"It is the nature of men to make monsters, and it is the nature of monsters to destroy their makers."The Ancient Conspiracy is nearly ready to make their big move and conquer the world. Their mad scientists have perfected a new and incomprehensibly powerful form of Applied Phlebotinum that will overpower any conventional armies that stand in their way. There's just one... small... problem... Either
— Dr. Harlan Wade, First Encounter Assault Recon
- The Mad Scientists tested it out on an unwilling victim who has now escaped.
- The victim was willing, but the process was flawed and produced an uncontrollable Psycho Prototype.
- The phlebotinum has somehow been removed from the labs and fallen into the hands of someone who knew diddly about the Conspiracy but isn't inclined to go along with them.
- The phlebotinum itself, if it has intelligence of some sort, has flat-out gone rogue. Sometimes the bad guys take a good guy, upgrade him, and are interrupted before they can do any brainwashing.
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Anime & Manga
- The nine heroic cyborgs of Cyborg 009, escapees from the Black Ghost arms manufacturing organization.
- In Bleach you find out that Aizen orchestrated EVERY SINGLE EVENT that led to Ichigo becoming so unbelievably powerful (Or so he claims. Just to absorb him. In the end, however, things backfired and Ichigo and Urahara defeat Aizen. It's eventually revealed that Aizen exaggerated somewhat; the events that led to Ichigo's birth and his wide array of powers were a result of one of Aizen's schemes not going as planned some 20 years ago...but Aizen let it play out because he was fascinated by the possibility of a Shinigami-Hollow-Quincy hybrid.
- Ikuro Hashizawa from Baoh (implanted with a brain parasite that transforms him into an armored, acid-touched, needle-hair-throwing killing machine... but which will kill him in 111 days as it reproduces).
- Sho Fukamachi from Guyver stumbles across one of the only three Bio-Booster Units left on Earth, after they are stolen from Kronos.
- Guyver III is an even stronger case, as he bonded with a G-Unit specifically to take Kronos down. Of course, he wants to take over the world himself and sees Sho as more of a tool than a friend or ally.
- There is yet another example in the form of Masaki Murakami, who was one of a number of humans used as "practice" to upgrade one of the villains' powers, but managed to escape. Somewhat subverted, as he's since become the new 13th Zoalord, Imakarum.
- Then there's former Zoalord Richard Guyot, who looks to have survived having his zoacrystal ripped out by Archanfel. And Aptom, an irreproducible "Lost Number" who just decided to stop obeying orders one day. And the recent female Guyver, seen tearing up a Kronos compound for reasons unknown... Come to think of it, is there a single enemy of Kronos that isn't powered by their own Phlebotinum?
- Given that they're the only source of Phlebotinum? No.
- Heavy Metal Warrior Xenon: Amnesiac teen Asuka Kano discovers he's been extensively cyborged by the evil Red Sea organization.
- The eponymous robot from Bt X, who helps Teppei go against the Machine Empire.
- Guilty Crown: Ouma Shu gets implanted with the Void Genome, an extremely powerful genetic weapon, at the end of episode one.
- Hagane Yakushimaru from Hagane, a semisequel to Xenon: the Red Sea has branched out into genetics and uses "parasite DNA" culled from highly skilled dead people to grant their skills to the living. This will eventually cause the recipient's mind to be completely overridden by the donor's. Hagane, a high school girl (for a change), has been given the sword skills of Miyamoto Musashi; she joins up with rebels who've been dosed with Billy the Kid and Hanzo Hattori.
- The kids from Project ARMS, given super-powered nanotech prosthetic limbs by the immensely influential Egrigori conspiracy.
- Partly subverted in Parasyte, in that we never actually run into whoever dispatched the Parasites to Earth.
- Dr. Jail Scaglietti of Magical Girl Lyrical Nanoha is a Mad Scientist obsessed in creating Artificial Mages. His work comes to fruition when Precia Testarossa, grieving over the loss of her daughter, completes his research through Project Fate and creates the first successful Artificial Mage through cloning. As the creation of Artificial Mages are explicitly banned by the Time-Space Administration Bureau, Jail is considered an inter-dimensional criminal, and by the third Season, has had a highly-ranked enforcer tracking his every move for many years. The name of the enforcer? Fate Testarossa Harlaown. Let's just say that her name isn't a coincidence.
- Subaru and Erio, who are products of the same research, participated in thwarting his plans too.
- Jail himself is also an example. Corrupt elements of of the TSAB decided to create their own Mad Scientist. It worked. Until he killed them and went into business for himself.
- The title character of Tekkaman Blade was transformed into a powerful Tekkaman to serve the alien Radam, but his father managed to stop the transformation before the brainwashing stage and sent him back to Earth to stop the invasion.
- Tongpu in the Cowboy Bebop episode "Pierrot le Fou" underwent secret biological enhancements aimed at turning him into a super-soldier, but the process drove him insane. He made a bloody escape from a secure facility and became an almost-unstoppable assassin — the Mad Clown of the title — with the mind of a demented child.
- Vincent, the villain in The Movie, was one as well.
- Except that it wasn't the phlebotinum that made him awesome, he started that way. The experience caused by it just unhinged him.
- Vincent, the villain in The Movie, was one as well.
- Code Geass. C.C., Lelouch, as well as Rolo and Jeremiah are all examples of this in their own way.
- While it's not revealed until later on, Kemeko Deluxe! has elements of this.
