fudoh ends up shot fatally with an arrow fired by Raoh's henchmen, defying Raoh's orders. Fudoh then declares that Raoh lost to him, and that as long as he continues to be oblivious to sorrow, he will continue to live in fear and never, ever defeat Kenshiro. Then he dies surrounded by his children, all crying for their loss, as a Really Dead Montage of Fudoh's life begins to play with the first ending theme in the background. SNIFF.
The death of Juza the Cloud.
When Asuka, Ein's adopted daughter, was asked why she is not crying at her father's funeral, she replies "If I cry, Daddy won't be able to rest." Kenshiro hugs the brave little girl with warmth and kindness and weeps Tender Tearsof sadness in her place.
Actually, Fist of the North Star is able to combine a few of these with the raw badass of the characters to be a Manly Tear Jerker series. There are a few, generally involving the deaths of major villains. Shin, declaring his love for Yuria even as he dies from Kenshiro's techniques and throwing himself from his throne room is an early example. One of the most effective involves the death of one of the protagonists, however. The battle between Raoh and Toki ends as Toki, who has been dying of an illness makes a last, desperate series of attacks in order to try to kill Raoh, his older brother. As the fight goes on, Raoh realizes that Toki's dying body means that Toki has no chance to win, but continues to fight regardless, and Raoh himself begins to cry even as he continues to fight, out of love for his younger brother, and because the destiny of their style makes a tragic fate such as Toki's unavoidable. The title of the episode that ends the fight says it all: "Farewell, Toki! The Tears Fall Only Once!"
There's more to it: Turns out that part of the reason this is happening is that while growing up, Raoh had made Toki promise to stop him were he to go down the wrong road, and had previously scolded Toki for crying.
The ending credits of the movie, in which Kenshiro imagines himself walking through a beautiful forest and seeing Yuria happy, only to have everything fade back to the desolate nuclear wasteland it all really is.
Somewhere around half the cast is composed of tragic heroes.
The murder of Ryo, an innocent little boy, by Souther's poisoned bread in the original manga and the first Raoh Den film. Watching a massive warrior weeping with his beloved baby son limp in his arms, you'd either have to be as kind as Kenshiro or as evil as Souther if you believe the tyrant deserves any forgiveness.
The undisputed champion of tear-jerking deaths in this series is Rei. His death is SO important, it's even used to signify the end of the second part of the first anime series.
Shuu's death was made into an even greater Tear Jerker in the first Raoh Den movie, as it's accompanied by Soundtrack Dissonance with the song "Where The Lights Are".
Kenshiro's long, echoing Say My Name cries really drove it home. And then Shuu lasts just long enough to see Kenshiro as an adult. Cue Kenshiro being the most pissed off he's ever been.
Kenshiro Den has one of the most devastating ones in the entire franchise: Yuria, dying of radiation sickness, reveals to Kenshiro that she is pregnant with Kenshiro's child. The big man himself lets the waterworks flow at the revelation.
Jagi Gaiden can best be summed up as one long Tear Jerker after another from start to finish. From seeing Jagi as he was, his relationship with Ryuken, Anna's death and Jagi's reaction to it, Ryuken's sorrow of what Jagi had become, Jagi's final moments looking back on his miserable life, Kenshiro's anguish over having killed Jagi despite everything he did, and Jagi possibly reuniting with Anna in death Honestly, it's hard not to weep at how thoroughly Jagi's life has been screwed by both his own actions and bitter fate.
The fact that this manga could make you sympathize with Jagi of all characters is saying something.
In a rather tasteful use of drama by Toei Animation, Kenshiro, after crossing Raoh's battle aura, tells him how much he and Toki admires him and how the feeling will never goes away from his heart, he full-blown sheds his Manly Tears in this fight. Who else wouldn't?
In the same episode, after Yuria tells Raoh of her fate (by radiation sickness like Toki's), he sheds tears of his own (again), mourning of her eventual fate and deciding not to sacrifice her to obtain Muso Tensei, but achieving it by the sadness that fills him with this revelation.