"Imagine you meet a magical leprechaun. For a bargain price, he offers to fix up the your house and add an extra room. So you take him home, and he proceeds to eat your house and shit out a hundred and forty more leprechauns, which promptly murder you."Grey Goo is like a Horde of Alien Locusts, only replace Alien Locusts with Nanotechnology or any other self-replicating material — and instead of grass, they "eat" anything. Or, if the protagonists are lucky, just anything mineral or electronic. They're worse than alien locusts. Grey Goo destroys resources by turning them into more grey goo — more nano machines or whatever matter the grey goo is composed of. It's The Virus for nonliving things — though it may be able to take down living things as well, and likely will turn them into nonliving things if they're in the wrong place (ie: outside). In theory, you can end up with a planetary body made of nothing but grey goo. Physical laws regarding energy, thermodynamics and the like are an obstacle, but even a partial success in this case is likely to suck for everyone involved. If you want to guarantee large scale destruction with free Green Aesop implications, make your goo specifically designed to clean up oil spills so that it has a built in taste for organic compounds, and is hard to kill. Can cause The End of the World as We Know It — specifically, Type 3a or 4 on Apocalypse How. Compare Blob Monster. For the Real-Time Strategy game about (and playing as!) the grey goo, see Grey Goo.
open/close all folders
Anime & Manga
- The titular creatures in BioMeat.
- Grey goo has completely devoured Mercury by the time of Gunnm (AKA Battle Angel Alita).
- The WORMS in Sky Girls are related to this. Sort of.
- Turn A Gundam features Black Goo in the form of the Moonlight Butterfly (Gekkōchō), which is named because it manifests as giant shimmering energy contrails that emerge from the titular Humongous Mecha's back like wings. The nanomachines only target technology, but do so on an immense scale; the last time the Moonlight Butterfly was used, it sent humanity into a Dark Age that they're still recovering from (when the series begins, technology is roughly on par with the early 1900s).
- In Yoshiyuki Tomino's original novel, the full powered version of the eponymous Gundam can affect the area from Earth to Jupiter with the Moonlight Butterfly - that's over 600 million miles.
- The DG Cells in Mobile Fighter G Gundam are a combination of this and The Virus, though strangely enough they were designed to be beneficial, as their original purpose was breaking down dead or decaying matter and using it to foster new life. The Devil Gundam instead uses them to reanimate dead humans under its control, or infect live humans and Mind Control them.
- The G-Lucifer in Gundam Reconguista In G (a series that takes place after Turn A Gundam) also has a Moonlight Butterfly system.
- The D-Reaper from Digimon Tamers is a very slow form of Grey Goo, breaking down inorganic matter and reconfigure it into its various agents once it emerges in the real world. It's depicted as a mass of red goo in the series because its actually super-heated to extreme temperatures by accelerating its particles beyond the speed of light.
- What happened to Negaduck after being hit by the Tron-Splitter at the end of the Darkwing Duck story "Crisis On Infinite Darkwings".
- Adam Warren's adaptation of the Dirty Pair revealed that the Earth had been destroyed decades earlier in a massive Grey Goo outbreak, the "Nanoclysm", which led to nanotechnology being regulated and virtually outlawed. The villain of the miniseries planned to use a cache of nanotech to take over Heroes "R" Us's Central Computer, and from there, the known universe. Unfortunately, the Central Computer revealed that it was partially based on something the Nanoclysm left humanity as an apology… His later Empowered had a Grey Goo eruption that created Sexbots, for reasons too complicated and silly to explain but which involved someone trying to use alien nanobots with an untranslated interface for perverse purposes.
- The Filth features creatures like this, but portrays them in a very sympathetic light during the stages of their evolution. The more they spread, the more the world is seen from their perspective.
- The Modular Man from Tom Strong is a hi-scale example of this. Each individual module is about the size of your head. Once he gets to Venus, though, he multiplies until he has something closer to the proper Grey Goo appearance.
