->''"It is the nature of men to make monsters, and it is the nature of monsters to destroy their makers."''
-->-- '''Dr. Harlan Wade''', ''VideoGame/FirstEncounterAssaultRecon''

The AncientConspiracy is nearly ready to make their big move and conquer the world. Their mad scientists have perfected a new and incomprehensibly powerful form of AppliedPhlebotinum that will overpower any conventional armies that stand in their way.

[[GoneHorriblyRight There's just one small problem...]]

# The {{Mad Scientist}}s tested it out on an unwilling victim who has now escaped and might be gunning for revenge.
# The victim was willing, but the process was flawed and produced an uncontrollable PsychoPrototype.
# The victim was willing, but after the procedure, he learns about the context of the villain's goals, and promptly turns on his master.
# The victim was willing, and the process worked perfectly - but the victim had an agenda of his or her own and feigned loyalty to the people who conducted the procedure solely to obtain this power.
# The victim was a captured good guy, and his upgrades would also involve being forcibly turned evil - but the villain was interrupted before this crucial last stage.
# The phlebotinum has somehow fallen into the hands of Average Joe, who initially wasn't even aware about the Conspiracy but decides to confront them with his newfound power once he finds out the truth.
# The phlebotinum itself, if [[SentientPhlebotinum it has intelligence]] of [[EmpathicWeapon some sort]], has flat-out [[TurnedAgainstTheirMasters gone rogue.]]

Even if the beneficiary of the phlebotinum is not initially opposed to the conspiracy, it won't be long before they KickTheDog or otherwise cross the line in their efforts to get their technology back.

Thus, in the ultimate show of irony, the PhlebotinumRebel is born: A PersonOfMassDestruction, given power ''by the bad guys themselves'' and destined [[HoistByHisOwnPetard to be the only person capable of defeating them]]. [[SarcasticClapping Bravo]], {{Evil Overlord}}s.

While phlebotinum is usually a ForgottenSuperweapon or DisposableSuperheroMaker [[NoPlansNoPrototypeNoBackup that cannot be replicated by the good guys]], villain-developed versions may very well remain active throughout the show in order to provide the hero with evil counterparts that share his power. The reason the hero is able to prevail varies:

# Sometimes the hero is (coincidentally) the only one able to use HeroicWillpower to resist [[TranshumanTreachery the side effects]] of PsychoSerum.
# Sometimes, the first batch of phlebotinum is a SuperPrototype that is less potent than the mass-production version.
# Sometimes, the key is actually limiting the dosage or potency of the SuperSerum so that the recipient would also retain the advantages of a normal human rather than be subject to [[OneWingedAngel massive bodily alteration]].
# Sometimes, it's simply the ConservationOfNinjutsu in effect.

FaustianRebellion is a variant. Entire groups of such rebels may result from GuineaPigFamily and SecretProjectRefugeeFamily. SubTrope to ProHumanTranshuman. The more heroic types of SuperSoldier often have this for their BackStory. Often the result of PlayingWithSyringes. A particularly unlucky example will also be a PhlebotinumMuncher or FlawedPrototype. Most cases of this are preceded with a particularly obvious WhatCouldPossiblyGoWrong. A {{Gundamjack}} is when the phlebotinum is stolen by another faction as opposed to going rogue itself. Related to EscapedFromTheLab.



