G Rated Drug / Western Animation

• In the 6teen episode "Over Exposed", Jude becomes addicted to Burger McFlipster's French Fries. He ends up with a major Balloon Belly and nausea in the end.
• All Hail King Julien:
  • Julien starts to act drunk without any substance intake when exhausted from hours and hours of partying, complete with a hangover the next day.
  • Party animal Rob turns one of Julien's parties into a rave by adding "witch doctor prescribed bone dust extract".
  • At one point, Horst, who is often seen drinking an unspecified Umbrella Drink, appears to be Drowning His Sorrows with them and very obviously becoming more and more drunk as the episode continues.
• The Adventures of Jimmy Neutron, Boy Genius: In the episode "Krunch Time", Jimmy attempts to create the perfect candy. When he succeeds, everyone else aside from Jimmy, who didn't have a piece, becomes quickly addicted to the stuff. At first, Jimmy is willing to take advantage of the situation to get favors in exchange for candy, but as they start get increasingly agressive and hooked on the stuff, Jimmy begins to realize how unhealthily it's affecting them, especially when his own parents get addicted too. Trying to cut them off cold leads the citizens of Retroville to riot, willing to imprison Jimmy to force him to make more candy for them. It's only when Jimmy adds some edible miniturized shock rays to the candy does he break them out of it, figuring the pain would override their pleasure. It works, though Sheen keeps eating more anyways.
  Sheen: Hey, Jimmy, that last batch was delicious! [zap!] Also incredibly painful. [zap!] Hey, do you guys smell smoke? [zap! Sheen starts patting his face] I can't feel my face! [zap!] How come everything looks blue? [zap!]
• The Amazing World of Gumball:
  • In "The Flower", Mr. Small drinks herbal tea that makes him act completely stoned, zone out, and even pass out. At one point, his eyes dilate while he lets out a "Woo hoo!"
  • In "The Flakers", Richard spends most of the episode high on anesthetics from the dentist, experiencing vivid hallucinations, even though real dental anesthetics are not hallucinogenic.
• American Dad!:
  • One episode has Steve get addicted to an energy drink called "Cougar Boost", and he starts acting like a twitchy junkie if he doesn't have any.
  • There is also the episode where Stan gets addicted to burn cream. More accurately, he needed to apply the cream to a burn on his penis and misunderstood his doctor's directions. This led to him masturbating for the first time in his life. His addiction was actually towards masturbating and using the application of the cream as an excuse to do it without him considering it a sin. Once he ran out of cream refills he eventually performed the act as is.
• An episode of Arthur featured a popular candy bar that's later subverted when it's revealed to contain not only radioactive elements, but a fictional chemical known as Tri-Enzomated Zorn Jelly which works like a real drug (directly affecting the brain chemistry to make the person consuming the candy bar extremely happy but making the consumer feel sad when the chemical wears off until they get more of it) and the in-show explanation on how said chemical works sounds like an extremely simplified way of explaining how real drugs work. This discovery prompts the candy to become illegal.
• Avatar: The Last Airbender: Sokka (and Momo) are high on cactus juice through almost the entirety of "The Desert". The cactus causes loopiness and hallucinations, and its effects last for many hours. This is actually Truth in Television: several species of cacti can cause hallucinations if consumed, most famously peyote.
• Batman Beyond:
  • "The Winning Edge" is actually an aversion of the "G-rated" part, as it features steroids (a "steroidal compound" according to Bruce Wayne's files on it) taken like nicotine patches via adhesive pads called "slappers". It turns out that they're based on Bane's Venom, which has rendered him a comatose junkie and invalid after decades of abuse. Terry is accused by his mother of taking the drug, but the test results prove that he's clean. To be fair, though, he only swipes a sample to investigate and shut down the source as Batman, and is only in trouble because his little brother is prying.
