Gunslinger Girl plays this trope dead straight for tragedy: For the terminally-ill little girls of the title, it's either be made into a cybernetic monster that commits sanctioned murder for the Italian government, or die of sickness and Parental Abandonment.
The Claymores of the anime Claymore are half-human, half-youmahybrids that are generally a match for most ordinary youma. Why the Organization does not simply create an army of them (rather than their traditional 47) and exterminate the youma is never explained, though it likely has to do with the danger of too many of them slipping through the control process and becoming Awakened Ones, which have the mind of a youma and drastically increased powers. Having a lot of AOs and no more source youma from which to create more Claymores would be kinda bad.
It has also been suggested that the Organization itself is responsible for the presence of the youma in the first place; after all, the Organization's Claymores are the only ones who can reliably kill them, and villages have to pay ridiculous sums of money to get a Claymore to come and save them from a youma. Villages that fail to pay afterwards are said to get wiped out by youma soon after...
It goes further than that, as recent chapters have confirmed that the Organization are responsible for the existence of Yoma (if possibly indirectly). The entire continent is, in fact, a testing ground to create controllable Super Soldiers in order to fight a war for a much greater empire struggling against an equally powerful enemy.
The Artificial Mages and Combat Cyborgs in Magical Girl Lyrical Nanoha, which turn out to be secretly supported by the higher-ups of the Time Space Administration Bureau themselves so they can have a steady supply of combat-capable mages.
The Headdliners of The Five Star Stories, who are not supersoldiers per se as they are born with their powers, but this is because they are descended from actual genetically engineered supersoldiers. While typically serving as Humongous Mecha pilots as they're the only ones with reflexes fast enough to properly control the things, they're no slouches in hand to hand combat, either.
Capable of taking a bullet to the head inbetween the eyes, and surviving without any regeneration period.
Fullmetal Alchemist has Olivier Armstrong being introduced to an army of artificial "humans". Souls of those killed in Amestrian wars are collected and infused into white, emaciated, nigh-immortal bodies created by alchemy. The goal of the Amestris high command was to use these puppets to replace their human armies, creating more soldiers from the souls of their fallen enemies.
There's also the "perfected" human chimerae.
In the 2003 anime version, they are implied to be the results of both a project to make powerful soldiers and because they knew too much about the government's nasty little misdeeds.
Wrath is basically this: a man trained to the peak of what the human body can endure and then subjected to an experiment that increased his physical abilities ten-folds, made him more durable and slowed-down his aging. His eyes were especially augmented, being able to process information almost immediately and never missing anything.
Gundam has had quite a few of these through the years...
You are encountering an Artificial Newtype. They are rather similar to Cyber-Newtype's having being artificially given Psychic Powers, through the process is different. Cyber-Newtypes are made, Artificial Newtypes are born through cloning and manipulation at the DNA level through drugs. They, too, receive some manner of therapy and military training... but aren't as unstable as there cyber-newtype counterparts (through not known to be sane either). The first known one(s) are based on Elpeo Puru with Puru Two. It turns out that Neo-Zeon made more than one. Much more.
The Human Reform League super soldiers from Gundam 00, made from artificially born, gene-boosted and nanotech-enhanced humans. The exact nature of the program that created them is kept in the dark to the viewers, but judging by their only surviving alumni (one sane but Emotionless Girl working in the HRL military, and one Split PersonalityAx-CrazyPhlebotinum Rebel who killed all the others and destroyed the program headquarters) and the public backlash the HRL suffered after it was revealed to the world, it was not exactly the prime definition of a 'success'.
Heero Yuy of Gundam Wing also fits this, but actually got his ranking in this category through sheer training and force of will. Although, being able to bend steel bars with his bare hands tends to make one think otherwise.
The entire point of the Radam invasion in Tekkaman Blade is to turn Earth into more Super Soldiers. They partially succeed, turning a large part of the population in "Primary Bodies", who can partially transform, but have no weapons.
Alita and the other Panzer Kunst warriors of Battle Angel Alita. They are of the cyborg variety of super soldiers.
Chise in Saikano. In addition to being a cybernetic weapon for the JSDF, she is a high-ranking officer.
Then again, Chise is less like a super-soldier and more like a living weapon of mass destruction. A super-soldier can take down entire battalions. Entire armies, sometimes. Chise can take down the entire fucking human race. And in the end of the series, she does.
The Invisible 9 of Pumpkin Scissors are nine whole units of super soldiers. For example; 901-ATT is the unit full of soldiers who can take on tanks and 908-HTT are soldiers that take down their enemies with flame throwers. However, just knowing that they exist seems to mean death...
There are elite cyborg troops in Ghost in the Shell world who can wipe the floors with regular soldiers. Most of the show's protagonists are former members of such teams.
One of the chapter titles in the manga is "Super Spartan"
Dracula in the original work was already a pretty bad mofo. In Hellsing, though, experimentation by the Hellsing family has enhanced Alucard's powers to the point where he is, among other things, not worried about losing his head.
The Jinchuuriki of Naruto are one part this, one part Attack Animal, depending on how they are viewed. It varies.
Actually, the ninja themselves are basically this. There are also plenty of ninja- sometimes entire clans- who have been modified through "permanent jutsu" to enhance themselves further; this is more or less taken for granted, at least by more experienced and older nin, though the likes of Orochimaru or Sasori are usually regarded as having gone overboard.
Every member of Akatsuki could count as going overboard, not just Sasori and Orochimaru. Deidara turned himself into a walkingnuke, Itachi has his MangekyoSharingan, Kakuzu is a conglomerate of other people's body parts, Kisame fuses with Samehada, Hidan's immortality jutsu, the Six Paths of Pain, Konan's attack with 600 billion paper bombs...
In the manga Kieli, the main character Harvey is an 'Undying'; an undead soldier that was created from the corpse of a soldier who had died in combat. Upon being reanimated, the Undying are nigh-unstoppable. They don't have any more strength or speed than a regular human, but they aren't affected by pain (although they still feel it), they don't age, do not need nourishment or sleep, and they can take nearly any amount of damage and keep going. Harvey, at one point, had half of his head blown off, along with one leg and an arm. Though it took months, he recovered. The only way to kill an Undying is by ripping its 'core' out of its chest, as the core is what gives them animation. After the war, the Church (who originally created the Undying to win the world war they were fighting) began to hunt them down and slaughter them mercilessly, offering a massive bounty for anyone who located or killed an Undying. Despite being technically dead, the Undying still have the same emotional capacity and personality that they did when they were alive, so the scant few who escaped the Church's massacre went on the run. At the beginning of the story, Harvey has been avoiding the Church for eighty years and counting.
Mai-Otome may well feature the only school for Super Soldiers that includes embroidery and ballroom dancing as part of the curriculum. Garderobe does not skimp on the traditional surival and combat training though.
Mewtwo from Pokémon was cloned from Mew and then gentecially altered to be the strongest pokemon in the world.
The Titan Shifters from Attack on Titan. Even without overtly using their powers, four of them placed in the Top Five of their military class while the fifth intentionally slacked off. Their powers make them insanely tough, with a Healing Factor that makes killing them nearly impossible — decapitation is the only method known for killing them. Combine this with their ability to transform into a Titan, while retaining all their human intelligence and it becomes clear just how grim humanity's chances are. It only took three of them to nearly destroy what remains of the human race.
Captain America began as the first of what was to be an army of super-soldiers, but after he was altered the creator was killed and the process was never successfully duplicated. This was eventually retconned to be part of the Weapon Plus program. Has a good claim on being the Trope Namer.
There have been several failed attempts to recreate Captain America, none of which have worked out well. U.S. Agent was probably the closest thing to a success, if only because he's still alive and a hero.
In the X-Men: Evolution adaptation, this is changed to the treatment being eventually fatal, leading Cap and Logan (later Wolverine) to destroy what they thought was the only Project: Rebirth capsule. Ironically, in this case there was a backup, which the X-Men then need to go destroy after it is discovered by Big Bad Magneto.
In the Ultimate Marvel universe, the supersoldier program was restarted in the 1990s and by the early 2000s several nations and alliances had their own versions producing Persons of Mass Destruction. The final issue of Volume 2 of The Ultimates mentioned a Superhuman Test Ban treaty that was to be signed to stop the continued escalation.
It's implied that many of the characters in the story were born from an attempt to recreate the super soldier serum. It's stated outright that the experiments that eventually led to the creation of The Hulk were initially attempts to recreate the super soldier serum. The genetic modification of spiders that later created Spider-Man also has its roots in the super soldier project.
Also in Ultimate Marvel - the creation of Captain America scared the bejeezus out of the Soviet Union, who started their own attempts at creating a super-soldier. But, apparently, there were budget considerations, so in their case it consisted of cutting bits of the Ultimate version of the Vision (who had crashlanded in Tunguska in 1908) and sewing them onto live human subjects. The results were... less than successful. After the dissolution of the USSR, eventually the human employees just left the bunker where the labs were housed, locking up and leaving the "super soldiers" to their own devices. When the Ultimates and the X-Men worked their way in about a decade later, the survivors were extremely disgruntled.
Wolverine and the other products of the Weapon Plus program (of which he was Weapon X).
Deadpool (another beneficiary of the Weapon Plus program) at one point faces off against Cap with a spiel about two wary super-soldiers watching, respectful yet wary...until Hercules runs out of fuse.
