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They laughed at me at the university. They called my theories mad. But I'll show them... I'll show them ALL!

They're scientists, they're somewhat scatterbrained, and they are frequently working for the bad guys, often building implausible gadgetry or slightly ridiculous superweapons. They tend to wear lab coats and speak with put-on Central European accents (based on the many scientists who fled Central Europe from the Nazis and the Soviets). Sometimes they will talk like Peter Lorre, or engage in Sesquipedalian Loquaciousness. Often they will possess more than one Morally Ambiguous Doctorate.

Probably inspired by several people fictional and real: Doctor Frankenstein, Rotwang of the silent movie classic Metropolis and Albert Einstein. It's worth mentioning that while prominent scientists through the ages have often been a little... off, they are not true mad scientists: to be a Mad Scientist, both you and the science has to be mad. The one person who's come closest to this in real life may have been Nikola Tesla.

They tend to have vast stockpiles of Applied Phlebotinum available, and are frequently the manifestations of a particularly egregious Ass Pull on the part of the scriptwriters. Mad Scientists often do a lot of hand-waving and cackling as they construct or summon the Monster Of The Week or repair the villain's Humongous Mecha, which is usually only dimly visible in a gigantic foggy cloud of expository Techno Babble. When confronted about their amorality, expect them to shout that the true value of their work is "For Science!"

Some examples more than others emphasize that the bad science is incredibly broad-based. Biology, chemistry, medicine, physics are merely some of the mastered fields. (This may have been more realistic when scientists were "natural philosophers".) Technological mastery may include robotics, mechanical, electrical, and so forth, although in Real Life researchers of basic science such as university professors may not be that swift at using computers, for instance.

Despite being the type that should never attract women (unless a rare tragic figure), the Mad Scientist traditionally has a beautiful daughter for the hero to fall in love with. Or perhaps a child of much stranger provenance.

Often, nowadays, you'll see a good-aligned Mad Scientist (a Techno Wizard), whose job is usually providing the hero with their own stockpiles of Applied Phlebotinum. This character will frequently be an example of The Mad Hatter as well.

A Mad Scientist or two can be responsible for a Schizo Tech world. They also might be the only ones able to resurrect Lost Technology.

A very frequent trope, still around today. It is in webcomics however, that mad scientists have come into their own as leading characters.

Typically comes equipped with a Mad Scientist Laboratory possibly on a tropical island or in a European castle. He'll often be assisted by The Igor.

An increasingly common take on this trope is that Mad Science is a disease, either hereditary (in which case the afflicted may come from a long line of mad scientists), or transmissible through contagious ideas.

The opposite of this character is the The Professor, a brilliant scientist who is unambiguously a hero; however, they overlap more and more often lately.

See also TV Genius, Evil Genius.