  • In "Hooked Up", the villain Spellbinder opens a VR arcade, where people can experience their greatest fantasies. The massive doses of endorphins released by living out these fantasies, however, make these simulators extremely addictive. As soon as people leave his VR machines, they experience intense withdrawal symptoms. He uses this to get people to steal and commit other crimes for him.
• Renuyu from the Batman: The Animated Series two-parter "Feat of Clay: Part 1/Part 2". Matt Hagen is shown to be violent and irritable when he runs out of it, and a goon seems to explicitly liken him to a drug addict, saying "Once they're hooked, they stay hooked." There's also the obvious subtext of Matt becoming so desperate that he agrees to perform increasingly shady and illegal acts just to get more of it. Since the purpose of the drug is to cover up Matt Hagen's deformity and make him able to work in show business, it combines drug addiction with plastic surgery addiction.
• Beavis and Butt-Head: Beavis's alternate persona, The Great Cornholio, is created due to a large consumption of caffeine. One episode has Beavis having a sugar crash and is given a powerful cappuccino to keep going (he was in a poetry night thing. Don't ask) and, in the movie, he downs a number of caffeine pills after a well-meaning old woman gives him some to help him (first to help with airsickness, the second after the bus driver kicks his ass).
• Bob's Burgers: Tina's addiction to coffee in "The Unnatural" is treated like this, with Tina adopting an aggressive new personality and experiencing vivid hallucinations when she goes into withdrawal.
• The Boondocks: The episode "The Itis" highlights the destructive effects of too much junk food (soul food) on the neighborhood and its citizens, such as people neglecting their jobs before eventually losing them, becoming morbidly obese, committing crimes to afford their sustenance, the infrastructures falling apart...
• Mira Nova from Buzz Lightyear of Star Command gains a power boost after absorbing nuclear energy in "Super Nova" but becomes addicted to it over time. Zurg attempts to exploit this, and weaponize the power boost, but that fortunately fails. Her father reveals that he's struggled with this addiction as well. She does get better in the end, but he warns her that in fact, she will never be completely free of the cravings for it.
• The Captain Planet and the Planeteers episode "Mind Pollution" has 'Bleeesss... I NEED Bleeesss...' It's explicitly called "a new designer drug" and kills a person who overdoses on it.
• Chip 'n Dale: Rescue Rangers gives us Monterey Jack, whose cheese addiction is often played like this.
• Clone High:
  • Parodied in "Raisin the Stakes: A Rock Opera in Three Acts", which revolves around Abe's destructive addiction to smoking raisins. After learning that you can't actually get high on raisins, the students decide to kick the habit for good and "smoke crack, instead!"
  • Another episode has Abe growing a crippling addiction to Staying Awake (so he can do elaborate favors for Cleo). Joan reveals she had a problem with the same thing, and once had to spend a summer at a "Sleep-Away Camp".
• Codename: Kids Next Door:
  • Numbuh 2 was once a chocolate sauce addict; he claims he's "off the sauce" in "Operation: S.P.A.N.K.E.N.S.T.I.N.E.", but the end suggests he might have relapsed.
  • Sugar and caffeine in general are basically this in general for the show, as drinking soda is illegal for anyone under 13 and the KND are often hired to smuggle it.
  • Numbuh 5 is implied to be a sugar addict. Her solo episodes are usually themed around candy and hunting for it against a rival. She has a secret stash of candy, has (albeit accidentally) gotten pseudo-high off coffee, and once passed out due to drinking several pounds of straight sugar! Numbuh 5's Distaff Counterpart rival, Heinrich von Marzipan, also seems to have an addiction and handles it far worse than the former.
• Dexter's Laboratory:
  • In "Dexter's Rival", in the end, Dexter has a toast with one of his inventions in which he pours root beer in a glass that's usually used for drinking liquor.
  • "Beard to be Feared" has Dexter getting roped into breaking up a band of flour smugglers.
