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Individual Games: Danganronpa | Fire Emblem (Awakening | Three Houses | Engage | Heroes) | Genshin Impact | Honkai: Star Rail | Persona | Super Smash Bros.
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- Labyrinth of Refrain: Coven of Dusk: Atalanta, a cold-hearted witch, and Yusa Kurobane, her cute and constantly put-upon assistant, send puppets down a well to gather magical artifacts from a dungeon. They were also briefly opposed by Hirito.
- L.A. Noire: Ken Cosgrove starts out as a patrolman who rises through the ranks and has Corporal Hawkins, Salinger, and Agent Walker as partners before he's demoted to arson where he works with Harbinger. At least half the cast of Mad Men are interrogated, and other suspects include Unicron and Matt Parkman. Denethor and Micah Bell are behind the overarching conspiracy.
- The Last of Us: Kanji Tatsumi is a rugged post-apocalyptic survivor, making his way past a zombie apocalypse, alongside his brother Joseph Turner and his partner Renee Walker. Kanji's life changes when he is contracted by Alyx Vance to escort Gwen Tennyson to her group. Kanji and Gwen meet Desmond Miles along the way.
- League of Legends: After war wrecks the land of Runeterra, the nations decide to do diplomacy by making their greatest heroes and villains fight each other. These include Lust, Roy Mustang, Edward Elric, Nazz, Billy, Kazuko Saotome, Mami Tomoe, Sweet Tooth, Keith Shadis, Mitabi Jarnach, Levi, Allie, a Protoss Zealot, Koga, Kaliban, Kondraum, Ben Tennyson, Frankie the Rat, Rouge the Bat, Guile, Fei Long, Rolento, Poison, Kallen Kozuki, Charles zi Brittania, Heinkel Wolfe, Astaroth, Ragna the Bloodedge, Iron Tager, Noel Vermillion, Arakune, Bullet, Scorpion, Teen Gohan, Cell, Broly, Kamina, Invader Zim, Daggett, Proton Man, Waspinator, Omid, Clementine, Hershel Greene, Tavia, Magiquone, Ivan, Jo Bennett, Megan, Sakura Haruno, Tobi, Jiraiya, the game's Audio Lead developer, Bane, Colonel Moore, Abaddon, Syphon, General Mikiel, Pit, Roadhog, Villamax, Chrom and Female Corrin, Maiko Ogure and Blue, Josephine Baker, Ravus Nox Fleuret, Timon, Stephanie, Peacock, Aunt May, JORN, Bigby Wolf, Faith, TorqueDawg, Thor, Tron Bonne, Galactus, BlackRose, Sam, Rin Hoshizora, Princess Leia, Darkstar Three, Ritsu Tainaka, Aya, Chen Gong, Darcy, Colin, Ace, Armand Bouchart, Amagi, Bryan Fury, Kuai the Brute, Magilou, Candence, Steel Scarab Khepri, Augustus Sinclair, Asajj Ventress, Harley Hartwell, Shinji Ikari, Batou and Kain Highwind.
- And guess what? This isn't even all of them! (It's roughly about three-quarters.)
- Out of interest, Waspinator used to be Clyde, Tavia used to be Painwheel, JORN used to be LeChuck and Roadhog used to be Kenpachi Zaraki.
- Left 4 Dead: Detective David Tapp, Father Grigori, Cortana, and Joey Cospito are four ordinary people who fight through hordes of zombies, which include the lead singer of Faith No More, the Thing, Squilliam Fancyson, and GLaDOS. Along the way, they are helped by William the Kid and Heavy, but Spy and Scout turn out to be infected.
- Left 4 Dead 2: O.J. Simpson, Cpl. James Chaffin, Cole McGrath, and Grace Russell are the new survivors.
- LEGO City Undercover: Perdido returns to LEGO City after a 2-year absence after exposing Faith as a secret witness in a trial against Jaguar only to find out Jaguar has escaped and LEGO City is overrun with crime. With the aid of disguises and a police communicator provided by Triss, Perdido must stop Jaguar's plan and bring him back to jail. Avitus Rix is an incompetent recruit, Rufus is the police chief, and Kang the Conqueror is a billionaire and Jaguar's boss.
- LEGO DC Super-Villains: King Frederick breaks out of prison with the help of a mute and Cleo. Meanwhile, Luke Skywalker and Twilight Sparkle team up with a bunch of other villains to rob the Gotham City Police Department. Things go pear shaped when a team of Super Villains masquerading as Heroes led by A Defective Turret trap the local superheroes, led by Colonel Roy Mustang, in an alternate dimension. Now King Frederick, Luke Skywalker, and a bunch of other villains must stop them before they bring General Jack Granger to earth.
- LEGO Dimensions: On his quest for Foundational Elements, the evil Commissioner Gordon merges the worlds in The Multiverse into one. It's up to Miri, Professor Utonium, and Espio the Chameleon to recruit other characters stop Gordon's plot. Among said characters are Goddard, Stuart Macher, Frankie Foster, Abu, Natalie, Red Herring, Captain America, Merasmus, Chun-Li, Red Skull, Mojo Jojo, Leeron Littner, and Infinite.
- The Legend of Zelda: Breath of the Wild: The Japanese Donatello wakes up after a long sleep, beckoned by the voice of Princess Ash. Now, Ash, with the help of Donatello, deceased Champions a Moogle, Caulifla, Cheetor and Guido Mista, and new Champions a Kingsglaive, Sae Niijima, Pesci and Kinger, must save Hyrule from an ancient evil. Aiding them are Sheikah elder Jane Jetson, ghostly king Brock, Sheikah scientist turned child Sakura Haruno, and Wise Tree Kiyotaka Ishimaru. At some point, Donatello ends up fighting the Japanese Hop Pop.
- Hyrule Warriors: Age of Calamity: A small guardian named Terrako goes into the past to help Donatello and Princess Ash Set Right What Once Went Wrong, alongside a younger Jane. Along the way, they join forces with the Champions as well as the Korok Kotori Minami, and receive assistance from Sakura and her brother Falco Lombardi. They end up fighting the evil sorcerer the Iron Giant, while also dealing with Hop Pop, who is now Sombron, and his henchman M. Bison. The new guardians also go back in time to help. Vicki Vale, Miradox, Wilhamena and Megumin are a group of Great Fairies, Ragna the Bloodedge is a horse god, and Jeunan Avertif is a Sheikah monk.
- The Legend of Zelda: Tears of the Kingdom: Years after Breath of the Wild, Donatello and Ash discover the revival of Demon King Beelzemon, resulting in a weakened Donatello having his arm replaced with that of Dimitri Alexandre Blaiddyd. Donatello must now fight alongside the Sages, which consist of the Kingsglaive, Sae and Pesci from the last game, as well as Riolu, Yukari Takeba, and the aforementioned Dimitri. Meanwhile, Ash is sent into the past where she meets Dimitri and Yukari, as well as Queen Asuna Yuuki. Astgenne is Sakura's assistant.
- LEGO Marvel Super Heroes: When cosmic bricks are scattered all across the Marvel Universe, Ratchet, Sonic the Hedgehog, Saren Arterius, Roy Mustang, Jamie, Joel, Tohru Honda, Klaus, Lexaeus, and Cecile Horton are among the heroes assembled by Tiger's Eye to recover them before they fall into the hands of Solomon Grundy and Yuri Lowell. Eventually, the heroes must join forces with Grundy and other supervillains to fight Bender Bending Rodriguez.
- LEGO Island: Andy Davis, the adopted son of Grandmother Fa and F.B.I. Agent Hunt, competes in races with Lenny the Lyre Bird and Augustus Sinclair, and then he helps the cops arrest Smart Ass.
- Let It Die: Linka operates an elevator for you.
- Life Is Strange: Iris/Rose Campbell is a Time Master who saves Aloy from being gunned in the girls' bathroom by Tucker. The main Blackwell students include Harriet Smith, Emogene Cabot, and Jaden. Damien is the principal of Blackwell. Sabrina Hepburn is the chemistry teacher. Aloy's mother, Katjaa, is married to Guard Wiley, and her deceased father is Professor Harold MacDougal. Elder Maxson is both a creepy janitor and a famous teacher who owns the Dark Room.