Fantomex (Weapon XII) and Huntsman (Weapon XIII) were both created from nanotechnology. While Fantomex was intended to be a poster boy for a Mutant hunting superhero team he mostly spends his time now working with X-Factor. Huntsman on the other hand was essentially a walking version of The Virus that infected anyone he touched taking over their mind.
Similarly, X-23, an attempt to produce a controllable Wolverine.
The Nova Corps, who are a mix of this and Space Police (depending on who is writing)
The Fifty State Initiative - California's The Order is essentially a grouping of applied phlebotinum media darlings; a team crafted to be popular AND powerful. One of the few teams that Tony Stark had a personal hand in building. Unfortunately, these superbeings have a time-limit on their careers: each person is under contract for only one year (otherwise the idea would get "stale", plus their granted powers might kill them). They also experimented with using Bannermen, mass produced super soldiers inspired equally by Captain America and the Hulk, as team members, but the idea was scrapped after Bannermen Green and Brown died fighting the Infernal Man.
The immortal Evilutionary Biologist called Apocalypse likes to enhance his already super-powered mutant follower/slaves into armored killing machines, while giving them subtle nicknames like "the Four Horsemen".
Beta Ray Bill was the 'winner' in a competition to create a powerful guardian for his people as they fled the destruction of their homeworld and a demonic invasion. The magic hammer simply added to his considerable power.
Rogue, the Rogue Trooper, is the last survivor of a unit of genetically-engineered super-soldiers who were massacred when one of their generals betrayed their strategy to the enemy, leading to a massacre. GIs are stronger and faster than humans, immune to all known poisons, and can go longer without sleep.
Friday, Rogue's successor, is the last of a group of GIs "tested to destruction" against three waves of attack (soldiers, armoured assault, and prototype versions of his unit) after taking an enemy stronghold.
Zenith: The Nazis got some cheat codes from a few Eldritch Abominations on how to make a superman, the British stole that information during World War II, and afterwards attempted to recreate the process. The resulting superwarrior children came of age during The Sixties, promptly rebelled and became hippies, and... well, let's just say it didn't end well for anyone.
The Judges in Judge Dredd are paramilitary law enforcement rather than soldiers most of the time, but the combination of training regimen, childhood recruitment and occasional use of cloning puts them in this category. The Judda, being highly genetically engineered and raised to be even more fanatical, are a clearer example.
The Global Frequency story "Big Wheel" dealt rather graphically with a Super Soldier program gone very, very wrong.
Marshal Law is a satirical look at super"hero" veterans of a genetic war who had been enhanced and programmed for violence, then were unable to go back to normal lives.
The Venom compound was a synthetic high-grade steroid developed for a rogue general. Combined with hypnotherapy and subcutaneous Kevlar implants, it was used to create a set of six super-soldiers on the tropical island of Santa Prisca. It also nearly drove Batman mad with addiction, before he kicked the habit and shut down the project. Unfortunately the criminal government of Santa Prisca acquired samples of the drug, which led to testing on convicted criminals, which led to Bane...
The Manhunters (Which are either androids, Super Soldiers, or Badass Normals depending on which continuity we're paying attention to this week)
Lex Luthor's Everyman project (Which delivered, but with a nasty catch).
Superboy, the 90s clone one, was practically this. Project Cadmus wanted to make a Superman after The Death of Superman and after 12 failures, they were able to do so. With Lex Luthor's help, of course.
In Camelot 3000, dissidents and criminals are involuntarily converted to Neo-Men by oppressive governments: oversized, voiceless, unquestioning brutes used to suppress riots and political unrest. Sir Percival's reincarnation undergoes this transformation within moments of having his past life's recollections restored, but retains his own mind due to the memory-restoration magic's effects.
Phase sixers or Super Warriors from the IDW published Transformers comics are powerful enough to fight armies of other Transformers and destroy planets with ease. Transformers: More than Meets the Eye shows that they are created from normal Transformers.
The Pony POV Series has the Hooviets' Project Hybrid, a project devoted to creating powerful pony/deer hybrids soldiers. General-Admiral Makarov is the most successful of them and the only one still alive in modern day. He has immensely powerful magic and enough physical power to curbstomp Shining Armor. Subverted in that the experiment was supposed to be a complete failure, as even if it succeeded it'd have just resulted in pony/deer hybrids rather than Super Soldiers. Makarov's true form, a reality bending monster called the Shadow of Chernobull that altered history. It's also revealed that Makarov was the one responsible for killing the other hybrids so he could be unique.
There were two Super Soldiers in Captain America: The First Avenger: The first one was surprisingly Johann Schmidt AKA The Red Skull (he received the super-soldier formula first. However, it wasn't perfected yet, and, ala Kefka Palazzo, he was implied to have been driven even more insane than before and gained the characteristic red face as a result), the second was Steve Rogers, AKA Captain America, which was luckily perfected by that time. The fact that they have different personality traits also were influencing factors on their characterizations. It's also been implied that Bucky was also injected with a similar serum.
Interestingly, this is also the case in the 1991 Captain America film with Matt Salinger playing the title role. In the case of that film it's indicated that the red face was actually a disfigurement caused by the original process, first seen tested on a rat, and which is later perfected for use with Steve who comes out looking normal, if extremely powerful in build.
Hanna in Hanna comes from a secret government program that develops otherwise aborted fetuses into powerful soldiers.
Emil Blonsky / Abomination in The Incredible Hulk film starts out as a Super Soldier, thanks to work based on a certain WWII project we "later" see in more detail. When that still isn't enough for him to take on the Hulk, he injects himself with even more dangerous crap and full-on becomes the Abomination. Tony Stark later pops in to condescendingly remind General Ross why that program was put on ice.
RoboCop, though he was supposed to be a supercop rather than a soldier.
Soldier, wherein a Tyke Bomb who survives to middle age gets tossed aside by his creators... Only to stomp a mudhole in a platoon of the genetically engineered "new models" when they cross paths.
Universal Soldier used corpses as the base. However, the Unisols are just more then corpses that they reanimate. They're corpses of soldiers, marines and the like; that are exceptional compared to their fellow service members. They are retrieved from the battlefield, and brought back to life, using a complex procedure of freezing, surgery, Bio-Augmentation and reheating using deep-tissue electrical shocks, and then doped up on performance boosting drugs and the like. They then take it a step further using gene therapy, in Universal Soldier: Regeneration, and further more with false memories and mind control in Day of Reckoning.
In The Bourne Series it was hinted at that the operatives in Treadstone and Blackbriar, that includes the protagonist Jason Bourne, had some form of enhancements beyond simple Training from Hell. While they don't do anything quite superhuman they have an unreasonable amount of stamina, pain tolerance and mental acuity to the point you know they aren't quite normal. The fourth film, The Bourne Legacy, actually has it as part of its plot. The operatives regularly take specific pills that increases muscle density, gives them a mild Healing Factor and sharpens their mind. When cut off from that supply they suffer withdrawals and are threatened that they will revert to being "normal" without it. It was later revealed that the newer iterations of the Outcome operatives, the LARX operatives; had these improved traits and abilities; made into permanent parts of their physiology, via retroviral gene therapy.
In the Jet Li film, Black Mask; the operators of Squad 701 are this. The 701s were created by the Chinese Government, in order to deal with the escalating crime rate, caused by gang violence and drug distribution. The 701s were selected from elite military units, and subjected to a procedure known as a neurorectomy, in which they injected a chemical solution into their brain stems, chemically deadening the part of their brains responsible for pain, exhaustion and fatigue. Because of this, the 701s no longer feel pain to a large extent, nor are they affected by exhaustion and fatigue. This removes the psychological limitations on the Human body, allowing for them to push themselves harder then the average soldier. They were able to hit with enough force to break through concrete, fast enough to outrun automatic gunfire and dodge it and perform other incredible physical feats.
The downside to this process, is that it left the 701s impaired to physical trauma and wear and tear from overexertion, meaning that it was very possible for the 701s to die from internal bleeding caused by their superhuman performance. Another downside to this process, was that it left the 701s with impaired judgment and morality. Major troubles for the 701s started, when one of their own, went berserk and killed a bunch of police officers in the process. After this incident, the government terminated the project and had most of the 701s killed, with only a handful escaping and surviving out in Hong Kong. The protagonist of the movie, Simon/Michael (In the Chinese dub his name is Tsui) is a 701 attempting to lead a normal life, but is called back into action when his fellow 701s begin taking down gangs all over Hong Kong and begin to cause trouble for the police.
The Neo-Vipers from G.I. Joe: The Rise of Cobra stroll through massed assault rifle fire without any apparent ill effect, and one even continues on as normal even after being set on fire. More or less you have to shoot them in the eye (the only part without armour) or use anti-tank weapons to kill one. At the very least with Joe tech, aim for the head.
In Iron Man 3, Extremis makes people super strong with a Healing Factor capable of regenerating limbs in minutes and the ability to produce intense heat at will. Unfortunately the serum is unstable and many eventually explode with enough heat to vaporize anyone nearby.
In Cube Zero, the government soldiers are implanted with a chip and "reprogrammed" to become the perfect soldier, feeling no pain, getting superhuman strength and obeying orders without question.