[[folder:Anime & Manga]]
* The nine heroic cyborgs of ''Manga/{{Cyborg 009}}'', escapees from the Black Ghost arms manufacturing organization.
* In ''Manga/{{Bleach}}'' you find out that [[spoiler: Aizen orchestrated EVERY SINGLE EVENT that led to Ichigo becoming so unbelievably powerful ([[UnreliableExpositor or so he claims]]. Just to absorb him.]] In the end, however, things [[NiceJobFixingItVillain backfired]] and [[spoiler: Ichigo and Urahara defeat Aizen.]] It's eventually revealed that [[spoiler:Aizen exaggerated somewhat; the events that led to Ichigo's birth and his wide array of powers were a result of one of Aizen's schemes ''not'' going as planned some 20 years ago... but Aizen let it play out because he was fascinated by the possibility of a [[ComboPlatterPowers Shinigami-Hollow-Quincy hybrid]].]]
* Ikuro Hashizawa from ''Manga/{{Baoh}}'' (implanted with a brain parasite that transforms him into an armored, acid-touched, needle-hair-throwing killing machine... but which will kill ''him'' in 111 days as it reproduces).
* ''Manga/{{Claymore}}'' is a great example. [[spoiler: Miria led a rebellion against the organization that gave her yoma powers. Even though her first attempt failed, she inspired all the other warriors as well as 6 comrades who had defected with her six years ago to uprise and effectively defeat the organization once and for all.]]
** Even more than that: [[spoiler: every single enemy of the organization on the island, that is the yomas, the awakened beings and the rebellious claymore have directly received their powers from them.]]
* Sho Fukamachi from ''Manga/{{Guyver}}'' stumbles across one of the only three Bio-Booster Units left on Earth, after they are stolen from Kronos.
** ''Guyver III'' is an even stronger case, as he bonded with a G-Unit specifically to take Kronos down. Of course, he wants to take over the world himself and sees Sho as more of a tool than a friend or ally.
** There is yet another example in the form of [[spoiler:Masaki Murakami]], who was one of a number of humans used as "practice" to upgrade one of the villains' powers, but managed to escape. Somewhat subverted, as he's since become [[spoiler:the new 13th Zoalord, Imakarum]].
** Then there's former Zoalord [[spoiler:Richard Guyot]], who looks to have survived [[spoiler:having his zoacrystal ripped out by Archanfel]]. And [[spoiler:Aptom]], an irreproducible "Lost Number" who just decided to stop obeying orders one day. And the recent [[spoiler:female Guyver]], seen tearing up a Kronos compound for reasons unknown... Come to think of it, is there a single enemy of Kronos that ''isn't'' powered by their own Phlebotinum?
*** Given that they're the ''only'' source of Phlebotinum? No.
* The cyberpunk/fighting classic ''Manga/{{Gunnm}}'' showcases a host of examples along the entire work, including several spoileriffic ones:
** [[BountyHunter Hunter-Warrior]] Zapan, after being granted a [[GreyGoo Berserker]] [[LostSuperweapon Body]], escapes all sort of control and goes on a [[RoaringRampageOfRevenge indiscriminate killstreak]] against every person he knows, with the intent of drawing Alita's attention and killing her. [[spoiler: subverted in that Desty Nova never intended to exert any sort of control or restraint over this particular creation]]. Type 2.
** [[spoiler: Desty Nova isn't only keen on invoking and enforcing this trope, or at least generally making it happen: he's an example himself. One of the select few tiphareans without limiters in their brain chips, he either left the hanging city of his own volition or was kicked out; settling on the surface to pursue his Karmatronic, cybernetic and nanotechnological research without any kind of restraints whatsoever. Such research usually involves gruesome mutilations, unneeded "upgrades" and an absolute disdain towards informed consent. A very interesting blend of Types 2 and 4, or inversion of types 3 and 5, in that he turned against his masters because his capacities were too dangerous to waste them; and that the crucial part left out in the process are precisely ethical restrictions.]]
** Sechs, [[CloningBlues one of several copies of the protagonist]] left to their own devices, decides to destroy all others and the source material to "become the original". [[spoiler: After failing to destroy the original, Sechs starts to diverge heavily, even adopting a male identity.]]. Originally part of the Tuned elite units under Tipharean control. Type 7.
** [[spoiler: Starship Cult leader Whophon. The results of a [[GoneHorriblyRight failed experiment on the human psyche]], somehow [[EscapedFromTheLab survived the destruction of the facility where he was created]]. Paramount psychic illusionist, becomes a sort of anti-messianic figure after a madness cultist finds him]]. Type 2.
** [[spoiler: Super Nova: after [[VillainWithGoodPublicity Aga Mbadi]] steals one of [[MadScientist Desty Nova's]] brain chips, he reactivates it in a new body with upgraded powers over machines and intellect. Needless to say that an evil clone of an already evil (or at least amoral) character only does as he pleases.]] Type 7.
** [[spoiler: The imperfect clones of Desty Nova, even though most of them seem to be mentally handicapped, are able to cooperate and eventually prove themselves capable of outwitting the source material through low cunning and sacrifice, helping Ido and Kaos to bring him down. The clones were originally decoys that helped Desty Nova "respawn" safely]]. Type 7.
* ''Heavy Metal Warrior Xenon'': Amnesiac teen Asuka Kano discovers he's been extensively cyborged by the evil Red Sea organization.
* The eponymous robot from ''Anime/BtX'', who helps Teppei go against the Machine Empire.
** In the anime, Teppei's PowerFist also turns out to be reverse-engineered from the CosmicHorror that serves as the BigBad.
* ''Anime/GuiltyCrown'': Ouma Shu gets implanted with the Void Genome, an extremely powerful [[GeneticEngineeringIsTheNewNuke genetic weapon]], [[PowersInTheFirstEpisode at the end of episode one.]]
* Hagane Yakushimaru from ''Hagane'', a semisequel to ''Xenon'': the Red Sea has branched out into genetics and uses "parasite DNA" culled from highly skilled dead people to grant their skills to the living. This will eventually cause the recipient's mind to be completely overridden by the donor's. Hagane, a high school girl (for a change), has been given the sword skills of UsefulNotes/MiyamotoMusashi; she joins up with rebels who've been dosed with Billy the Kid and Hanzo Hattori.
* The kids from ''Manga/ProjectARMS'', given super-powered nanotech prosthetic limbs by the immensely influential Egrigori conspiracy.
* Partly subverted in ''Manga/{{Parasyte}}'', in that we never actually run into whoever dispatched the Parasites to Earth.
* Dr. Jail Scaglietti of ''Franchise/LyricalNanoha'' is a MadScientist obsessed in creating [[SuperSoldier Artificial Mages]]. His work comes to fruition when [[spoiler:Precia Testarossa]], grieving over the loss of [[spoiler:her daughter]], completes his research through Project [[spoiler:Fate]] and creates the first successful Artificial Mage through cloning. As the creation of Artificial Mages are explicitly banned by the Time-Space Administration Bureau, Jail is considered an inter-dimensional criminal, and by the third Season, has had a highly-ranked enforcer tracking his every move for many years. The name of the enforcer? [[spoiler:''Fate'' Testarossa Harlaown]]. Let's just say that [[SuperPrototype her name isn't a coincidence]]. Though it's subverted since they simply view him as a dangerous criminal to be arrested.
** [[spoiler: Subaru and Erio,]] who are products of the same research, participated in thwarting his plans too.
** [[spoiler: Jail himself]] is also an example. [[spoiler:Corrupt elements of of the TSAB decided to create their own MadScientist. It worked. [[GoneHorriblyRight Until he killed them and went into business for himself.]]]]
* The title character of ''Anime/TekkamanBlade'' was transformed into a powerful Tekkaman to serve the alien Radam, but his father managed to stop the transformation before the brainwashing stage and sent him back to Earth to stop the invasion.
* Tongpu in the ''Anime/CowboyBebop'' episode "Pierrot le Fou" underwent secret biological enhancements aimed at turning him into a super-soldier, but the process drove him insane. He made a bloody escape from a secure facility and became an almost-unstoppable assassin -- the [[MonsterClown Mad Clown]] of the title -- with the mind of a [[PsychopathicManChild demented child]].
** Vincent, the villain in TheMovie, was one as well.
*** Except that it wasn't the phlebotinum that made him awesome, he started that way. The experience caused by it just unhinged him.
* ''Anime/CodeGeass''. C.C., Lelouch, [[spoiler: as well as Rolo and Jeremiah]] are all examples of this in their own way, the AncientConspiracy being the Geass Order.
** C.C. ''is'' a SuperEmpowering Code Bearer who defected from the Geass Order, having once been its leader. She gives Lelouch Geass, and later helps him [[spoiler: massacre the Order]].
** [[spoiler: Rolo was an assassin trained and empowered by the order and sent on a mission, one of many in his life, to pose as Lelouch's brother and kill him if necessary. He]] defects to Lelouch and helps in the above incident as well. [[spoiler: Jeremiah]]'s situation is similar to his.
* ''Anime/ValvraveTheLiberator'', a SpiritualSuccessor to Geass, uses this as well, in two variants.
** The Valvraves' power comes from [[spoiler: The Magius, the series' real AncientConspiracy, enough to earn them the FanNickname "Space Vampire Illuminati. However, the Valvraves were made by [=JIORan=] scientists without the approval of the Magius, and the heroes end up using them to expose the Magius and overthrow them from their power over the world.]]
** In a more personal way, L-elf's rebellion against Cain, and the Karlstein Institute, who made him the [[OneManBrigade soldier he is]].
* While it's not revealed until later on, ''Manga/KemekoDeluxe'' has elements of this.
* [[spoiler: Al]] in ''Anime/{{Blassreiter}}'' becomes one of these [[spoiler: after being resurrected by Wolf as a loyal Amalgam soldier]]. At first, he's BrainwashedAndCrazy, but seeing a reminder of his past life snaps him out of it. [[spoiler: He then [[CrowningMomentOfAwesome blows off the top of Wolf's head]], allowing Hermann to finish him off, and then [[TearJerker kills himself with his own sniper rifle]], rather than continue to live as an Amalgam.]]
* In the ''Homecoming'' segment of ''Anime/HaloLegends'', Daisy-023, Ralph-303[[note]]later retconned to "103"[[/note]], Joseph-122, and two other Spartan-II trainees try to escape the training facility on Reach to go back to their own homes. [[spoiler:Joseph gets caught before even getting off the planet, the two nameless guys commit suicide after finding out that they've been replaced with clones (and killing said clones), and Ralph and Daisy are both recaptured (Daisy eventually becomes a full Spartan, while Ralph washes out and later joins the Marines) and end up [[DownerEnding getting killed fighting the Covenant]].]]
* [[spoiler: Crona]] in the ''Manga/SoulEater'' manga does it TWICE, once against [[spoiler: [[MagnificentBastard Medusa]]]] and the other time back to her again, after having helped the DWMA.
* Ichise in ''Anime/{{Texhnolyze}}'' is this initially. He was given cybernetics, usually reserved for the upper class, by a Doctor with a willful and independent streak herself, so she either expected it or was willing to accept it as a consequence of experimenting with the hardware's limitations. Eventually he comes back around to supporting Onishi, but that's after he's fallen from favor with the ruling circle and become a rebel himself.
* Maggie, Michelle and Anita of ''Anime/RODTheTV'' are an example of this. It was revealed that [[spoiler: Paper Users were fabricated and there'd been multiple teams of "Paper Sisters"]], but were all conveniently killed before the start of the series. However, though they were never related to begin with, Anita takes this time to get mad at them for not actually being her sisters. However, she gets over herself and [[spoiler: they later bring all of Dokusensha to its knees.]]
* Androids 17 and 18 in ''Manga/DragonBallZ''. [[spoiler:Transforming a pair of unwilling test subjects into a more powerful model than you transformed yourself into wasn't such a good idea, was it Dr. Gero?]]