• Double Dragon (1993), notable for having An Aesop at the end of every episode, has an episode that focuses on the Shadow Master producing a designer drug, known as Euphoria, which turns users into wide-eyed, green-eyed zombified people. Presumably in attempt to avoid portraying real drug abuse methods, the green liquid Euphoria os not ingested nor injected, but rather poured onto bare skin, though it is often applied this way to the forearm. Later on, the Shadow Master is back in the business, selling RPM.^note Stored in glass balls which are broken and the drug inhaled. Billy looks horrible when forcibly dosed. The drug acts very much like steroids.
• An episode of Doug centers on Nic-Nacs, a legal, gum-like "relaxant" that is clearly tobacco in all but name (its main ingredient was "nicoglutenousmonopexterate"). The episode is a pretty heavy-handed screed against the tobacco industry for a kids' show. The episode also features Mr. Bluff knowingly and intentionally marketing that product to kids, therefore cementing his status as a Corrupt Corporate Executive.
• Ed, Edd n Eddy:
  • In the episode "Over Your Ed", the Eds are making energy drinks to sell to the customers for Eddy's latest scam, and Eddy just pours a large bag of sugar into the mix when Edd isn't looking. When Edd takes a sample, he spends the rest of the episode hopped up on a sugar rush, acting much more cheerful and manic than usual. By the end of the episode, Edd is even shown to be "hung over", wearing an ice-pack on his head and everything.
  • Let's also not forget Ed's love of horror movies. In the Halloween special, Ed watches so many movies that during his trick-or-treat adventure with his friends, he hallucinates and sees the kids as many macabre figures, resulting in him giving them a beatdown. In other words, the whole special is basically a metaphor for one creepy drug trip.
• Family Guy:
  • In "Love Thy Trophy", Stewie gets addicted to a diner's pancakes so much that, when Child Services comes when hearing of Meg's lie about Stewie being her crack-addicted baby, his obsessive behavior only seems to confirm their suspicions. Finally, in The Stinger, he starts to go through a withdrawal process and begins hallucinating a la Trainspotting.
  • In "I Take Thee, Quagmire", Stewie became hopelessly addicted to his mother's breast milk. Lois tries to wean him, and he actually kicks the habit, but because of her engorged, painful breasts and missing the closeness breast-feeding offers, she soon hooks him again. Truth in Television; ask any nursing mother.
• The Frosty Freezy Freeze slushie from Fanboy and Chum Chum, a Trademark Favorite Drink of the eponymous duo. They can get a little obsessive over it and it becomes a major plot point in too many episodes to let it slip. Perhaps best evidenced by this sequence, from the episode "Berry Sick".
• Foster's Home for Imaginary Friends:
  • Mac gets hyperactive when he eats sugar. In the episode where Bloo throws a massive rave at Foster's, Mac unwillingly ingests sugar, then proceeds to go through a climbing-the-walls-nude drug trip from the effects. The post-rush withdrawal reduces him to a shivering wreck that's equal parts jonesing junkie and Gollum parody.
  • The episode "Cookie Dough" has Frankie devour thousands of boxes of her grandmother's cookies, which she has loved since she was a baby.
• Futurama:
  • The episode "Hell Is Other Robots" has Bender get addicted to electricity, which leads to the first appearance of the "Fry-fro", a funny hairstyle Fry gets on occasion. After an intervention, the main plot plays out when Bender decides to convert to a robot religion.
  • Lampshaded in a later episode when Bender tries electricity again and gets arrested for "possession of something analogous to drugs".
  • "The Butterjunk Effect" has this in the form of a nectar found on Kif's home planet, which acts like steroids, including the deepening of one's voice. Leela and Amy began to use nectar to win in Butterfly Derby matches, but it makes them meaner, especially towards Fry and Kif. It also makes them attracted to Fry after a vicious, giant butterfly sprays him with its butterjunk.
  • Futurama also features Slurm, whose tagline is "It's highly addictive!". Fry is shown to be extremely addicted to Slurm — even after he finds out what it's made of. When going more than twenty minutes without a Slurm, he starts to twitch and get shakes. It doesn't help that he's tasted the super-addictive Super-Slurm.