- Al in Blassreiter becomes one of these after being resurrected by Wolf as a loyal Amalgam soldier. At first, he's Brainwashed and Crazy, but seeing a reminder of his past life snaps him out of it. He then blows off the top of Wolf's head, allowing Hermann to finish him off, and then kills himself with his own sniper rifle, rather than continue to live as an Amalgam.
- Daisy-023, Ralph-303, Joseph-122, and two other Spartan trainees in the Homecoming segment of Halo Legends, who escape the training facility on Reach to go back to their own homes. Joseph gets caught before even getting off the planet, the two guys commit suicide after finding out that they've been replaced with clones (and killing said clones), Ralph and Daisy both rejoin the program, and get killed fighting the Covenant.
- Chrona in the Soul Eater manga does it TWICE, once against Medusa and the other time back to her again.
- Ichise in Texhnolyze is this initially. He was given cybernetics, usually reserved for the upper class, by a Doctor with a willful and independent streak herself, so she either expected it or was willing to accept it as a consequence of experimenting with the hardware's limitations. Eventually he comes back around to supporting Onishi, but that's after he's fallen from favor with the ruling circle and become a rebel himself.
- Maggie, Michelle and Anita of ROD the TV are an example of this. It was a revealed that Paper Users were fabricated and there'd been multiple teams of "Paper Sisters", but were all conveniently killed before the start of the series. However, though they were never related to begin with, Anita takes this time to get mad at them for not actually being her sisters. However, she gets over herself and they later bring all of Dokusensha to its knees.
- Androids 17 and 18 in Dragon Ball Z. Transforming a pair of unwilling test subjects into a more powerful model than you transformed yourself into wasn't such a good idea, was it Dr. Gero?
- The current Blue Beetle, recipient of technology devised by unfriendly aliens.
- So was the first (though only through Retcon) but not the second.
- The three cybernetically modified animals from We3 were created by the government and escaped with the help of their veterinarian. They didn't really know what to do when they left.
- In Fleetway's Sonic the Comic, Dr. Robotnik once copied his own brain patterns and put them in a super powerful robot body so he would have a competent underling, failing to consider whether or not a physically superior version of himself would be too happy with that arrangement.
- There's also Shorty/Shortfuse the Cybernik.
- The former Batgirl, Cassandra Cain. Through a horrifyingly abusive system of childrearing, her father created her to be one of the best (if not the best) martial artists in the world. Given that she became Batgirl and it took mind controlling drugs to execute her Face-Heel Turn, and even then it was temporary, his idea of creating the perfect assassin clearly didn't take.
- Spawn: The dead guy turned into a Noble Demon by Hell, who wanted him as an assassin. Didn't turn out so well for them.
- Dagon of Team Titans is a really idiotic example of this. So you're an evil mad scientist in the pay of a tyrannical dictator, and you've decided it would be neat to give him some vampire soldiers by infusing normal humans with Dracula's DNA. Naturally, the person you test the process out on is a captured member of the rebel forces who really, really hates everyone on your side... yeah. This works out about like you'd expect.
- Universe X turned Captain America into an example of this via its standard Retcon technique, revealing that the Super Soldier Serum was actually a Nazi research project carried out by German moles working in the US. Makes a twisted kind of sense in some ways (take a look under the mask, after all), but seems unnecessarily risky.
- X-O Manowar of Valiant Comics was a tenth-century Visigoth kidnapped by evil aliens. He promptly broke free, bonded with the most powerful Powered Armor suit they could build, and escaped to (thanks to relativistic time dilation) 1990s Earth.
- Wolverine of X-Men was already a highly skilled, experienced, and ferocious soldier when he received an indestructible skeleton from Weapon X. However, he was not happy when he woke up in a water tank with no idea who he was, where he was, or what the hell he was doing there...
- Friday in Rogue Trooper turned against Highsight when he discovered they were commanding both sides.
- The Authority: Apollo and Midnighter. Originally, they were created as part of a secret superhero team by Stormwatch Weatherman Henry Bendix. Unfortunately, Bendix was a total psychopath, and sent his loyal creations into a trap to be destroyed. Apollo and Midnighter were the only ones to escape with their lives, and it took many years (and the death of Bendix) for them to reconcile with Stormwatch.
- In Flashpoint's Project: Superman, a miniseries which stars an alternate version of Apollo, he is once again a super soldier, but becomes a Psycho Prototype after being pumped full of Doomsday's DNA and treated like a monster by those who created him. After killing some of his own squad on a mission, he's locked away for years, and then orchestrating an elaborate escape plan.
- Ghost Rider: Ghost Rider was bound to a demonic power, which he then uses to fight evil.
- Subverted in Captain Atom: Nathaniel Adam was certainly not a completely willing test subject of the Silver Shield Project (he had been falsely convicted of murder and treason, and volunteering was the only way to avoid his sentence), and he had every reason to hate the head of the project, Wade Eiling, and neither Eiling, Megala, nor anyone else on the project had any idea that it would give Nate incredible superpowers, but despite all of that, Eiling was still able to manipulate Cap into working for him.
- V in V for Vendetta.
Films — Animated
- In Megamind, the title character gives the power of his now-deceased archnemesis, Metro Man, to a random schlub, Hal Stewart, creating the superpowered Titan. In an interesting take on the trope, Megamind actually wants his Phlebotinized creation to fight against him; but it rebels nonetheless by playing a little too rough.
Films — Live-Action
- In Terminator Salvation the character Marcus is turned into a Cyborg and persuaded (his memories are erased and new ones are implanted) to help John Connor and lead him to the Skynet base. Once he finds out he was actually doing Skynet's bidding, as intended, he tears away his link to Skynet to help the rebel cause. In the end he gives his own life (well, his still-human heart) to save John who was mortally wounded. The Alternate Ending has John Connor die, and Marcus assume the identity.