Examples

Anime and Manga
  • Professor Tomoe Souichi from Sailor Moon. To be fair, in the anime version he was possessed by a demonic being that lived in his eye; in the manga, he was just plain evil.
  • Washuu, from Tenchi Muyo and its spinoff series Pretty Sammy (a heroic example).
  • Dr. Franken von Fogler from the Giant Robo OVA was introduced as a classic ranting Mad Scientist. The series subverts this trope, as successive flashbacks reveal more about his real motivations.
  • Icchan from Kidou Tenshi Angelic Layer is often mistaken for a Mad Scientist; he seems to encourage it, making over-the-top dramatic entrances, speaking cryptically about his creations whenever he can, and wearing his lab coat all the time.
    • However, his invention makes sense, is based on diligent research, operates on the notion that the principles discovered in previous discoveries can lead to new ones, is dependent on capitalism to provide funds and is profitable for mankind in general. Mad Scientists everywhere are very, very disappointed in him.
  • At least a third of the major characters in Neon Genesis Evangelion are mad, or at least amoral, scientists.
  • Mayuri Kurotsuchi from Bleach is an extreme example,an unholy hybrid of a mad scientist, an Evilutionary Biologist and an outright sociopath, openly boasting of the thousands of souls he's tortured to death in his 'studies'. Yet he leads one of the Soul Society's 13 squads (his contains lots of quirky assistants) and is seemingly a valued member. You begin to see the problem that the rest of Soul Society has with the administration... Just to hammer it home,he even has a daughter whom he made himself. His Arrancar equivalent is Szayel Aporro Grantz, who shares his twisted science. Urahara Kisuke is also very much a scientist and very much whacked out. There's a distinction between him and the other two, however, in that while Urahara is a walking moral gray area, he's not sociopathic or out for bloodshed. Ironic, given the nature of his zanpakutou.
  • Fullmetal Alchemist, instead of dealing with the Mad Scientist, revives its predecessor-trope, the almost forgotten Mad Alchemist (see below).
    • The Movie introduces a scientist who is severely ticked at the world's alchemists for making his work worthless. The "mad" part of this shows up when he reveals that he discovered Uranium and threatens the Elrics with a hand-held nuke. Clearly he never tested the thing.
  • Weiss Kreuz is almost as fond of these as it is of Mad Artists - see particularly Takatori Masafumi, and Tsuji Mayumi in Weiss Kreuz: Glühen.
  • Dr. Jail Scaglietti of Magical Girl Lyrical Nanoha Strikers. In fairness, it turns out that he's an Artificial Human who was specifically created to be that way.
  • Battle Angel Alita: Desty Nova. Just... Desty Nova. Mad laugh, human experiments, cloning, nanomachines, lack of morals, the whole works.
  • Dandankyukyu (called Dantalion or The Professor) from Shakugan No Shana. He is outrageously excitable and creates his mad experiments simply for the sake of experimenting, and not necessarily for evil means. (One suspects that if he weren't contracted to the bad guys he'd be mostly harmless). Bonus points, he looks exactly like Father Anderson from Hellsing.
  • Ginias Saharin from Gundam: The 08th MS Team, the head of the Apsalus Project, which could be best described as a miniature Death Star that kills cities instead of planets. He starts out relatively sane if overly dedicated, but he deteriorates as time goes on.
  • The Elder in Chrono Crusade is a mild example of this trope. He's not completely insane, but his inventions tend to be quirky at best and downright dangerous at worst. Some of the things he's responsible for in the series include purposefully allowing Rosette to steal an experimental bullet with a demon trapped inside so he wouldn't have to test it himself, and apparently fusing a friend with demonic legion in order to make him a better fighter. Oh, and he's a pervert to top it all off.
  • A rare female example is Nina Einstein from Code Geass, a Teenage Mad Scientist Girl. She is particularily known for being a Psycho Lesbian and inventing weapons of mass destruction.
  • Another one is Grace O'Connor from Macross Frontier. Though she doesn't heavily advertise that she is a scientist in the first place, in fact she is, and not the worst one. Given that she's also a Hot Scientist, and what a scheming, amoral, and utterly badass Magnificent Bastard she comes in the end, it's simply unfair to leave her out.
  • Sekirei has a few, but the biggest, craziest, and downright hammiest of them all is Hiroto Minaka, MBI's psychotic and manipulative CEO. He's hinted to be behind the discovery of the original Sekirei and the making of the current ones, and is CONFIRMED to be manipulating every single person in the series towards his own bizzare ends and making every character hate him in the process, but earning massive fan love for his Impossibly Cool Clothes and general general chaotic awesomeness.
  • Professor Franken Stein of Soul Eater, whose love of dissection is played for laughs early on. The "mad" aspect becomes important later on, as madness is somewhat more concrete in this world. Medusa definitely counts as well.

