The (il)logical conclusion of Antiintellectualism. (Not pictured: Human rights.)

"You ever heard of a transorbital lobotomy? They sap the patient with electric shock, then go through the eye with an ice pick, pull out some nerve fibres. Makes the patients much more obedient. Tractable. It's barbaric. Unconscionable."

"Welcome to Bedlam House. Before we get started, I'll plunge this icepick into your eye socket. Mwahaha." One moment you'll see a character, chirpy, energetic, and arguing with the nurses. The next day, they're quiet and compliant, drooling, emotionless — in short, Empty Shells. What took place? A Lobotomy.

Lobotomy is a rare medical operation that cuts into part of a person's brain in order to treat mental illness. Lobotomies and similar drastic brain alterations are still used as last-ditch treatment for intractable epilepsy, but that's about it. In Real Life, there was little evidence that it did anything therapeutic. The most often performed procedure rarely helped; it simply destroyed random brain matter.

This trope includes all instances of messing with human brain and removing brain matter and it refers to any sort of brain-tampering effect that diminishes intellect or willpower. Once seen as a perfectly humane thing to do, now treated in fiction as the standard example of medical science gone horribly wrong. Lobotomy in fiction is almost never presented as an actual therapy, but rather as a threat held over people or a means of rendering an inconvenient subject compliant and unable to threaten the one who performs it. Very rarely it appears as genuine attempt to treat the patient.

Electro-convulsive therapy has a similarly bad reputation in fiction, though less deservedly. ECT is often portrayed as Electric Torture, although nowadays, in democratic countries, it is administered under anesthetic. It is still used, and frequently works, in cases of severe depression which has not been alleviated by milder treatments.

Contrast with Laser-Guided Amnesia which is a relatively mild thing in fictionland you can do to inconvenient witnesses. See also Brainwashed, Brainwashed and Crazy, Death of Personality and Mind Rape.

Mad Scientist or Deadly Doctor are likely to perform it, and Psycho Psychologist is another deadly figure who may suggest this procedure.

Realizing that a character underwent a Lobotomy might very often come off as a Spoiler Trope. Beware!


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    Comic Books 
  • In one comic, Lobo had his brain transplanted into a robocop expy. Once he got back to his body, he repaid the people who used him by returning the favour... using a rusty butter knife.
  • Braniac cuts Aquaman's brain in Justice. Don't worry, he gets better.
    "What is that saying you humans have? Oh yes...'I'm just trying to get inside your head.'"
  • Superman:
    • Justice Lords' version of Superman would "lobotomise" villains as his standard way of solving problems, using x-ray and heat vision for instant effect.
    • Superman pretended to use this method once, when an amoral anti-hero pushed him too far.
    • It happened in the backstory for General Zod's henchman, Non. He was once a brilliant scientist and friend of Superman's father, Jor-El. However, when he tried to help Jor-El to warn the people of Krypton about their impending destruction, the ruling council had him lobotomized to silence him, leaving him a mindless brute.
    • Used by the Communist Superman to control dissidents in Superman: Red Son.
  • Judge Dredd: Happens frequently in the 2000AD/Judge Dread comics.
    • In the Apocalypse War arc, the captive Chief Judge was given brain surgery that removed any desire to resist interrogation.
    • Mean Machine Angel was lobotomized, only it didn't help.
    • In Mega City One, racking up ten misdemeanour convictions gets you a mandatory lobotomy.
    • Dread himself was given brain surgery to remove his sense of guilt over the tragic fate of an innocent young girl.

    Comic Strips 
  • Calvin and Hobbes:
    • When Calvin is making a jack-o'lantern, he plays that he's giving the pumpkin a lobotomy.
    Hobbes: Ugh! No anesthetic even.
    • When Susie tells Calvin she enjoys going to school to learn, Calvin looks thoughtfully at her before declaring: "Your bangs do a good job of covering up the lobotomy scars."
    • After Hobbes cuts Calvin's hair and messes up, he tries to cover it up by tying a cloth around his head. While Hobbes thinks he looks like Lawrence of Arabia, Calvin thinks he looks more like a Lobotomy Patient.
    • When Calvin and Susie are playing doctor and patient, Susie says that her foot hurts. Calvin responds that it's psychosomatic, and she needs a lobotomy,

