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Familial Foe

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Some villains oppose not only one individual, but their entire family. This antagonism is passed from generation to generation, especially if said villain is immortal and the family is of a Heroic Lineage, with only its descendants having the power needed to defeat the villain. Often times children will take up their parents' work when they are retired or dead and defeat the Familial Foe in their name.

May overlap with You Killed My Father. Compare Feuding Families and Sins of Our Fathers. Not to be confused with Archnemesis Dad and Evil Matriarch, despite the names sounding similar.

The trope also occasionally applies to heroic characters who fight multiple generations of a villainous family.


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    Anime & Manga 
  • Vanica, the host of the devil Megicula, from Black Clover. With the power of her devil, she fought Noelle's mother Acier Silva and fatally cursed her. Over 15 years later, she fights Noelle, whose goals are to break the curse Vanica cast on her friend Lolopechka as well as avenge her mother.
  • Muzan Kibutsuji from Demon Slayer: Kimetsu no Yaiba brought a Hereditary Curse upon the Ubuyashiki Family, his distant relatives, that induces a disease that causes them to die young due to being a distant relative of the family before becoming the first demon. As a result, the Ubuyashiki Family have led the Demon Slayer Corps for generations to kill all his underlings and eventually Muzan himself.
  • JoJo's Bizarre Adventure: The series chronicle the exploits of individual descendants of the Joestar family and their battles with their family nemesis; Dio Brando.
  • Negima! Magister Negi Magi starts as the hijinxes of a Child Mage in training, but Negi ends up battling the Mage of the Beginning, like his father before him. In the sequel UQ Holder! set in an alternate future, it takes Negi's "grandson" Touta to take her down once and for all.

    Comic Books 
  • Batman:
    • The Court of Owls and its Long-Lived assassins are bitter enemies of Batman and his son, and menaced his father and more distant ancestors in the past.
    • Carmine Falcone, The Don, is a notable Batman foe whose crime family includes his three adult children, sister, niece, and nephew, several of whom antagonize Batman even after Carmine dies.
    • Abattoir is a Serial Killer who is obsessed with killing members of his large family (ranging from his parents and brother to an unborn third cousin), and very few relatives survive an encounter with him.
  • In the Belgian comic book The Prince of the Night, many generations of the aristocratic Rougemont family tried to destroy the titular Vampire Monarch Vladimir Kergan, only to find themselves powerless, forced commit Heroic Suicide to avoid becoming his thralls. Until the Thirties, when Impoverished Patrician Vincent de Rougemont enters the fray.
  • The Punisher: The Punisher fills this role toward various villainous families in comics written by Garth Ennis (who tends to avert Comic-Book Time).
    • Four generations of Cesares' (three of which are taken out in one massacre) clash with the Punisher in The Punisher MAX.
    • The Punisher kills the three Gnucci brothers in the opening issue of The Punisher: Welcome Back, Frank. The rest of that arc (and a few other comics) feature him clashing with the brothers' mother, uncle, and cousins.
    • In The Punisher Vs Bullseye: The Punisher has been killing members of the Patrillo crime family since the 1980s, and only a few (largely ineffectual) family members are left by 2006.
  • The Shade: The Shade is an immortal Anti-Hero who is constantly being attacked by the many descendants of the Ludlows, a family of murderers he killed in 1838. One Ludlow who sympathizes with Shade commits suicide because of his family's hostile reaction to this sentiment. By 2005, the Ludlows have nearly been wiped out by Shade, and the only three known survivors (one of whom is raised with no knowledge of the feud) leave him alone.
  • The Tomb of Dracula: The Van Helsing and Harker families have spent about four generations trying to kill Dracula for good, even as their numbers dwindle.
  • Wonder Woman: As there are several continuities where Wonder Woman fights alongside several generations of Etta Candy's family, Etta, and her children and grandchildren have found themselves fighting Ares and Circe.

    Films — Animated 
  • The Book of Life: Manolo, his father, and the temporarily revived spirits of his cousins and ancestors all battle the bandit king Chakal in the final act.
  • Coco: Twist villain Ernesto de la Cruz fights Miguel, his great-great grandparents, his great-aunt, his great-great aunt, and his great-great granduncles while trying to keep Miguel from leaving the Land of the Dead and poisoned Miguel's great-great grandfather while they were still alive.
  • The Incredibles: While Mr. Incredible is the hero who Syndrome really hates, he has no problem with targeting his nemesis’s wife and kids, and they gladly oppose him in turn.

