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Anime and Manga
- This is the main premise of the first Vampire Hunter D movie and novel, with the heroine hiring D to help her, complicated by the fact that her entire town is not only aware of the danger a Vampire Refugee can pose but actively on the lookout for them.
- But subverted in the second movie. Although D and the Borghoff Brothers assume she's been carried off against her will, Charlotte Ellborne actually wants Meir Link to transform her into a vampire in order to facilitate their love affair. Especially interesting because Carmilla seems to view their relationship as a way of fostering better relations between vampires and humans .
- Well, that's what she claims. In actuality Carmilla is brutal and bloodthirsty even by vampire standards, and only cares for humans for their blood. The whole purpose of her involvement in the enterprise was to resurrect herself with Charlotte's blood. Meir (Myer?) of course wasn't aware of this.
- There are a few in the Marvel Universe, including current vampire hunter Hannibal King and deceased hunter Rachael van Helsing (indeed, being converted can be a frequent job hazard for a vampire hunter in Marvel, or in King's case, what drives one to such a calling). Jubilee is the most recent example of the Trope, although Wolverine, Emma Frost, and Cyclops have not given up on the possibility that she can be cured.
- 30 Days of Night had the sheriff injecting himself with vampire blood to become a "Good Vampire" (barely controls it and he kills himself shortly after) to beat the bad guys.
- Andrew Bennett from House of Mystery's "I... Vampire" series straddled the line between this trope and Doomed Moral Victor. Though he did jump at the opportunity for a cure when he chanced upon one, for most of his unlife Bennett harbored no hope of restoring himself, and was preoccupied with exterminating a bloodline of evil vampires he'd mistakenly sired, by converting his onetime lover. To survive, he bought blood by the bottle from street people.
Films — Animated
- In The Batman vs. Dracula, our hero finds a cure for vampirism, but it won't work on Dracula himself — just those he's turned.
Films — Live-Action
- Horror of Dracula has Harker, who in this version is actually turned into a vampire. Helsing grimly has to stake him.
- Rise: Blood Hunter: Though Sadie is very determined to get revenge for her unwilling (and unplanned) vampirisation on the bloodsuckers of L.A., she slips when it comes to feeding on a poor schlub offering her a lift.
- The Star/Laddie subplot of The Lost Boys. "YOU TRIED TO MAKE ME A KILLER!"
- The Fly (1986) has doctor Brundle try to reverse the onset of the creature he's becoming. He fails.
- The 1989 sequel The Fly II with Brundle's son Martin does get to stay human though. Albeit by dumping the fly genes into the Corrupt Corporate Executive, making him a mutant slug, kept alive for study in a dark pit.
- The first Blade movie had the vampire antidote for the Girl of the Week. Interestingly, it seems this cure sticks around, and at least two more characters get cured of vampirism in the sequels. However, it can't cure the eponymous character of vampirism without taking away his nifty powers (he just uses a serum to suppress his vampiric bloodlust), nor can it cure anybody who was born a vampire. It can only cure vampirism if one contracts it via a bite.
- Incidentally, it seems that the girl became much more bloodthirsty (or downright sadistic) after the cure was applied.
- Nick from The Forsaken. It is heavily implied in the movie that all vampire hunters have always mostly consisted of people who have been bitten. The rules of vampirism state that all potential vampires are freed from their curse if the "head vampire" who originated that strain is killed (an idea mocked in the Vampire: The Masquerade – Bloodlines video game).
- Cursed is the werewolf version of this trope.
- Van Helsing, turned into a werewolf, must kill Dracula as a werewolf (as was prophesied), but Carl and Ana have to get the cure for lycanthropy to him before the stroke of midnight (as that's when he'll permanently be a werewolf). Fortunately for Van Helsing, the stroke of midnight lasts about twenty minutes.
- In Ginger Snaps Back: The Beginning, Ginger is given a prophecy saying she will need to kill the infected child that bit her to avoid becoming a werewolf herself. In a subversion, the prophecy meant that she should kill the child "before" he bit her.
