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Anime & Manga
- Genom is a Mega Corp. in Bubblegum Crisis that does a lot of R&D to disastrous effect.
- Ghost Hound has a research facility in the hills just outside town, Dai-Nippon Bio.
- Ghost in the Shell has a lot of these: Derumo, Kenbishi Heavy Industries, Kyo-Re, Locus-Solus, Meditech Corp, Hanka Precision Instruments, Poseidon Industrial Co., Serano Genomics, Tokura Electronics, and likely others; all do commercial R&D.
- Pandora Hearts has a Gaslamp Fantasy variation of this: the organization Pandora was made for the express purpose of studying the Abyss, the Chains, the Will of the Abyss, and their impact on the real world. The true object of their research is kept secret from the general public, and the main character only learns the truth after getting thrown into the Abyss himself and being forced to join the organization.
- PANDORA (unrelated to the above example) from Darker Than Black does research on Hell's Gate and may or may not develop technology based on its properties.
- In The DCU, S.T.A.R. Labs (Scientific and Technological Advanced Research) is an independent group of research laboratories throughout the U.S. It has a long history of coming up with high technology and new inventions, and has also regularly gotten involved in superheroic activities.
- In the Heechee Saga, the Gateway Corporation makes all its money by researching applications of alien technology and other discoveries brought back by the volunteers who fly in the mysterious and often deadly alien ships found on Gateway asteroid.
- In the Vorkosigan Saga, The Durona Group was set up by Miles' brother Mark (using some of the millions he got at Jackson's Whole) to research life-extension techniques that will help put an end to the morally repugnant Jacksonian clone-and-brain-swap business.
- Galactic Cybersystems Corporation in The History of the Galaxy had a planet dedicated to R&D.
Live Action — Films
- Antigen in Underworld: Awakening focuses on medical research.
- Bartok Industries starts up where Seth Brundle left off in The Fly II.
- Cyberdyne Systems were at one point the origin of the Terminators and Skynet.
- Bradford Labs in Inspector Gadget.
- Star Wars has Sienar Advanced Projects Laboratory (designed Darth Maul's Scimitar starship) and Czerka Arms, which runs laboratories.
Live Action — TV
- Fringe's Massive Dynamic specializes in biotech.
- Eureka has Global Dynamics, which isn't a true Mega Corp. as it only does R&D with government supervision.
- The Hanso Foundation from Lost has the motto "Reach Out to a Better Tomorrow" and financed the DHARMA Initiative. Mittelos Bioscience doesn't count as it's just a front the Others use for recruitment.
- Doctor Who, being a Long Runner, has quite a few:
- Babylon 5 and Crusade have Interplanetary Expeditions (IPX for short), a private Earth-based commercial company which funds archaeological expeditions to alien planets in the hopes of finding ancient technology to reverse-engineer and incorporate into Earth technology. They sort of dance on the line between outright corrupt and merely kind of dodgy, and the minor characters in B5 and main character in Crusade that we see work for them often aren't the greatest of people even when they're on the good guys' side.
- When The Drew Carey Show gang infiltrates Lewis's workplace of DrugCo we see things like gigantic insects and interchangeable heads. They also offered large amounts of money for a man to test breast implants. Double if they pose for the calendar.
Kate: Does any actual research go on at DrugCo or is it just one big game of "Truth or Dare."
- Better Off Ted takes place in the R&D section of Viridian Dynamics, and they develop everything from artificial meat to killer cyborgs.
- In Helix Arctic Biosystems is a private company staffed by over a hundred Morally Ambiguous Doctorates who specifically come to the base, stationed in international territory, to exploit the opportunity to perform research unburdened by regulatory agencies. Its problems begin when a Synthetic Plague its been developing gets out of control, and results in an outbreak of The Virus amongst its research scientists.
- The Old World of Darkness has a few:
- There are more than a few in the Mega Corp.–dominated Shadowrun.
- Triax from Rifts used to be one of these, but now acts more an arm of the New German Republic.
- In Urinetown, this is supposedly one of the primary missions of the UGC (Urine Good Company), the company that owns and operates the public toilets.
It's mentioned mainly in passing in a musical number:We're not greedy, as some make us seem.We need funds for our big research team.What it shows, no one knows, but hey, still we can dream.
- Abstergo in Assassin's Creed. It also helps make money to keep a secret society going strong.
- Deus Ex has pharmaceutical giant Versalife, which even has secret underground labs.
- Deus Ex: Human Revolution has an entire field of biotech corporations specializing in researching and developing new mechanical augmentations, the most prominent of which are Sarif Industries, Tai Yong Medical and Darrow Industries, the latter of which has shifted to geoengineering to combat global warming.
- Resident Evil initially feature the Umbrella Corporation and later TRICELL, which were both into Pharmaceutical R&D.
