Batman is a standout example, both in terms of memorable villains and in terms of sheer size. Many individual members of the Bat-Family all have their own rogues galleries, too. Combine them all and you have one of the biggest rogues gallery in comics history, with new members being added all the time:
The most famous examples include The Scarecrownote a psychologist dressed in a scarecrow costume who is obsessed with fear, Two-Facenote an attorney who became obsessed with duality after half his body was disfigured, Poison Ivynote a woman capable of controlling plants and an eco-terrorist, The Penguinnote a scion of a wealthy family who was born heavily disfigured; now a crime lord in Gotham City, The Riddlernote a criminal mastermind obsessed with proving his own genius by leaving difficult clues behind, Catwomannote a cat burglar who has an on-off relationship with Batman, Mr. Freeze,note a cryogenicist trapped in a cooling suit; he is seeking money to revive his frozen wife, and The Jokernote an incredibly deranged man who looks like a clown obsessed with Batman himself. Lesser known, but still highly important villains, include Hugo Strangenote a scientist and psychologist also obsessed with Batman, being one of the few to have been able to deduce his true identity, Hushnote scion of a wealthy Gotham family who wants revenge on the Wayne family, Harley Quinnnote a former psychiatrist of Arkham Asylum who became infatuated with The Joker, Clayfacenote a series of characters who all have clay-like bodies that allow them to take on the appearances of other people and reshape their bodies at will, Killer Crocnote a man with a rare genetic deformity that gives him crocodile-like characteristics, Ra's Al-Ghulnote the seemingly immortal leader of an Ancient Conspiracy dedicated to steering society, and in one continuity is also Batman's mentor, Talia Al-Ghul, note Ra's loyal daughter who's often either a foe or Love Interest to Bruce, Deadshotnote a Professional Killer with almost supernatural aim, Banenote an exceptionally intelligent man who was raised in a prison and experimented on with a combat drug, Mad Hatternote a madman obsessed with Lewis Carroll's Alice in Wonderland, and Black Masknote a crime lord obsessed with masks; the mask he wears was fused with the skin of his head after a fire.. He's also got a bunch of lower-tier villains like Killer Moth, Firefly, Ventriloquist and Scarface, Tweedledee and Tweedledum, the Great White Shark, Narcosis, the Court of Owls, Professor Pyg, Dr. Dadelus, Ten-Eyed Man, KG-Beast, Black Spider, Lock-Up, Steeljacket, Orca, Roadrunner, Dr. Phospherus, Lord Death Man, Flamingo, Wrath and Cluemasternote The father of Stephanie Brown. Hadn't really used his gimmick since her introduction.
Batman's former sidekick Nightwing has his own gallery, including villains that have plagued him from his days with Batman and the Titans: Blockbuster, Torque, the Tarantula, Nite-Wing, Double Dare, Hellhound, Amygdala, Deathstroke, the Pierce Brothers. In a subversion, one of them is Shrike, an assassin Nightwing befriended while undercover receiving assassin's training. He thinks that he's Nightwing's worst foe; in reality, Nightwing doesn't even consider him a threat, on one occasion ignoring him and walking away while Shrike chased after him, trying (and failing) to hit him.
Deconstructed in Bates and Weisman's version of Captain Atom, in which Cap had a fictitious rogues' gallery that the military designed for him as part of his publicly-revealed false origin. Since that origin was his original, Silver AgeCharlton origin, his fake rogues' gallery, most notably Dr. Spectro, were drawn from his actual Charlton stories. On top of which, some of these fake villains later becamereal ones. Plus which, they, along with many of his other actual rogues, including, again, Dr. Spectro, as well as Major Force, The Ghost (at one time), and Wade Eiling, worked for the same secret military project he himself worked for. He also had "regular" rogues like Plastique, The Cambodian, and the Queen Bee.