- Transmetropolitan mentions it as a possible weapon if the commonly-used "makers" are reprogrammed. The standard MO for handling a "grey goo" scenario is to release "blue goo" (disassembler nanites that degrade matter — all matter — to the point where Grey G can't make more nanites out of it, and then destroy the Grey Goo nanites) to contain the grey goo and restrict its damage to a small area. One brief mention is made of someone who lost his legs because he decided to (and succeeded) shut off the grey goo instead of releasing the blue goo.
- One of the early comic issues of MAD had the planet Mars consumed by the Gookum, a jelly-like pink substance which eats anything organic. It breaches The Great Wall built to contain it, and, worse, It Can Think. It stays dormant for 500 years at a time, and the joke/Mandatory Pulp Sci-Fi Twist is that cherry Jello parfait is completely indistinguishable from dormant Gookum. One day... one day the Gookum will quiver, will stir...
- One issue of Fantastic Four claimed that the reason Reed has never tried to market the unstable molecules the team's suits are made out of is that if a careless person gets ahold of the stuff and pokes it the wrong way with an electron microscope, it starts destabilizing all surrounding matter into an ever-expanding blob of goo.
- Iron Man's Technovore is a nanotechnological entity driven to assimilate and integrate foreign technology into itself.
- In Atomic Robo, Biomega (the setting's resident Kaiju) turn out to be a biological form of this. If left unchecked, they will eventually devour the Earth, then the solar system, the galaxy, other galaxies...
- The Day the Earth Stood Still (2008) tries to reboot the Earth with this. It was more a "Grey Cloud" than Goo, but same strategy.
- G.I. Joe: The Rise of Cobra had "Red/Black" weaponized Goo (which is green for the viewer's convenience), which ate any metal it came into contact with. Thankfully, the designers were smart enough to build them with cutoff switches which neutralized them instantly. It also had a limited life span which meant that if its food source was too far away it would die out, depending on how much of a start it got. Eating the Eiffel Tower would give it enough of a start to devour all of Paris, but it would likely not reach another city. Devour a single ship high in the stratosphere and it dies out long before it reaches anything else. It's unlikely that the nanomites were self-replicating at all. A self-replicating nanomachine is, by necessity, much more complex that a simple molecular disassembler. And if you're foresighted enough to build in a kill-switch, the very last thing you'd want to risk is the possibility of generational copying errors disabling that function.
- The Blob (1958): The monster could be either this or The Virus. No one's really ever gotten close enough to examine it without being eaten. All that's known about it is that it's of alien origin. Oh, and it prefers to devour organic life as opposed to inorganic matter.
- The Blob (1988): The remake of the movie had the Blob be the spawn of a secret government germ warfare project. There it acted less like mindless spreading Grey Goo and more like a malicious, semi-intelligent monster.
- "The Lonesome Death Of Jordy Verrill" from Creepshow features the opening phase of a Green Goo scenario, as Jordy and his farm are overgrown by the alien "weeds".
- Ice-nine in Cat's Cradle turns any water it touches into more ice-nine.
- Century Rain by Alastair Reynolds has Earth effectively uninhabitable from the effects of rogue swarms of nanobots. The nanobots were originally created to affect weather patterns, but they were corrupted. New bots were created to fight those, which went rogue, and so on and so forth. The survivors from the disaster, who now reside in orbital habitats, weaponized the Grey Goo and use it as a weapon of mass destruction. Something similar happens in his Revelation Space universe, where The Greenfly terraformers go rogue and will inevitably consume the entire universe.
- One of the best examples is Wil McCarthy's Bloom, a novel set in a future where the last fragments of humanity lives in habitats in the asteroid belt and in jovian orbit, after the entire inner solar system was devoured in a Grey Goo incident. Earth, Venus, and Mars are now large fuzzy balls of nanotech, nanotech solar sails drift aimlessly throughout the system, and occasionally errant strands drift out on the solar winds and try to devour anything they touch in the outer solar system. It's okay, though, because the billions of people devoured in the incident are merely compressed, not gone, and their brain engrams still survive in the bloom, immortal and living in virtual paradises of their own construction; imagine how powerful a computer would be if it was made from an entire solar system?