Comic Books
  • The original incarnations of Superman's archenemy, Lex Luthor. In the years since, he's also been a Corrupt Corporate Executive and a villainous politician.
  • The Mandarin is a Mad Scientist enemy of Iron Man. He spends his time inventing mind-controlling super-cancers that run around like a cross between the Blob and the Borg. Or inventing orbiting Hate Rays to destroy the world with madness.
  • Doctor Sivana and his family are similarly the archenemies of Captain Marvel and friends. He's a five-foot-tall gnome of a man with a chrome dome, huge Scary Shiny Glasses, and more often than not a white lab coat. His stated goals (in no particular order): To become Rightful Ruler of the Universe in fact as well as in name; to spread evil, cruelty, and nastiness throughout the cosmos; and to humiliate, discredit, and ultimately KILL CAPTAIN MARVEL! Heh heh heh heh!!! What, exactly, his incredibly attractive and affectionate late wife saw in him is a total enigma.
  • A heroic Mad Scientist in The DCU is Doctor Magnus, creator of the Metal Men.
  • In the Marvel Universe, AIM (Advanced Idea Mechanics) are a terrorist organization of Mad Scientists, who wish to overthrow the world's governments and institute a technocracy.
  • The DCU comic 52 had a secret conspiracy who was kidnapping Mad Scientists, good and evil, for a nefarious goal.
  • ...and many, many, many others. Mad Scientist is possibly the default comic-book bad guy, and is a common vocation for good guys, as well.
    • Special mention going to the Ultra-Humanite (arguably comics' first supervillain) who actually transferred his brain from the standard baldie-in-a-labcoat mad scientist's body into that of a beautiful woman. He was only another Mad Scientist in the Golden Age comics, but in the series The Golden Age, he becomes the arch villain, but poses as a hero and gets the medal of honor. He saved Hitler's brain, too. And put it in an invincible super-body.
  • D.A. Sinclair of Invincible is easily one of the most sadistic mad scientists in fiction. He started making zombielike techno-organic minions, Re-Animen, from dead bodies, which is bad enough. But he eventually moved on to live subjects, kidnapping his roomate and tearing out his vocal cords so that he couldn't scream while he operated on him (D. A. is a college student, after all, and can't afford anaesthetic). And he tore his arm off and overrode his free will. Then he started duplicating the process on homeless people. Naturally, the US Government saw to it that he served no jail time when he was caught, and gave him a cushy job making Re-Animen for military use.
  • Dr Mindbender from GIJoe is particularily mad. Cloner, Genetic Engineer, Robot designer and master of mind control and inventer of many of Cobra's bizzare superweapons. That he's bald, usually shirtless and has pecs like melons only enhances his image of insanity. He even installed mind control chips in several prominent Cobra members, and prepared for his own death by creating a clone backup. Oh, and before he became a mad scientist, he was a... benevolent orthodonist. Until his freak orthodontics accident (seriously).
  • Simon von Simon from Little Gloomy. He's got it all, from his powerful machinery, futuristic inventions (such as the television and the microwave. Before you say anything, he invented them before anyone else did), hunchbacked Halfhearted Henchman, to his seething rage for everybody but himself. Of course, the fact that his plans for world domination were motivated by Gloomy dumping him, and the fact that the series calls him on not marketing his fantastic creations to get on top in a less freaky way undermines his menace somewhat; This, in turn, is offset by his army of ravenous zombies.
  • Dr Scyk from the Danish comic-strip "Dr Merling".
  • Several villains in the Blake And Mortimer comics fall under this trope. The most notable being:
    • Wade/Jonathan Septimusin "The Yellow M"
    • Miloch Georgevich in "Sos Météores" and "Le Piege Diabolique"
    • Voronov in "La Machination Voronov". Who also ends up being something of a Karma Houdini.
  • In Ythe Last Man geneticist Dr Allison Mann claims she was illegally cloning a nephew who needed a bone transplant. She later admits this story was fictional to gain Agent 355's sympathy rather than be thought of as a 'mad scientist'; her actual motive was to spite her father who was nearing success in cloning the first human. After several red herrings we encounter the REAL mad scientist is in fact Allison's father, who was seeking to clone his daughter so he could be a better parent the next time round, yet who also sabotaged Allison's cloning experiment out of sheer spite and may have accidentally caused the plague that all but wiped out the male species.

Film
  • Most of the traditional image of the Mad Scientist probably derives from various adaptations of Mary Shelley's Frankenstein, especially the 1931 movie: "It's alive! IT'S ALIVE!" Note that the original book is wildly different - see below.
  • The 1931 Frankenstein and other horror films of the time also drew heavily for their portrayals of mad scientists on Rotwang in Fritz Lang's classic 1927 SF film Metropolis. Rotwang, in turn, draws on the Mad Scientist depictions of Frankenstein in nineteenth-century stage melodrama.
  • Dr. Michael Hfuhruhurr in The Man With Two Brains eventually becomes one of these - or, rather, a parody of one:
    German Detective: You're playing God!
    Michael: Somebody's got to!
  • The Back To The Future trilogy has Emmett L. Brown, who is a bit more cuddly than your average Mad Scientist.
  • The Spiderwick Chronicles has Arthur Spiderwick.
  • The title character of Doctor Strangelove, or How I Stopped Worrying and Learned to Love the Bomb
  • Dr. Frank N. Furter from The Rocky Horror Picture Show, who is also a Transvestite.
  • Dr. Caligari is a little bit of this and a little bit of Circus Of Fear.
  • The Woody Allen comedy Everything You Always Wanted To Know About Sex *But Were Afraid To Ask has a skit featuring Dr. Bernardo, a mad sex analyst whose experiments include measuring premature ejaculation on a hippopotamus and building a 400-foot diaphram. ("Contraception for the entire nation at once!") The segment ends with Allen's character battling one of the doctor's creations - a gigantic, disembodied human breast.
  • The upcoming film Igor satirises this entire trope with the town of Malaria having more than one mad scientist and each one of them has their own Igor. The main character Igor (John Cusack) aspires to be a mad scientist himself.
  • The film Terror Of Mechagodzilla has the character of Dr. Mafune who not only turns his own daughter into a cyborg, but he also invents a device that allows him to control the sea monster Titanosaurus.
    • Likewise, the original Godzilla had Dr. Daisuke Serizawa who invented the Oxygen Destroyer that ultimately kills Godzilla. Though, he isn't evil.
    • Also, there's Dr. Shiragam from Godzilla VS Biollante whose expirimental fusion of Godzilla's DNA, Rose DNA, and the DNA of his deceased daughter ends up causing the creation of Biollante. He's not evil either, but he's certainly mad with grief over the loss of his daughter.
  • Vincent Price in Edward Scissorhands might just be the kindliest Mad Scientist ever. His second-most-impressive creation (besides Edward) is a giant cookie-making machine.