Ender’s Game: Andrew 'Ender' Wiggin and the rest of the Battle School students; note that they were trained, not to fight personally, but as super-generals.
Dune: the Sardaukar. And, arguably, the Fremen once Paul and Jessica train them to be soldiers not individualistic killing machines. (Although even as the Atreides are falling to the Sardaukar, Fremen under the control of Liet Kynes are engaging Sardaukar and suffering losses that Thufir Hawat finds amazingly low (losing two of their own and killing over a hundred enemy). One wonders what might have come about if Thufir had not been ambushed before he could link up with Paul and Jessica.
Later, God-Emperor Leto uses the Sardaukar gene pool to breed the all-female Fish Speakers as his private enforcers.
Actually, they were created the same way. After the first batch turned out to be megalomanical killing machines, the government got the bright idea to kidnap someone who hated the whole concept of violence and force him to accept the cybernetic implants, with the notion that he would use his powers only if they were truly necessary.
The Uruk-Hai were Super Soldier Orcs in both book and film versions of Lord of the Rings. Notable in that though they're bred for it, they are speculated by Treebeard to be hybrids of human and orc. In the Movieverse, it's regular Orc and Goblins (which are the orc equivalent of Gnomes or Dwarves), capitalizing on Hybrid Vigour.
Subverted in the Lois McMaster Bujold short story "Labyrinth"; the 'super-soldier' was designed by a committee with no actual soldiers on it and is flashy but massively impractical. The effect is rather spoiled by the fact that the prototype frequently appears in later stories as a very effective soldier.
The super-soldiers in question would have been impractical to mass produce. Sergeant Taura functions quite well as an individual working in conjunction with human soldiers — most of the time. However, she requires large amounts of medical care due to her genetically engineered hypermetabolism, and most of her character development revolves around her continually beating the low odds her doctors give for her continued survival. She's basically written like an eight foot tall cancer patient with fangs.
It was mentioned that this project was intended to produce a commandos unit, not line grunts. And it basically reached its goal, if you're willing to overlook the radically shortened lifespan of an individual soldier. It's just that the country that ordered them was defeated before the project could be completed.
On the other hand, both people who easily trounced scrags were heavyworlder martial arts specialists: Thandi's literally a Space Marine, and Anton is a wrestling champion.
Once Thandi had given her amazon brigade of scrags some proper training, they became very effective soldiers.
The scrags really are on average much stronger, faster and even have and initial intelligence higher than the average person. Unfortunately they also know this and, combined with generations of inbreeding, has resulted in a subculture that is so absurdly arrogant about its own capabilities that they don't bother with proper strategy or even basic training.
Dahak's 'improvements' make a Fifth Imperium soldier a serious super soldier compared to a Fourth Imperium super soldier. Talk about helping someone Take A Level In Badassery.
The Colonial Defense Force from John Scalzi's Old Man's War. Earthborn humans are given the option to join the offworld military instead of retiring at age 75. Once off planet their consciousness is transferred to a genetically engineered body grown from their DNA. Notable in that the entire force from privates to generals consist of supersoldiers. (It's made very clear that unenhanced humans wouldn't last five minutes against the aliens they have to fight.) The Special Forces are much worse: they are born with the knowledge of how to be supersoldiers, and not much else.
In John Ringo's Council Wars series, the Elves are the virtually immortal genetically engineered superhuman soldiers of the last Resource Wars.
The Specials in Scott Westerfeld's Uglies series. They have bones made of aircraft material with servos inside for better movement, artificial muscles that are stronger and don't get sore, weaponized fingernails and teeth filed to sharp points, nanobots in their blood that allow them to heal quickly, antennas implanted in their skin to allow for more efficient communication between themselves, a direct link to the city's interface that they can manifest as a GUI by closing their eyes and thinking about it, and an artificial addition to their brain that gives them enhanced senses and reflexes, a serious superiority complex towards non-Specials, and violent tendencies. Oh, and their facial features are modeled to look vaguely lupine to stir up the primal fear of predators in unmodified humans.
In Daniel Keys Moran's Tales of the Continuing Time, the Peaceforcer Elites are made into Super Soldiers through a grueling series of gene therapies and cyborgizing surgeries. Tens of thousands of years ago, the Old Human Race made Super Soldiers through genetic engineering and sheer badassery. Additionally, the Unification's Project Superman experimented with gene modification to produce the de Nostri (a human-leopard mix), and a group of telepaths, both as attempts at Super Soldiers. One team was especially effective, consisting of a telepath (Carl Castanaveras), a Peaceforcer Elite (Christian Summers) and a de Nostri (Jacqueline).
Richard K. Morgan's Takeshi Kovacs novels feature a whole variety of augmentations and genetically engineered supersoldier bodies. However the premise of the universe (that FTL travel is only possible by beaming your consciousness to another planet and downloading yourself into a new body) means that the ultimate soldiers are 'Envoys' who undergo an intense mental version of The Spartan Way to condition them to fight effectively in a new and unfamiliar body.
Many of the Inchoroi "weapon races" in the Second Apocalypse series. Sranc (essentially rape-happy orcs) serve as mooks, since they have none of the morale problems human soldiers might. Bashrags (essentially ogres) and dragons are the "fewer, but higher quality" sort.
The Unsullied in George R. R. Martin's A Song of Ice and Fire, a type of eunuch slave soldier using armament and tactics similar to Greek hoplites. Due to brutal training and drug use from a young age, the Unsullied are robotically loyal, utterly fearless, and immune to pain. However, their castration during youth causes them to lack raw muscular power. They are also specifically not one man armies, being far more effective in their phalanx fighting formation.
The first sci-fi story Martin had published, "Hero" is about this trope. The protagonist is a heavyworlder raised and trained on a War World, with drugs used to maintain his speed and stamina. Despite his superior trying to disuade him, he decides to retire to Earth at the end of his enlistment instead of returning to his native planet like his colleagues, thinking he'll be a hero there instead of just another retired soldier. Instead he's murdered by his superiors who have no intention of letting such a dangerous person anywhere near ordinary humans.
Pepper from Crystal Rain. His body actually burns off a good fifty pounds over the course of a single fight, and he has to keep eating and drinking constantly during lulls in the battle to keep his metabolism running. So Badass that he actually came out of a And I Must Scream situation more or less unscathed.
Painless soldiers in the Inheritance Cycle. They are incapable of feeling pain, so they can fight with stuff like missing limbs and crushed sternums. Nothing is Squickier than fighting a laughing madman with only half a face. It's later revealed to be something of a deconstruction: those soldiers didn't feel pain, so they didn't exhibit a survival instinct, allowing them to be easily lead into traps.
The Shrike from the Hyperion Cantos- if a metallic nine foot tall, time-bending, godlike killing machine covered in spikes doesn't qualify as a supersoldier, nothing does.
Also Rhadamanth Nemes and her twins. They manage to take on the Shrike and survive. One of them even temporarily defeats it!
The serjants of the Night's Dawn Trilogy are also an example of this, as they are initially used to police Tranquility, and later used as the front line troops to fight the possessed.
The Trollocs from The Wheel of Time were intended to be this- in reality they're only mediocre at it, as while they are much larger, stronger, and more aggressive than humans, they're also lazy, undisciplined, and not very bright. Their effectiveness is improved greatly if one of their Myrddraal cousins is put in command, since they're smarter and have a variety of weird powers that includes the ability to telepathically coordinate Trollocs, making them far better warriors. Normally, though, the main use for Trollocs is the Zerg Rush, since there are a lot of them.
The Gholams can also be considered this since they are immensely strong, immune from magic and are essentially immortal
On the side of the Light Warders can be considered Super Soldiers since due to their bond with their Aes Sedai they gain increased strength and endurance. Combined with receiving the best possible training in the world and they are a formidable opponent
The koloss from Mistborn are artificially created killing machines that can take out whole squads of human soldiers by themselves, though they lack any real capacity for subtlety or tactics. Their primary drawback, though, is that they're berserkers- once a koloss army has been unleashed and gone into frenzy, they're nearly impossible to rein in until the frenzy has passed and will kill anything non-koloss (and sometimes other koloss too, if they can't get anything else) that crosses their path. This means that you can't deploy your koloss near human population centers you don't want levelled.
Comes up frequently in the works of Timothy Zahn, often also highlighting the drawbacks and pitfalls.
The title characters of The Cobra Trilogy Series are man-made supersoldiers originally created for a major war. They have unbreakable bones and numerous weapons built into their bodies. At the end of the first book (Well after the war ended), it is revealed that the process that made their bones unbreakable also caused people who underwent the COBRA treatment to become arthritic and anemic as they got older. This is in addition to the question brought up earlier in the book of what you're supposed to do with supersoldiers when there isn't a war going on.
Also in Zahn's Blackcollar trilogy: the Blackcollars are deliberately low-tech supersoldiers, created using drugs to enhance speed and strength, then equipped with low profile body armor and weapons like shuriken, nunchaku, and slingshots, in order to wage a guerrilla war against an enemy capable of tracking more advanced weapons.
In The Conquerors Trilogy, The Copperheads are cybernetically augmented humans capable of "Mindlink" with their fighter craft, to the extent where the highest level makes the pilot feel like they are the ship, and allowing the equivalent of instant telepathic communication among a squadron. For obvious reasons, they're incredibly effective in combat. Unfortunately, because the Mindlink is both highly stimulating and designed to suppress things like physical and emotional pain while it's active, it can become addictive and even cause brain damage if it's used more than absolutely necessary.