    Films — Live-Action 
  • 3 Ninjas: The Big Bad of the first movie is a sworn enemy of both the eponymous brothers’ maternal grandfather (his former mentor, who hates him for turning evil) and father (a federal agent investigating him for arms smuggling). He sets out to kidnap the boys to get leverage against their father and grandfather, and ends up pretty frustrated with the boys due to how competent they are at fighting his men.
  • Big Jake: John Fain nearly kills Jeff McCandles, kidnaps his son, and demands a large ransom from his mother. Instead, she has her husband and other two sons go out to take Fain down, and they have some skirmishes throughout the movie.
  • Dead Silence: Mary Shaw murdered a young boy named Michael Ashen and her evil spirit has spent decades murdering four generations of Michael's relatives (including an unborn child) after Michael's vengeful father and brothers killed her.
  • Halloween: While the series is bogged down by Canon Discontinuity, one constant is the Serial Killer Michael Myers menacing relatives of the original Final Girl (who is his long-lost sister in some of the movies). Her children (three different kids in three different timelines), grandchildren, and adoptive cousins have all found themselves running for their lives from Michael.
  • Hellraiser: The LeMarchand/Merchant family are enemies of the Cenobites and seek to close the gateway to Hell, which he wants to be kept open. The Cenobites' first clash with a member of the family is in 1796, and the feud ends in 2127 with Pinhead's defeat.
  • In Johnson County War, hired gunman Hunt Lawton has been an enemy of the three Hammett brothers for many years before the movie's beginning, ever since he murdered Dale Hammett's grandfather-in-law. The old man is also the grandfather of the three brothers in the original novel.
  • The Hobbit: Azog the Defiler has sworn to wipe out King Thror, of Durin's line. In the Back Story he killed Thror and drove Thror's son insane, and is currently out for the blood of Thror's grandson and two great-grandsons.
  • Jeepers Creepers 3: The Creeper menaces the mother and niece of one of his previous victims, Kenny Brandon, due to a piece of his body being buried on their land and the Creeper wanting to eliminate anyone who might have obtained dangerous knowledge from the piece of his soul embedded in that body part.
  • ''The Legend of the 7 Golden Vampires:
    • The descendants of his old foe Dr. Van Helsing (who are constantly showing up in Dracula stories) fight the evil Count Dracula.
    • The 7 golden vampires clash with the eight grandchildren of two farmers who their army killed in the past. The grandfather got a Dying Moment of Awesome that struck back at the monsters, so they have cause to remember his family.
  • Nobody: As part of Yulian's vendetta against Hutch, he sends goons to attack Hutch's house while his wife and kids are there (although the goons don't specifically try to hurt his wife and kids on screen) and to kill or kidnap Hutch's father. In the climax, Hutch's father and brother help take out Yulian and his goons.
  • The Raven (1963): Dr. Scarabus was a bitter rival of the late Roderick Craven for decades and drove him to an early grave. During the film, he manipulates, kidnaps and threatens Roderick's son and granddaughter.
  • The Spiderwick Chronicles: Eighty years before The Film of the Book, the evil ogre Mulgarath menaced Arthur Spiderwick and his daughter Lucinda while trying to steal Arthur's research about the magical world. Decades later, he menaces the great-grandchildren of Arthur's brother.
  • Sundown: The Vampire in Retreat: The Van Helsings (yes, those Van Helsings), have spent over a century trying to kill Count Mardulak, who they view as an Always Chaotic Evil figure. Actually, Mardulak is The Atoner, although he's willing to admit that once he gave them a reason to chase him. When Robert Van Helsing finds him, he ends up being turned into a vampire and becoming a part of Mardulak's community, which is portrayed as a good thing.
  • The Texas Chainsaw Massacre: Most survivors of the Serial Killer Leatherface have to fight members of his Cannibal Clan family (brothers, grandfather, mother, uncle, nephew, daughter, etc), although the family tree has a lot of Canon Discontinuity.
  • Van Helsing: Nine generations ago, the Valerious family made a pact to kill Dracula, and only two of them remain alive to keep trying.
  • Wolves: A (possibly) single generation version with bad people on both sides appears. Connor is on bad terms with the three Wills brothers: he harasses, kills, and cannibalizes Carter Wills with little provocation and ran Wild Joe out of town years ago after blinding him him in one eye. Joe (who was run off for being Eviler than Thou to Connor) holds a grudge, and engineers a Long Game to kill Connor in revenge. The third brother, Larson, is too cowardly to fight Connor no matter how awful his actions are, but still dislikes him. The Wills' Tangled Family Tree (their second cousin is Connor's son) means that either they and Connor are Clashing Cousins or their familial feud with Connor goes back a generation further. If they aren’t Connor's cousins, then they are nephews of either John Tollerman (who fights Connor in the present) or John's late brother-in-law (who Connor still hates for keeping him and John’s niece Lucinda apart, regardless of whether their relationship was consensual).
  • Wrong Turn: Most of the films have survivors striving to kill multiple members of the Cannibal Clan, but Dale Murphy from Wrong Turn 2: Dead End stands out for killing or injuring villains from three generations of the family.