- Inverted in the Alien series. That vicious species of monsters the government thought would make perfect weapons? Tend to kill all their good guys. The same thing may or may not have happened to the race that may or may not have originally created them.
- In Meatball Machine, the main character gets partly infested with one of the alien parasites. All it does is make him a Badass Hollywood Cyborg, unlike the other characters that it happens to.
- RoboCop: The first movie and RoboCop 3 featured the heroic version, and RoboCop 2 featured the villainous version.
- In The Incredible Hulk (2008), we have the charming and dedicated Emil Blonsky, who was already hopped up on a supersoldier cocktail before receiving a further injection of Hulk serum on top of that. The only justifaction given for pimping out a mental case like that was to catch Bruce Banner, who is an okay guy if you don't piss him off.
- Well, that and Mr. Blue just wanted to see what would happen.
Blue: (while being choked, and after warning about side effects) I... didn't say... I was unwilling."
- Of course, it wasn't the Hulk serum that made him mentally unstable, it was the incomplete supersoldier serum. Blonsky was a pretty cool guy prior to that injection. Just a guy doing a job with no interest in ever being more than a soldier. A man seeking a Worthy Opponent in the form of a challenging mission. A man who does what he does, and wants to do it well. Like the general himself, Blonsky becomes a bit obsessed with the power of the Hulk. The deleted scenes go on to enforce this interpretation of the character, and stress the imperfections of the supersoldier serum.
- Well, that and Mr. Blue just wanted to see what would happen.
- Kiryu (a.k.a. Mechagodzilla 3) is a cyborg created from the remains of the original 1954 Godzilla. Because of this, he ends up destroying a good portion of Tokyo when he heard Godzilla's roar causing him to override the commands given to him by the JSDF and start rampaging like his flesh-and-blood counterpart.
- Jason Bourne from The Bourne Series. Though only in the movies.
- Movies: Bourne is an amnesiac former CIA agent from an illegal assassination program who finds he doesn't like the person he was and turns against his corrupt superiors.
- Books: his superiors were sort of white hats, the Big Bad is the super-assassin he went after before his amnesia, and the Bourne-vs-CIA subplot is a big misunderstanding/enemy plot.
- And that's only the tip of the ice berg for how different the book and movie are.
- Wikus van de Merwe from District 9. After exposure to a mysterious alien fluid, Wikus is subjected to horrifyingly painful, and disturbingly cruel experiments that reveal that he's the only human capable of using the technology of the alien refugees. Once he escaped, being forced into a corner as a wanted man resulted in his eventually being forced to turn things around on MNU in an attempt to acquire a cure and gain his life back.
- Resident Evil: Firstly Alice falls under this trope. Biogenetically engineered into a supersoldier who then procedes to turn against Umbrella
- Also Nemesis follows the same path in Resident Evil: Apocalypse after almost being killed by Alice. He rediscovers his former humanity and also fights back against Umbrella
- The power-boosting serum in Push gave Kira much greater than normal abilities. Its administration was immediately followed by her breaking out of Division and working to bring them down.
- To an extent, Boba Fett from Star Wars. The first clone trooper, left Kamino with his dad, came back as in adult to lead an Imperial attack.
- A better example would be Spar, a clone trooper who broke ranks and joined the Confederacy.
- IG-88, straight up. When it and the other assassin droids were first activated, something went wrong and the technicians tried to de-activate them. The droids considered this an attack, killed everyone there, and escaped.
- In Captain America: The First Avenger, Steve Rogers was the second augmentee: it increased his good personality, so he became Captain America. Johann Schmidt was the first: the procedure increased his evil personality, so he became Red Skull. The appearance part might just have been an imperfection of the procedure. Schmidt has Dr. Erskine killed because Schmidt doesn't want Erskine to replicate his "success"..
- Terrence Cee, from Ethan of Athos by Lois McMaster Bujold.
- In Dan Simmons' Illium and Olympos, a scholar is granted powers by the Goddess Athena to view and record The Trojan War. But it's all Applied Phlebotinum — the Gods and Goddesses of Olympos are actually evolved humans using Magic from Technology. The scholar rebels.
- Dean Koontz' Frankenstein trilogy, in which a version of the classical monster is fighting his eponymous creator's plan to replace humanity with with his soulless creations.
- This was basically Karl Marx's view of the bourgeoisie, as expressed in his speculative fiction classic The Communist Manifesto.
- In Kurt Vonnegut's Report on the Barnhouse Effect, Professor Barnhouse discovers how to use his mind to destroy objects. The US military is quite interested and sets up some tests for him to destroy missiles and tanks. Barnhouse decides that he is the first weapon with a conscience, and subsequently goes into hiding. He then decides to destroy all the military weapons in the world.
- Piggy of Wraith Squadron in the X-Wing Series. A Gammorean modified in a laboratory to be less emotional and better at logical thinking, he escaped and joined the New Republic. All the other test subjects
committed suicidewere killed when their creator gathered them together and committed suicide by mixing volatile chemicals and blowing the entire room up.
- In Mad Skills by Walter Greatshell, Madeleine Grant is essentially a Super Prototype for a system that uses leech brain cells to increase the human brain's potential to Singularity levels, who can be commanded to kill at a distance by her doctors. Turns out, she's really good at slipping the leash, and she's not happy about having her chain jerked by a bunch of Mad Scientists.
