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Western Animation / Ozzy & Drix

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Lookin' good like a blood cell should!

"It’s a cold, it’s a fever, or maybe the flu! A... AA... CHOOOOOO!"
From the theme song

Ozzy & Drix (2002-2004) is an animated spinoff from the movie Osmosis Jones. In this Anthropomorphized Anatomy universe, Ozzy is a white blood cell who recently moved to the "City of Hector" (they were still in Frank at the start of the series but a mosquito bite while fighting a virus transferred them to a new body) and now fights cri—uh, illness—with his partner and friend, a pill named Drix. Each episode covers a topic of health and safety such as cavities, flatulence, or nicotine dependency.

The entire series was released to DVD via the Warner Archive in 2017. As of April 2022 it is also available on most digital stores.


Tropes the series has:

  • Action Girl: Vitamin E, of the superheroes Supplements, who is quite capable of fighting alongside her male partners.
    • Maria Amino also fits this given she's in the police.
  • Adjacent to This Complete Breakfast: Weirdly subverted as the chocolate cereal Hector eats when lead poisoned actually DOES contain healthy vitamins.
  • Aesop Amnesia: The spin-off's first episode shows that whatever Frank learned about health didn't stick, and his life seems to have spun out of control. For the brief time we see him, he's eating chicken in a trailer park. A more friendly interpretation would be that the cartoon is set in an Alternate Continuity, where the film's plot didn't happen; note that Shane isn't present, and that Ozzy, despite his accomplishments in the film, mentions being on Snot Patrol in the pilot episode. Even the garage Thrax took refuge in, then burned to the ground, is intact.
  • All Animals Are Dogs: Dander, who is, in this case, a dog germ. From an actual dog. An episode after Dander's debut reveals at the finale, where Ozzy's doppleganger is hurled from Hector into the open mouth of Hector's dog Uno, that every germ and whatnot on a dog is dog shaped.
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  • All Your Base Are Belong to Us: In one episode a gang of testosterone managed to stage a coup d'etat within Hector through a combination of peer pressure and cunning. Unsurprisingly, their leader promptly used his newfound power to turn Hector into a frat boy.
  • Amazon Brigade: The white blood cells in Christine's body
  • And Knowing Is Half the Battle: While not as blatant as some other shows of this type, there were several episodes that had lessons about healthy habits.
  • Animesque: Even though it was based on an American movie and animated in Taiwan and Korea. This came out during the rise of anime-styled shows, though, so it's possible it could have been an attempt to cash in on them. Hector especially looks animesque.
  • Anthropomorphic Personification: See below.
  • Anthropomorphized Anatomy: Much like its source material, it is a story of cells in the human body depicted as people.
  • Big Eater: Hector's fat cells, due to it being their sole purpose. Especially since Hector has been eating a lot lately in "A Growing Cell".
  • Brain with a Manual Control: Zig-Zagged
    • In the episode "Reflex", Ozzy the white blood cell inadvertently causes his host human Hector to tick off a bully, who challenges him to an after-school fight. Ozzy tries to amend his mistake by sneaking into Hector's brain's manual control room and linking their bodies so that Ozzy can use his martial art skills to control Hector in the fight. However, he gets caught by security in the process, turning it into What the Fu Are You Doing?.
    • The fear center is also seen in "The Globfather"; Drix turns everything off to trick Hector into going on a nausea-inducing carnival ride, so that he vomits up a disease-ridden corn dog.
    • Played With in "Dream Factory"; the subconscious parts that control dreams are revealed to be outside the Mayor's control, but that doesn't stop the main characters from intervening when Hector gets recurring nightmares; it just takes more than simply switching off the dream.
    • Subverted in "An Out of Body Experience Pt.2", when Drix tries hacking Hector's fear center to undo his fear of swimming. The network turns out to be too difficult for him to decode, but Hector ends up overcoming his fear himself.
    • Subverted again in "Where There's Smoke": Nick O'Teen tries to hijack Hector's pleasure center to make him crave more cigarettes, but Hector, remembering his crush's disapproval of him just trying one, still manages to refuse and walk away.
    • Played With again in "A Cold Day in Hector": Ozzy tries using the brain's manual control room to keep Hector moving, but the hypothermia Hector is suffering renders the controls almost unresponsive; Ozzy describes it as trying to move through snot. When Hector wakes up and sees a rescue team, Drix tries desperately to find a Shout button to get their attention; when the rescue team is about to leave, he just panics and slams a bunch of buttons, causing Hector to loudly burp. (Thankfully this works.)
  • Bratty Half-Pint: Mayor Spryman is a stuck up punk, though he runs a teenager's body so it's justified. Probably represents Hector's current egoist mentality.