Enemies peculiar to the Golden Age Flash Jay Garrick included the Turtle, the Thinker, the Fiddler, the Thorn, the Eel, Star Sapphire (an alien queen from another dimension and not to be confused with the similarly-named Green Lantern villain, though later revealed to be a former Zamaron queen), the Rival (Jay's own Reverse-Flash, who wore a darker version of Jay's costume with a mask), Rag Doll, the Shade, and Vandal Savage.
Barry Allen has an impressively large Rogues Gallery, the most recognizable of which include Captain Cold, the Trickster, Mirror Master, Captain Boomerang, Weather Wizard, the Shade, Pied Piper, Gorilla Grodd, Heat Wave, Golden Glider, the Top, Professor Zoom/Reverse-Flash, etc. They were also marked being a really unambitious bunch, considering they all have some incredibly powerful tech and the best use most can think of is simple robberies of local targets. It's implied that many are at least as unstable as Batman's. Most actually called themselves "The Rogues" and are unusually social for supervillains. Gorilla Grodd, the original Reverse Flash, and Zoom are not members of and actually hate the Rogues (the feeling is mutual — the fact that said three villains are probably the most heinous of the Flash's foes is implied to play a large part in the mutual dislike). The Rogues, in turn, have shunned other members of the Flash's Rogues Gallery, such as Abra Kadabra and the Rainbow Raider/s, though they will tolerate them when something big comes up (like Captain Boomerang's funeral) or when their goals coincide.
On the flip-side however, the Rogues have occasionally undergone a Darker and Edgier transformation to basically became Central City's version of the Mafia. While their gimmicks were still silly, they were unrepentant killers who were considered very dangerous.
Depending on when the comics were printed, some of Wally's Rogues were sometimes depicted as being Punch Clock Villains who were actually almost friendswith the Flash. Notably, scenes like this◊ actually happened in the comic, not just on the cover (that one happened because the Trickster sent Wally an invitation to a Rogues party as a joke - Wally had a date and no better ideas, so he decided to take him up on the invite. All involved find themselves having a surprisingly good time).
Bart Allen's tenure as the fourth Flash isn't really long enough to build up a separate Rogues Gallery but, in addition to fighting Barry Allen/Wally West villains, he has Griffin, Superboy-Prime and even gains an arch-enemy of his own, Inertia.
Each Green Lantern to headline his own series has had a collection of recurring foes, though they rarely if ever have teamed up collectively.
Alan Scott: Vandal Savage (arguably his archnemesis), Solomon Grundy, the Sportsman, the Icicle, the Gambler, the Harlequin (who actually only became a villain in the first place to date, and, subsequently, marry Alan) and the Thorn (the mother of his two children).
Kyle Rayner: Major Force (on loan from Captain Atom and not really his archnemesis, but he's loomed large in Kyle's life anyway, thanks largely to what he did to his first girlfriend), Oblivion, Grayven, Effigy, Alex Nero, Fatality, Sonar II, Amon Sur and acquired Brainwave JR, Dr. Light, Dr. Polaris and Hal Jordan as Parallax. Kyle, in an issue of his comic, bemoans the fact that he has a lousy Rogues Gallery, compared to his friend Wally West (The Flash).
As of Green Lantern: Rebirth and the subsequent relaunch of the franchise, Hal and Kyle's galleries have more or less merged into a collective Rogues Gallery for the entire Green Lantern Corps, with the additions of Parallax, Mongul, Cyborg-Superman, Superboy-Prime, Krona, and the Sinestro Corps.
Furthermore, the GL Corps now have their own rival factions, including the Red Lanterns, Black Lanterns, Agent Orange, and the aforementioned Sinestro Corps. The Star Sapphire name is now applied to a corps as well, although they don't have any designs towards antagonizing the Green Lanterns.
The Shazam Captain Marvel: the Rogues Gallery includes Dr. Sivana (and all four of his children), Mr. Mind, Black Adam, Mr. Atom, Ibac the Invincible, Sabbac, Oggar, King Kull, the crocodile-gangsters of Planet Punkus, etc. Most (save Black Adam) haven't appeared much lately, but they tend to congregate as the Monster Society of Evil.
