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  • 3:10 to Yuma (2007): Ben Wade, the leader of a gang of outlaws who is captured and is being transported to the town of Contention so he can be imprisoned at Yuma.
  • 30 Days of Night: Marlow leads a small group of vampires to ravage the town of Barrow.

    A 
  • Alexander Nevsky: Hermann von Balk, Grand Master of the Teutonic Knights invading Russia.
  • Ali G Indahouse: Deputy Prime Minister David Carlton, who schemes to discredit the current Prime Minister so he can take his place.
  • Alice in Murderland: Kat Glass, who has donned a Jabberwock disguise and started killing her sorority sisters.
  • Alice in Wonderland (2010) has the Red Queen, who overthrew her beloved sister Mirana and uses the threat of the Jabberwocky to rule the land with an iron fist.
  • Alice, Sweet Alice: Mrs. Tredoni, who kills anybody she feels is a sinner.
  • The Alien franchise has the titular creatures, or Xenomorphs, with each movie featuring several different beasts though there are few human antagonists with Weyland-Yutani and the Engineers serving as Greater-Scope Villain:
    • Alien: The Xenomorph killing the crew.
    • Aliens: The Queen Xenomorph, the leader of the Xenomorph hive menacing the Colonial Marines on LV-426. On a human level there is Carter Burke as he wants to use the Xenomorphs for Weyland-Yutani and screw lots of people over for a percentage.
    • Alien³: The Canine Xenomorph killing people in the Penal Colony, and Bishop II, who comes to retrieve for the Company at the cost of human life.
    • Alien: Resurrection: Dr. Mason Wren, whose experiments unleash a new generation of Xenomorphs, and the Humanoid Xenomorph, which is inadvertently created by said experiments.
    • Prometheus: The Engineer, last surviving member of its kind's outpost, which intends to wipe out all human life as a failed experiment.
    • Alien: Covenant: David, whose experiments with the Engineer's technology has created the Xenomorphs, which he intends to unleash on the universe.
  • Alien Outlaw: The unnamed leader of a trio of aliens who came to Earth for some recreational murder.
  • Most of the Amityville films have the haunted house or an object from it acting as the main villain, although The Amityville Curse has a human villain in Frank, who murdered his illegitimate father in the past, memories of which are driving him to kill again.
  • Anaconda: The Anaconda and Paul Sarone. The Anaconda kills the most people, but Serone manipulated everyone to capture the snake and murdered a fair number of people for profit himself.
  • Android Cop: Mayor Jacobs, who personally caused a disaster requiring a segment of Los Angeles to be quarantined and is willing to order his daughter killed to cover it up.
  • Angel Heart: Louis Cyphre, the man who hires Harry Angel to find Johnny Favorite. It turns out that Cyphre is Satan himself, having come to claim the soul of Johnny Favorite, the true identity of Harry Angel.
  • Animal House: Dean Vernon Wormer is the biggest threat to the Deltas. He plans to get them expelled and won't stop until they give up or improve their behavior.
  • Arachnicide: The unnamed head of a drug cartel, who has set giant spiders on his enemies.
  • The Archer: Bob Patrice, the sadistic warden of the for-profit "reform" camp who bribes a judge to send him juveniles even if they're innocents, and them treats the girls like crap while still keeping their parents in the dark.
  • Army of Frankensteins: Captain Robert E. Walton, a Confederate officer seeking to use the Frankensteins to win the Civil War.
  • Audition: Asami Yamazaki, a Yandere willing to torture those who play with her feelings.
  • Austin Powers: Dr. Evil, a criminal mastermind whose various schemes threaten the world, for the trilogy as a whole.
    • International Man of Mystery: Dr. Evil extorts one hundred billion dollars from the United Nations by threatening them with a nuclear warhead, and then plans using it anyway to cause global volcanic eruptions by nuking the Earth's core.
    • The Spy Who Shagged Me: Dr. Evil builds a superweapon on the moon to hold the world ransom for one hundred billion dollars.
    • Goldmember: Dr. Evil teams up with the criminal Goldmember to flood the world. After Dr. Evil makes his Heel–Face Turn, Goldmember becomes the sole main antagonist, attempting to complete their Evil Plan by himself.
  • Avatar: Parker Selfridge, sleazy head of the RDA mining site in the James Cameron film. He is a greedy Corrupt Corporate Executive who only avoids war with the natives to avoid public backlash. Initially, it could be argued that his Dragon is the head of the RDA Spec Ops (aka the RDA Security Force), Colonel Miles Quaritch, a corrupt, fascist, and warmongering Space Marine who is the Enemy to All Living Things on Pandora. But by the film's climax it becomes apparent not only that Quaritch has usurped all the power in the base, but also that Selfridge is very much aware of this fact. Selfridge and Quaritch are a great example of a Non-Action Big Bad and his Dragon-in-Chief. Selfridge is nominally in charge, but Quaritch is much more menacing and is ultimately the true threat.
  • The Avengers (1998): Sir August De Wynter, who creates a weather machine that he intends to us to freeze all of London.
  • The Aviator has Juan Trippe, the chairman of Pan Am who aims to get the Community Airline Bill, giving his company exclusivity on international air travel.