- Lollipop Chainsaw: Harley Quinn is a chainsaw-wielding cheerleader who fights zombies while carrying the still-living (courtesy of some magic taught by Shang Tsung) severed head of her boyfriend The Flash on her belt. Harley's sisters are Velma Dinkley and Shinobu, and her parents are Winston Wellesley and Olga Gurlukovich. Together, Harley and The Flash must fight baddies such as Jimmy Urine, Merle Dixon, Amanda Young, Pong Krell and Thor, in order to stop Kirk Gleason from summoning Kakuzu.
- Looney Tunes: Back in Action: Plucky Duck and Grandpa Lou Pickles are sent on a mission to retrieve a blue monkey-shaped diamond from the nefarious Acme Corporation, led by the nearsighted Droopy.
- Lost Dimension: The Dark Magician leads a crack team of psychic-powered specialists, including Kasumi, Joseph Joestar, Agnès Oblige, 2B, Shadow the Hedgehog, and XJ-9, to defeat terrorist Levi Ackerman, but some of the Dark Magician's team may be traitors, and he must use his own abilities to discover whom.
- Lost Odyssey: Bloo, an anmnesiac immortal, was sent on a mission for the empire to check one of their magic engines by LeFou. He is joined by Twilight Sparkle and Knuckles the Echidna. On his way, he met up his grandchildren Sally Acorn and Asajj Ventress, the immortal queen Ingrid Hunnigan and his long forgotten wife Dawn Star. Eventually, it turns out that LeFou was also an immortal and the reason behind the reactor's malfunction and their memories being lost.
- Love Nikki - Dress Up Queen: In a world where fashion shows are Serious Business, Tomoyo Daidouji embarks on a quest to become the best fashionista in the land.
- Lux-Pain: After a traumatic accident that took his family, Abel becomes a telepath and joins an organisation created to hunt down mental parasites, led by Kyoya Ohtori and co-ordinated by Monkey D Luffy. He arrives in Kisaragi City with his colleague Ayame Sohma and assisted psychic sensor Mirajane, who has a huge crush on him. Between his investigations he settles into the nearby school with his classmates, including Mr. Spock, Ms. 'Splosion Man, Kaoru Hitachiin and Sweden. Eventually he confronts the strongest of the parasites, buried within the minds of an old man, Gelb and one of the Street Fighter announcers.
- Another way of looking at it: Abel's fellow members of FORT are Zarbon, Young Gohan (who is also Android 18), Bulma and Vegeta.
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- Madagascar: Cubot, Wilt, Alisa Carmichael, and Wilhuff Tarkin are four zoo animals who end up stranded on the island of Madagascar, where they meet King Reaper the lemur and his subjects Shredder and Bubble Bass. The director of Megamind leads a group of secret agent penguins who help Wilt escape from the zoo. Axel is a cranky parrot, Kip Biederman is a burly sailor, Sleepy is a warthog with a crush on Alisa, Monkian is a Russian crocodile that Wilt runs afoul of, and Hulk is the leader of the fossa that constantly attack Reaper and his subjects.
- Madworld: Jamie, armed with a chainsaw, enters a very brutal and corrupt tournament orchestrated by "Howling Mad" Murdock. Montana Max is caught in the crossfire and Killer Bee is amongst the mightiest of foes. Featuring hilarious commentary from Sandman and Bob the Builder.
- Mad Dash Racing: A wacky foot racing game starring many characters including Ren and Stimpy, Mario, Fowl Mouth, Rancid Rabbit, Phillip J. Fry, Elmer Fudd, Doug Funnie, Muttley, Bashful, Sam Melvick, Popeye, Principal Rizinski, and Ms. Rose.
- Mafia II: After getting back from World War II, Stephen Strange hooks up with his old friend, Harvey Bullock and ultimately joins of the Mafia. Among the bosses that rule the city are Lion-O, Colossus, and Superboy. Lou Buttafucco is an associate of Strange and Bullock's. Stephen is sent to prison for six years by Commissioner Gordon, where he meets Austin Buckell, Iron Man, and Mugen. Rebecca Stein and Beth Oblong are Stephen's mother and sister respectively, Jackie Estacado is Stephen's brother-in-law, and Jackie Chan is a Triad member. During a break-in Stephen and Harvey have a run-in with Nightcrawler.
- Makai Kingdom: Kyon, the most badass overlord in the Netherworld, destroys it when he gets enraged by Rei Ayanami insulting him through the Sacred Tome. In order to get his body back after confining his soul to the Tome and pushing out Mithos Yggdrasil in the process, he has to take over Rei's netherworld, along with those of such other Netherworld luminaries as Vulcanus, Iron Tager and Axel.
- Magic: The Gathering Arena: Dimension-hopping wizards fight each other. The closest thing to protagonists are the group known as the Gatewatch, including the Living Guildpact Deadpool, warrior of justice Azir and ghost-hunter Leblanc. One of the main settings is run by guilds, whose guildmasters include Leblanc, the mysterious shapeshifter Alucard, Grand Arbiter Medic, the anarchist Avan Hardins and the demonic showstopper Reinhardt, as well as one that is de facto run by David Walker on behalf of a dragon. Other dimensional travellers include the Cool Old Lady pyromancer Lucrecia Crescent, the vampire Jeremiah Gottwald, the dragon mage Spike Spiegal, the beast-summoning mermaid Vex, the nightmare sculptor Orochimaru, the artifice master Geras and his boss, the evil elder dragon Wrecking Ball.
- Mana Khemia: Alchemists of Al-Revis: Kain Highwind is a young man raised by a cat. One day, he was invited to an alchemy school. His friends in the school's workshop include Saber, Yui Hirasawa, Mithos Yggdrasil, Ansem, Seeker of Darkness, Widdershin, Estelle, and an alien named Jaken.
- Marvel Heroes: When Ecliptor gets his hands on a very powerful cube, S.H.I.E.L.D. agents Goliath and Reese Marshall gather a bunch of superheroes, including Jackie Estacado, Killer Moth, Clayface, Lex Luthor, Drake Parker/Prince Eric, and Leeron to stop Ecliptor and his allies, as well as other villains including Clayface's adopted brother Holland and the master of magnetism Obi-Wan Kenobi.
- Marvel Ultimate Alliance 2: Optimus Prime and Breakdown have a political quarrel that's interrupted by nanomachines who end up turning Sesshoumaru into an evil cyborg.
- Marvel vs. Capcom 3: Naraku and Legion team-up to conquer their respective universes. Unfortunately for them, their plans have unleashed another threat from Naraku's universe: the Planet Eater known as Atrocitus.
- From the same universe as Naraku and Atrocitus: The shield-wielding Super-Soldier Zartan, the Powered Armor-clad Hiro Hohara, the God of Thunder Arishok, the savage Saren Arterius, and his cousin Theresa Russo are part of a team of superheroes who have to deal with enemies like the move-copying Vilgax and A.I.M., led by Jon Arbuckle. The telepathic and telekinetic Sheena Fujibayashi, the feral Guilmon and his Opposite-Sex Clone Raven, and the weather controlling Haku are part of another team of superheroes who regularly deal with enemies like Darwin, the Master of Magnetism, the mutant-hunting robot series Bertrand, and Smokescreen, the Merc with a Mouth. Hercules is a young man with spider-like superpowers, Jarod is an Eldritch Abomination, and the Red Guy is an alien with the powers of the Fantastic Four (whom regularly oppose Naraku, Red Guy, and Atrocitus). For DLC, Happosai is another Eldritch Abomination.
