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- The heroes of the Lyrical Nanoha franchise tend to collect artificially created or illegally-experimented-on people and adopt them into one of several overlapping "families". These include roughly half of the "Numbers" combat cyborgs in Magical Girl Lyrical Nanoha Striker S; Fate and Erio are both from the same cloning project; Signum, Shamal, Vita, and Zafira were all programmed murder machines until recently; Subaru and Ginga are precursors to the aforementioned Numbers; Agito only remembers back to her time spent in an unethical lab, being tested to death; and Vivio is a clone bioweapon. So far, that's no fewer than 18 project refugees all living in one big extended family.
- Mobile Suit Gundam 00:
- Allelujah and the Human Reform League supersoldier test subjects are implied to have tried to be this. Their very short-lived attempt doesn't work out very well.
- From the second season on, Celestial Being seems to have become this. It's explicitly stated that Feldt, at least, considers the group her family, but then she was literally born and raised in Celestial Being (her parents were both Gundam Meisters who died before CB went public).
- Fullmetal Alchemist The Homunculi are a mixed bag. Lust showed affection for Gluttony like one would for a "pet" and he was likewise fond of her, and Wrath looked upon Sloth as a mother-figure. However, Greed had severed all ties, Pride was more of a boss, and Sloth was an assistant. In the manga, the other homonculi are outright terrified of Pride, and Sloth is really just a slave. The entity they call "father" seems to be called as such more out of fear than affection.
- Gluttony is so upset by Lust's death that he goes Ax-Crazy when he realizes he's in the same room with her killer. On the flip side, Pride thinks nothing of devouring Gluttony when it's convenient for him.
- In the 2003 anime version, Wrath and Sloth's relationship fits this as noted above. Likewise, Gluttony seems to show this in the 2003 anime, in which he is visibly distressed about the knowledge that Lust has died. He shuts down, to the point where Dante has to remove his mind so he will finalize the Philosopher's Stone that Alphonse's body has become. He is so distressed that Gluttony loses his appetite!
- The Schiff in Blood+.
- The cyborg characters in Cyborg 009.
- It could be argued that this applies to the Soul Society in Bleach. They're not artificial, but they pretty much have no way to find actual relatives (except for Rukia's sister), so end up adopting each other as families.
- This is actually stated by Yuichi when he talks to Chad upon Ichigo and his group arriving in the Soul Society.
- As stated by many fans of Bleach: Worst...afterlife...EVER!
- This is actually stated by Yuichi when he talks to Chad upon Ichigo and his group arriving in the Soul Society.
- Part of the premise of Kyouran Kazoku Nikki. A group of seven (later eight) people, most of them harboring the DNA of a creature that promised to destroy the world and all of them from a dark past, live together under "Operation Cozy Family" to prevent the world from blowing up. Family members include a robot, a catgirl, a lion, a jellyfish and a girl with demon blood.
- The cast of Read or Die becomes this by the end of the series: the Paper Sisters, Yomiko, Nancy and Junior. With Nenene as the "normal" one. (Don't ever call her that.)
- The teens of Project ARMS end up as one as they are being hunted by Egrgori. Playing this trope even more straight, they all turn out to be specially bred to have ARMS implanted in them, directly going against the already established backstory.
- The Gravity Children of Air Gear fit this trope nicely. Particularly the four "sisters" that live with Ikki when the story begins
- Holland's crew in the Eureka Seven movie.
- Although some still have some family left, most Straw hats are orphans, and they consider the crew their family.
- John Byrne's Next Men comic.
- The Marvel Universe's Livewires and The DCU's Lab Rats.
- Genął. Mirrored by DV8 and the Mongolian Barbeque Horde.
- The Morlocks from X-Men.
- A fair number of the X-Men themselves. Wolverine, X-23 . . . I'm sure a bunch of the others.
- The Teenage Mutant Ninja Turtles. And various imitations.
- The cast of Runaways sort of fits this trope. After running away from their evil parents and not being satisfied with the foster care system they adopted each other as a family.
- Nocturnals. Some are refugees from secret projects. Others are supernatural entities. All of them have nowhere else to go.
- A particularly unusual (and nonhuman) example: We3.
- Scare Tactics.
- The Teen Titans from 1996 were half-human, half-alien sleeper agents that instead banded together to fight the aliens. They then stayed together, with a deaged Atom as their mentor. Other DCU characters would join them over the course of the series.
- Teen Titans: Earth One has the Titans consist of this trope, each member of the team having gained their powers from 'Project Titan' before escaping.
- Cloud, Seraph and Harridan initally appeared as this in The Defenders; being on the run from the Secret Empire. Cloud would later join the Defenders.
- Infinity, Inc. had recurring antagonists Helix; an evil geneticist had mutated them in the womb, kidnapped them at birth, and then raised them in isolation. When he died, they took stock of their options and decided on crime.
- The mutants who live in the fringes in The Chrysalids seem to adopt each other as a sort of 'tribe'/family.
- The Durona sisters in Lois McMaster Bujold Vorkosigan Saga are clones of their progenitor Lilly Durona, and are escapees from one of Jackson's Whole robber barons.
- The same series also has Terrance Cee, whose history is a pointed example of why these often don't work in real life (ie, they make you easier to find).
- Another (and more warlike) example is Audubon Ballroom from David Weber/Eric Flint, in the Honor Harrington series, who are less of a family and more of a guerrilla army of escaped Mesan slaves. It does help that their organisation is pretty big and have powerful allies.