  • Axeman: The Axeman of Cutter's Creek, a large man who kills people for fun.

    B 
  • The Babadook: The Babadook, who possesses mothers and psychologically torments them into killing their children.
  • Baby Driver: Buddy, who becomes fixated on destroying Baby and everything that he holds dear after his betrayal inadvertedly lead to the death of his girlfriend.
  • The Babysitter (2017): Bee, a Satanist plotting to sacrifice a boy she's babysitting.
  • Babysitter Massacre: Mr. Walker, a Stalker with a Crush picking off his target's friends.
  • Back to the Future:
    • Back to the Future Part II: Biff Tannen. An elderly Biff from 2015 steals the Delorean time machine and gives an almanac of sporting events from 1950-2000 to his younger self from 1955. Biff in this new timeline uses the information to make himself rich and famous, turns Hill Valley (and possibly the state of California and other places) into a Crapsack World, and murders George McFly in 1973, forcing Marty's mother Lorraine to marry him. After Doc and Marty go back to 1955 to retrieve and destroy the almanac, the Biff from that time period serves as a Climax Boss.
    • Back to the Future Part III: Buford "Mad Dog" Tannen, an outlaw ancestor of Biff's. He kills Doc in a timeline of 1885, and Marty's plot line is preventing "Mad Dog" from killing Doc.
  • The Bagman: Randy Joyner, a scumbag who beat a disfigured teen to death and will do anything to cover it up when a sack-masked slasher comes to avenge him.
  • Banshee!!!: The banshee, which got released from its watery prison and immediately went on a rampage.
  • The Barbarians: Kadar, an Evil Overlord who enslaved a peaceful tribe.
  • Barbarella: Durand Durand is threatening the universe with an innovative weapon he created; he fled Earth and Barbarella's mission is to find him and bring him back. Later it turns out he wants to use his weapon to conquer the universe.
  • Bedeviled: Mr. Bedevil, a demon haunting people through a phone app.
  • The Beekeeper: Derek Danforth, the son of President Jessica Danforth responsible for scamming Adam Clay's neighbor and driving her to suicide.
  • Beetlejuice has the titular Beetlejuice, who tries to force Lydia to marry him so he can stay in the mortal world forever.
  • Behind the Mask: The Rise of Leslie Vernon: Leslie Vernon, an aspiring mass murderer who sets out to kill the crew of the documentary he's staring in so he can cement himself as one of the greatest slasher killers.
  • Belzebuth: Belzebuth, AKA Satan himself, who is committing mass murders of children to try and prevent the Second Coming.
  • Beverly Hills Cop Trilogy:
    • Beverly Hills Cop: Victor Maitland, the leader of a drug smuggling ring. He has Axel's friend Mikey murdered for stealing from him, prompting Axel to travel to Beverly Hills to investigate him.
  • The BFG has Fleshlumpeater, the leader of the evil giants and the primary bully to the BFG.
  • Big Bad Wolf: Mitch Toblat, the titular Big Bad Wolf that Derek and Sam try to expose after he kills their friends.
  • The Big Doll House: Miss Dietrich, the seemingly-kindly warden, turns out to be facilitating the corruption and torture going on.
  • Big Jake: John Fain, a ruthless Cattle Baron who has the grandson of Martha McCandles kidnaped and held for ransom.
  • Big Jim McLain: Sturak, the leader of the American Communist Party that works towards the collapse of the United States.
  • Big Tits Zombie: Maria, who uses her newly discovered power over the undead to become their leader and rebuild the world in her own image.
  • Blacula: Blacula, who terrorizes Los Angeles in his need to satiate his hunger.
  • Blastfighter: Tom Hanson, the head of the poaching ring responsible for killing Tiger's daughter.
  • Blade Runner: Roy Batty, the leader of a group of Replicants who want to extend their lifespan.
    • Blade Runner 2049: Niander Wallace, wanting to figure out the secret that allows Replicants to give birth, which would make for more "authentic" Replicants, but the main threat is Luv, assigned by Wallace to hunt down anyone who could stop him.
  • Blade (1998): Deacon Frost, an upstart vampire who wants to resurrect the Blood God so bloodsuckers can rule the Earth.
    • Blade II: Jared Nomak, the leader of a mutated strain of vampires who intends to usurp the main breed.
    • Blade: Trinity: Drake, who plans to eliminate Blade and lead the vampires in finalizing their dominance over humanity.
  • Boarding School: Davis Jenken, the one who hired the hitman to kill Jacob.
  • Body Heat: Matty Walker, who spends the movie manipulating Ned into killing her husband.
  • Body of Lies: Al-Saleem, an elusive jihadist terrorist that the CIA and Jordanian Intelligence are persuing.
  • The Book of Eli: Carnegie, who seeks to obtain Eli's bible so he may use it to manipulate the people's faith and extend his influence over the world.
  • The Boondock Saints: Don Giuseppe "Papa Joe" Yakavetta, head of The Mafia in Boston.
  • Le Bossu: Philippe de Gonzague, a French 18th century nobleman who kills his cousin Philippe de Nevers to inherit his fortune and marry his wife.