Deconstructed in Gladiator: Hugo Danner has a professor father who experimented on him as a fetus, so that he developed a reasonable degree of Nigh-Invulnerability and Super Strength. Trapped in World War One, he becomes a Super Soldier killing as many German soldiers as he can for the French Foreign Legion. He decides to win the war by Instant-Win Condition: hijacking a plane, infiltrating Germany and killing the German Emperor and his generals to force a Decapitated Army. Unfortunately, Reality Ensues and the war ends on his own accord. The truth is, modern wars (maybe since the nineteen century) are not won nor lost by soldiers anymore, but by economic and politic reasons out of any human being control.
In Sergey Lukyanenko's Line of Delirium, the protagonist, a professional bodyguard named Kai Dutch reveals that he was created as one of these in secret, as genetic engineering is illegal in The Empire. For the first 15 years of his life, he was a weakling and constantly bullied (and raped). Once he hits 16, he hits a huge growth spurt and develops superhuman strength, speed, reaction time, and analytical powers. However, even when he has to fight a Meklar hand-to-hand (normally a death sentence to any non-Meklar), he has a doctor (working for The Mafia) give him tons of "enhancements" and a "battle cocktail" that turns him into a killing machine that can survive a few minutes against a Meklar.
A Dry, Quiet War by Tony Daniel involves soldiers from a war at the end of time 15 billion years in the future, who are almost unkillable because their bodies extend into alternate timelines.
Their "brothers and sisters" made an appearance in several episodes of Enterprise.
These weren't created as super soldiers. Soong just wanted to make perfect humans. Unfortunately, their egos demanded more, and they began to see everyone else as inferior. A predictable reaction if ever there was one.
The IDW Star Trek Khan comics have Benedict Cumberbatch's version of the character stand trial after the events of Star Trek: Into Darkness and retell the story of the Eugenics Wars and why he looks nothing like Ricardo Montalban. A powerful corporation kidnapped a whole bunch of kids from slums all over the world in 1970s and, with backing by various governments, set out to train an army of Super Soldiers, genetically-enhancing them using tech unheard of outside the company, giving them a Healing Factor, among other things. Noonien Singh became the leader of the "enhanced" at the Indian compound. Eventually, all the enhanced all over the world coordinated their actions and escaped, deciding to plot a global takeover in order to keep the foolish humans from destroying the world. In 1992, they make their move by nuking Washington and Moscow and announcing their intentions. Their takeover takes a few weeks. After capturing India, Noonien Singh takes the name/title Khan and becomes the ruler of the Central Asian territory. According to him, he's the only ruler who tries to make the lives of his people better, while the others use their ambition to fight among themselves, which, in the end, allows humans to fight back and push the "enhanced" to Australia. Khan and his followers escape on the SS Bottany Bay. He then gets Easy Amnesia and is tricked by Admiral Marcus that he really is John Harrison, agent of Section 31. His memories return when he blows up Praxis as part of his mission.
TNG: Roga Danar and the other exiled Angosian soldiers, in "The Hunted", with a Vietnam Veteran Syndrome metaphor Anviliciously applied.
First the Jaffa, an actual human subspecies that was biologically dependent on having a Goa'uld larva inside them and later the nigh invulnerable Kull Warriors (who were actually often called 'Super Soldiers') in Stargate SG-1.
This trope was employed in the excellent episode "Eve" in season 1. The creepy twin girls came from a secret government's project. Its aim was to create and clone humans with superior strength and intelligence. Boys and men were called Adams, while girls and women Eves. Pity the clones suffered from severe psychoses and had suicidal and murderous tendencies. Easily one of the best episode from the first season. Great story-telling.
The second season opener of SeaQuest DSV centered around the "Daggers", genetically engineered warriors whose very existence was outlawed before they were a year old, and are exiled to life on a prison island. They are freed by the end of the episode.
The official term is GELF - genetically engineered life form. "Dagger" is an insult.
In some ways, it can be argued that she's a Deconstruction of the trope. Yes, she's a phenomenally dangerous living weapon, but she's also insane and barely functional as a person after what she went through to become a Super Soldier.
Though the end of the movie implies she does come to terms with this and got better.
Heroes had Scott, the Marine from the last couple of episodes in the third season.
Notably killed a few seconds after receiving his first combat assignment.
A few of these were created in The 4400. They were injected with Promicin, and the survivors of this made several appearances. However, they were "just" soldiers with superpowers, the latter of which is fairly common in this series, so they often got their asses kicked by 4400s or other P+ s.
In Dollhouse, one of Rossum's secret projects is to create a unit of Hive Mind-ed supersoldiers using Active brain-architecture used in conjunction with neural radios. The result is.... disturbing, to say the least.
The Initiative troops in season four were chemically augmented to be tougher, stronger, and faster than ordinary humans. They were still no match for Buffy herself, however, and since they were usually going up against the same type of critters she fought, they didn't show up too well.
Adam was meant to be the first line in a new (and better) line of Initiative Super Soldiers to the example mentioned above, combining the advancement of technology, the intelligence and adaptability of humans, and the superior strength and emotional detachment of demons in one big badass package.
The Nietzscheans of Andromeda, who fight not only outside enemies, but each other, constantly. Stronger, faster and tougher than humans, with bone spikes on their forearms.
The episode title is appropriate, as Lex's plan was to repeat the process and create an entire army of Super Soldiers for the US military (supposedly, anyway; this isLex Luthor we're talking about). Fortunately, the facility creating the soldiers was destroyed in a fight between Clark and Bizarro.
The Daleks are an entire race of these, albeit non-humanoid after extensive bio-engineering by their creator Davros.
And, to a lesser extent, the Sontarans.
In NCIS, a Marine who escapes from a mental institution (funded by a private military contractor) and is brought back in by Gibbs' team claims to have been experimented on, a claim backed up by cybernetic implants found in his body. When a company official for said private military contractor demands his return, it is suspected that he was an involuntary subject of a Super Soldier project. It turns out that he'd been self-medicating with steroids, and the 'implant' was a homing device placed after his return to the US.
The Cortexiphan kids from Fringe were trained to become this in the impending war between universes.
The show notably shows the downsides to having some of these powers, such as a telepath who can't bear being near other people and must live in isolation for the rest of his life, an empath who unintentionally causes other people to feel his depression and commit suicide, or a pyrokinetic who can't control her own flames.
In Defiance the Bio-Men were secretly developed in case of an alien invasion and deployed when the Votan appeared. They look less human than many of the Votan species being massive hulking humanoids with blue skin, no hair, numbers etched on their chests, and an "off-switch" that knocks them out until someone electrocutes them.
Space Marines (Imperium of Man): Fanatically dedicated, comprehensively superhuman genetically-engineered giants selected through decades of religious indoctrination and a form of The Spartan Way that only one of a hundred aspirants even survive, who carry fully automatic armor-piercing rocket-propelled grenade launchers as their basic gun, are strong enough to rip a man apart and can survive having a tank dropped on them. Among the more... interestinggenetic grafts and hormonal modifications are a second heart, a third lung, a second stomach, bones coated in naturally occurring ceramite, and a ribcage that is solidified into one large chunk of bone. On top of their large intelligence they also have the ability to eat the brains of enemies to incorporate their intellect. Their muscles are so thick that they are immune to any weapon smaller than a 9mm handgun, they can breathe water, they are immune to diseases, and they don't require sleep. If they are not killed, they will live forever.
Terminators (Imperium of Man): The Elite Imperial Space Marine - veterans of countless battles, the strongest and fittest and most capable of all marines. And they get a super-power armor (Tactical Dreadnought Armor) and even more obscene weaponry (like larger caliber gatling versions of said grenade launchers or Thunder Hammers that can rip tanks to pieces). They can also teleport. It's commonly agreed that battle brother becomes eligible to the First Company (where Terminators are grouped as per Codex Astartes) posting after at least a full century of service. And some chapters require even more.
Grey Knights (Imperium of Man): incorruptible Marines who are also great psykers, have a magic-immunity shield and a spear that shoots lighting for killing giant daemons. The selection process for Grey Knights involves, among other things, the "666 rites of the Emperor", which can be best described as 666 Mind Rapes.
Thunder Warriors (Pre-Imperial human): The precursors of the Space Marines used when the Emperor united Terra. Stronger and tougher than their successors, but with shortened lives and none of their non-combat utility.
Aspect Warriors (Eldar) dedicate every single conscious moment of their lives to training for a particular aspect of war, also utilizing the second-most advanced technology in the setting. Despite being of only average human dimensions, they can generally go toe-to-toe with the above-mentioned Space Marines.
Exarchs take this to the next level, as their entire existence is dedicated to combat. They never leave their shrines and have the best equipment of their respective aspect. In older editions they were Eldar heroes who had access to an incredibly wide range of Bad Ass wargear, even from outside their aspects, but they've been toned down to be more akin to Sergeants or typical squad leaders.
Stormtroopers (Imperial Guard, Imperium of Man): The Stormtroopers carry backpack-powered hellguns, heavy carapace armor, and - depending on the regiment - can receive genetic enhancements. In older editions, squad leaders could even carry powerfists or lightning claws.