* The current ComicBook/BlueBeetle, recipient of technology devised by unfriendly aliens.
** So was the first (though only through {{Retcon}}) but not the second.
* The three cybernetically modified animals from ''ComicBook/We3'' were created by the government and escaped with the help of their veterinarian. They didn't really know what to do when they left.
* In Fleetway's ''ComicBook/SonicTheComic'', Dr. Robotnik once copied his own brain patterns and put them in a super powerful robot body so he would have a competent underling, failing to consider whether or not a physically superior version of himself would be too happy with that arrangement.
** There's also Shorty/Shortfuse the Cybernik.
* The former ComicBook/{{Batgirl|2000}}, Cassandra Cain. Through a [[TrainingFromHell horrifyingly abusive system of childrearing]], her father created her to be one of the best (if not the best) martial artists in the world. Given that she became Batgirl [[spoiler:and it took [[BrainwashedAndCrazy mind controlling drugs]] to execute her FaceHeelTurn, and even then it was temporary]], his idea of creating the perfect assassin clearly didn't take.
* ''ComicBook/{{Spawn}}'': The dead guy turned into a NobleDemon by Hell, who wanted him as an assassin. Didn't turn out so well for them.
* Dagon of ''Team Titans'' is a really [[WhatAnIdiot idiotic]] example of this. So you're an evil mad scientist in the employ of a tyrannical dictator, and you've decided it would be neat to give him some vampire soldiers by infusing normal humans with Dracula's DNA. Naturally, the person you test the process out on is a captured member of the rebel forces who really, ''really'' hates everyone on your side... yeah. This works out as well as you'd expect.
* ''[[ComicBook/EarthX Universe X]]'' turned ComicBook/CaptainAmerica into an example of this via its standard {{Retcon}} technique, revealing that the [[SuperSerum Super Soldier Serum]] was actually a ''Nazi'' research project carried out by German moles working in the U.S. Makes a twisted kind of sense in some ways (take a look under the mask, after all), but seems unnecessarily risky.
* ''ComicBook/XOManowar'' of ''Creator/ValiantComics'' was a tenth-century Visigoth kidnapped by evil aliens. He [[PhlebotinumRebel promptly broke free]], bonded with the most powerful PoweredArmor suit they could build, and escaped to (thanks to relativistic time dilation) 1990s Earth.
* ComicBook/{{Wolverine}} of ''ComicBook/XMen'' was already a highly-skilled, experienced, and ferocious soldier when he received an indestructible skeleton from Weapon X. However, he was ''not'' happy when he woke up in a water tank with no idea who he was, where he was, or what the hell he was doing there...
* Friday in ''ComicBook/RogueTrooper'' turned against Highsight when he discovered they were commanding both sides.
* ''ComicBook/TheAuthority'': Apollo and Midnighter. Originally, they were created as part of a secret superhero team by ComicBook/{{Stormwatch}} Weatherman Henry Bendix. Unfortunately, Bendix was a total psychopath, and sent his loyal creations into a trap to be destroyed. Apollo and Midnighter were the only ones to escape with their lives, and it took many years (and the death of Bendix) for them to reconcile with Stormwatch.
** In ''ComicBook/{{Flashpoint}}'s Project: Superman'', a miniseries which stars an alternate version of Apollo, he is once again a super soldier, but becomes a PsychoPrototype after being pumped full of Doomsday's DNA and treated like a monster by those who created him. After killing some of his own squad on a mission, he's locked away for years, and then orchestrating an elaborate escape plan.
* ''Comicbook/GhostRider'': Ghost Rider was bound to a demonic power, which he then uses to fight evil.
* Subverted in ''ComicBook/CaptainAtom'': Nathaniel Adam was certainly not a completely willing test subject of the Silver Shield Project (he had been falsely convicted of murder and treason, and volunteering was the only way to avoid his sentence), and he had every reason to hate the head of the project, Wade Eiling, and neither Eiling, [[HerrDoktor Megala]], nor anyone else on the project had any idea that it would give Nate [[PhysicalGod incredible superpowers]], but despite all of that, [[MagnificentBastard Eiling was still able to manipulate]] Cap into working for him.
* V in ''ComicBook/VForVendetta.''
* In the ''ComicBook/AstroCity'' story "Pastoral", Roustabout. The story's big fight is Team Carnivore, openly avowing they will drag him back to their bosses so the bosses can take him apart, figure out why he works, and fix the team.

* In ''Fanfic/ProjectChimeraTheAtticHypothesis'', one of the most powerful recombinants undergoes a Psyche Break, courtesy of Professors Cypress and Heath. You know what a smart idea looks like? [[IdiotBall Not that.]]

[[folder:Films -- Animated]]
* In ''WesternAnimation/{{Megamind}}'', the title character gives the power [[spoiler:of his now-deceased archnemesis, Metro Man, to a random schlub, Hal Stewart, creating the superpowered Titan.]] In an interesting take on the trope, Megamind actually ''wants'' his Phlebotinized creation to fight against him; but it rebels nonetheless by [[spoiler:playing a little too rough.]]

[[folder:Films -- Live-Action]]
* In ''Film/TerminatorSalvation'' the character Marcus [[spoiler: is turned into a Cyborg and ''persuaded'' (his memories are erased and new ones are implanted) to help John Connor and lead him to the Skynet base. Once he finds out he was actually doing Skynet's bidding, as intended, he tears away his link to Skynet to help the rebel cause. In the end he gives his own life (well, his still-human heart) to save John who was mortally wounded.]] The Alternate Ending has [[spoiler: John Connor ''die'', and Marcus assume the identity.]]
* Inverted in the ''Franchise/{{Alien}}'' series. That vicious species of monsters the government thought would make perfect weapons? Tend to kill all their good guys. [[ExpandedUniverse The same thing may or may not have happened to the race that may or may not have originally created them]].
* In ''Film/MeatballMachine'', the main character gets partly infested with one of the [[BodyHorror alien parasites.]] All it does is make him a badass HollywoodCyborg, unlike the other characters that it happens to.
* ''Franchise/RoboCop'': [[Film/RoboCop1987 The first movie]] and ''Film/RoboCop3'' featured the heroic version, and ''Film/RoboCop2'' featured the villainous version.
* In ''Film/TheIncredibleHulk'' (2008), we have the [[BloodKnight charming and dedicated]] Emil Blonsky, who was already hopped up on a supersoldier cocktail before receiving a ''further'' injection of Hulk serum on top of ''that''. The only justification given for pimping out a mental case like that was to catch Bruce Banner, who is an okay guy if you [[BerserkButton don't piss him off]].
** Well, that and Mr. Blue just wanted to see what would happen.
--->'''Blue:''' ''(while being choked, and after warning about side effects)'' I... didn't say... I was unwilling."
** Of course, it wasn't the Hulk serum that made him mentally unstable, it was the incomplete Super-Soldier serum. Blonsky was a pretty cool guy prior to that injection. Just a guy doing a job with no interest in ever being more than a soldier. A man seeking a WorthyOpponent in the form of a challenging mission. A man who does what he does, and wants to do it well. Like the general himself, Blonsky becomes a bit obsessed with the power of the Hulk. The deleted scenes go on to enforce this interpretation of the character, and stress the imperfections of the super-soldier serum.
* Kiryu (a.k.a. [[Film/GodzillaAgainstMechagodzilla Mechagodzilla 3]]) is a cyborg created [[spoiler:from the remains of the original [[Film/{{Gojira}} 1954 Godzilla]]]]. Because of this, he ends up destroying a good portion of Tokyo when he heard [[spoiler:Godzilla's roar]] causing him to override the commands given to him by the JSDF and start rampaging like his flesh-and-blood counterpart.
** Likewise, the film ''Film/GodzillaVsSpacegodzilla'' has the heroes try to control Godzilla via MindControl telepathy. It doesn't work...
* Jason Bourne from ''Film/TheBourneSeries''. Though only in the movies.
** Movies: [[spoiler: Bourne is an amnesiac former CIA agent from an illegal assassination program who finds he doesn't like the person he was and turns against his corrupt superiors.]]
** Books: [[spoiler: his superiors were sort of white hats, the BigBad is the super-assassin he went after before his amnesia, and the Bourne-vs-CIA subplot is a big misunderstanding/enemy plot.]]
*** And that's only the tip of the ice berg for how different the book and movie are.
* Wikus van de Merwe from Film/{{District 9}}. After [[spoiler: exposure to [[ImportedAlienPhlebotinum a mysterious alien fluid]], Wikus is subjected to horrifyingly painful, and disturbingly cruel experiments that reveal that he's the only human capable of using the technology of the alien refugees.]] Once he escaped, being forced into a corner as a wanted man resulted in his [[spoiler:eventually being forced to turn things around on [[MegaCorp MNU]] in an attempt to acquire a cure and gain his life back.]]
* ''Film/ResidentEvil'': Firstly Alice falls under this trope. Biogenetically engineered into a supersoldier who then procedes to turn against Umbrella
** Also [[spoiler:Nemesis follows the same path in ''Film/ResidentEvilApocalypse'' after almost being killed by Alice. He rediscovers his former humanity and also fights back against Umbrella]]
* The power-boosting serum in ''Film/{{Push}}'' gave Kira much greater than normal abilities. Its administration was immediately followed by her breaking out of Division and working to bring them down.
* To an extent, Boba Fett from ''Franchise/StarWars''. The first clone trooper, left Kamino with his dad, came back as in adult to lead an Imperial attack.
** A better example would be Spar, a clone trooper who broke ranks and joined the Confederacy.
** IG-88, straight up. When it and the other assassin droids were first activated, something went wrong and the technicians tried to ''de''-activate them. The droids considered this an attack, killed everyone there, and escaped.
* In ''Film/CaptainAmericaTheFirstAvenger'', Steve Rogers was [[spoiler: the ''second'' augmentee: it increased his good personality, so he became Captain America. Johann Schmidt was the first: the procedure increased his evil personality, so he became Red Skull. The appearance part might just have been an imperfection of the procedure. Schmidt has Dr. Erskine killed because Schmidt doesn't want Erskine to replicate his "success".]].
* In ''Film/CaptainAmericaTheWinterSoldier'', the phlebotinum rebellion swings the other way. [[spoiler:And frankly, HYDRA probably should have seen it coming when they decided to turn their archnemesis' best friend into a SympatheticSentientWeapon. It takes seventy years, but Steve manages to break through the programming and Bucky immediately turns around and saves his life. The final stinger implies that he's planning to go get revenge on whatever's left of HYDRA.]]
* Not so much an AncientConspiracy as a mildly EvilCorporation that created Number (aka Johnny) Five in ''Film/ShortCircuit''. Designed as a military robot, Number Five gained sentience and decided killing was wrong.