  • Planet of the Apes (1968): The original movie with Charlton Heston has one of the human crew-members lobotomized by the apes. Well, not really a straight example: he took a bad head injury when they captured him, and the lobotomy was in an attempt to stop fatal internal bleeding. It still turned him into a walking zombie, though.
  • In Sucker Punch, Babydoll is sent to a corrupt asylum and is scheduled to be lobotomized, which is what motivates her to make an escape plan. At the end she gives up her chance at freedom to let another girl escape, and ends up getting lobotomized.
  • In Grave Encounters, the doctor at the Abandoned Hospital was known for unethical practices, especially lobotomies. He eventually gives one to the only surviving main character at the end of the movie.
  • The practice of frontal lobotomy is discussed by the workers in Session 9, in what turns out to be Chekhov's Lecture.
  • Shutter Island: During the course of US Marshall Teddy Daniels' investigation into the titular mental institution, the procedure is mentioned as one method used to "cure" violent inmates that have proven otherwise unable to be helped. After a few Plot Twists and meetings with Andrew Laeddis and Rachael it is held as a threat against Daniels in his attempts to escape the island. Finally, after The Reveal, The whole plot is revealed as an elaborate set-up to give Daniels, who is actually Laeddis committed to the asylum after killing his wife because she murdered their children in her own insanity, once last chance to cure himself. He experiences My God, What Have I Done? and chooses to maintain the fantasy, knowing that it will mean death or worse, and undergo the procedure.
  • In the movie Repo Man, one lunatic character laments on how great he felt after getting a lobotomy himself. Of course, he also talks about how radiation is harmless.
  • The movie From Hell shows the man also known as Jack the Ripper demonstrating how to perform a lobotomy to a group of medical students.
  • Muppets from Space: It nearly happens to Gonzo. The man attempting to perform the lobotomy is a classic Mad Scientist.
  • In Total Recall (1990), Quaid is told by one of his co-workers it is what nearly happened to a friend of his when he went to Rekall. Later in the movie, Quaid is told that he is hallucinating the adventure in his brain and that if he doesn't exit it, he will be lobotomised. It's left ambiguous as to whether the man who told Quaid was lying or whether Quaid was indeed lobotomised. note 
  • The Lobotomist (PBS film) traces the career of Walter Freeman from 'savior' of mentally ill people to being seen as a perpetrator of a brutal mistake.
  • Actress Frances Farmer gets lobotomized in the biopic Frances, although it's generally agreed that this never happened to the real Frances Farmer.
  • A man who managed to escape the Cube in Cube Zero (the prequel movie to Cube) was recaptured by the people running the Cube project and given a lobotomy, and put back in the Cube.
  • In the movie Brain Dead (1990) (not to be confused with Braindead from 1992), a neurosurgeon is hired by a corporation to perform highly unethical brain surgery on an ex-employee. In the end it's suggested that the movie is the fragmented memories of the neurosurgeon himself who has been reduced to a dissected brain kept alive in a lab.
  • At the end of The Shadow, film and novelization, the villain is lobotomized in such a way that all he has lost is his psychic powers.
  • In Clonus, lobotomy is one way to control unruly residents (who are clones for rich adults living elsewhere in the world, made to be a backup supply if they need an organ transplant).
  • In Re-Animator, Dr. Hill is a specialist in this procedure. After he's decapitated and reanimated himself, he uses the technique on reanimated corpses to render them obedient to his commands, not just randomly destructive.
  • In Universal Soldier: Day of Reckoning, Dr. Su attempts performing lobotomy on John to erase his memories. He fails when he breaks free after having yet another vision of his fake family.