- Another über-example would be Charles Stross' Accelerando, where pretty much the same events as in Bloom happened deliberately, and for the betterment of mankind.
- The novel How to Mutate and Take Over the World ends with nanites from a dessert factory transforming the world into key lime pie. And this gets spoiled about a third of the way in, in a fictional review of the book.
- In one of the Thursday Next novels, Thursday's time-traveling father tells her of a future wherein the world was overtaken by such a scenario; the world is consumed by pink slime. It turns out to be strawberry pudding.
- Death from the Skies by Phil Plait presents a berserker Von Neumann probe, which is essentially grey goo on a cosmic scale.
- In Prey by Michael Crichton, the main plot is a Grey Goo experiment which has gone rogue and escaped containment. This one's slightly more innocuous in that it's partly biological and relies on E. coli bacteria to produce new nanobots rather than instantly dissolving anything it touches into more goo (it does seem to have some limited ability to "eat" silicon chips from integrated circuits). Of course, this really just means it needs to find a culture medium to grow E. coli in, and there are all these bags of moisture and nutrients wandering around ...
- Neatly inverted in Charles Stross' Saturn's Children—robots think of organic life as "pink goo," reproducing without limit.
- In Scott Westerfeld's book Specials, the main characters break out of a weapons storage facility using nanotechnology-based silver goo (much more flashy and dramatic than plain old gray goo, to paraphrase the author).
- A rather spooky example presented here as a story, which shows us why you should just let the gray goo be...
- And played with in this story on the same site, where the sentient gray goo triggers the nanoapocalypse to save humanity from an impending asteroid collision.
- Charles Pellegrino and George Zebrowski's The Killing Star includes weaponized Grey Goo which is used to pick off one of the few surviving outposts of humanity.
- Greg Bear:
- In The Forge of God, this is done deliberately and systematically by a belligerent alien race, to humanity as well as at least one other race. The sequel, Anvil of Stars, is the story of a handful of the survivors of Earth — specifically, the children — seeking out the race that destroyed Earth, to enact the Law.
- In Greg's Blood Music, the Green Goo is not nanotechnology, but biotechnology, but operates in basically the same fashion. The "noocytes" consume all the biomass in North America, converting it to more noocytes. It turns out that all the living creatures who are assimilated are also recorded and "alive" in a new kind of reality, similar to "Bloom" above.
- The Melding Plague also ended humanity's golden age in Alastair Reynolds' Revelation Space series. Everybody was enjoying the benefits of a highly advanced nanoscience, until humanity encountered a plague that could subvert all but the hardiest nanotechnology. Such subversion has disastrous consequences for the device in question, anything to which it was attached, and potentially anything nearby. This is partly used to justify the somewhat Schizo Tech nature of the setting.
- Played with in The Dervish House by Ian McDonald. The Grey Goo scenario is a common fear in the near-future setting due to a famous scientist's doomsday predictions of a nanotech catastrophe, even though it's generally accepted that he was just fearmongering and was wrong. A character later comments that the Grey Goo scenario has already happened; it's called organic life. It turns out that self-replicating nanotechnology is key to a massive terrorist attack, but not in the traditional sense.
- Deltora Quest has a literal grey goo flood final Xanatos Gambit If I Cant Have You Nobody Can result of the Shadow Lord's plans. It was designed to kill everything on the continent.
- In the Star Wars RPG supplement The Unknown Regions, a Grey Goo named Mnggal-Mnggal is mentioned. It is sentient, and able to infect any form of matter, as well as take control of creatures as 'zombies'. Its origins are unknown, and it's likely biological. Note: If there was a trope for biological Grey Goo Mnggal-Mnggal would fit there.
- In Jack McDevitt's Chindi, an ancient alien satellite that has already mysteriously destroyed one ship is being much more carefully investigated by a second when the ship begins to come apart. It turns out that the satellite uses grey goo to repair/replicate itself, and the ship is being eaten. Several people die, and one, the artist with a big crush on Hutch, is rescued just in the nick of time.