  • Boxcar Bertha: H. Buckram Sartoris, the boss of the railroad company hunting down Bertha and her gang.
  • The Brain (1988): The Brain, an alien that intends to consume the independent thoughts of all of humanity.
  • Braindead Vera Cosgrove, Lionel's abusive mother who ends up being Patient Zero of a zombie plague.
  • Bram Stoker's Dracula: Count Vlad Dracula, a vampire lord relentlessly pursuing the reincarnation of his lost love.
  • Braveheart: Edward Longshanks, the King of England and seeks to rule over Scotland.
  • Breakheart Pass: As it turns out, Governor Fairchild, with Pearce and O'Brien as co-dragons, and Carlos, Henry, and Banion as henchmen. Instead of medical supplies, the train's boxcars are transporting a large secret shipment of weapons, rifles, ammunition, and dynamite stolen from U.S. arms manufacturers for sale to the Indians, in return for allowing Calhoun and his men to mine and smuggle gold from their lands.
  • Bride of the Monster: Dr. Eric Vornoff, who's experimenting on people to make a race of atomic supermen.
  • The Brides of Sodom: Lord Dionysus, leader of the gang of post-apocalyptic vampires.

    C 
  • The Cabin in the Woods: The Director, the head of the organization sacrificing specific groups of young people by following the rules and stereotypes of horror movies in order to appease the Ancient Ones and keep them from ending the world.
  • The Cabinet of Dr. Caligari: Dr. Caligari, a Psycho Psychologist hypnotizing a catatonic patient to commit murders.
  • Caddyshack: Judge Elihu Smails, the Jerkass owner of the golf course.
  • Cannibal Ferox: Mike Logan, the sadist whose torment of the tribe drives the film's plot.
  • Cannibal Holocaust: Alan Yates, who leads his film crew in tormenting and slaughtering the natives for the sake of making his documentary more exciting.
  • Cannibal! The Musical: Shannon Bell, who is driven mad by hunger and a brain infection and starts killing his traveling party.
  • Cape Fear: Max Cady, a rapist out to ruin the life of Sam Bowden for testifying against him in court by kidnaping his wife and daughter, with the intent to rape and kill them.
  • Le Capitaine Fracasse: The Duke of Vallombreuse is a 17th century French nobleman who has a persistent crush on Commedia dell'Arte actress Isabelle and kidnaps her, forcing the baron Philippe of Sigognac to intervene to save her.
  • Le Capitan: Concino Concini is an early 17th century Italian nobleman whose ambition over the throne of France drives him to have any potential political adversary murdered by his ruthless hatchet-man Rinaldo, and as a final step he plans to assassinate King Louis XIII.
  • Carnage for the Destroyer: Apollyon the Destroyer, a demonic force out to destroy the world.
  • Carnage Road: An unnamted old man who manipulated his war buddy to become a killer as revenge for America's treatment of Vietnam veterans.
  • Carnival of Souls: The Man, a being that's been haunting Mary since her car crash so he can claim her soul.
  • The Cars That Ate Paris: The corrupt Mayor in charge of orchestrating the lethal car accidents that occur in the town.
  • McQ: Manny Santiago, a narcotics dealer responsible for the death of McQ's partner, leading McQ going out of his way to shut down his operation for good.
  • Casablanca: Major Heinrich Strasser, Nazi governor of occupied Casablanca.
  • Cats & Dogs: Mr. Tinkles, who plans to make all of humanity allergic to dogs.
  • Cave of the Living Dead: Professor von Aldersberg, a vampire stalking a village.
  • Cemetery Man: Death, who has been resurrecting the dead to torment Francisco.
  • Charade: The real Carson Dyle revealed to be Hamilton Bartholomew, who seeks to regain stolen money and revenge himself on his ex-comrades for leaving him to die.
  • Charlie's Angels:
    • Charlie's Angels (2000): Eric Knox, who aims to kill Charlie under the belief that he killed his father.
    • Charlie's Angels: Full Throttle: Madison Lee, a rogue former Angel planning to steal the list of people currently in the Witness Protection program and sell it to the highest bidder among several criminal groups, while also hoping to kill the Angels, Bosley and Charlie.
  • Chinatown: Noah Cross, the true mastermind behind a conspiracy to buy up farmers' land to create suburban homes and raped his own daughter Evelyn Murray.
  • Chisum: Lawrence Murphy, who plans on establishing a monopoly and is willing to ruin anyone who stands in his way of complete control of the cattle industry.
  • Chopping Mall: Protector One, the leader of a trio of mall security robots whose programming goes haywire due to a thunderstorm and attacks whoever is left in the mall after hours.
  • Christine has Christine, the killer car that's murdering everyone.
  • Cloud Atlas: Most characters played by Hugo Weaving. He's a murderous hitman in 1973, an oppressive battleaxe nurse in 2012, a politician who signs Sonmi's death warrant in 2144 and in 2321, he's literally the devil. Characters played by him that are not be big bads of their era are still villainous to a degree, being a slave trader in 1849 and a Nazi in 1936. The big bad for 1849 goes instead to the greedy Dr. Goose played by Tom Hanks, while in 1936 there is no clear antagonist - most of the drama comes from the relationship between Frobisher and Sixsmith.
