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- By the end of the series Genji Tsuushin Agedama has Agedama, Rei and Ibuki, the third of which is Agedama's Love Interest
- A "switched places" variant on Macross Frontier in the form of "A Guy and Two Girls": Alto, Ranka and Sheryl.
- In the early seasons, Magical Girl Lyrical Nanoha had Nanoha, Fate and Yuuno as the core cast. Atypically, Fate and Yuuno were Nanoha's love interests.
- Soul Eater: Death the Kid is the meister of Liz and Patty. A subversion in that Kid, is the lead (of the partnership) and neither Liz or Patty are in love with him.
- IGPX Immortal Grand Prix: Takeshi, Amy, Liz. A rare example where the one male is The Hero.
- Neon Genesis Evangelion has the initial Three Children: Rei, Asuka and Shinji.
- Sailor Moon began with Usagi befriending Naru and (Gurio) Umino.
- While Tenchi Muyo! is your typical harem anime comedy, the tension is mostly centered on the main Love Triangle of Tenchi, Ryoko and Ayeka.
- No matter the version of Cardcaptor Sakura you go after, there'll always be a girl rounding out the group with Sakura and Syaoran (Kero-chan notwithstanding): if you go for the manga, Tomoyo's always there with them, but in the anime, Meiling is added to the equation.
- Those Who Hunt Elves: Junpei, Ritsuko and Airi.
- The anime adaptation of School Days takes this setup and pushes it past the breaking point with reckless abandon. Two girls, one guy, zero brains. And that's the point.
- Mawaru-Penguindrum has Tabuki, Yuri and Momoka. Both Tabuki and Yuri are in love with Momoka, whom she has known them since they were children. And then Momoka dies/disappears in the Tokyo subway attacks and since this is a Mind Screw series, things get... complicated from there.
- Samui, Karui and Omoi (the guy) from Naruto, in contrast to the overused Two Guys and a Girl formula of the series.
- Log Horizon has the older Akatsuki and the younger Minori vying for the affection of the protagonist, Shiroe.
- Trigun: From the start it's Vash, Meryl, and Milly.
- Scrapped Princess: Pacifica—the main character—and her adoptive siblings, Raquel and Shannon. (The latter two are blood relatives, but Pacifica is an Apocalypse Maiden from the royal family.) Its Spiritual Successor, Coffin Princess Chaika, starts out the same way with Chaika, Toru, and Akari; but it soon adds Frederica to the group, making it three girls and one guy.
- The Trope Codifier and possibly the Ur-Example in comics is Archie Comics, which has revolved around the same Love Triangle between Archie, Betty, and Veronica since 1941.
- Scott Pilgrim: Scott, Kim Pine and Ramona Flowers.
- Strangers in Paradise starts out like this, but it gets... complicated.
- Transmetropolitan: Spider, Channon, and Yelena
- Y: The Last Man, being a Gendercide world, has this setup with Yorick, 355, and Allison.
Film - Animated
- Blu and Jewel's children, Bia (female), Carla (female), and Tiago (male) in Rio 2
- The "secondary trio" in Harry Potter: Neville, Ginny and Luna.
- Phenomena has a quite odd one with Alk and Ilke travel with their friend Millian. Millian isn't interested in either of them as she only looks about 19 and is in love with the twins' friend Azur, and Alk already has a girlfriend.
- Tabitha Twichit's kittens, Mittens (female), Moppet (female), and Tom (male) in The Tale of Tom Kitten
Live Action TV
- Andi Mack: Andi, Buffy and Cyrus.
- A.N.T. Farm: Chyna, Olive and Fletcher. Later on though, Angus joins them.
- Buffy the Vampire Slayer: Buffy, Willow and Xander.
- Doctor Who:
- Hannah Montana: Miley, Lilly and Oliver. Disney was pretty into this trope.
- Hikonin Sentai Akibaranger: Like the Macross Frontier example above, Nobuo, Mizuki and Yumeria.
- House of Anubis: As part of the Three Plus Two dynamic of Sibuna, the main trio is Nina, Amber, and Fabian. While there was some shiptease between Fabian and Amber, it was Fabina that became the main pairing of the show.