The Monster Society has the distinction of being the first recurring villain team in comics. So it was Captain Marvel's gallery who first came up with the idea of teaming up to destroy the hero (a tactic which proved about as successful as it usually does.)
The only unrepentantly evil members of the Sivana Family are Dr. Thaddeus Sivana, Georgia, and Sivana Jr. Magnificus and Beautia both pulled Heel Face Turns and became at the very least Law-Abiding Citizens who are mostly embarrassed by their family, if not outright allies of the Marvel Family.
To be fair, Darkseid and other elements of the Fourth World were introduced in Jack Kirby's Jimmy Olsen comics, so they were, by extension, always a part of the Superman Mythos. And, in any case, their storylines were awesome. It should also be noted that Darkseid and his minions had already been introduced and had been recurring archenemies for Superman in the comics for several years before Superman: The Animated Series was even produced and aired.
Supergirl has her own gallery, including Mad Scientist and body-swapper Lesla-Lar, Kryptonian criminal Black Flame, sword-wielding Amazon Nightflame, Satan Girl (name shared by three vastly different enemies), reality-warper Nazi Blackstarr, super-powered Darkseid minion Powerboy, mass-murderer bounty-hunter Lobo, Metallo expy and genocidal thug Reactron (who killed post-Crisis Supergirl's parents and blew New Krypton up), corrupt businessman Simon Tycho, Super Soldier Reign and the remainder world-killers -biological super-weapons-, Kryptonian werewolf Lar-On, Cyborg-Superman, and many more.
In addition to their individual enemies, the Justice League of America had a handful of villains that regularly fought them as a team: Amazo, Despero, Starro the Conqueror, Kanjar Ro, Starbreaker, The Shaggy Man (later known as the General), The Queen Bee, and Prometheus, to name but a few. Two of the most famous villain teams are the Injustice League and the Secret Society of Supervillains.
Carol Danvers has had a varied gallery, including enemies who were created specifically for her to fight but who are now better known as members of other heroes' galleries. Three foes who fall in that category include Mystique (her original Arch-Enemy), Deathbird, and the Brood alien race (all better known as X-Men villains these days), plus Carol has also had to deal with the Skrulls (who tend to fight other heroes as well as her), Moonstone, Toxie Doxie, Grace Valentine, Destructor and Doomsday Man (respectively, a man who wore Powered Armor and a cyborg, and who both got fused into one individual later), the Storyteller, sorcerer Warren Traveler, and Kree commander Yon-Rogg. Newer additions since she became a cosmic hero include Hala the Accuser and Dr. Eve.
Naturally Doctor Strange, the Sorcerer Supreme of Marvel Comics, has a rogues gallery, although it's extremely unusual. Strange's foes range from other human sorcerers (Baron Mordo) to demonic entities from other dimensions who want to take over the Earth (Nightmare, Dormammu, the Dweller-in-Darkness) to out-and-out Eldritch Abominations (Shuma-Gorath) to ancient super weapons left behind (Zom). To complicate matters, sometimes these entities use humans as agents or vessels to attack Strange when they can't go after him directly (e.g. Dormammu possessing The Hood).
Different incarnations of the Ghost Rider had their own rogues galleries, including both demonic and otherwise supernatural villains like Mephisto, Blackheart, Deathwatch, Blackout, Hag & Troll, Null the Living Darkness, Wallow, Vengeance, Centurious, and Lilith, and more conventional costumed villains like the Orb, the Water Wizard, Steel Wind, and Marvel's own version of the Scarecrow.
Even Howard the Duck had an off-kilter Rogues' Gallery, headlined by recurring nemeses Doctor Bong and the Kidney Lady, and including the likes of Pro-Rata, the Cosmic Accountant; Doctor Angst, Master of Mundane Mysticism; Betsy the Hellcow; and Le Beaver.