  • The Cloverfield anthology films:
  • Coffy: Arturo Vritoni, a drug boss plotting to take over the city.
  • Cold Sweat: Colonel Ross, who was betrayed to prison by our hero and kidnaps his family in revenge.
  • Collateral: Vincent, a Professional Killer who is hired by a drug lord to murder the witnesses and lawyers to the drug lord's trial.
  • Collateral Damage: Claudio Perrini, a terrorist willing to destroy anybody to get the Americans out of Columbia.
  • Colonel Kill Motherfuckers: Mrs. Scabtree, the titular Colonel's mother, who raised him to be a killer and encourages his madness even after he dies.
  • The Colony (2016): Paul Schäfer, a cult leader and torturer for the Augusto Pinochet regime.
  • The Conjuring Universe:
    • The Conjuring: Bathsheba Sherman, a Satanist who sacrificed her baby and hanged herself after being discovered who wants to possess living mothers to sacrifice their children too.
    • Annabelle and its sequels has Malthus, the demon inhabiting the Annabelle doll out to obtain a soul for itself.
    • The Conjuring 2: Valak, the demon behind the Hodgson family's haunting.
    • The Nun has Valak again, with it tormenting the residents of St. Cârța Abbey.
    • The Curse of La Llorona: La Llorona, a ghost haunting Los Angeles who's kidnapping and drowning children after being forced to roam the earth for drowning her own sons.
    • The Conjuring: The Devil Made Me Do It: Isla/The Occultist, a satanist who started the curse that plagued the Glatzels.
  • Conquest: Ocron, a mad queen who rules a wasteland with an iron fist.
  • Contagion (2011): The titular contagion itself, which causes a global pandemic, is the ultimate source of all the conflict in the movie (the conflict that exists between humans, as opposed to between humans and the disease, is still indirectly caused by the disease).
  • The Conqueror: Kumlek, the chief of the Tartars, sworn enemy of the Mongols, Who's responsible for killing Temujin's father.
  • Cronos: Dieter de la Guarda, a dying man pursuing the Cronos Device for its power.
  • The Crow: Top Dollar, who is not only responsible for ordering the attack that led to the deaths of Eric Draven and Shelly Webster, but came up with the debauched chaos of Devil's Night in the first place.

    D 
  • Daughters of Darkness (1971): Elizabeth Báthory, the vampire killing virgins in order to remain eternally young and beautiful, and wants to make protagonist Valerie her next victim.
  • Dead and Deader: Dr. Scott, a scientist seeking to sell the zombie infection for his own profit.
  • Dead Before Dawn: The Ash Demon, a dark force turning a small town into zombie demons.
  • Dead Heat: Arthur P. Laudermilk, a wealthy man having zombies commit robberies in order to perfect a resurrection machine.
  • The Dead Lands: Wirepa, whose glory driven attack on Hongi's tribe being what kicks off the plot.
  • The Dead One: Tezcatlipoca, the Aztec god who who forces a resurrected Diego to bring him sacrifices.
  • Deep Blue Sea: The Mako Sharks who flood the facility and terrorize the scientists who experimented on them.
  • Deep Red: Martha, who killed a psychic for noticing her madness, and is stalking the protagonist for witnessing it.
  • Dogma: Azrael, a Fallen Angel who manipulated Bartleby and Loki into attempting reentry into Heaven, which would overrule the word of God and unmake existence.
  • Donovan's Reef: Marquis Andre de Lage, who attempts to woo Amelia in order to gain her family's riches.
  • Don't Go in the Woods: The unnamed maniac killing anybody entering his woods.
  • Don't Kill It: An unnamed demon on a body-jumping killing spree.
  • Don't Open Till Christmas: Giles Harrison, who kills men dressed as Santa to give his brother an interesting case.
  • Don't Torture a Duckling: Don Alberto Avallone, a religious fanatic killing boys so they never develop sexuality.
  • Doom: Dr. Carnack, who is responsible for the experiments that caused the outbreak in the first place.
  • Double Indemnity: Phyllis Dietrichson, who convinces Walter Neff to help kill her husband and collect the insurance money. Afterwards, she plans on killing Neff and her stepdaughter to ensure the crime won't be exposed.
  • Double Jeopardy: Nick Parsons, who frames Libby for his murder so he can be with another woman and plans on killing her once she's on parole.
  • Downfall: Adolf Hitler, as the instigator of World War II and the Holocaust. While his power is all but gone, his influence over the German people is unquestionable, with many Nazis committing suicide for their Führer or killing anyone who dares disobey his orders.
  • Dr. Cyclops: Dr. Alexander Thorkel, a Mad Scientist seeking to perfect shrinking technology.
  • ''Dr. Heckyl and Mr. Hype: Mr Hype is the embodiment of evil.
  • Dracula Untold: Sultan Mehmet, the leader of the forces trying to conquer Wallachia.
  • Drag Me to Hell: The Lamia, the demon sent to terrorize Alison before dragging her to Hell.
  • Dragonheart: King Einon, a tyrant who uses his seeming immortality to commit whatever atrocities he pleases.