  • "Brave the Ride" Plot: One episode centers around the characters trying to convince Hector to ride an intense drop tower at the amusement park, because he had unwittingly eaten contaminated food and needs to throw it up urgently.
  • Cassandra Truth: This happens to Ozzy a lot, as the other cells in Hector's body have no idea what a lot of the things he's seen back in Frank are. In particular Nick'O Teen, as they're not even able to understand the concept of addiction to smoking.
  • Captain Obvious: A random cop when one of the mayor's political opponents is talking in Hulk Speak.
    Cop: Sir! The serum seems to have impaired Sylvian's intellect!
    Chief of Police: Gee, do ya THIIIIIIIIINK?!?!?!
  • Catchphrase: "I'm unbeatable!" for Nick'O Teen. Becomes his last words as he shrinks away to nothing and is stomped out by Ozzy after Hector refuses a second cigarette.
  • A Child Shall Lead Them: Mayor Spryman is probably the youngest character in Hector, come to think.
  • Clark Kenting: Parodied with the Supplements, who are still wearing their costumes, and are disguised only with a pair of glasses.
  • Clipped-Wing Angel: Nick'O Teen burns himself out trying to brute force Hector to smoke again after Hector refuses, reduced to a pathetic powerless form, that Ozzy finishes off by stepping on him.
  • Cold Ham: Scarlet Fever.
  • Cool Car: Backseat, a fully automated car with all the bells and whistles and who is even capable of speech.
  • Compressed Vice: Any episode that wasn't about a singular jarring incident (such as a concussion or eating undercooked meat) was treated this way, which occasionally led to bizarre "lessons" that come out of nowhere. Notable examples include Hector getting hooked on junk food for a few weeks, only to completely change tack when he goes for a single jog, and a few days of a nasty attitude when puberty kicks in.
  • Concussions Get You High: Averted; in one episode when Hector hit his head skateboarding, he displays real symptoms of a concussion such as intense dizziness and confusion; Drix even notes that if Hector DOES fall asleep concussed, he might never wake up.
  • Continuity Snarl: When Ozzy goes outside of Frank's body in the movie to face the Big Bad, he's perfectly capable of surviving more than a few minutes. In the show, going outside of Hector's body causes him to coagulate. Though it's believed Ozzy was covered in Shane's tears which gives him protection from coagulation.
  • Corrupt Politician: Well, Mayor Spryman sometimes acts this way, but not always. And in his defense, one rival candidate that challenged him was far worse, causing Hector to experience growth spurts on purpose and blaming Spryman for it in order to discredit him, the biological equivalent of political fraud.
  • Da Chief: Chief Gluteus serves this role for the HPD.
  • Disease-Prevention Aesop: Nearly every episode has a lesson on staying healthy, which is logical, considering the main characters are medication and a white blood cell.
  • Distaff Counterpart: In "An Out-Of-Body Experience (parts 1 and 2)," while in Christine's body, Ozzy finds Drixene, a green-and-yellow female version of Drix, while Cilia Tyson is Ozzy's. Drixene, Clia and Ozzy end up helping each other save Christine when Christine's Chief of Police is bribed to let the Pneumoniac take over Christine. At the end of Part 2, Cilia has been named the new Chief of Police.
  • Evil Brit:
    • Nick O'Teen. Smooth smoky British accent? Check. Villain of the episode? Also check.
    • Also Scarlet Fever. They're both voiced by Tim Curry, who's made of this trope.
  • Evil Twin: Mitosis, Ozzy's double in the episode "Double Dose", who knows full well he'll be rejected due to his mutation unless the original is eliminated.
  • Expy:
    • Chief Gluteus (Chief)
    • The Mole (the flu shot)
    • Mayor Spryman (Mayor Phlemming)
    • Ellen Patella (Leah)
  • Failsafe Failure: When Ozzy tries to trigger the puke reflex to flush the Lead Gang out of Hector's body, they destroy the switch.
  • Family-Unfriendly Death: Some villains are dispatched in nasty ways. A good example is Scarlet Fever, the first villain, being flown into the spleen and chopped to bits. We even see his remains afterwards.
    • Another more graphic example is Nick O'Teen's gang Carbon Monoxide, Butane and Tar being killed via electrocution through a busted nerve.
  • Four Eyes, Zero Soul: Sylvian Fisher. Even after he becomes a Hulk-like monster, he keeps it on.
  • Gender Bender: Osmosis turning into a female, when he ends up inside a girl's body.
  • Genius Loci: Hector is this to the cells living inside him; they also seem to regard him as their god. It's implied that other cells view the humans they inhabit the same way.