Literature
  • In the Discworld books, the Alchemists' Guild are also Magitek mad scientists. Inverted with the character of Jeremy Clockson, subject of the quote above, who has the detachment from reality and dangerous obsession of the typical Mad Scientist because (most of the time, and in a very specialised way) he's saner than normal people.
    • The Igors of the Discworld series. Though typically the assistants of a Mad Scientist, they're known to conduct their own experiments, such as growing noses with feet, and their own special version of "self improvement."
      • Though to be fair, the Igors in general are remarkably Genre Savvy along with half of the Disc - almost to the point of self-destruction. They know their place in the chain, and how to react when that chain is shaken. In fact, the clan basically foists off the most 'modern' variant of their clan upon the Night Watch in an attempt to cease the corruption: that is to say, Mr. "Noses With Feet".
    • Making Money gives us Hubert Lavish, a mad ''economist''. With a really, really Crazy Awesome laugh.
  • The inspiration for both Mary Shelley's novel Frankenstein and the adaptations which distorted Frankenstein into a Mad Scientist came from a much older literary and popular tradition about Mad Alchemists, and their blasphemous, yet entertaining, obsessions with the creation of homunculi and the secrets of eternal life. So while the Mad Scientist might seem quintessentially modern, in fact he's Older Than Steam at least. The most well-known remnant of the old 'Mad Alchemist' trope today is the Faust myth, and its literary adaptations in Marlowe's play Dr. Faustus and Goethe's epic poem Faust.
  • Victor Frankenstein, as originally conceived in Mary Shelley's novel, was not quite a Mad Scientist. Although he sees himself as a descendant of Mad Alchemists, Shelley makes his character more rounded and his mental instability more subtly portrayed. However, within decades wildly popular nineteenth-century melodrama theatre adaptations recast him as a cackling Mad Alchemist.
  • The King of the Mountain in Enid Blyton's The Mountain of Adventure.
  • This forum story, The Mad Scientist Wars, pretty much uses this trope as its foundation stone. The players are all fans of the above-mentioned Narbonic and its new successor, Skin Horse (about a government agency that basically cleans up after Mad Scientists), so it was only natural.
    • This Troper, who is Andrew Tinker in the forum, would like to add that it's a pretty good example. Flying rabbits, lightning guns, nano-bots, and reality warping have all come into play.
  • Herbert West. Just... Herbert West.
  • In the Whateley Universe, some 'mad scientist' types (as well as other superpowered people) have the 'madness as a disease' trope. The universe has an illness called Diedrick's Syndrome that only affects some mutants. Due to an imbalance of neurotransmitters, the person can get paranoid, megalomaniac, etc., and that makes the imbalance worse, so things escalate until finally, said character is insanely screaming about destroying the planet because, say, he originally just lost his car keys.
    • Of course, you could argue that this trope applies to pretty much every Deviser and Gadgeteer, Diedrick's cases or otherwise.
  • Most of Doc Savage's foes are mad enough to the point that their death machines could not have been a large scale threat after retrieval and close examination by Doc. At least, that's what he says...
  • Sadistic pavlovian Ned Pointsman, one of the main villains in Gravitys Rainbow.
  • Dr. Impossible, of Soon I Will Be Invincible, suffers from "malign hypercognitive disorder". His mentor, Baron Ether, had the condition as well. Symptoms include not following safety protocols while working with high energy physics experiments, extreme long-term planning, robotic servants, death rays, extreme long-term planning, maniacal laughter, wondering why you just didn't get a normal job while powering up the death ray, and insomnia.
  • The villain of Hilari Bell's The Last Knight is a rare example of a mad scientist in a fantasy setting, performing dubiously ethical experiments in order to give magical powers to humans (as, in the story's universe, only plants and animals have magic).