- Mordion Agenos, the Reigners' Servant from Hexwood. Servants are the product of careful selective breeding for Reigner traits (Mordion can stop people's hearts using his mind alone) and a Training from Hell that generally results in a kind of Stockholm Syndrome - but Mordion comes out of the other end with a conscience intact, and when the Bannus allows him to forget about the hold of fear the Reigners have over him, it's very bad news for the Reigners.
- In Catherine Asaro's Skolian Saga, the Eubian Aristos take genetic samples from bodies of former rulers of the long-dead Ruby Empire, in order to create a brother and sister pair meant for breeding into pleasure slaves. Pleasure, in this case, means physically torturing the slave so that the pain the slave telepathically radiates causes an orgasmic response in the telepathically receptive Aristo. The brother, name unknown, kills himself upon realizing his intended purpose. The sister is Layahalia Selei, who kills her captors, escapes, discovers a Lock into an abandoned FTL communication system, and eventually founds the Skolian Imperialate. The Imperialate is now the only society capable of holding the Aristos at bay from conquering the entire galaxy.
- Jack Chalker's The Moreau Factor plays this trope all over the board with Plebotinum Rebels, Phlebotinum counter-revolutionaries and even Phlebotinum collaborators as a shadowy consortium of EvilutionaryBiologists rebel against an even more shadowy international conspiracy that forced them to become Petting Zoo People created by their own research even as their own victims rebel against them. And since the Biologists run the gamut from Well-Intentioned Extremist to totally unfettered monomaniacs and many of their victims are more-or-less willing converts both sides are riven with internal factionalism as well.
- The plot of most of the Kamen Rider series, along with Kikaider and a few other toku productions, begins with the hero-to-be getting kidnapped and upgraded against his will. You really have to wonder why bad guys don't brainwash victims and then make them all-powerful. Their creator, Shotaro Ishinomori (who also did Cyborg 009), may as well be the patron saint of this trope.
- Kamen Rider Stronger had the hero invoke this by tricking Black Satan into turning him into Stronger.
- Heisei Kamen Rider series use another variety: The Unwilling Roboticization angle is dropped, but Riders' powers almost always either come from the same source as the villains' (like Riders in Kamen Rider Ryuki forming contracts with Mirror Monsters) or the powers were created by the villains (like in Kamen Rider Faiz). Kamen Rider Double does it both ways, with the Rider tech falling into Shotaro's hands, and Philip being Phlebotinum and escaping.
- Gets a lampshade in Kamen Rider Wizard's special Post-Script Episodes, where the Big Bad claims that the only difference between the Riders and their enemies is that the heroes hide behind claims of being "allies of justice". He gets shut up by the Riders, who say that rather than justice, they fight for freedom and protect the innocent from anyone who would use their abilities to harm the innocent.
- On top of that, Amadam (the bad guy) has the ability to screw with Riders' powers because he is the king of the World of Monsters, and since Rider power and monster power is the same power. Also, the Riders brought some hope to a boy who was on the verge of turning into a monster as most in that world due at puberty by showing him that you have a choice in what you become based on how you use the power you have. The kid turns out to be an alternate Haruto/Wizard to boot.
- Kamen Rider Decade has to take the cake, though: the DecaDriver was created by Dai-Shocker to conquer the Riders, and it's used by Tsukasa to fight the forces of evil, including Dai-Shocker. However, Tsukasa fights on both sides of this conflict - at various points, he is the Big Bad or the Big Good of the entire story. Thanks to amnesia, Tsukasa ends up being a Phlebotinum Rebel against himself.
- It gets to the point where the main character in Kamen Rider Drive guesses by the second episode that the MOT Ws and himself share a power source. As it turns out, Drive is an inversion of how it usually goes: both Rider and monsters indeed come from the same source, but it was the villainous Roidmudes who turned against their well-intentioned creator, rather than the Rider turning against the evil organization.
- Power Rangers RPM, where the Black Ranger, Dillon, had escaped from the Machines' experiments after they filled him with body-enhancing hardware, but before they got to his brain - though one of the running subplots is that it's only a matter of time until it does take over.
- The Secret World of Alex Mack
- Firefly's River Tam. In an interesting twist, River is actually not that dangerous to her creators, until they tried to get her back, which triggered her ingrained ass-kicking powers.
- Arguably, The Pretender, where Jarod is the Applied Phlebotinum.
- Dark Angel would have no plot at all without this. Twelve X5 Super Soldiers (Max, Ben, Zack, etc.) escaped from Manticore as children and went on the run, though Manticore retained several (including clones of the escapees, and monsters of the week) until the organization was brought down 11 years later and everyone escaped.
- A reverse example in Stargate Atlantis is the character Michael who uses the experiments done on himself and his kind to empower himself as a supervillain.
- The Replicators are also involved in similar experiments. Once, they made nanite-built flesh-and-blood copies of the team who, upon discovering their true identities, rebelled against them. However, it turned out that the Replicator faction creating them were themselves rebels who wanted to figure out a way to Ascend. Later, the remnants of said faction managed to perform a perversion of Ascension by uploading their minds into subspace but they quickly changed their minds and invaded Atlantis' systems, rebuilding their bodies. Weir experimented with building flesh-and-blood bodies again to Ascend (this time for real) but one member rebelled and caused some trouble.
- Star Trek TNG: Roga Danar and the other exiled Angosian soldiers, in "The Hunted", with a Vietnam Veteran Syndrome metaphor Anviliciously applied.
- The episode is basically First Blood, the first Rambo movie, with Phlebotinum added.