- Return of the Living Dead 3 featured the heroine finding new and interesting ways to cause physical pain to keep from succumbing to her desire to eat folk.
- Rayne from the first Resident Evil film gets bitten early on. She spends the rest of the time kicking ass to get everyone out and be able to administer the cure to her. Too bad they're too late.
- Most of District 9 involves Wikus panicking about turning into one of the Humanoid Aliens that are poorly treated refugees in Johannesburg, before coming to his senses.
- Lucy Westenra and Mina Harker in Dracula. For the former, it wasn't known what was weakening her till Van Helsing was called in. She would've probably been cured were it not for a few too many bad circumstances. Mina is a bit more fortunate, since Dracula has to flee before he can fully transform her. She feels his presence within her spying on the hunters. And, when confronted by the brides near the end of the story, senses the vamprisim welling up in her.
- The Dresden Files features The Fellowship of Saint Giles, individuals who've been bitten by Red Court vampires, gaining a portion of their power and their vampiric blood lust. However, since they haven't actually killed anyone by feeding, they haven't turned into the horrific bat-demons Red Court vampires really are. As part of their membership, they gain magical tattoos that help them keep the hunger in check and turn darker as they start to lose control.
- The Good Ghouls series — the main character gets turned into a vampire and finds out the only way to get turned back is to kill her own maker. Several problems: firstly, it has to be her who kills her maker; secondly, any vampire higher up the chain, including her maker, is immune to any frontal attack from a lower-ranking vampire, so she has to be sneaky; and thirdly, she doesn't even know who turned her. In the end, she finds out who did it, but someone else kills him for something unrelated, so she's stuck as a vampire.
- Darren of Cirque Du Freak spends a vast majority of the series as a half-vampire. The perks are pretty good on paper, and though he feels lonely at first for not fitting in with either humans or vampires he eventually finds a home and even a destiny with his new species. It's only nearing the last arc he starts to undertake 'The Purge', or a weird sort of puberty, where his human side is finally subsumed by his vampire half.
- Igor Dolinsky in Night Watcher. All the other "true vampires" qualify as well, as they are the ones who no longer need blood, though they aren't human anymore either (but then, neither is Igor, strictly speaking).
- Kostya in the Nightwatch series is the only vampire to achieve "High Vampire" status without killing someone for blood. He became a biologist to prevent his vampirism from turning him into a monster. By the third book, he even tries to turn every human being on the planet into Others just so he could be normal. He fails.
- In the Ravenloft novel Vampire of the Mists, Jander Sunstar was desperate to find a cure for his vampirism once he finally managed to become free to seek that cure. He was heartbroken to learn that there was no cure other than true death (and possibly not even then).
- Moreover, his specific background makes this grimly hilarious: until the mists took him, as a Gold Elf back on Faerun, he was very close to the cure for undeath for all of those centuries. He didn't even know about its existence mainly because the elves treat High Magic as the greatest secret of Multiverse even when they know it's an Open Secret to the present company, and he was just a young adventurer hanging out with humans at the time.
- Granny Weatherwax in Carpe Jugulum is a truly epic subversion. After getting bitten by a bunch of Vampires with the express purpose of turning her into a vampire as well - making her a slave to the vampires having "sired" her - she goes through the usual trappings: Making a stressful journey in order to find the vampires responsible, organizing weapons (or rather: friends with weapons), and nearly dying several times while fighting the effect of the turnings. In the end, it turns out not only was she fighting off the turning the whole time, she was also "borrowing" (a form of passive possession) her own blood in order to make the vampires who drank from her crave tea and sweet biscuits, or, in her own words: "I ain't been vampired. You've been Weatherwaxed!"
Live Action TV
- One episode of Odyssey 5 had Taggart becoming a Synthetic, a nanomachine/cyborg/android. He and his friends try to reverse it, but in the end he manages to hack the Deus Est Machina that made him into reverting the process.