The Orkz: Orkz are an entire race of Supersoldiers created byPrecursors, designed for the sole purpose of fighting. Whatever the Orks may lack in tactics and technology they make up for with More Dakka, more choppa, More Dakka, a total lack of fear, More Dakka, the ability to quickly infest worlds via their fungal lifecycle, and More Dakka.
Various Inquisitorial Assassins: Four Temples each with it's own breed of assassin dedicated to one of four major fields of combat: Sniping, Impersonation, Terror-Attacks, and Anti-Psyker. They are the Vindicare, Callidus, Eversor, and Culexus. These assassins have profiles in-game that rival/exceed that of most army leaders, are implied to be trained from birth (very little of their training proceedures is ever alluded to) and can only be deployed by authorization from a sanctioned Inquisitor, and even then said Inquisitor are never allowed to deploy more than one. The Eversor stands out among them, as he is usually only deployed when the inquisition needs to make an example of someone. His modus operandi usually results in the immediate area receiving a very visceral redecoration.
Rifts had several, developed by the governments of the world before it all came crashing down. Naturally, the technology to make them managed to survive, and in many places, any person with the inclination and a whole lot of cash can just pop over to the local Body-Chop Shop to get turned into a cybernetic, mentally- or chemically-enhanced killing machine. Specific examples:
Full-conversion 'borgs, those who choose to get their entire bodies replaced with metal save their brains; they also come in partial-conversion varieties, replacing only their limbs and some organs.
Crazies, who have microscopic implants in their skulls that grant exceptional strength and psionic powers, but slowly drives them mad; they're identifiable by the giant steel rods in their head, an anachronistic remnant of the old process that they insist upon, and the fact that they tend to act like cartoon characters.
Juicers, people who are chemically wired to operate at the absolute peak of human performance. The problem is that the constant manipulation of their blood chemistry slowly destroys their bodies; the maximum life span of a Juicer is six years. "Detox" is possible, but after five years has almost a 100% failure rate and only if done within two years will the individual not suffer from their body being partially burned out.
Notable examples developed After the End are Coalition States Battle Cats, Kill Hounds/Kill Cats, and Ursa Warriors, genetically engineered animal Super Soldiers. A similar project in South America resulted in the Amphibs of Tritonia, as well as two separate independent nations of primarily mutant animals.
Rifts being Rifts, nonhumans get in on the fun as well with their own Super Soldier creations. The aliens occupying Atlantis have the standard Juicers, Crazies, and 'Borgs, but they also have the Bio-Borgs, beings that are magically mutated and often enhanced with a wide variety of parasites and symbiotes. The results are often strange and disturbing, but extremely effective. The Kreeghor of Three Galaxies favor genetic manipulation: their Invincible Guardsmen routinely feature beings who have been transformed into living metal or who can change into pure light on a whim. In a larger sense, there are a number of nonhuman Proud Warrior Races who are capable of facing down most of the Super Soldiers on this list. For added fun, try applying any of the above Super Soldier creation techniques to one of these beings.
The Clans of the BattleTech/Mechwarrior Universe. Descended from the remnants of the Star League army that fled the breakup of the Star League, the Clans genetically breed their Mechwarriors, Infantry, and Aerospace pilots - only the top 25 individuals of a particular "Bloodline" are allowed to have children (they believe Lamarck Was Right). Clan Elementals (infantry) are 8-foot tall mountains of muscle, MechWarriors are of average height and weight but are immensely fit and have excellent reflexes, and the aerospace pilots have slimmer bodies and larger heads and eyes with enhanced reflexes and perceptions to give them the advantage in an Old-School Dogfight. In the game universe, this made them individually better (with a few individual exceptions), but few in number compared to the Inner Sphere pilots, born the "old fashioned way" (The same problem that eventually cost the Real Life Spartans their unbroken record of victory).
The Clan fighter pilots actually subvert this, as the Clan aerospace fighter pilot program is regarded as a failure by 3060 and outright obsolete by 3070; despite superior equipment and genetics, Clan fighter pilots consistently lose to Inner Sphere ones. It is implied that Clan emphasis on BattleMech clashes resulted in the retardation of their tactical and training development for fighter pilots as well as denying their pilots combat flight time, meaning that Inner Sphere fighter doctrine and training is a hundred years or more ahead of its Clan equivalent and most Inner Sphere fighter pilots have more experience!
Magic: The Gathering has the Metathran, genetically engineered soldiers created by Urza to fight the Phyrexians. For that matter, the Phyrexians themselves also qualify. They are born as humanoid creatures called Newts, which are already much stronger that normal humans, and are later compleated (not a typo).
Decommissioned Super Soldier-types are the focus of the Underground RPG.
GURPS: Bio-Tech features numerous different super-soldiers created through Bio-Augmentation. A few examples:
Orion's: A lower tech level super soldier who has enhanced reflexes and strength (not super human but very good nonetheless), improved metabolic performance and a high pain thresh hold.
Artemis: A more advanced all female super soldier race. They have enhanced strength, speed, durability and senses and can reproduce either sexually or asexually but suffer from inherent overconfidence and recklessness. They are also almost always bi-sexual or lesbian.
Guardian Warriors: Created to be super commanding officers, they have have the super human strength and speed typical of super soldiers, though to a lesser degree than most examples of this trope. However, they make up for it by being able to emit pheromones to manipulate others, having enhanced intelligence, an improved resistance to physical damage, poison and disease and by being universally attractive and all having sexy voices, making them all incredibly charismatic and persuasive.
Also, the Terrestrial Exalted were originally intended to be this; the Gunzosha were intended more to supplement their numbers than to be the backbone of their armies. Then the Usurpation happened, and the Terrestrials became the new aristocracy.
Solars can create these incredibly quickly with Tiger Warrior Training Technique and its expansion Legendary Warrior Curriculum. Tiger Warriors are generally considered in the fluff to be the most Badass soldiers mortals can be without special equipment, such as gunzosha armour. Mix in an Infernal to use Fealty-Acknowledging Audience and By Rage Recast to grant them power-enhancing mutations, and you now have a unit that nobody wants to get in front of.
Lunars aren't bad either, between Wolf Pack Training technique and Burgeoning Wyld Infliction they can both train and mutate mortals into make-your-own-super-soldiers, and with the right upgrades, they can add animals and even plants to the list of potential recruits. Of course, breeding your own army of beastmen is more fun, and they easily become self-sustaining if you do a good job.
d20 Future (the Sci-fi expansion to d20 Modern) features the Helix Warrior class, for players wishing to become super-soldiers. Also, the Genetic Engineering system presented in the book allows players to take this even further. It's possible to made a super-soldier with god-like levels of unkillability (assuming cost is no object).
Dark Sun nomadic mantis-folk Thri-Kreen are hatched as sleepless armored death machines. Tohr-Kreen (settled variety) consist of similar races or subspecies. But they got technology more advanced than anything in inherited memories of those savages and make "zik-trin" — enforcers or scouts large and hideously powerful compared to normal Kreen, mentally conditioned to absolute obedience to their controllers. Tohr-Kreen are reclusive and as Properly Paranoid as most sentients on Athas, so their only representatives met in other lands are such modified scouts with memories of their homeland location removed, doubling as missionaries to wild Thri-Kreen packs.
The ultimates in Eclipse Phase are trying to become these, and operate by a philosophy based on eugenics, asceticism and discipline. The problem comes when one goes over the edge and modifies himself into a predator exhuman, which could be roughly described as a Super Hunter that views everything else in the universe as targets and possibly food.
There are also a number of morphs designed as soldiers, most notably Furies, Ghosts, and Reapers.
Given the ample precedents set in superhero comics (above), naturally just about any superhero RPG can incorporate super-soldier characters without missing a beat. It's for example not at all an unusual origin for characters in the Champions setting, where canonically quite a number of both heroes and villains owe their powers to somebody's efforts to build the better mook — from villainous organizations like VIPER to the United States' own Department of Defense.
Any "Ultimate Weapon" revealed (and possibly fought) early in any game will eventually be fought more and more. In some cases, with more than one at a time. (See the Double El Gigante fight in Resident Evil 4)
Speaking of Resident Evil, the Tyrants are the best example of this trope in the whole series.
Albert Wesker might qualify, seeing how they injected himself with a virus that enhanced his strength, speed, agility, durability, and healing to superhuman levels, and the virus itself was strongly implied to be intended to be given to certain members of Umbrella to create new life for Spencer to rule as a god over.
It could be said that just about everything you encounter in the series is either this trope, or an attempt or side effect of creating this trope.
Not only that, she later gets infused with Metroid DNA, and has also been exposed to the highly volatile substance Phazon repeatedly. Additionally, her aforementioned Powered Armor can utilize virtually any weapon or technology it comes across, can hack into even the most secure networks just by LOOKING at it, and can determine the weakness of almost anything, animal or mineral, by the same process.
For bonus points, the word "metroid" in the Chozo language means "ultimate warrior."
Let's face it, in her universe she's a combination of Superman, Ironman, Batman, Wolverine and Green Lantern. No wonder most people don't even think she's real anymore. The alliance soldiers think she's just a myth of propaganda, and the Space Pirates perception of her seems to be leaning towards an Eldritch Abomination that exists solely to torment them for all eternity. It's Not like they don't deserve it, though...
