In the last decade of the 21st century, humanity faced two of its greatest challenges. The first was the transformation from a single, evolved species to a multitude of artificial races. The second was the settlement of the vast reaches of the solar system. Away from the prying eyes of Earth, space-going transnationals developed technologies that governments feared to investigate but could not ignore, while bizarre posthuman cultures bloomed like exotic flowers. It was a time of wealth and adventure, of transformation and terror. It was the age of Transhuman Space.
from the Introduction to Transhuman Space.
Transhuman Space is a HardScience Fictionrole-playing game setting for GURPS, published by Steve Jackson Games. It features a lot of advanced bitech, "wet" (biologically-based) nanotech, the colonisation of the Solar System (including the terraforming of Mars), human personalities uploaded to computers, advanced artificial intelligence, and a politically multi-polar world.
This RPG provides examples of:
Animal Wrongs Group: Many Preservationist organizations such as the anti-gengineering terrorist group Blue Shadow and anti-terraforming Europa Defense Front.
"Necromorph bioshells" are brain-dead but otherwise functional or repairable corpses (sometimes deliberately created by killing unfortunate victims in a controlled manner) with the brain replaced by a computer, usually then operated by a compliant AI. The trope is usually averted in the sense that the AI is usually as reliable as any in the setting, giving the "zombie" no particular reason to misbehave — unless it's programmed malevolently, perhaps to use the necromorph as a terror weapon.
Certainly, necromorphs, and indeed most human-looking AI-controlled bioshells, are regarded with suspicion in parts of the setting, being more or less regarded as horrific zombies.
The one exception, in some places, is a bioshell body controlled by the digital ghost of the formerly-organic-living person on whom it was based. Of course, if the ghost proves defective, you may have something of a scientifically-created zombie on your hands.
Balkanize Me: Many "Free cities", and Canada has become a patchwork of countries, some of which are EU members. The US hasn't splintered, but many states have; there are now 60, some of which are free cities within the union. (Most of Washington, conversely, is now part of Maryland; the District of Columbia barely extends beyond the White House.)
Brain Uploading: Two kinds. "Ghosts" where the brain is destroyed in the process, and "Shadows", where the brain survives but the AI simulation is an unreliable model at best.
Cat Girl: Felicia-model bodyguard bioroid (sort of an organic robot built out of flesh and nanotech systems, as opposed to a grown organism with its own genome)
Though they don't necessarily have to be girls; catboys are an acceptable option as well.
Author David Pulver seems to put catgirls into every GURPS setting he writes for. His excuse is that there's a large subset of GURPS players who always want to be a catgirl, regardless of setting.
China Takes Over the World: It's the main military power, with the EU as generally the most advanced technological power. America is a close second for both. China's most frequent and direct antagonist on Earth, though, is the "Transpacific Socialist Alliance". (It gets complicated there.) Also, China has taken over half of Mars.
Cloning Body Parts: Cybernetics are considered obsolete. Nearly everyone waits a couple of weeks for a cloned body part instead of just printing off a prosthesis.
Death Is Cheap: Infomorphs get the "Extra Life" trait to represent backups, and even flesh and blood humans have a chance of surviving things that would kill them in most settings — albeit possibly only as software.
Five-Man Band: The line of Personnel Files supplements, providing ready-made PC groups, include a number some that fit this trope fairly well:
Personnel Files 2: Leader, Rachel Patel; Lancer, Professor Lawson; Big Guy, Steven Smith; Smart Guy, ASTRAKAHN-Delta; Chick, Sally Westerham.
Personnel Files 4: Leader, Diego Hughes; Lancer, Paul Chung; Big Guy, Charlie Mallinson; Smart Guy, OVERSIGHT; Chick, Paz Ramirez.
Personnel Files 5: Leader, Mike Harris; Lancer, Denise Walsh; Big Guy, Dave Sheckley (or rather, perhaps, his Robot Buddy Charlie); Smart Guy, Ian Chakrabarti; Chick, Catherine Moltby.
Girl Next Door: Among the various designs of companion/sex-toy bioroids, one type is specifically designed to match this stereotype. Some customers in the setting want that.
Homing Projectile: With advanced computing and widespread microtechnology, even handgun bullets can have some homing capability.
