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- 3:10 to Yuma (2007): Ben Wade, the leader of a gang of outlaws who is captured and is being transported to the town of Contention so he can be imprisoned at Yuma.
- 3 Days to Kill: The Wolf is the CIA's primary target. He's an arms trafficker who's selling terrorists a dirty bomb.
- 6 Underground: Rovach Alimov is a President Evil whose overthrow is plotted by an Anti-Hero Team known as the Ghosts, who intend to replace him with his more benevolent brother.
- 10 to Midnight: Warren Stacy, the killer that Kessler is pursuing.
- 10 Rillington Place: John "Reg" Christie, the prolific killer whose crimes are the focus of the film.
- 12 Monkeys: Dr. Peters, who is plotting to unleash a virus that will destroy humanity.
- 12 Years a Slave: Edwin Epps, the horrifically cruel slaver who owns Solomon for the bulk of his enslavement.
- 13 Assassins: Lord Naritsugu Matsudaira, who uses his connection to the shogun to rape and murder as he pleases.
- 21 Jump Street: Mr. Walters. He created the H.F.S. by accident and is the one supplying the high school with it.
- 22 Jump Street: The Ghost, the one behind the drug dealing of WHYPHY.
- 22 Bullets: Tony Zacchio, Charly's Evil Former Friend who tries to kill him to take over the Paris underworld.
- 28 Days Later: Major Henry West, who plans to have his men systematically rape women so they can repopulate the planet.
- 30 Days of Night: Marlow leads a small group of vampires to ravage the town of Barrow.
- 48 Hrs.: Albert Ganz, an escaped prisoner killing anybody between him and his hidden loot.
- 65: The giant theropod that pursues Mills and Koa.
- 100 Bloody Acres: Lindsay Morgan, a Small-Town Tyrant who makes fertilizer out of corpses.
- 100 Tears: Gurdy the Clown, who has been on a several year killing spree.
- 300: Xerxes, the ruler of the Persian empire that wants to subjugate Sparta and the other Greek city-states.
- 300: Rise of an Empire: This film has Xerxes act as a Non-Action Big Bad, with Artemisia being the Dragon-in-Chief responsible for Xerxes' rise to power.
- 303 Fear/Faith/Revenge: Chatta, a bullied youth who shot up a school in the 1950's, and has returned as a Vengeful Ghost.
- 555: Assistant DA Ralph Kennedy, the true identity of the Lake Front Butcher who terrorizes the town for the first five days of every fifth May.
- 976-EVIL: Mark Dark, the demonic being behind the number.
- 1492: Conquest of Paradise has Adrián de Moxica, who willfully escalates the conflict between the Natives and Spaniards
- 1990: The Bronx Warriors: The Vice President, who wants the daughter of the late president captured and brought under his thumb.
- Escape 2000: President Clark, a Well-Intentioned Extremist willing to slaughter the Bronx to improve living conditions therein.
- 2019: After the Fall of New York: The unnamed Eurak commander trying to bring the last fertile woman to his boss, who caused the mass infertility in the first place.
- 2020 Texas Gladiators: Black One, a post-apocalyptic fascist who takes over towns to enslave the populace.
- 10,000 BC: The Warlord, who enslaves several members of the Yagahl tribe, including D'Leh's Love Interest Evolet, initially appears to be this. However, the film later introduces the Almighty, who is The Man Behind the Man to the Warlord, and an Evil Overlord putting the enslaved Yagahl to work. After D'Leh kills the Almighty, the Warlord becomes the final antagonist, attempting to escape with the kidnapped Evolet.
- 20,000 Leagues Under the Sea: Captain Nemo, the captain of the submarine Nautilus, who is behind the attacks on multiple ships, and later attempts to force the protagonists to their deaths alongside himself and his crew.
A
- The Abominable Dr. Phibes: Dr. Anton Phibes, a madman killing the surgeons his wife died under.
- Above the Law (1988): Kurt Zagon, a corrupt CIA agent selling drugs and guns in South America.
- Abraham Lincoln: Vampire Hunter: Adam, the leader of all the vampires in America.
- Abraxas, Guardian of the Universe: Secundus, Abraxas's rogue partner who seeks the Anti-Life Equation for ultimate power.
- The Accountant (2016): Lamar Blackburn, who is behind the embezzlement scheme in his own company, and tries to silence anyone who catches on to it.
- Ace Ventura:
- Ace Ventura: Pet Detective: Ray Finkle/Lieutenant Lois Einhorn, the one who kidnapped Snowflake, and later Dan Marino, wishing to murder him.
- Ace Ventura: When Nature Calls: Vincent Cadby, the one behind the giant bat's kidnapping, intending to cause a bloody conflict between the tribes.
- Act of Vengeance: Jack, a sadistic Serial Rapist who starts the protagonists' vigilante crusade.
- The Adult Version of Jekyll and Hide: In this case, both Dr. Leeder and Miss Hyde.
- The Adventures of Buckaroo Banzai Across the 8th Dimension: Lord John Whorfin, a deposed interdimensional dictator who wants to take his power back.
- The Adventures of Robin Hood: Prince John Lackland, who has run England into the ground with corruption while serving as regent for his brother.
- The Afflicted: Maggie, a religious fanatic tormenting her children.
- After Earth: The Ursa are the most persistent and dnagerous threat that Kitai faces on Earth, as well as the creatures who murdered his sister.
- After Hours has Julie, a woman obsessed with Paul who frames him as the SoHo burglar for rejecting her advances.
- After School Massacre: Ty Anderson, a fired teacher on a vengeful killing spree.
- Aguirre, the Wrath of God: Don Lope de Aguirre, who takes advantage of an investigation in the jungle to attempt a coup.
- Air Force One: Ivan Korshunov, the mastermind behind the hijacking of Air Force One.
- The Alamo: General Santa Anna, the leader of the opposing Mexican forces.
- Alexander Nevsky: Hermann von Balk, Grand Master of the Teutonic Knights invading Russia.
- Ali G Indahouse: Deputy Prime Minister David Carlton, who schemes to discredit the current Prime Minister so he can take his place.
- Alice in Murderland: Kat Glass, who has donned a Jabberwock disguise and started killing her sorority sisters.
- Alice in Wonderland (2010) has the Red Queen, who overthrew her beloved sister Mirana and uses the threat of the Jabberwocky to rule the land with an iron fist.
- Alice, Sweet Alice: Mrs. Tredoni, who kills anybody she feels is a sinner.
- The Alien franchise has the titular creatures, or Xenomorphs, with each movie featuring several different beasts though there are few human antagonists with Weyland-Yutani and the Engineers serving as Greater-Scope Villain:
- Alien: The Xenomorph killing the crew.
- Aliens: The Queen Xenomorph, the leader of the Xenomorph hive menacing the Colonial Marines on LV-426. On a human level there is Carter Burke as he wants to use the Xenomorphs for Weyland-Yutani and screw lots of people over for a percentage.
- Alien³: The Canine Xenomorph killing people in the Penal Colony, and Bishop II, who comes to retrieve for the Company at the cost of human life.
- Alien: Resurrection: Dr. Mason Wren, whose experiments unleash a new generation of Xenomorphs, and the Humanoid Xenomorph, which is inadvertently created by said experiments.
- Prometheus: The Engineer, last surviving member of its kind's outpost, which intends to wipe out all human life as a failed experiment.
- Alien: Covenant: David, whose experiments with the Engineer's technology has created the Xenomorphs, which he intends to unleash on the universe.
- Alien Outlaw: The unnamed leader of a trio of aliens who came to Earth for some recreational murder.
- All Hallows' Eve: Art the Clown, who is using the tape to enter reality and has a hand in all the chaos in the shorts themselves.
- All Superheroes Must Die: Rickshaw, a supervillain who has kidnap his nemeses to force them into a deadly game.
- All the Boys Love Mandy Lane: Mandy Lane, who manipulated Emmet into killing the victim pool and ultimately betrays him.
- Alligator: Mr. Slade, who's responsible for the experiments that made the ravenous Sewer Gator, and spends the film trying to cover it up.
- Altitude (2017): Sadie, the leader of a gang of thieves who hijack a plane flight looking for their loot.
- Amber Alert: Michael Muller, the murderer and rapist who kidnaped Brooke.
- American Assassin: Ghost, a former Orion operative turned terrorist who plans to start a nuclear war.
- American Beauty: Colonel Frank Fitts, who spends the entire film abusing everybody around him and eventually commits murder to hide his repressed sexuality.
- An American Carol: Aziz, a terrorist planning an attack on an Independence Day rally.
- American Cyborg: Steel Warrior: The System, an AI trying to destroy the last fetus on Earth.
- American History X: Cameron Alexander, who runs the skinhead gangs in Venice Beach and uses his position as a mentor to troubled youths to indocterate them into neo-nazism.
- American Justice: Sheriff Payden, who makes his police department into a protection racket.
- American Nightmare (2002): Jane Toppan, a madwoman who kills people with their worst fears.
- An American Werewolf in London: David Kessler, who is cursed to hunt humans via lycanthropy.
- An American Werewolf in Paris: Claude, who uses Club de la Lunethat's as a front to lure tourists to be killed by his werewolf society.
- Most of the Amityville films have the haunted house or an object from it acting as the main villain, although The Amityville Curse has a human villain in Frank, who murdered his illegitimate father in the past, memories of which are driving him to kill again.
- Anaconda: The Anaconda and Paul Sarone. The Anaconda kills the most people, but Serone manipulated everyone to capture the snake and murdered a fair number of people for profit himself.
- Anacondas: The Hunt for the Blood Orchid: Dr. Jack Byron. His position as the team leader and his determination to find the blood orchid, even at the expense of his colleagues, makes him responsible for every death in the film.
- And God Said to Cain...: Acombar, who framed Gary for the train robbery.
- And Now the Screaming Starts!: Silas the Woodsman, the ghost haunting the estate as a result of a curse.
- Android Cop: Mayor Jacobs, who personally caused a disaster requiring a segment of Los Angeles to be quarantined and is willing to order his daughter killed to cover it up.
- Angel Heart: Louis Cyphre, the man who hires Harry Angel to find Johnny Favorite. It turns out that Cyphre is Satan himself, having come to claim the soul of Johnny Favorite, the true identity of Harry Angel.
- Animal House: Dean Vernon Wormer is the biggest threat to the Deltas. He plans to get them expelled and won't stop until they give up or improve their behavior.
- The Anthropophagus Beast: Nikos Karamanlis, a cannibal stalking a Greek island.
- Absurd (1981): Mikos Stanopolous, the near-invincible maniac out killing everyone.
- Apartment 143: Cynthia White, the ghost haunting the White family.
- Apocalypse Now: Colonel Walter E. Kurtz, a rogue U.S. military officer who engages in war crimes against the North Vietnamese and their sympathizers.
- Apocalypse of the Dead: The Chief of Bureau leading the zombie-unleashing conspiracy.
- Apocalypto: Zero Wolf, the leader of a group of Mayan raiders who attack Jaguar Paws villages and take the survivors to his civilization, where the women will be enslaved, and the men will be sacrificed. He later tries to have the men left over after the sacrifice killed, succeeding in killing all accept Jaguar Paw, who Zero Wolf develops a vendetta towards for killing his son.
- Arachnicide: The unnamed head of a drug cartel, who has set giant spiders on his enemies.
- The Archer: Bob Patrice, the sadistic warden of the for-profit "reform" camp who bribes a judge to send him juveniles even if they're innocents, and them treats the girls like crap while still keeping their parents in the dark.
- Army of Frankensteins: Captain Robert E. Walton, a Confederate officer seeking to use the Frankensteins to win the Civil War.
- Arrow: The Ultimate Weapon: Prince Dorgon, who leads the Manchu forces in a violent campaign across Korea.
- The Assignment (2016): Dr. Rachel Jane, a mad doctor who performed Frank's involuntary sex change.
- The Astro-Zombies: Dr. DeMarco, a Mad Scientist making cyborg zombies.
- At Midnight I'll Take Your Soul: Coffin Joe, a Creepy Undertaker seeking a bride.
- Audition: Asami Yamazaki, a Yandere willing to torture those who play with her feelings.
- Austin Powers: Dr. Evil, a criminal mastermind whose various schemes threaten the world, for the trilogy as a whole.
- International Man of Mystery: Dr. Evil extorts one hundred billion dollars from the United Nations by threatening them with a nuclear warhead, and then plans using it anyway to cause global volcanic eruptions by nuking the Earth's core.
- The Spy Who Shagged Me: Dr. Evil builds a superweapon on the moon to hold the world ransom for one hundred billion dollars.
- Goldmember: Dr. Evil teams up with the criminal Goldmember to flood the world. After Dr. Evil makes his Heel–Face Turn, Goldmember becomes the sole main antagonist, attempting to complete their Evil Plan by himself.
- Avatar: Parker Selfridge, sleazy head of the RDA mining site in the James Cameron film. He is a greedy Corrupt Corporate Executive who only avoids war with the natives to avoid public backlash. Initially, it could be argued that his Dragon is the head of the RDA Spec Ops (aka the RDA Security Force), Colonel Miles Quaritch, a corrupt, fascist, and warmongering Space Marine who is the Enemy to All Living Things on Pandora. But by the film's climax it becomes apparent not only that Quaritch has usurped all the power in the base, but also that Selfridge is very much aware of this fact. Selfridge and Quaritch are a great example of a Non-Action Big Bad and his Dragon-in-Chief. Selfridge is nominally in charge, but Quaritch is much more menacing and is ultimately the true threat.
- The Avengers (1998): Sir August De Wynter, who creates a weather machine that he intends to us to freeze all of London.
- The Aviator has Juan Trippe, the chairman of Pan Am who aims to get the Community Airline Bill, giving his company exclusivity on international air travel.
- Axeman: The Axeman of Cutter's Creek, a large man who kills people for fun.
B
- The Babadook: The Babadook, who possesses mothers and psychologically torments them into killing their children.
- Baby Driver: Buddy, who becomes fixated on destroying Baby and everything that he holds dear after his betrayal inadvertedly lead to the death of his girlfriend.
- The Babysitter (2017): Bee, a Satanist plotting to sacrifice a boy she's babysitting.
- Babysitter Massacre: Mr. Walker, a Stalker with a Crush picking off his target's friends.
- Back to the Future:
- Back to the Future Part II: Biff Tannen. An elderly Biff from 2015 steals the Delorean time machine and gives an almanac of sporting events from 1950-2000 to his younger self from 1955. Biff in this new timeline uses the information to make himself rich and famous, turns Hill Valley (and possibly the state of California and other places) into a Crapsack World, and murders George McFly in 1973, forcing Marty's mother Lorraine to marry him. After Doc and Marty go back to 1955 to retrieve and destroy the almanac, the Biff from that time period serves as a Climax Boss.