  • Accidental Detectives:
    • In Legend of the Gilded Saber, the Big Bad is primarily concerned with wronging Mike's uncle, but also clashes with Mike and his cousin during the novel.
    • Decades before Madness at Moonshiner's Bay, the Big Bad blackmailed Mr. Johnson into faking his own death while also threatening the lives of Johnson's children. He then tried to frame one of Johnson's nephews for the nonexistent murder, only to frame the other nephew by mistake. In the present, both nephews and one of Johnson's sons help bring the bad guy down.]]
  • Buffy the Vampire Slayer novels:
    • The Big Bad of Sins of the Father is a demon who has been a sworn enemy of the Giles family for fifty years. Giles's grandmother badly injured Malthus in one fight and subjected him to fifteen years of Forced Transformation into a crone after another encounter. However, he left her with twenty-five years of nightmares and the family hates him as much as he hates them. In the present, he sets out to mentally and physically break Giles as brutally as possible and then kill him. He nearly succeeds, but ends up dead himself.
    • In The Gatekeeper Trilogy, flashbacks show that Il Maestro and his rival, the far more benevolent, Medici Court Mage Richard Regneir tried to fight each other’s influence. Fulcanelli won the political battle, but after his fall from grace, he killed Richard’s wife and only failed to kill his son by chance. After Richard and his descendants become Long-Lived Gate Guardians, Fulcanelli spends a long time weakening dimensional barriers, making their jobs harder, while plotting to eventually kill the Regneir gatekeeper and bring about the apocalypse, while also getting his revenge on the family. He makes his attempt while Richard‘s grandson is dying and also targets Richard's young great-grandson.
    • In Tales Of The Slayer: The Code of the Samurai, Lord Asano views his living descendants (known as the Asano Living Clan) as a stain on the honor of his vampiric clan and is obsessed with brutally killing them, regardless of whether they're actively seeking battle with his undead clan or are trying to flee the country and forget he exists. Ultimately, this is his undoing, as the Asano Living Clan summon the Slayer for help and their leader helps her kill Asano by distracting him at a key moment.
  • Children of the Red King: Evil Sorcerer Count Harken Badlock becomes a hated enemy of the Red King and his wife and sister during the 12th century and marries the Red King's eldest daughter largely to spite his old enemy and corrupt members of the family. Harken is still endangering and corrupting descendants of the Red King's ten children when he finally gets his just deserts in the early 21st century.
  • In William Johnstone's Eagles series, Jamie Ian MacCallister becomes a mortal enemy of eight unsavory families, four of them by the time he turns fifteen, as a result of actions like marrying a girl against her father's wishes and wounding two brothers planning to rob and rape his foster parents. Most of the families are still seeking revenge when Jamie dies around the age of seventy (fortunately, there's no mention of them ever feuding with Jamie's many descendants afterward).
    They were the sons and grandsons and cousins of the Newbys, the Olmsteads, the Saxons, the Layfields, and the Bradfords. And they all, for various reasons, hated Jamie Ian MacCallister. Some of them hated him because their fathers had hated Jamie.
  • The Eyes of The Dragon: Every few hundred years, Flagg visits Delain, gets himself made the Evil Chancellor, and has any member of the ruling dynasty who gets in his way murdered or framed for murder.
  • Harry Potter:: Many wizarding families have been enemies with Voldemort across multiple generations, but in addition to being opposed by Arthur and Molly Weasley and their six children, Voldemort also had to contend with Molly's brothers (whom his men killed) during The Great Offscreen War.