- In John C. Wright's Count to the Eschaton, the Savants used Golden Goo. It destroyed the cities, where it was released first — killing most people there, with only a few stunned to be transferred with their minds intact — and only by savage, fiery attack by the Giants was the earth saved from their "Golden Age."
- In Walter Jon Williams's Aristoi, a form of grey goo (called "mataglap nano") destroyed Earth That Was. As a result, only the eponymous Aristoi are legally allowed to use nanotech freely and they are fanatically paranoid about the possibility that any given form of nanotech could somehow mutate into mataglap.
- In the short story Mar Pacifico by Greg Mellor, nanotech designed to fight the effects of global warming (by letting the oceans absorb more carbon) sweeps over the Earth absorbing most forms of life. When the protagonist is absorbed, she discovers that humanity still exists as a linked Hive Mind inside the nanotech.
- In SA Swann's Terran Confederacy universe, the human colonies on Titan and the outer moons were devoured by a Grey Goo swarm, leading to Nanomachines being made one of the Heretical Technologies. The Confederacy and its successor states continued this policy, enforcing it with things like hundred kilometer asteroids. It's the Only Way to Be Sure!
- Hal Duncan's The Book of All Hours has Magitek nanites charged with the souls of dead gods. It's an ideal medium for carving new identities on people's minds and souls by tattooing their bodies. A large collection also gets loose at the end of the first book, leading to a Grey Goo scenario that gnaws at the very substance of reality. All that's left are pockets of semi-stable time and narrative as spacetime gets even more fractured than it already was.
- The title Extreme Omnivore Blob Monster in the The Clone has some shades of this, although it's green and not grey. Nearly everything it touches, organic and inorganic, it converts directly into more of its own body mass.
- Discussed derisively in Schild's Ladder, which is set in a post-Singularity galactic society: an AI character mentions the conspiracy theory that metaverse-dwelling minds would assimilate planets for computational resources, calling it as preposterous as accusing organic beings of plotting to turn the world into chocolate for infinite desserts.
- A failed pilot for a TV series called Doorways by George R.R. Martin featured a parallel dimension where, yep, nanomachines used to eat up oil spillages went and ate all the oil. This scenario was the result of Executive Meddling — G.R.R.M's original script (and the one found in his "Dreamsongs" retrospective compilation) featured the parallel Earth as a Winter World, but this was apparently too bleak for a first episode.
- The Replicators of Stargate SG-1 are this trope scaled up to Lego size. When they eventually evolved to silver goo, their diet changed from "any kind of metal" to "neutronium only", thus keeping the new model a rarity.
- A minor example of this was the nanite colony Wesley Crusher was running in one episode of Star Trek: The Next Generation. Fortunately, this goo turned sentient and was willing to be moved to a better food source before it disabled the ship.
- The villain Mantrid in the second season of Lexx used Mantrid drones — basically flying arms — to systematically disassemble and convert all matter in the universe into more Mantrid drones. By the end of the season, nearly three-quarters of the universe had been converted, and the remainder would have been finished off within a few days. Kai tricks Mantrid into flying the sum-total of his drones directly to the center of the universe, precipitating a Big Crunch which destroyed that universe but ejected the Lexx and crew into the next one over.
- In the Tales of Tomorrow episode "Red Dust", space explorers who've just visited a once-populated world overrun by Red Goo discover the pink crystalline "dust" has infested their ship, as well.
- In the Stitchers episode "Two Deaths of Jamie B", the eponymous victim was trying to make nanobots to clean up oil spills and accidentally programmed them to recognize the wrong kind of organic molecules, so that they specifically target living things. Fortunately, he figures this out before they are released and shuts the project down. Unfortunately his boss is Stupid Evil enough to want to restart it as a weapons project.
- The old Lights Out radio serial had "Chicken Heart", a biological grey goo that started out as a cell culture from a chicken heart and turned into some kind of mindlessly spreading cancer blob that quickly overwhelmed the research lab, university, and city that it was created in. Even worse, the researcher responsible, escaping with a reporter in a plane, knows exactly how to stop it, but the authorities refuse. Somewhat more famous is Bill Cosby's Jell-O-soaked retelling as he remembers hearing it on the radio as a kid.