Live Action TV
  • Degra, Dr. Crell Moset, Dr. Chaotica and numerous other specimens can be spotted on every incarnation of Star Trek.
  • Dr. Arliss Miguelito Loveless, The Wild Wild West.
  • Dr. Clayton Forrester on Mystery Science Theatre 3000; his mother later takes up the role.
    • Joel also qualifies to some degree. He built smart robots out of ordinary spaceship parts, and his invention exchange concepts are a little... odd.
  • Dr. Yes and others on Get Smart.
  • Dr. Bunsen Honeydew of The Muppet Show.
  • Professor Maggie Walsh and Warren Mears on Buffy The Vampire Slayer.
  • Jha'Dur on the Babylon 5 episode "Deathwalker".
  • Beakman on Beakmans World had the outward appearance of one, but as this was an Edutainment Show, most of his science was pretty sound. Most of it.
  • John Lumic from the Doctor Who two-parter "Rise of the Cybermen/The Age of Steel". In addition to being an Evilutionary Biologist, he explicitly considers himself above law.
    • Doctor Who is filled with Mad Scientists, ranging from the slightly unhinged, endearing sort to the completely unrepentant, omnicidal loonies. The best example is, of course, Davros, the creator of the Daleks, who easily conveyed just how twisted he was even without an Evil Laugh.
    • Don't forget the Rani!
  • Parodied on one episode of Dinosaurs: a scientist on TV gives the "They called me MAD!" speech before unveiling his latest creation, a giant living squash. When his assistant calls him mad, the scientist calmly agrees, adding that what made him seek revenge is that he's angry-mad, not insane-mad.
  • Comic Book Evil, of the sort perpetrated by MadScientists is the reason The Middle Man organization exists.
  • Heroes, Volume 3 Mohinder Suresh crosses this line when the Super Serum he's injected himself with causes him to become increasingly unstable as the season progresses.
  • Walter Bishop of Fringe, most of whose nervous tics and general mental confusion disappeared about the same time he was released from the mental asylum (he claims that they were side effects of the drugs he was taking). Of course, he's still a "fringe scientist", which means he's focused on things like teleportation, astral projection, reanimation, and diseases-that-turn-skin-and-muscle-tissue-translucent.
  • Stargate SG 1 has a woman known to many as the Destroyer of Worlds for her twisted experiments with genetics and chemistry.

Mythology
  • The mythical Greek inventor Daedalus may be regarded as the first Mad Scientist.
  • The god Hephaestus/Vulcan deserves honorable mention for his two mechanical servant girls.

Tabletop Games
  • The original Mage: The Ascension gameline had the 'Sons of Ether', a "Tradition" of technomantic mad scientists who see their magick as the ultimate form of True Science.
  • Fabius Bile of Warhammer 40000. His lab coat is made out of human flesh. That about sums up his state of mind.
    • Magnus the Red, Daemon Primarch of the Thousand Sons, arguably qualifies for this trope, though he's more of a mad wizard. He's got the reckless pursuit of knowledge, megalomania, production of the odd superweapon, and lead an entire legion of super soldiers into daemonic corruption.
    • Every Mekboy ever. When they aren't building big stompy idols of Gork and Mork, they're building chaotic field artillery or welding small guns onto bigger guns.
    • The Adeptus Mechanicus tend to get like this as you get further up the chain of command, especially with Masters of the Forge- part Space Marine, part Techno Wizard, all trouble.
  • In the Warhammer universe, pretty much any Skaven from Clans Skyre, Moulder or Pestilens. They nicely cover all three of the main Mad Scientist archetypes: Moulder are the Frankenstein types, stitching together psychotic, uh, things to make even bigger psychotic things. Pestilens are the disease merchants, mixing together various toxic goops with the eventual goal of making the perfect plague to unleash on the Overworld. Skyre are the engineers, making Warpstone shooting gatling guns, cannons that fire green lasers, and giant armoured hamster wheels that throw off green lightning indiscriminately. These three clans then sell their services to all the myriad Warlord ("normal") clans, to aid them in their conquests. For the record, the other "techhologically advanced" races have only just invented gunpowder, and most are still on bows and arrows.
  • The Demon Prince Vapula from In Nomine. He... stands out a bit from the more traditional Demon Princes.

