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"The line must be drawn here! This far, no further!"
Captain Picard, on The Borg.

In speculative fiction settings with very high technological levels, older Space Opera in particular, transhumans, meaning people who use cybernetic and/or genetic enhancements to give themselves capabilities far in excess of those of ordinary humans, will often be either completely absent or much rarer than you would expect given the stated capabilities of the society they live in. In the older works this was more a case of No Transhumanism Existing As A Distinct Concept Yet, though they did have Evolutionary Levels and/or Mutants which often served the same plot purpose. A primary contributor to Schizo Tech.

Oddly enough, Twenty Minutes Into The Future settings, particularly within the Cyberpunk genre, typically feature human capability enhancement prominently. This is probably caused by real-world technological advancements making it seem like this will become reality in the relatively near future, while older works hail from a period when this sort of thing still seemed entirely fantastic and authors therefore rarely included such themes in their stories.

Often caused by the fact that Most Writers Are Human: only a few authors dare try to imagine what a fictional society where everyone or at least the majority are no longer recognisably human would be like. Much easier, then, to have everyone be regular humans wielding nifty supertools rather than transhumans with nifty superbodies and superminds, which also conveniently allows the humans in the audience to relate to the characters better by keeping their thoughts, behavior patterns and limitations familiar. Also done to sidestep What Measure Is A Non Super: the idea that humanity might be "superseded" by a more advanced version is repugnant to many, and the more radical the enhancements are, the more likely it will be seen as a kind of Body Horror. Transhumans can end up as default villains in Space Opera settings, as it's all too easy to classify someone nonhuman as less-than-human. In that sense it's a form of Fantastic Racism, sometimes called bioism (prejudice against non-biological consciousness or modified life). Subtler but equally unsettling is the thought that not all humans are likely to be able to take advantage of genetic engineering and advanced cybernetics, and the gap between the "haves" and "have-nots" would naturally become even wider as rich people and poor people literally become separate species. In some cases, you will find that villains use radical modifications while the heroes remain more Badass Normal and "pure", leading to What Measure Is A Non Human.

This is sometimes justified or at least Hand Waved in various fashions; it could be a form of Schizo Tech where genetics and cybernetics stagnated while other scientific fields advanced, it might be considered unethical or be illegal, or there could be strong taboos in place due to past problems with this sort of thing. Instances of replacing lost body parts with equivalent or improved versions are not really an aversion, as the people of the society still do not seek out these enhancements (and especially so if the replacements aren't even more effective than the originals). A very specific form of Misapplied Phlebotinum. The most common aversion of this trope is the Super Soldier.

Often part of a Feudal Future's Back Story - excessive regulation and short-sighted bureaucrats are a serious threat to Real Life scientific development.

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