- iCarly: Carly, Sam and Freddie (pictured), until Gibby joins them.
- After Carly left for Italy and Freddie stays in Seattle, Sam & Cat has Sam, Cat and Dice.
- Lizzie McGuire: Lizzie, Miranda and Gordo.
- Naturally, Sadie: Sadie, Margaret and Rain.
- That's So Raven: Raven, Chelsea and Eddie. Only once (for each girl) was there ever so much as a Ship Tease; in one of said instances, Raven points out the Unfortunate Implications of what would happen.
- True Jackson, VP: True, Lulu and Ryan.
- Disacode, from 2013 onwards with female vocalist Akira and drummer Marcy and male bassist Shun.
- Gossip, comprised of Lipstick Lesbian Beth Ditto, Butch Lesbian Hannah Blilie and The One Guy Brace Paine.
- Alcazar, comprised of Andreas Lundstedt, Therese Merkel and Lina Hedlund, from 2007 onwards. It was this from 1998 to 2002, when Magnus Carlsson joined.
- Disgaea: Hour of Darkness has Laharl the prince and two girls, Flonne and Etna.
- In Katawa Shoujo, main character Hisao can date one of five girls, each of whom has a best friend who often shows up during her route. The possible "two girls" are Lilly and Hanako, Rin and Emi, and Shizune and Misha (who does not have a route). Though there's a certain and infamous option in Shizune's route that includes her...
- Mitsumete Knight R: Daibouken Hen: while the party is always composed of one guy (MacLeod) and two girls, you can choose which two girls, among a pool of five, will follow MacLeod in the quest. Choosing wisely the two girls is crucial, as they have different battle strengths, and have different relationships between each other (some, like Hanna and Linda, hate each other's guts, leading to crippling Jealousy Events).
- If you choose the female character in Pokémon Black and White, you have Hilda, Bianca and Cheren.
- Skies of Arcadia gives us the famous trio, the Air Pirates Vyse and Aika, and the Silvite Fina. This is played with; Vyse is the leader of the group, and though there is a visible Love Triangle, it is not the main focus of the story, and it strays away from it, leaving it unresolved - given the circumstances, it was handled quite well.
- The Good End of the Unlimited Blade Works route of Fate/stay night has Shirou, Rin, and Saber end up as this with the added bonus of being in a menage-a-trois.
- In Mahou Tsukai No Yoru, you have the main character Aoko, her foil and best friend Alice, and her schoolmate Soujuurou, who claims to like her. Played with in that while Soujuurou has ship tease moments with both of them, only Alice is implied to have feelings for him while Aoko and Soujuurou only become very intimate friends with little to no romantic interest in each other.
- Braceface: Sharon, Maria and Connor.
- Though in the episode "The Pickford Project", Connor was bitter about not having any guy friends and was paired with Alden and Brock. By the end of the episode, Connor's happy with the friends he's got.
- Cyberchase: Matt, Jackie and Inez.
- Kim Possible, Ron Stoppable and Monique (even though she isn't a main character).
- Mona the Vampire: Mona (female), Lilly (female) and Charley (male)
- Pepper Ann plays this pretty straight, Pepper Ann (star), Nicky Little (female opposite), Milo (male just friend).
- Cupcake (female), Rebound (female), and Patches (male) the puppies in the Hub's Pound Puppies (2010).
- Sofia the First plays this straight with Sofia and Polar Opposite Twins Amber and James.
- Thomas And Friends: Annie (female), Clarabel (female) and Thomas (male). Also in the books, there's Alice (female), Mirabel (female) and Duck (male); Isabel (female) Dulcie (female) and Oliver (male) (Dulcie teamed up with Oliver and Isabel later); Henrietta (female), Victoria (female) and Toby (male) (as of 'Thomas and Victoria'). Victoria also had Helena (female) and Albert (male) prior to Toby and Henrietta.
- What About Mimi? had Mimi, Elaine and Russell.
- Wonder Pets has Tuck (a male turtle), Linny (a female guinea pig) and Ming Ming (a female duckling).