Human Subspecies: Several, ranging from "upgrades" that have slight improvements and are still interfertile with ordinary humans, to "parahumans" that are effectively different species and include adaptations to life underwater, microgravity, or a semi-terraformed Mars.
Justified Extra Lives: Infomorph characters (artificial intelligences and ghosts) are able to store backups of themselves on secure servers — so if their current incarnations die, they can easily be restored (though they do lose their memories of everything that happened since the last backup).
Kinetic Weapons Are Just Better: The trope is front and centre here. Personal laser weapons suffer from power supply problems, whereas bullets still work just fine,
Laser Sight: The settings's advanced firearms tend to include all sorts of aids as standard, including this.
Living Toys: With the advanced AI, robotics, and microbot technology, this trope is trivial to instantiate. However, small toys don't generally have the computer capacity to run self-aware AI.
Longevity Treatment: There are a couple of nanosymbionts that extend life expectancy by ten years or so each. Rejuvenation is expensive and unreliable, but actually reverses aging.
Made of Iron: Submissa series bioroids. Canonically intended for BDSM play, they're actually tougher than the Spartan series Super Soldier bioroids. The effect is less pronounced in Fourth Edition (due to Hit Points being calculated from Strength, not Health).
No Transhumanism Allowed: Largely averted, though various societies ban some transhumanist technologies — the Islamic Caliphate bans ghosts, the European Union bans radical human genetic engineering, and so on.
One-Gender Race: Hyppolyta parahumans, created for a female-separatist space station. Ironically, gender identities have become a lot more fluid since the station was founded, and it's now very easy to switch sex with modern technology, making sexual separatism increasingly meaningless.
Remote Body: A central component of the setting. People, especially AIs, rent (rarely purchase) cybershells designed for their environment or the job they're doing at the moment.
Robot Buddy: Virtually everyone who isn't flat broke or weird has one or more AI assistants, sometimes running on portable or implanted computers but sometimes installed in autonomous robot bodies — so there are a lot of robot buddies around.
Robot Dog: At least one of the many "cybershell" body types available to run AI software on is the "Cyberdog."
Robot Girl: The thousand-and-one varieties of "cybershell" inevitably include some made to look like attractive female humans — sometimes for relatively innocent reasons, sometimes not.
Sleeper Starship: Nanostasis is routinely used to save on life support during interplanetary voyages, although nobody has attempted manned interstellar flight yet.
Sliding Scale of Robot Intelligence: We have non-sapient AI (NAI), low-sapient AI (LAI), and Sapient AI (SAI). Also, baseline AI template IQ is dependent on program complexity.
Space Elevator: There is one on Mars, and another one being built on Earth.
Straw Feminist: A trope that is played with in the depiction of "Margaret", a space station founded by radical feminists which only permits female biological visitors or residents. It's generally accepted in-setting that, in a solar system where people can and do change sex temporarily for fairly trivial reasons, and the big civil rights debates involve artificial intelligences and biological androids, the Margaretians are still fighting the last century's battles. They aren't depicted as wildly stupid, just stubbornly out of date. They are respected for their women's self-defense classes, which produce some of the most formidable human martial artists in the solar system.
Technically Living Zombie: In the "Orbital Decay" module, this is caused by a combination of three nanoviruses. One that causes living flesh to rot, one intended to create shock troops, and a third that decreases intelligence and makes the infected go berserk.
Terraform: The Duncanites were driven off Mars for starting this without the permission of any of the countries colonizing, the Green Duncanites are attempting to terraform Europa and are at war with a group of environmentalists. By 2100 Mars is not quite Earth-like, but specially adapted parahumans or people with the appropriate biomods can survive without an environment suit.
Transhumanism: Half the title, and at least half the point of the setting.
What Measure Is A Nonhuman: Legal attitudes vary greatly by country. Usually, AIs and uplifts are property and bioroids are treated as more or less permanent minors, while ghosts and parahumans are full citizens, but there are numerous exceptions and variations. For example the EU gives full citizenship to bioroids and SAIs, while the Caliphate treats SAIs as people and ghosts as abominations, for theological reasons discussed inBroken Dreams.