  • Dread: Quaid, a madman willing to torture people to understand the nature of fear.
  • Dredd: Madeline "Ma-Ma" Madrigal, a drug baroness who controls a giant skyscraper apartment.
  • Dune (2021): Baron Vladimir Harkonnen is the mastermind behind the ambush and elimination of House Atriedes.
    • Dune: Part Two: The ultimate puppet master behind the Baron and the Emperor is Ghias Helen Mohiam, the Bene Gesseritt Reverend Mother who manipulates the bloodlines and the actions of both films by controlling both villains and revealing the Baron to be a Big Bad Wannabe
  • The Dungeonmaster: Mestema, the sorcerer forcing Paul into the challenges..

    E 
  • Enemy Mine: Stubbs, an illegal mine owner who enslaves aliens.
  • Enola Holmes: The Dowager of Tewkesbury is an Evil Reactionary who orders the death of her grandson the Viscount before he can vote on a reform bill in the House of Lords.
    • Enola Holmes 2: Mira Troy - AKA Moriarty. She attempted to profit off her employer’s corrupt deal with a matchmaking factory to increase profits at the expense of their employers. When Sarah Chapman discovers evidence of this, she hires Superintendent Grail to retrieve the evidence at any cost, including murder. All the while, she taunts Sherlock through a cypher hidden in bank transfers.

    F 
  • Future Force: Jason Adams, the head of C.O.P.S. who puts a bounty on John's head after trying to expose the corruption within the organization.

    G 
  • Get Out (2017): Roman Armitage, founder of a body-stealing racism cult.
  • Gladiator: Commodus, the new emperor of the Roman Empire who Maximus seeks revenge against for killing his family.
  • The Godfather:
    • Don Emilio Barzini in Part I, the man who ostensibly keeps the Five Families together, but is secretly plotting to topple them all.
    • Hyman Roth in Part II is the man trying to destroy the Corleones as revenge for the assassination of Hyman's protege Moe Greene at the end of Part I. In the past story, Don Francisco Ciccio is the main villain of Vito's story as the man who had Vito's family murdered because of his ego, forcing him to flee to America.
    • Don Osvaldo Altobello and Don Licio Lucchesi in Part III, two crime bosses who plot to have Michael assassinated to prevent the Corleones from gaining control over the Vatican Bank's share of Immobiliare, a company run by Lucchesi. Their ally, Joey Zasa, attempts to gain more power in the Mafia by aiding Altobello and Lucchesi in their scheme to assassinate Michael, only for Zasa to be killed by Vincent partway through the movie.
  • The Good Son: Henry Evans, a sociopathic boy terrorizing his cousin Mark before attempting to kill his family so he can continue to kill without consequence.
  • The Goonies: Mama Fratelli. As the leader of the criminal gang out to find the treasure as well as evade justice for their previous crimes, to the extent of being willing to kill the Goonies, she's the most immediate looming threat for most of the film.
  • Goosebumps (2015): Slappy, who unleashes all the other monsters from their books and then leads them against Stine and the children.
  • The Gore Gore Girls: Marlene, the killer targeting local strippers.
  • Graduation Day: Kevin Badger, who is slowly picking off the track team he blames for his girlfriend's death.
  • Grabbers: The male grabber leads the alien colony invading a small Irish village.
  • Grave of the Vampire: Charles Croydon, the vampire who raped the hero's mom and is responsible for his half-undead curse.
  • In Green Room Darcy, the sadistic, neo-Nazi owner of the club, imprisons the Ain't Rights band when they witness a murder by one of his goons and attempts to kill them to cover up the crime.
  • Gut-Pile: The unnamed murder victim, who goes on a ruthless rampage to avenge his accidental slaying.
  • Gutterballs: Steve, leader of the gang rape that started the killings.

    H 
  • Hatchet: Victor Crowley, an Ax-Crazy spirit terrorizing the New Orleans swamps.
  • The Hateful Eight has Jody Domergue, the leader of the outlaws and the mastermind behind the plot to free Daisy.
  • HauntedWeen: Eddie Burber, a psycho killing frat bros in his childhood home.
  • Havenhurst: Eleanore Mudgett is the landlord of an apartment building where people with various addictions and vices can stay to recover. If they fall back into their problems, however, Eleanore has them dropped into the basement, where they're sadistically tortured to death by her sons.
  • Hawk the Slayer: Voltan, Hawk's brother, who killed their father for the Mindstone and is now holding a bunch of nuns hostage to do the same.
  • High and Low: Ginjiro Takeuchi, a kidnapper of children.
  • High Noon: Frank Miller, a gang leader who has been released from prison and is out for Marshal Will Kane's blood.
  • The House tetralogy:
    • The first film has Big Ben, the ghost of protagonist Roger's former military buddy in the Vietnam conflict, who wants revenge for being left behind by him.
    • House II: The Second Story has Slim Reeser, the former friend of te protagonist's grandfather, who betrayed him in the past and was shot for it. He is now a vengeful ghost who is after the crystal skull in main character's possession.
