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Anime & Manga
- Miranda in D.Gray-Man.
- Jyou Kido from Digimon Adventure, although he mellowed out in Digimon Adventure 02, as he matured.
- Crona from Soul Eater, thanks to being raised to become a new Kishin by Medusa. S/he's even quite jittery when s/he's Axe Crazy.
- Neon Genesis Evangelion: Poor Shinji Ikari, in the first few episodes. It comes in very handy when he's shanghaied into being a mecha pilot. He spends his first few battles freaking out. While he does get much better after the Futagoyama incident as far as battles go, he never quite stops acting like this in his everyday life... and then, of course, any progress he made is undone as everything goes straight to hell...
- Extreme Doormat Bertolt Hoover, from Attack on Titan. He normally manages to keep things under wrap as a Cowardly Lion, restraining it to constant nervous sweating and uncomfortable expressions. But once his composure breaks, he's reduced to Tears of Fear and shrieking in panic. In those moments, it's easy to forget he graduated 3rd in his military class and is the Colossal Titan. How much of this is his natural personality, and how much of it is connected to his Dark and Troubled Past is unclear.
- Aya of Tantei Team KZ Jiken Note has anxiety as her official main attribute. She simply can't handle pressure very well, and in the first few episodes she actually attempted to run away from problems she couldn't deal with. Even in the latter half of the anime she nearly has Quivering Eyes Once an Episode. Strangely, this trope also provides for this series' educational value, as she tries to resolves her "uncertainty of the book"—which are supposed to be the kind observed in tween girls, its intended demograpic.
- In Dragon Ball Abridged, this happens to Krillin. He cannot shut up when he's scared.
- In A Fanciful Dream Bella experiences this. Granted, she thought she was being stalked.
- In Graduate Meeting Of Mutual Killing, Hoshio Saitou really doesn't take well the perspective of being left in a shelter to starve to death. He even considers barricading himself in his bedroom, out of panic.
- In The Witch of the Everfree, Sunset has a series of panic attacks in the immediate aftermath of her removal as Celestia's student, and thereafter whenever she comes too close to encountering Celestia again.
- : Poor Nolan.
Films — Animation
- Rex in Toy Story is very easy to set off, from either external or internal factors.
- Panic in Hercules. The series also introduced Neurosis, whom even Panic considers a mess.
- The second princess in Son of the White Horse is one. She did get married to a dragon who seems to represent the horrors of industrial warfare.
- Max in Mary and Max is one generally, with panic attacks striking whenever his life is "disrupted" — say, by a letter from a curious 8-year-old girl.
- Fear from Inside Out always looks on the verge of a panic attack. Word of God describes him as acting as if he fears losing his job... except that he is his job.
Films — Live-Action
- Woody Allen is famous for playing this kind of character.
- Many, many of the lead roles from French comic actor Louis de Funès are this, a good part of his humor consisting on watching how his protagonists are cracking up under pressure. Although De Funès had to tone it down after his heart attack in 1974.
- Ken the stutterer in A Fish Called Wanda.
- In the Star Wars Universe, Nute Gunray (the Trade Federation Viceroy) nearly embodies this trope. Although beings from his species, Neimodians, are usually pessimistics and prone to great stress by nature, Gunray's overly-nervous personality is well beyond even Neimoidian standards.
- Leo Bloom in all adaptations of The Producers.
- Felix in the film version of The Odd Couple.
- Mr. Salt in Willy Wonka and the Chocolate Factory, after being put upon by his notoriously demanding daughter. And his sanity is not at all helped by what he witnesses in the Wonka factory...
- In Pixels, Q*Bert is terrified of everything, from Matty's brutal computer game through the invasion of Earth up to Ludlow's broken heart.
- In Dragon Bones, Oreg constantly watches Ward, and carefully steps away if Ward shows signs of being angry. Justified in that Oreg has been a slave to all of Ward's ancestors (he's the "child" in the Powered by a Forsaken Child castle of the family) and some of them were ... rather nasty.
- Nettie in Needful Things is always tense and jumpy due to the abuse she suffered at the hands of her husband. Keeton also gradually becomes this as paranoia sets in.
- The Bursar from the Discworld books. He starts off fine in Eric and becomes only slightly twitchy in Moving Pictures. However the events of that book, and the following one Reaper Man leave him a paranoid, twitching, nervous mess, who has to be medicated into hallucinating he is sane (attempts to cure of his nervous state proved impossible).
- In The Dresden Files, Molly Carpenter becomes this in Ghost Story, following Harry's apparent death in the previous book and her own attempt to fill in his shoes as the magic defender of Chicago.
- Piglet, from Winnie-the-Pooh, is a classic example: meek, timid, stuttering, always fretting over something, and in the Disney version is usually seen visibly trembling.
- The White Rabbit, in almost all adaptations of Alice's Adventures in Wonderland, is a Nervous Wreck due to being "late for a very important date," even going so far as twitching a lot.