Heck, Solid Snake's best friend was also a super soldier, as well, both during the events of Portable Ops (where he was a sole-surviving test subject of a CIA project to create the Perfect Soldier), and Metal Gear Solid (when he was made into a Cyborg Ninja).
Not to mention the Genome soldiers an attempt to create a army of Big Bosses quality soldiers from Metal Gear Solid.
And to a lesser extend almost every single active soldier in the word in Metal Gear Solid 4, thanks to the nanobots.
The regular soldiers too are transhuman specimens. They have simply received less augmentation, which is more in line with placing an untrained civilian on the level of your average soldier quickly rather than enhancing average soldiers to superhuman levels, like the Combine Elites. The only pure humans in the Combine military are the Civil Protection officers.
Combine Elites? No, two words: Gordon. Freeman.
MCPO John-117 and the other SPARTAN-II cyborgs in the Halo series. It initially consisted of 75 trainees, chosen by way of genetic markers indicating for exceptional athleticism and intelligence, who were abducted and conscripted into the special forces at age six, trained into perfect warriors until age 14, and then subjected to a series of augmentations that rendered them practically invincible — before they got suited up with the MJOLNIR Powered Assault Armor, which further enhanced their abilities.
Unfortunately, only thirty-something trainees survived the augmentation process unscathed; most of the rest died, and a handful were crippled...though some of the latter were later rehabilitated.note Though Halsey confides in her journal that there were more SPARTAN-IIs than she led the "main" class, of which John and most of the SPARTAN-IIs were part of, to believe.
There's also the SPARTAN-IIIs, vengeful kids orphaned by the Covenant who were sent on suicide missions almost right from the moment they hit prematurely-induced puberty. They lacked the exceptional genetics, MJOLNIR armor, and experience of the IIs, but mostly made up for it with less-lethal augmentations (with a roughly 100% survival rate), a poor man's version of active camouflage, and far greater numbers (300-330 per company). The newest company also received illegal drugs that further enhanced their aggression, strength, endurance, and tolerance to injury.
A handful of SPARTAN-IIIs, namely those who were good enough to meet the standards of the original SPARTAN-II program and therefore too valuable to waste on the standard S-III suicide mission, were taken out of their companies, reassigned to more elite units, and given the same MJOLNIR armor as the S-IIs. Other SPARTAN-IIIs were taken out of their companies and paired up into two-man assassination-and-sabotage teams known as Headhunters.
The predecessor to both programs was the ORION Project, later known as the SPARTAN-I program. Unlike its successors, the project used adult volunteers; unfortunately, despite the effectiveness of the ORIONs, their abilities still fell short of what was hoped for, and they tended to both physically and mentally deteriorate later in life. The only confirmed SPARTAN-I seen in the games is Sergeant Johnson.
Unlike their predecessors, the SPARTAN-IVs from Halo 4 are the first iteration of the program to successfully utilize adult volunteers (with the surviving IIs and IIIs being offered a place as well), and are all equipped with an even more advanced version of MJOLNIR (GEN2, to be precise). Due to their comparatively normal backgrounds, the IVs are far more socially-adjusted than the IIs and IIIs.
The Silencer and his brethren in Crusader, whom you never actually fight in the games. However, properly equipped, a skilled player can scythe through hordes of lesser enemies, the implications being that a squad of Silencers would be both horrifying and overwhelming in a fight.
The Boosted Children and later the Machinery Children from Super Robot Wars Original Generation are basically this - though the Boosted Children were mainly just experiments that produced some good results, the Machinery Children were the "real deal". Similiarly, the W-Numbers and Biodroids used by the Shadow Mirror and Inspectors; however, the Biodroids were mindless creations used to replace actual human losses, and the W-Numbers/-series were similarly purposed, but the W-series ended up with personalities.
W00, The Prototype of the Shadow-Mirror's W-series in the Super Robot Wars Original Generation continuity turns out to be a Human Haken Browning, if you must know. The project was switched to androids like Lamia when they realized that it takes too long for Super Soldier babies to grow up.
Final Fantasy VII (and its associated Compilation works including Crisis Core) include numerous Super Soldiers, many of which were created using Mako energy, Jenova cells, a combination of both, and/or other experiments, to produce superhuman fighters with greatly improved combat abilities, including (but certainty not limited to) enhanced physical strength and speed.
SOLDIERs, members of Shinra's elite military unit, are carefully selected humans treated with Mako energy and Jenova cells to produce superhuman combatants.
Sephiroth, Genesis, and Angeal, while generally called SOLDIERs First Class, are actually prototypes for competing Shinra research projects directed to infusing humans with Jenova's genes.
Sephiroth was created by directly infusing a developing fetus with Jenova cells (Project S, headed by Hojo).
Unlike Sephiroth, Angeal was indirectly exposed to Jenova cells because his mother Gillian was the one injected with Jenova cells before his birth, while Genesis was exposed to Jenova cells even more indirectly with his mother being treated with cells harvested from Gillian (Project G, headed by Hojo's rival Hollander).
They also had radically different results. Sephiroth was by far the strongest of the three. Eventually, he gained the ability to control the Jenova Cells perfectly....in exchange for losing all his humanity. Angeal received a weaker power boost, but inherited Jenova's ability to infuse other organisms with his cells to give them some of his power and vice versa. Genesis was a Flawed Prototype who shared Angeal's abilities but also suffered from degradation (as did his copies) — and boy does this cause problems.
Zack Fair, probably the strongest of the officially and 'conventionally' produced (i.e., non-prototype) SOLDIERs.
Cloud Strife, while never an actual member of SOLDIER, has all the physical enhancements of a SOLDIER, thanks to Hojo's sadistic experimentation after the Nibelheim Incident.
Vincent Valentine, an ex-Turk who becomes a shapeshifter with superhuman physical abilities thanks to Hojo's and Lucrecia Crescent's experiments.
From Dirge of Cerberus, Weiss, Nero, Rosso, Azul, Shelke, and the other members of Deepground, who underwent SOLDIER-type treatments as well as special individualized experimentation to develop unique powers. It was said they used Genesis as the basis, since his cells gained the ability to use Mako similar to Jenova, but without the degradation, losing your sanity (Well, okay, he did briefly lose his sanity, but for different reasons), and having a desire to smash a Meteor into the Planet to eat it for breakfast.
Final Fantasy VIII's SeeDs, who are superhumanly boosted, cast powerful magic, and able to summon deific beings to smite their enemies. These guys are apparently so badass that nine of them (in three-man teams) are expected to hold off an entire invading army, complete with artillery and killer walking robots. Twelve more candidates to become SeeDs are expected to assault and clear out an entire city of enemy soldiers.
Their single greatest advantage is actually the Guardian Forces, which allow, among other things, the casting of magic (which is insinuated as artificial and weak when used by anyone other than a Sorceress), the collection of magic, and the use of magic to increase abilities from well above average to omni-powerful. No other group specializes in junctioning magic, which is why SeeDs are so devastating. This makes a small, specialized group more than a match for most smaller armies, as long as they have specific objectives. The GF forces are capable of granting characters permanent stat boosts. If you assume the normal stat growth is "average" human stats, then it is possible endgame for SeeDs to be 3-5 times stronger, faster, etc using GF forces.
A slightly less traditional form of the Super Soldier would be the black mages from Final Fantasy IX.
Both Zidane and Kuja would fit better as Super Soldiers in this game, but it was only because unlike the rest of the Genomes, they were given souls. Makes you think what would happen if the other Genomes had gotten their souls too...
The yin to Cloud's yang, Lightning from Final Fantasy XIII. She can fly (well, actually, manipulate gravity) while machine gunning hordes of Mooks, and most amazingly do it all while protecting her modesty. And all that is before she gets her l'Cie powers.
Lightning was actually more of a Mook herself, roughly equivalent to a police sergeant, so it can be inferred that the stuff she had access to was probably standard issue.
It is revealed through the story that millions of l'Cie were created and trained to fight the ancient War of Transgression in secret bunkers. Eight of them were sufficient enough to bring down a planet, so only God knows what a full force was capable of.
The bestial enemies in the PC game Vivisector are another rare Animorphism version of this trope, being created as warriors for the main antagonist's private army. Doubly intimidating, as they have both animal and cybernetic elements to augment their fighting prowess.
Agent 47 of the Hitman series is a clone with DNA borrowed from five high-profile criminals (A German mad scientist, a Chinese Triad boss, a Colombian drug lord, a Austrian terrorist-for-hire, and a Kazakstanian arms dealer.)
The Brotherhood of Nod in the C&C series likes to experiment with Tiberium on humans (and weapons) attempting to create Super Soldiers. This is especially relevant for Renegade, which features several mutant mooks in the later levels (which tend to be immune to Tiberium weapons, or are healed by it), as well as a boss.
Which is somewhat of a parody of the original, the smallest character in the game. Havoc notes that "at least he's taller".
The Terran Ghost units in Starcraft. As well as arguably every single Protoss unit.
Most Terran units are far more heavily augmented than they appear, which is more evident in SC 2 than in the first game. The Marine in the original SC 2 trailer has multiple metallic sockets on his body and the Battlecruiser captain has a cybernetic eye.