  • One Flew Over the Cuckoo's Nest:
    • The patient who was an angry lunatic before undergoes the procedure, and he becomes an empty shell after his lobotomy. His eyes are described as being like burnt-out lightbulbs.
    • After McMurphy attacks Ratched, he is lobotomized and left in a vegetative state. Bromden mercy kills him.
  • John D. McDonald's Travis McGee novel Nightmare in Pink. McGee is falsely committed to a corrupt mental hospital where the villains plan to lobotomize him to eliminate him as a threat.
  • A rather distressing-detailed scene in the first book of Mercedes Lackey's Obsidian Trilogy has a wizard preform a magically-generated version of lobotomy on a young girl, because it's against the law for a woman to use magic.
  • In Hannibal, it is a side effect of cutting open Krendler's head and serving him his own brain to eat.
  • At the end of The Etched City, Raule lobotomizes the head of a crime syndicate.
  • In Sylvia Plath's 1963 novel The Bell Jar, Valerie gets one of these. Valerie is a friend of Esther’s in the private mental hospital. She is friendly and relaxed.
  • From the New World: The queerats perform a botched lobotomy on the Robber Fly queen, and presumably the queens of the colonies that allied with the Robber Flies. Squealer claimed they did it because the queen was suffering from mental illness, as well as because they felt their rights as sentient beings weren't being respected, but mainly to organize a coup. This procedure changes the queerat queens from occasionally violent, tyrannical despots to mindless baby-factories which are treated as livestock. Regardless of rationale, Saki and Satoru are reasonably freaked-out by this revelation.
  • Memoir My Lobotomy by Howard Dully: The author is a troubled youth as a 12-year-old boy in 1960, in and out of trouble at school and home. When his stepmother looks for a solution, Dr. Freeman, one of the popularizers of the technique, suggests a lobotomy, and it occurs. The book discusses how many patients were killed or injured by the technique and implies that the author would have been diagnosed with ADD.
  • There is a book series by Nancy Holder called Possessions about a girls' boardings school haunted by victims of any insane asylum where lobotomies were practised.
  • In Norbert Wiener's short story "The Brain", a gangster costs a doctor his family with his driving (they do not die... not immediately). Some time later, the gangster's mooks summon the doctor to perform urgent surgery on the gangster, who got hit in the head (allegedly in a car crash). During the next robbery, the gangster and all his gang are killed due to a complete lack of planning.
  • His Dark Materials: The General Oblation Board develops a procedure called intercision, which severs a person from their dæmon/soul and has a similar effect on the person as being lobotomized.
  • Doc Savage: In early stories, criminals captured by Doc received "a delicate brain operation" to cure their criminal tendencies. The criminals returned to society fully productive and unaware of their criminal past.
  • The novel Geek Love by Katherine Dunn features a pair of Conjoined Twins, Iphy and Elly. Eventually their brother Arty has Elly lobotomized.

    Live-Action TV 
  • The Prisoner:
    • Used for mind games. Number 6 is made to believe he's been lobotomized in the episode "A Change of Mind".
    • In "Dance of the Dead", Number 6's former colleague Dutton ends up lobotomized for real.
  • In The X-Files episode "Unruhe", Jerry Schmauz was a serial lobotomist. He believed he was helping his victims who were troubled women. He claimed he saw their inner demons — and indeed, they were captured by photography.
  • Barney Miller:
    • There was a recurring character who had had a lobotomy.
    • "The Desk" was an episode involving a lobotomized criminal and an Amish mugging victim.
    • Arnold Ripner threatens to sue a lobotomist free of charge should he try to operate again on a patient who was rendered mentally incompetent by his amygdalectomy.
  • River in Firefly had parts of her brain removed, removing her ability to suppress her emotions. She was a genius child and abused by the controlling Alliance, who experimented on children like her. The programme was a bit shady and it was not clear why they did it. In Serenity, it was revealed they wanted to turn them into Super Soldiers.
  • An episode of Law & Order: Criminal Intent had the villain drilling a hole in random women's heads and pouring in boiling water. Most of them die. Interestingly while most of the team consider him a horrific monster, he's shown as more pathetic than scary or evil. Goren tries very hard to get him life in prison rather than the death penalty. It doesn't end well.
  • President Cyclops, in the TV version of Whoops Apocalypse, declares: "If anyone tries to lobotomize me, they'll get a piece of my mind." This doesn't prevent the Soviets planting a lie detector in his brain.
  • Fringe: Walter Bishop tries to self-lobotomize because he believes his visions of Peter mean that he's losing his mind.
  • Rosemary Kennedy was a sad case of Truth in Television. It was used in The Kennedys miniseries, in which Joe Sr. has a stroke later, which is seen by his wife as God's revenge for what Joe did to their daughter.
  • Dr Arden from American Horror Story: Asylum gives a lobotomy to a patient who recognized him as a Nazi war criminal.
  • Monday Mornings has a rare positive portrayal from a 2013 Medical Drama, but treated extremely seriously. Dr. Ridgeway, a brilliant neurosurgeon, sees no other way than a radical treatment for one of her patients — removing several brain cells. It's risky and her colleagues point out both to Ridgeway and the patient's family that it's still brain matter removal, albeit delicate and precise. They actually use the word "lobotomy", and it gets mentioned than one patient who underwent similar procedure in Europe turned into a violent criminal.
  • Occurs in the infamously So Bad, It's Good Star Trek: The Original Series episode "Spock's Brain", in which aliens, to put it simply, steal Spock's brain, and the episode revolves around the Enterprise crew getting it back and reattaching it.
  • The Space: Above and Beyond episode "Stay with the Dead", Nathan is threatened with a Sci-Fi version of a lobotomy (stated to be electroshock therapy but depicted as some form of neurosurgery) because he insists his squadron mates are alive when everyone else has written them off. They are, and he manages to convince his CO before doctors carry out the procedure.
  • Sylar tampered with brains of many people in Heroes. Charlie Andrews, sort of Bridget Bailey, Brian Davies, Sue Landers, Joe Macon, Dale Smither, Ted Spague, Tom Miller, Jesse Murphy, Candice Willmer, Zane Taylor, James Walker, Trevor Zaitlan, Bob Bishop, Isaac Mendez, possibly David, and a random man and woman that work at The Company. Plus, with every person he kills, he gains a power. What's really evil is that he doesn't actually need to kill his victims to take their power. He just likes doing it. Justified as he didn't realise he could take it without killing for almost all of his victims. By the end, he has at least sixteen powers taken from the dead.
  • This is standard procedure for taming an Ood on Doctor Who. It's nowhere near as messy as a real lobotomy, though. The procedure removes a part of the brain that's outside the body, meaning all the surgeon does is cut the cord that attaches the external brain to the internal brain. Since the external brain contains an Ood's memory, emotions, and individuality, removing it turns the Ood into a docile, mindless slave. To make the Ood even more docile, the slavers also created a force field to cut off the Ood's mental access to the gigantic disembodied brain that would otherwise link them together in a psychic network.
  • In Murdoch Mysteries, episode "Murdoch of the Living Dead", a psychiatrist Dr. Luther Bates is revealed to have been performing lobotomies through nose. He was experimenting with criminals and tampering with their brain. He believed he would help society to deal with violence and crime, but he showed to public only people who turned docile. Some of his victims ended up Brainwashed and Crazy and extremely violent.
  • Mad Men: Pete Campbell's brief flame, Beth, was subjected to several lobotomies by her philandering asshole husband due to her habit of getting really depressed and running to the first guy that gave her positive attention. Pete comes in to see her after the procedure and though she welcomes him, she doesn't remember a thing about him.