- From Legion's universe: Shinji Hirako is a member of the BSAA and opposes Legion, Kamina is a wandering martial artist, Maka Albarn is an Interpol agent, Petr Capek is Kamina's Evil Counterpart, Fuijko Mine is a spy, Arthur Griffin is the mayor of Metro City, Vash the Stampede is Dr. Wily's final creation, Anna Williams is a genius pirate, Ken Masters is a demon hunter, Artificial Demon Judy is Ken's lover, Cell is a cyborg commando, Mikado Ryugamine is an Ascended Fanboy, Cobra is a knight, Wendy Earhart is a succubus, Asuka Kazama is a Cat Girl, Lisa Fukuyama is a jiang-shi. There's also a sun goddess wolf and for DLC, Anemone is an ally of Shinji's who is Brainwashed and Crazy by Legion.
- Ultimate Marvel vs. Capcom 3: All of the above (including Happosai and Anemone) are joined by...
- From Naraku and Atrocitus's universe: Archer Captain Atom (who's a teammate of Zartan, Hiro, Arishok, Saren, and Theresa), Sorcerer Supreme Vito Scaletta (who regularly deals with creatures like, and including, Jarod and Happosai), the motorcycle-riding Spirit of Vengeance Dennis Booker, Heroes for Hire founder Nightwing, Nova Corps member Van Kleiss, and alien raccoon Space Police officer Malchior.
- From Legion's universe: Ken's twin brother Eric Myers, photojournalist Dark Specter, ninja Brad Garrison, and lawyer Donatello. There's also a mutant zombie who's crossed paths with Shinji and Anemone and a gargoyle who's crossed paths with Cobra.
- Marvel vs. Capcom: Infinite: The genocidal androids Slam Bradley and Tank-Top Tiger team up, even fusing into one. To stop them, the heroes of the universes must turn to Wonder Woman's adopted father, Soundwave (who's obsessed with Jibanyan), for help. Zartan, Hiro, Saren, Kamina, Shinji, Ken, Wendy, Brad, Vash, Captain Atom, Dark Specter, Cobra, Arthur, and Cell remain the same, but now Arishok is Two-Face, Malchior is Mr. Chang, Hercules is now SwaySway, Vito is Gaara, Maka is now Sasha Braus, Van Kleiss is now Eugene Horowitz, Dennis is now Max Modell, and Jarod is now Samurai Jack. In addition to Wonder Woman, they're joined by Sigint, the Baroness, Koukin Shuuyu, Khyber, Clementine, Zartan's former sidekick Robin, spy (and teammate of Zartan, Hiro, Two-Face, Saren, Captain Atom, and Signit) Rayne, and the symbiotic Zerstörer. Additionally, the gargoyle is Cheetor, the mutant zombie is now Quincy Fisher, and Bulkhead is a plant creature that helps Wonder Woman and Mr. Chang.
- Mass Effect:
- Mass Effect: Jethann (or Bastila, depending on your gender) is asked by Sgt. Foley and Lockdown to defeat Kakuzu, a rouge Citadel agent who is assisted by Demona, before he ends humanity. To accomplish this, Jethann/Bastila creates a team consisting of Cookie, Oracle, Scott Evil, Karin, Lance Brooks, Anna-Marie, and Scorch.
- And Bastila can have sex with Carth Onasi. Curious implications, there.
- Mass Effect 2: After dying in an ambush from a species known as the Collectors, Jethann/Bastila is revived by President Josiah Bartlet's organization to investigate themi and their connection with the Reapers. Accompanied by Kate Morgan and Nathan Hastings, Jethann/Bastila puts together a team of specialists including Lance, Anna, KO, Leeron Littner, the Nutcracker, and Eruptor to stop their threat. In the process, the team gets a surprising additional membber in the form of Albert Wesker. Jethann/Bastila also gets a new ship with Black Cat as a helpful AI.
- Mass Effect 3: With Earth under invasion by the Reapers, Sgt. Foley has Jethann/Bastila reinstated under alliance miltary to put a stop to the threat. He/she reunites the old team of Carth/Oracle, Anna, Lance, Karin, and newcomer Kanan Jarrus, while Black Cat gains an artifical body to begin assisting the team on assignments. Atrocitus also can join the team. However, President Bartlet has employed Batman as his new enforcer to get in the team's way.
- Mass Effect: Jethann (or Bastila, depending on your gender) is asked by Sgt. Foley and Lockdown to defeat Kakuzu, a rouge Citadel agent who is assisted by Demona, before he ends humanity. To accomplish this, Jethann/Bastila creates a team consisting of Cookie, Oracle, Scott Evil, Karin, Lance Brooks, Anna-Marie, and Scorch.
- Master Detective Archives: Rain Code: K1-B0 is an amnesiac Master Detective for the World Detective Organization who solves seemingly impossible mysteries alongside his ghostly partner Dori. They work with the Nocturnal Detective Agency under the guidance of Ichiban Kasuga, whose members include fellow Master Detectives Luke, Kagetsu, Nozomi Kaminashi, and Haru Okumura, each of whom have special detective fortes that help them solve mysteries around the world. In their way however is the shady MegaCorp that runs Kanai Ward known as Amaterasu Corporation, whose peacekeepers are headed by Hikari Ku and his second-in-command Eleonora Yumizuru
- Mega Man 11: Numbuh One, helped by his creator Mycen, his sister Loona, his dog the Honest Trailers epic voice guy and the goofy robot Boey, must stop Ted Viking's new plan to use Mycen's robots Necalli, Natsu Dragneel, 2011 Illumi Zoldyck, Optimus Prime, F.A.N.G, Silque, Spandam and Cody to conquer the world thanks to an old grudge.
- Mega Man X7: Kyo Kusanagi and Iori Yagami must team up with newbie Anna Williams to stop their new foe Barry Burton and their old enemy Xion. They are lead by Alucard and have the support of Alice Nonomura.
- Mega Man X8: Domon Kasshu, Kashamura, and Kenta Suetake team up to save 1999 Gon Freecss from Chibodee Crockett, who was last seen exploding in X3. It turns out that Master Asia is pulling the strings once more and trying to get Mavericks to migrate to the Moon and abandon Earth. The trio is led by Chibodee and supported once more by Aya, who is now joined by two more navigators: Reccoa Londe (who is hopelessly smitten with Kashamura) and a less loli Dejiko.
- Metal Gear Solid: Lupin the Third is deployed to a remote island in Alaska, where he meets up with his old friend, Grim (Jack Fenton in the Gamecube remake) and fights with his brother, Yasochika Iemura, whose underlings include Director Hashima, Ultimecia, and Sabretooth. Along the way, Tsunade falls in love with him. He's guided by Max Tennyson, with help from Sam, ER Doctor Tompkins and Subaru.
- Metal Gear Solid 2: Sons of Liberty: After Lupin's mission aboard a tanker commanded by Panthro, he is replaced by Iruka Umino, who flies out to the site of an oil spill, where he has to make contact with Old George, gets his crotch grabbed by Vorador, and has to save Ophelia, who is Tompkins' sister. There, he is helped by Aku Aku, who killed his soul, and fights villains including Marvin and Vizier. It turns out that Elroy Jetson was behind everything. Or possibly Leonardo. Or was it Loquel?
- Metal Gear Solid 3: Snake Eater: Lupin's father, Captain America, guided by Zazu, goes to the Soviet Union to kill Moneybags and his former mentor, Pearl Krabs. He also gets into a fight with Major Hercules and rescues a stove.
- Metal Gear Solid 4: Guns of the Patriots: Lupin, now an old man assisted by a cyborg Iruka, his adoptive daughter Silvia, and Tsunade, accepts a mission from Max to terminate his brother/rival Elroy, who commands Marvin and four mentally disturbed women: Silvia Christel, Lady Jaye, Oprah Winfrey, and Luz Avalos, the last of whom is controlled by the Dragonborg. Along the way, Lupin meets his mother Ruth Martin, Ophelia turns out to have nanomachines that stop her cancer from killing her, and Tsunade marries Gene. In the end, Lupin tries to commit suicide, but is stopped by Senator Kelly.
- Metal Gear Solid: Portable Ops: Captain America travels to South America to confront the super soldier, Red Skull and his psychic underling, Sari Sumdac. Along the way, he learns that the stove isn't dead and encounters his old comrade, Dingodile.