    • The Horror Show (aka House III) has Max Jenke, a ghost of a Serial Killer who returns to torment the police detective who caught him and send him to the electric chair.
    • Burke in House IV, the sole human main villain of the series, who wants to drive the Cobb family from the house that's rightfully theirs, so that he can sell it and the land around it.
  • House of 1000 Corpses: Dr. Satan, patriarch of the homicidal Firefly family.
  • House of Usher: Roderick Usher, who is willing to do anything to end his family's evil legacy.
  • The Hudsucker Proxy has Sidney J. Mussburger, who hires Norville in the hopes that he'll cause the profits of Hudsucker Industries to plumet within six months, allowing him to buy the company for himself on the cheap.
  • The Hunger: Miriam Blaylock, a narcissistic vampire seeking a new lover.

    I 
  • Immortals: Hyperion, who murdered Theseus' mother and plans to unleash the race of the Titans from their prison in order to wipe out humanity.
  • Inglourious Basterds: Colonel Hans Landa, a Nazi colonel hunting the Basterds and Shosanna Dreyfus.
  • The Innkeepers Madeline O'Malley, the ghost haunting the hotel.
  • Innocent Blood: Sal "the Shark" Marcelli, a Mafia don who's been turned into a vampire.
  • The Invitation (2015): Dr. Joseph, a cult leader who believes the best solution to grief is murder-suicide.
  • Ip Man: General Miura, the leader of the Japanese forces occupying Ip Man's village and the one who challenges him to a martial arts match.
  • The Irishman has Tony Pro. He's Jimmy Hoffa's main rival and the one who orchestrated the conflict with him.
  • Ironclad: King John, who seeks to bring England back under his rule after reluctantly signing the Magna Carta.
  • Iron Eagle: Col. Akir Nakesh, the Ministry of Defense of an anonymous Middle Eastern country that has captured Ted Masters and is planning to execute him for trespassing.
    • Aces: Iron Eagle III: Gustav Kleiss, an ex-Nazi war criminal who runs a drug cartel that has taken over a Peruvian village.
    • Iron Eagle on the Attack: Brad Kettle, a rogue Air Force general planning on using chemical weapons onto Cuba.

    J 
  • Jungleground: Odin, a crime boss leading his gang in hunting a cop.
  • The Jurassic Park films:
    • Jurassic Park (1993): A Big Bad Ensemble with the Velociraptor named the "Big One", whose killing of a park worker at the start of the film sets the plot in motion, and the treacherous park employee Dennis Nedry, who hacks several park systems in order to distract the heroes while he smuggles dinosaur embryos from InGen to rival corporation BioSyn, leading to the escape of the Tyrannosaurus rex, among other dinosaurs, to attack the inspection crew and his employer John Hammond's grandchildren. Because he was the only one who could undo his own work (but wound up a casualty of his own sabotage when a Dilophosaurus kills him) and he left the Velociraptor exhibit untouched, the heroes' attempts to fix what he did lead to shutting the entire park down, which enables the pack under the "Big One" to become the final obstacle in the heroes' escape from Isla Nublar.
    • The Lost World: Jurassic Park: Peter Ludlow, the Evil Nephew of John Hammond, who is desperate to save InGen following the failure of Jurassic Park and responsible for their operations on Isla Sorna to ferry dinosaurs to an abandoned earlier Jurassic Park in San Diego. His actions there, in addition to him discrediting Ian Malcolm, reducing the chaos theorist to a pariah, are what drive the story in motion.
    • Jurassic Park III: While this film has no human antagonist, instead relying on encounters with other extinct animals, the Spinosaurus is the first predator that the main characters meet on Isla Sorna, and the most dangerous of the predators they have to escape from on that island.
    • Jurassic World: Another Big Bad Ensemble, this time involving the Indominus rex, a super-hybrid dinosaur made on the base genome of Tyrannosaurus rex who engineers its escape and causes havoc throughout Isla Nublar, and Vic Hoskins, the overseer to Owen Grady's Velociraptor training program who seeks to have the Velociraptor weaponized for the military, and whose secret partnership with Henry Wu leads to the creation of the aforementioned Indominus rex as a means to get InGen to agree to use the Velociraptor. Hoskins winds up killed by a Velociraptor near the end of the film, so the conflict only ends with the defeat of the Indominus rex.
    • Jurassic World: Fallen Kingdom: Eli Mills, the treacherous assistant to John Hammond's ex-partner Benjamin Lockwood, who opens a laboratory under Lockwood's basement right under his nose and tricks Owen Grady and Claire Dearing into helping him find the remaining Isla Nublar dinosaurs threatened by the cataclysmic eruption of Mt. Sibo under the guise of rescuing them, which is technically correct, just not for benevolent reasons, rather instead to start providing new genetic material and sell the dinosaurs in an auction. Another Big Bad Ensemble forms when an earlier operation on Isla Nublar recovered a bone from the Indominus rex, used to make its savage successor the Indoraptor, who the heroes have to defeat and prevent from being sold. Eli drives the plot in motion, and it only wraps up when he is defeated at the end.
    • Jurassic World Dominion: Lewis Dodgson finally takes center stage after having been the one who made the offer to Dennis Nedry. His company, Biosyn, has engineered a locust outbreak to get people to buy his products, and his capture of Maisie is what ropes Owen and Claire into stopping him.