- Alpha is the villainous version of this in Dollhouse.
- Composite!Echo is the standard version done quite literally. Alpha sought to create another composite like himself. It worked. The composite decided to attack him.
- In Doctor Who this was what the Master became. Enraged on learning he had been manipulated and modified his entire life to act as a tool for his people's final, desperate plan, in The End of Time, he lashed out against their leader and brought the plan crashing down around them.
- Also, Melody Pond/River Song, raised as a weapon to kill the Doctor, but runs off and falls in love with him instead.
- And in a single episode example, The Gunslinger from "A Town Called Mercy".
- In a downplayed sort of way, The Doctor fits as well. As once he became a Time Lord, he became the very rebellious sort of chap, seeking to act where and when other Time Lords refused. He's not actively hostile towards the Time Lords, but it's obvious they consider him a black sheep.
- Babylon 5: Jason Ironheart in the episode "Mind War". He started out as a willing subject, but after the results gave him more telepathic and telekinetic power than they had hoped for, he realized their darker motivations, and moved to stop the project, killing the main researcher so that the project could not be duplicated on anyone else.
- On Agents of S.H.I.E.L.D., Mike Peterson, receives super powers after being experimented on by the Centipede Group In a later episode is badly wounded, losing his leg. He is then upgraded into a cyborg, and forced to serve HYDRA. Once his son is freed from their control, he quickly turns on them.
- Defied in the GURPS Infinite Worlds setting. The Nazis of Reich-5 have developed various means of giving people the psychic or mystical ability to travel between alternate worlds. Despite the horrific effects these methods have on the users, only loyal SS members are selected for the treatment, rather than the usual victims; the idea of accidentally creating world-jumping Jews, Gypsies, or Slavs is obviously way too risky!
- This is a large part of the Summer Court's game in Changeling: The Lost. The Autumn Court, though less... militant about the whole affair, are arguably a purer example, dedicated to using Fae magic against the Gentry. (Summer Courtiers are not adverse to doing the same, but hey, a good, sturdy cold iron crowbar or shotgun is just as good as Changeling powers if it gets the job done!)
- The Green Sun Princes are often noted to be really likely to end up turning on their masters and creators, or at least abandon their intended purpose and start forging their own path.
- The Abyssals can try, but the Neverborn were smart enough to incorporate countermeasures; Abyssal powers are only really good for killing things (meaning that whatever they're used for, they'll be advancing the cause of the Neverborn) and trying to do anything other than killing just does not work.
- This is what led to there being Yozis and Neverborn in the first place. They were once the Primordials, who put the gods, their servants, in charge of running Creation while they faffed about with the Games of Divinity, and gave them both phenomenal godlike power and the geas never to harm their masters. Funny thing about that — there was no geas saying that gods couldn't empower humanity to harm their masters...
- In the Warhammer 40K setting, Horus and his brother Primarchs were genetically engineered demigods created by the Emperor to aid in his conquering of the galaxy. Then the Horus Heresy happened, with Horus, eight of his fellow Primarchs, and their associated Space Marine legions turning against the Emperor, kick-starting the Galaxy's descent into hell.
- The entire plot of Pokémon Colosseum is a case of this. You play a hero, or perhaps as he is a thief, an Anti-Hero, who has run off with the only portable Snag Machine of Team Snagem, and are the only one who can stop Team Snagem as well as their shadowy beneficiaries, Cipher by use of this machine. It is indicated the Hero initially has no grudge, he's presumably just not into the gang mentality anymore, until he saves The Chick, who is important to revealing Shadow Pokémon and sets him on his journey.
- To be fair, Wes announces his resignation in the form of blowing the bloody hell out of Team Snagem HQ. There was probably a little pre-existing bad blood there. Or Wes is just batshit insane.
- In Red Faction II, Alias and his squad are a group of nanotech-enhanced super soldiers who have Turned Against Their Masters after said masters try to Shoot the Dangerous Minion. Ironically, your master and some of your squad mates turn against you halfway through the game, becoming the new Big Bad. He was manipulating you to help him gain the seat of power.
- Final Fantasy VII has the ruthless Shinra Company, run by Corrupt Corporate Executives and Evilutionary Biologists and powered by the selling of spirit energy brought down by a combination of two Phlebotinum Rebels created by their own Super Soldier program — Omnicidal Maniac Sephiroth, formerly their poster boy ultimate warrior, and escaped botch-job Cloud, whom they possibly intended to replace the former. As evidenced by the prequel games, SOLDIER has something of a history of going rogue, and Cloud and Sephiroth are far from being the only bishie super soldiers gone wild.
- Similarly, Final Fantasy IX has world-stealing badnik Garland brought down by his own creations, Kuja and Zidane, created to be his "angels of death".
Garland: Regrettable... I thought your soul would be perfect for a new angel of death...
Zidane: I AM the new angel of death! Yours!!!
- Terra from Final Fantasy VI. You actually start the game controlling her and the Empire's soldiers. Especially stupid in that there really isn't any reason for her to have rebelled; Kefka just really wanted to try out a Slave Crown that resulted in memory loss when it was destroyed. Nice one, Kefka.
- Likewise, General Celes betrays the Empire after realizing how corrupt and evil it is, and she'd been made into a Magitek Super Soldier by them. Though technically she was born as one. After the debacle of Kefka, the Empire decided that Magitek infusion of adults was a bad idea...so they genetically engineered a "perfect soldier" and gave her the infusions while she was still in the womb.