  • Song "I'd Rather Have a Bottle in front of Me (than a Frontal Lobotomy)", referred to as a Dr Demento classic. It's all in the title, but to recap: would you rather solve your problems with alcohol, Drowning Your Sorrows, or would you choose frontal lobotomy?
  • The song "I'd Rather Have a Bottle in Front of Me than Have to Have a Frontal Lobotomy" is referenced in Tom "T-Bone" Stankus' song, "Existential Blues".
  • Discussed in the "Weird Al" Yankovic song "I Can't Watch This".
    HBO and Playboy, Showtime and MTV
    I might like them more after my lobotomy
  • Oingo Boingo's song "Perfect System" mentions the operation and tampering with one's brain.
    "I had an operation. With no adverse reaction. They tampered with my brain some. It helped me see the reason. For living in the system."
  • Emilie Autumn's song "Miss Lucy Had Some Leeches"
    ''Before the night is over
    Before you go to bed
    They'll take a hammer and a nail and jam it in your
    Headstones in the courtyard..."
  • The Ramones have a song called "Teenage Lobotomy" from Rocket To Russia, which is actually about abusing the insecticide DDT as a drug. You get the brain damage without the docility, it seems.
  • Purgatory (later renamed Iced Earth) had a song called "Lobotomy" on their first demo Burning Oasis, as well as on live bootlegs. The demo has yet to be shared online by anyone, unfortunately.

    Role-Playing Games 
  • Wallace Bishop of Dino Attack RPG is an unusual example, considering that he actually performed a lobotomy on himself after escaping Napoleon XIV Mental Institution, rather than letting one of the doctors in the institution perform the lobotomy on him. Being a former scientist, he knew exactly how to do the procedure. His goal was to remove the areas of his brain containing the memories of his family, which were making it much harder for him to cope with being institutionalized. He succeeded to such a degree that another scientist, Frank Einstein, was even able to extract the memories from the removed pieces of brain, but in doing so he left himself little more than a shadow of a man.