  • Apparently, there are no bad drugs in this setting. Hermes smokes pot (and doesn't lose it when his young son steals a "cigar" and smokes it). Crack is sold in vending machines, as well as crack mansions. Robots are fueled by alcohol. Bender becomes Iron Cook/Zinc Saucier by (unknowingly) dosing the meal with large amounts of LSD; once the Professor analyzes the liquid, Bender offers to cook a meal knowingly dosed, and everyone accepts eagerly. Interestingly, since Bender runs on alcohol, he gets drunk when he doesn't drink for a while!
• Galaxy High had an episode where Doyle becomes addicted to "Brainwaves" administered through a device called a "Brain Blaster", so that he could pass a test and retain his sports eligibility.
• In one U.S. Acres segment of Garfield and Friends, Roy asks Wade for "just one" of his peanuts. Despite Wade's warning that "nobody can eat just one" peanut, Roy insists. However, true to Wade's warning, Roy starts craving another, and when Orson's no-good brothers loot the peanut supply, Roy goes nuts trying to find more peanuts. (There's a bout of Hypocritical Humor at the end, where Orson, who's narrating, calls it dumb that anyone could go crazy over peanuts; then someone from offstage offers him a potato chip...)
• In the G.I. Joe: A Real American Hero episode "The Greatest Evil", Spark is a deadly drug peddled by Headman. Even Falcon and the sister of a Crimson Guard gets caught up in it. Thanks to the efforts of G.I. Joe's Drug Enforcement Force, Headman was finally confronted, and died from a taste of, or rather, a massive overdose of his own medicine.
• Gravity Falls:
  • "The Inconveniencing" has "Smile Dip", a banned German confectionery (and a parody of the real-life candy Fun Dip) that causes Mabel to hallucinate... although eating bleven-teen packages of it probably didn't help matters either.
  • In the short "Mabel's Guide to Color", Grenda reveals that drinking expired milk has this effect on her, since it makes her see rainbows.
• Tanning cream (oh, I'm sorry, crème) acts as this in one episode of Harvey Birdman, Attorney at Law, with Peanut even acting as dealer. Taken to hilarious extremes when Harvey's friends hold an intervention...all while indulging in more realistic vices, such as nicotine, alcohol, and gambling.
  Peanut: First taste is always free with P-to-the-N-U-T.
• In He-Man and the Masters of the Universe (1983), the episode "A Friend in Need" has Ileena become addicted to a blue potion given to her by a "sorceress" who uses her addiction to try getting her to steal the Transmutator. She starts to suffer a withdrawal and Prince Adam becomes concerned... but obviously not much, since he coldly dismisses her instantly when the weeping girl says she can't tell him what's wrong!
• Even Hey Arnold! had this, with chocolate. Regular chocolate. Chocolate Boy once went into a withdrawal, curling up into a ball and shivering when he didn't have it, as well as digging through dumpsters to find some.
• Kaeloo:
  • Quack Quack's yogurt. Without it, he undergoes withdrawal symptoms, and in one episode, everybody accuses him of cheating in an athletic event because he was eating yogurt.
  • A season 2 episode had Stumpy and Quack Quack get addicted to carrots, which produced the same effect as smoking tobacco.
• King of the Hill:
  • One episode has Bobby getting addicted to New York-style deli food, which ends up giving him Gout. When the chef making the food suggests that maybe he should stop eating, Bobby angrily screams out "I'll tell you when I've had enough!"
  • Another episode does this with charcoal, of all things; since Hank is practically a propane fanatic, his family decided to try charcoal grilling when he goes out of town. When he gets home and finds a loose briquette, we get a parody of traditional drug PSAs where he angrily interrogates Peggy and Bobby about it — Peggy even says "I thought it was drugs!".
• The Legend of Korra has Bolin get drunk on noodles.