Videogames
  • Dr. Ivo "Eggman" Robotnik from the Sonic The Hedgehog series. He has a recorded IQ of 300 and an almost admirable level of persistence.
  • Dr. Albert Wily from the Mega Man series; arguably, the heroic Dr. Light as well.
    • Wily's so nuts, some of his own creations are mad scientists, too; Most notably, Gravity Man, whose data card quote is taken from Galileo.
  • The Master from Fallout, who beneath a calm, arrogant exterior topped by the reasoning of a Well Intentioned Extremist exhibited a multiple personality disorder and overall emotional frailty.
  • Dr. Suchong from Bioshock is the sinister and detached version, the warped genius behind much ADAM research, including several plasmids, the Little Sisters, and the Big Daddies.
    • Not to mention the fact that he was the lynch pin behind virtually everything that went wrong in Rapture, including the protaganist himself — but, at least, he died an ironic death...
  • The first six members of Organisation XIII in Kingdom Hearts II were originally assistants to Ansem the Wise and his research on the Heartless. Vexen keeps up his research.
  • Professor Monkey-for-a-Head from the Earthworm Jim games. "Don't make the monkey mad, son!"
  • Dr. Curien in the House Of The Dead series. The third game has little cutscenes that chronicle his transformation from "scientist-trying-to-find-cure-for-sick-son" to "zombie-obsessed-psycho."
  • Klungo from the Banjo games. He's responsible for Gruntilda's Beauty-Stealing Machine and in Grunty's Revenge is hinted that he also created Grunty's monster army. Unique in the fact he also happens to be the The Igor.
  • Ewei/Wei Queyin from Romancing Sa Ga is a solid example. He does not have a lab assistant, however, but does have a Cosmic Keystone.
  • Doc tor! Gregor! Hoffman!
  • Hojo from Final Fantasy VII is truly an archetypical Mad Scientist, right down to his outfit and sociopathic habit of sacrificing a great deal for the sake of scientific discovery (which, in his case, underlies his utter insanity). When you get down to it, Hojo may very well be the leading villain in the game, considering that most of the conflict in the game is indirectly his fault.
    • Cid, one of the trademark characters of the Final Fantasy series, is sometimes portrayed in this light. Examples are in Final Fantasy VI, where, despite working for The Empire, he is a sympathetic character, and in Final Fantasy XII, where he is a main villain and fits this trope to a T.
  • The game Psychonauts. The villain Dr. Loboto has all the trappings of a mad scientist, while using the style of his doubtless-failed career in dentistry.
  • City Of Heroes and City of Villains have several of these, not including player character concepts: Dr. Aeon is the foremost example, tapping the energy of a slumbering demon in order to power his city. There's also Vernon von Grun, a Mad Scientist-In-Training Lab Assistant.
    • The Clockwork King thinks that he's a Mad Scientist, but he's actually an extremely powerful psychic whose creations work because he believes they do.
      • Brutally expanded on in a high level story arc, where an alternate universe version of the Clockwork King has realised his own sanity, and focused enough to <i>conquer the entire planet and kill everyone on it</i>.
    • And there's Dr. Vahzilok, obsessed with conquering death, with fairly typical results.
    • Don't forget the Council, of which all of The Center's generals are mad scientists (SIX of them!). The lower ranks of the Council are filled with their creations.
    • It's mentioned at least once that Arachnos (the Big Bad Organization ruling the isles in which the game takes place), intentionally trains and recruits mad scientists, in order to stay ahead of the mad science game, ensuring their dominance above lesser criminal organizations.
  • Guildernstern from the Onimusha series of videogames, and his successor in the fourth installment Rosencrantz (see a pattern here?), both qualify as mad scientists. Guildenstern can't help but experiment with demon and human anatomy to come up with truly horrifying monsters for the protagonist to face. Even in the second game where he is never seen, he is mentioned in many in-game texts as the reason your character has to go through such hell with biomechanical demonic constructs plaguing him at every other turn.
  • Advance Wars had Lash, a girl genius version of the mad scientist. The reboot Days of Ruin has Caulder/Stolos, probably the most extreme mad scientist ever. Among his creations are the games equivalent to nukes, a giant bomber, cloned humans intended to be used as Super Commanders, and most of all, a virus that kills its host by growing flowers all over it's body. He also loves to manipulate people into fighting each other just so he can observe them and views humans as little more than test subjects... Including himself.
  • Final Fantasy IV gives us Dr. Lugae, one of Rubicante's servants. He gleefully turned Edge's parents into hideous monsters, and when the party confronts him attacks them with a giant robot named Barnabas before turning into a mechanical skeleton to continue the fray. When the heroes finally reach Rubicante, he actually apologizes for Lugae's actions.
  • At least three Devil May Cry villains have been scientists researching, experimenting on and trying to create demons - Arius in the ignored title, Agnus in Devil May Cry 4 and Chen from the second novel. It's debatable as to how "scientific" this line of work is, though, so we could call them Mad Pseudoscientists or something.
  • "Thief" features Father Karras of the Mechanists. He's mentioned in the first game as the fellow responsible for Garrett's replacement ocular, but by the second instalment, he's gone completely 'round the bend and is cheerfully intent on bringing about The End of the World As We Know It. He also has a preoccupation with Garrett...
  • Lemon Browning from Super Robot Wars. While not really 100% evil, she did conduct very mad researches that borders on playing God, such as the premise of W Numbers, which is to create an Artificial Human that is as perfect as possible compared to usual humans. She's also sort of the Evil Twin of Excellen Browning.
  • Andross in Star Fox, who employed several bio-weapons (as in, lifeforms created as weapons) in Star Fox 64 and Command. The later however somewhat redeems his actions by revealing that he had been working on a device that would terraform the aptly named planet Venom into a more inhabitable one. Which just happens to be the perfect counter to the new threat, which come from the acidic oceans of the planet.
  • Doctor Fred Edison from the PC game Maniac Mansion, its sequel Day Of The Tentacle, and the television program arguably based on them. Granted, his desire to take over the world and generally be evil was planted in his head by a purple meteor, but as the sequel shows, even when he's not being controlled, Fred is still a very whacked-out and amoral scientist.
  • The Tales Series has a few of these.
  • Bob Page from Deus Ex certainly fits this trope. Hell, the man has built entire multi-national conglomerates dedicated to such "grey area" pursuits as transgenics, bioweapons, espionage, nanotechnology, and cybernetics; all as part of a plot to rule the world.
  • Every single villain in the Crash Bandicoot franchise is either a mad scientist (usually with a first name starting with the letter N, which lends itself to Punny Names such as N.Gin, N.Brio, N.Tropy. N.Oxide and N.Trance) or a hideously mutated anthrophomorphic animal created by said mad scientists.
  • Dr. Kranken from Viewtiful Joe 2 fits the trope (like everything else in the games) to a stereotypical T.