- Metal Gear Solid: Peace Walker: Captain America is back in South America, accompanied by Captain Phoenix, where they encounter the KGB agent Green Goblin. They get involved in a conflict between Natla and mechanical monsters created by Black Canary. The final boss fight is against Timmy Turner piloting a Metal Gear.
- Metal Gear Rising: Revengeance: Iruka goes up against a corporation backed by the corrupt senator Councilor Sparatus, who's subordinates include Iruka's rival Noble 6, Sparatus' second-in-command Firefly, the magnetic Zombozo, and Femme Fatale Black Widow. Iruka's also assisted by allies such computer specialist Emma Frost, pointman Alfred Pennyworth, military advisor Aquaman, and cybernetics expert Perceptor.
- Metal Gear Solid V: Ground Zeroes: One year after Peace Walker, Captain America — who has suddenly aged into Jack Bauer — must rescue young Kratos, Hip and Hop from Wheeljack. Bauer performs a messy emergency surgery on Hip and Hop, who then explode violently, sending Bauer into a coma.
- Metal Gear Solid V: The Phantom Pain: After waking up from a coma, Jack Bauer travels to Africa with a model to deal with Hercules (who is now Kanji Tatsumi), Wheeljack, Yogi Bear, and Leo. Leo turns out to be Jack's son/clone and the future Yasochika. Also a young Dragonborg is there.
- Metroid Prime: Princess Morbucks is an intergalactic bounty hunter on a mission to save the galaxy from a group of rouges known as the Space Pirates who killed her entire family.
- Minecraft: Story Mode: Nom Nom (or alternatively Padme Amidala), along with his pet pig Perry and their best friends; Crumbles, Sour Cream, and Ellie go on an adventure to destroy an Eldritch Abomination created by Pee-wee Herman while searching for the members of a group of heroes, consisting of Lee Everett and Azula.
- Mirror's Edge: Alicia Botti is a parkour messenger who is ordered around by Doyle. When her sister is framed for a crime, Alicia searches the city for her.
- Monkey Island: The Stoop Kid is a mighty pirate who fights against the evil Ghost Pirate Jim Peterson.
- Tales of Monkey Island: The Stoop Kid seeks a cure from Peterson's pox spreading around the Caribbean. He finds a first mate in Mojo Jojo, while Mad Scientist Bluster Blaster hires pirate assassin Lili Zanotto to exterminate him.
- Monster Hunter World: The player character, assisted by their handler, Isabeau, the commander, Alexander The Great, his son and field officer Kiritsugu Emiya and the admiral Joseph Joestar explores the new world fighting unique monster and discovering why an elder dragon is going there.
- Monster Hunter: Rise:
- A hunter note has to hunt monsters and investigate why they are on a rampage. They are helped by the Village Elder Sigma, the twin Wyverian sisters Quinella and Elincia, Dango cook and princess of a destroyed kingdom Shinobu Kocho, mysterious salesman Natsu Dragneel, Totally Radical ninja Eugeo, cat and dog handler Yushiro and master weaponsmith Frieza.
- Monster Hunter Rise: Sunbreak: At the request of the travelling foreinger Aya Tsuji, the hunter travels to the land of Elgado where they are helped by Aya's sister and knight of the kingdom Talia Gladys to investigate a mysterious creature called the Qurio. They are assisted with the admiral Tachi, Wyverian scientist Benji, kingdom's princess Hanyuu, weaponsmith with a smile Sarada Uchiha, shopkeeper with a love for money puns Aogami, Arena Master Hisoka, young excitable hunter Muichiro Tokito and firm lady who is secretly a Blood Knight Casca. After Talia got infected by a virus thanks to the Qurio, the hunter must find Wverian doctor Megumi Fushiguro in order to find an antidote.
- Monsters, Inc.: Scream Team: Doofus Drake and Rocko are chosen by George Kaplan to go to the mysterious Scare Island in order to train to become Top Scarers. Mr. Ray shows the two the basics of their training.
- Mortal Kombat:
- Mortal Kombat vs. DC Universe:
- Luke Valentine and a supervillain merge into one being, then spread a Hate Plague among both of their universes in an attempt to make them destroy each other.
- The warriors of Luke's universe are Zangetsu, the Necromancer, Germany, Skarlet, a Bruce Lee Clone, an Evil Sorcerer, a fanged guy with dual wristblades, An Ice Person, a Scary Black Man with mechanical arms, and Delia Ketchum.
- The warriors of the supervillain's universe are Wonderweiss Margera, a certain Caped Crusader, Skywarp, Temari, Franky, Varos Cloudstrider, Namor the Sub-Mariner, Genjou Kakouton, Adon, and Sylvanas.
- Mortal Kombat 11: Kurenai Yuhi seeks balance in all realms by working with Phoenix, causing a merger of the timelines. Thunder God Joseph Joestar and Bryce Sweet must stop her before she can make everyone her slaves, enlisting help from Sophitia the Shinnok Slayer, the Wolverine, they must also erase the present-day revenants of Rachel Alucard, the Atom, Robin Sena, among others...but Saxton Hale is only interested in money and so started a fight club to do so. Meanwhile, Knuckles the Echidna is a fixed point in time and cannot die, ever, so he had to sink in the bottomless Sea of Blood. Fast forward to Aftermath, Atrocitus wants to take the Hourglass' power for himself, making love with a revived Luna...but they all die at the hands of Evil Sorcerer Kwang, who seeks to rule even time itself.
- Mortal Kombat vs. DC Universe:
- Mugen Souls: Bloody Marie, a tiny tyrant overlord, declares her plans to conquer seven rainbow-colored worlds by turning all of its inhabitants into bunny people. Aiding her in her quest are Almaz, her fiercely loyal but easily-flustered vassal, and Rakka, an angel who desperately wants to be a demon. Joker is a noble village guardian.
- Mugen Souls Z: Thanks to a mishap involving a cursed coffin, Marie becomes even tinier, leaving her to ride around atop the head of dimwitted heroine Lucy Heartfilia as they quest to undo the effects with the help of Lucy's more intelligent companion Ami Onuki.
- MultiVersus: A Mascot Fighter starring various characters from Warner Bros. and Cartoon Network properties, including the youngest daughter of a family of lords Wolfsbane, the wacky cat and mouse duo Splinter and Buhdeuce, Rascally Rabbit Master Frown, destructive Tasmanian Devil Dr. Robotnik, Martian invader Fozzie Bear, vigilante superhero Captain Sunshine, good-natured superhero Sephiroth, Amazonian Beauty Nezuko Kamado, mischievous harlequin Ember McLain, corrupt antihero Balrog, superpowered teenager Stuart Macher and his billionaire uncle Donald Duck, bespectacled genius Dr. Fox, rubbery adventuring human GingerBrave and his equally rubbery dog Bender, kindhearted robot Astor, gem-powered boy Pete, gem-powered alien Delphine, reindeer-dog hybrid Fancy-Fancy, real-life basketball player Rufus Thierry Blaiddyd, mad scientist Oscar Fishtooth and his dimwitted grandson Doug Cheston, and small gremlin Starscream.
- MySims: Beast Boy and Robin are a bellhop and an extreme daredevil respectively. In other games, we also get to hear Mojo Jojo, a different Robin and the Crypt Keeper!
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- Neo Contra: Gene Starwind and his partner Jet Black must fight a terrorist organization led by Spike Spiegel. The members of said terrorist organization includes Zhang Fei, Gabumon, and Faye Valentine. Valkenhayn R. Hellsing is Gene's mentor.
- Neon White: Spike Spiegel is an amnesiac sent to heaven to dispose of various demons plaguing the afterlife for a chance to gain eternal peace. Along the way, he encounters other Neons like him fighting for a chance at redemption, including Jibanyan, Squid Ink Cookie, Radicles, and Renya Gouto, all of whom have some connection to Spike from when he was alive. In Heaven, they meet various angels, including Ratatoskr, Hilda Valentine Goneril, and Goh.