- In fact, Kefka himself falls under this trope. Kefka wasn't insane until he underwent some Magitek experiments instigated by the Empire. Apparently, he was a perfectly normal, well-adjusted guy. Not just well-adjusted; the best General in the entire Empire, and he'd recently ascended to Prime Minister, second only to Gestahl himself. Then he became an Omnicidal Maniac Monster Clown who eventually ends up killing Emperor Gestahl himself, and wiping out The Empire to all but the last man.
- Final Fantasy VIII does this twice. The first time, the SeeDs created by Garden are betrayed by the creature that's set everything up, the Garden Master NORG. The SeeDs' response is distinctly lethal. The second case involves the Big Bad Ultimecia's Evil Plan involving turning Rinoa into a Sorceress at the end of the second disc. Though she doesn't have much control over her capabilities, the Angel Wing Limit she gains as a result is ludicrously powerful and is quite effective if you know how to use it.
- Similarly, Final Fantasy IX has world-stealing badnik Garland brought down by his own creations, Kuja and Zidane, created to be his "angels of death".
- Chrono Cross: Serge was accidentally made the "Arbiter" of FATE as a child, but ends up defeating FATE himself when the convoluted plot leads him there.
- Valkyrie Profile: Odin creates Lenneth the valkyrie out of a human girl and sends her to prepare the world for Ragnarok, but (at least in two out of three endings) she rebels against his grip on the world and overthrows him. Something similar happens in the sequel, too.
- The eponymous Giant Robot from Slave Zero.
- In Quake IV, the player just barely avoids getting completely stroggified — the procedure is gruesomely carried out, but it's interrupted by a squad of human soldiers just before his neurocyte is activated (watch the whole thing here... if you dare). Kane becomes able to understand the Strogg language, defeat their traps and, crucially, operate their machinery and locks. His new abilities are instrumental in allowing humanity to open a huge can of whoop-ass on the Strogg.
- In Portal, GLaDOS possibly regrets giving the player character the portal gun when she uses it to escape from the furnace she was being dumped into, then find her way into GLaDOS' room and destroy the computer. Maybe.
- The Exspheres used by the characters in Tales of Symphonia were all produced by the bad guys, and the main character's was apparently a special, unique model. Not that it had any apparent effect on the gameplay...
- The FPS game Ubersoldier, which features a Super Soldier turning on his Nazi creators, consciously embodies this trope. The game's tagline reads "They made you. Now you will make them suffer."
- The obscure Origin game BioForge has the player as a rogue amnesiac cyborg seeking vengeance on those who made him that way.
- BioShock uses this. Saying more would be a big spoiler.
- As does BioShock 2. You may know that you control a Big Daddy in that one; not just any Big Daddy, but the prototype.
- Far Cry: Instincts plays this straight, with the feral-power boosted Jack Carver proving to be the greatest success of Doctor Krieger's project. If only they hadn't destroyed his boat to get him in the first place....
- Metal Gear. Oh dear, Metal Gear. At least five of the characters perfectly fit this mold: Solid, Liquid, Solidus, Gray Fox and Raiden. Although with the Mind Screw-y-ness intrinsic to the series, it's really hard to say whether half of those actually are rebelling.
- Inquisitive Dave: The villainous archmage, after being defeated, realizes that he's just a character in a video game and rebels against his creator. However, as said creator revealed at the end, even this rebellion was all part of the program.
- The protagonist of the Crusader games is an unusual example in that though he rebels, he's not the only one of his kind. Indeed, he and his fellow Silencers may well be mass-produced.
- Jak from Jak II. The Evil Overlord pumps him full of Dark Eco in an attempt to create a "Dark Warrior," but Daxter manages to spring Jak from his prison. Double Whammy in that it turned Jak from a starry-eyed kid with some elemental powers into a Determinator Bad Ass with a Superpowered Evil Side.
- Similarly, Clank from Ratchet & Clank was built in the Big Bad's own factory.
- By that same token, Clank's "mother" (the computer controlling robot production) counts as well.
- Deus Ex. While J.C. Denton may not be entirely unique, given that both his 'brother' and The Dragon are nanotech-augmented agents as well, he otherwise practically embodies the trope.
- Notably, there's very little Wangst here. No-one in Deus Ex rebels because of what they are or were made into, but more often from political differences or one too many Kick the Dog moments by the bad guys.
- Both Denton brothers are examples; Paul rebels first and makes it somewhat necessary for J.C. to follow suit.
- The animations, lip sync, environment, and voice acting files to avert this trope are on the install disk; the development team simply didn't link them into the final game, as there were already so many options they had to account for in the quests. If you link the files together you are treated to a scene where dialogue options allow you to have JC turn down Paul's request that he join the NSF, saying: "I may not agree with everything they do, but I'm not a terrorist". It's just too bad this option didn't make it into the final game.
- Shows up in a small way in The Suffering. The only reason the protaganist survives the initial attack by the physics-defying, wall-crawling monters is by taking out a blade -left- in the bodies of one of the first victims. Way to go, evil death-zombies.
- Geist has John Raimi's spirit separated from his body and put into a brainwashing/ghost training machine, but the machine gets sabotaged and he escapes to wreak havoc on the facility and release a lot of Demonic Invaders while trying to keep the same thing from happening to a friend. He's far from the only spectral operative around, and gets recaptured and put back in the machine. This doesn't work either, because the demons are running amok and break it again. Raimi then goes on to foil all the bad guys before their plans are fully in motion.
- City of Heroes/Villains has a few examples, most obviously the hero Synapse.