  • InCryptid:
    • The Crossroads claimed the soul of the Price siblings' grandfather a long time ago, and their grandmother has been on a Roaring Rampage of Revenge ever since. Other family members also get involved sometimes, and the crossroads is happy to try and strike back at them.
      • After destroying the Crossroads in That Ain't Witchcraft, Antimony muses that she may be inadvertently responsible for its fixation on her family, and on sorcerers in particular, due to a Stable Time Loop.
    • In That Ain't Witchraft, James Smith's maternal ancestors have been dying as soon as their child turns 12 for many generations due to the Exact Words of a deal their forebearer made with the crossroads. James is out to destroy the crossroads even before learning this after they abduct or kill his friend when she tries to make a deal to end his Hereditary Curse.
  • Judge Dee: The Big Bad of The Chinese Bell Murders has spent decades framing, killing, and otherwise persecuting three generations of a family that he feels envious of.
  • The driving plot of The Lies of Locke Lamora is eventually revealed to be a scheme by the Gray King to wipe out Capa Barsavi entire family and estate in retribution for Barsavi killing his parents.
  • Meg Langslow Mysteries: The Pruitt and Dingley families (Small Town Tyrants who run Caerphilly and Clay counties, at least initially) both contain multiple unpleasant, if not outright criminal, members who Meg argues with or investigates. Downplayed, though, as few of them seem to take notice of their relatives' past antagonism with Meg even as the new family members become antagonists.
  • Peter and the Starcatchers: Eldritch Abomination Lord Ombra is opposed by four different generations (not all of them consecutive) of Peter Pan's allies, the Asters.
  • The Sackett Brand (by Louis L'Amour) has Big Bad Van Allen try to kill Tell Sackett to cover up his rape and murder of Tell‘s wife. Tell‘s oldest brothers and lots of cousins of varying degrees show up to oppose him. Allen is willing to have them killed too, but his men lack the ability to do so, and the combined might of the family easily defeats him at every turn.
  • Serge A. Storms: After Jim Davenport tricks Skag McGraw (an armed robber threatening Jim's baby daughter) into being killed by a defective car feature, Skag's brothers and cousins make repeated Avenging the Villain attempts on Jim's life throughout The Triggerfish Twist and Atomic Lobster, with Jim killing two more members of the family while Serge Storms defends him from others.
  • A Series of Unfortunate Events: Count Olaf spends all thirteen books terrorizing the Baudelaire siblings and once viewed their late parents as sworn enemies. He also kills a couple of distant Baudelaire cousins to further his plans.
  • Spy School: While Murray Hill is Ben's Arch-Enemy, he also fights Erica and her father, as well as her mother, sister, and grandparents in later books, and they come to hate each other.
  • Star Wars Legends:
    • Nom Anor and Warmaster Tsavong Lah from New Jedi Order, Lady Lumiya from Legacy of the Force, and Thrackan Sal-Solo from both series (as well as The Corellian Trilogy) are all evil people who have long-running and very personal feuds with the Skywalker-Solo clan (Luke, his sister and brother-in-law, his wife and son, and his niece and nephews). They target members of the family for violent death, The Corruptor efforts, or both.
    • Tales from the Mos Eisley Cantina: The Serial Killer Dr. Evazan once killed seven members of the Sillizzar family, and six more family members are out to put an end to his murder spree.
  • The Twilight Saga: Aro, leader of the vampire government, is out to destroy the Cullen Family (although, unlike most examples of the trope, they are an adoptive family), except for their most talented members, who he wants to forcibly recruit. The whole family comes to loathe him as a result of his actions.