- Gray Goo is discussed in GURPS: Ultra-Tech in a section on Von Neumann machines and points out the waste heat of the goo eating a planet is likely a more pressing threat than being eaten by it. On the up side they require extremely high level technology and are expensive to make, on the down side some versions might be able to fly or travel through space.
- Centauri Knights, a far future/Humongous Mecha sourcebook for Big Eyes, Small Mouth, takes place on a dead alien planet colonized by humans. According to the Game Master information in the back, the reason the planet was vacant was because an ancient war resulted in a Grey Goo superweapon accidentally being unleashed upon the planet (the game even explicitly uses the term "Grey Goo" to explain the phenomenon).
- Virus Bombs of Warhammer 40,000 work on a similar principle to the Red or Black Goo scenario noted above. They utilize something called the Life-Eater virus, which consumes everything organic on a planet and leaves behind massive, highly flammable swamps and gas clouds. A follow-up series of incendiary missiles ignites a planet-wide firestorm that scours any remaining life from the surface, leaving nothing behind but a glowing, lifeless rock. The Imperium uses them in dire situations when a problem can only be solved by destroying a planet. For added Nightmare Fuel, note that the Life-Eater is absolutely in the Chaos God Nurgle's wheelhouse. Many of those who have the authority to use these world ending protocols have wisened up, and will prefer to use a Cyclonic torpedo instead.
- Dungeons & Dragons has this in the form of green slime, which converts anything it touches into more green slime. (Except stone, which is immune to it, and wood is more resistant than most. It dissolves metal very fast, however.) Fortunately, it's immobile, so you can avoid it if you just stay away from it.
- In Eclipse Phase, Grey Goo swarms are among the nastier surprises left behind by the TITANs. There are various types ranging from regular roving disassembler swarms covering much of Earth That Was to the rather more...artistic fractal bombs, which restructure matter into interesting fractal patterns as they spread (nobody is entirely sure why. Presumably, their AI creators simply liked the look...). Their presence is basically the setting's primary Godzilla Threshold...if nanoswarms are involved, even the heroic factions will tend to break out the scorched-earth type weaponry, collateral damage be damned.
- Discussed Trope in Shadowrun; Nanotech became very pervasive in 4th edition, and the Grey Goo concept is brought up, only written off as "unlikely to ever come to pass" and "an urban myth" by some of the (legit) top scientific experts in universe. Ultimately Averted as even when nanotech starts to fall prey to hostile A.I., it's shown that it isn't capable of destruction on anywhere near this scale, though it still proves to be very dangerous.
- Tasty Planet is a game based on Grey Goo where a cleaning agent gets bigger and bigger as you guide it through the levels starting on a Petri Dish until it eats the planet, then the solar system, galaxy, universe, space and time! Then it explodes and everything starts over.
- The last "secret" life form class on SimEarth, robots (unlocked by bombing a Nanotech-class city, fittingly enough), are very well-suited for survival. By this, it means that they reproduce rapidly, they can live in any habitat - even the ocean - and thus can spread across the entire map with little effort, competing against organic life can't even be called a competition, and - oh yeah. They're immune to disasters, even ones activated by the player. All organic life on your planet will quickly go extinct when these guys show up.
- The True Final Boss of Super Robot Wars Original Generation, Septuagint, can be seen as this. It may be more of purple crystals, but its directive is clear: exterminate the whole world by consuming anything to come to its path, and it can even make crystal-based duplicates of things it has consumed.
- In the Mass Effect games, you can find a planet called Zaherux, which is covered with seas of silicon. The flavor text mentions that a popular extranet meme says that the oceans are actually a huge swarm of 'disassembler' nanites.
- Biological version in Outpost 2: Divided Destiny. A terraforming microbe runs wildly out of control, breaking down organic matter, among other things, and forcing both colonies on the planet to try to evacuate-one of the rare versions in which the Goo truly is unstoppable, though one colony can delay it briefly, and the omnipresent threat during the campaign.