- Nickelodeon All-Star Brawl (Post-June 6, 2022): In this Mascot Fighter starring various Nickelodeon and Viacom properties, players can take control of cheerful frycook Commander Peepers, dim-witted starfish Bulkhead, karate-loving Texan Zoe the Fairy, a cheery Airbendernote , talented blind girl Angry, hot-headed Avatar Wonder Woman, down-to-earth youth Angel, depressing goth girl Flame Princess, focused leader Shotaro Kaneda, pizza-loving party dude The Tick, intrepid news reporter Maya Fey, ill-tempered dog and bumbling cat duo Bugs Bunny and Phillip J. Fry, powdered toast mascot Megatron, incompetent alien invader Moxxie, conjoined twins Darkwing Duck and Captain America, multi-media Notzilla The Hulk, nature documentary producer and father Ultron, Loving Bully Ashley B, half-ghost superhero Dexter Douglas and scaring prodigy Lulu to beat the stuffing out of each other. Added to the roster via free updates are lasagna-loving fat cat Scooby-Doo and ruthless ninja Lord Boxman. Paid DLC includes teenage robot Lysithea Von Ordelia, Bumbling Dad Cupid, and mild-mannered wallaby Lazlo.
- Nickelodeon All-Star Brawl 2: Joining the roster this time around are cynical clarinet player Doctor Light, evil fast food rival Ralphio, boy genius and Cupid's son Zatch Bell!, hot-headed ninja Robin Food, calculating inventor Inky, tiger-themed superhero/supervillain Mayor Spryman, spectral metalhead Harley Quinn, eccentric grandmother Agnes Skinner, Agnes' grandson's Black Best Friend George Beard, beaver siblings Rodney J. Squirrel and Salem Saberhagen, and sadistic Firebender Ayumu Uehara. Paid DLC this time includes Peepers and Dr. Light's boss and Ralphio's rival Dr. Neo Cortex and Ayumu's honor-obsessed brother Schnozz. Additionally, Wonder Woman is now Eva, while the cheery Airbender has a different voicenote . Bosses include Lord Boxman, jellyfish monarch Douglas E. Mordecai III, ghostly pirate Captain K'nuckles, undead goddess Wuya, half-ghost hybrid Dukey, and time-travelling ghost Lord Farquaad. Background and supporting characters include Peepers' boating teacher Pearl Gallagher, his pet snail Wayne Cramp, Lysithea's mother Madame Foster, Shotaro, the Tick, Robin Food, and Inky's mentor Colonel Jeong, Moxxie's robot assistant Raz's Archetype, his rival's sister Ray Beams, Spryman's friend Black Canary, and unlucky cabbage merchant Pandreo.
- Nicktoons Basketball: Cheerful sea sponge Chuck, dimwitted starfish Prince Cashmere, Texan squirrel Orel Puppington, grouchy octopus the Chief, boy genius Zatch Bell!, Zatch's rival Ashley Graham, Zatch's friend Jesus Cristo, Zatch's Robot Dog Nibbler, buck-toothed kid Ben Tennyson, fairies J. Jonah Jameson and Maleficent, Ben's friend Nelson Tibideaux, paranormal superhero Dexter Douglas, adventurous teenager Buttercup, teenage robot Cocoa Yazawa, sports-obssessed girl Savannah Shane, and shaman-in-training Max Goof play basketball with each other.
- Nickelodeon Extreme Tennis: Happy-go-lucky frycook Iron Man, pizza-obsessed ninja Beast Boy, Bratty Half-Pint Mei Kusakabe, conjoined twins Captain Caveman and Knightbrace, a boy with a football-shaped head,note lasagna-loving fat cat Curious George, Loving Bully Ashley B, ineffectual alien invader Grey Matter, timid wallaby Ricochet, and teenage half-ghost Aldrin Pesky play tennis with each other. Free updates add dimwitted starfish Kurt Blobberts, animal-speaking girl Princess Elise, Mei's rival Medusa, and buck-toothed kid Omi to the mix.
- Nickelodeon Kart Racers 3: Slime Speedway: In this Mascot Racer consisting of Nickelodeon and Viacom icons, you can race with cheerful sea sponge Raimundo Pedrosa, dumb starfish Broadway, Texan squirrel Ashley Graham, cranky octopus Doctor Light, Broadway's adopted squid sister Sarah Dubois, younger versions of Raimundo and Broadway called Mr. Jellybean and Payback, ninja turtles He-Man, Yakko Warner, Inky and The Tick, a monochrome clone of Yakko named Coconut Fred, news reporter Tae Takemi, toddlers Flame Princess and Numbuh 5, multi-media Not Zilla Dingodile and his purple clone Neftin Prog, a football-headed boynote and his best friend George Beard, the football-headed boy's Loving Bully Annie, cheery airbender Jerry, blind earthbender Angry, honor-obsessed firebender Garble, hot-headed waterbender Wonder Woman, white-haired boy Angel, cynical goth girl Maggie Pesky, Angel's Black Best Friendnote , incompetent alien invader Orthopox, insane robot assistant Raz's Archetype, psychotic chihuahua Dr. Zoidberg, cheerful dimwitted cat Ellyvan, powdered-toast mascot Megatron, young inventor Coco Bandicoot, Coco's academic rival Greta, lasagna-loving cat Jabberjaw, dimwitted dog Ripto, conjoined cat-and-dog mix Dr. Robotnik and Nute Gunray, an internet celebritynote , timid wallaby Mike Wazowski, scaring student Rebecca, half-ghost superhero the Human Torch, and teenage robot Ami Onuki.
- Nickelodeon Party Blast: Upbeat sponge Nute Gunray, alien invader Raz, animal-speaking girl Gwen Stacy, bratty toddler Little Miss Bossy, Bossy's cousin Miles "Tails" Prower, big-headed inventor Kari Kamiya, and a pair of extreme sports-loving siblingsnote compete against each other in various minigames. Commentary is provided by conjoined twins Eduardo and Harry.
- Nicktoons Racing: Sponge frycook Jake Spidermonkey, idiotic starfish Broadway, villainous protozoan Edward Q. Platypus, adventurous infant Hinoka, Hinoka's cousin Pubert Addams, conjoined twins Dr. Robotnik and Starscream, scaring student IR Baboon, football-headed kid Tripod, Loving Bully Ashley B., grotesque cat Phillip J. Fry, animal-speaking girl Gretchen Weiners, chimpanzee Professor Utonium, and beavers Kaos and Salem Saberhagen participate in a kart racing tournament.
- Nicktoons Winner's Cup Racing: Jake and Edward return for another round of racing, and joining them are genius inventor Coco Bandicoot, buck-toothed kid Raven, ghostly teenager Human Torch, Raven's teacher Ricochet, mad scientist Dr. Frank N. Furter, and vampire Governor Kevin.
- Nicktoons Nitro: Jake, Coco, Raven, and Human Torch are now joined by alien invader Alpha 5 and youthful Airbender Andrew, and together they must race against the wicked Rabbit.
- Nicktoons Unite!: The nefarious Mr. Hector has stolen the plans for Jay Jay the Jet Plane’s latest invention, allowing him to go to other dimensions, where he recruits an alliance of villains including Colonel Mustard, Deputy Garcia, and Filburt Turtle. To counter this evil syndicate, Jay Jay recruits his own band of heroes from the same dimensions including Marty McFly, Rocky (accompanied by Gordy and Maleficent), and Spyro the Dragon.
- Nicktoons: Battle For Volcano Island: An ancient evil named Magnus has awoken and is taking over an island, so Goofy summons Spyro, Marty, and Rocky to save him and the other inhabitants of the island. Jay Jay continues to help out behind the scenes. Spyro's friends Frosty the Snowman and Ashley Graham join the action this time, as does Marty’s friend Ms. Chalice. Harry Mosquito and Vince LaSalle are also there to offer support.