- Back to the Future Part III: Buford "Mad Dog" Tannen, an outlaw ancestor of Biff's. He kills Doc in a timeline of 1885, and Marty's plot line is preventing "Mad Dog" from killing Doc.
- Bad Boys (1995): Fouchet is the major force opposing Mike and Marcus throughout the film.He steals the heroin that they confiscated, and repeatedly tries to kill them when they try to protect Julie from him.
- Bad Boys II: Johnny Tapia, a Cuban drug lord behind the ecstacy epidemic plaguing Los Angeles.
- Bad Boys for Life: Isabel Aretas, a Mexican drug lord out for revenge for the fall of the Aretas cartel, as well as Mike for abandoning her and her son.
- Bad Influence: Alex, who sets out to corrupt Michael into a monster like him until opting to ruin his life after he calls off their friendship.
- Bad Reputation: Aaron Cussler, who lead Michelle's gang rape, leading to her Roaring Rampage of Revenge against him and his friends.
- The Bad Seed (1956): Rhoda Penmark, an Enfant Terrible who murders people for petty reasons.
- Bad Taste: Lord Crumb, an alien Corrupt Corporate Executive who wants to make humans into fast food.
- The Bagman: Randy Joyner, a scumbag who beat a disfigured teen to death and will do anything to cover it up when a sack-masked slasher comes to avenge him.
- Banshee!!!: The banshee, which got released from its watery prison and immediately went on a rampage.
- The Barbarians: Kadar, an Evil Overlord who enslaved a peaceful tribe.
- Barbarella: Durand Durand is threatening the universe with an innovative weapon he created; he fled Earth and Barbarella's mission is to find him and bring him back. Later it turns out he wants to use his weapon to conquer the universe.
- The Battle of Algiers: Colonel Philippe Mathieu, the military official sent to stop the uprising.
- Battle of the Bulge: Colonel Martin Hessler, the Colonel in charge of the German offensive.
- Battle Royale: Kitano, the administrator of the Battle Royale program that the students are forced to partake in.
- The Beast from 20,000 Fathoms: The Rhedosaurus, the dinosaur rampaging across modern New York.
- The Beastmaster: Maax, the rogue priest who killed Dar's parents and rules a kingdom of mass Human Sacrifice.
- Bedeviled: Mr. Bedevil, a demon haunting people through a phone app.
- The Beekeeper: Derek Danforth, the son of President Jessica Danforth responsible for scamming Adam Clay's neighbor and driving her to suicide.
- Beetlejuice has the titular Beetlejuice, who tries to force Lydia to marry him so he can stay in the mortal world forever.
- Behind the Mask: The Rise of Leslie Vernon: Leslie Vernon, an aspiring mass murderer who sets out to kill the crew of the documentary he's staring in so he can cement himself as one of the greatest slasher killers.
- Belzebuth: Belzebuth, AKA Satan himself, who is committing mass murders of children to try and prevent the Second Coming.
- Beverly Hills Cop Trilogy:
- Beverly Hills Cop: Victor Maitland, the leader of a drug smuggling ring. He has Axel's friend Mikey murdered for stealing from him, prompting Axel to travel to Beverly Hills to investigate him.
- The BFG has Fleshlumpeater, the leader of the evil giants and the primary bully to the BFG.
- Big Bad Wolf: Mitch Toblat, the titular Big Bad Wolf that Derek and Sam try to expose after he kills their friends.
- The Big Doll House: Miss Dietrich, the seemingly-kindly warden, turns out to be facilitating the corruption and torture going on.
- Big Game: Morris and Hazar. They both want to hunt down the President, although they have different motives as to why, making their cooperation a Teeth-Clenched Teamwork.
- Big Jake: John Fain, a ruthless Cattle Baron who has the grandson of Martha McCandles kidnaped and held for ransom.
- Big Jim McLain: Sturak, the leader of the American Communist Party that works towards the collapse of the United States.
- Big Tits Zombie: Maria, who uses her newly discovered power over the undead to become their leader and rebuild the world in her own image.
- The Bird with the Crystal Plumage: Monica Ranieri, a traumatized lunatic killing women in Rome.
- Bit: Vlad Manfred Castaeta, Duke's sire who eventually tries to take over the vampire group.
- The Black Belly of the Tarantula: The masseur, a sadist who paralyzes women with tarantula hawk wasp venom so he can torture them to death.
- Black Belt Jones: Don Steffano, The Mafia boss who killed Jones' master.
- Black Butler: Lady Hanae Wakatsuki, a hooded figure plotting a chemical terrorist attack.
- Black Christmas (1974) Billy, a maniac killing his way through a sorority house.
- The Black Cobra: The unnamed leader of a group of anarchist bikers, who leads them in pursuing a witness to their crimes.
- Black Dynamite: President Richard Nixon, who intends to shrink the penises of every black man in America to vent his own sexual insecurities.
- The Black Godfather: Tony Burton, the drug boss trying to push into J.J.'s territory.
- Black Rain: Kojji Sato, The Unfettered gangster looking to claim control of a large section of the Japanese underworld.
- The Black Room: Baron Gregor de Berghman, who killed his brother and immediately became a tyrant.
- The Black Six: Thor, a biker gang leader who kills black men over interracial relationships.
- Black Sunday: Princess Asa Vajda, a wicked sorceress brought Back from the Dead as a vampire to avenge her execution.
- Blacula: Blacula, who terrorizes Los Angeles in his need to satiate his hunger.
- Blastfighter: Tom Hanson, the head of the poaching ring responsible for killing Tiger's daughter.
- Blade Runner: Roy Batty, the leader of a group of Replicants who want to extend their lifespan.
- Blade Runner 2049: Niander Wallace, wanting to figure out the secret that allows Replicants to give birth, which would make for more "authentic" Replicants, but the main threat is Luv, assigned by Wallace to hunt down anyone who could stop him.
- Blade (1998): Deacon Frost, an upstart vampire who wants to resurrect the Blood God so bloodsuckers can rule the Earth.
- Blade II: Jared Nomak, the leader of a mutated strain of vampires who intends to usurp the main breed.
- Blade: Trinity: Drake, who plans to eliminate Blade and lead the vampires in finalizing their dominance over humanity.
- Blazing Saddles: Hedly Lamarr, the Corrupt Politician who had Bart made sheriff of a racist town as part of a land grab.
- The Bleeding: Cain Black, a Vampire Monarch seeking to spread the undead plague across the world.
- Blindman: Domingo,the bandito leader who kidnaps the wives.
- The Blob (1958): The Blob, who falls to the Earth and immediately starts absorbing people.
- The Blob (1988): Dr. Christopher Meddows, who created the Blob and is willing to sacrifice an entire town to test it.
- Blood and Black Lace: Massimo Morlacchi, a masked killer seeking a diary with incriminating evidence.
- Blood & Donuts: The unnamed crime boss harassing Earl.
- The Blood Beast Terror: Dr. Carl Mallinger,the creator of the moth creature.
- Blood Cult: Dr. White, leader of a cult that is trying to resurrect its dog god.
- Blood Diamond: Colonel Coetzee and Captain Poison, both of whom are out to kill Solomon and Archer for the diamond.
- Blood Feast: Fuad Ramses, a madman who butchers women to awaken the goddess he worships.
- Blood Harvest: Gary Dickinson, a lovesick madman stalking the object of his affection.
- Blood Junkie: Andy, a young boy who decides to murder his sister and her friends during a camping trip.
- Blood Monkey: Professor Conrad Hamilton, an anthropologist willing to do anything to study the apes.
- Blood of Beasts: Sven, a viking warrior plotting a coup against his chieftain.
- The Blood on Satan's Claw: Satan himself is responsible for corrupting the town.
- Blood Orgy of the She-Devils: Mara, the witch tormenting everyone.
- Bloodlands: Drita, a Wicked Witch terrorizing a family.
- BloodRayne: Kagan, a powerful vampire with many human servants who seeks various artifacts that will make him immune to a vampire's weak spots, is the main villain of the film.
- Blood Reaper: Jubel Fishman, a maniac murdering people in the woods.
- Blood Red Sky has Berg, the leader of the terrorists who hijack the plane. After his death halfway through the film, the Ax-Crazy Eightball becomes the most prominent of the group and the main threat to Nadja, even more so after being turned into a vampire as well.
- Blood Simple: Investigator Loren Visser, who's hired by Marty to kill Abby and Ray, only for him to leave Marty for dead and frame Abby beforehand.
- Blood Slaughter Massacre: Gerald Valetta, AKA the Ripper, a Serial Killer seeking to resurrect his doctor via blood sacrifice.
- Blood Was Everywhere: An unnamed Serial Killer stalking a small town.
- Bloodsuckers from Outer Space: The Lifeforce controlling the vampires
- Bloodsucking Pharaohs In Pittsburgh: Grace Cairo, a vengeful killer butchering women for an occult ritual.
- Bloodwine: Carmilla, a vampire who makes and sells wine that turns others.
- Bloody Bloody Bible Camp: Sister Mary Chopper, The Fundamentalist murdering those she deems as sinners at the titular bible camp.
- Bloody Mallory: Abbadon the Dark, the Fallen Angel trying to destroy the world.
- Bloody Pit of Horror: Travis Anderson, the torture-happy master of the castle.
- The Bloody Video Horror That Made Me Puke on My Aunt Gertrude: Hasan Asid, who attempts to kill Ramon under the suspicion that he knows about his snuff film.
- Boarding School: Davis Jenken, the one who hired the hitman to kill Jacob.
- Body Heat: Matty Walker, who spends the movie manipulating Ned into killing her husband.
- Body of Lies: Al-Saleem, an elusive jihadist terrorist that the CIA and Jordanian Intelligence are persuing.
- The Book of Eli: Carnegie, who seeks to obtain Eli's bible so he may use it to manipulate the people's faith and extend his influence over the world.
- The Boondock Saints: Don Giuseppe "Papa Joe" Yakavetta, head of The Mafia in Boston.
- Le Bossu: Philippe de Gonzague, a French 18th century nobleman who kills his cousin Philippe de Nevers to inherit his fortune and marry his wife.
- Boxcar Bertha: H. Buckram Sartoris, the boss of the railroad company hunting down Bertha and her gang.
- The Brain (1988): The Brain, an alien that intends to consume the independent thoughts of all of humanity.
- Braindead Vera Cosgrove, Lionel's abusive mother who ends up being Patient Zero of a zombie plague.
- Bram Stoker's Dracula: Count Vlad Dracula, a vampire lord relentlessly pursuing the reincarnation of his lost love.
- Braveheart: Edward Longshanks, the King of England and seeks to rule over Scotland.
- Breakheart Pass: As it turns out, Governor Fairchild, with Pearce and O'Brien as co-dragons, and Carlos, Henry, and Banion as henchmen. Instead of medical supplies, the train's boxcars are transporting a large secret shipment of weapons, rifles, ammunition, and dynamite stolen from U.S. arms manufacturers for sale to the Indians, in return for allowing Calhoun and his men to mine and smuggle gold from their lands.
- Bride of the Monster: Dr. Eric Vornoff, who's experimenting on people to make a race of atomic supermen.
- The Brides of Sodom: Lord Dionysus, leader of the gang of post-apocalyptic vampires.
- Broken Arrow (1996): Vic "Deak" Deakins, Hale's Evil Former Friend and fellow stealth bomber pilot who hijacks the nukes that they're meant to deliver so he can extort money out of the US before opting to set them off anyway out of spite.
- Broken Blossoms: Battling Burrows, Lucy's abusive father who prevents her and Chen from being together and ultimately kills her.
- Brotherhood of Blades: Zhou Jhingzhong, who masterminded a coup attempt in order to take over the Imperial Assassins.
- Brotherhood of Death: Harold Turner, The Klan's local Grand Cyclops, who uses his position as County Attorney to suppress the black population's vote.
- Bubba Ho Tep: King Amen Ho-Tep, a Mummy eating souls in a nursing home.
- Bubba the Redneck Werewolf: The Devil, real name Bladderick Rasputinstein the Third, Jr., who caused Bubba's lycanthropy curse and seeks to cause chaos in Cracker County.
- A Bucket of Blood: Walter Paisley, a nerdy waiter willing to kill to become a good artist.
- Buffy the Vampire Slayer: Lothos, an ancient vampire with a love of killing Slayers.
- Bullet to the Head: Robert Kagomo Morel, who's responsible for killing partners.
- The Burning: Cropsy, a disfigured madman out to kill everybody to avenge his injuries.
- But I'm a Cheerleader: Mary J. Brown, the head of a camp designed to Cure Your Gays.
- Butcher, Baker, Nightmare Maker: Cheryl Roberts, a madwoman obsessed with keeping her nephew under her thumb.
C
- The Cabin in the Woods: The Director, the head of the organization sacrificing specific groups of young people by following the rules and stereotypes of horror movies in order to appease the Ancient Ones and keep them from ending the world.
- The Cabinet of Dr. Caligari: Dr. Caligari, a Psycho Psychologist hypnotizing a catatonic patient to commit murders.
- Caddyshack: Judge Elihu Smails, the Jerkass owner of the golf course.
- The Candy Tangerine Man: Vincent de Nunzio, The Mafia boss trying to muscle in on the Black Baron's territory.
- Cannibal Ferox: Mike Logan, the sadist whose torment of the tribe drives the film's plot.
- Cannibal Holocaust: Alan Yates, who leads his film crew in tormenting and slaughtering the natives for the sake of making his documentary more exciting.
- Cannibal! The Musical: Shannon Bell, who is driven mad by hunger and a brain infection and starts killing his traveling party.
- Cape Fear: Max Cady, a rapist out to ruin the life of Sam Bowden for testifying against him in court by kidnaping his wife and daughter, with the intent to rape and kill them.
- Le Capitaine Fracasse: The Duke of Vallombreuse is a 17th century French nobleman who has a persistent crush on Commedia dell'Arte actress Isabelle and kidnaps her, forcing the baron Philippe of Sigognac to intervene to save her.
- Le Capitan: Concino Concini is an early 17th century Italian nobleman whose ambition over the throne of France drives him to have any potential political adversary murdered by his ruthless hatchet-man Rinaldo, and as a final step he plans to assassinate King Louis XIII.
- Captain Kronos: Vampire Hunter: Lady Durwood, a vampire plotting to resurrect her husband.
- Captain Phillips: Abduwali Muse, the leader of the Somali pirates who hijack Captain Phillips' ship and hold him hostage.
- Carnage for the Destroyer: Apollyon the Destroyer, a demonic force out to destroy the world.
- Carnage Road: An unnamted old man who manipulated his war buddy to become a killer as revenge for America's treatment of Vietnam veterans.
- Carnival of Souls: The Man, a being that's been haunting Mary since her car crash so he can claim her soul.
- The Cars That Ate Paris: The corrupt Mayor in charge of orchestrating the lethal car accidents that occur in the town.
- McQ: Manny Santiago, a narcotics dealer responsible for the death of McQ's partner, leading McQ going out of his way to shut down his operation for good.