- In Hostile Waters, the "alien" antagonists have a Disassembler cannon which fires nanites that are programmed to rip apart matter on a subatomic level. This avoids the usual grey goo problem of endless replication, as the nanites just run out of steam, while still producing similar destruction. It fires at a city and reduces it to mush. It's up to you to blow up the cooling radiators before it fires its third salvo and destroys Central, the world capital. Once you do that, the next shot blows it to hell and spreads disassemblers throughout their base.
- In the intro cutscene of the video game Deus Ex: Invisible War, a terrorist employs a "Nanite detonator" in Chicago, destroying the city. And in the first Deus Ex, the Gray Death is revealed to be an artificial plague.
- In Invisible War, there are also "nanite swells" - clouds of nanobots whose origin isn't entirely clear, but which present a serious environmental hazard and are responsible for the poor health of people forced to live outside protected cities. It's never made entirely clear if these are actually self-replicating or just the remains of weapons or experiments used during The End of the World as We Know It.
- In Sid Meier’s Alpha Centauri, one of the Special Projects shows the video of several containers placed on the site of a battle, littered with debris and dead bodies. The containers open, releasing nanites that look like glowing goo. They proceed to consume everything in sight, including the dead, and use the materials to create a brand-new Hover Tank.
- Tiberium in the Command & Conquer universe can be seen a slow-acting example of it. It needs around half a century to engulf a significant portion of the Earth.
- Grey goo missiles called the "Nano Virus" are a high-level planetary siege weapon in Sword of the Stars. It is amusingly classified as a bio-weapon, meaning you have to go through several tiers worth of gene modification to access it. The Nano Virus is harmless to organics, but the planet's industrial output will be heavily damaged and it will wipe out an AI rebellion as if they were living creatures hit by a regular bio weapon. It is the only bio weapon that will affect the Zuul, since their machinery is made of the same metal as everyone else's.
- Parasite Eve features massive amounts of Pink Goo. The Big Bad is actually a Patient Zero infected with intelligent pink goo by accident. Every enemy in the game was created by the pink goo. If you go on to the Chrysler Building in the EX game, the building itself is infected with the pink goo (which is the in-world reasons that mode has random maps) and pink goo is literally everywhere.
- A grey goo like attack is possible in Supreme Commander 2. The Cybran Nation can upgrade their engineers to have weapons, by doing this and building nothing but engineers you will get an ever growing blob of engineers that will automatically shoot every enemy in sight and use the remains to build more engineers. Full instructions here.
- In Smoke's ending in Mortal Kombat: Armageddon, the power of Blaze causes his nanobots to go into overdrive, consuming all of Edenia and replacing it with a sentient mass of grey goo that calls itself Smoke.
- The Vasari from Sins of a Solar Empire, who specialize in Nanotechnology, have ships that are able to throw blobs of destructive nanobots at enemy ships.
- Provides the backstory and setting for Hawken. In the endless Corporate Warfare on the planet Illal, one of the three dominant Mega Corps collapsed, triggering a self-replicating nano virus that converts the environment into a labyrinth of patchwork metal—known as the "Giga Structure" and "Hawken Virus." At the time of the game's launch, the virus covered a third of the planet.
- The Eldritch Abomination Deus from Xenogears is upgraded from a simple biological weapon into a living mass of Grey Goo by the game's Big Bad Krelian through nanomachines.
- The RTS game Grey Goo has you-know-what as one of the factions. Apparently it was originally designed by humans to explore space, but its programming got corrupted somewhere and now it just attempts to consume all before it. Though eventually it is revealed it is attempting to consume all before it for a reason and not just due to programming corruption — it's a desperation move to build up an army against an attacking alien intelligence.
- The Tarr in Slime Rancher are an organic example. They are formed when too many slimes eat too many plorts from other slimes and all they do is drag slimes and meat like the player and chickens and eat them. If they eat a slime they produce a copy of themselves.
- A possible story line from Duskers talks about the gray goo possibly wiping out life in the universe, or just within the Drone pilots area of operation.