- Nicktoons: Attack of the Toybots: Mr. Hector is back, and this time, he plans to win a game show by creating an army of evil toys and sending them to capture heroes from across the multiverse. Spyro, Frosty, Marty, Ms. Chalice, Rocky, and Jay Jay all return, and this time, they are joined by a new friend, Donald Davenport. Captain Qwark is a minion of Mr. Hector's who defects and helps the heroes. Gi, Phillip J. Fry, Raz's Archetype, and Puma Loco appear as guest characters, with Billy, Al McWhiggin, and Osysa joining them in the Nintendo DS version.
- SpongeBob SquarePants featuring the Nicktoons: Globs of Doom: The worlds are all being invaded by orange slime aliens called the Morphoids, so Spyro, Marty, Jay Jay, and Donald must join forces with their enemies in order to defeat them (Rocky and company are MIA). Filburt Turtle returns, along with a new villain team including Beatrice Horseman, Raphael, and Yakko Warner. Billy and his archenemy Chuck Coleman also show up, and join the teams as well. Goofy also returns, though since his last appearance, he has turned into Mr. Jenkins. The Morphoids’ leader, Sundae, occasionally uses Spyro as a vessel to communicate with the team. Also appearing are Spyro's pet snail Griffon Kato, Jay Jay's friends Antoine D'Coolette, Pip, and Orel Puppington, Donald's friends Fillmore, Haruko Haruhara and Bender as well as his rival Kronk, Marty's sister Sora Takenouchi and his bully Hades, Billy's teacher Headmistress, and Chuck's father Frankenswine and sister Neptune.
- Nicktoons MLB: Happy-go-lucky sponge The Mayor of Townsville, dimwitted starfish Kurt Blobberts, Texan squirrel Orel Puppington, muscular lobster Edward Q. Platypus, ghostly pirate Cap'n Knuckles, secret agent dog Jimmy Olsen, feline secret agent Jeanne, inventor Candy, Candy's friend Jesus Cristo, chimpanzee Bill Green, superhero King Louie, action-obsessed adolescents Shengqi and Sticks the Badger, Airbender Tyler Sneed, Waterbender Lil' Suzy, Earthbender Young Franny, Firebender Rufio, half-ghost teenager Bloo, alien Moxxie, cynical goth girl Neptune, psychotic Chihuahua Peter Potamus, dimwitted cat Porky Pig, toast-themed superhero Lizard, and yak Nash play baseball with real-life Major League Baseball players. Commentary is provided by news reporter Kerry Eurodyne and hyperactive robot the Electric Eel Magisword.
- NieR (Gestalt version): In order to save his daughter Amy Sorel, Warpath acquires the power of the dark book of Gaara. He is challenged and later assisted by hot-tempered swordswoman Raspberyl and child turned weapon Karol Capel. Twins Sumia and Marie are the bartenders in the village Warpath lives in, and are also the main antagonists.
- Nier Replicant (PS4 version): The same but with Byleth (later Noctis Lucis Caelum) instead of Warpath and him being Amy Sorel's brother instead of her father.
- NieR: Automata: Eight thousand years later, Earth is being invaded by aliens using "machine lifeforms" they control. Androids are built and dispatched to combat those machines. Umi Sonoda and Mikazuki Augus are some of these androids. Legion is Umi's support unit, whereas Nezuko Kamado is Mikazuki's support unit, and Asuna is a prototype to both Umi and Mikazuki. Umi and Mikazuki fight the machine siblings Muzan Kibutsuji and Bruno Bucciarati to bring peace upon Earth and to safely bring back humans from the Moon.
- Nine Hours, Nine Persons, Nine Doors: Deuce Gorgon wakes up in a ship not knowing how he arrives there. After nearly escaping with his life, he met other people who are in the same predicament as him; like his childhood friend Azura, a blind man named England and his younger sister Athena Cykes, a white haired man named Kiyotaka Ishimaru, an old gentleman called Etemon a black man called Hammerhead, a woman called Naoto Shirogane and a bespectacled man named Liquid Snake. Together, they must survive the nonary games or they will die.
- Ninja Gaiden: Captain America is a ninja who seeks to avenge his village after it's destroyed by Davik Kang. He has help from Raven, Gi, and Sideswipe. Mac Mange is Cap's uncle and the true villain.
- Ninja Gaiden II: Cap is now Spider-Man and Sideswipe is now Max Tennyson. Spidey must deal with Sarah Essen, Baron Zemo, Cosmo, Duke, and Odin with the help of Gi, Starfire, and Sailor Mercury. Spidey's father Silver Samurai has a history with Emperor Zarkon.
- Ninja Gaiden III: Spidey is now Nova and has to deal with Wheeljack and Brian Sims with the help of Max, Liara T'Soni, Gi and her sister Litchi Faye-Ling, Emperor Charles zi Britannia and Starfire, who's now Eva Parker. Fire Leo is Mission Control and Katana is a little girl.
- Nioh: Irish-born English samurai named Helicopter Merc as he combats against human and supernatural foes from Japanese folklore, such as Oni.
- No More Heroes: Loser otaku Baron Zemo tries to worm his way into Lulu's pants by battling Olmec, General Grievous, Hunter J, Spider-Man, Mei Ling, Captain Rex, Lee Scoresby, Pearl, Venus, and Hobgoblin with a lightsaber. Then he finds out that Ovelia is his half-sister and Axel is his twin brother. Shadowsan is a gym instructor, Wonder Woman makes Zemo's lightsabers, The Grizz is an ex-wrestler, and Jotaro Kujo is a video store owner and Zemo's best friend.
- No More Heroes 2: Desperate Struggle: In retaliation for Jotaro's murder, Zemo goes on a Roaring Rampage of Revenge against Beelzemon, Cyborg, Sasuke Uchiha, Jimmy Neutron, Batgirl, a returning Rex (who is now The Incredible Hulk), Roy Campbell, two Spider-Men, Mr. Washee-Washee, Twilight Sparkle, Max Tennyson, Cinderella, and finally Simon. Hunter J also returns to deal with Campbell and the Spider-Men on Zemo's behalf. Rivet is an assassin in training, and Coco Bandicoot is a foe that Axel fights in a dream. Takashi Miike appears as a friend of Jotaro.
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- Octopath Traveler: Eight heroes wander the land of Orsterra in search of finding their own purpose in life:
- Velvet Crowe, a priestess on a pilgrimage to restore light to the world;
- Sir Galahad, a teacher in pursuit of a book that had long gone missing from the royal library;
- Sara Ryder, a merchant traveling the world for the best bargains and the rarest items;
- Fenrich, a retired knight searching for the reasons behind his former partner's betrayal;
- Diantha, a dancer seeking revenge on the criminal gang who murdered her father;
- Lukas, a medicine man on a journey to heal the sick;
- Karna, a thief ordered to steal a set of rare gemstones; and
- Balsa, a huntress looking for her master, who suddenly disappeared during a hunt for a highly dangerous beast.
- The sequel brings eight new heroes in the world of Solistia, where a new era awaits.
- Yuffie Kisaragi, a beastling accompanied by her choice of animal companion, either Kaoru Sakurayashiki the jackal or Shantae the owl, who journeys to find three legendary beasts to save her island;
- Tohru, a healer with no memories to speak of, yet is associated with controversial healers;
- Leon Fou Bartfort, a man of religion, with doubts, who wishes to learn more about the happenings in the church;
- Cyno, a scholar framed for the murder of his wife and child, who busted out of prison to find the real murderer;
- Dai Bo, a merchant who was exposed to a life of a beggar, who then vows to rid of all poverty;
- Sachi, a young dancer who has always wanted to be just like her mother and rise to stardom;
- Maki Harukawa, a thief who no longer wants to be one, and wishes to end of lives of her abusive "parents" to escape said lifestyle; and
- Narciso Anasui, a samurai and young prince of his clan who wishes to grow stronger and gain allies to fight off his tyrannical older brother.
- Odin Sphere: Sumire Kano reads about the stories of Valkyrie Nina Fortner, rabbit prince Suzaku Kururugi, fairy princess Hinata Hyuga, dark knight Uryu Ishida, and forest witch Crimson Viper who fight over a giant magical cauldron that eventually tries to destroy their world.