Webcomics
  • Casey And Andy was created with the tagline "mad scientist roommates who periodically die". Both the eponymous mad scientists have, frequently, died, often at each other's hands, and often while indulging in mad science experiments. It doesn't help that one of them dates (a female) Satan, and their neighbour is an extreme Weirdness Magnet who is also an international jewel thief.
  • Girl Genius is set in an alternate timeline where "Mad Scientists rule the world. Badly." Some people are born as "Sparks", with Mad Scientific ability as an inheritable trait — accompanied with a tendency to go into a berserk, ranting fury, and a strange charisma to gather flunkies with.
    • Mad Scientists seem to actually outnumber sane scientists in this world. Even those without the "Spark" seem a little crazy.
  • Narbonic has "going Mad" as an inheritable genetic disorder. The main characters are a mad scientist, her hapless lackey, her gun-toting assistant, and a superintelligent gerbil she created.
  • A Miracle Of Science, is set in a future where Mad Science is a memetically-transmitted mental disease.
  • Nukees features Gaviscon van Darrin ("I'm not mad, just really disappointed"), Danny Hua (creator of the Giant Robot Ant), and His Royal Highness King Luca, Monarch of the Nuclear Engineering Department of U.C. Berkeley.
  • Umlaut House and its successor involve several mad scientists, of both good and evil varieties, and even had a Mad Science Convention.
  • Sluggy Freelance has Dr. Schlock, time-traveling expert of Inflatable Technology, and Riff, a violently-minded tinkerer. And they're two of the good guys.
    • And let's not forget Dr. Crabtree, who created Y2k incompliant nanites that nearly killed off most of humanity, and turned herself into a nanite cyborg. And Dr. Steve Hereti, who claimed to have created Oasis and could control her via a wrist watch. And Dr. Scab Moreaureau, who created "Rock 'Em, Sock 'Em Gas", which forces two DNA strands to battle each other for supremacy to make genetic clean-up a fun game for the kiddies. Did I mention he's one of Santa's Elves? Yeah, Sluggy Freelance is lousy with Mad Scientists.
  • Mad About U. is about a college for mad scientists.
  • El Goonish Shive has Tedd Verres, a teen Mad Scientist, and Dr. Germahn, as Stereotypical German Scientist of the 'good, but mad' variety. Tedd also has an Evil Counterpart from a Mirror Universe, who seems to be determined to kill all of his alternates. Finally, there were the scientists who worked on Project Lycanthrope, only one of whom lived to tell the tale (Because he was caught for his fatal mistake before their gruesome consequences applied, oh the irony).
  • General Protection Fault has Nick Wellington and Dr. Wisebottom (his uncle), not to mention Nick's evil Mirror Universe duplicate, Emperor Nick. There has been discussion of an "Inventor's Gene" running in the family.
  • Schlock Mercenary has several, most notably Kevyn Andressyn. One particular Mad Scientist, 'Gav' Bleuel (who is the cryonically-preserved author of Nukees) accidentally duplicated himself millions of times over, making himself one of the largest human ethnic groups in the galaxy.
  • Jyrras Gianna in Dan And Mabs Furry Adventures. Dabbles in mixing science and sorcery (though he is not a wizard himself), invents a 'cosmetic patch' that alters one's appearance, builds hypertech weaponry out of boredom, and accidentally created new life forms twice (three times, if you count his part in the creation of the Mows). Unlike most mad scientists, he had enough on the ball to make a fortune from his inventions.
  • Jordan Kennedy in Exploitation Now!, an embittered and tragic Teen Genius who is the last survivor of a project to enhance human intelligence to super-human levels. Known for holding countries for ransom with stolen nuclear weapons and an orbital laser or two.
  • Morgan La Fey, in Arthur King Of Time And Space is an amoral sorceress in the baseline arc, but a Mad Scientist in the Western arc. And in the future arc, she's an amoral scientist and a Mad Sorceress.
    • The same webcomic also applies elements of the Mad Scientist trope to King Pelles and his daughter Elaine of Carbonek, and their quest to create the ultimate hero of Christianity (Galahad), by merging their line with Lancelot's. The newspost under the strip revealing this plan (and that Elaine is based on Helen Narbon) calls them "Mad Theologians".
  • Most members of the Society of Inventors in Scary Go Round are in fact somewhat benevolent mad scientists. Other characters in the series (such as Archie Stanwyck and the monkey-obsessed Dr. Petrescu) are mad scientists pure and simple. Especially Petrescu, who's idea of a mobile phone is a normal landline strapped to a monkeys head.
  • Eric, the nerd from Loserz, having a mad scientist moment.
  • Smic, also known as Sir Reginald, is a British mad scientist of neo-victorian style. His antics include, harnessing the power of sunspots to fill a house with pizza, defeating an acid monster with his bare hands and raising the recently deceased
  • Molly the Peanut Butter Monster, Galatea the Other Peanut Butter Monster, and Dean Martin in The Inexplicable Adventures Of Bob. Poor Dr. Jean Poule would probably qualify as well, with her bizarre pet project which accidentally generated Molly—if not for the fact that Jean is, in many ways, the sanest person in the whole comic, a quality which in her universe is actually a bit of a handicap.
  • In Flintlocke's Guide to Azeroth, the group of engineers who constructed the Ultimate Goblin Engineered Weapon, and the titular character.