- Black Mesa Research Facility from Half-Life competed with Aperture Science for government grants with much more success.
- Aperture Science from the Portal series was this, before GlaDOS killed off most of the employees and assumed direct control. Notably, they were so much more interested in wild experimentation and building insane contraptions than in corporate profit, that the company hit rock bottom long before the whole omnicidal AI outbreak incident.
- A central element of FEAR is the Armacham Technology Corporation (ATC), who's almost entirely responsible for all the problems in the game.
- System Shock has the player run into a lot of products from TriOptimum, a Mega Corp. with a division dedicated to science.
- [PROTOTYPE] and [PROTOTYPE 2] have GenTech, a genetics lab that seems to be directly controlled by Blackwatch, as all of their research, with projects like Blacklight and New Templar are things that only Blackwatch would support. You've got to wonder, where do they find the thousands of mad scientists it takes to run this place, seeing as it apparently is staffed purely by sociopaths and psychopaths.
- The Cities of Tomorrow expansion pack for SimCity introduces "The Academy", a super-advanced facility full of science gurus that lets mayors research expensive, but very useful additions to their cities/region.
- Vector Thrust has Sigsawa Heavy Industries, who specialize completely in research and development of new heavy industry and force-application technology to sell to nations and manufacturers.
- A villainous example from Mass Effect: Binary Helix, a corporation primarily owned by arc villain Saren, invests heavily in (as the name implies) genetics research — meaning it's the source of the entire incident on Noveria with the rachni, Saren's genophage cure, and most of his Offscreen Villain Dark Matter.
- Hereti-Corp from Sluggy Freelance even programs their muffins to self-destruct lest they fall into the hands of a competitor.
- Cassie's workplace in Times Like This is TerCon Technologies, a nanotech laboratory. The products that she says "may happen in the future" at the conventions are generally ones she's actually witnessed while time-tripping in the future.
- The SCP Foundation has a dedicated research staff who study the paranormal, primarily to figure out how to track down, capture and safely contain the things they've already encountered, secondarily to try to figure out how the paranormal in general works, and thirdly to figure out how to use the paranormal to create resources the Foundation can use (which is part of the reason the Foundation is an Organization with Unlimited Funding).
- Played even straighter with Prometheus Laboratories, one of the groups of interest tracked by the foundation. This GOI is a rather sketchy research group with a great track record on figuring out how to turn anomalous effects into even more anomalous devices... and not such a great track record on things like remembering to add an off switch to an infinite power source.
- Yoglabs from "Let's Play/Yogscast" is mod testing disguised as this.
- Institutionalized R&D started around the 1790s in France, but didn't get going until the 1860s in the USA with the Cambria Iron Company, followed by the Pennsylvania Railroad, and eventually the famous Thomas Edison Electric Light Company. By World War II, most countries involved had research labs to make bigger and better weapons, and the Cold War is famous for its Lensman Arms Race, with Western R&D not in the hands of governments so much as private contractors. Nowadays this trope is ubiquitous, and R&D itself is an essential part of our technological society.
- The RAND Corporation is an especially famous example of the trope in action. The name literally stands for Research ANd Development. Originally formed to offer research and analysis to the United States armed forces, its scope has grown to encompass pure science including space exploration; civil and criminal justice; social policy including child welfare; public health; and many other areas. Thirty-two Nobel laureates have been associated with RAND at some point in their careers.
- German industrial corporation Robert Bosch GmbH. In its core automotive technology business, Bosch invests 9% of its revenue on research and development, nearly double the industry average of 4.7%. The other wiki has more information.
- The pharmaceutical industry probably takes the cake on the research front, where most companies invest around 10-20% of their revenue on R&D.
- Defense contractors are pretty noteworthy for R&D spending as well, investing 10% or more of their profits (not to mention their notorious cost overruns).
- Bell Labs, who invented the first transistor (and later, the MOSFET), the photovoltic cell, radio astronomy, lasers, the C programming language, the UNIX operating system, and much more, racking up 7 Nobel Prizes in Physics in the process.
- One that often surprises people: Microsoft, amazingly enough and despite their reputation. They have an absolutely insane R&D budget that accounts for something like 15% of their revenue. It's also considered one of the unfortunate jokes of the IT industry that despite having one of the biggest and best research divisions in the world, the corporate division steadfastly refuses to actually produce any of their best ideas.
- IBM's R&D/revenue ratio is more like 7%, but they've had five Nobel laureates and as 2017 have patented more inventions in the US than any other company for twenty-four years in a row. Suing IBM for patent infringement is considered a bad idea, because they generally call up their Army of Lawyers, have them take a look at your stuff, and say to your lawyer something like "Yeah, about that one patent of yours we're supposedly infringing . . . do you want to talk about the fifty patents of ours you're definitely infringing?"