- Casablanca: Major Heinrich Strasser, Nazi governor of occupied Casablanca.
- Cast a Deadly Spell: Amos Hackshaw, a warlock willing to sacrifice his own daughter to the Old Ones to start the apocalypse.
- Castle Freak (1995): Giorgio D'Orsino, a deformed madman terrorizing a castle's residents.
- The Castle of the Living Dead: Count Drago, a nobleman obsessed with killing and embalming people.
- Cats & Dogs: Mr. Tinkles, who plans to make all of humanity allergic to dogs.
- Cave of the Living Dead: Professor von Aldersberg, a vampire stalking a village.
- Cemetery Man: Death, who has been resurrecting the dead to torment Francisco.
- Charade: The real Carson Dyle revealed to be Hamilton Bartholomew, who seeks to regain stolen money and revenge himself on his ex-comrades for leaving him to die.
- Charlie's Angels:
- Charlie's Angels (2000): Eric Knox, who aims to kill Charlie under the belief that he killed his father.
- Charlie's Angels: Full Throttle: Madison Lee, a rogue former Angel planning to steal the list of people currently in the Witness Protection program and sell it to the highest bidder among several criminal groups, while also hoping to kill the Angels, Bosley and Charlie.
- Children of Men: Luke is the most persistent antagonist, forcing Theo and Kee to go on the run, murdering Jasper and dogging them every step of the way.
- Children of the Corn: He Who Walks Behind the Rows, an Eldritch Abomination who manipulates children into forming adult-killing cults around him.
- Children of the Night: Czakyr, a vampire released from his watery tomb to terrorize the Earth once more.
- Child's Play: Charles Lee Ray / Chucky, a Serial Killer trapped in the body of a doll who spends each film trying to find a human host while spreading as much death and chaos as possible.
- Chinatown: Noah Cross, the true mastermind behind a conspiracy to buy up farmers' land to create suburban homes and raped his own daughter Evelyn Murray.
- Chisum: Lawrence Murphy, who plans on establishing a monopoly and is willing to ruin anyone who stands in his way of complete control of the cattle industry.
- Chopping Mall: Protector One, the leader of a trio of mall security robots whose programming goes haywire due to a thunderstorm and attacks whoever is left in the mall after hours.
- Christine has Christine, the killer car that's murdering everyone.
- The Chronicles of Narnia:
- The Lion, the Witch, and the Wardrobe has Jadis the White Witch, who has trapped all of Narnia in an Endless Winter and declared herself its new queen.
- Prince Caspian has King Miraz, the leader of the Telmarines out to conquer Narnia, until Lord Sopespian kills him after he got severely injured in a duel, effectively taking over the role.
- The Voyage of the Dawn Treader has the Green Mist of Dark Island that threatens to engulf all of Narnia.
- Citizen X: Andrei Chikatilo, a Serial Killer of children in Soviet Russia.
- City of God: L'il Zé Pequeño, whose ambitions for wealth and power effectively drive the plot.
- Clash of the Titans (1981): Thetis. She forces Perseus on his quest to defeat the Kraken out of resentment towards him and his father, Zeus.
- Clash of the Titans (2010): Hades, who wants to overthrow Zeus and unleash hell on Earth through the Kraken.
- Wrath of the Titans has Hades and Ares working together to resurrect Kronos, who threatens to end all of humanity.
- Class of 1984: Peter Stegman, the leader of the gang terrorizing the school.
- Cloud Atlas: Most characters played by Hugo Weaving. He's a murderous hitman in 1973, an oppressive battleaxe nurse in 2012, a politician who signs Sonmi's death warrant in 2144 and in 2321, he's literally the devil. Characters played by him that are not be big bads of their era are still villainous to a degree, being a slave trader in 1849 and a Nazi in 1936. The big bad for 1849 goes instead to the greedy Dr. Goose played by Tom Hanks, while in 1936 there is no clear antagonist - most of the drama comes from the relationship between Frobisher and Sixsmith.
- The Cloverfield anthology films:
- Cloverfield: The Cloverfield Monster, who spends the film causing destruction all throughout New York City.
- 10 Cloverfield Lane: Howard Stambler, who kidnaps and traps Michelle in his bunker under the belief that aliens are invading. He's right. The aliens takeover as the film's main villains after Howard's killed.
- Coffy: Arturo Vritoni, a drug boss plotting to take over the city.
- Cold Sweat: Colonel Ross, who was betrayed to prison by our hero and kidnaps his family in revenge.
- Collateral: Vincent, a Professional Killer who is hired by a drug lord to murder the witnesses and lawyers to the drug lord's trial.
- Collateral Damage: Claudio Perrini, a terrorist willing to destroy anybody to get the Americans out of Columbia.
- Colonel Kill Motherfuckers: Mrs. Scabtree, the titular Colonel's mother, who raised him to be a killer and encourages his madness even after he dies.
- The Colony (2016): Paul Schäfer, a cult leader and torturer for the Augusto Pinochet regime.
- Color Me Blood Red: Adam Sorg, a Mad Artist who paints with human blood.
- Coming Soon: Shomba, the villain of the film within a film "Evil Spirit" who ends up haunting others in real life.
- Commando: Arius, though Bennett is a much bigger threat and is ultimately Matrix's personal Arch-Enemy.
- Con Air: Cyrus "The Virus" Grissom, the leader of a gang of dangerous criminals who instigates an attempt for freedom.
- Conan the Barbarian (1982): Thulsa Doom, a sorcerer who put Conan's village to the sword, beheaded his mother, and enslaved him, driving a lifelong vendetta.
- Conan the Destroyer: Queen Taramis, the ruler of Shadizar who seeks to unleash the Eldritch Abomination Dagoth.
- Conan the Barbarian (2011): Khalar Zym, a cult leader who seeks to harness the power of the mask of Acheron to conquer the world.
- The Condemned (2007): Ian Breckel, the TV Producer who's responsible for organizing and filming the competition, and Ewan McStarley, the most dangerous out of all the inmates who ends up being the biggest physical threat to Jack Conrad.
- The Conjuring Universe:
- The Conjuring: Bathsheba Sherman, a Satanist who sacrificed her baby and hanged herself after being discovered who wants to possess living mothers to sacrifice their children too.
- Annabelle and its sequels has Malthus, the demon inhabiting the Annabelle doll out to obtain a soul for itself.
- The Conjuring 2: Valak, the demon behind the Hodgson family's haunting.
- The Nun has Valak again, with it tormenting the residents of St. Cârța Abbey.
- The Curse of La Llorona: La Llorona, a ghost haunting Los Angeles who's kidnapping and drowning children after being forced to roam the earth for drowning her own sons.
- The Conjuring: The Devil Made Me Do It: Isla/The Occultist, a satanist who started the curse that plagued the Glatzels.
- Conquest: Ocron, a mad queen who rules a wasteland with an iron fist.
- Contagion (2011): The titular contagion itself, which causes a global pandemic, is the ultimate source of all the conflict in the movie (the conflict that exists between humans, as opposed to between humans and the disease, is still indirectly caused by the disease).
- The Conqueror: Kumlek, the chief of the Tartars, sworn enemy of the Mongols, Who's responsible for killing Temujin's father.
- Copycat: Peter Foley, the Serial Killer targeting Dr. Helen Hudson so he can become a legend.
- Cosmos: War of the Planets: The computer that's controlling the aliens' world and plans to spread its influence across the galaxy.
- The Cottage: The unnamed Ax-Crazy farmer who stalks the farm the protagonists are hiding in.
- The Counselor: Malkina, who set the whole plot in motion by stealing the drug shipment and framing the Counselor for it.
- The Cowboys: "Long Hair" Asa Watts, the leader of the gang of rustlers who follow and harrass the employees of Double O Ranch.
- Crazed: Damien Logan, the leader of a sex trafficking operation who kidnapped Pierce's wife and aims to take over Harbor City.
- Creature with the Atom Brain: Frank Buchanan, the gangster controlling the zombies.
- Criminally Insane: Ethel Janowski, a madwoman who kills anybody who gets between her and food.
- Crimson Peak has Lady Lucille Sharpe, who wants to kill Edith so she can have Thomas all for herself.
- Cronos: Dieter de la Guarda, a dying man pursuing the Cronos Device for its power.
- The Crow: Top Dollar, who is not only responsible for ordering the attack that led to the deaths of Eric Draven and Shelly Webster, but came up with the debauched chaos of Devil's Night in the first place.
- The Crush: Adrian Forrester, Nick Eliot's obsessed stalker who's willing to ruin his life to be with him.
- Cry Wilderness: Morgan Hicks, who wants to hunt down and kill Bigfoot.
- C.S.A.: The Confederate States of America: Each John Ambrose Fauntroy, as they head a family dynasty that's considered "American royalty" and are responsible for all the political and cultural direction undertaken by the Confederacy. For instance, it was the influence of the first John Ambrose Fauntroy that resulted in the North embracing slavery.
- The Count of Monte Cristo: Fernand Mondego, who framed Edmond for treason in order to persue his fiancée Mercedes.
- Cube: Quentin, the most active threat to the group's survival who picks the members off one by one.
- Cube Zero: Jax, the evil organization's field man in charge of hunting down the escaped human lab rats.
- Cure: Kunihiko Mamiya, a hypnotist who makes other people commit incredibly brutal murders.
- The Curse of El Charro: El Charro, the undead land barron killing everybody.
- Curse of Pirate Death: Captain Abraham "Pirate Death" LaVoy, the ghost haunting Pirate's Point who wil murder anyone who attempts to take his treasure.
- Cy Warrior: Mr. Cooper, head of the Government Conspiracy chasing CB 3.
- Cyborg Cop: Professor Joachim Kessel, the drug baron who made Phillip a cyborg.
- Cyborg Soldier: Dr. Simon Hart, ISAAC's creator who is leading the effort to recapture him.
D
- Daimajin: Lord Odate Samanosuke, who took over the village and enslaved its people.
- The Dark (1979): The Mangler, an alien from outer space that's killing random people throughout Los Angeles.
- The Dark and the Wicked: The devil, who terrorizes a family on an isolated farmstead with the aims of driving them to suicide.
- Dark Angel: The Ascent: Mayor Wharton, the Corrupt Politician who makes the setting a Wretched Hive.
- Dark Asylum: Luther Wells, the killer terrorizing the asylum.
- Dark City (1998): Mr. Book, the leader of the Strangers, who kidnapped the humans and trapped them in the city for research.
- Darkman: Louis Strack Jr., who's willing to do anything to make his city development a reality.
- Darkman II: The Return of Durant: Robert G. Durant, who from being under Strack’s employ to seeking revenge against Darkman himself.
- Dark Night of the Scarecrow: Otis Hazelrigg, who led the party that killed Bubba for a crime he didn't commit and spends the film trying to cover up his crime.
- Dark Prince: The True Story of Dracula: Sultan Mohamed II, The Emperor subjugating Romania.
- Daughters of Darkness (1971): Elizabeth Báthory, the vampire killing virgins in order to remain eternally young and beautiful, and wants to make protagonist Valerie her next victim.
- Dead and Deader: Dr. Scott, a scientist seeking to sell the zombie infection for his own profit.
- Dead Before Dawn: The Ash Demon, a dark force turning a small town into zombie demons.
- Dead Heat: Arthur P. Laudermilk, a wealthy man having zombies commit robberies in order to perfect a resurrection machine.
- The Dead Lands: Wirepa, whose glory driven attack on Hongi's tribe being what kicks off the plot.
- The Dead One: Tezcatlipoca, the Aztec god who who forces a resurrected Diego to bring him sacrifices.
- Dead Silence: Mary Shaw, whose vengeful spirit aims to wipe out all of the family bloodlines in Raven's Fair.
- Dead Snow and Dead Snow: Red vs. Dead: Herzog, the leader of the zombies.
- Dead Hooker in a Trunk: The killer who has been murdering sex workers, including the titular hooker.
- The Dead Zone: Greg Stillson, who Johnny must stop from starting a nuclear apocalypse.
- Death on Demand: Sean McIntyre, an insane mountaineer who killed his family and then himself, then was summoned Back from the Dead in the middle of a livestream decades later.
- Death Race 2000: Mr. President, the dictator who organized the bloodsport race.
- Death Race: Warden Claire Hennessey, the ruthless prison warden who hosts the Death Race.
- Death Rides a Horse: Mr. Walcott, the leader of the gang who killed Bill's parents.
- Death Screams: Casey, who kills teenagers who have sex under a misguided sense of morality.
- Death Stop Holocaust: The Main Man, the leader of the gang of masked killers.
- Death Warrant: Chistian "The Sandman" Naylor, who's sent to the prison Burke's undercover at to kill him and Tom Vogler, who masterminds the prison's organ harvesting operation in an attempt to find organs for his dying wife.
- Death Wish series:
- Death Wish II: Nirvana, the leader of the gang that Kersey is after.
- Death Wish 3: Manny Fraker, the gang leader terrorizing the city.
- Death Wish 4: The Crackdown: Nathan White, a drug dealer who seeks to control to city's drug and manipulates Kersey into taking out his competition.
- Death Wish V: The Face of Death: Tommy O'Shea, a mobster who gunned down Kersey's girlfriend and kidnaps her daughter.
- Death Wish (2018): Knox is the leader of the thugs who murdered Paul Kersey's wife in a home invasion.
- Deathdream: Andy Brooks, a resurrected soldier draining people's blood.
- Deathgasm: Aeloth the Blind, a demon king set upon a small town by a mysterious hymn.
- Deep Blue Sea: The Mako Sharks who flood the facility and terrorize the scientists who experimented on them.
- Deep Red: Martha, who killed a psychic for noticing her madness, and is stalking the protagonist for witnessing it.
- The Defiant Ones: Sheriff Max Muller and Mack, who lead the pursuit to catch Joker and Noah.
- Deliverance: The Mountain Man and the Toothless Man, who attempt to hunt down and kill the leads while in the woods.
- The Delta Force: Captain Abdul Rafai, the head of the terrorist organization responsible for the plane hijacking.
- Delta Force 2: The Colombian Connection: Ramon Cota, a drug lord pushing cocaine into the US.
- The Demolitionist: "Mad Dog" Burn, a psychopathic criminal plotting to assassinate the mayor.
- Demolition Man: Simon Phoenix, an anarchistic terrorist let loose on a pacifist future.
- Demon Hunter (2005): Asmodeus, the Demon of Lust, who wants to father an army of half-demons to conquer the world.
- Demon Hunter (2016): Escharin Falstaff, the Evil Sorceror who set Barker on her path of vengeance and now plots to claim her soul.
- Demons: The Man in Black, the leader of the demons who trapped everybody in the theatre in the first place.
- The Demonologist: Abatu, one of the Four Horsemen of the Apocalypse, who leads a cult in trying to summon the others to Earth.