Bruce Banner's cousin Jennifer Walters, also known as She-Hulk, has her own list of enemies, likewise consisting of super-strong bruisers such as her Arch-Enemy Titania and others like the Abominatrix, Adrenazon, and the Behemoth, but also including other super-powered foes like the Countess (a reality-warper), Bulldozer (the daughter of the original Bulldozer from the Wrecking Crew), the Grappler (a martial artist who uses gadgets to fight), the Word (a cult leader) and his daughter Ultima, Madcap (a crazy fellow with incredible healing abilities), Ruby Thursday (Android/Cyborg, who knows?), Black Hole (a man who can create a black hole from his chest), and Frenzy (a mutant whose skin is hard as steel) and even non-powered villains like extortionist Beverly Cross and crime boss Nicholas Trask. Being the Hulk's cousin and ally, she's also butted heads with some of his enemies, including the Abomination and the Grey Gargoyle, and with villains from other rogues' galleries such as Venom and Juggernaut.
Since Iron Man began as a vehicle for Cold War stories, his gallery were nearly all communists — the Mandarin (not technically a communist but more of a Yellow Peril), the Crimson Dynamo, the Unicorn, and the Titanium Man. Eventually, when the Cold War threats died down, his enemies became tailored to be antagonists to a playboy industrialist millionaire: Iron Monger, Justin Hammer and Sunset Bain (two business rivals), Doctor Doom (a dictator and technocrat who has what may be an even more powerful suit of armor than his own), the Ghost (an industrial saboteur), Whiplash/Blacklash (one of Hammer's longtime employees), the Blizzard (an embittered ex-employee who was fired by Stark for stealing from the company, and created his own suit of armor in an attempt at revenge), Firebrand (a radical anarchist determined to destroy capitalism and lead a utopian revolution), the Spymaster (an industrial spy), Madame Masque (a masked criminal saboteur, as well as an on-again, off-again girlfriend), Firepower (an armored warrior sponsored by the U.S. government, who wanted to destroy Iron Man when they thought he had gone rogue), the Melter (a crooked industrialist who was run out of business and set out to sabotage Stark Enterprises), Sunturion (another armored warrior who worked for a rival company), and the Living Laser (a psychopath with deadly laser blasters strapped to his wrists, who started out lusting after one of Iron Man's teammates but soon developed a loathing for Iron Man himself).
Then there's Fin Fang Foom, because you can't have a hero in shining armor without a bona fide fire-breathing dragon to fight. Foom also hates the Mandarin, because the Mandarin stole his ten power rings from Foom's spaceship (yes, Foom is a fire-breathing Chinese dragonfrom space. And that is awesome).
The martial artist Shang-Chi has often fought Zaran, the Cat, Pavane, Kogar, Mordillo, Tiger/Claw, Ghost-Maker, Razor-Fist and Shadow-Stalker. But more importantly he fought Midnight Sun (his adopted brother), Moving Shadow (his half brother), Fah Lo Suee/Cursed Lotus (his half sister) and big bad Fu Manchu/Zheng Zu (his father).