  • Good Counterpart: Iron, he's also a metal, but unlike the Lead Gang, he's good for the body.
  • Go On Without Me: Parodied in the lice episode, when Ozzy's suit is breached as they're running from the mother louse, slowing him down due to him coagulating.
    Drix: Do you really mean that?
    Ozzy: Of course not! Save me! Save my butt right now!
  • Gory Discretion Shot: Lampshaded by Ozzy when the 'camera' cuts away from Iron beating the daylights of the Lead Gang.
  • Happy Ending Override: Osmosis Jones ended with Frank strongly implied to have changed his habits after nearly dying, but the pilot shows he's resumed his prior unhealthy lifestyle (before Ozzy, Drix, and Scarlet Fever are transferred to Hector by a mosquito). That said this is a more vague example as there are various hints that this show takes place in an alternate continuity, making it ambiguous if there was a happy ending to override.
  • Interspecies Romance: Maria the white blood cell and Drix the cold pill.
  • Jerk with a Heart of Gold: Hector's best friend Travis. He tends to make fun of Hector's troubles, teases Hector over his weight gain, and has given bad advice on a couple occasions like daring him to eat a 12 bean salad that caused to have a gas attack, or suggested diving off the high dive at the pool to impress Christine. But when Hector is in real trouble or is making terrible life choices that could put him in danger, Travis steps up to the plate.
  • Kinda Busy Here: Exploited by Drix in the episode where Ozzy goes through mitosis and has to fight the resulting Evil Twin; When Ozzy and the twin are fighting, Drix determines who to shoot by calling Ozzy's phone. When one pickes up, Drix shoots the other one.
  • Lame Comeback: "Yeah, well... you ugly!" However, since this is such a lame retort that the Wicked Cultured virus he's exchanging insults with is at a loss for words, it ends up being an excellent comeback.
  • Lethal Chef: Hector attempting to cook breakfast for himself (specifically eating an undercooked chorizo) gives him a Trichinosis infection (a parasite that attacks the muscles, including the cardiac muscle.)
  • Loss of Inhibitions: Ozzy and Drix are forced to invoke this in "The Globfather" in order to make Hector go on a vomit-inducing carnival ride to vomit out Sal Monella and his gang before they can inflict food poisoning.
  • Mister Seahorse:
    • Subverted. Ozzy initially thinks he's pregnant (and is oddly happy about it too), but it turns out the "baby" is actually a parasitic virus that's been injected into him.
    • Played straight in another episode, where Ozzy creates a twin of himself via, well, osmosis. Unfortunately, said twin is mutated, making him evil.
  • Monstrous Germs: The show, just like its parent movie, portrays bacteria and viruses as monsters. For example, the Scarlet Fever looks like a red reptilian creature with a serpentine body, green eyes, sharp teeth, and appendages around its neck.
  • Mysterious Informant: The Mole, from requiring complex call-and-response passwords to always being seen in dark alleyways.
  • Near-Villain Victory: Many episodes have the virus or affliction very nearly succeed at their goal, either killing Hector, or seriously ruining his life.
    • In "Where There's Smoke", Nick O'Teen comes within a hairs breadth of making Hector addicted to cigarettes, with the only thing stopping him being the teenagers own willpower.
    • In "A Cold Day in Hector" Cryo almost succeeds at causing Hector to die of hypothermia. She's only defeated by a pure stroke of luck when Drix manages a massive charge to the spine causing Hector to shiver enough to overcome the cold as she's thrown into the electrical current.
    • The penultimate episode "When Nature Calls" has Billy Bob Bile very nearly cause Hector's appendix to burst via turning it into an overpacked inn for viruses and germs. Hector is only barely saved in the nick of time for an operation before it ruptured and the viruses that would’ve flowed into his bloodstream caused him to get sick or die.
  • Never Heard That One Before: When Ozzy catches up with Nick O'Teen, we get this exchange.
    Ozzy: Hey Nic, this is a no smoking area!
    Nick O'Teen: Yeah, you know that was funny the first five hundred times I heard it.
  • No Celebrities Were Harmed: Metabolica
  • Oh, Crap!: In "An Out-Of-Body Experience part 2", Ozzy has this reaction when he manages to call Drix, who tells him that if he stays in Christine’s body for too long, he’ll become a female cell.
  • One-Winged Angel:
    • Scarlet Fever, the first villain, transforms into a more powerful, muscular form after arriving in Hector, where he can spread more effectively. This is representing how Scarlet Fever is more dangerous to kids than adults.
    • When he overrides Hector's pleasure center, Nick'O Teen assumes transforms into a larger, more monstrous form.