• The Looney Tunes Show:
  • In "Off Duty Cop", Bugs Bunny gets addicted to Spargle, an energy drink he acquires from Yosemite Sam. He is extremely hyper, euphoric and over-productive when he consumes large amounts of it and freaks out when his supply runs out to the point of threatening Sam for more. Subverted when it turns out that Sparkle's secret ingredient is an unspecified but illegal and highly-addictive additive.
  • "Bobcats On Three!" has Bugs getting addicted to Porky's catering, after the latter switches to his grandmother's high in butter recipes. Bugs becomes obsessed with getting his hands on more of Porky's cooking and wastes a lot of money hosting parties with random strangers pulled off the streets. Even the other characters try to warn Bugs eating too much of that stuff isn't healthy, pointing out he's steadily growing fatter until he gets humongous and Porky cuts him off. Bugs manages to kick the habit after he empties an entire swimming pool jumping to save Daffy from drowning.
• In Mega Man (Ruby-Spears), the meteor fragments in Red Gulch (as seen in "Showdown at Red Gulch") were this to robots.
  Mega Man: I felt great at first! But then I got really weak.
• Menin Black The Series: Coffee is this for the worms. Their obsession with the beverage has made them do a lot of foolish things throughout the series, including draining cooling water from a nuclear reactor just to make a pot.
• My Little Pony: Friendship Is Magic:
  • The episode "Hearts and Hooves Day" has the love poison. After Big Macintosh and Cheerilee drink some, they become obsessed with one another and call each other increasingly sickening pet names. Doesn't help that the Cutie Mark Crusaders serve it to them in shot glasses and it makes them both hiccup after they drink it.
  • In "Inspiration Manifestation", the spellbook effectively serves as this for Rarity. Under its influence, she stops eating, grows increasingly manic in her behavior, and is only free of it when Spike finally stops enabling her and makes her realize how harmful it is.
• Pepper Ann once had the title character getting obsessed with Baggy Bean Buddies, getting dirty and disheveled while selling her things for money to buy them. Turns out she's not the only one, as there's a help group for fellow addicts.
• Popeye. Come on, you honestly never thought of the spinach = steroids connection? One Popeye cartoon has Bluto replacing Popeye's spinach with locoweed.
• The Powerpuff Girls (1998): There are a couple of examples, both played surprisingly somber and serious for the show, in that the substances themselves might be goofy or fantastical, but the consequences are appropriately dire.
  • In one episode, Mojo Jojo offers four diverse kids from the Girls' class temporary superpowers from a Chemical X knockoff. Before long, they are willing to kill the Powerpuff Girls for the next fix.
  • In the episode "Candy is Dandy", the mayor starts rewarding the girls with candy for their heroics. Not only is the effect disturbingly similar to a drug high, but the Girls are also willing to abandon their morals to get more: first they strike a deal with Mojo Jojo and repeatedly break him out of prison so that they could arrest him and get candy. When Mojo reneges on the deal and steals the candy instead For the Evulz, the Girls literally beat him to within an inch of his life. This is the point the girls realize how badly their addiction has affected them.
• Regular Show:
  • In this world, soda acts like beer, donuts may be dangerous, and coffee...
  • In the episode "Weekend at Benson's", the main characters drink a concoction of seafood, mayonnaise, and various spicy things called "Mississippi Queen". After hallucinating vividly, they wake up in the park, hung over and unable to remember what happened.
  • In Gold Watch, after eating hot wings Benson is told by Skips "a lot of people do things they regret on a belly full of wings" and he was told to take it easy on them. He wakes up not remembering anything after having too many.
• Rocko's Modern Life:
  • In "Sugar Frosted Frights", Filburt has his first taste of Halloween candy and transforms into a complete psychopath, breaking into homes just to eat as much sugar as possible.
  • In "Flu-In-U-Enza", Rocko takes a suppository for his flu orally, causing his eyes to swirl and make everything around him swerve wildly, making him dizzy and causing him to throw up.
• Rugrats
  • An earlier episode, "Weaning Tommy", has Tommy give up drinking from a bottle, which could also be a metaphor for giving up alcoholism.