Luke Cage has a number of foes who have similar origins to him (that is, born under poor circumstances and eventually taking up crime, though Cage himself reformed), and although many of them don't have superpowers, they make up for it by having some kind of physical superiority or high-powered weaponry. These include Cockroach Hamilton (wields a six-barreled shotgun that pulls double-duty as a flame-thrower), Black Mariah (a 400-pound drug dealer with exceptional strength), Cornell Cottonmouth (an elderly drug kingpin and pimp with photographic memory), Hardcore (a mercenary with medically-enhance nails capable of slashing through steel), John Bushmaster (not the same as the Bushmaster from Iron Fist's gallery; this one is a crime boss with powers similar to Cage), Chemistro (an identity borne by three different individuals, all of whom have alchemic abilities), Cheshire Cat (able to turn invisible and intangible and also able to teleport), Stiletto (fights using wrist-mounted blade-launchers), and Piranha Jones (a crime boss with metallic jaws and teeth). Three other enemies of Cage's, Billy Bob Rackham, Willis Stryker and Coldfire, loom much more largely in his life, as Rackham was a prison guard whose attempt to kill Cage wound up giving him his powers, Stryker was the one who framed Cage and sent him to prison in the first place, and Coldfire is Cage's brother who hated him for his formerly criminal lifestyle. Also Shades and Comanche
The Mighty Thor's rogues gallery is a strange mishmash of mythological villains and costumed criminals. Some of his enemies are derived from Norse Mythology, like his brotherLoki, and the fire giant Surtur, and those who hail from the worlds of myth but were created by Stan Lee like Ulik the rock troll, Amora The Enchantress, and Skurge the Executioner, but even in the early Stan Lee-scripted stories he fought mortal villains like the Wrecking Crew, the Absorbing Man, Mister Hyde, the Cobra, Radioactive Man, Zarrko, and the Grey Gargoyle.
Sub-Mariner aka Namor has a host of enemies. Attuma, Tiger Shark, Llyra, Llyron, Orka, Krang, his cousin Byrrah, Dr Dorcas, Tyrak and his frenemy Dr Doom.
Nova has a moderately-sized group of enemies such as Condor, Diamondhead, Megaman, the Corrupter, Powerhouse, Supernova and Sphinx.
While (for rather obvious reasons) The Punisher has a small rogues gallery in the sense of recurring targets... Jigsaw is the most long-running character he's ever had to deal with, even when the original Jigsaw was killed in the regular Marvel Universe, as Stuart Clarke eventually "succeeded" him, although Nicky Cavella (2 arcs) and Kathie O'Brien's husband Rawlins (3), and finally the Generals briefly joined in the MAX universe under Garth Ennis' years as author.
Barracuda, the Made of Ironbackstabbing mercenary introduced in the MAX universe, also lasted for a few arcs and got his own miniseries. After surviving a ridiculous number of injuries throughout the series, Barracuda was finally Killed Off for Real after Frank tore off his nose with a pair of pliers, chopped off his arms, and blew his head off with an AK-47.
Terrorist-for-hire Saracen had a sixteen-issue run in the 616 universe.
The Kingpin is also a major recurring enemy to Frank, in both the 616 and MAX universes. In fact, as explained on Fisk's character page, the only reason he's survived so many encounters with the Punisher is because even Frank recognizes the massive power vacuum and accompanying deaths of innocents that would result if Kingpin were to die.
Moon Knight has Bushman, Stained Glass Scarlet, the Profile, Sun King, Black Spectre, Midnight Man and later his son, Morpheus, the Hellbent, Slasher and Moon Knights brother Shadow Knight.
Sleepwalker had a strange collection of original villains, including costumed criminals (8-Ball, the Chain Gang, Spectra, Psyko), uncostumed villains (Lullaby and the Bookworm), crazed government agents (the Office of Insufficient Evidence, the Thought Police), and supernatural demons (Mr. Jyn and Cobweb). In his short career, Sleepy also found time to mess with the villains of the X-Men (Brotherhood of Evil Mutants), Spider-Man (the Hobgoblin), and Doctor Strange (Nightmare).
The villains are also good examples of villains crossing over to fight new heroes besides their traditional sparring partners. Electro, for example, has become an enemy to Daredevil as well as Spider-Man, while Spidey himself has thrown down with the enemies of everyone from Iron Man to the Hulk to Captain Marvel.
Spider-Girl, his daughter, has a nice rogues gallery as well. Crazy Eight, Killerwatt, the Dragon King, Funny Face, Soldiers of the Serpent, Quickwire, the Hobgoblin, Earthshaker, Mr. Abnormal, Aftershock, Apox, Angel Face, Fury the Goblin Queen, Mr. Nobody, Carolyn Trainer, Killer Frost, Reverb, etc. She even inherited a villain from her father's rogues gallery in the form of Black Tarantula.