- Part of the plot of Mighty No. 9. The Final Boss, Trinity, was accidentally programmed to absorb everything it can, and it does. Which results in it absorbing nearly an entire building, transforming it into the game's cube-like equivalent of nanobots.
- This page of xkcd jokes about how IPv6 is perfect in that the nanobots will only be able to devour about half the planet before they run out of addresses.
- Schlock Mercenary:
- Hostile nanoswarms are so common that there's standard-issue tactics and equipment to stop them; people worried about nanobot infection drink nanotech-fighting chemicals to control them, "nanofilm" is routinely employed to control rogue nanobot swarms, and worst comes to worst, the nanobots will be isolated by ubiquitous AI with gravity-control technology.
Employer of the month: We've all been drinking Nanneze like it was Ovalquik.
Tagon: Careful, that stuff'll kill you.
Employer: What, the Nanneze, or the Ovalquik?
- The comic does point out one of the biggest weaknesses of nanobots: Extreme heat. Even when they have evolved plasma shielding, any reasonably dangerously level of heat will overwhelm any defenses the nanites have and cause their inner workings to warp and fail. If a gravitic-enabled AI isn't around to help, it's common to bust out the plasma weapons on wide spread to handle hostile swarms. For bonus points, most Power Armor in the setting can handle fire without too much difficulty, so you don't even have to worry about your own men. Unarmored Civilians however can at best hope to get off with third degree burns to their entire body. Good thing medical technology has made a few advances...
- Hostile nanoswarms are so common that there's standard-issue tactics and equipment to stop them; people worried about nanobot infection drink nanotech-fighting chemicals to control them, "nanofilm" is routinely employed to control rogue nanobot swarms, and worst comes to worst, the nanobots will be isolated by ubiquitous AI with gravity-control technology.
- Nobody Scores!: When all you have is a jar of nanorobots, everything looks like a problem best solved by the application of nanorobots.
- In the late 20th century of the Chaos Timeline, nukes are scrapped because nanobots made them obsolete. The so-called Braunschleim scenario is the casual armageddon scenario everybody fears. On the eve of World War III, this fear urges a bunch of Playful Hackers to seize control over the military and the rest of the world, in order to prevent the danger of nano annihilation.
- In Orion's Arm, humanity's exodus from Old Earth was caused by the Nanodisaster. Interestingly, this is a case where the grey goo itself was quickly neutralized by blue goo (nanites created specifically to neutralize grey goo). The Great Expulsion was more due to the Global Artificial Intelligence Amalgamation created to protect Earth from human technological disasters by controlling said blue goo deciding to protect Earth from human technological disasters once and for all. The only choices were to live under strict ecological rules, get the hell off of GAIA's world, or face destruction.
- SCP-204 is a downplayed example, as the cloud of nanomachines usually only destroys animals (including living people) to serve as fuel. But SCP-204 is still ranked at the highest threat level possible, probably because from organic matter to anything else is a quick jump.
- In Godzilla: The Series, one of the first Monsters of the Week is a colony of self-replicating petroleum-eating nanomachines that, inevitably, goes out of control and turns into a Zilla-sized shapeshifting blob on a feeding frenzy.
- An episode of the 1980's animated The Incredible Hulk involved a scientist bioengineering a Blob Monster that could eat literally anything except the special glass of its container, and would get bigger the more it ate. Of course the glass breaks and it starts eating Gamma Base. Fortunately, it turns out that the one thing it's allergic to is gamma radiation, which the Hulk constantly emits.
- The Justice League Unlimited episode "Dark Heart" dealt with alien nanomachines that were in the process of taking over Earth this way. Their species appears to be made artificially for a war from fifty-thousand years ago, and is meant to consume every planet they're sent to, spread to some other planets, and repeat until they're all dead.