  • Similarly, the episode "No More Cookies" is basically a g-rated version of drug addiction, in which Tommy and his friends try to keep Angelica from eating any more cookies after her addiction gives her a massive stomachache. Heck once you learn the definition of the term "pot cookies", you probably wouldn't look at this episode the same way again.
• Parodied in the Sealab 2021 episode "Chalkboard Jungle". Debbie Love explicitly states that, as per written instructions from Standards and Practices and Production Council offices, she is enjoying her hookah in a drug free way. She then immediately giggles after smoking it.
• The Simpsons:
  • In "Brother's Little Helper", Bart gets addicted to Focusyn, which seems to be a stand-in for Ritalin until the end of the episode where Marge says she's getting Bart off of Focusyn... and back on Ritalin.
  • In "Round Springfield", Bleedin' Gums Murphy recalls squandering money on his "$1500 a day habit." Cut to a flashback of him buying Faberge Eggs.
  • In "Boy Scoutz 'N The Hood", Bart and Milhouse go on a bender after drinking a Squishee "made entirely of syrup", which leads to Bart joining the local scout troop and Milhouse getting a rude word shaved into the back of his head.
  • In "Love, Springfieldian Style", Lisa as Nancy Spuggen and Nelson as Sid Vicious get hooked on chocolate as if it were cocaine or heroine. Their chocolate spree involves them snorting lines, cooking (melting chocolate powder on spoons), and flushing chocolate bars and candy down the toilet when the cops come a-knocking.
  • "The Mysterious Voyage of Homer" had the Guatemalan insanity peppers, which gave Homer an experience akin to a peyote trip. This actually is Truth in Television, as sufficiently spicy foods can really cause hallucinations.
  • The Ribwich from "I'm Spelling as Fast as I Can" is so unhealthy that there is a scene (a Shout-Out to Requiem for a Dream) where we see barbecue sauce flowing in Homer's bloodstream and thus he develops a huge addiction to the product.
  • In "The Bart of War", when Bart and Milhouse find Ned Flanders' Beatles memorabilia room, they decide to try some nearly 40-year-old Beatles sodas ("John Lemon", "Orange Harrison", "Paul McIced Tea", and "Mango Starr"). Bart tries the "John Lemon" soda and imagines Milhouse as John Lennon throughout his life, from Beatlemania to "Sgt. Pepper" to "Let It Be" to "Double Fantasy".
  Bart: Oh, yellow matter custard, dripping from a dead dog's eye...
• The Smoggies has purple silly sauce, a G-Rated Drug powerful enough to contaminate an ecosystem and cause whomever comes into contact with it to involuntarily sing and dance perpetually, even in diluted amounts. The song they sing, "The Purple Rag", is an Ear Worm as well as being a state of And I Must Scream.
• South Park has had episodes based around people getting high on DXM^note that means cough syrup; you can get high off it. If you buy it mixed with DPH, you'll get some really nasty hallucinations; if you buy it mixed with other chemicals such as acetaminophen, and ingest enough to get high, the additional chemicals can kill you ("Quest for Ratings") and cat urine ("Major Boobage"), and in another episode, Cartman snorts the skin off of illegally-obtained KFC ("Medicinal Fried Chicken"). "Medicinal Fried Chicken" additionally has a subplot of many of the male adults deliberately getting testicular cancer so they can smoke all the medical marijuana they want.
• Space Goofs has Gorgious hopelessly addicted to sugar, secretly stashing candy everywhere in the house and acting like a coke fiend in withdrawal when it is taken away.
• Since Harry Osborn's amphetamine addiction was too touchy a subject to use in a cartoon aimed at children, The Spectacular Spider-Man compensated by having him instead develop an addiction to "Globulin Green," the serum that turns him into the Green Goblin.