Due to villain attrition, such as the death of Kraven and the reforming of Sandman as a hero, the Sinister Six has seen a lot of villains take part of the sextet as Doc Ock sought to fill up the empty slots any way he could just to preserve the group name. This has actually lead to the Six's downfall on a few occasions, due to Ock picking a villain who isn't really a team player. for example the one time they let Venom join, his mental instability and obsession with being the one to kill Spider-Man resulted in him going rogue mid-battle, crippling Sandman with a poisonous bite, and basically ruining the plan just as they were about to win. Generally Spidey's villains don't play well with each other.
Miles Morales: As the younger Spider-Man, Miles has his Uncle Aaron (Prowler, Iron Spider), Bombshells mom, Tomoe, Ceres, Snatcher, the Assessor, the female Electro, Hammerhead, Ultimatum, the Ultimate Green Goblin and the Spot.
Spider-Gwen aka Ghost-Spider (2019): has her universes Kingpin Murdock, The Lizards, the S.I.L.K. Organization, Koala Kommander, the Black Cat, the Punisher, the Bodega Bandit, the Vulture, Man-Wolf and now the main Marvel universes Jackal.
Venom: While Eddie Brock and the symbiote have traditionally been part of Spider-Man's rogues gallery (as outlined above), they have also developed a gallery of their own as they've shifted from outright villainy to being more anti-heroic. A big constant in their list of adversaries is Carnage, the Venom symbiote's offspring which has been a recurring foe both on its own and when bonded to its usual host Cletus Kasady; but other enemies Venom has had to endure—regardless of who the symbiote is bonded to at the time—include Jack O'Lantern (the fifth person to wield the name and outfit), Killer Thrill, Sin-Eater, The Jury (whose leader formed the team after Venom killed his security guard son while escaping the Vault), Pyre, Scorpion (the third Venom host), Krogg, The Redeemer, and Knull (the deity who created the symbiotes).
Making things even more complicated, a few X-Men have their own Rogues galleries! Wolverine has everyone ever involved with the Weapon Plus project (Sabretooth, Lady Deathstrike, etc.), Jean Grey (thanks to being the incarnation of the Phoenix) is on the entire Shi'ar Empire's shit list, and Professor X himself has personal issues with Magneto, the Shadow King, Cassandra Nova, and Cain "Juggernaut" Marko. Cyclops and his brother Havok are of special interest to Mr. Sinister (who has up to THREE teams of Psycho for Hire assassins!) and have their psychopathic Omega class brother Vulcan to deal with, Beast has to deal with his Age of Apocalypse Evil Counterpart Dark Beast, Banshee and Black Tom are cousins, and Colossus has a Cain and Abel dynamic with his brother Mikhael Rasputin. The X-Men have so many enemies it's a wonder how they keep track of them all. And while some of the above are currently dead, this is X-Men, so they'll probably be back.
Excalibur has had Arcade, Doctor Doom, Galactus, the Hellfire Club, Juggernaut, Mister Sinister, Mystique, Nightmare and Sentinels.
Likewise to the JLA and JSA, The Avengers fought both the enemies of their individual members (such as Loki and The Red Skull) and their own collective enemies, including Ultron, Kang the Conqueror, Graviton, Count Nefaria, and the various incarnations of The Masters of Evil.
They also have a tendency to "borrow" Magneto and Doctor Doom, presumably because the X-Men and the Fantastic Four can't be bothered on some days.
In the very early stories written by Stan Lee, even the Human Torch and Ant-Man had their own rogue's galleries before they became full-time team heroes. The Torch faced off against the Beetle, Plant-Man, the Trapster, and the Wizard, while Ant-Man battled the likes of Whirlwind, Egghead, and the Porcupine. The Wizard went on to become a significant threat to the Fantastic Four, while the rest of them languished as minor villains... they weren't Stan's best creations.
The New Warriors have squared off with the likes of A.I.M., High Evolutionary, the Sphinx (both the male and female version), Juggernaut, Skrull, Terrax, the Folding Circle, Psionex, Asylum, Harrier and Midnights Fire.