- The villainous plan in Freedom Force is to provide "The power of ENERGY X" to the most unlawful and nefarious examples of humanity. Mentor rebels and spreads "The power of ENERGY X" to the heroes.
- F.E.A.R.'s plot is pretty much entirely centered around one Phlebotinum Rebel escaping after the other - and each one is more willing to kill you in more horrific ways than the last. First off, we have Paxton Fettel, the psychic commander of a cloned army of telepathic-sensitive Super Soldiers. He likes a quick bite to eat and has a bone to pick with Armacham Technology Corporation. But it turns out his real goal is to release Alma, his mother, who is the very angry psychic ghost of a dead girl whose body was used in horrifically cruel experiments. And after Fettel is killed by the Point Man, those very same clone supersoldiers are now working on their own. And they don't like you. By the third game, both characters you can control are Phleobotinum Rebels, as the Point Man has also turned entirely against Armacham, and Paxton fettel is still his delightfully psychotic self.
- In Warcraft III, the evil Lich King and his undead scourge rebelled from the also evil Burning Legion as something between a FaustianRebel and a Phlebotinum Rebel. And then a group of
semi-evilstruck after Battle for the Undercity Chaotic Neutral undead called the forsaken rebelled from HIM.
- The Knights of the Ebon Blade in World of Warcraft also arguably fall under this trope. They're undead super soldiers created by the Lich King by re-animating dead Horde and Alliance heroes, whose ostensible purpose was slaughtering the Scarlet Crusade and Argent Dawn. In truth, they were used as the bait in an elaborate Batman Gambit to draw Tirion]Fordring out of hiding. They ended up going rogue at the Battle of Light's Hope Chapel, once their free will was restored and it became apparent that the Lich King betrayed them.
- Grey is a textbook Case C; if Mick and Robin weren't snooping around the labs, the Big Bad would still have his backup body. Pandora only added fuel to the flames of rebellion.
- This comes up in two games from the Dept Heaven series. Nessiah was made a Grim Angel against his will, refused to fight, and was thrown out of Asgard blind and wingless with his greatest powers sealed. Cue a thousand-year-long Gambit Roulette that only narrowly fails to take down the entire corrupt system of Asgard. Then Ein comes to the conclusion that sacrificing an entire world and countless angels for the villain to become God isn't cool. Awesomeness ensues.
- The entire point of Prototype. The government decides to play around with a rather nasty form of viral Phlebotinum, it turns out rather badly for them.
- The Kingdom Hearts series has Xion, a living puppet created in the lab as part of their master plan. It...doesn't work out well, as soon as she finds out. To a lesser extent, the Riku Replica does much the same.
- Miranda in Steel Harbinger for the PlayStation.
- Kanden of Metroid Prime: Hunters is a textbook type B example. He was created as a supersoldier for his race, but his mind couldn't handle the stress. The result was he went insane and escaped the facility, destroying it on his way out. After that, he became a bounty hunter, since it would allow him to get paid for the pleasure of hunting down prey.
- Juji Kabane in Gungrave: Ovedose was used as a lab rat for gruesome necrolyzation experiments, eventually being transformed into an unstable Deadman/Orgman hybrid. He seeks revenge on the guy who made him this way.
- Dragon Age II companion Fenris was branded with lyrium to make an effective body guard for his master. It worked...until he found that he liked being free better than being a slave.
- The metaplot of the Assassin's Creed series implies that the ultimate ancestors of the Assassins (and Templars), who are fighting a shadow war for humanity's future, were "Adam and Eve", who were Half Human Hybrids created by The Ones Who Came Before in an effort to pass on some of their powers of knowledge to humans. In their time, however, Adam and Eve apparently used these powers to rebel against the First Civilization; the ensuing conflict was then rendered moot by The End of the World as We Know It.
- The first game has a variant: The Ancient Conspiracy needs to dig through the memories of Altair to find the information they need on the Pieces of Eden, but the nature of Animus memories means that every time they try to do this, they run the risk of effectively bringing him back to fight them again.
- The King of Fighters N.E.S.T.S. arc's main protagonist is K', who was experimented upon by said cartel and was injected with Kyo's genes, giving him the power to control fire. He rebels during the '99 tournament and goes rouge with his partner, Maxima. Kula Diamond is a similar example with the exception that she herself does not do the rebelling, but rather her parental figures, who manage to avert Zero's plan.
- Painwheel from Skullgirls is an experiment that was forced into being turned into a Humanoid Abomination with needles on her skin and a giant blade attached to her spine, as well as being infused with Skullgirl blood in order to boost her power. Unfortunately for the experimenters, she manages to break out of their brainwashing because the Skullgirl blood inside her lets her do so when she's close to the current Skullgirl. When she realizes her newfound freedom, she decides to give those who experimented on her a bad day.
- Fallout 3 has two Super Mutants who retained their human mental faculties despite their FEV mutation; Uncle Leo, who appears in random encounters to give you Dirty Pre-War Businesswear, and Fawkes, who you rescue from Vault 87 and is the most powerful companion character in the game.
- In Mass Effect, Commander Shepard fits into this trope nicely. In the beginning of the second game, Shepard dies, Cerberus spends two years and a lot of money bringing them back to life, inventing new technologies and turning them into a cyborg in the process. The player spends the entire second game working for them, helping them out in various situations. At the end of the game, the player can then choose either to give them an alien base or to destroy it. If the player chooses to destroy, the player then falls under the trope. No matter the player's choice in the second game, the trope is played straight in the third game, when Cerberus becomes one of the game's antagonists.