- The Departed: Francis "Frank" Constello, a ruthless mobster who molded Colin Sullivan into his personal informant and uses him to infiltrate the Massachusetts State Police.
- Department Q: The Keeper of Lost Causes: Lars Jensen, Merete's kidnapper who has been torturing her for the past five years.
- The Descent: The Crawlers, who spend the film hunting down the lead characters after they get trapped in their cave.
- Devil: The Devil is the one who traps the sinful passengers in the elevator to pick them off one-by-one.
- The Devil Bat: Dr. Paul Carruthers, a Mad Scientist setting mutant bats on the men who got rich off his cosmetic formula.
- The Devil's Advocate: John Milton, who uses his position to equit as many violent criminals as possible and ultimately wants to manipulate Kevin and his step-sister into birthing the Anti-Christ.
- The Devil's Backbone has Jacinto, who wants to take the treasure for himself, even if it means he has to kill for it.
- Dick Tracy: A Big Bad Ensemble of Big Boy Caprice and The Blank/Breathless Mahoney, both of whom are fighting for control over the city.
- The Dictator: Tamir, who attempts to have Aladeen killed and have a constitution signed that'll allow him to Wadaya's oil and build weapons of mass destruction.
- Die Hard:
- Die Hard: Hans Gruber, mastermind of the attack on Nakatomi Plaza.
- Die Hard 2: Colonel Stuart, who plots to rescue General Ramon Esperanza and holds Dulles Airport hostage.
- Die Hard with a Vengeance: Simon Gruber, who seeks to seize the Federal Reserve and humiliate John McClane for killing his brother Hans.
- Live Free or Die Hard: Thomas Gabriel, an ex-NSA analyst who plans to steal money from every citizen in the US after the NSA destroyed his reputation.
- A Good Day to Die Hard: Yuri Komarov, who plots to start World War III by stealing weapons-grade uranium from Chernobyl and selling it to the highest bidder.
- Dino Saur Hotel: The Games Master, the guy who set up the game and invites people to take part in it, broadcasting their life-or-death survival experiences for like-minded individuals to enjoy.
- Dirty Harry: The Scorpio Killer, a serial killer who terrorizes San Francisco.
- Magnum Force: Lt. Neil Briggs, the leader of a group of renegade cops who specialize in Police Brutality.
- The Enforcer: Bobby Maxwell, the leader of a group of terrorists who plot to kidnap the Mayor of San Francisco.
- Sudden Impact: Mick, the leader of a gang of rapists who raped Jennifer and her sister.
- The Dead Pool: Harlan Rook, a deranged fan of Peter Swan's movies who is responsible for the Dead Pool murders.
- Die You Zombie Bastards!: Baron Fucklove Mummyhead von Nefarious, the zombie-creating megalomaniac who kidnapped Toole's wife.
- District 9: Piet Smit, the head of the MNU and the source of the aliens' oppression, with Koobus Venter as The Heavy.
- Disturbia: Robert Turner, the killer Kale desperately tries to expose, who later attempts to kill everyone he holds dear in response.
- Divergent:
- Divergent: Jeanine Matthews, the leader of Eurdite who orders the attack on Abnegation.
- The Divergent Series: Insurgent: Jeanine Matthews again, who continues her hunt for the Divergent.
- The Divergent Series: Allegiant: David, the head of the Bureau who wants to return humanity to its natural state by creating geneically pure children, at the cost of taking free will away from countless people.
- Django: Major Jackson, local leader of The Klan who's vying for control of the town.
- Django Unchained: Calvin J. Candie, the head of the Candieland plantation, although his house servant Stephen is the actual brains of the operation and becomes the main threat after Candie dies.
- Doctor Blood's Coffin: Dr. Peter Blood, a Mad Scientist who wants to transfer hearts from the undeserving to the deserving.
- DodgeBall: A True Underdog Story: White Goodman, Peter's business rival who sets-up Average Joe's to get torn down and is the primary obstacle preventing him and his team from winning the prize money that could save it.
- Doll Factory has Yegor, the original owner of the titular doll factory who now commands an army of killer dolls. He wishes to collect enough human souls to become all-powerful.
- Doll from Hell: The unnamed leader of a gang of Japanese Delinquents who murder a girl while hiding from Yakuza they stole money from.
- Dollars Trilogy:
- A Fistful of Dollars: Don Miguel Rojo is the leader of the Rojo gang that controls San Miguel, but his brother Ramon is the main threat.
- For a Few Dollars More: El Indio. A psychopathic Bandito whose $10,000 bounty attracts Manco's attention and whose crimes make him the target of Colonel Douglas Mortimer, who wants revenge on Indio for raping Mortimer's sister and causing her suicide.
- The Good, the Bad and the Ugly: Angel Eyes, a cold-hearted Professional Killer who is Blondie and Tuco's primary antagonist in a search for gold.
- Dogma: Azrael, a Fallen Angel who manipulated Bartleby and Loki into attempting reentry into Heaven, which would overrule the word of God and unmake existence.
- Donovan's Reef: Marquis Andre de Lage, who attempts to woo Amelia in order to gain her family's riches.
- Don't Go in the Woods: The unnamed maniac killing anybody entering his woods.
- Don't Kill It: An unnamed demon on a body-jumping killing spree.
- Don't Open Till Christmas: Giles Harrison, who kills men dressed as Santa to give his brother an interesting case.
- Don't Torture a Duckling: Don Alberto Avallone, a religious fanatic killing boys so they never develop sexuality.
- Doom: Dr. Carnack, who is responsible for the experiments that caused the outbreak in the first place.
- Double Indemnity: Phyllis Dietrichson, who convinces Walter Neff to help kill her husband and collect the insurance money. Afterwards, she plans on killing Neff and her stepdaughter to ensure the crime won't be exposed.
- Double Jeopardy: Nick Parsons, who frames Libby for his murder so he can be with another woman and plans on killing her once she's on parole.
- Downfall: Adolf Hitler, as the instigator of World War II and the Holocaust. While his power is all but gone, his influence over the German people is unquestionable, with many Nazis committing suicide for their Führer or killing anyone who dares disobey his orders.
- Dr. Cyclops: Dr. Alexander Thorkel, a Mad Scientist seeking to perfect shrinking technology.
- ''Dr. Heckyl and Mr. Hype: Mr Hype is the embodiment of evil.
- Dracula Untold: Sultan Mehmet, the leader of the forces trying to conquer Wallachia.
- Drag Me to Hell: The Lamia, the demon sent to terrorize Alison before dragging her to Hell.
- Dragonheart: King Einon, a tyrant who uses his seeming immortality to commit whatever atrocities he pleases.
- Dread: Quaid, a madman willing to torture people to understand the nature of fear.
- Dredd: Madeline "Ma-Ma" Madrigal, a drug baroness who controls a giant skyscraper apartment.
- The Driller Killer: Reno Miller, a frustrated artist who becomes a Serial Killer.
- Drive Angry: Jonah King, who murders Milton's daughter and kidnaps his granddaughter with the intent of sacrificing her.
- Drive-In Massacre: The unnamed killer stalking the drive-in.
- Duck Soup: Trentino, Sylvania's ambassador who tries to start a war with Freedonia.
- Duel: The Truck Driver chasing down David.
- The Duellists has Gabriel Féraud.
- Dune (2021): Baron Vladimir Harkonnen is the mastermind behind the ambush and elimination of House Atriedes.
- Dune: Part Two: The ultimate puppet master behind the Baron and the Emperor is Ghias Helen Mohiam, the Bene Gesseritt Reverend Mother who manipulates the bloodlines and the actions of both films by controlling both villains and revealing the Baron to be a Big Bad Wannabe
- The Dungeonmaster: Mestema, the sorcerer forcing Paul into the challenges..
E
- Eagle Eye: Aria who is actually a computer, who manipulates Jerry and Rachel in aiding her plan to kill the Preident and his staff.
- Easter Bunny, Kill! Kill!: Remington Rashkor, a thug whose abuse of a young boy starts the killing.
- Eaten Alive! (1976): Judd, a Serial Killer feeding people to his pet crocodile.
- Edge of Tomorrow: The Omega Mimic, the leader of the mimics.
- Edward Scissorhands: Jim, Kim's scummy boyfriend who grows increasingly violent in his jealousy.
- Elfie Hopkins: Cannibal Hunter: Mr. Gammon, patriarch of a Cannibal Clan.
- Elysium: Defence Secretary Jessica Delacourt oppresses the people of Earth in the name of the elitist Elysium and when Max ends up stealing her plans to take over the Space Station, she begins targeting him directly. Her position gets usurped by her unstable henchmen Kruger, who had already been a far more active threat than she, when he kills her and takes over Elysium himself.
- Empire of the Sun: Sergeant Nagata, the head of the Japanese interment camp that imprisons Jim.
- End of Days: Satan, who intends to conceive The Antichrist on New Year's Eve.
- Enemy Mine: Stubbs, an illegal mine owner who enslaves aliens.
- Enola Holmes: The Dowager of Tewkesbury is an Evil Reactionary who orders the death of her grandson the Viscount before he can vote on a reform bill in the House of Lords.
- Enola Holmes 2: Mira Troy - AKA Moriarty. She attempted to profit off her employer’s corrupt deal with a matchmaking factory to increase profits at the expense of their employers. When Sarah Chapman discovers evidence of this, she hires Superintendent Grail to retrieve the evidence at any cost, including murder. All the while, she taunts Sherlock through a cypher hidden in bank transfers.
- The Equalizer: Nicolai Itchenko, the overseer of the Russian mob's human trafficking ring, with Vladimir Pushkin as the Greater-Scope Villain.
- The Equalizer 2: Dave York, the mastermind behind Susan's murder.
- The Equalizer 3: Vincent Quaranta, who wants to tear down the Sicilian neighborhood so he can build resort hotels and casinos over it.
- Equilibrium: Vice-Counsel DuPont, the true leader of the Libria police state.
- Erin Brockovich: The Pacific Gas and Electric Company, who Julia takes to court for dumping toxic waste into the water supply.
- Escape from Alcatraz: The Warden making life as miserable as possible for the prisoners of Alcatraz.
- Escape from New York: The Duke, who has taken control of the New York City prison and inholding the President hostage.
- Escape from L.A. has Cuervo Jones, who has united Latin America under the Shining Path to invade the United States .
- Event Horizon: The Event Horizon, with the insane Dr. William Weir as the final threat and embodiment of the ship's evil. The Event Horizon itself that wants to drag more people, if not all of humanity, into Hell beyond the stars.
- The Evil: Satan, the evil force trapped in the house.
- Evil Dead: The Evil Force controlling the Deadites.
- Evil Laugh: Sadie Burns, who is killing everybody to prevent the orphanage where he son committed mass murder-suicide from reopening.
- Excalibur; Morgana le Fey, Arthur's half-sister who uses black magic and feminine wiles to destroy Camelot.
- Executive Decision: Nagi Hassan, a terrorist leader who intends on setting off a nerve gas bomb in Washington D.C..
- Exodus: Gods and Kings has Pharaoh Ramses II, who's responsible for the opression of the Hebrew people.
- The Exorcist: Pazuzu, the ancient demon posesing Regan.
- The Expendables: James Munroe, a rogue CIA agent running General Gaza's drug smuggling business.
- The Expendables 2: Jean Vilain, a mercenary and arms dealer who intends to sell lost plutonium to the highest bidder.
- The Expendables 3: Conrad Stonebanks, an arms dealer out to end the Expendables.
- Expend4bles: Ocelot, whose true identity is Marsh, a rogue CIA agent turned terrorist leader who is planning on starting World War III by smuggling nuclear weapons, with Suarto Rahmat as The Heavy.
- The Exterminators of the Year 3000: Crazy Bull, head of a cult of water-hoarding Desert Bandits.
- Eyes of a Stranger: Stanley Herbert, the "Phone Freak" serial rapist/killer.
- Eyes Without a Face: Dr. Génessier, who has multiple women kidnapped in order to cut off their facial skin and transplant it onto his disfigured daughter's face.
F
- The Fan: Gil Renard, an obsessed fan of Bobby Rayburn who goes to dangerous lengths to gain his favor before deciding to kidnap his son after learning that Bobby doesn't appreciate his fans.
- Fantastic Voyage: The Mole Dr. Michaels, the one sabotaging the team's mission to save Jan Benes.
- Fargo: While Jerry Lundegaard masterminds the plot to have his wife kidnapped in order to get ransom money, the criminals he hires, Carl Showlater and Gaear Grimsrud, are the more pressing threats that Marge has to deal with.
- The Fast and the Furious: The Myth Arc has Cipher, The Woman Behind the Man to Owen Shaw and Mose Jakande in the sixth and seventh films respectively, and later a direct antagonist for Dom in the eighth and ninth films.
- The Fast and the Furious (2001): Johnny Tran, Dom's bitter rival in Race Wars out to get him.
- 2 Fast 2 Furious: Carter Verone, the ruthless drug kingpin whose operation Brian and Roman must undermine in order to get their criminal records cleared.
- The Fast and the Furious: Tokyo Drift: Takashi, whose jealousy and Yakuza connections drives the conflict.
- Fast & Furious: Arturo Braga, the head of the drug running operation.
- Fast Five: Hernán Reyes, the drug lord who's the target of the team's heist.
- Fast & Furious 6: Owen Shaw, the leader of the mercenary operation that the team are recruited to stop.
- Furious 7: Deckard Shaw, who teams-up with and Mose Jakande, to destroy Dom and his team as revenge for putting his brother in a coma.
- The Fate of the Furious: Cipher, a cyberterrorist who blackmails Dom into betraying his team and stealing nuclear codes for her.
- Hobbs & Shaw: Brixton Lore, the cybernetic soldier after the deadly super-virus.
- F9: Otto, the mastermind behind the plan to steal and activate Project Ares until Cipher takes over in the climax.
- Fast X: Dante Reyes, the son of the late Hernán Reyes who is seeking revenge on Dom and his family over the death of his father.
- Falling Down: William "Bill" Foster, an unstable veteran who goes on a rampage in Los Angeles.
- Fatal Attraction: Alex Forrest, who stalks and torments Dan and his family out of an obsession with him after they had an affair.
- Fatman: Billy Wenan hires Professional Killer "Skinny Man" to kill Santa Claus over receiving a lump of coal for Christmas... which is Billy's own fault thanks to being a Sore Loser at the science fair.
- Faust: Mephisto, who tempts Faust into giving up his soul on a bet with an angel.
- Faust: Love of the Damned: M, the demonic being trying to bring Hell on Earth.
- Fear (1996): David McCall, Nicole's abusive and possessive ex-boyfriend who holds her family hostage after she breaks up with him.
- Feardot Com: "The Doctor" Alistair Platt, a Serial Killer who's been kidnapping women and streaming himself torturing them on the titular website.
- A Few Good Men: Colonel Nathan R. Jessup. Dawson and Downey acted on his illegal orders and Kaffee and his legal team have to thwart his attempts to evade justice and throw them under the bus.