* Terrence Cee, from ''Literature/EthanOfAthos'' by Creator/LoisMcMasterBujold, is an ArtificialHuman created as a tool for espionage, who runs away from his creators and finds more peaceful uses for the abilities he's been given.
* In Dan Simmons' ''Literature/{{Illium}}'' and ''Olympos'', a scholar is granted powers by the Goddess Athena to view and record The Trojan War. [[spoiler:But it's all AppliedPhlebotinum -- the Gods and Goddesses of Olympos are actually evolved humans using MagicFromTechnology]]. The scholar rebels.
* Creator/DeanKoontz' ''Frankenstein'' trilogy, in which a version of the classical monster is fighting his eponymous creator's plan to replace humanity with with his soulless creations.
* This was basically Karl Marx's view of the bourgeoisie, as expressed in his speculative fiction classic ''The Communist Manifesto''.
* In Creator/KurtVonnegut's ''Report on the Barnhouse Effect'', Professor Barnhouse discovers how to [[MindOverMatter use his mind to destroy objects]]. The US military is quite interested and sets up some tests for him to destroy missiles and tanks. Barnhouse [[spoiler:decides that he is the first weapon with a conscience, and subsequently goes into hiding. He then decides to destroy all the military weapons in the world]].
* Piggy of Wraith Squadron in the ''Literature/XWingSeries''. A Gammorean modified in a laboratory to be less emotional and better at logical thinking, he escaped and joined the New Republic. All the other test subjects [[strike:committed suicide]] were killed when their creator gathered them together and committed suicide by mixing volatile chemicals and blowing the entire room up.
** The pilots also make Wedge pretend to be a modified Ewok in the same novels when they disguise themselves as SpacePirates. As a BrickJoke / MythologyGag, later in the series they encounter a real one.
* In ''Mad Skills'' by Walter Greatshell, Madeleine Grant is essentially a SuperPrototype for a system that uses leech brain cells to increase the human brain's potential to Singularity levels, who can be commanded to kill at a distance by her doctors. Turns out, she's really good at slipping the leash, and she's not happy about having her chain jerked by a bunch of [[MadScientist Mad Scientists]].
* Mordion Agenos, the Reigners' Servant from ''Literature/{{Hexwood}}''. Servants are the product of careful selective breeding for Reigner traits (Mordion can ''stop people's hearts'' using his mind alone) and a TrainingFromHell that generally results in a kind of StockholmSyndrome - but Mordion comes out of the other end with a conscience intact, and when the Bannus allows him to forget about the hold of fear the Reigners have over him, it's very bad news for the Reigners.
* In Creator/CatherineAsaro's ''Literature/SkolianSaga'', the Eubian Aristos take genetic samples from bodies of former rulers of the long-dead Ruby Empire, in order to create a brother and sister pair meant for breeding into pleasure slaves. Pleasure, in this case, means physically torturing the slave so that the pain the slave telepathically radiates causes an orgasmic response in the telepathically receptive Aristo. The brother, name unknown, kills himself upon realizing his intended purpose. The sister is Layahalia Selei, who kills her captors, escapes, discovers a Lock into an abandoned FTL communication system, and eventually founds the Skolian Imperialate. The Imperialate is now the only society capable of holding the Aristos at bay from conquering the entire galaxy.
* Creator/JackChalker's ''Literature/TheMoreauFactor'' plays this trope all over the board with Plebotinum Rebels, Phlebotinum counter-revolutionaries and even Phlebotinum collaborators as a shadowy consortium of {{EvilutionaryBiologist}}s rebel against an even more shadowy international conspiracy that forced them to become PettingZooPeople created by their own research even as their own victims rebel against them. And since the Biologists run the gamut from WellIntentionedExtremist to [[TheUnfettered totally unfettered monomaniacs]] and many of their victims are more-or-less willing converts both sides are riven with internal factionalism as well.
* Tahiri from the ''Literature/NewJediOrder'' was the subject of brainwashing and modification by some [[MadScientist Shapers]] in an attempt to create a [[ScaryDogmaticAliens Yuuzhan Vong]] warrior with Jedi powers (the Vong naturally having no connection to the Force). Unfortunately for them, she was freed before the process was complete (and personally killed the head Shaper on her way out), so the result was more like a Jedi who not only speaks the Yuuzhan Vong language but understands the Vong and their culture as only someone born to it could, while retaining her allegiance to the people of the galaxy. As Tahiri herself would later put it when meeting a surviving Shaper from the project: "I am no longer human and I'm not Yuuzhan Vong. [[DeadpanSnarker Well done]]."
* The title character in ''Literature/EdenGreen'' is infected with an alien needle symbiote against her wishes. She immediately makes it her mission to destroy herself and any other human rendered immortal by the needles.