    Live-Action TV 
  • An Evil vs. Evil version occurs in Breaking Bad, where Gus Fring spends decades scheming to bring about the deaths of the nephews and grandson of his rival drug lord Hector Salamanca (who killed Gus's best friend and possible lover) before killing Hector himself.
  • Cobra Kai: Each Cobra Kai leader is a former enemy of Daniel LaRusso, and while Johnny Lawrence is well-intentioned and has few problems with Daniel's wife and kids, the same can't be said for John Kreese and Terry Silver (particularly the latter). They might not specifically seek out fights with the LaRusso kids, but Samantha is quick to help out her father and suffers a lot due to The Corruptor actions of First Kreese and then Silver making a lot of her classmates unstable and violent (something which her brother eventually gets caught up in as well). Daniel's future cousin-in-law also experiences a lot of harassment from Silver during the events of The Karate Kid Part III.
  • The Dukes of Hazzard: Small-Town Tyrant Boss Hogg is constantly trying to con members of the Duke clan (his old rival Jesse Duke, five nephews and a niece-only three of whom appear in most of the episodes- and some distant cousins who appear in one episode) or frame them for his crimes. Even when Boss isn't directly out to get the Dukes, they still interfere with his money-making schemes out of a sense of justice or because It Amused Me. Boss Hogg and the Dukes have regular Friendly Enemies or Enemy Mine interactions, but always go back to fighting each other before long.
  • Fargo: Season Two: By the halfway point of the season, Mike Milligan is sending assassins after Floyd Gerhardt, her two surviving sons, and her eldest granddaughter as part of his efforts to take over their crime family's rackets.
  • Hatfields & McCoys: While Frank Phillips belongs to neither of the Feuding Families, he hates Hatfields more than some of the McCoys (who become his employers) do. A grandnephew of Devil Anse shoots Frank in the leg while he is serving an eviction notice, and Frank kills that man and his brother in self-defense. Anse then tells Frank to get out of town or risk retaliation. He sticks around and is happy to take Bounty Hunter jobs to try to kill or arrest Anse’s sons, brothers, nephews, cousins, and uncle, succeeding in many cases.
  • Game of Thrones: The Machiavellian Littlefinger remorselessly arranges for the downfall of Ned Stark (whose wife he lusts after and whose brother once injured Littlefinger in a duel) during the first season. In seasons 5-7, he puts one of Ned‘s daughters in an Arranged Marriage with an abusive rapist and later tries to turn her and her siblings against each other with his manipulations after she escapes and has to accept him as an ally.
  • Krypton: Brainiac and General Zod, both of whom are destined to become members of Superman's rouges gallery in two generations, end up battling against Superman’s grandparents and great-great-grandfather.
  • Power Rangers Mystic Force: The Master is a bitter enemy of Big Good Udonna and her whole family (her husband, son, late sister—before her death—, and niece).
  • The Secret Circle: In the books, Black John is an evil warlock who was part of the community that founded New Salem. Over the centuries, he has twice returned in an effort to make the descendants of his former allies bow down to his will, killing many of them when they refuse. His third attempt takes place when the children of many of his previous victims (and the daughter he fathered with one of the young witches he was manipulating) are teenagers, and they defeat him for good. In the TV adaptation, John Blackwell isn't immortal, but he still tries to corrupt the parents of many of the main characters in a quest for power, causing him to be hated by many of their grandparents, as well as the kids themselves when they find out the truth.
  • Supernatural: '
    • Azazel, the Yellow-Eyed Demon, is the demon who killed Sam and Dean Winchester's mother and gave Sam his special powers. The demon also killed their mother's parents and extended family, took their father's soul to hell (as part of a reluctant deal) and sent one of his demon minions to kill Sam's girlfriend Jessica in the same way that his mother died (after manipulating events to make them meet and fall in love in the first place) as part of his plan to corrupt Sam and turn him into the perfect vessel for Lucifer. The first two seasons follow the Winchester brothers on their quest to kill the demon, but his actions have a lasting impact on their lives that can be felt long after his death.
    • While Crowley is an occasional ally of the Winchester brothers, he's been an enemy to them, their mother, and their maternal grandfather and cousins (although they do reluctantly make a deal with him) over the show's run.
    • The demon Abaddon fights the Winchester brothers decades after trying to kill their paternal grandfather and ruining his life.
  • The Vampire Diaries: Damon Salvatore has spent about seventy years seeking revenge on the family of a Mad Scientist who experimented on him, sparing a survivor in each generation to give birth to a new generation of Whitfields for him to kill.