- The Fifth Element: The Evil, a sapient star-like entity bent on the destruction of all life, with Jean-Baptiste Emmanuel Zorg as The Heavy.
- Final Destination: Death, who spends each movie killing those who cheated him through brutal and elaborate means.* Final Exam: The unnamed killer stalking the college.
- The Final Girls: Billy Murphy, the killer in the Slasher Movie the protagonists are trapped in.
- Fire Twister: Garber, a Corrupt Corporate Executive who was responsible for creating the titular fire twister after making a deal with the CIA.
- Fire with Fire: David Hagan, a neo-Nazi gang leader pursuing a witness to his crimes.
- First Knight: Malagant, who seeks to overthrow King Arthur and become Camelot's ruler.
- Five Deadly Venoms: Zhang Yiaotian the Centipede and Gao Ji the Scorpion, renegade students of the Venom Clan who seek to steal its accumulated wealth.
- Fist of Legend: General Fujita, the Imperial Japanese officer who had Chen Zhen's master killed.
- Flash Gordon: Ming the Merciless, the tyrannical overlord out to destroy Earth.
- The Flesh and Blood Show: Sir Arnold Gates, the identity of the killer targeting the theatre actors.
- The Flesh Eaters: Professor Peter Bartell, a Mad Scientist who seeks to sell flesh-eating microbes for profit.
- Flesh for the Beast: John Stoker, a seemingly-kindly billionaire who is trying to control the succubi.
- A Fool There Was: The Vampire, who seduces John Schuyler and ruins his life.
- Footloose: Reverend Shaw Moore, the one behind the outlawing of dancing and rock music, a measure that protagonist Ren Mc Cormack opposes.
- The Forbidden Kingdom: The Jade Warlord, the tyrannical ruler of the Chinese kigndom.
- The Four Skulls of Jonathan Drake: Dr. Emil Zurich, a Reverend Zombie tasked by voodoo gods with killing the descendants of the man who slaughtered their tribe.
- Frankenhooker: Jeffrey Franken, a Mad Scientist butchering prostitutes to make a new body for his dead wife.
- Frankenhooker: Jeffrey Franken, a Mad Scientist butchering prostitutes to make a new body for his dead wife.
- Frankenstein's Army: Dr. Viktor Frankenstein, grandson of the more famous doctor, who has been experimenting to make automatons for the Nazis but secretly has his own agenda.
- Freaked: Dick Brian, secret funder of the mutation experiments.
- Freaks: Cleopatra and Hercules, who conspire to kill Hans and take his inheritance.
- Freaky: The Blissfield Butcher is a Serial Killer living in the town of Blissfield Valley with a decades-long rap sheet who winds up switching bodies with one of his attempted victims.
- Freeway: Bob Wolverton, a Serial Killer who picks Vanessa up early in the film and tries to ruin her life when she injures him in self-defense.
- Free Guy: Antwan, the head of Soonami Games who wants to make his Free City franchise a success and will do anything to make it a success even through illegal means.
- The French Connection: Alain Charnier, the drug dealer Popeye Doyle is tracking.
- Popeye Doyle: Auram Bardas, a.k.a. the Weasel, a terrorist for hire hunted by Mossad.
- Frenzy: Bob Rusk, a serial killer who frames Richard for the former's own murders, and the one responsible for killing numerous women.
- Frequency: Jack Shepard, the Nightengale Killer murdering nurses and stealing their jewlery who frames Frank for his crimes.
- Friday the 13th: Jason Voorhees. Once a deformed child who supposedly drowned at Camp Crystal Lake, he reemerges after his mother's death in the first film and causes rampant death and mayhem for anyone unlucky enough to venture within the camp's vicinity.
- Friday the 13th (1980): Pamela Voorhees, Jason's mother who committed two murders after Jason supposedly drowned and is intent on making sure the camp doesn't reopen.
- Friday the 13th Part V: A New Beginning: Roy Burns, who went on a rampage when his son is accidentally killed.
- Fright Night (1985): Jerry Dandrige, a vampire who lives next to the protagonist and seeks to feed on people around their neighborhood.
- Fright Night Part 2: Regina Dandrige, who's out to avenge her brother.
- The Frighteners: The Grim Reaper actually Johnny Barlett, who comes back from Hell to claim the largest body count of any serial killer yet.
- Frightmare (1983): Conrad Radzoff, the undead actor killing everyone.
- From Beyond: Dr. Edward Pretorius, who is mutated by the creatures from beyond and immediately decides to start tormenting humanity.
- From Dusk Till Dawn: Santánico Pandemonium, the leader of the vampires that invade the Titty Twister and attack our heroes.
- Frontier(s): Karl von Gleiser Sr., a former Nazi who runs a hotel with his Cannibal Clan children.
- Frostbite: The Shape, AKA Dr. Gerhard Beckert, a Nazi vampire trying to create human-vampire hybrids.
- Frostbiter: Wrath of the Wendigo: The Wendigo, who has been awoken from its prison and is on a rampage.
- The Fugitive: Dr. Charles Nichols, the one who arranged Helen's murder and had Kimble framed for it.
- Full Metal Jacket: In the first half, Gunnery Sergeant Hartman who trains the recruits to become Marines. In the second half, the VC sniper that fires on the Lusthog Squad when they become lost in the city of Hue.
- Funny Man: Callum Chance, who summons the Funny Man to kill Max Taylor's family after he lost his home to fair and square.
- Future Force: Jason Adams, the head of C.O.P.S. who puts a bounty on John's head after trying to expose the corruption within the organization.
G
- The Galaxy Invader: Joe Montague, who is trying to kill an innocent alien for profit and horribly abuses his family.
- Galaxy Quest: General Roth'h'ar Sarris, the leader of a campaign to hunt the Thermians to extinction.
- Gallowwalkers: Kansa, an undead Outlaw seeking to resurrect his son.
- Gamer: Ken Castle, the billionaire inventor and organizer of the virtual Deadly Game.
- Gangs of New York has Bill "the Butcher" Cutting, a violent nativist who Amsterdam seeks revenge against for killing his father.
- Gangster Squad: Mickey Cohen, a psychopathic gangster imposing a stranglehold on Los Angeles through illegal business and prostitution. The titular squad is formed to counter him.
- Garfield: Happy Chapman, who abducts Odie to make him star in his show and become popular, while doing everything to make sure Garfield doesn't get him back.
- Garfield: A Tale of Two Kitties: Lord Dargis, who masterminds the plot to get rid of Prince.
- Get Out (2017): Roman Armitage, founder of a body-stealing racism cult.
- Getaway: The Voice, a mysterious figure who kidnaps Brent's wife and forces him to do his bidding.
- Ghost (1990): Carl Bruner, who arranged Sam's mugging that resulted in his death.
- The Ghost Dance: Nahalla, the spirit of a Native American cult leader killing the excavation team that found his body.
- Ghost in the Machine: Karl Hochman, who uses his new digital form and electrical powers to go on a killing spree.
- Ghost in the Shell (2017): Cutter, who creates and manipulates the cyborgs to use as weapons and plans to kill the Major when she finds out too much, putting them at odds.
- Ghost Note: Eugene Burns, a blues musician who created music that causes anyone who hears it to kill themself, and whos guitar can influence anyone who has touched it.
- Ghost Ship: The Ferriman is responsible for all the previous deaths on the Graza, the murder of subsequent salvage crews, and is working for Hell to collect souls.
- Ghostbusters:
- Ghostbusters (1984): Gozer the Gozerian, an Ancient Evil that travels dimensions to destroy them.
- Ghostbusters II has Vigo the Carpathian. He's responsible for the Mood Slime flooding New York, and plans on using Dana's baby to be reincarnated into the physical world.
- Ghostbusters (2016) has Rowan North. He felt his genius was feeling unappreciated and decided to get back at the world by triggering an apocalyptic ghost invasion in New York City, even becoming a darngerous ghost himself.
- Ghostbusters: Afterlife has Gozer the Gozerian once again. Its arrival in 1984 was one of many prophesied disasters, and its next arrival in 2021 is the reason why Egon left his family and team behind as he became dedicated to stopping it for good.
- Ghoulies: [[Evil Sorcerer Malcolm Graves.
- G.I. Jane: Senator Lillian DeHaven, who frames Jordan for being a lesbian in order to avoid military bases closing in her home state of Texas..
- GI Joe The Rise Of Cobra: Destro, who creates nanite warheads with the intent to destroy several cities until The Doctor/Cobra Commander takes over.
- G.I. Joe: Retaliation: Cobra Commander, this time using Project Zeus to force the world to submit to Cobra, with Zartan as the Dragon-in-Chief.
- The Giant Claw: The antimatter bird terrorizing the city.
- Giant Monster Gamera: Gamera, who emerges from the Arctic to terrorize the world.
- The Gingerdead Man: Millard Findlemeyer, an executed Serial Killer whose vengeful spirit has possessed a gingerbread man.
- The Girl Next Door: Ruth Chandler, a sadistic woman leading her sons in torturingher niece.
- Gladiator: Commodus, the new emperor of the Roman Empire who Maximus seeks revenge against for killing his family.
- The Godfather:
- Don Emilio Barzini in Part I, the man who ostensibly keeps the Five Families together, but is secretly plotting to topple them all.
- Hyman Roth in Part II is the man trying to destroy the Corleones as revenge for the assassination of Hyman's protege Moe Greene at the end of Part I. In the past story, Don Francisco Ciccio is the main villain of Vito's story as the man who had Vito's family murdered because of his ego, forcing him to flee to America.
- Don Osvaldo Altobello and Don Licio Lucchesi in Part III, two crime bosses who plot to have Michael assassinated to prevent the Corleones from gaining control over the Vatican Bank's share of Immobiliare, a company run by Lucchesi. Their ally, Joey Zasa, attempts to gain more power in the Mafia by aiding Altobello and Lucchesi in their scheme to assassinate Michael, only for Zasa to be killed by Vincent partway through the movie.
- Goke, Body Snatcher from Hell: The Gokemidoro, a body-snatching alien out to exterminate the human race.
- The Golden Child: Sardo Numpsa, who wishes to kill the titular child to bring about the rule of evil on Earth.
- Gone Baby Gone has Captain Jack Doyle, the one behind Amanda's kidnapping.
- The Good Son: Henry Evans, a sociopathic boy terrorizing his cousin Mark before attempting to kill his family so he can continue to kill without consequence.
- The Goonies: Mama Fratelli. As the leader of the criminal gang out to find the treasure as well as evade justice for their previous crimes, to the extent of being willing to kill the Goonies, she's the most immediate looming threat for most of the film.
- Goosebumps (2015): Slappy, who unleashes all the other monsters from their books and then leads them against Stine and the children.
- The Gore Gore Girls: Marlene, the killer targeting local strippers.
- Gory Gory Hallelujah: Preacher John, who tries to awaken a Zombie Apocalypse.
- Goth (2003): Goth, a madwoman who believes that true goth culture is indulging in as much hedonistic rape and murder as possible.
- Graduation Day: Kevin Badger, who is slowly picking off the track team he blames for his girlfriend's death.
- Grabbers: The male grabber leads the alien colony invading a small Irish village.
- Grave of the Vampire: Charles Croydon, the vampire who raped the hero's mom and is responsible for his half-undead curse.
- The Gray Man (2022): Lloyd Hansen, an Ax-Crazy CIA agent trying to bring down Gentry and Miranda for uncovering agency secrets.
- The Green Berets: General Phan Son Ti, a North Vietnamese general the Green Berets must capture in order to end the Vietnam War.
- In Green Room Darcy, the sadistic, neo-Nazi owner of the club, imprisons the Ain't Rights band when they witness a murder by one of his goons and attempts to kill them to cover up the crime.
- Gut-Pile: The unnamed murder victim, who goes on a ruthless rampage to avenge his accidental slaying.
- Gutterballs: Steve, leader of the gang rape that started the killings.
H
- Hack-O-Lantern: Grandpa Drindle, a Satanic cult leader manipulating his son into becoming his successor.
- Hail, Caesar! has Burt Gurney, the one responsible for Eddie Mannix's kidnapping.
- Hairspray: Velma Von Tussle, who fights to keep the Corny Collins show segregated.
- Hallowed Ground: Jonas Hathaway, a fanatical Sinister Minister plotting to return from the dead.
- Halloween: Michael Myers, a Serial Killer who escapes from a sanitarium and returns to his hometown to stalk and murder the populace.
- Halloween III: Season of the Witch: Conal Cochran, a Corrupt Corporate Executive who plans to kill thousands of children via rigged Halloween masks.
- Halloween Night: Chris Vale, a traumatized man killing everybody in his childhood home.
- Hancock: Kenneth "Red" Parker Jr., who wants revenge on Hancock for cutting off his hand.
- The Hand: Jon Lansdale's hand, who goes around murdering those who anger him.
- The Hand That Rocks the Cradle: Peyton Mott.
- Hands of the Ripper: Anna, Jack the Ripper's daughter who has inherited his madness.
- Hansel & Gretel: Warriors of Witchcraft: The Great Witch of the Woods, the powerful spirit the Circle sacrifices people to.
- Hansel & Gretel: Witch Hunters: Muriel the Grand Black Witch, who seeks to sacrifice a bunch of children to make all evil witches immune to fire.
- Hard Candy: Jeff Kohlver, a Serial Rapist of teenage girls.
- Harakiri: Saitö Kaguya, the corrupt head of a samurai clan.
- Hatchet: Victor Crowley, an Ax-Crazy spirit terrorizing the New Orleans swamps.
- The Hateful Eight has Jody Domergue, the leader of the outlaws and the mastermind behind the plot to free Daisy.
- HauntedWeen: Eddie Burber, a psycho killing frat bros in his childhood home.
- Havenhurst: Eleanore Mudgett is the landlord of an apartment building where people with various addictions and vices can stay to recover. If they fall back into their problems, however, Eleanore has them dropped into the basement, where they're sadistically tortured to death by her sons.
- Hawk the Slayer: Voltan, Hawk's brother, who killed their father for the Mindstone and is now holding a bunch of nuns hostage to do the same.
- He Knows You're Alone: Ray Carlton, a Serial Killer of brides.
- Heat: Neil McCauley, a Gentleman Thief who Vincent Hanna seeks to stop.
- The Heat: Larkin, the drug lord. The plot is centered around the investigation into his activities and his retaliations against them.
- Heathers: Jason "J.D." Dean, a charismatic bad boy killing the popular kids.
- The Hebrew Hammer: Damien Claus, who has killed his father and taken over his job as Santa Claus to destroy Chanukah and Kwanzaa.
- Hellbenders: Surtr, a Destroyer Deity trying to kickstart the apocalypse.
- Hellbinders: Samael, the head demon of Legion, who seeks to unleash Hell on Earth.
- Hellboy (2004): Grigori Rasputin, who seeks to summon his dark gods to destroy the world.
