Note: If a series has a Main page, create a new subpage for Tear Jerkers rather than listing it here.
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A-H
The otherwise Squickful yaoi manga Boys Next Door pulls out all the stops angsty past-wise, but hearing one of the main characters talk about being abandoned by his mother at a carnival downright made this troper tear up. ("The jester's giving away balloons!" comes to mind... "Mom, is there no balloon for me because I'm a child nobody wants?") It's supposed to be his Start of Darkness more or less but comes across as perfectly horrible.
The final episode of Dog Days: Shinku has to return to his world, much to the sadness of some of the people of Biscotti, especially Princess Millhi, who shares a tearful goodbye with him. But, there's a condition where Shinku can return anytime everyone wishes.
The ending of the various incarnations of A Dog Of Flanders is usually considered one of anime's top Tear-Jerkingest moments. Other World Masterpiece Theater series tend to be loaded with these as well.
Tatsunoko's Hakushon Daimao, despite being a slapstick gag-comedy series, had one heck of a tear jerker in the final episode, where Daimao and Akubi-chan are forced to leave Earth for 100 years.
The ending of the Yuri Genre manga Honey Crush by Asu Tsubaki. Mitsu and Kyouko finally admit their feelings for each other and immediately afterwards, Mitsu finally goes to heaven, leaving Kyouko alone.
Even the short-lived "Ane Doki" managed to deliver some of these when in it's final lap. after knowing that he and his father are going to move to Hokkaido, which would mean his separation from the Hajiwara siblings, Kouta ends his dinner the most normal way possible, then go upstairs alone, shuts himself in his room, and completely breaks down.Even though Natsuki would annoy him quite often for being spoiled, aloof and nonsensical, he finally is accepting that he really loves her. Sound extreme Narm at first, but in fact is really relatable. Kouta is just thirteen years-old, and Natsuki is his first love, and this is going to be his first heartbreak.Everybody went through this one day.
I-L
Remi (Ie Naki Ko), which became popularized in Latin American countries in the 80s, was an unending sobfest, but standing out was the scene in which the performing monkey dies on the the snowy streets. See it here. (Audio in Spanish)
Oh believe me, there's a scene that either equals or tops it. And that one is Remi's enormous Heroic BSOD once he learns of the death of Vitalis. Seeing Remi cry and scream "My master! He's dead! My master's dead, dead, dead!" STILL makes this troper cry like a Magdalene. Watch it here (it's in Spanish too)
M-P
Mahoutsukai Sally. After spending the entire series making friends in her school, Sally is forced in the end to reveal her powers to put out a fire. Day saved... except, because people now know she's a witch, she has to wipe everyone's memory and never return.
Osamu Tezuka's short films, despite usually not having any dialogue, frequently become this. M Mermaid is about a boy who falls in love with a mermaid that everyone says doesn't exist.
Q-T
Ten, the series to which Akagi is a prequel, proves that author Fukumoto Nobuyuki loves bringing his characters down (see also: Kaiji). In the end volumes, Akagi (who, by this point in his life, is quite the mentor to the main characters), a terrifyingly skilled mahjong player armed with his considerable wits, unstoppable will to win, and preposterous luck develops Alzheimer's. In his early fifties. Akagi decides that this is a Fate Worse than Death and that it's Better to Die than Be Killed by a disease that will eventually make him into an empty shell of the man he is. So Akagi calls upon his closest friends to talk with them about his death, his life philosophies, and so on...hooked up to assisted suicide machine. The very last page of Ten is a shot of Akagi's headstone, which is covered with tributes to the legend himself and considerably damaged due to aspiring gamblers wanting a little bit of his talents.
U-Z
Witchblade. Oh God, Witchblade. Pretty much anything involving the Child Welfare Agency taking Rihoko away after finding her real mother or Masane's body slowly breaking down due to overuse of the upgraded Witchblade qualifies.
Probably one of the most heartbreaking moments is in the penultimate episode where Masane eats a meal Rihoko made for her before heading off to her final battle (and almost certain death,) only to discover that she's lost her sense of taste.
Hisae Iwaoka's One Shot "White Clouds" does it in an unusual way. Told from a dog's point of view, it narrates the life of an old couple and their dog. The grandma has passed away time ago and the old man and his dog realize that the same fate is coming closer to them. If by the end of the 16th page you haven't felt moved at least, you seriously need to start looking for your soul.