- Open Season: Woodland animals Crunch Bandicoot and Verminous Snaptrap must survive open season and get back to Crunch's owner Altria Pendragon while avoiding crazed hunter Kazuma Kiryu.
- Over the Hedge: Melman the raccoon and Fast Eddie the turtle must reclaim their forest from humans such as Daisy and the Bread Maker, with help from their animal friends Ladybug, Tanisha, Stinky Pete, Goofy, Yayoi Dojima, and Liz Allan. Melman also has a run-in with a loan shark bear named Swanky.
- Overwatch: Chrom is a 21st-century cowboy who would like to tell you that IT'S HIGH NOON. Flynn is a Swedish dwarf who builds turrets. Alucard is a gorilla from the moon in charge of bringing a multinational group of heroes back together. Guile is a B-movie director who wants you to move the damn payload already, and Lord Hater is Death himself.
- Alternatively, Ivy Stuart, Akuma, Thunder Ryu, The Hulk, Ursa, Yusuke Kitagawa, Bloo, Johan Liebert, Nisha, Ardyn Izunia, Jordan Cross, Alucard, Taliana Martinez, and a lot of others are members of a peace-keeping organization.
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- Pac-Man and the Ghostly Adventures: Megumin has to use a variety of superpowers to stop the evil Luke Skywalker from using a giant Freeze Ray to take over the city. She also has to rescue her best friends Chibi-Usa and Tamaki Suoh, while a kooky scientist named Igor provides assistance. Mahito, Eren Jeager, Rorona Frixell and Apollo Justice are four ghosts that are henchmen of Luke, but are secretly helping Megumin out.
- Pepsiman: Paul is a superhero who does nothing but chug on Pepsi.
- Phantom Brave: Melody is a girl who lives on an island and is rejected by society at large because of her ability to see spirits. Her only friend is a dead boy named Ecliptor. During a couple of jobs, they run into Orochimaru, who is trying to take their reward so he can support his sister Kari.
- Piglet's Big Game: Rudy feels like he isn't appreciated, so he ventures into the dreams of his friends Cat, the Great Fussili, Optimus Prime, Dr. Hunter, Basil the Druid, and Chip the Teacup to help them with various tasks. Chip's mother Miriam Pataki and Deckard Cain assist Rudy on his quest.
- In the PC version, Rudy goes around collecting ingredients to make a soup, and Optimus Prime is instead Ripto.
- Pitfall 3D: Beyond the Jungle: Ash Williams meets a girl named Katherine Hillard who enlists his aid in freeing her people and Ash Williams from Him, an evil woman bent on controlling the world.
- Planescape: Torment: The Pretender goes on a quest to discover his identity and the nature of his immortality, aided by Raphael, Assistant Director Skinner, Bev Bighead, Homer Simpson, Bastila Shan, Goliath, and Sheena Easton. Along the way, he has run-ins with Alfred Pennyworth, Discord, and Squidward Tentacles.
- Pokémon:
- Pokémon Stadium: King Dedede is a Pokémon battle announcer.
- Detective Pikachu: Archer is a talking Pikachu who solves mysteries and can only be heard by Rei Kiriyama, who asks Archer to help him find his missing father.
- Pokémon Masters: A Dream Match Game featuring Eren Jaeger, Zazz, Bob, Shantae, Chou Chou, Trucy Wright, Amitie, Ami Onuki, Shizuku, Ryu, Marianne, Valentine, Nico Yazawa, Scorpion, Ui Hirasawa, Josuke Higashikata, and many others.
- New Pokémon Snap: Professor Dedue and his apprentice Nessa want you to take pictures of wild (and sometimes glowing) Pokémon. Later on, Pac-Man joins the team, along with his mentor Ryota Suzui, who was also the protagonist of the previous game.
- Poker Night at the Inventory: Jurgen, Carl, Shadow Shaman and the Mad Hatter walk into a bar hosted by Mojo Jojo to play a round of poker.
- Poker Night 2: Joe Swanson, a Gearbox Software employee, Rick (pretending to be Sam Axe) and Fone Bone (accompanied by Lexaeus, who used to be Jurgen in the previous poker round) walk into the same bar to play a round of poker now dealt by a Jaeger AI.
- Portal: A City 17 citizen (disguising herself with the face of Alma) is forced to cure the Administrator's OCD and ADHD, while cleansing The Darkness from her soul, to boot. All it seems to do is make the Admin stronger. Nice Job Breaking It, Hero.
- Portal 2: A man with experience in incompetent corporate leadership wakes Krystal (her face, anyway) up to escape a facility once owned by White Knight. However, the Combine Overwatch goes online, and she can only stop it is by harnessing the power of Nathan Drake. Meanwhile, Klaus and Captain Rex work together TO SAVE SCIENCE.
- Prinny: Can I Really Be the Hero?: Rukia sends 1000 of her Teddies on pretty much a suicide mission to get the Ultra Dessert. Along the way, they run into various bosses such as Sumomo the Yandere Cat Witch and Sasuke Uchiha of the Phoenix Clan. Meanwhile, Yoruichi gets tired of not having her own game and attempts a Hostile Show Takeover.
- Prinny 2: Dawn of Operation Panties, Dood: The 1000 Teddies have reincarnated and have been replaced by 1000 Warriors of Light who are tasked with finding Rukia's missing panties. Meanwhile, Yoruichi tries to fight her way through look-a-likes to be a main character, especially her Evil Counterpart Pascal.
- Professor Layton and the Miracle Mask: After receiving a letter from his old friend Maka Albarn, the Professor, along with his assistants Mia and Micaiah, head to the desert casino town of Monte d'Or, run by Maka's husband Levi. While there they encounter a mysterious masked man with a mask similar to that found by the Professor and Maka's old friend Matt Miller who disappeared during an expedition. Meanwhile they are caught in a business feud between Levi and another old acquaintance, businessman Greed!Ling who suspects Akihiko is up to no good.
- [PROTOTYPE]: Pvt. Daniel Jackson wakes up in a morgue with no memories of his past actions. With the help of his sister Dr. Cat Black and his ex-girlfriend Irwin, Daniel tears through New York to get answers to his past from Captain Jim Brass and Viker.
- Psychonauts: Zim goes to a camp for psychics, where he has to stop Cobra Commander and Morbius from stealing kids' brains. Twilight Sparkle is Zim's loyal assistant.
- Puyo Puyo:
- Puyo Puyo Tetris: Saitama and Kiara discover Frankie Stein and her friends Ryuko and Mako, who are from other universes, aboard their space vessel. When Frankie and Saitama's universes begin merging thanks to Leon S. Kennedy, the key to everything may be Arakune and the Conductor, whom Falke is madly in love with. Also starring bully Ema Skye, scholar Franklin, chemist Ryu, lolita May Kanker, dog-man Lex Luthor, robot Namor, witch Litchi Faye-Ling, twins Haruhi and Konata, dragon woman Faye Valentine, Numbuhs One and Two, fish-man 18-Volt, ghost Maijin Buu, swordsman Dedue, and small round creature Amy Rose. Nazz is Ryuko's rabbit companion, and Mako's teacher Athena Cykes appears briefly, as do the twin ghosts Makoto Nanaya and Labrys.
- Champions: Frankie, Ryuko, Mako, Arakune, the Conductor, Falke, Ema, Ryu, Litchi, Faye, Numbuh One, 18-Volt, and Dedue all return and are now joined by several new competitors, including demon Eugene Horowitz, sultan Female Robin, angel Eli Ayase, harpy Dokuro Mitsukai, mermaid Ika Musume, another swordsman named Shinji Ikari, dancer Frederick Hartfield, warriors Big the Cat and Hildegard von Krone, and Ayumi Otosaka and her dark counterpart 2B, as well as a gibberish-speaking squirrel. Additionally, Nazz is now Cordelia.