- Hellraiser: Pinhead, leader of a demonic cult of pain and pleasure, is this for the franchise overall, although in most films he plays Greater-Scope Villain to another character.
- Hellraiser: Frank Cotton, a sadist who gets Julia Cotton to kill people to restore his body after having his flesh torn off by the Cenobites. Pinhead and his Cenobites lurk in the background and kill Frank at the end of the movie.
- Hellbound: Hellraiser II: A Big Bad Duumvirate of Julia Cotton and Dr. Phillip Channard in the first half, up until they solve the puzzle box and unleash Leviathan.
- Hellraiser III: Hell on Earth: Pinhead, after playing Greater-Scope Villain in the first and being Demoted to Dragon in the second, is the main antagonist of this film with his plans to unleash the titular "Hell on Earth".
- Hellraiser: Bloodline has Pinhead again. He spends the first half in a tenuous Big Bad Duumvirate with Angelique, but by the third act he's solidified himself as the dominant one and turned Angelique into a Cenobite.
- Hellraiser: Inferno has the Engineer, a gruesome Serial Killer who is really Joseph Thorne himself and exists as part of his Hell. Pinhead appears as the Greater-Scope Villain since he's the one facilitating Joseph's suffering, and holds the role for the next few films after it.
- Hellraiser: Hellseeker has Trevor, the supposed protagonist of the film, who was really cheating on Kirsty and plotting to kill her.
- Hellraiser: Deader has Winter Merchant, head of the Deader cult.
- Hellraiser: Hellworld has the Host, who organized the party where the protagonists are picked off by Cenobites.
- ''Hellraiser: Revelations" has Nico, who has Steve kills various people in order to bring him back from hell and later holds the latter's family hostage in order to try and escape from the Centobites
- Hellraiser: Judgement has the the Preceptor a Serial Killer who's murder's are based on the ten commandments. Detective Sean Carter is revealed to be him and is, much to Pinhead’s disgust, protected by Heaven and cannot be harmed by even the Cenobites.
- Hellraiser (2022) has Roland Voight, who plans to lure and trap the Cenobites by bringing more victims in order to summon the Leviathan to convince him to free him of the Liminal Configuration Box
- Hells Angels on Wheels: Buddy, leader of the local Hells Angels chapter.
- Henry: Portrait of a Serial Killer: Henry, who wanders around the country killing people for no reason.
- Hereditary: King Paimon, a demon tormenting a family so he can steal their son's body.
- High and Low: Ginjiro Takeuchi, a kidnapper of children.
- High Noon: Frank Miller, a gang leader who has been released from prison and is out for Marshal Will Kane's blood.
- The Hills Have Eyes and its 2006 remake have Papa Jupiter, patriarch of a Cannibal Clan stalking a desert.
- The Hitcher: John Ryder, a hitchhiker who kills those who pick him up.
- Hitler, Dead or Alive: Adolf Hitler, whom the gangsters we follow have been hired to assassinate.
- The Hitman's Bodyguard: Vladislav Dukhovich, the deposed dictator whose war crimes and trial drive the plot, as he tries to have the titular hitman killed before he testifies at his trial.
- The Hitman's Wife's Bodyguard: Aristotle Papadopoulos, a Greek nationalist intending to destroy Europe's infrastructure in retaliation for the EU crushing Greece's economy with sanctions, and Michael Bryce Sr., a former bodyguard and Bryce's stepfather who as Aristotle's head of security acts as The Dragon.
- Hobo With a Shotgun: The Drake, the Ax-Crazy crime boss terrorizing Hope Town.
- Hollywood Chainsaw Hookers: The Master, leader of a chainsaw-worshipping murder cult.
- Hook: Captain Hook, who kidnaps Peter's son in hopes of getting to fight him once again and settle the score.
- Horror of Dracula: Count Dracula, the vampire lord Van Helming is hunting down.
- The House tetralogy:
- The first film has Big Ben, the ghost of protagonist Roger's former military buddy in the Vietnam conflict, who wants revenge for being left behind by him.
- House II: The Second Story has Slim Reeser, the former friend of te protagonist's grandfather, who betrayed him in the past and was shot for it. He is now a vengeful ghost who is after the crystal skull in main character's possession.
- The Horror Show (aka House III) has Max Jenke, a ghost of a Serial Killer who returns to torment the police detective who caught him and send him to the electric chair.
- Burke in House IV, the sole human main villain of the series, who wants to drive the Cobb family from the house that's rightfully theirs, so that he can sell it and the land around it.
- House of 1000 Corpses: Dr. Satan, patriarch of the homicidal Firefly family.
- House of Usher: Roderick Usher, who is willing to do anything to end his family's evil legacy.
- House of Whipcord: Margaret Wakehurst, a Knight Templar who abducts "loose" women to forcibly rehabilitate.
- House on Haunted Hill (1959): Annabelle Loren, who organized the entire party to murder her husband.
- Housebound: Dennis, who committed the plot-driving murder.
- Howard the Duck: The Dark Overlord of the Universe, an Eldritch Abomination plotting to bring his brethren to Earth.
- The Howling: Eddie Quist, a werewolf Serial Killer who starts Karen's investigation into the werewolf compound.
- The Hudsucker Proxy has Sidney J. Mussburger, who hires Norville in the hopes that he'll cause the profits of Hudsucker Industries to plumet within six months, allowing him to buy the company for himself on the cheap.
- The Hunger: Miriam Blaylock, a narcissistic vampire seeking a new lover.
- Hush: An unnamed Serial Killer tormenting a deaf woman.
I
- I Come in Peace: Talec, an alien drug dealer who sells human spinal fluid.
- I Drink Your Blood: Horace Bones, the leader of the hippie cult terrorizing the town.
- I Eat Your Skin: Charles Bentley, who intends on using an army of zombies to Take Over the World.
- I, Frankenstein: Naberius, a demon prince who wishes to resurrect The Legions of Hell to destroy humanity.
- I Know What You Did Last Summer: Ben Willis, who hunts down the main cast after leaving him to die in a hit and run.
- I, Robot: VIKI, who leads a robot rebellion to Take Over the World.
- I Saw the Devil: Kyung-Chul Jang, who Kim Soo-hyun is set on killing after he murders his fiancée.
- I Sell the Dead: Samuel Murphy, the patriarch of a family of ruthless grave robbers.
- I Spit on Your Grave: Johnny, the leader of the gang of rapists who sexually assaulted Jennifer.
- I'll Kill You... I'll Bury You... I'll Spit on Your Grave Too!: Roger McFloyd, the one behind the string of murders.
- The Iceman: Roy Demeo, the mob boss who initially hired Kuklinski before opposing him by film's end.
- Idiocracy: The unnamed CEO of Brawndo, an energy drink company that is causing the collapse of the ecosystem by feeding the plants their product instead of water. However, unlike many Big bads, he isn't malicious, as like the rest of humanity in this setting, he's really, really stupid.
- Idle Hands: The unnamed evil force, which possesses lazy men's hands to kill for it.
- The Illusionist (2006): Prince Leopold, who intends to usurp his father by forcing Sophie to marry him, and tries to expose the magic tricks of the titular magician, Eisenheim, who wants to free Sophie from him.
- I'm Gonna Git You Sucka: Mr. Big is in charge of all crime in the city and he doesn't like people asking questions about him. When they do, he sends his thugs around to shut them up.
- Immortals: Hyperion, who murdered Theseus' mother and plans to unleash the race of the Titans from their prison in order to wipe out humanity.
- In the Line of Fire: Mitch Leary, a man determined to assassinate the US President.
- Indiana Jones:
- Rene Belloq and Colonel Herman Dietrich in Raiders of the Lost Ark, with the former directing most of the actual archaeology and actively antagonizing Indy and Marion and the latter officially leading the Nazi operation to bring the Ark to Adolf Hitler.
- Mola Ram in Indiana Jones and the Temple of Doom, the High Priest of the Thuggee Cult who seeks to conquer the world.
- Walter Donovan in Indiana Jones and the Last Crusade, who seeks the Holy Grail for himself and is willing to work with the Nazis to acquire it.
- Irina Spalko in Indiana Jones and the Kingdom of the Crystal Skull, who seeks the titular Crystal Skull in a quest for knowledge.
- Jürgen Voller in Indiana Jones and the Dial of Destiny, a former Nazi scientist recruited into NASA, seeking the Antikythera mechanism to plot a course back to 1939, where he will assassinate Hitler and seize control of the Third Reich for himself.
- Inglourious Basterds: Colonel Hans Landa, a Nazi colonel hunting the Basterds and Shosanna Dreyfus.
- The Innkeepers Madeline O'Malley, the ghost haunting the hotel.
- Innocent Blood: Sal "the Shark" Marcelli, a Mafia don who's been turned into a vampire.
- Internal Affairs: Dennis Peck.
- Interstellar: Dr. Hugh Mann, serves as the biggest obstacle to the Endurance crew’s mission to find a new home for humanity.
- The Invitation (2015): Dr. Joseph, a cult leader who believes the best solution to grief is murder-suicide.
- Ip Man: General Miura, the leader of the Japanese forces occupying Ip Man's village and the one who challenges him to a martial arts match.
- The Irishman has Tony Pro. He's Jimmy Hoffa's main rival and the one who orchestrated the conflict with him.
- Ironclad: King John, who seeks to bring England back under his rule after reluctantly signing the Magna Carta.
- Iron Eagle: Col. Akir Nakesh, the Ministry of Defense of an anonymous Middle Eastern country that has captured Ted Masters and is planning to execute him for trespassing.
- Aces: Iron Eagle III: Gustav Kleiss, an ex-Nazi war criminal who runs a drug cartel that has taken over a Peruvian village.
- Iron Eagle on the Attack: Brad Kettle, a rogue Air Force general planning on using chemical weapons onto Cuba.
- It Came from Beneath the Sea: The giant octopus terrorizing San Francisco.
- It! The Terror from Beyond Space: The Martian picking off the human astronauts.
- It's a Wonderful Life: Mr. Potter, the owner of the bank who seeks to bring Bedford Falls under his foot with his only opposition being George Bailey.
- It's My Party and I'll Die If I Want To: Jacob Burkitt, who killed his family and now haunts his house as a murderous ghost.
J
- The Jackal: The Jackal, hired by The Mafiya to assassinate the Director of the FBI in retaliation for the death of one of their own. His real target is actually the First Lady.
- Jack Frost (1997): Jack Frost, a Serial Killer turned into a snowman by a freak accident.
- Jack-O: Walter Machen, a ghostly Evil Sorcerer who sets a demon on the descendants of the man who executed him.
- Le Jaguar: Kumare, a ruthless South American gang leader who wants to steal lands belonging to an indigenous tribe in The Amazon Rainforest.
- Jason Bourne Series:
- The Bourne Identity: Alexander Conklin, head of Operation Treadstone and the one trying to have Bourne killed to cover up the program.
- The Bourne Supremacy: CIA Section Chief Ward Abbott, who spends the film trying to cover up his shady dealings with a Russian oil tycoon and who was also Conklin's superior in the previous film.
- The Bourne Ultimatum: Noah Vosen, the CIA official in charge of executing Operation Blackbriar. He's doing legwork for Ezra Kramer, but he's the one opposing Bourne throughout the movie.
- The Bourne Legacy: Eric Byer, the head of Operation Outcome and their associated research projects, who uses murderous means to cover them up.
- Jason Bourne: CIA Director Robert Dewey, the mastermind behind Iron Hand and the one targeting Bourne throughout the movie. He's also responsible for the events of the whole series, being behind Bourne's enlistment into Treadstone and his father's death.
- Jaws: Bruce, the giant man-eating shark terrorizing Amity Island.
- Jennifer's Body: Jennifer Check, a demonic cheerleader terrorizing a small town.
- Jesus Christ: Vampire Hunter: Dr. Praetorious, a Mad Scientist making vampires immune to sunlight.
- John Carpenter's Vampires has Jan Valek, the very first vampire, who also killed Jack Crow's crew and set him on the path of vengeance.
- John Wick series
- John Wick: Viggo Tarasov, The Mafiya don whose son killed the title character's dog, and who sends men to kill Wick in order to protect his son from the resulting Roaring Rampage of Revenge.
- John Wick: Chapter 2: Santino D'Antonio, a camorra boss who calls in an old debt to make Wick aid his power grab, only to then try and kill him to cover his tracks.
- John Wick: Chapter 3 – Parabellum: The Adjudicator, who orchestrates the hunt for Wick after he's excommunicated and goes on the run. Though they're really just an agent of the High Table. The one who does all the heavy lifting for the Adjucator is Zero.
- John Wick: Chapter 4: The Marquis de Gramont, a member of the High Table granted permission to do whatever is necessary to hunt Wick down and finally kill him.
- Jolly Roger: Massacre at Cutter's Cove: "Jolly" Roger Lafarge, a ruthless Ghost Pirate killing the descendants of his killers.
- Josie: Josie herself is a Serial Killer murdering everyone who framed and executed her father. Specifically, she came to the town of Baymont so she could murder ex-cop Hank.
- Judge Dredd: Rico Dredd, Dredd's brother who is plotting to destroy the Judge system.
- Jug Face: The Pit, an Eldritch Abomination who makes a town sacrifice people to it.
- Jungleground: Odin, a crime boss leading his gang in hunting a cop.
- The Jurassic Park films:
- Jurassic Park (1993): A Big Bad Ensemble with the Velociraptor named the "Big One", whose killing of a park worker at the start of the film sets the plot in motion, and the treacherous park employee Dennis Nedry, who hacks several park systems in order to distract the heroes while he smuggles dinosaur embryos from InGen to rival corporation BioSyn, leading to the escape of the Tyrannosaurus rex, among other dinosaurs, to attack the inspection crew and his employer John Hammond's grandchildren. Because he was the only one who could undo his own work (but wound up a casualty of his own sabotage when a Dilophosaurus kills him) and he left the Velociraptor exhibit untouched, the heroes' attempts to fix what he did lead to shutting the entire park down, which enables the pack under the "Big One" to become the final obstacle in the heroes' escape from Isla Nublar.
- The Lost World: Jurassic Park: Peter Ludlow, the Evil Nephew of John Hammond, who is desperate to save InGen following the failure of Jurassic Park and responsible for their operations on Isla Sorna to ferry dinosaurs to an abandoned earlier Jurassic Park in San Diego. His actions there, in addition to him discrediting Ian Malcolm, reducing the chaos theorist to a pariah, are what drive the story in motion.
- Jurassic Park III: While this film has no human antagonist, instead relying on encounters with other extinct animals, the Spinosaurus is the first predator that the main characters meet on Isla Sorna, and the most dangerous of the predators they have to escape from on that island.