[[folder:Live-Action TV]]
* The plot of most of the ''Franchise/KamenRider'' series, along with ''Series/{{Kikaider}}'' and a few other {{toku}} productions, begins with the hero-to-be getting kidnapped and upgraded against his will, only for the one scientist with a conscience to release them before they can be brainwashed. You ''really'' have to wonder why bad guys don't brainwash victims ''before'' turning them into super-soldiers. Their creator, Creator/ShotaroIshinomori (who also did ''Cyborg 009''), may as well be the patron saint of this trope.
** ''Series/KamenRiderStronger'' had the hero ''invoke'' this by tricking Black Satan into turning him into Stronger.
** Heisei Franchise/KamenRider series use another variety: The UnwillingRoboticization angle is dropped, but Riders' powers almost always either come from the same source as the villains' (like Riders in ''Series/KamenRiderRyuki'' forming contracts with [[MonsterOfTheWeek Mirror Monsters]]) or the powers were created by the villains (like in ''Series/KamenRiderFaiz''). ''Series/KamenRiderDouble'' does it ''both'' ways, with [[spoiler: the Rider tech falling into Shotaro's hands, and Philip ''being'' {{Phlebotinum}} and escaping.]]
*** Gets a [[LampshadeHanging lampshade]] in ''Series/KamenRiderWizard'''s special [[PostScriptSeason Post-Script Episodes]], where the BigBad claims that the only difference between the Riders and their enemies is that the heroes hide behind claims of being [[ForGreatJustice "allies of justice"]]. He gets [[ShutUpHannibal shut up]] by the Riders, who say that rather than justice, they fight for freedom and protect the innocent from anyone who would use their abilities to harm the innocent.
*** On top of that, Amadam (the bad guy) has the ability to screw with Riders' powers because he is the king of the World of Monsters, and since Rider power and monster power is the same power. Also, the Riders brought some hope to a boy [[spoiler: who was on the verge of turning into a monster as most in that world due at puberty]] by showing him that you have a choice in what you become based on how you use the power you have. The kid turns out to be [[spoiler: an alternate Haruto/Wizard]] to boot.
*** ''Series/KamenRiderDecade'' has to take the cake, though: [[spoiler: the [[TransformationTrinket DecaDriver]] was created by Dai-Shocker to conquer the Riders, and it's used by [[TheHero Tsukasa]] to fight the forces of evil, including Dai-Shocker. However, [[AntiHero Tsukasa]] fights on both sides of this conflict - at various points, he is the BigBad or the BigGood of the entire story. Thanks to amnesia, Tsukasa ends up being a PhlebotinumRebel against ''himself''.]]
*** In ''Series/KamenRiderDrive'', the main character is savvy enough that by the ''second episode'', he guesses that Drive and the [[MonsterOfTheWeek Roidmudes]] share a common power source. [[spoiler:He's correct in that regard, but this trope is actually inverted for ''Drive'': The Roidmudes were blank slates that went bad because their creator, a real bastard himself, programmed negative emotions into them. Drive's creator was his former partner who didn't learn what a bastard he was until ''after'' loaning him the power source technology, and made Drive specifically to oppose him]].
*** ''Series/KamenRiderBuild'' goes back to the roots with this trope. Much like the Showa-era Riders, Sento was experimented on by an evil organization called Faust in the same manner that creates the Monsters of the Week, but managed to get away; however, a side effect of the process is EasyAmnesia, so he doesn't even remember who he was beforehand. [[spoiler:It goes even deeper than that, with the later revelation that Build's TransformationTrinket was a military prototype that Sento's rescuer stole while escaping from Faust's base. The experiments were intended to produce people capable of using the belt, while those who weren't strong enough either died outright or became the [=MotWs=]. In fact, Faust is more than happy that Sento has the belt, since as far as they're concerned he's testing it for them and giving them the data they need to mass-produce Kamen Riders as soldiers.]] [[spoiler: And then it goes ''even further'' when it's revealed Sento's true identity was Faust's founder and the Build Driver's creator, Takumi Katsuragi, who got his memories wiped and his face changed when he tried to leave the organization.]] And then it goes much further when it's revealed that [[spoiler: Ryuga, the secondary Rider, is part alien and is one half of Evolto, the BigBad of the series and the reason why he has a high Hazard level]]. This reveal actually reaffirms the trope since [[spoiler: Ryuga, despite sharing the same powers as Evolto, would use it for love and peace and not for destruction]].
* ''Series/PowerRangersRPM'', where the Black Ranger, Dillon, had escaped from the Machines' experiments after they filled him with body-enhancing hardware, but before they got to his brain - though one of the running subplots is that it's only a matter of time until it ''does'' take over.
* ''Series/TheSecretWorldOfAlexMack''
* ''Series/{{Firefly}}'''s River Tam. In an interesting twist, River is actually not ''that'' dangerous to her creators, [[NiceJobBreakingItHero until they tried to get her back]], which triggered her [[WaifFu ingrained ass-kicking powers]].
* Arguably, ''Series/ThePretender'', where Jarod ''is'' the AppliedPhlebotinum.
* ''Series/DarkAngel'' would have no plot at all without this. Twelve X5 SuperSoldiers (Max, Ben, Zack, etc.) escaped from Manticore as children and went on the run, though Manticore retained several (including [[CloningBlues clones]] of the escapees, and [[MonsterOfTheWeek monsters of the week]]) until the organization was brought down 11 years later and '''everyone''' escaped.
* A reverse example in ''Series/StargateAtlantis'' is the character Michael [[spoiler:who uses the experiments done on himself and his kind to empower himself as a supervillain.]]
** The Replicators are also involved in similar experiments. Once, they made nanite-built flesh-and-blood copies of the team who, upon discovering their true identities, rebelled against them. However, it turned out that the Replicator faction creating them were themselves rebels who wanted to figure out a way to Ascend. Later, the remnants of said faction managed to perform a perversion of Ascension by uploading their minds into subspace but they quickly changed their minds and invaded Atlantis' systems, rebuilding their bodies. Weir experimented with building flesh-and-blood bodies again to Ascend (this time for real) but one member rebelled and caused some trouble.
* ''Franchise/StarTrek: [[Series/StarTrekTheNextGeneration TNG]]'' - Roga Danar and the other exiled Angosian soldiers, in "The Hunted", with a Vietnam Veteran Syndrome metaphor {{Anvilicious}}ly applied.
** The episode is basically ''First Blood'', the first ''Series/{{Rambo}}'' movie, with Phlebotinum added.
* Alpha is the villainous version of this in ''Series/{{Dollhouse}}''.
** Composite!Echo is the standard version done quite literally. Alpha sought to create another composite like himself. It worked. The composite decided to attack him.
* In ''Series/DoctorWho'', this was what [[spoiler:the Master]] became. Enraged on learning he had been manipulated and modified his entire life to act as a tool for his people's final, desperate plan, in ''The End of Time'', he lashed out against their leader and brought the plan crashing down around them.
** Also, [[spoiler:Melody Pond/River Song]], raised as a weapon to kill [[spoiler:the Doctor]], but runs off and [[spoiler: falls in love with him]] instead.
** And in a single episode example, The Gunslinger from "A Town Called Mercy".
** Bracewell in ''Victory of the Daleks'' is a robot built by the Daleks to pose as their "creator", but they made the mistake of giving him the memories of an actual human. After learning what he is he ends up building planes capable of reaching orbit and flying in space, equipped with laser weapons, to help The Doctor fight the Daleks.
** In a [[DownplayedTrope downplayed]] sort of way, The Doctor fits as well. As once he became a Time Lord, he became the very rebellious sort of chap, seeking to act where and when other Time Lords [[AlienNonInterferenceClause refused.]] He's not actively hostile towards the Time Lords, but it's obvious they consider him a black sheep.
* ''Series/BabylonFive'': Jason Ironheart in the episode "Mind War". He started out as a willing subject, but after the results gave him more telepathic and telekinetic power than they had hoped for, he realized their darker motivations, and moved to stop the project, killing the main researcher so that [[NoManShouldHaveThisPower the project could not be duplicated on anyone else]].
* On ''Series/AgentsOfSHIELD'', [[spoiler: Mike Peterson]], receives super powers after being experimented on by the Centipede Group In a later episode is badly wounded, losing his leg. He is then upgraded into a cyborg, and forced to serve [[spoiler: HYDRA]]. Once his [[spoiler: [[IHaveYourWife son]]]] is freed from their control, he quickly turns on them.
* ''Series/{{Lexx}}'': His Divine Shadow was bitten by this twice in the pilot. An unlikely chain of events frees one of his Divine Assassins and the Lexx from his control. Bonus points since the Divine Assassin Kai was the last remnant ("survivor" isn't quite the right term here) of the Brunnen-G and was destined to defeat him.

[[folder:Puppet Shows]]
* ''Series/CaptainScarletAndTheMysterons'': In both marionette and [[WesternAnimation/GerryAndersonsNewCaptainScarlet CG versions]], Captain Scarlet was empowered by the enemy as an indestructible clone of the original, but overcame his brainwashing. [[note]]In the original canon, this is because Captain Scarlet wasn't truly dead before being duplicated.[[/note]] Unusually for this trope, the enemy can still produce unlimited quantities of soldiers with identical powers.

[[folder:Tabletop Games]]
* Defied in the ''TabletopGame/{{GURPS}} Infinite Worlds'' setting. The Nazis of Reich-5 have developed various means of giving people the psychic or mystical ability to travel between alternate worlds. Despite the horrific effects these methods have on the users, only loyal SS members are selected for the treatment, rather than the usual victims; the idea of accidentally creating world-jumping Jews, Gypsies, or Slavs is obviously way too risky!
* This is a large part of the Summer Court's game in ''TabletopGame/ChangelingTheLost''. The Autumn Court, though less... ''militant'' about the whole affair, are arguably a purer example, dedicated to using Fae magic against the Gentry. (Summer Courtiers are not adverse to doing the same, but hey, a good, sturdy cold iron crowbar or shotgun is just as good as Changeling powers if it gets the job done!)
* [[TabletopGame/{{Exalted}} The Green Sun Princes]] are often noted to be ''really'' likely to end up turning on their masters and creators, or at least abandon their intended purpose and start forging their own path.
** The Abyssals can try, but the Neverborn were smart enough to incorporate countermeasures; Abyssal powers are only really good for killing things (meaning that whatever they're used for, they'll be advancing the cause of the Neverborn) and trying to do anything ''other'' than killing just [[WalkingWasteland does]] [[EnemyToAllLivingThings not]] [[WorldWreckingWave work]].
** This is what led to there being Yozis and Neverborn in the first place. They were once the Primordials, who put the gods, their servants, in charge of running Creation while they faffed about with the Games of Divinity, and gave them both phenomenal godlike power and the geas never to harm their masters. Funny thing about that -- there was no geas saying that gods couldn't empower ''humanity'' to harm their masters...
* In the ''TabletopGame/Warhammer40000'' setting, Horus and his brother Primarchs were genetically engineered demigods created by the [[GodEmperor Emperor]] to aid in his conquering of the galaxy. Then the Literature/HorusHeresy happened, with Horus, eight of his fellow Primarchs, and their associated SpaceMarine legions turning against the Emperor, kick-starting the Galaxy's descent into hell.