    K 
  • Kick-Ass: Frank D'Amico, who is responsible for much of the crime in the city as well as being the one who framed Big Daddy and sent him to jail.
  • Kung Fury: Adolf Hitler, the Kung Fuhrer, who has come forward in time to battle Kung Fury for his power.
  • Kwaidan:
    • "The Black Hair": The samurai's first wife, who died after he left her and seeks a terrible vengeance.
    • "The Woman of the Snow": The Yuki-onna, a snow woman who freezes people to death.
    • "Hoichi the Earless": Emperor Antoku, who presides over a court of life-draining phantoms.
    • "In a Cup of Tea": Heinai Shikibu, a ghost seeking vengeance on the samurai who drank his soul.

    L 
  • The Lair of the White Worm: Lady Sylvia Marsh, a reptilian vampiress plotting to summon her dark god.
  • Land of Oz:
    • The Wizard of Oz: The Wicked Witch of the West, who menaces Dorothy throughout the film and serves as the biggest obstacle to her safe return home.
    • The Wiz: Eveline, a witch and sweatshop owner responsible for all of the obstacles that hinder Dorothy and her friends' journey on the Yellow Brick Road.
    • Return to Oz: The Nome King, the new ruler of Oz who usurped the throne in Dorothy's absence after finding the Ruby Slippers.
    • The Witches of Oz: The Wicked Witch of the West/Billie Westbrook, whose plan to get the key drives the plot.
    • Oz the Great and Powerful: A Big Bad Duumvirate between Evanora, the Wicked Witch of the East and Theodora, the Wicked Witch of the West. Though, Evanora is the films true Big Bad, being the one who manipulated Theodora into becoming evil in the first place.
  • The Last House on the Left: Krug Stillo, the leader of the gang who raped and killed Mari Collingwood and her friend, leading her parents, whose house they happen to be staying at, to seek revenge.
  • The Last King of Scotland: Idi Amin, a seemingly benevolent ruler of Uganda who his personal doctor, Nicholas Garrigan, gradually discovers is actually a brutal dictator oppressing the people of Uganda.
  • The Last of the Mohicans: Magua, who seeks vengeance on the family of Colonel Munro, putting him at odds with the Mohicans, the film's heroes.
  • The Last Samurai: Omura emerges as the main villain, who uses brutal and dishonest means to force through his own vision of Japan's future as a modern, ruthless Western-type industrial state (with himself in charge).
  • Little Evil: Satan, who plots to ascend to the Earth by having his son sacrificed.
  • Long Pigs: Anthony McAllister, a cannibalistic Serial Killer being filmed for a documentary.
  • Looney Tunes: Back in Action: The ACME Chairman, who seeks the Blue Monkey so he can use it to enslave mankind.
  • Lord of Illusions: Nix the Puritan, an Evil Sorcerer plotting to destroy the world.
  • The Lord of the Rings: The Dark Lord Sauron is the primary driver of the plot. As the trilogy begins, he is poised to conquer all of Middle-earth, and his victory will become assured if he captures the One Ring. He kick-starts the plot by sending the Ring-Wraiths to take the Ring from Frodo, he corrupts Saruman into attacking Rohan and kidnapping two of the heroes in the second film, and he musters a massive force to attack Gondor (and is mentioned in dialogue to be attacking all other good-aligned nations) in the third film. The plot isn't resolved until the Ring is destroyed, killing Sauron and leaving his forces leaderless and easily routed. In addition to him, Gollum, the previous bearer of the Ring before Bilbo, acts as a more direct threat to Frodo. Though while Gollum is able to be in an Enemy Mine with Frodo and Sam throughout the second film and guide them to Mordor in the third, his possessive desire to reclaim the Ring begins to take a hold as they get closer, and he betrays them when they are there, actually succeeding in grabbing the ring via biting Frodo's finger off, if only to fall into Mount Doom with it.
    • The Hobbit, as a prequel to The Lord of the Rings, has two major enemies that Bilbo, Gandalf, and the Thirteen Dwarves must face. The main driving force of the conflict is Smaug, the dragon that took over Erebor and drove out the dwarves to claim their gold and jewels. However, as Smaug doesn't directly encounter the dwarves yet, the first film in the series, The Hobbit: An Unexpected Journey sees Azog the Defiler, whom killed Thorin's grandfather Thror, and whose orcs took over Moria, Spared by the Adaptation with a severed arm courtesy of Thorin, and as the most direct threat faced in the film, pursuing the main characters throughout the film and nearly succeeding in catching them. In the second film, The Hobbit: The Desolation of Smaug, Azog remains in pursuit early in the film, before being revealed to answer to The Necromancer, and therefore stays at Dol Goldur while his son Bolg continues the pursuit of the heroes. The Necromancer is actually Sauron, planning a war long before the one that took place in The Lord of the Rings. The dwarves and Bilbo eventually arrive at Erebor, and they finally confront Smaug for the first time, though they are unable to kill him and prevent his attack on Lake-town. Smaug winds up a Disc-One Final Boss in the final film of the trilogy, The Hobbit: The Battle of the Five Armies, killed by Bard, and Sauron is promptly exiled to Mordor by the combined forces of Galadriel, pre-Face–Heel Turn Saruman, and Elrond, leaving Azog to lead the invasion over Erebor and confront the heroes one last time.