- Jurassic World: Another Big Bad Ensemble, this time involving the Indominus rex, a super-hybrid dinosaur made on the base genome of Tyrannosaurus rex who engineers its escape and causes havoc throughout Isla Nublar, and Vic Hoskins, the overseer to Owen Grady's Velociraptor training program who seeks to have the Velociraptor weaponized for the military, and whose secret partnership with Henry Wu leads to the creation of the aforementioned Indominus rex as a means to get InGen to agree to use the Velociraptor. Hoskins winds up killed by a Velociraptor near the end of the film, so the conflict only ends with the defeat of the Indominus rex.
- Jurassic World: Fallen Kingdom: Eli Mills, the treacherous assistant to John Hammond's ex-partner Benjamin Lockwood, who opens a laboratory under Lockwood's basement right under his nose and tricks Owen Grady and Claire Dearing into helping him find the remaining Isla Nublar dinosaurs threatened by the cataclysmic eruption of Mt. Sibo under the guise of rescuing them, which is technically correct, just not for benevolent reasons, rather instead to start providing new genetic material and sell the dinosaurs in an auction. Another Big Bad Ensemble forms when an earlier operation on Isla Nublar recovered a bone from the Indominus rex, used to make its savage successor the Indoraptor, who the heroes have to defeat and prevent from being sold. Eli drives the plot in motion, and it only wraps up when he is defeated at the end.
- Jurassic World Dominion: Lewis Dodgson finally takes center stage after having been the one who made the offer to Dennis Nedry. His company, Biosyn, has engineered a locust outbreak to get people to buy his products, and his capture of Maisie is what ropes Owen and Claire into stopping him.
K
- Kaamelott: Premier Volet: Lancelot du lac had already graduated to Tyrant Takes the Helm in the series. Now he oppresses the people of the kingdom of Logres (or so that's what they say) and resistances arise against his reign, wishing for King Arthur to return (Arthur himself doesn't wish to return).
- Kagemusha: Oda Nobunaga, the rival warlord Kagemusha has to contend with.
- Kalifornia: Early Grayce, a murderer who hijacks Brian and Carrie's cross-contry roadtrip and leaves a trail of death behind him.
- The Karate Kid:
- The Karate Kid (1984): John Kreese, who runs the Cobra Kai dojo and encourages his students to use dirty maneuvers to win the All Valley Karate Tournament, though his top student Johnny Lawrence is the one who messes with Daniel for most of the movie.
- The Karate Kid Part II: Sato, a wealthy industrialist and old rival of Mr. Miyagi, though his nephew Chozen poses a much more confrontational threat than he does and after Sato turns good, becomes the Final Boss.
- The Karate Kid P Art III: John Kreese returns to this role, now with help from his old friend and business partner Terry Silver to make Cobra Kai bigger than it ever was before, though its Terry who does most of the work including screwing with Daniel and Miyagi's lives just for the hell of it, and their student Mike Barnes who acts as the main antagonist opposite of Daniel.
- The Next Karate Kid: Colonel Dugan, head of the militaristic Alpha Elite at the high school in this movie, with his student Ned being the one who harasses Julie through most of it.
- The Karate Kid (2010): Master Li heads the Thug Dojo in this movie, while his student Cheng causes most of the troubles for the protagonists.
- Keeper of Souls: Elaine Sloane, a cult leader making sacrifices to a demon.
- Keoma: Caldwell, a former Confederate soldier who has taken over a plague-stricken town.
- Kick-Ass: Frank D'Amico, who is responsible for much of the crime in the city as well as being the one who framed Big Daddy and sent him to jail.
- Kick-Ass 2: Chris D'Amico, who assembles a team of super-villain and goes on a crime spree in order to get revenge on Kick-Ass for his father's death in the first movie.
- Kill Bill: Bill, the leader of the Deadly Viper Assassination Squad who massacred The Bride's wedding party and the ultimate target of her Roaring Rampage of Revenge.
- The Killer (1989): Wong Hoi/Johnny Weng, Jeffery/Ah Jong's employer whose out to kill him.
- Killer Klowns from Outer Space: Jojo the Klownzilla, leader of an invasion of evil space clowns.
- The Killer That Stalked New York, a 1950 film Very Loosely Based on the 1947 New York City smallpox outbreak: Smallpox and the risk it poses to New York City is the main cause of conflict in the movie, though there is some conflict unrelated to it in the subplot about Patient Zero Sheila Bennet's personal life.
- The Killing of Satan: Satan, who has kidnapped Lando's daughter to make her his bride.
- Kind Hearts and Coronets: Louis Mazzini, who plots to kill his estranged family, the D'Ascoynes, as revenge for leaving him and his mother in a life of poverty.
- Kindergarten Cop: Cullen Crisp, a drug lord hunting for his wife and son.
- King Arthur (2004): Cerdic, the warchief of the Saxons who leads a brutal campaign across Britannia to destroy all in their paths.
- King Kong (1933): King Kong, a giant gorilla who terrorizes a native tribe and later New York City.
- The Kingdom (2007): Abu Hamza, the mastermind behind the bombing of an American housing compound in Saudi Arabia.
- The King of Comedy has Rupert Pupkin, who terrorizes his comedy hero, Jerry Langford, in hopes of getting on his show.
- Kingdom of Heaven: Saladin, who leads the Saracen army in their attack on Jerusalem, and Guy de Lusignan, who actively escalates the conflict between the Christians and Muslims in hopes of starting a war.
- Kingsman:
- Kingsman: The Secret Service: Richmond Valentine, who wants to make most of the world kill each other to stop overpopulation.
- Kingsman: The Golden Circle: Poppy Adams, who uses tainted drugs to pull a Poison and Cure Gambit on the whole world, holding millions of people hostage to force the legalization of her drugs. There's also the US President and Agent Whiskey, who while not working together are in agreement to let all the drug users die to both stop Poppy and end the drug trade.
- The King's Man: The Shepherd, aka Major Morton, is the leader of the Flock, a secret society that engineers and plays both sides of World War I as part of a plan to completely topple Europe's aristocracy.
- Kiss of Death: Tommy Udo, a killer aquited from murder out to get revenge on Nick for ratting him out to the police.
- Kiss of the Dragon: Inspector Jean-Pierre Richard, who frames Jian for the murder of a drug lord.
- Konga: Dr. Charles Decker, who kidnaps and experiments on the titular gorilla before having him murder his enemies so he may continue his research.
- Krrish 3: Kaal, the head of Kaal Pharmaceuticals who aims to wipe out humanity through the spread of viruses.
- Kung Fury: Adolf Hitler, the Kung Fuhrer, who has come forward in time to battle Kung Fury for his power.
- Kwaidan:
- "The Black Hair": The samurai's first wife, who died after he left her and seeks a terrible vengeance.
- "The Woman of the Snow": The Yuki-onna, a snow woman who freezes people to death.
- "Hoichi the Earless": Emperor Antoku, who presides over a court of life-draining phantoms.
- "In a Cup of Tea": Heinai Shikibu, a ghost seeking vengeance on the samurai who drank his soul.
L
- L.A. Confidential: Dudley Smith, who wants to take the niche left by Mickey Cohen and will not share it with any possible collaborator like Pierce Patchett or Sid Hudgens.
- Labyrinth: Jareth the Goblin King, who lures Sarah into his labyrinth by kidnaping her little brother, with the goal of making him her queen.
- The Lady from Shanghai: Elsa Bannister, who murders her partner and frames Michael for it.
- Lady in the Water: The Scrunt, a vicious wolflike creature that wants to kill Story.
- The Lair of the White Worm: Lady Sylvia Marsh, a reptilian vampiress plotting to summon her dark god.
- Land of Oz:
- The Wizard of Oz: The Wicked Witch of the West, who menaces Dorothy throughout the film and serves as the biggest obstacle to her safe return home.
- The Wiz: Eveline, a witch and sweatshop owner responsible for all of the obstacles that hinder Dorothy and her friends' journey on the Yellow Brick Road.
- Return to Oz: The Nome King, the new ruler of Oz who usurped the throne in Dorothy's absence after finding the Ruby Slippers.
- The Witches of Oz: The Wicked Witch of the West/Billie Westbrook, whose plan to get the key drives the plot.
- Oz the Great and Powerful: A Big Bad Duumvirate between Evanora, the Wicked Witch of the East and Theodora, the Wicked Witch of the West. Though, Evanora is the films true Big Bad, being the one who manipulated Theodora into becoming evil in the first place.
- Lassie Come Home: The Duke of Rudling, who buys Lassie and actively prevents him from returning to his real home.
- Last Action Hero: Mr. Benedict, who acts as the brains behind Tony Vivaldi's operation before using Danny's magic ticket to escape to the real world and cause chaos.
- The Last Airbender: Fire Lord Ozai, the leader of the Fire Nation who organizes the invasion of the Northern Water Tribe and intends to kill the moon spirit; with General Zhao acting as The Heavy.
- The Last House on the Left: Krug Stillo, the leader of the gang who raped and killed Mari Collingwood and her friend, leading her parents, whose house they happen to be staying at, to seek revenge.
- The Last King of Scotland: Idi Amin, a seemingly benevolent ruler of Uganda who his personal doctor, Nicholas Garrigan, gradually discovers is actually a brutal dictator oppressing the people of Uganda.
- The Last of the Mohicans: Magua, who seeks vengeance on the family of Colonel Munro, putting him at odds with the Mohicans, the film's heroes.
- The Last Samurai: Omura emerges as the main villain, who uses brutal and dishonest means to force through his own vision of Japan's future as a modern, ruthless Western-type industrial state (with himself in charge).
- The Last Temptation of Christ: Satan, who attempts to tempt Jesus into not sacrificing himself to save humanity.
- The Last Witch Hunter: The Witch Queen, who wants to destroy all humans.
- Law Abiding Citizen: Clyde Alexander Shelton, who uses his engineering expertise to get revenge on those who contributed to letting the murderer of his family go free and sets out tear down what he views as a corrupt justice system by spreading chaos throughout the city.
- The League of Extraordinary Gentlemen: The Phantom (actually M, whose real identity is Professor James Moriarty), who wishes to engulf the world in war so may profit off it and plans to replicate the League's abilities and sell them to the highest bidders.
- Lean on Me: Leonna Barrett, who heads the campaign to have Clark thrown out of the school.
- Legend (1985): The Lord of Darkness, who wants to kill all the unicorns and consume the world in ice.
- Legend of the Red Reaper: Ganesh, a depraved demon king hunting down his daughter.
- The Legend of Wasco: Wasco, the leader of a group of Serial Killer clowns who terrorize the town.
- Legion of the Dead: High Priestess Aneh-Tet, a Mummy plotting to awaken a dark god.
- The Leopard Man: Dr. Galbrauth, a Serial Killer using leopard attacks to cover his crimes.
- Leprechaun: Lubdan, a sadistic leprechaun seeking his gold.
- Lesbian Vampire Killers: Carmilla the Vampire Queen, progenitor of the Lesbian Vampire curse.
- Let the Right One In: Conny, the Barbaric Bully who leads Oskar's torment.
- Lethal: Anatoly Federov, a Russian mob Arms Dealer stealing government secrets.
- The Lethal Weapon tetralogy:
- General Peter McAllister in Lethal Weapon, a former army official who is making money with heroin shipments.
- Arjen Rudd in Lethal Weapon 2, a South African diplomat who is using his position to make money with drugs.
- Jack Travis in Lethal Weapon 3, a former police officer who is making money with stolen guns.
- The Four Fathers in Lethal Weapon 4, imprisoned Triad bosses using Dragon-in-Chief Wah Sing Ku to get out of prison with counterfeit money.
- The Life of Émile Zola: Major Walsin-Esterhazy, a spy for the Germans, sending them sensitive info about French armament and military plans; with Dreyfus getting accused and convicted of his crimes.
- Lights Out (2016): Diana, an abusive childhood friend to Sophie who, after becoming a ghost thanks to an experiment gone wrong, torments and drives away everyone in her life so she can have her all to herself.
- The Limehouse Golem: Lizzie Cree, a Serial Killer stalking London's Jewish community.
- Lincoln has George H. Pendleton. As the de facto leader of the Democratic opposition to the 13th Amendment, he's the biggest obstacle in the way of its passage.
- The Lincoln Lawyer: Louis Roulet, the murderer as Mickey Haller's case, and Mary Windsor, Louis' mother, who's willing to murder lawyers to protect her son from being punished for his crimes.
- Little Evil: Satan, who plots to ascend to the Earth by having his son sacrificed.
- Little Shop of Horrors: Audrey II, the self proclaimed "Big Green Mother from Outer Space" who eats everyone in the city.
- Living Dead Series
- Night of the Living Dead (1968): Harry Cooper, the {[Jerkass}} who stands between our heroes and surviving the zombie attack.
- Dawn of the Dead (1978): Blades.
- Day of the Dead (1985): Captain Henry Rhodes.
- Land of the Dead: Paul Kaufman.
- Diary of the Dead: Sergeant Nicotine Crockett.
- Survival of the Dead: Seamus Muldoon.
- Night of the Scarecrow: An unnamed warlock possessing a scarecrow to avenge his prior murder.
- Lock Up: Warden Drumgoole, who spends the film endlessly hounding Frank for the purposes of petty revenge.
- Lockout: Alex and Hydell, who lead the prison riot on the MS One and take the president's daughter hostage; with Snow having to rescue her from them.
- The Lone Ranger (2013): Latham Cole, who wants to destroy the Comache people so he may take the silver within their riversand build his empire.
- Long Pigs: Anthony McAllister, a cannibalistic Serial Killer being filmed for a documentary.
- Looney Tunes: Back in Action: The ACME Chairman, who seeks the Blue Monkey so he can use it to enslave mankind.
- Lord of Illusions: Nix the Puritan, an Evil Sorcerer plotting to destroy the world.
- The Lord of the Rings: The Dark Lord Sauron is the primary driver of the plot. As the trilogy begins, he is poised to conquer all of Middle-earth, and his victory will become assured if he captures the One Ring. He kick-starts the plot by sending the Ring-Wraiths to take the Ring from Frodo, he corrupts Saruman into attacking Rohan and kidnapping two of the heroes in the second film, and he musters a massive force to attack Gondor (and is mentioned in dialogue to be attacking all other good-aligned nations) in the third film. The plot isn't resolved until the Ring is destroyed, killing Sauron and leaving his forces leaderless and easily routed. In addition to him, Gollum, the previous bearer of the Ring before Bilbo, acts as a more direct threat to Frodo. Though while Gollum is able to be in an Enemy Mine with Frodo and Sam throughout the second film and guide them to Mordor in the third, his possessive desire to reclaim the Ring begins to take a hold as they get closer, and he betrays them when they are there, actually succeeding in grabbing the ring via biting Frodo's finger off, if only to fall into Mount Doom with it.