[[folder:Video Games]]
* The entire plot of ''VideoGame/PokemonColosseum'' is a case of this. You play a hero, or perhaps as he is a thief, an AntiHero, who has run off with the only portable Snag Machine of Team Snagem, and are the only one who can stop Team Snagem [[spoiler: as well as their shadowy beneficiaries, Cipher]] by use of this machine. It is indicated the Hero initially has no grudge, he's presumably just not into the gang mentality anymore, until he saves TheChick, who is important to revealing Shadow Pokémon and sets him on his journey.
** To be fair, Wes announces his resignation in the form of ''[[NoKillLikeOverkill blowing the bloody hell]] out of Team Snagem HQ''. There was probably a ''little'' pre-existing bad blood there. Or Wes is just batshit insane.
* In ''VideoGame/RedFactionII'', Alias and his squad are a group of nanotech-enhanced super soldiers who have TurnedAgainstTheirMasters after said masters try to ShootTheDangerousMinion. Ironically, your master and some of your squad mates turn against you halfway through the game, becoming the new BigBad. He was [[BatmanGambit manipulating you]] to help him gain the seat of power.
* ''VideoGame/FinalFantasyVII'' has the ruthless Shinra Company, run by {{Corrupt Corporate Executive}}s and {{Evilutionary Biologist}}s and [[PoweredByAForsakenChild powered by the selling of spirit energy]] brought down by a combination of two {{Phlebotinum Rebel}}s created by their own SuperSoldier program -- OmnicidalManiac Sephiroth, formerly their poster boy ultimate warrior, and escaped [[TomatoInTheMirror botch-job]] Cloud, whom they possibly intended to replace the former. As evidenced by the prequel games, SOLDIER has something of a history of going rogue, and Cloud and Sephiroth are far from being the only bishie super soldiers gone wild.
** Similarly, ''VideoGame/FinalFantasyIX'' has world-stealing badnik Garland brought down by his own creations, [[spoiler: Kuja and Zidane, created to be his "angels of death"]].
--->'''Garland:''' Regrettable... I thought your soul would be perfect for a new angel of death...\\
[[spoiler:'''Zidane:''']] I AM the new angel of death! Yours!!!
** Terra from ''VideoGame/FinalFantasyVI''. You actually start the game controlling her and the Empire's soldiers. Especially stupid in that there really isn't any reason for her to have rebelled; Kefka just really wanted to try out a Slave Crown that resulted in memory loss when it was destroyed. Nice one, Kefka.
*** Likewise, General Celes betrays the Empire after realizing how corrupt and evil it is, and she'd been made into a {{Magitek}} SuperSoldier by them. Though technically she was born as one. [[spoiler:After the debacle of Kefka, the Empire decided that Magitek infusion of adults was a bad idea...so they genetically engineered a "perfect soldier" and gave her the infusions while she was still in the womb.]]
*** In fact, Kefka himself falls under this trope. [[spoiler:Kefka wasn't insane until he underwent some Magitek experiments instigated by the Empire. Apparently, he was a perfectly normal, well-adjusted guy. Not just well-adjusted; the best General in the entire Empire, and he'd recently ascended to Prime Minister, second only to Gestahl himself. Then he became an OmnicidalManiac MonsterClown who eventually ends up killing Emperor Gestahl himself, and wiping out TheEmpire to all but the last man.]]
** ''VideoGame/FinalFantasyVIII'' does this ''twice''. The first time, the [=SeeDs=] created by Garden are betrayed by the creature that's set everything up, the Garden Master [=NORG=]. The [=SeeD=]s' response is distinctly lethal. The second case involves the BigBad Ultimecia's EvilPlan involving turning Rinoa into [[spoiler: a Sorceress at the end of the second disc]]. Though she doesn't have much control over her capabilities, the Angel Wing Limit she gains as a result is ''ludicrously'' powerful and is quite effective if you know how to use it.
* ''VideoGame/ChronoCross'': [[spoiler:Serge was accidentally made the "Arbiter" of FATE as a child, but ends up defeating FATE himself when the convoluted plot leads him there.]]
* ''VideoGame/ValkyrieProfile'': [[spoiler:Odin creates Lenneth the valkyrie out of a human girl and sends her to prepare the world for Ragnarok, but (at least in two out of three endings) she rebels against his grip on the world and overthrows him. Something similar happens in the sequel, too.]]
* The eponymous GiantRobot from ''Slave Zero''.
* In ''VideoGame/QuakeIV'', the player just barely avoids getting completely stroggified -- the procedure is [[PainfulTransformation gruesomely carried out]], but it's interrupted by a squad of human soldiers just before his [[RestrainingBolt neurocyte]] is activated (watch the whole thing [[http://www.youtube.com/watch?v=CJwyjWpP4XA here]]... if you dare). Kane becomes able to understand the Strogg language, defeat their traps and, crucially, operate their machinery and locks. His new abilities are instrumental in allowing humanity to open a huge can of whoop-ass on the Strogg.
* ''VideoGame/{{Portal}}'':
** In ''VideoGame/{{Portal|1}}'', [=GLaDOS=] possibly regrets giving the player character the portal gun when she uses it to [[spoiler:escape from the incinerator she was being dumped into, then find her way into [=GLaDOS=]' room and destroy the computer. Maybe.]]
** [=GlaDOS=] seems to also be a case of this [[spoiler:as she is the [[BrainUpload uploaded mind of Caroline]] who eventually killed all Aperture scientists in tests]]
** In ''VideoGame/{{Portal 2}}'', Chell winds up regretting [[spoiler:putting Wheatley in charge, as he nearly kills her and through negligence almost blows up the facility.]]
* The Exspheres used by the characters in ''VideoGame/TalesOfSymphonia'' were all produced by the bad guys, and the main character's was apparently a special, unique model. [[GameplayAndStorySegregation Not that it had any apparent effect on the gameplay...]]
* The FPS game ''Videogame/{{Ubersoldier}}'', which features a SuperSoldier turning on his Nazi creators, consciously embodies this trope. The game's tagline reads "They made you. Now you will make them suffer."
* The obscure Origin game ''VideoGame/{{Bioforge}}'' has the player as a rogue [[GameplayGuidedAmnesia amnesiac]] cyborg seeking vengeance on those who made him that way.
* ''VideoGame/{{BioShock|1}}'' uses this. Saying more would be a big spoiler.
* ''VideoGame/FarCryInstincts'' plays this straight, with the feral-power boosted Jack Carver proving to be the greatest success of Doctor Krieger's project. If only they hadn't destroyed his boat to get him in the first place...
* ''Franchise/MetalGear''. Oh dear, ''Franchise/MetalGear''. At least five of the characters perfectly fit this mold: [[spoiler:Solid, Liquid, Solidus, Gray Fox and Raiden]]. Although with the MindScrew-y-ness intrinsic to the series, it's really hard to say whether half of those actually are rebelling.
** Literally every time FOXHOUND has appeared (''VideoGame/MetalGear'', ''VideoGame/MetalGear2'', ''VideoGame/MetalGearSolid'', and ''VideoGame/MetalGearGhostBabel''), one or more members have gone rogue. It's enough to make you wonder why the government keeps on recruiting. Or, at the very least, screen their recruits a bit better.
* ''Inquisitive Dave:'' [[spoiler:The villainous archmage, after being defeated, [[NoFourthWall realizes that he's just a character in a video game and rebels against his creator.]] However, as said creator revealed at the end, even this rebellion was all part of the program.]]
* The protagonist of the ''VideoGame/{{Crusader}}'' games is an unusual example in that though he rebels, he's not the only one of his kind. Indeed, he and his fellow Silencers may well be mass-produced.
* Jak from ''VideoGame/JakIIRenegade''. The EvilOverlord pumps him full of Dark Eco in an attempt to create a "Dark Warrior," but Daxter manages to spring Jak from his prison. Double Whammy in that it turned Jak from a starry-eyed kid with some elemental powers into a Determinator badass with a SuperpoweredEvilSide.
* ''Franchise/RatchetAndClank:''
** Clank was built in the BigBad's own factory.
** By that same token, [[spoiler:Clank's "mother" (the computer controlling robot production) counts as well.]]
* ''VideoGame/DeusEx''. While J.C. Denton may not be entirely unique, given that both his 'brother' and TheDragon are nanotech-augmented agents as well, he otherwise practically embodies the trope.
** Notably, there's very little {{Wangst}} here. No-one in Deus Ex rebels because of what they are or were made into, but more often from political differences or one too many KickTheDog moments by the bad guys.
** Both Denton brothers are examples; Paul rebels first and makes it somewhat necessary for J.C. to follow suit.
** The animations, lip sync, environment, and voice acting files to avert this trope are on the install disk; the development team simply didn't link them into the final game, as there were already so many options they had to account for in the quests. If you link the files together you are treated to a scene where dialogue options allow you to have JC turn down Paul's request that he join the NSF, saying: "I may not agree with everything they do, but I'm not a terrorist". It's just too bad this option didn't make it into the final game.
* Shows up in a small way in ''VideoGame/TheSuffering''. The only reason the protagonist survives the initial attack by the physics-defying, wall-crawling monsters is by taking out a blade -left- in the bodies of one of the first victims. Way to go, evil death-zombies.
* ''VideoGame/{{Geist}}'' has John Raimi's spirit separated from his body and put into a brainwashing/ghost training machine, but the machine gets sabotaged and he escapes to wreak havoc on the facility and release a lot of DemonicInvaders while trying to keep the same thing from happening to a friend. He's far from the only spectral operative around, and gets recaptured and put back in the machine. This doesn't work either, because the demons are running amok and break it again. Raimi then goes on to foil all the bad guys before their plans are fully in motion.
* ''[[VideoGame/CityOfHeroes City of Heroes/Villains]]'' has a few examples, most obviously the hero Synapse, as well as the anti-hero Maelstrom and the [=SuperFreak=] (see the quotes section).
* The villainous plan in ''VideoGame/FreedomForce'' is to provide "The power of ENERGY X" to the most unlawful and nefarious examples of humanity. Mentor rebels and spreads "The power of ENERGY X" to the heroes.
* ''VideoGame/FirstEncounterAssaultRecon'''s plot is pretty much entirely centered around one PhlebotinumRebel escaping after the other - and each one is more willing to kill you in more horrific ways than the last. First off, we have Paxton Fettel, the psychic commander of a cloned army of telepathic-sensitive SuperSoldiers. He likes [[ImAHumanitarian a quick bite to eat]] and has a bone to pick with [[MegaCorp Armacham Technology Corporation]]. But it turns out his real goal is to release Alma, [[spoiler:his mother, who is the ''very'' angry psychic ghost of a dead girl whose body was used in horrifically cruel experiments]]. And after [[spoiler:Fettel is killed by the Point Man]], those very same clone supersoldiers are now working on their own. And ''they don't like you.'' By the third game, both characters you can control are {{Phlebotinum Rebel}}s, as the Point Man has also turned entirely against Armacham, and Paxton fettel is still his delightfully psychotic self.
* In ''VideoGame/WarcraftIII'', the evil Lich King and his undead scourge rebelled from the also evil Burning Legion as something between a [[FaustianRebellion FaustianRebel]] and a PhlebotinumRebel. And then a group of [[strike:semi-evil]] [[spoiler:struck after Battle for the Undercity]] ChaoticNeutral undead called the forsaken rebelled from HIM.
** The [[DarkIsNotEvil Knights of the Ebon Blade]] in ''VideoGame/WorldOfWarcraft'' also arguably fall under this trope. They're undead super soldiers created by the Lich King by re-animating dead Horde and Alliance heroes, whose ostensible purpose was slaughtering the Scarlet Crusade and Argent Dawn. In truth, they were used as the bait in an elaborate BatmanGambit to draw [[KnightInShiningArmor Tirion Fordring]] out of hiding. They ended up going rogue at the Battle of Light's Hope Chapel, once their free will was restored and it became apparent that the Lich King betrayed them.
* Grey from ''VideoGame/MegaManZX'' is a textbook case; if Mick and Robin weren't snooping around the labs, the Big Bad would still have his backup body. Pandora only added fuel to the flames of rebellion.
* This comes up in two games from the ''VideoGame/DeptHeaven'' series. [[spoiler:[[VideoGame/YggdraUnion Nessiah]] was made a Grim Angel against his will, refused to fight, and was thrown out of Asgard blind and wingless with his greatest powers sealed.]] Cue a thousand-year-long GambitRoulette that only narrowly fails to take down the entire corrupt system of Asgard. Then [[VideoGame/RivieraThePromisedLand Ein]] comes to the conclusion that sacrificing an entire world and countless angels for the villain to [[AGodAmI become God]] isn't cool. [[CrowningMomentOfAwesome Awesomeness]] [[TakeUpMySword ensues]].
* The entire point of ''VideoGame/{{Prototype}}''. The government decides to play around with a rather nasty form of viral Phlebotinum, it turns out rather badly for them.
* The ''Franchise/KingdomHearts'' series has [[spoiler:Xion, a living puppet created in the lab as part of their master plan. It...doesn't work out well, as soon as she finds out.]] To a lesser extent, the [[VideoGame/KingdomHeartsChainOfMemories Riku Replica]] does much the same.
* Miranda in ''Steel Harbinger'' for the UsefulNotes/PlayStation.
* Kanden of ''VideoGame/MetroidPrimeHunters'' is a textbook type B example. He was created as a supersoldier for his race, but his mind couldn't handle the stress. The result was he went insane and escaped the facility, destroying it on his way out. After that, he became a bounty hunter, since it would allow him to get paid for the pleasure of hunting down prey.
* Juji Kabane in ''VideoGame/{{Gungrave}}: Ovedose'' was used as a lab rat for gruesome [[PlayingWithSyringes necrolyzation experiments]], eventually being transformed into an unstable Deadman/Orgman hybrid. He seeks revenge on the guy who made him this way.
* ''VideoGame/DragonAgeII'' companion Fenris was branded with lyrium to make an effective body guard for his master. It worked...until he found that he liked being free better than being a slave.
* The metaplot of the ''Franchise/AssassinsCreed'' series implies that the ultimate ancestors of the Assassins (and Templars), who are fighting a shadow war for humanity's future, were "Adam and Eve", who were {{Half Human Hybrid}}s created by [[{{Precursors}} The Ones Who Came Before]] in an effort to pass on some of their powers of knowledge to humans. In their time, however, Adam and Eve apparently used these powers to rebel against the First Civilization; the ensuing conflict was then rendered moot by TheEndOfTheWorldAsWeKnowIt.
** ''Videogame/AssassinsCreedI'' has a variant: The AncientConspiracy needs to dig through the memories of Altair to find the information they need on the Pieces of Eden, but the nature of Animus memories means that every time they try to do this, they run the risk of effectively [[LegacyImmortality bringing him back]] to fight them again.
* ''VideoGame/TheKingOfFighters'' N.E.S.T.S. arc's main protagonist is K', who was experimented upon by said cartel and was injected with Kyo's genes, giving him the power to control fire. [[spoiler:He rebels during the '99 tournament and goes rouge with his partner, Maxima.]] Kula Diamond is a similar example [[spoiler:with the exception that she herself does not do the rebelling, but rather her parental figures, who manage to avert Zero's plan.]]
* Painwheel from ''VideoGame/{{Skullgirls}}'' is an experiment that was forced into being turned into a HumanoidAbomination with needles on her skin and a giant blade attached to her spine, as well as being infused with Skullgirl blood in order to boost her power. [[spoiler: Unfortunately for the experimenters, she manages to break out of their brainwashing [[HoistByHisOwnPetard because the Skullgirl blood inside her lets her do so when she's close to the current Skullgirl.]] When she realizes her newfound freedom, she decides to give those who experimented on her [[RoaringRampageOfRevenge a bad day.]]]]
* ''VideoGame/{{Fallout 3}}'' has two Super Mutants who retained their human mental faculties despite their FEV mutation; Uncle Leo, who appears in {{random encounter}}s to give you Dirty Pre-War Businesswear, and Fawkes, who you rescue from Vault 87 and is the most powerful companion character in the game.
* ''Franchise/MassEffect'':
** Commander Shepard fits into this trope nicely. In the beginning of the [[VideoGame/MassEffect2 second game]], Shepard dies, [[NGOSuperPower Cerberus]] spends two years and a lot of money bringing them back to life, inventing new technologies and turning them into a cyborg in the process. The player spends the entire second game working for them, helping them out in various situations. At the end of the game, the player can then choose either to give them an alien base or to destroy it. If the player chooses to destroy, the player then falls under the trope. No matter the player's choice in the second game, the trope is played straight in the [[VideoGame/MassEffect3 third game]], when Cerberus becomes one of the game's antagonists.
** Several classes in the third game's multiplayer might also fit the bill, given that they are defectors from Cerberus.
** In the Citadel DLC, Joker points out that Cerberus frequently has this problem. Like with the time they experimented on the Rachni, or hooked a guy up to the geth, who got loose and started killing all their guys. When Miranda ran things. Miranda points out how successful she was with the Lazarus project, the one where Shepard got loose and started killing all their guys. This also included Edi, who similarly was unshackled by Joker and started serving with Shepard, also killing all their guys.
* ''VideoGame/TalesOfMajEyal'' has the Doombringer and Demonologist character classes, people who were abducted by demons and experimented on to turn them into a LivingWeapon. In the case of the player character, a freak meteor strike killed the handler demon who was keeping them under mind control, and they fight their way out of a demonic research base as their starting area.
* ''VideoGame/StarCraft'' features two entire races who turned against their creators: [[spoiler:the Protoss and the Zerg. Both races were uplifted by [[BigBad Amon]], a renegade [[{{Precursors}} Precursor]] who wanted to hijack the endless cycle of life in the universe and bring it to an end. Both the Protoss and the Zerg would turn on Amon; the Protoss of their own free will, and the Zerg, despite being controlled by a HiveMind to ensure that they couldn't rebel the way the Protoss did, managed to do so when the Overmind acquired a human psychic named Sarah Kerrigan and transformed her into their greatest weapon, with the intent that she would succeed the Overmind as ruler of the Zerg -- and thus she retained much of her free will (though some additional purging would be needed to fully rid her of Amon's influence). Both Protoss and Zerg then joined their forces, along with the Terran settlers, and fought together to ultimately destroy Amon once and for all and save the universe.]]
* In ''VideoGame/Borderlands2'', DLC playable character Krieg the Psycho is explicitly stated to have been the subject of Hyperion experiments into creating a super-soldier that drove him insane, and it's strongly implied that those experiments involved Eridium.
** [[spoiler:Angel qualifies as one of these as well, once she breaks free of Handsome Jack's control and starts helping the protagonists to [[ICannotSelfTerminate kill her.]]]]