• In SpongeBob SquarePants, Krabby Patties can be considered as these. For starters, they are very fattening, and eating many of them will give anyone a heart attack, or they go right to their thighs and literally explode. Inversely, if someone doesn't get a Krabby Patty for a great amount of time, not only will they suffer withdrawal, but they tear the entire city apart, to the point of creating an apocalyptic setting. In the episode "Cuddle E. Hugs", SpongeBob eats a moldy Krabby Patty and meets a fluffy, smiley, and Disney-esque hamster, but he is initially the only one who is able to see him. In an attempt to prove that he is real, they give all of SpongeBob's friends (except Squidward) pieces of said Krabby Patty. Cuddle E. Hugs then proceeds to eat everyone who can see him.
• An episode of Static Shock features a Bang Baby with the ability to give other people superpowers temporarily... at the price of not telling anyone where they got them; oh, and they have to steal stuff for him. Well, if you want to get high — uh, get superpowers...
• SWAT Kats sees not only catnip used as drugs, but milk as synonymous with alcohol.
• In Teen Titans (2003), Cyborg becomes addicted to the power that a new processor has given him, allowing him to do more things in a day than possible. However, when faced with the multiplying enemy named Billy Numerous, Cyborg ends up draining his internal systems and using the Titan Tower's own power supply to keep his processor functioning, which ultimately leads to a system crash that forced his teammates to remove the new processor.
• Tiny Toon Adventures used alcohol, yet with amusingly sarcastic bookend scenes; Buster points out the obvious hyperbole in them doing a Very Special Episode and closes by optimistically assuming they'll get to do a "funny" episode again.
• In Total Drama's first season, the underage Courtney recklessly wolfs down sandwiches at the boot camp party in a child-friendly metaphor for binge drinking. Despite Bridgette's admonition that "I think you've had enough", Courtney eats one too many and shortly thereafter pukes over the porch railing.
• In the Totally Spies! episode "Passion Patties", the villain of the week works for a cookie company and adds a chemical to their new Passion Patties cookies that makes them not only incredibly addictive, but also causes the consumer to gain absurd amounts of weight in a very short time. Naturally, one of the girls (Clover) becomes hooked on them during the episode.
• In Transformers: Animated, motor oil is treated like beer/alcohol, with Those Two Guys Mixmaster and Scrapper being especially fond of it.
• In Transformers: Prime, Ratchet creates Synthetic Energon and then injects himself with it, causing him to gain immense strength, but renders his mind unstable, making him aggressive and incredibly arrogant.
• In the Wander over Yonder episode "The Fremergency Fronfract", Lord Hater spends most of the episode loopy from the anesthetic his dentist used... which, in this case, is some kind of electric squid that shocks Lord Hater's face.
• Winx Club: Not straight in the series but in the official comics of the franchise, specifically in issue#52: Infernal Concoction where the Trix sisters brew a dangerous potion, Mistura Infernalis, from an ancient-looking book from Cloud Tower's library and melt it in the form of red candies. It enhances human potential by boosting energy and improving mood as well as other mental and physical capacities such as memory. They sell them by the name of Sublimax to their classmates and get rich while using them as Guinea Pigs to explore the drug's side effects. Non-so-surprisingly, it turns out as harmful as a real-life drug: extreme exhaustion, dependence, and withdrawal.
• WordGirl: Dr. Two-Brains has a mouse brain attached to his human one, which gives him an immense craving for cheese. He's nuts for cheese, even turning to a life of crime to get his hands on more of it - which what makes him WordGirl's nemesis.
• Young Justice (2010)
  • The first time we see Red Arrow after the five year Time Skip, he's now sporting an emaciated, disheveled appearance and seems exhausted and unable to concentrate. While never stated onscreen, it's hard not to read the situation as a callback to his heroin addiction from the comics. Especially since his friends essentially give him an intervention to snap him out of his self-destructive behavior.
  • Superboy's addiction to "Shields" (patches developed by Lex Luthor that give him access to Kryptonian-level abilities) is also treated like a metaphor for drug abuse. The whole subplot comes off like a cautionary tale about the dangers of steroids.

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