- The Transformers episode "Kremzeek!" involved a highly specialized electricity eating spark creature, splitting into new copies of itself as it ate more and more current. The "annoying replicating electrical prankster" is a kids' show plot that really gets around. In the old Teenage MutantNinja Turtles cartoon, it's called The Big Zipp Attack, in The Mighty Ducks it's "Zap Attack." Ben 10 has the imagination to not name it after the creature: instead of something like "The Megawhatts Attack," the critters are first encountered in Tourist Trap. (We find they're actually an alien race called Nosedeenians.) It's not as obligatory as the "Fantastic Voyage" Plot, but watch enough cartoons and you'll know it by heart.
- One episode of The Powerpuff Girls features Grey Goo nanobots dropping from a raincloud and destroying Townsville, though the bots thankfully ignored living creatures.
- Code Lyoko
- In the episode "Marabounta", Jeremie tried to create a virus that would destroy XANA's monsters, using Franz's Hopper's journal and basing it off African army ants. At first the huge blob-like monster seemed to work, attacking and devouring XANA's minions. Then something went wrong, and it tried to attack Aelita. Jeremie realized too late that her connection to XANA was causing it to mistake her for one of the monsters, but by then it was out of control and growing larger by the minute, threatening to consume all of Lyoko. (Leading to one of the most chilling scenes of the series to date, Yumi trying to protect Aelita, only to be devirtualized when she was Eaten Alive by the thing.) Fortunately, XANA, who at that point needed Aelita alive to complete his plans, instructed his monsters to help the heroes, and due to the brief alliance, they bought enough time for Jeremie to program an anti-virus that eradicated it.
- An earlier episode "Amnesia", had XANA infecting nanobots from a class as an infestation to cause massive amounts of memory loss.
- In the Gargoyles episode, "Walkabout," an artificially intelligent nanite mass begins a grey goo surge and the only way to stop it is to communicate with it in the Dreamtime. Once that was achieved, the mass was convinced to stop by interesting it in learning about human law and order and it bonded with Dingo's power armor for that purpose.
- Parodied in Futurama episode "Benderama", thanks to an invention of the professor's that can make two half-sized duplicates of an object using consumed matter. Bender integrates the device into himself and starts making half-sized duplicates of himself by eating random objects. Each of the duplicates has the same ability. Eventually the replica-Benders become small enough to manipulate atoms directly and start consuming the planet's mass. Eventually, though, the quintillions of nano-Benders get fed up with doing work for Bender and leave the planet.
- In the My Life as a Teenage Robot episode "Party Machine", an army of tiny multiplying aliens invade Earth, which Jenny and Brad defeat with a vacuum cleaner-like tool created by Dr. Wakeman to defeat them.
- The scenario was first proposed by Eric Drexler. He has since dismissed it as unrealistic as it's much easier to create a bunch of tiny dumb robots that receive their instructions from a central computer (that can be disabled if it malfunctions) than it is to create tiny robots that know and are capable of doing everything they need to make copies. The dumb nanobots should serve any purpose we'd need smart nanobots for, so any grey goo scenario would have to be created maliciously.
- There's also the thought of police nanobots designed to keep the grey goo in check, a concept called "Blue Goo".
- Life itself has spread to every conceivable corner of the Earth (that we have been able to check so far) in the last 4.5 billion years and readily converts non-living matter into living matter through its inexorable reproduction. It is also really, really difficult to truly sterilize anything. This is sometimes referred to as the "green goo" scenario
- Hela cells (an immortal cancer cell line used in biomedical research) act like Grey Goo, in that they're notoriously hard to kill off and often contaminate and convert non-Hela cell lines. Hela is such a problem in many labs that, if the lab wants to use Hela, it cannot use any other cell line in fear of compromising good science.
- A nuclear chain reaction could be considered a subatomic version of Grey Goo, in how it spreads from atom to atom, splitting each one so it ejects neutrons that split other atoms and thus perpetuate the process.
- Prionic brain diseases such as mad cow operate like Grey Goo for the nervous system, as abnormal proteins cause adjacent protein molecules to be reconfigured into more of the same.
- A more harmless, benevolent version of Gray Goo involves theoretical space exploration. It's believed that once we acquire the right technology, we'll be able to create interstellar probes out of nanobots. Once they land on a planet they'll convert as much matter needed into ten more nanobots and fire them out into space.