Web Original
  • The titular character of Dr. Horrible's Sing-Along Blog is very obviously drawn from this trope's cliches. With a few tweaks.
  • Sukebe from Pokegirls - in an odd application of the trope, he does succeed in bringing about the Apocalypse... mostly. But it's not compete, and the world got better eventually. Still, he will always be remembered as having 'showed them all', that's for sure.

Western Animation
  • Professor Farnsworth on Futurama takes this to the lengths of parody and beyond. Case in point:
    • "Even I laughed at me when I proposed the cross-species genetic analyzer, but I guess I showed myself!"
  • Professor Frink is a rather more amicable Mad Scientist, always apologetic when things go wrong with his inventions, and a passion for inventing crazy things like self-aware robots that only scrub floors, auto-diallers with retractable wheels, automatic tap-dancing shoes, buildings that can sprout legs and run away from danger, and hamburger earmuffs.
    • Frink: (as a radio controlled baby-plane with his son in it crashes) "Oh dear. My wife is going to kill me."
  • The Brain of Pinky And The Brain.
  • Dr Karbunkle in Biker Mice From Mars.
  • Dexter, main character of Dexters Laboratory. And his rival Mandark.
  • Dr. Blight on Captain Planet And The Planeteers is literally mad. She's genuinely, clinically insane, and in the real world would almost certainly be institutionalized.
  • Simon Bar Sinister from Underdog.
  • Dr. Mephesto on South Park. The guy's greatest experiment is a FIVE ASSED MONKEY!
  • A fairly large share of the Recurring Characters on Kim Possible, notably major antagonist Doctor Drakken. But hey its not like any of them are a real threat anyway.
  • Parodied by Sheep In The Big City's Angry Scientist (who becomes especially angry whenever anyone incorrectly refers to him as a mad scientist).
  • Professor Norton Nimnul from Chip and Dale's Rescue Rangers
  • Dr. Weird from Aqua Teen Hunger Force.
    Dr. Weird: "Gentlemen! I have created... this thing."
    Steve: "What is it?"
    Dr. Weird: "I don't know! Stand over here."
    Steve: "What, over here - hey!"
    Dr. Weird: "It works! I am one can short of a six-pack! (Evil Laugh)"
  • Chrome Dome from The Tick. El Seed and the Breadmaster may also quality for developing formulae that make plants come to life and bread explode, respectively.
  • Dr. Bad Vibes from C.O.P.S.
  • Megavolt from Darkwing Duck. Likewise Bushroot, who's usually ignored in this capacity, because his "mad science" is botany.
  • Dr. Jumba Jookiba from Lilo And Stitch (although he prefers to be called an "evil genius.")
  • Dr. Sevarius from Gargoyles isn't quite mad so much as he is amoral, but he displays a touch of the theatricality that is the hallmark of the best nutty professors.
    • Then again, he is being portrayed by Tim Curry. Go figure.
  • Dr. Cinnamon J. Scudworth of Clone High certainly qualifies, even though his day job is as a high school principal.
  • The Dark Knight always seemed to be neck-deep in mad scientists on Batman The Animated Series. Within the first five episodes of the show, he runs afoul of Man-Bat, the Scarecrow, and Poison Ivy, scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who called his sanity into question.
    • Yes, killing them all will show that you are PERFECTLY sane...
  • Johnny Test's older sisters Susan and Mary are both Mad Scientist teenagers. Also their friendly enemy, a.k.a. "Bling Bling Boy".
  • The title character of