- Dr. Kevin on The 4400 experimented on himself with Promicin to give himself powers. He got very mutated at first, but then found the cure for that.
- The eighties show Werewolf was built around this premise.
- Maya on Heroes was desperate to get rid of her Superpower Of Involuntary Mass Destruction. Subverted in that she didn't have an Action Girl bone in her body.
- Gordon had the perfect set-up for becoming a Vampire Refugee, but since he knew there was no way to undo the change, he decided instead to kill Sam and then himself. Instead, Sam killed him.
- In season 6, this trope was played completely straight as Dean gets bit, angsts, kicks some ass, and then gets cured at the end of the episode.
- On My Babysitter's a Vampire, Sarah (the babysitter) was turned into a vampire by her boyfriend. However, she refuses to eat humans and exists on animal blood or blood substitutes while trying to find a cure.
- In the first episode of Angel, it's pointed out to our hero that he must do this out of necessity. Even if you're a fighter against evil, you can't afford to isolate yourself from the people you're trying to protect as you'll eventually stop caring and revert back to a monster. Angel thus gathers his Ragtag Bunch of Misfits so he'll have some Fire-Forged Friends keeping him grounded.
- Mage: The Awakening features rare wizard refugees in the form of the Banishers. Banishers had their Awakening go wrong in some way or another (it's suggested more than a few of them literally gazed into the Abyss); as a result, the very use of magic causes them revulsion, and they spend much of their time hunting down and killing other mages out of the belief that magic is, at its core, evil.
- In Vampire: The Masquerade, vampires would occasionally seek out Golconda, a mystical state of transcendence. Nobody could agree on what Golconda was, but one persistent rumor was that it would allow you to shake off the Embrace and become mortal again. One scenario had the villain trying to eat his way up his "family" tree to cure himself.
- One of the paths involves Shiki being increasingly possessed by an ancient vampire sorcerer, gaining the usual powers and bloodlust as his will rapidly erodes, and having to defend himself against his former companions. At first he holds out for a solution from the Church, but when that doesn't pan out he resorts to his solution to everything else—turning his Mystic Eyes of Death Perception on and stabbing himself in an attempt to 'kill' the vampire's soul.
- Sion Eltnam Atlasia is entirely based on this. She even goes as far as to create an alchemical substitute for blood to deal with her cravings as a temporary measure. (It works, but only because of the extenuating circumstances.)
- This becomes an optional quest in The Elder Scrolls if the hero becomes a vampire. In Daggerfall, it is offered by a vampire hunter who give you a choice instead of killing you (you can also drink the potion a witch coven asks you to transport). In Morrowind, it is given by reading a book about a cured vampire and doing a favor for Molag Bal, the "patron" daedra of vampires. In Oblivion, it involves collecting a long list of ingredients to make a potion. In Skyrim, it involves trapping a human soul in a Black Soul Gem and giving it to a sorcerer, who sacrifices the soul to Oblivion as payment for your vampirism to be lifted.
- The plot of Neverwinter Nights 2: Mask of the Betrayer involves trying to get rid of the Spirit-Eater curse, at least for a good-aligned character.
- Vampire: The Masquerade – Bloodlines features a "thin-blood" down by the beach who's desperately trying to find a way out of his new condition. You can either a) let him down easy and tell him that he can at least try to go on (un)living, or b) bilk him for all he's worth by selling him a "stake of pure rosewood" he can use to kill the "head vampire" or some vampirism-curing "unicorn blood." Or both.
- Batman: Arkham Knight has a rather unique version of this. After having been contaminated with the Joker's infected blood in the previous game, Batman's mind is slowly starting to be taken over by the Joker. He has four other infected patients locked up in a satellite Batcave, one of whom is showing no signs of any Joker-like symptoms, and is being used to develop a cure. Throughout the game, visions of the Joker taunt you at every possible moment, and at several moments (especially when Batman gets exposed to Scarecrow's fear toxin), Batman loses control, and the "Joker" part of Batman's mind actually manages to take over.