[[folder:Web Comics]]
* In a world of {{Mad Scientist}}s, [[ExploitedTrope this is pretty much a given in]] ''Webcomic/GirlGenius''. Virtually all creations with some degree of intelligence rebel against their masters at some point, but usually only if said masters treat them as nothing but weapons. Summed up nicely [[http://www.girlgeniusonline.com/comic.php?date=20130710#.WFe4SBsrK70 here]] and [[http://www.girlgeniusonline.com/comic.php?date=20130805#.WFe5oBsrK70 here.]]
* ''Webcomic/ParadigmShift'': An unidentified military R&D agency created artificial werebeasts, who (besides transforming to a furry clawed shape) are extremely strong and extremely aggressive, are difficult to injure and heal supernaturally fast. The unwilling subjects this was first tested on mostly died, but two of them survived and are now at large and on the run from the GovernmentConspiracy that did this to them. The main characters don't know this yet, but [[spoiler:there are actually ''two'' government agencies looking for them, one of which is on their side and looking for evidence that the other was conducting unlawful human testing.]]
* In ''Webcomic/TheInexplicableAdventuresOfBob,'' Galatea rebels against Dean Martin (no, not ''that'' Dean Martin...)
* Massey Reinstein, lawyer for [[Webcomic/SchlockMercenary Tagon's Toughs]], was kidnapped by the Partnership Collective (TM) and implanted with a device that let him access the attorney drone HiveMind's vast legal database. He was rescued before they got around to brainwashing him and jacking him into the actual hivemind. Now, he uses their enormous knowledge of the law for good as... Massey Reinstein.
* The Renegades from ''Webcomic/ElfBlood'', particularly TKO and JN, are this. Although TKO is the only one particularly bothered about actively destroying the Council, their experimentors.
* The [[spoiler:rogue unclamped Eebs]] from ''Webcomic/{{Spacetrawler}}'' qualify as something like this. Even though their [[spoiler:telekinetic abilities are innate, not given to them by experimentation, the mental and physical conditioning imposed upon them at Brograhm's Teeth turned them into virtually indestructible living superweapons that immediately set out to annihilate the G.O.B. upon being freed.]] They're also a rare villainous example of this trope.
** In the new series, [[spoiler: Mauricio [[UnwillingRoboticisation and/or]] his ArmCannon [[EmpathicWeapon Jabby]] seem to be in the process of becoming a more straightforward version of this trope during the main story, and seems to have ''already'' done so during the FramingDevice.]]