    Tabletop Games 
  • Players of Magic: The Gathering can use Lobotomy spell as sorcery. Link to a Lobotomy card.
  • Warhammer40000: The most prominent example of this trope are servitors, lobotomised cyborg slaves. World Eaters (an entire army of Berserkers) have lobotomies so as to ensure they no longer feel fear. Unfortunately, those with the skill to perform this operation are increasingly rare, so a great many of them fail. Then again, given what most Chaos units, especially Khornate, ESPECIALLY World Eaters are like...
  • Paranoia supplement Acute Paranoia, section "Sanity Tests". When a Troubleshooter fails a Sanity Test ordered by The Computer, the game master rolls on the Handy-Dandy Sanity Tests Results Table. One of the entries in the table is "Corrective Surgery". Blue-level officers from HPD & Mind Control take the unlucky clone away and remove parts of his brain. When he returns he will have a large bandage on his head, will have lost all of his skills and have had most of his attributes halved. This being Paranoia, the player may decide to try to get that character killed quickly and bring in the clone replacement. However, since the game rules actively encourage the GM to cheat to reward players who are being entertaining and a character who is trying to get killed can be pretty darn entertaining, that character may be around for a long, long time (at least by Paranoia standards).
  • New World of Darkness sourcebook Asylum is based around psychiatric care in the setting, with a sample hospital, Bishopsgate, that has operated since the 1800s. This, of course, means that it existed when lobotomies were in vogue, and so they're discussed. One head of staff in particular, Dr. Jeremiah Moorcock, was quite fond of performing them. He was removed from the hospital after an unknown assailant gave him a transorbital lobotomy.


    Video Games 
  • BioShock Infinite:
    • If Slate's life is spared he will be found later on in the game, the apparent victim of a lobotomy or some similar "procedure" by Comstock's forces that has left him an Empty Shell to keep him from continuing to spread dissent and treasonous information about Comstock,that happens to be both true and false From a Certain Point of View. Because The Dev Team Thinks of Everything you can opt to put him out of his misery and Elizabeth will comment on it, saying, "I guess that's what he wanted."
    • In "Burial at Sea", Atlas nearly gives Elizabeth one while torturing her for information. He even sticks the needle in and taps it a few times with a hammer. And you get to experience it all in first person! Elizabeth simply laughs it off though, saying that he'll be doing her a favor, by making her no longer care about all she's been through. He then threatens to do it to the Little Sister Elizabeth had been trying to save the whole time. She quickly gives in.
  • There's a doctor in Psychonauts who removes entire brains. His name? Doctor Loboto. He's (actually a dentist) and removes brains whole, so they can be used to pilot psychic tanks. They're removed through an extreme form of Pepper Sneeze, and are just as easily replaced.
  • In American Mc Gees Alice, there are nightmarish children wandering around some levels. Many of them have their skulls cut open, with brains exposed.
  • In Mystery Case Files: Escape From Ravenhearst, the Master Detective must perform a simulated lobotomy on an animatronic "mental patient" so she can beat him in a card game.
  • Not physical lobotomy but in Dragon Age mages can be made Tranquil; they are cut off from the Spirit World Fade and therefore lose any ability to become a tasty demon-snack but also lose all emotions and willpower. Public use of the Rite of Tranquility was meant to be as an alternative to killing a mage who cannot or will not control their powers, tantamount to execution. However, as centuries went by, it ended up being used as Disproportionate Retribution for petty offenses, and some things that weren't even offenses but were trumped up to be. The operation is believed to be irreversible, but in Asunder, a Tranquil mage under the Divine's orders successfully researches a "cure" (which consists of tricking a demon or spirit into "touching" the Tranquil's mind from the Fade)—and is utterly overwhelmed by his newfound emotions, turning into a Nervous Wreck overnight. Something similar happens in Dragon Age II when Anders, an Abomination with the Spirit of Justice/Vengeance inside him, meets an old friend named Karl who was recently made Tranquil. The sight of his now Tranquil friend infuriates Anders so much that Justice temporarily manifests itself. The presence of the spirit temporarily restores Karl's emotions. Karl begs Anders to kill him since he doesn't want to go back to his dreary emotionless state.
  • Lobotomites are common enemies in the Fallout: New Vegas add-on, Old World Blues, who have had their brains removed and replaced with imperfect tesla coils that are meant to receive the signal from their disembodied brains but don't quite work. This fate befalls the Player Character as well, but the process is perfected on them so they stay sane. You can even opt to leave your brain, heart and spine behind and use cybernetic implants instead.
  • Implied by MODOK in Marvel vs. Capcom 3:
    One of his winquotes: Never again will I forget to lobotomize one of my clones!
  • Five Nights at Freddy's:
    • The infamous Bite of 87 from the first game. During a birthday party, one of the animatronics malfunctioned and took a chunk out of one of the people at the restaurant. Other than that, the details of it are unclear.
      Phone Guy: I-It's amazing that the human body can live without the frontal lobe, you know?
    • The example from the first installment is explained in Five Nights at Freddy's 4. The kid you play as got their head stuffed into the mouth of the Fredbear animatronic by their Big Brother Bully. It was meant to be a prank, but then Fredbear accidentally bit down...