Assuming aliens count, Protoss are the very embodiment of this trope. Zealots, the most basic protoss soldier, are 9 ft tall cybernetically enhanced warriors with decades of training, plasma shields, laser beam wolverine claws, and apparently capable of walking as fast as a motor vehicle and charging much faster than that. Oh yeah, and the can absorb as much damage as a tank (and survive a direct tank blast to the face without even losing their shields - and a couple more when their shields are down!).
Hiver members of the Warrior caste. While a worker is around the same size as a human, warrior cast hivers are far stronger and tougher, highly armored with plating, and one of the largest among any of the species in that universe. In game, this is reflected in Hiver ships being the toughest to successfully board.
Second Sight introduced two classes of super-soldier, created by the American Zener Project: the first is just an extremely well-trained marine that's been taught to create mental shields, which deflect bullets but not mind-blasts. The second- only encountered in the second-last level- are Superpowered Mooks, loyal soldiers that have been given impressive psychic abilities via implanted stem cells taken from the original Zener Children and John Vattic, the protagonist. By the end of the game, most of the two classes have either been killed in action, or never existed at all.
Caulder/Stolos' 'children' in Advance Wars: Days of Ruin. Intended not for the front ranks, but for the command room, as their ability to assemble and react on tactical information in the field, as well as their encyclopedic knowledge of warfare, is far beyond that of a normal human. Tabitha/Larissa is also implied to have physical modifications as well.
By extension of a little logic, Sami's Infantry can become this during her Super CO Power, which allows infantry of any health capture any property in a single turn. By graphical interpretation, a single, wounded infantry can on a heavily guarded opponent HQ in a single day...and win.
Fallout has the Super Mutants created by The Master as a new, superior version humanity better suited to the nuclear wasteland of the post-apocalyptic future. They didn't come out quite as expected.
Half points. The supermutants are the product of a pre-war super soldier research project. The Master just started implementing it.
Notably, the two big flaws for the Master wouldn't have been an issue for the pre-War super soldier project: almost every human back then were, effectively, pristine Vault material, so no need to go hunting for subjects that turn into smart mutants rather than dumb ones, and the fertility issue is a perk rather than a flaw if you want supersoldiers rather than a race intended to replace baseline humanity.
As seen in Fallout 3, Vault-Tec performed similar experiments on the residents of Vault 87 with a modified strain of the FEV, and the resulting Mutants turned out even dumber than their West Coast counterparts, as well as having the side effect of increasing in size with age. Only Fawkes retained his human intelligence.
Return to Castle Wolfenstein has B.J. fighting Uber Soldats at some points in the game, such as the first time in a Lab, and three at the same time near the end. Wolfenstein 3D: Spear of Destiny has the player fighting an Uber Soldat as a Mid Boss as well.
Marathon has the Battleroids, dead soldiers reanimated with cheap cybernetics. They were first used in a dispute between two small asteroid governments, in which battleroids from both sides got inside their opposing asteroids and killed pretty much everyone, after which their use was banned and they were put in stasis for safekeeping. 10 "military Mjolnir Mark IV cyborgs" were smuggled on board the Marathon, but only 9 were killed when the Tau Ceti colony was blown up. It is all but confirmed that Marathon's player character the 10th, which would explain his One-Man Army capabilities.
Prototype has Black Watches Super soldiers, soldiers infected with a modified form of the series' virus. They're bigger, stronger, and faster than the regular Mooks, they can sniff the protagonist out almost instantly even when disguised, and can easily go toe-to-toe with the opposite side's Elite Mooks, the hunters, and even the protagonist himself when in small groups.
F.E.A.R. is chock-full of Super Soldiers, including the Point Man and Paxton Fettel (products of Project Origin), Becket (product of Projects Paragon and Harbinger), and a mini-army of cloned Replica soldiers.
Witchers also fit the trope: alchemically and ritually augmented, made stronger, quicker, tougher than humans, and somewhat alienated from humanity because of it. They're also expected to be defenders against monsters normal humans can't face.
They're explicitly defined as genetically engineered (via alchemy) in a couple of places.
Jak II: Renegade sets Jak up as one of these, Wolverine-style; experimented on against his will, he later breaks free and swears revenge on the people who did it to him.
Mass Effect 2 has three. First, Commander Shepard, who was killed and then brought back from the dead, and upgraded by use of what Miranda refers to as bio-synthetic fusion. Second is Miranda, who was genetically engineered to be the perfect woman (which apparently consists of the standard super soldier package, plus good looks). Last, is Grunt, who is genetically engineered to be the perfect Krogan, or "Pure Krogan".
Also, Jack, who was engineered to become a superhuman Biotic.
Also any of the kids in the original biotic training program, until Kaiden killed the turian instructor, and the project was scrapped.
Even regular Systems Alliance Marines undergo extensive gene therapy to boost their strength, endurance and healing. On top of that they all have personal kinetic barriers and weapons with effectively unlimited ammo that fire projectiles at relativistic speeds. The only reason they're not thought of as super solders within the setting is that every other military threat out there is just as deadly.
In the Star WarsDark Forces games, the Dark Troopers, though in practice the first two generations were battledroids, the third generation could function as Powered Armor, and the resulting combo could be called Super Soldiers.
The golems of Dragon Age: Origins straddle the line between Super Soldier and Attack Animal with the reveal that they are created by entombing dwarves in stone statues and infused with molten lyrium. The golems' might gave the Dwarves a fighting chance against the Darkspawn, and losing the means to create more of them turned the tides of war against the Dwarves. Most of the few active golems remaining are kept on a leash via control rods, though a few still retain free will.
Fenris of Dragon Age II is another example, of the "angry victim seeking revenge on his creator" variety. He was originally a normal elf, but the mage who owned him as a slave had lyrium etched into his skin all over his body, an agonizingly painful process that gave him the ability to become partially insubstantial (and possibly made him stronger and more agile as well). He uses this power to resist injury...and reach into people's chests to crush their hearts.
Deus Ex: Human Revolution: Depending on play style, Adam Jensen can be either a super soldier or a super spy, or you're really good, both.
There are also the tyrants, augmented mercenaries and the only enemies you actually have to kill for them to stay down.
Both sides's grunts in Fracture fall into this category while their more elite and powerful units can almost no longer be called human.
DonPachi features the DonPachi Squadron, an elite air force unit. Deconstructed; clearing the first loop reveals that in order for prospective members to be able to take on massive enemy forces, they are ordered by their commander to slaughter the entirety of their own forces, and that this training process goes on for at least seven years.
The Abductees in It's Walky!!, especially Walky and Sal.
Grace (Shade Tail) in El Goonish Shive, who was created to fight a single individual, Damien. Subverted, however - she's a sweet, naive pacifist. Left to her own devices, she would far rather have pretend tea parties than actually fight.
Schlock Mercenary. To begin with, every human supposed to fight, including most of Tagon's Toughs, has "soldier boosts" (implants and Nanomachines) that optimize metabolism (they are mostly immune to intoxication, for one), improve reaction, strength and toughness enough that grunts can throw punches twice as strong as XX century professional boxers, without using protection or severely damaging themselves. With a Powered Armor on top of this.
Fully inertic, flight-capable, powered fullerene uniforms: about two years' salary for a grunt, assuminghe has to buy them himself.
Unlicensed soldier-boosting of the metabolism, enhancing strength, speed and reaction time: three years' salary and five in prison if you're caught.
Doyt Gyo stands out as an experiment in this area, has high-end Powered Armor and implanted genius AI acting as Mission Control and using several attack drones with great precision. Later, courtesy of the "magic cryokit", he gets more biological enhancements and interface for said AI to control the body directly — Doyt may have superhuman reaction, but his intellect is the obvious weak link.
And then the Project Laz'R'Us — experimental Nanomachines-based AI that confer virtual immortality, including an armored superhuman transitional form to revive from death, Tagon specifically calls this a "runt super-soldier".
Girl Genius has the Jägerkin, "constructs" with a rather Frankenstein's Monster meets Doctor Moreau appearance. Dressed up in the shiniest of Napoleonic uniforms (Prussian style) and really Nice Hats. Complete with silly German accent and the habit of being loud except when sneaking. Fangs, the claws, the super-strength, and the fact that they may well be immortal. They are are also "ideal soldiers" mentally. Always ready to fight, honorable (they even have a proper duel code) and extremely loyal. Also, good sport — they admire people who manage to beat them and so far we saw them hitting on ladies only after knocked out by the lady in question. Most of them are staunchly loyal to the Heterodynes and aren't exactly as monstrous as rumored to be. That doesn't stop normal people from trying to hang them, though.
Also, Airman Higgs is looking a lot like this.
And almost every Mad Scientist is building his own. (and we are talking about a world that is ruled by mad scientists)
The 'Gigglers' from the future setting of S.S.D.D probably qualifies - mass-produced clone-soldiers who feel no pain, and get injected with 'happy drugs' whenever they kill somebody... thus leading to their nickname, due to their disturbing habit of slaughtering their way through enemy forces while grinning, giggling, or laughing out loud... of course, the guys who produces them are generally considered the 'bad guys'.
There's even an example of a 'turned' giggler, Lee, joining up with a group of Core Space Marines - he is of the 'created like a Super Soldier, but raised like a normal person' variant, but still has certain... ehm... 'gigglish' tendencies.