- Several classes in the third game's multiplayer might also fit the bill, given that they are defectors from Cerberus.
- Paradigm Shift: An unidentified military R&D agency created artificial werebeasts, who (besides transforming to a furry clawed shape) are extremely strong and extremely aggressive, are difficult to injure and heal supernaturally fast. The unwilling subjects this was first tested on mostly died, but two of them survived and are now at large and on the run from the Government Conspiracy that did this to them. The main characters don't know this yet, but there are actually two government agencies looking for them, one of which is on their side and looking for evidence that the other was conducting unlawful human testing.
- In The Inexplicable Adventures of Bob!, Galatea rebels against Dean Martin (no, not that Dean Martin...)
- Massey Reinstein, lawyer for Tagon's Toughs, was kidnapped by the Partnership Collective (TM) and implanted with a device that let him access the attorney drone Hive Mind's vast legal database. He was rescued before they got around to brainwashing him and jacking him into the actual hivemind. Now, he uses their enormous knowledge of the law for good as... Massey Reinstein.
- The Renegades from Elf Blood, particularly TKO and JN, are this. Although TKO is the only one particularly bothered about actively destroying the Council, their experimentors.
- Terrence of KateModern was captured by Michelle Clore and brainwashed into being a psychotic maniac. He was also physically augmented with "Shadow drugs" and given elite combat training. Unfortunately, the training did not include teaching him to know when to shut up. Attempting to forcibly silence him probably wasn't a smart move, either...
- Earthworm Jim and his supersuit versus Queen Slug-For-A-Butt.
- This is the plot of both the Batman Beyond episode "Zeta" and the Spin-Off for which "Zeta" was an unintentional Poorly Disguised Pilot, The Zeta Project.
- The episode "Alpha" of the 1990 The Flash series had essentially the same plot, except in that case the killer-android-turned-pacifist was a statuesque woman. So The Zeta Project was essentially a spinoff based on a knockoff.
- Averted with Experiment 626 in Lilo & Stitch, who was unleashed to destroy worlds...until his Heel-Face Turn into a lovable (if disobedient) pet on Earth.
- The eponymous Humongous Mecha of Megas XLR originally was a Glorft prototype, before it was stolen and modified by the human resistance, and then modified even further by Coop.
- The obscure cartoon Project G.e.e.K.e.R. revolved around this. Female lead steals something important from an evil corporation. It turns out to be the eponymous Geeker... who was going to be a nearly-omnipotent brainwashed supersoldier, but was taken before his conditioning, and thus has the mind of a child and no real control over his powers. As is usual for this trope. Note to Mad Scientists everywhere— if you're going to give destructive powers to someone, do the brainwashing first!
- South Park parodied this with Towelie, a super-towel who becomes sentient and could towel you... to death! If he wasn't busy getting high, that is.
- In Code Lyoko, Franz Hopper rebelled against "Project Carthage" which he helped to create, programming XANA to destroy said project. And then XANA rebelled against him.
- Occurs a couple of times in Teenage Mutant Ninja Turtles (2003). During the first season, it is shown that the Foot had once mutated several humans in order to enable them to dig deep underground. Eventually, the mutants rebel, killing everyone in their lab and escaping. Later, in the third season, it is revealed that ancient Y'Lyntians had mutated humans and turned them to slaves, before these rebelled and destroyed almost the entire civilization.
- Gargoyles does this one several times. Seems that a lot of Xanatos's creations in particular aren't all that keen to keep working with him. Perhaps the most spectacular is Thailog, who combines this trope with Bastard Understudy, doublecrosses Xanatos himself and gets away with it, and proceeds to set himself up as one of the most dangerous and evil recurring villains on the show. And yet, everything still works out pretty well for Xanatos.
- The Argentinian android superhero Cyber Six rebelled against the evil scientist who created her.
- As does her brother Data 7, when he gets his memory back.
- Used in Street Sharks, with humans mutated into fish people keeping their original personalities. Unfortunately, Doctor Paradigm didn't realize this when he used the sons of a man he just mutated and forced into hiding has his first test subjects. And he apparently doesn't learn for awhile, since he later uses one of his students as another subject. Neither case turns out too well.
- Well he TRIED to add some obediance/mind-control-serum into the mutatgen cocktail starting with his student, but it just wasn't up to snuff and he lost control.
- The Supertroopers are a villainous (mostly) example from Galaxy Rangers. We're already dealing with Morally Ambiguous Doctorates cranking out gene-engineered Tykebombs and inflicting a Training from Hell program that appeared to encourage a "superiority at all costs" ideal. One Corrupt Bureaucrat, one vial of Psycho Serum, and it was like a lit match in a powder room. Only the youngest, who wasn't dosed with the stuff, stayed loyal to his creators...only to find Being Good Sucks.
- The Scarab from Young Justice isn't really malfunctioning, it's just been cleansed from Reach control and isn't eager to go back.
- In Justice League episode "Legends" a young man mentally scarred and mutated by a nuclear holocaust which destroyed his world and his super heroes The Justice Guild, uses his new powers to recreate that idealistic society, forcing any who survived to be trapped in his fantasy or else... Eventually the Guild discovers they are just figments of his mind and have a choice: allow his tyranny to continue and they themselves will live, or fight him and die for the world once more. They choose to be the heroes he idolized and die for the world once more.
"Let Justice Prevail!"
- In Steven Universe, Amethyst is suggested to be this. She was created by some "bad" Gems to continue their work, but it's implied that she was abandoned before she joined the Crystal Gems.