- Lori reacts to motherhood this way in Aunt Dimity Digs In. In an exaggerated bid to childproof the cottage, she fastens the kitchen cabinet doors so securely that no one can open them, padlocks the medicine cabinet and misplaces the key, and covers the edges of the coffee and end tables with miles of cotton batting. Ultimately, Bill finds her trying to wrestle their mattress out of its frame and onto the floor so the boys cannot crawl under it, although their little knees have yet to touch the carpet. Though she does calm down with time (and the services of a couple of nannies), Lori is still apt to react badly to the idea that her sons could get hurt, and the start of their schooling at Morningside in nearby Upper Deeping sets off another crisis in Aunt Dimity: Vampire Hunter.
- Shrewtooth from Warrior Cats...until he Took a Level in Badass.
- Matt in Peter Pays Tribute panics about things like giving an oral presentation to the class.
- It's not uncommon for characters in the Cthulhu Mythos to become this, usually the result of surviving an indescribable horror. Danforth in At the Mountains of Madness would be a good example.
- Pharamond in Dragon Age: Asunder as a result of curing his Tranquil condition — i.e. having been severed from his emotions for years if not decades, which all come back to him at the same time.
- Nora, from Hush, Hush seems to constantly fret about things. Granted she does have things worth worrying about, but she also seems hung up on the idea that Patch will leave her for better women (despite him repeatedly proving he won't), that something's going to go wrong with whatever she's doing, that Marcie Miller will do something horrible to her, etc. One notable instance is when she's serving Marcie and several other of her classmates at a restaurant. They demand that she sing "Happy Birthday" to them without offering any proof that it's actually her birthday... and this causes Nora to go to pieces and think that refusing will be grounds to get her fired on the first day of work.
- Doug ("Nervous Guy") Murphy from Scrubs, nervous about... everything.
- These show up a LOT in Canada's Worst Driver. They're as scary as road ragers and ditzes.
- Rebecca from Cheers.
- Miles from Murphy Brown.
- Lydia from Breaking Bad is a business executive who's secretly running a drug empire despite the fact that she's high-strung to the point of being completely nuts.
- The Mr. Potato Head Show: Happy Whip, a can of whipped cream with Mr. Potato Head arms attached, comes across this way. Whenever he gets emotional (typically afraid, though pride can have this effect as well), he sprays whipped cream everywhere. The main purpose of his appearances is for him to panic and trigger this.
- Hysterium in A Funny Thing Happened on the Way to the Forum. Even the song "I'm Calm" reflected his status as a near-basket case.
- Harpagon from The Miser, who's almost perpetually high-strung and paranoid about his money.
- Malvolio in Twelfth Night is reduced to this by the end of the play thanks to the inhumanly cruel practical joke the other characters played on him. Granted, Malvolio personifies the Asshole Victim trope, but even the characters acknowledge they may have gone too far at the end.
- In The Sims 3, any Sim with the Neurotic trait is this.
- Every single Elsen in OFF is one of these, to the point taking them two inches out of their comfort zone will trigger some nasty transformations and get them to assault you.
- The Matrix: Path of Neo has a security guard who panics and becomes a, brief, nervous wreck when he sees Neo again, because "I killed you ! I killed you !" He remembers Smith killing Neo, because Smith body surfed him to do it.
- The Justice Minister in Ghost Trick is always seen as an absolute neurotic mess. It's not just a character trait - the source of his immense stress is quite recent, and once you address it, he immediately becomes noticeably calmer. For the record, he was manipulated by a ghost into signing an innocent man's death warrant, and he told no one about this because he thought no one would believe him, which his wife disagreed with and so left him.
- Bob Kerman, one of the main characters of Kerbal Space Program, is usually portrayed as this. Hanging out with Jeb would do that to a guy.
- Hanako of Katawa Shoujo has severe anxiety issues and regularly has panic attacks, and her teacher knows to simply let her run out of class if she needs to.
- Touko Fukawa in Danganronpa and Kazuichi Souda in Super Danganronpa 2. Both are later revealed to have severe bullying issues, abusive parents and mass-murdering levels of misanthropy.
- Flaky from Happy Tree Friends. Taken Up to Eleven in "Without a Hitch" where she got so scared of Flippy killing her, she stabbed him in the eye.
- Corn (Quetzalcoatl) from "No Evil". He's a perpetually nervous wreck who has trouble interacting with everyone else, and is easily spooked. Kitty is the only one who doesn't spook him.
- Dies-Horribly in Goblins: Life Through Their Eyes is always on edge. This is justified because most goblins in his clan are named due to prophecy.
- Jack Delitt from Newheimburg has this issue in spades.
- Dr. Riley Zinc from A Loonatic's Tale.
- Cameron from Zoophobia is providing the page picture. She lives in a land of talking animals and other mythical creatures, which wouldn't be a problem if she didn't have diagnosed zoophobia. Her student Jack isn't much better, since he was literally Born Unlucky on account of his uncle.
- Tirzah from Inhuman Relations does not handle adversity well. Or most anything else, for that matter.