That guy was an experiment after they managed to obtain an Anarchist Cloning Cylinder. Most clones (Gigglers) are stupid and have very little education/social conditioning, hence the implants with the happy juice; with this guy they got the process wrong. With the new systems they've been testing on him, he now has FEELING on the outside of his body, which leads to fun like "How much will it hurt if I stick this fok into my knee?"
Why are mass-produced clones being cited as an example when the protagonist of the S.S.D.F. plot arc is a Nanomachine enhanced Space Marine with Powered Armor, Healing Factor, super strength, and radio-based telepathy? What separates them from a basic Redshirt Army compared to anything from their own time? Asides from the fact that, in that plot arc, that technology (powered armor, electric telepathy, healing factor, and superstrength) is still in an experimental phase, three things: Their total inability to feel pain will allow them to continue fighting until death, as even a crippling wound won't stop them from advancing on an enemy position, whereas for an ordinary soldier, a single bullet in the hand or foot will stop all but the most well trained soldiers from continuing; their inability to feel anything other than entertainment at killing means that, unlike most ordinary soldiers, they ENJOY killing others, and will never retreat, hesitate, or show mercy, they just keep coming without even a thought of self-preservation; and the psychological aspect of having something that could be considered an insane mix of The Joker and The Terminator advancing on you, giggling all the way, with the sole intent of killing you will break all but the most disciplined unit's morale very quickly. These three together make them a force to be reckoned with on a battlefield, since, even if they're so dumb that the only tactics they understand are "go that way and kill stuff", they don't NEED anything more advanced than that, since their primary job is just to grind down enemy resistance so that the Anarchists won't lose less expendable units (like tanks, aircraft, normal soldiers, combat robots, etc.) doing the same job. After all, most "elite" soldiers require years of rigorous training before they can be half as effective at killing the enemy as a "Giggler" can be right out of the proverbial box.
This was the goal behind Hereti Corp's Aylee cloning project in Sluggy Freelance. The Oasis Project might also have similar goals.
Heroes Inc, actually highly effective the story line follows them being actual soldiers and then exploring the people's lives as superheroes.
Captain Victory of The Specialists is one of these, unfortunately it the process killed one hundred and four men to get one super soldier. Using the same serum on women had ... DifferentEffects.
Cwynhild from Cwynhild's Loom has been cybernetically enhanced, making her stronger and faster than other humans on Mars. Her reactions are also quicker, and she can interact in various ways with computer systems through an artificial right hand, including shorting them out with an electrical pulse. She can also survive being stabbed in the heart..
Genocide Man features Genocide Men, who have nanotube ceramics in their bones to make them unbreakable, artificial glands that provide combat stimulants and negate many toxins, and telomere replacement therapy to mitigate the effects of aging. Many of the genetic deviants they were designed to combat were super soldiers as well, the Ugandan deviancy comprised four-year old children with claws, slitted pupils, and ridiculously fast reflexes, they killed everyone else in Jacob Doe's squad, he only survived because he was a G-Man.
Harbourmaster's Super Soldiers are humans who were imbued with DNA-level upgrades by the Aquaans to help defeat the Yogzarthu. Interestingly, Partasah made sure that those who did receive the treatment generally fell under the heading of "Technical Pacifist"; he didn't like the idea of someone genuinelybellicose having this upgrade. Jendolyn is the main example in the series. She has no qualms about using commensurate force to protect the peace in the Tethys colony, but she'd rather not look upon violence outside of that (a bit of a nuisance when you consider her girlfriend lovesMasked Luchador films).
The Freelancers of Red vs. Blue. All of them underwent advanced training to be elite soldiers, and most were paired with an AI implanted directly into their head. Each of them also had a special armor ability (invisibility, Healing Factor, time stop). And yes, a number of them rebel.
Being heavily based on Ultimate Marvel, Marvels RPG feature several super soldiers and a lot of characters have gained powers as the effect of a super soldier program.
In the Whateley Universe, one of the theories about the growing number of mutants, especially in the US and Europe, is the heavy use of Super Soldier experiments by both the Axis and Allies during World War II; the idea is that many of the current mutants are the descendants of wartime supers. It is also explained that most of the Super Soldier experiments went badly, either resulting in hideous transformations or severe psychological disorders, which resulted in many former 'patriotic heroes' becoming super-villains in the 1950s and 1960s.
The Neo-Warriors and Neo Lords in Exo Squad. The Neosapiens themselves would count, except that they were actually designed for physical labor rather than combat. Still, they make good soldiers.
General Grievous, one of the greatest badasses in the Star Wars universe, was a cyborg. His finest display of power was shown in the animated series Star Wars: Clone Wars; at the Battle of Hypori, his first public appearance in the Clone Wars, he single-handedly defeated a team of seven Jedi, including Council members Ki-Adi Mundi and Aayla Secura. He killed four of them, and would almost certainly have killed the other three if a team of ARC troopers hadn't arrived at the last second and (somehow, without getting obliterated themselves) held him off. Grievous himself summed up this victory with a declaration of their imminent demise prior to the fight:
Grievous:"Jedi! You are surrounded, your armies decimated. Make peace with the Force now, for this is your final hour. But know that I, General Grievous, am not completely without mercy. I shall grant you a warrior's death. Prepare!!!"
The team of ARC troopers managed this because they were Super Soldiers themselves (to a much milder degree than Greivious, sure, but there were a lot more of them then there were of him). They held him at bay with impressive amounts of More Dakka.
Gorillaz's Noodle was apparently raised to be one of twenty-three Super Soldier children by a secret organisation in Japan, before having her memory erased and being FedExed to Kong.
Part of The Spectacular Spiderman's plot was the city's criminals trying to create sort of super soldiers to take on Spiderman. But more specifically a later episode is about villains fighting for the formula that was used to create the villain Rhino, in order to make an army of super soldiers.
If certain Scottish newspapers are to be believed, Joseph Stalin once commissioned Soviet biologist Ilya Ivanovich Ivanov to create a breed of half-gorillas to serve in his army. It didn't work out.note The experiment in question happened to regard a scientist attempting to breed humans and chimpanzees as a means of disproving God and ultimately the superiority of Communism. The "commission" came at a time when Stalin was throwing grants at any request that included the word "science" in it, and when he found out about it, promptly pulled the funding. This later became exaggerated by tabloids into the super soldier rumor
The Spartans of Ancient Greece attempted this process by dedicated almost their entire culture around transforming themselves into perfect soldiers The Spartan Way. In the long run, however, it led to their down fall. The number of those eligible for military service by Spartan law fell too low for them to field a proper army. Their attitudes as super soldiers also led them to being out-thought and out-maneuvered by more flexible opponents on multiple occasions.
The US Marines, or at least, that's what they'll tell you. Their reputation is hard to dispute, however. It's been said that the difference between the Marines and the other branches of the US Armed Forces is that they are a warrior cult. All of their roles can and are served by the other services in varying capacities. Oftentimes the other services can do it better because of greater manpower and resources. It should be noted that the Marines primarily fight as an assault force using a form of high mobility warfare.
It could be argued the Janissaries of the Ottoman Empire would be considered this as well. They were (usually Christian) children taken from a young age from their parents, spending pretty much their whole life in a barracks, being brutally trained to become the best soldiers that the Turks could field, and they scared the crap out of their European neighbors.
Any special operations force can be considered this; their selection is intended to pass only the strongest, hardest, smartest, etc, and their training and equipment budget, not to mention practices, are intended to be beyond that of the ordinary soldier.
Many various bodies of historic and present day military groups of various nations around the world could qualify for the trope due to their intensive selection and training. (For a sufficiently low value of 'super', anyway.)
In order to be a Navy SEAL, these are just some of the events that have to be completed: 5 days without sleep and constant physical training, a half marathon with a full combat load in a desert while stopping to perform graded tasks like shooting and weapons assembly, several dives in California water (50-65 degrees F) lasting hours. And these are easy compared to the day-to-day grind for more than a year before they get their trident. Team 6 hopefuls, after getting experience, are put through a course so challenging that about half of the veteran hand picked SEALs fail. To keep in mind, while a BUDs trainee is in far better shape than the average man, many are not exceptional athletes when they begin their training.
Skeletons of English archers during the Hundred Years War period have overdeveloped bone structures in their upper body to support the huge muscles needed to draw an English longbow of the period. In fact, until the invention of repeating firearms, the longbow itself was a far deadlier weapon, with a much better rate of fire, than muskets. However, it took ten years of practice to develop the muscles needed to draw one, whilst a man can be trained to proficiency with a musket in a week.
Italy has the Bersaglieri, a light infantry supposed to counter-charge charging cavalry and win while wearing a Nice Hat with capercaille plumes or, alternatively, a fez (originally a gift from the Zouaves, that fought on their side in Crimea). To the amazement of the world (including everyone else in Italy), they actually pulled it off at the Battle of the Chernaya, when they charged and routed a superior Russian cavalry force that was engaging and slowly defeating the French Zouaves (that were no slouch themselves, and considered one of the best infantry forces of their time). The secret of this ability is a training that includes a good dose of initiative and brings running Up to Eleven: to this date, their marching band is composed of aerophone instruments only and plays while running. You kinda understand why Benito Mussolini bragged having been one by always wearing his fez and Erwin Rommel admitted they were superior to his own troops (in his own words: "The German soldier amazed the world, but the Italian Bersagliere amazed the German soldier").