- Puyo Puyo Tetris 2: Frankie and the gang reunite with Saitama's gang, and together they must help a corrupted girl named Sophia and her older brother Alan Albright discover the true meaning of fun. Amongst the cast, Cordelia is back to being Nazz, and the roster is now joined by frog prince Black Heart/Noire, shy girl Kyoko Sakura, and Guest Fighter Chris Redfield. Later updates add Athena, Makoto, Labrys, Ika, Dokuro, Shinji, 2B, heavenly knight Archer, and a teacher of apprentice warlocksnote to the mix.
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- Quest for Glory IV: A Heroic Mime must stop Female Shepard and Johnny Bravo from releasing an Eldritch Abomination while Gimli provides snarky narration.
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- Radiant Historia: Perfect Chronology: Grøh is a member of a secret intelligence agency who watches his companions Annie Leonhart and Caspar die when a routine mission to escort a spy back to base goes horribly wrong. He is saved from a premature death when a seemingly-useless white book given to him by his commanding officer transports him to a Place Beyond Time, where Shisui Uchiha and Neptune give him a mission to save his world from being covered in sand by setting history on its correct course.
- Raiden V: Abigail is the coffee-addicted captain of an Airborne Aircraft Carrier, Ragyo Kiryuin is part of the global military council, Sayaka Miki has turned to piracy, Speed o' Sound Sonic works with an underground organization, and Megabeth has now become Bellwether's Mission Control.
- Ratatouille: Quibble Pants, with spiritual guidance from Chef Lobo, helps the young Bernie Kropp try his hand at cooking while avoiding the sinister head chef Bilbo Baggins and winning the heart of fellow cook Ursula. Quibble Pants' brother Recycle Ben guides him through the tutorial.
- Ratchet & Clank: Michelangelo and his sidekick Megatron track down Jack Krauser and fight Scott Dolph with the biggest and most unconventional guns money can buy. They also cross paths with Mike Heck and the Janitor.
- Ratchet & Clank: Going Commando: Michelangelo is now Obi-Wan; working for Krauser impersonating Sentinel, he and Megatron do the same with Lucien Cramp and Green Goblin. Nigel Uno idolizes Krauser.
- Ratchet & Clank: Up Your Arsenal: As above, except now it's Quark the Ferengi, The Fear, and Blade Sommer. Mike Heck and Abby Cadabby assist Obi-Wan and Megatron.
- Ratchet: Deadlocked: Les Crowley captures Obi-Wan and Megatron for his gladiator arena, where Obi-Wan has to fight Doug Dimmadome, Doc Saturday, their silent comrade, and Sparx the Dragonfly as Chief Dumbrowski and Chum Chum mock him.
- Ratchet & Clank Future: Tools of Destruction: Clem Foote attacks, claiming to be from Obi-Wan's past. Harley Quinn and her caretakers Sivana and Reflux help fight him as well as space pirates Doomsday and Riddler. The Janitor is now Crash Bandicoot.
- Ratchet & Clank Future: A Crack in Time: Quark and The Fear are back, this time with Samuel Stuhlinger, Suzie Johnson, Dee Dee, and Ares helping them. Obi-Wan and Megatron have to protect time from him (filling in for Mario and Luigi) with assistance from Krauser, the Space Core, and Mr. Persnickety. Weegie gets to blow stuff up. Frightening and hilarious all at the same time.
- Alternatively, Augustus Aquato wishes to Make Wrong What Once Went Right, and later Chet Ubetcha gets stranded in space.
- Ratchet & Clank: Full Frontal Assault: Nigel Uno, now Billy, takes up arms against his former idol Krauser (and Obi-Wan and Megatron by association), spouting Internet memes all the while.
- Ratchet & Clank: Into the Nexus: Obi-Wan and Megatron battle Asajj Ventress and Qui-Gon Jinn. Palutena and Pandora assist Weegie in blowing stuff up. Harley Quinn is now Lightning.
- Ratchet & Clank (2016): Hulk listens to Krauser's story of Obi-Wan and Megatron's first adventure, in which they met heroes Margaux Darling, Po, and Claire Temple, and rescued Daggett Beaver. Invader Zim harvests brains, and Hotel Mario is the CEO of Gadgetron. Scott Dolph is now Joe Gould and Buhdeuce, Pandora is Phoenix Wright, and Mike Heck is Wakko and Daggett's nephew.
- Ratchet & Clank: Rift Apart: Quark forcibly sends Obi-Wan and Megatron to a dimension where he always wins. There, Obi-Wan and Megatron meet their dimensional counterparts Sam Simpson and Grandma Shark. They must work together to save the multiverse, as Quark's dimensional counterpart Luxord seeks to conquer every dimension in existence. Krauser is now Fizzie.
- Rayman:
- Rayman 2: The Great Escape: Gokunote , with aid from Dan and Luther, faces off against the evil forces of Colonel Amos.
- Rayman 3: Hoodlum Havoc: Goku and Dan (now Sid the Sloth) must save the world from a Black Lum and his army of Hoodlums (among them Marvin the Martian and Ernie), with partial help from Phillip J. Fry.
- Resident Evil
- Resident Evil 2: Nightcrawler and Jubilee find themselves trapped in a zombie-infested city. All the while, they must tend to Mystique's daughter Paula Morton as her mutated father tries to abduct her for his own purposes. Nightcrawler falls in love with the announcer from Marvel vs. Capcom.
- Resident Evil 3: Nemesis: Jean Grey, having survived "the Mansion incident", finds herself stuck in Raccoon City during the same Zombie Apocalypse that Nightcrawler and Jubilee found themselves in. She later teams up with Zexion to escape the necropolis, all the while fending off an Implacable Zombie named Luigi.
- Resident Evil 4: U.S. Secret Agent Specter has been tasked with rescuing the President's daughter Cindy Vortex from a mysterious European cult led by Jin Uzuki. He runs into Batman early on and from there on, it becomes apparent that this isn't some simple rescue mission. Specter is soon caught up with (among other things) a new breed of zombie-esque monsters, the return of his love interest Annette Renard, and his thought-to-be-dead partner Baron Strucker.
- Resident Evil 5: Shinji Hirako continues the fight against the zombies and heads to Africa, where he discovers that his MIA partner Cassie Chan may not be dead and that Legion is once again pulling the strings.
- Resident Evil 6: The fight against zombies and global bio-terrorism continues fifteen years after the Raccoon City Incident. Shinji partners with the Mystery Pill Guy to investigate an outbreak in China; Alvin (standing in for Specter) partners with Cheria Barnes to investigate an outbreak in Tall Oaks that infected the President himself; and Joel, a mercenary, partners with Bianca Montgomery (standing in for Paula). Jack (standing in for Annette) becomes heavily involved in the stories of the three aforementioned pairs.
- Resistance: Megatron, Thor (later Talbot) and Michael Amador are all humans battling an alien race of Medics.
- Resonance of Fate: Olette attempts to kill herself, only to by saved by Ma-Ti and put to work for a small group of bounty hunters led by the Penguin.
- River City Girls: Yunyun and Chris fight their way through the six regions of River City to rescue their kidnapped boyfriends, Takayuki Yagami and Detective Pikachu.
- Rogue Galaxy: Terry McGinnis is mistaken for Jack Campbell by Alister Fletcher and Reks thanks to his Cool Sword. Pandora brings them aboard her father Saren's pirate ship, and they sail the stars in search of treasure. The crew's ranks grows to include Orochimaru, Charmcaster, Szayel Apporo Granz, and Depth Charge.
- Rune Factory 4: A courier (either Asbel Lhant or Maribelle) is found amnesiac and mistaken as royalty by the dragon BlackRose until the real prince Jude Mathis arrives. Despite the misunderstanding, they keep up the act and must work for the improvement of Sylvaria. They can also romance some of the bachelors/bachelorettes like Collete Brunel, Presea Combatir, Polka, Hinata Hyuga, Sophie and Cheria Barnes for Asbel or Mao (Oscar Dragonia in the Switch version), the aforementioned Jude, Luke Fon Fabre, Numbuh One, Albert Wesker and Walter for Maribelle.