  • Titus Andronicus: Aaron the Moor makes it his mission to destroy his former captor, General Titus Andronicus, and Titus’s children, even though most of them oppose Titus at many turns.

    Video Games 
  • The original campaigns of Age of Empires III have three generations of the Black family facing their biggest enemies, The Circle of Ossus, a powerful N.G.O. Superpower with enclaves in many cities whose leaders want to Take Over the World.
  • Castlevania: Hunting monsters is the Belmont family hat, and each game features a Belmont taking on Dracula with the help of various allies.
  • Mundus, the Big Bad of Devil May Cry, has been a longtime enemy of Sparda and his bloodline, fighting not only Sparda himself, but also his sons Dante and Vergil.
  • The Fell Dragon Grima from Fire Emblem: Awakening. It tried to destroy the continent of Ylisse but was defeated by the First Exalt and the Divine Dragon Naga. Centuries later, it is resurrected by the Grimleal and faces off against Chrom, a descendant of the First Exalt, and Lucina, Chrom's daughter from the Bad Future.
  • The Legend of Heroes: Trails of Cold Steel: Ishmelga, the curse of Erebonia, has a long-lasting history of trying to manipulate Emperor Dreichels and his descendants, and this includes Dreichels' reincarnation; Gilliath Osborne (who becomes his "master" and his Divine Knight), as well as Osborne's son; Rean Schwarzer. It's revealed in Cold Steel IV that Osborne made a pact with Ishmelga to save his son from a fatal injury, and desires to lose in battle so that he take Ishmelga with him and succeed in getting rid of the curse. By the end of the game, Rean defeats his father, and by extension, Ishmelga.
  • The Legend of Zelda: The incarnations of Demise's hatred, most notably Ganondorf, are fated to clash with those with the blood of the Goddess, ie. the Hyrulean Royal Family as exemplified by Princess Zelda.
  • Roger Retinz from Phoenix Wright: Ace Attorney – Spirit of Justice serves as this to Troupe Gramarye. Once a member of the show under the alias Mr. Reus, Retinz was exiled from the show after an accident while practicing, and came to harbor a deep hatred for the family as a result of this. In the second case, he attempts to frame Trucy Wright, the heir to the Gramarye name, for the murder of Manov Mistree, and has Trucy sign a rigged contract that would cause her agency to get repossessed by him should she be found Guilty. Eventually, Apollo Justice (unknowingly a member of the Gramarye family) is able to prove Trucy's innocence, and Retinz continues to curse the Gramarye bloodline both during and after his Villainous Breakdown.
  • In Rogue Legacy, you play as a generation-spanning family, with one descendant of each generation entering Castle Hamson to defeat the monsters that live there and fight the traitor inside, who is thus the enemy of everyone in the family tree. This traitor, Johannes, is actually the start of the family tree, and has been alive the entire time due to the fountain of youth.
  • Sly Cooper and the Thievius Raccoonus's Big Bad, Clockwerk, has been hunting down and killing the Cooper clan for centuries, to the point of turning himself into a literal hate-fueled Cyborg so he could go on living until the Cooper clan was completely wiped out.

    Web Comics 
  • In El Goonish Shive, "Not-Tengu" sets himself up to be this by threatening to kill all of Noriko's family.
  • Felicia, Sorceress of Katara: Count cla di Howler killed the titular character's parents, but he died of old age before she managed to properly take revenge. However, as a magi Felicia's lifespan could extend for centuries so she's settled for antagonizing his descendants.
  • Our Little Adventure: The Silverfronds royal family is Cursed to face the immortal Demon Lord Mortaridar every generation. Unfortunately, a third party's careless Wish releases Mortaridar from his extraplanar prison long ahead of schedule, when the current king is nowhere near a powerful enough Archmage to defeat him.
  • White Dark Life and its roleplays carry several examples:
    • Mysto to the Belnades clan.
    • Mysta to the Firecats (Blaze the Cat and her family).
    • Altair to the Astartes.
    • The Light Demons to the Dawns and the Caliburs.

    Web Original 
  • Whateley Universe: The maternal line of the Ferris family of Ferris Biochemical has been working to counter supervillain Deathmaiden's bioterrorism for about four generations, counting the latest of the line, Macrobiotic, who is still in high school as of 2006-2007.

    Western Animation 
  • Batman Beyond: As a younger superhero, Batman fought the Royal Flush Gang while Queen's father was its leader. During the events of Batman Beyond, he helps his protégé Terry fight the current gang, which includes Queen and her two children.
  • DuckTales (2017): Most of the recurring villains clash with Scrooge, his niece and nephew, his grand nephews and the occasional extended family member. No villain fits the role better than Bradford Buzzard, as he has spent decades engineering misfortunate events for family members, and hates the entire family and not just certain members.
  • Iron Kid: In his first attempt at world domination, the General was defeated by Marty's ancestor Eon. In the generations since, his followers have been killing Eon's descendants so that they can't face the general with Eon's Ancestral Weapon. Marty, the last known surviving descendant, gets his hands on that weapon and uses it to face the General upon his return.
  • Kim Possible: Dr. Drakken and Shego specifically target Kim Possible and her father with some of their schemes, but Kim’s brothers, uncle, and one of her cousins join in some of Kim’s missions to stop the two villains.
  • The Real Ghostbusters:
    • After failing to kill Ichabod Crane centuries before "The Headless Motorcyclist," the Headless Horseman/Motorcyclist has made regular attacks on Ichabod's son, distant niece, and other family members.
    • In "Scaring of the Green," every St. Patrick's Day where there's a full moon, the current head of the O'Malley clan is Dragged Off to Hell by a bog hound as punishment from a leprechaun who was vengeful after being robbed by a family member.