    Visual Novels 
  • Dr. Irie, from Higurashi: When They Cry studies practices of this subject. Portrayed somewhat sympathetically, as he really is helping people. The people who pay him are much more shady, though.
  • Not actually carried out, but in Hatoful Boyfriend Holiday Star, when Hiyoko sees Shuu acting rather out of character she asks if he's gone and had that lobotomy.

  • Questionable Content: On Faye's first visit to her therapist, the therapist jokingly suggests lobotomy.

    Web Original 
  • Lobotomies scored number 6 in Cracked article "The 10 Most Insane Medical Practices in History". Lobotomies were a popular medical technique for the first half of the 20th century and miraculous "cure" for nearly any mental issue from serious conditions like schizophrenia to mild anxieties or teenage angst. Read it here.
  • Mephisto the Magician references a Doc Savage expy in the Whateley Universe whose "delicate medical surgery" turns out to be a pre-frontal lobotomy, reducing brilliant criminal minds to mental children unable to feed themselves. Mephisto is less than amused.
  • In the Das Sporking recap of Fifty Shades of Grey, the sporkers speculate that Leila may have had a lobotomy, owing to the stunted and lethargic way she behaves.
  • In Das Mervin's readthrough of the Twilight Illustrated Guide, she notes that it would have made more sense to have that Alice got a lobotomy during her involuntary stay at an insane asylum. (She withdrew that suggestion after the listeners pointed out that the time period wasn't when lobotomies were popular as medical treatment.)

    Web Video 
  • In Mortal Kombat Legacy, the doctors at the asylum Raiden lands in attempt performing lobotomy on him, but being a god, he recovers from it.

    Western Animation 
  • The Simpsons: In one Halloween episode, Ned Flanders is global overlord and deals with any rebels by having part of their brain removed. Lobotomized Moe shows Homer "you get to keep the little piece they cut out", and lobotomized Marge just tells Homer that "it's bliisss...".
  • Justice League brings up lobotomy procedures in "A Better World", when Justice Lord Superman manages to lobotomize Doomsday using only his heat vision. When the others decide to check out a mental hospital in the Justice Lords universe, it's revealed that he has done it to many other villains like The Joker, Poison Ivy and the Mr. Scarface. It's how we know he's not a good guy.
    • In the movie Superman vs. the Elite, Superman uses a combination of his x-ray, microscopic and heat vision powers to depower Manchester Black by cutting out the part of his brain that controls his powers. It's implied not to be permanent though, and Black's personality seems unchanged.
    Superman: "Heat vision. Focused through your pupil like a scalpel. Instant lobotomy."
  • On an episode of Tiny Toon Adventures, Elmyra heavily hinted to Montana Max that she wanted him to take her to an upcoming dance. Monty responded that he'd rather have a lobotomy.
  • The Godzilla Power Hour has Godzilla subduing a monster known as the "Gravity Goliath" in this manner. Followed by Godzilla throwing him all the back to the moon, from the bottom of the ocean!

    Real Life 
  • Rosemary Kennedy, sister of U.S. President John F. Kennedy, was subjected to lobotomy at the age of 23 in 1941. This has been used as the basis for Conspiracy Theories.
  • Tennessee Williams' sister Rose is a famous real life case. It went badly, obviously upset Williams very deeply, and it influenced a lot of his writing. The Glass Menagerie is entirely based on the incident and the characters on his family.
  • Jeffrey Dahmer, according to his confessions, attempted to give these to some of his victims while they were still alive, drilling holes in their skulls and pouring in drain cleaner in attempts to create zombies. Thankfully, this more often killed the unfortunate.