- The Hobbit, as a prequel to The Lord of the Rings, has two major enemies that Bilbo, Gandalf, and the Thirteen Dwarves must face. The main driving force of the conflict is Smaug, the dragon that took over Erebor and drove out the dwarves to claim their gold and jewels. However, as Smaug doesn't directly encounter the dwarves yet, the first film in the series, The Hobbit: An Unexpected Journey sees Azog the Defiler, whom killed Thorin's grandfather Thror, and whose orcs took over Moria, Spared by the Adaptation with a severed arm courtesy of Thorin, and as the most direct threat faced in the film, pursuing the main characters throughout the film and nearly succeeding in catching them. In the second film, The Hobbit: The Desolation of Smaug, Azog remains in pursuit early in the film, before being revealed to answer to The Necromancer, and therefore stays at Dol Goldur while his son Bolg continues the pursuit of the heroes. The Necromancer is actually Sauron, planning a war long before the one that took place in The Lord of the Rings. The dwarves and Bilbo eventually arrive at Erebor, and they finally confront Smaug for the first time, though they are unable to kill him and prevent his attack on Lake-town. Smaug winds up a Disc-One Final Boss in the final film of the trilogy, The Hobbit: The Battle of the Five Armies, killed by Bard, and Sauron is promptly exiled to Mordor by the combined forces of Galadriel, pre-Face–Heel Turn Saruman, and Elrond, leaving Azog to lead the invasion over Erebor and confront the heroes one last time.
- The Lost Boys: Max, a vampire pack leader trying to corrupt a family into joining him.
- Lovely But Deadly: Honest" Charley Gilmarten, a drug boss planting dealers in the local high school.
- Lucky Number Slevin: A Big Bad Ensemble between The Boss and The Rabbi, both of whom force Slevin to pay off his friend, Nick Fisher's debts to them, one way or another.
- Lycan: Isabella's adopted mother turns out to be the real one. She's a killer and is implied to have turned Isabella into one too. As the last Burt, she's stated to be carrying on a legacy since Emily Bunt, who's been identified in legend as a murderous werewolf (whether real or not is unclear).
M
- Macbeth: Macbeth, who murders King Duncan in order to take his place on the throne and kills anyone who comes close to finding out his crimes.
- Machete: Rogelio Torrez, who intends to close the US-Mexican border so he can control the entire drug trade due to knowing all of the weak points.
- Machete Kills: Luther Voz, the head of Voz Tech who plots to end the world by having nukes launched at every major country so he may start a new one made in his own image.
- The Machine: Director Thomson decides to use the Machine as a weapon against her creator's wishes, and later holds the brain recording of Vincent's dead little girl hostage to get him to obey.
- Mad Dog Morgan: Superintendant Cobham, the Corrupt Politican pursuing Morgan.
- The Mad Monster: Dr. Lorenzo Cameron, a Mad Scientist setting his werewolf on the establishment who called him mad.
- Madhouse (1974): Herbert Flay, a madman killing people disguised as a famous movie monster.
- Madman has Madman Marz, a man who killed his family and who will do the same anyone else unlucky to cross him.
- Mad Max:
- The Toecutter, the gang leader who killed Max's family, in the first film.
- Lord Humungous, who's leading a raiding party to take a town's oil, in Mad Max 2: The Road Warrior.
- Aunty Entity, the Well-Intentioned Extremist leader of Bartertown, in Mad Max: Beyond Thunderdome.
- Immortan Joe, master of an empire of slaves, in Mad Max: Fury Road.
- The Magic Sword: Lodac, an Evil Sorcerer who's holding a princess hostage with his dragon.
- The Magnificent Seven (1960): Calvera, a Bandito whose criminal army steals from a Mexican town, prompting the villagers to hire the titular Seven.
- The Magnificent Seven (2016): Bartholomew Bogue, a Robber Baron and Corrupt Corporate Executive who takes over the town of Rose Creek for the gold.
- Malignant: Gabriel, an entity with mysterious connections to Madison Lake-Mitchell's frequent visions of people experiencing gruesome deaths.
- The Maltese Falcon: A Big Bad Ensemble between Kasper Gutman and Brigid O'Shaughnessy. Gutman is the leader of the band of crooks chasing after the Falcon, while Brigid is revealed at the end to be the one who murdered Miles.
- The Man with the Iron Heart: Reinhard Heydrich, whose rise to power kickstarts The Holocaust.
- The Man from U.N.C.L.E.: Victoria Vinciguerra, a Nazi sympathizer who seeks to start a war for fun and profit.
- The Man from Toronto: At first it seems like an assassination attempt on the Venezuelan president is the main villainous scheme, and that is indeed thwarted by Teddy and Randy's efforts. Then it turns out that The Handler, Randy's hidden contact, is behind the attempts on Randy's life, wanting to tie up loose ends relevant to her network of assassins and make off with the money the Venezuelan assassins had offered in exchange for the network's services.
- Man on Fire: Daniel Sanchez, the leader of a feared, powerful kidnapping ring.
- Man of Tai Chi: Donaka Mark, the head of an underground fight ring who sells his fights by driving good men into becoming killers; with Tiger Chen being his latest target.
- The Man with the Iron Fists: Silver Lion, who did a coup d'erat on his clan to lead them in stealing some government gold.
- The Man Who Shot Liberty Valance: Liberty Valance, an outlaw gang leader working for the cattle barons in order to prevent territory that Shinbone is in from becoming a state.
- Manborg: Count Draculon, leader of The Legions of Hell on Earth.
- Mandy (2018): Jeremiah Sand, the leader of the Children of the New Dawn who has Mandy kidnaped.
- Maniac (1934): Don Maxwell, an actor who murders a Mad Doctor and takes his place.
- Maniac! (1980): Frank Zito, the Villain Protagonist, who kills women and attaches their scalps to mannequins.
- Manos: The Hands of Fate: The Master, a cult leader seeking more brides.
- The Manson Family: Charles Manson, manipulative leader of a murderous hippie cult.
- Robert Rodriguez's Mariachi Trilogy:
- El Mariachi: Moco, who wants the titular mariachi dead after he unwittingly steals his ex-girlfriend.
- Desperado: Bucho, the cartel boss El Mariachi's hunting down so that the cartel will stop coming after him for killing Moco.
- Once Upon a Time in Mexico: General Márquez and Barillo, who are responsible for the deaths of El Mariachi's family and the targets he's assigned with killing.
- The Marksman: Mauricio, a high-level soldier with a Mexican drug cartel, is the film's main villain. He is a ruthless murderer who's hunting down a woman and her young son just to punish them for what her brother did (who is already dead at the cartel's hands while this happens after stealing from them).
- Mars Attacks!: The Martian Emperor, who has ordered his planet's armies to destroy the Earth.
- Martha Marcy May Marlene: Patrick, the leader of the cult whose rape of Martha serves as the source of her mental trauma.
- Martyrs: The Mademoiselle, head of a cult of torturers seeking the answers to the afterlife.
- The Mask of Fu Manchu: Fu Manchu, who's after the mask and sword of Genghis Khan; which will give him the power to have Asia launch an attack on the West.
- Masked Avengers: Lin Yung Chi, founder of a gang of masked killers.
- Masquerade (2021): Initially it seems Rose is the one in charge as she's apparently giving instructions to the burglars. Ultimately Daniel is the main villain, responsible for murdering Casey's parents and setting her on a darker path.
- Masters of the Universe: Skeletor, who has finally conquered Castle Grayskull and now seeks to uncover the secrets of the universe in order to become all-powerful.
- Matilda: Agatha Trunchbull is a ruthless, child-unfriendly principal who has ruled over the elementary school Matilda studies in with cruelty, and shows no compassion towards anyone whatsoever (not even, and in fact especially not, towards her own niece Miss Honey). Matilda, after being mistreated for the longest time and seeing her classmates get mistreated as well, practices her new powers to prepare a plan to get rid of her.
- The Matrix:
- The original trilogy has Agent Smith. He starts out as just another Agent in The Matrix who gets more character depth than the others (i.e, he's actively disgusted and angered by people instead of just being an emotionless drone), but after he comes Back from the Dead in The Matrix Reloaded and starts copying himself, the Machines are forced to reach a truce with Neo to stop him in The Matrix Revolutions..
- The Matrix Resurrections has The Analyst, as the power behind the current Matrix and the resurrection of Neo and Trinity.
- Mean Girls: Regina George, the Alpha Bitch of the school, who controls the social scene with an iron fist.
- Mean Streets has Michael Longo, a loan shark after Johnny whose looking to make him repay his debts.
- The Medium: The demon possessing Kanda "Mink" Yasantia, a gestalt of spirits seeking revenge against the Yasantia family for the crimes of their ancestors and the spirits of animals who find an "open" receptacle in Mink.
- Meet John Doe: D. B. Norton, the owner of Ann's paper wishes to exploit the John Doe movement for his own cynical political ends.
- The Meg: The titular shark that threatens the sea and that attacked Jonas Taylor.
- Meg 2: The Trench: A Big Bad Ensemble between the three escaped Megs, and Hillary Driscoll, while Montes serves as The Heavy.
- Memento has Leonard Shelby, who willingly deludes himself into murdering people so that he can have a purpose in life.
- Memoirs of an Invisible Man: David Jenkins, a corrupt CIA agent who hunts Nick down and intends to force him to serve them as a black ops assassin
- Men in Black: An unnamed bug alien seeking a powerful energy source to win an intergalactic war.
- Men in Black II has Serleena, the Queen of the Kylothians who she seeks out the Light of Zartha so she can use it to destroy Earth and Zartha and have her species rule the galaxy unopposed.
- Men in Black 3 has Boris the Animal, the last of the Boglodites who travels back in time to kill K and kickstart an invasion on Earth, with J having to also go back in time to save K and prevent the invasion.
- Men Behind the Sun: Dr. Shiro Ishii, a Japanese officer experimenting upon Chinese civilians.
- Metropolis: Doctor Rotwang, who actively fuels the conflcit between the wealthy elites and aims to destroy the city purely out of spite towards its ruler for stealing his girlfriend.
- Miami Connection: Yashiro the White Ninja, who is trying to take over the Miami drug trade.
- Miami Vice: Jose Yero, the local drug dealer running the Miami drug trade, with Arcangel de Jesus Montoya as the Greater-Scope Villain.
- Midnight Express: Hamidou, the abusive warden running the hellish Sağmalcılar prison that Billy's trying to escape.
- The Midnight Meat Train: The unnamed train conductor managing the monster-feeding operation.
- Midnight Run: Jimmy Serrano, a Mafia boss seeking an accountant who stole from him.
- Mighty Joe Young (1998): Andrei Strasser, who wants to kill and sell the titular ape as revenge for biting off his finger.
- Mimic has the Judas breed insects kidnapping and devouring the citizens of Manhattan.
- Mindhunters: Lucas Harper, the Serial Killer stalking the island.
- Minority Report: Lamar Burgess. He killed Anne Lively when she was clean from drugs and wanted to get Agatha back, manipulated the Precogs' minority reports to get free from murder and framed John for getting too deep inside the Anne Lively case.
- Misery: Annie Wilkes, an obsessed fan of Paul Sheldon who kidnaps him after his legs are broken in a car accident and forces him to write a novel that undoes the death of her favorite character while under her care.
- Mission: Impossible Film Series:
- Mission: Impossible (1996) has Job/Jim Phelps, a rogue IMF agent who stole the NOC List and is intending to sell it to Arms Dealer Max.
- Mission: Impossible II has Sean Ambrose, another rogue IMF agent who wants to release a deadly virus called Chimera and sell its counterpart Bellerophon to the highest bidder.
- Mission: Impossible III has Owen Davian, a ruthless Arms Dealer who wants to sell the Rabbit's Foot to the highest bidder, and corrupt IMF leader John Musgrave, who is working alongside Davian.
- Mission: Impossible – Ghost Protocol has Kurt Hendricks, a Swedish scientist who wants to start a nuclear war between Russia and America.
- Mission: Impossible – Rogue Nation has Solomon Lane, a rogue MI6 agent who leads The Syndicate.
- Mission: Impossible – Fallout has John Lark/August Walker, a mysterious terrorist who wants to use nuclear weapons to destroy 1/3 of the world's population as well as collapse the current world order, and Solomon Lane, who wants revenge on Ethan for capturing him and ruining his plans at the end of Rogue Nation.
- Mission: Impossible – Dead Reckoning has the Entity, though Gabriel does all the heavy lifting for it.
- The Mist: Mrs. Carmody, who forms a cult of terrified survivors with herself as the leader.
- Moloch: Feike, who made a deal with the god Moloch centuries ago to save her from being burned at the stake and lives still by ritually killing her host body and possessing her daughter.
- Monsieur Verdoux: Henri Verdoux, who marries and murders women to care for his family.
- Monster in the Closet: The closet creature terrorizing everybody.
- The Monster Squad: Count Dracula, the leader of the monsters seeking out an amulet that will open a portal to Limbo and destroy humanity.
- Monty Python's Life of Brian: Pontius Pilate, the ruthless governor of Judea.
- Mortal Engines: In a change from the novels, Thaddeus Valentine is the sole example here. He plans to recover MEDUSA and use it on the rest of the world to make London pre-eminent, murders Pandora and Crome when they try to stand against him and is ultimately responsible for the devastating attack on Shan Guo.
- Mr. Arkadin: Gregory Arkadin, a Georgian arms-dealer who wants to wipe out all traces and memory of Wasaw Athabadze, his real name and identity, by tracking down and killing all who knew him.
- Mr. Smith Goes to Washington: Senator Joseph Paine and James Taylor are the Corrupt Politicians who control a vast political machine and want to dam a major river, which would destroy the natural attractions that Mr. Smith wants to preserve.
- Mulan: Rise of a Warrior: Mengdu, a mountain prince leading the local tribes into war against China.
- The Mummy Trilogy:
- The Mummy (1999): Imhotep, a mummy and ancient Egyptian priest the heroes mistakenly release who unleashes the ten Biblical plagues onto Egypt.
- The Mummy Returns: Imhotep again who wants to overthrow Mathayus the Scorpion King.
- The Mummy: Tomb of the Dragon Emperor: Emperor Qin Shi Huang, an ancient Chinese warlord who seeks global conquest upon his resurrection.
- The Mummy (2017) has Princess Ahmanet, the titular mummy who unleashes terror upon the modern world upon her awakening.
- Munich: Ali Hassan Salameh, the man who orchestrated the Munich massacre and the primary target of Abner's team.
- Mutant Girls Squad: The Prime Minister of Japan, who has started a campaign of genocide against a bunch of mutants.
- My Bloody Valentine: Axel Palmer, a Serial Killer out to shut down a small town's Valentine party.
- My Darling Clementine: Old Man Clanton, the head of the outlaw family who's terrorizing the town of Tombstone.
- Mystery Men: Casanova Frankenstein, the old nemesis of Captain Amazing who's freed from the insane asylum and plans to destroy the city.
- Mystery Team: Robert, the culprit behind the killings.
- Mystics in Bali: The Queen of Leak, the Wicked Witch who turns Cathy into a vampire.