- Connor, Risa and Lev in Neal Shusterman's Unwind, though what they are running away from is not a secret. They are running away from being "unwound", or having every body part taken away from them.
- Gypsies, by Robert Charles Wilson, is about the children and grandchildren of two world walkers who wandered into our world decades ago. The original married couple never told their kids where they were from, and punished them for the use of their powers. But the grandson of the first generation is starting to display his powers, and the last world walker from a really, really nasty dystopia has finally found them…
- The clone commandos who desert in the Republic Commando Series, though the Grand Army is far from secret by that time.
Live Action TV
- Dark Angel:
- It's consciously averted in the first season of, as the escaping X-5's decide to split up to avoid capture. However, Max acquires one of these in the second season with Alec and Joshua and later a whole city of transgenics.
- It's also played straight, with a squad of younger transgenics who stayed together (giving Max a chance to be Mama Bear).
- Babylon 5: Telepaths who were not in Psicorps attempted to run away. Some were more successful than others.
- Kyle and Jessi from Kyle XY, to some extent. Partially subverted in that they had a normal, human family as well, and probably didn't see each other in quite such a brother/sister way in the end...
- In later seasons of The Pretender, Jarod was joined at various points by a young fellow escapee and his own father, a former Centre employee.
- The clones in Orphan Black (well, except for Helena and Rachel).
- A typical throng of Promethean: The Created characters — not exactly lab projects most of the time, but often abandoned by their creators, spurned by humanity, and seeking someone for tea and sympathy.
- This is also how a motley or Freehold of Changelings can tend to look in Changeling: the Lost. They can afford to be a little pickier than the poor Prometheans, but honestly, when you've been kidnapped by beautiful and terrible Eldritch Abominations, tortured into a more pleasing (and utterly not human) form to suit their whims, survived this process, escaped back to Earth, and then found at best some Thing with your face in your place, and at worse found that Time has screwed you over quite severely in the bargain... well, as the book says, Changeling society tends to be pretty dang forgiving of its members' little.. quirks. Oh, and of course, we have the Summer, and to a lesser extent, Autumn Courts....
- For another New World of Darkness example, the recently-announced Deviant will deal with people who were changed by scientific experiments (or, in some cases, occult rituals) who are on the run from the people who made them, trying to gather the power to strike back.
- This is the backstory for Kadaj and his gang in Final Fantasy VII: Advent Children.
- This fits Team K' in The King of Fighters games fairly well. Well, after they switch Whip out for Kula, anyways.
- Actually, Whip sort of commutes between them and Heidern's Ikari squad. She's K's biological sister, after all.
- Strega from Persona 3: They aren't actually artificial humans, but they were the only survivors of a secret project to create Persona-summoners out of humans who weren't born with the talent..... too bad they ended up with something a bit closer to Team Rocket instead.
- Jack, the Little Sisters, and presumably Tenenbaum in the good ending of Bioshock.
- The Cybran Nation of Supreme Commander began as this, complete with the mad scientist/genius (Dr. Gustaf Brackman) responsible for creating them as their father figure - and said father figure is still alive and kicking one thousand years later. Although really now, they're more of a Obvious Project Refugee Country now.
- Albeit Brackman has been reduced to a brain + spinal column + cybernetic enhancements inside a vat of unknown liquid. He can only communicate with others through a life-sized 3D hologram of himself.
- The Black Mage Village from Final Fantasy IX.
- Pretty much the whole premise of Family Project.
- Hermana Larmo in Tales of Innocence runs a secret school to harbor "Gifted" children that would otherwise be captured and researched by the government.
- Eientei: Eirin and Kaguya, two Lunarian immortals on the run from the crime they committed against fellow Lunarians; Reisen, a Lunar Rabbit defector; Tewi, an Earth rabbit who host them; and later Medicine, a venomous doll that Eirin took as apprentice.
- Byakuren, rejected by humankind, gathers quite a band of Youkai followers that look up at her.
- The Lambsbridge Gang in Twig is this without the running away part, instead being employed by Radham Academy as problem solvers. While they act as a family unit, the Academy has different means of maintaining control of all of them, so that the Lambs can't all run away together due to differing priorities. When Sylvester eventually does decide Screw This, I'm Outta Here! and deserts the Academy, only Jamie chooses to join him in running away, since all the others need the Academy more than they need to be free.
- Double Subversion: Bionic Six. They were a blended family brought together when the parents adopted an Asian son and a black son. Then they were turned bionic to save their lives, after which point they were pressed into service for the government. So they were willing, given that they owed the government their lives, and the teen members got a kick out of being superheroes.
- The animals from I Am Not An Animal.
- The Mutates from Gargoyles except Fang after his Face–Heel Turn— or, perhaps, after Maggie, Claw, and Talon's Heel–Face Turn, depending on one's point of view. Its complicated. Later, most of the Gargoyle clones join them.
- Justice League features two approximate examples. The Joker's Royal Flush Gang was a group of metahuman teens (modelled on the powers of the Teen Titans and using the same voice actors from that show) which the Joker had liberated from the government's Project Cadmus and trained in supervillainy. The Ultimen (who were in turn a pastiche of the Ethnic Scrappy characters from Superfriends (and the Wonder Twins) are a borderline case, since technically they never quite succeeded in escaping the secret project.
- One Quack Pack episode has a regular ordinary family, a dad, wife, and a girl. And they're secretly armed robots hiding from the military.
- In Static Shock, She-Bang is a test tube baby engineered to have super powers, and her "parents" are actually the motherly and fatherly scientists who liberated her from her makers so she wouldn't be used as a weapon.