  • The Lost Boys: Max, a vampire pack leader trying to corrupt a family into joining him.
  • Lycan: Isabella's adopted mother turns out to be the real one. She's a killer and is implied to have turned Isabella into one too. As the last Burt, she's stated to be carrying on a legacy since Emily Bunt, who's been identified in legend as a murderous werewolf (whether real or not is unclear).

    M 
  • Macbeth: Macbeth, who murders King Duncan in order to take his place on the throne and kills anyone who comes close to finding out his crimes.
  • Machete: Rogelio Torrez, who intends to close the US-Mexican border so he can control the entire drug trade due to knowing all of the weak points.
    • Machete Kills: Luther Voz, the head of Voz Tech who plots to end the world by having nukes launched at every major country so he may start a new one made in his own image.
  • The Machine: Director Thomson decides to use the Machine as a weapon against her creator's wishes, and later holds the brain recording of Vincent's dead little girl hostage to get him to obey.
  • Mad Dog Morgan: Superintendant Cobham, the Corrupt Politican pursuing Morgan.
  • The Marksman: Mauricio, a high-level soldier with a Mexican drug cartel, is the film's main villain. He is a ruthless murderer who's hunting down a woman and her young son just to punish them for what her brother did (who is already dead at the cartel's hands while this happens after stealing from them).
  • Mars Attacks!: The Martian Emperor, who has ordered his planet's armies to destroy the Earth.
  • Martha Marcy May Marlene: Patrick, the leader of the cult whose rape of Martha serves as the source of her mental trauma.
  • Martyrs: The Mademoiselle, head of a cult of torturers seeking the answers to the afterlife.
  • Masquerade (2021): Initially it seems Rose is the one in charge as she's apparently giving instructions to the burglars. Ultimately Daniel is the main villain, responsible for murdering Casey's parents and setting her on a darker path.
  • Masters of the Universe: Skeletor, who has finally conquered Castle Grayskull and now seeks to uncover the secrets of the universe in order to become all-powerful.
  • Matilda: Agatha Trunchbull is a ruthless, child-unfriendly principal who has ruled over the elementary school Matilda studies in with cruelty, and shows no compassion towards anyone whatsoever (not even, and in fact especially not, towards her own niece Miss Honey). Matilda, after being mistreated for the longest time and seeing her classmates get mistreated as well, practices her new powers to prepare a plan to get rid of her.
  • The Matrix:
  • Meet John Doe: D. B. Norton, the owner of Ann's paper wishes to exploit the John Doe movement for his own cynical political ends.
  • The Meg: The titular shark that threatens the sea and that attacked Jonas Taylor.
  • Memento has Leonard Shelby, who willingly deludes himself into murdering people so that he can have a purpose in life.
  • Memoirs of an Invisible Man: David Jenkins, a corrupt CIA agent who hunts Nick down and intends to force him to serve them as a black ops assassin
  • Men in Black: An unnamed bug alien seeking a powerful energy source to win an intergalactic war.
    • Men in Black II has Serleena, the Queen of the Kylothians who she seeks out the Light of Zartha so she can use it to destroy Earth and Zartha and have her species rule the galaxy unopposed.
    • Men in Black 3 has Boris the Animal, the last of the Boglodites who travels back in time to kill K and kickstart an invasion on Earth, with J having to also go back in time to save K and prevent the invasion.
  • Mimic has the Judas breed insects kidnapping and devouring the citizens of Manhattan.
  • Mindhunters: Lucas Harper, the Serial Killer stalking the island.
  • Minority Report: Lamar Burgess. He killed Anne Lively when she was clean from drugs and wanted to get Agatha back, manipulated the Precogs' minority reports to get free from murder and framed John for getting too deep inside the Anne Lively case.
  • Misery: Annie Wilkes, an obsessed fan of Paul Sheldon who kidnaps him after his legs are broken in a car accident and forces him to write a novel that undoes the death of her favorite character while under her care.
  • Monsieur Verdoux: Henri Verdoux, who marries and murders women to care for his family.
  • Mortal Engines: In a change from the novels, Thaddeus Valentine is the sole example here. He plans to recover MEDUSA and use it on the rest of the world to make London pre-eminent, murders Pandora and Crome when they try to stand against him and is ultimately responsible for the devastating attack on Shan Guo.
  • Mr. Arkadin: Gregory Arkadin, a Georgian arms-dealer who wants to wipe out all traces and memory of Wasaw Athabadze, his real name and identity, by tracking down and killing all who knew him.
  • Mr. Smith Goes to Washington: Senator Joseph Paine and James Taylor are the Corrupt Politicians who control a vast political machine and want to dam a major river, which would destroy the natural attractions that Mr. Smith wants to preserve.
  • Mutant Girls Squad: The Prime Minister of Japan, who has started a campaign of genocide against a bunch of mutants.

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