Before they lost their powers en masse, the Order of Despots was this to the Pantheon in All Fall Down.
Disney Ducks Comic Universe: A non-superhero example would be with Scrooge McDuck, most notably in the comics by Carl Barks and Don Rosa. Along with the BeagleBoys, who are constantly trying to rob Scrooge blind, he has to contend with Magica De Spell, an evil sorceress who constantly tries to steal Scrooge's #1 Dime because she thinks it has magic powers; the snooty John D. Rockerduck, who simply inherited his money instead of working for it like Scrooge did; and FlintheartGlomgold, who has all of Scrooge's drive and determination but none of his ethics or morals. There's also Blackheart Beagle, the Beagle Boys' grandfather, founder, and occasional leader who is depicted as Scrooge's Arch-Enemy and is constantly trying to rob Scrooge blind with the aid of his family The Beagle Boys. Later day additions include the country of Brutopia and Arpine Lusene, who's out to steal Scrooge's money simply to show that he can, or, at the very least, make it disappear so he can claim he did.
The Beagle Boys, Flintheart, and Magica all became regulars on DuckTales.
Interestingly, while both come from the original canon, Rockerduck and Flintheart rarely if ever are featured in the same canon in modern comics. In America Flintheart is prevalent while in Europe Rockerduck is more famous, and as a result hardly any American fan is aware of Rockerduck and the same applies to European fans for Flintheart, which resulted in their personalities to have evolved over time to be the same. Thus, you can call Rockerduck "Europe's Flintheart" and Flintheart "America's Rockerduck".
Scrooge's Rogues Gallery is actually lampshaded in the first episode of the DuckTales reboot, when Scrooge learns that Donald's new job is with Flintheart Glomgold.
Across the G.I. Joe franchise, the Joes consistently do battle against the Cobra Command terrorist organization in one form or another (not always paramilitary, such as in G.I. Joe: Renegades where it's Cobra Industries, a pharmaceutical conglomerate). Members of the Cobra group include Cobra Commander, Destro, the Baroness, Storm Shadow, Zartan, Dr. Mindbender, Black-Out, and Serpentor (who temporarily took Cobra Commander's place as leader of Cobra), while mercenaries Major Bludd and Firefly occasionally grant their services to the organization.
Judge Dredd has a rather small gallery, since (much like Punisher) most of his enemies end up dead, and many of those that he sends to prison don't pop up again. Recurring villains include Judge Death (who's an immortal undead), PJ Maybe (who's both incredibly lucky and a master of escape), and the recently retired Mean Machine Angel. One could perhaps also add Orlok, though he tends to tangle more with Anderson.
Knuckles has one of his own, most of whom were introduced during his spinoff and later incorporated into the main series after the spinoff's cancellation. These include Dimitri / Enerjak, Finitevus, the Dingo Regime (specifically when led by Kage Von Stryker), and the Dark Legion. The Legion eventually joined forces with Eggman, so they can be considered part of Sonic's Rogues Gallery, too.
The Continuity Reboot triggered by Ken Penders' lawsuit of Archie's continued use of characters he created has caused most of the Archie Sonic rogues gallery to be removed from the series. That being said, it's also seen the introduction of numerous new villains to fill the gap, including Eclipse (Shadow's Evil Knockoff), Breezie the Hedgehog, and Phage.
Vampirella: Vampirella has had a shifting rogues gallery over the years. Some of her most frequent recurring enemies include Dracula, the progenitor of all evil vampires; the MadGod of Evil Chaos, who rules over Hell; Von Kreist, an undead Psycho for HireSerial Killer; and the Blood Red Queen of Hearts, a body-hopping demoness.
Averted in Watchmen: One of the reasons the first wave of masked crime-fighters didn't work out well was that there weren't nearly as many villains that wore costumes, and they just ended up convincing criminals to work in less conspicuous ways.