- Camel in Agents of the Realm because of something that happened between chapter 2.5 and 4.5. She's so freaking out she at first mistakes Folami's marriage proposal for an attempt to kick her out of Agents.
- Mannie Sue in Druid City. Generally anxious about any prevalent subject in her life, including social interaction, relationships, dealing with family grief and sexual dysfunction.
- Max from Guardian Ghost , who was already an anxious mess before the series started, and now has to deal with sleep deprivation and stress on top of it.
- Siv Västerström from Stand Still, Stay Silent usually gives the distinct impression she's barely holding back the urge to either cry or tear her hair out. Or, sigh meaningfully in frustration.
- Edward Borman in The Mercury Men. Justified, given the situation he's in.
- The Nostalgia Critic is very prone to panic and stressing out over nothing.
- Dino Attack RPG
- Kate Bishop. The fact that she was an 18-year-old stuck in the middle of a war certainly doesn't help.
- Sam Race also becomes a Nervous Wreck when he starts showing early signs of PTSD.
- This Not Always Right post has a woman who fits the description. Her first response to a woman handing her a balloon is to assume she's trying to kill her baby, that the balloon's going to strangle the baby, and tell the manager on her.
- Tweek from South Park.
- The Earl of Lemongrab from Adventure Time. Whether his character and situation are hilarious, or terribly depressing, is debatable.
- In the episode "The Truth Hurts" from The Replacements, the head of the school newspaper who is replaced is a Nervous Wreck who is constantly jittery and gets extremely nervous about the idea of anything being published in the school newspaper that would make things like fruit on the bottom yogurt as opposed to being like plain yogurt, as he likes it.
- Shaggy and Scooby-Doo are usually this.
- My Little Pony: Friendship Is Magic
- Fluttershy, frequently.
- Rainbow Dash normally presents the exact opposite of this. However, in a few cases it's shown that her cocky façade is just that, and when she is no longer able to put up that façade she collapses into a ball of nerves.
- Twilight Sparkle in "Lesson Zero" and "It's About Time".
- Rarity in "Suited for Success" and the Bad Future of "For Whom the Sweetie Belle Toils".
- Jitters A. Dog from Raw Toonage and Bonkers.
- Mr. Nervous from The Mr. Men Show. He frequently lapses into daydreams, sort of blown-out-of-proportion scenarios involving whatever is going on around him at the time. Whether it be a short two-minute ride outside a store or a spider crawling out of his musical instrument. He will then usually flee for his life, screaming and shouting "Oh no no no!" or "This is the end!"
- Skywarp of Transformers Animated exaggerates this. Here, the Seekers are clones of Starscream, each with one aspect of his personality, and Skywarp has his Dirty Cowardice. Thus, the only emotional and mental state he can process is utter fear. No wonder fans see him as The Woobie.
- Munchy Beaver from PB&J Otter. Oh man, Munchy Beaver. In one episode, he's just getting over getting the measles. Peanut, Baby Butter and Jelly find a frog that looks like it has measles, decide to call it Measles and try to give it to him, but he incorrectly thinks that they want to give him the measles. In another episode, when two of his friends are arguing, he declares out loud, "I hate conflict." When he gets very nervous or worried, he tends to eat large amounts of wood.
Munchy: I'm so nervous. I'm so nervous. I have to go munch some wood.
- PJ on Goof Troop. He's very uptight, panicky, pessimistic, fearful, and will often be shown trembling or freezing with anxiety. Considering that his father thinks the proper way to raise him is to insult and belittle him and to dominate him through intimidation and power, this is understandable. He gets significantly better by the end of the second movie.
- Hey Arnold!: What Olga Pataki actually is. Underneath her "perfect girl" façade there's a Fragile Flower who has next to no self-worth and is severely stifled under her parents's super-high expectations of her, and who breaks down in tears at the mere thought of failing at something.
- The animated version of Dilbert's Loud Howard, borrowing a trait from Nervous Ted to make him at least a tad more rounded.
- Mr. Deetz on Beetlejuice, due to some flanderization from the movie.
Howard: Dogs make me nervous. Crowds make me nervous. Being nervous makes me nervous!
- Wirt from Over the Garden Wall. He frequently hints at a Dark and Troubled Past, which turns out to consist of typical high school social anxiety.
- Anxiety disorders:
- Generalized anxiety disorder and its various sub types/variations.
- Some people with PTSD are this to some measure. Because of their trauma, they are constantly "on guard" and wary of something bad happening to them. Additionally, they may be easily startled and have a Hair-Trigger Temper.
- Most PTSD aren't like this all the time, which is why it's so jarring to observers when an external stimulus causes the sufferer to re-experience the trauma. Lack of understanding of this condition is why Vietnam veterans had such trouble reintegrating into civilian life — even their own families feared the unpredictable and extreme reactions. Due to combat training, veterans' defense mechanisms under this duress can be more dangerous than civilians'.
- Abused children have the same issues/responses as veterans.