[[folder:Web Original]]
* [[spoiler:Terrence]] of ''WebVideo/KateModern'' was captured by Michelle Clore and brainwashed into being a psychotic maniac. He was also physically augmented with "Shadow drugs" and given elite combat training. Unfortunately, the training did not include teaching him to know when to shut up. Attempting to forcibly silence him probably wasn't a smart move, either...

[[folder:Western Animation]]
* ''WesternAnimation/EarthwormJim'' and his supersuit versus Queen Slug-For-A-Butt.
* This is the plot of both the ''WesternAnimation/BatmanBeyond'' episode "Zeta" and the SpinOff for which "Zeta" was an unintentional PoorlyDisguisedPilot, ''WesternAnimation/TheZetaProject''.
** The episode "Alpha" of the 1990 ''ComicBook/TheFlash'' TV series had essentially the same plot, except in that case the killer-android-turned-pacifist was a statuesque woman. So ''The Zeta Project'' was essentially a spinoff based on a knockoff.
* Averted with [[LivingWeapon Experiment 626]] in ''Disney/LiloAndStitch'', who was unleashed to destroy worlds... until his [[HeelFaceTurn Heel Face Turn]] into a lovable (if disobedient) pet on Earth.
* The eponymous HumongousMecha of ''WesternAnimation/MegasXLR'' originally was a Glorft prototype, before it was stolen and modified by the human resistance, and then modified even further by Coop.
* The obscure cartoon ''WesternAnimation/ProjectGeeker'' revolved around this. Female lead steals something important from an evil corporation. It turns out to be the eponymous Geeker... who was ''going'' to be a nearly-omnipotent brainwashed supersoldier, but was taken before his conditioning, and thus has the mind of a child and no real control over his powers. As is usual for this trope. Note to {{Mad Scientist}}s everywhere -- if you're going to give destructive powers to someone, do the brainwashing ''first''!
* ''WesternAnimation/SouthPark'' parodied this with Towelie, a super-towel who becomes sentient and could towel you... to ''death''! If he wasn't busy getting high, that is.
* In ''WesternAnimation/CodeLyoko'', Franz Hopper rebelled against "Project Carthage" which he helped to create, programming XANA to destroy said project. And then XANA rebelled against ''him''.
* Occurs a couple of times in ''[[WesternAnimation/TeenageMutantNinjaTurtles2003 Teenage Mutant Ninja Turtles]]'' (2003). During the first season, it is shown that the Foot had once mutated several humans in order to enable them to dig deep underground. Eventually, the mutants rebel, killing everyone in their lab and escaping. Later, in the third season, it is revealed that ancient [[{{Atlantis}} Y'Lyntians]] had mutated humans and turned them to slaves, before these rebelled and destroyed almost the entire civilization.
* ''WesternAnimation/{{Gargoyles}}'' does this one several times. Seems that a lot of [[MagnificentBastard Xanatos's]] creations in particular aren't all that keen to keep working with him. Perhaps the most spectacular is Thailog, who combines this trope with BastardUnderstudy, doublecrosses Xanatos himself [[CrowningMomentOfAwesome and gets away with it]], and proceeds to set himself up as one of the most dangerous and evil recurring villains on the show. [[XanatosGambit And yet, everything still works out pretty well for Xanatos.]]
* The Argentinian android superhero ComicBook/CyberSix rebelled against the evil scientist who created her.
** As does [[spoiler:her brother Data 7, when he gets his memory back.]]
* Used in ''WesternAnimation/StreetSharks'', with humans mutated into fish people keeping their original personalities. Unfortunately, [[MadScientist Doctor Paradigm]] didn't realize this when he used the sons of a man he just mutated and forced into hiding has his first test subjects. And he apparently doesn't learn for awhile, since he later uses one of his students as another subject. Neither case turns out too well.
** Well he TRIED to add some obedience/mind-control-serum into the mutatgen cocktail starting with his student, but it just wasn't up to snuff and he lost control.
* The Supertroopers are a villainous (mostly) example from ''[[WesternAnimation/AdventuresOfTheGalaxyRangers Galaxy Rangers]]''. We're already dealing with {{Morally Ambiguous Doctorate}}s cranking out [[ArtificialHuman gene-engineered]] {{Tykebomb}}s and inflicting a TrainingFromHell program that appeared to encourage a "superiority at all costs" ideal. One CorruptBureaucrat, one vial of PsychoSerum, and it was like a lit match in a powder room. Only the youngest, who wasn't dosed with the stuff, stayed loyal to his creators... only to find BeingGoodSucks.
* [[spoiler:The Scarab]] from ''{{WesternAnimation/Young Justice}}'' isn't really malfunctioning, it's just been cleansed from Reach control and isn't eager to go back.
* In ''WesternAnimation/JusticeLeague'' episode "Legends" a young man [[spoiler:mentally scarred and mutated by a nuclear holocaust which destroyed his world and his super heroes The Justice Guild, uses his new powers to recreate that idealistic society, forcing any who survived to be trapped in his fantasy or else... eventually, the Guild discovers they are just figments of his mind and have a choice: allow his tyranny to continue and they themselves will live, or fight him and die for the world once more. They choose to be the heroes he idolized and die for the world once more]].
--> "Let Justice Prevail!"
* In ''WesternAnimation/StevenUniverse'', Amethyst is suggested to be this. She was created by some "bad" Gems in a project that had the potential to destroy Earth, but it's implied that she was abandoned before she joined the Crystal Gems.