  • Only Sane Woman: Officer Tyson is the only cell in Christine who dislikes Ozzy, even though he came from Hector. (Apparently, the cells in Christine's body are inclined to be favorable to the ones in Hector's because Hector and Christine like each other. It Makes Sense in Context, probably.)
  • Outside-Context Problem: While most of the villains are viruses or bacteria, some decidedly aren't:
    • The Lead Heads aren't virus' or bacteria, they're deadly commercials and heavy metal, so Ozzy and Drix's weapons are useless.
    • Nick-O'teen and his gangs are also dangerous chemicals, which make them unique dangerous and difficult to deal with.
    • Cryo isn't a pathogen in a germ, rather she's more accurately the Anthropomorphic Personification of Hypothermia and cold. This makes her not only far more difficult to defeat, but one of the most powerful enemies in the series.
    • "The Dream Factory" is about Ozzy and Drix trying to deal with a recurring nightmare Hector keeps having after seeing a scary movie. Their foe isn't even technically real and there's no real health Aesop to be had unlike most episodes of the show.
  • Pet the Dog: One of Nick'O Teen's henchmen gets zapped by a high voltage nerve cell, the other two try to pull him free and save him despite otherwise being as bad as their boss. This only results in them all getting caught in the blast and destroyed for their trouble though.
  • Pointy-Haired Boss: Mayor Spryman: Chief Gluteus calls him "incompetent" during his reelection.
  • The Power of Love: His crush on Christine and her disapproval of him smoking is what inspires Hector to not smoke a second time. It's the only thing that stops Nick O'Teen.
  • Punny Name: Pretty much everyone who isn't human and everything inside Hector's body that wouldn't exist in reality. Puns based on parts of the body, microorganisms, and biology in general, tend to happen a lot.
  • Shipper on Deck: Ozzy shows shades of this in the episode where he winds up stranded in Christine's body; his immediate response upon seeing Drixine is "Do I have the man back at home for you!"
  • Shout-Out
  • The Smurfette Principle: The proportion of characters' gender is justified as most characters are male because Hector is male; during an episode taking place within a girl's body, the reverse is true, and laws, norms, etc. are stereotypically feminine (such as a law against burping). Unfortunately, while the female cells in Hector's body seem to have no problem with it, a male one in Christine hates his job and actually turns against her, taking bribes from an army of pneumonia-causing bacteria that are planning an invasion.
  • Snap Back: The film the series is based on ended with Frank learning to live healthier, as well as Ozzy getting together with Leah. By the show's first episode, Leah has vanished and Frank is a slob again. Depressing.
  • Space Whale Aesop: Since poor health choices are usually a gradual process, they would usually speed up the consequences of Hector's decisions, which frequently led to this trope. The best-known example: Hector spends a few weeks eating too much junk food. Not only does he gain a large amount of weight in that time, but an insane performance artist named Stickety Lipid snatches a few fat cells, bloats them up, and plans to block a major artery. Thankfully, Hector saves his life by going for a single jog.
  • Speak Friend and Enter: When the characters hosted a contest for Kids' WB!, the answer was to say what color Ozzy would turn on Saturday. The commercial showed a brief animation of what was purportedly a future mid-episode game showing many Ozzys changing color, so viewers would initially presume that they had to wait until Saturday and watch for that special game. However, several ads showing clips from the new episode had already aired and Ozzy's wording was "What color I turn in the new episode?", so a careful listener could send in the correct answer (pink) having already seen it in the ads!
  • Spinoff Babies: Sort of? The Movie took place in an older man's body, but the series is moved to a teen's, most likely to be more "kid-friendly."
    • And added compatibility with the Very Special Episode. Actually not a bad way to show the negative effects of smoking, allergies, etc on the human body. Or at least far more entertaining than most.
    • If you don't push the metaphor too hard, it even makes sense that Ozzy would bring a veteran's knowledge of police work along to benefit the rookies in Hector's body. The immune systems of adults have usually developed a resistance to infections that kids' own defenses haven't yet learned to fight.
      • Or even needed to fight, as evidenced in the pilot episode with Scarlet Fever.
  • Starter Villain: Scarlet Fever, the villain of the pilot episode who gets taken alongside Ozzy and Drix from Frank to Hector.
  • Stock Footage:
    • Some clips from the movie can be seen in the show, and it isn't that hard to see it, especially with Drix being CGI instead of hand-drawn like he is in the show.
    • "Auntie Histamine" features the runny nose sequence.
  • Superhero: The Supplements are based off of this compared to the cells and other residents of the body.
  • Surprisingly Realistic Outcome: When a germ Billy Blob Bile creates a detour away from the small intestine so bacteria will come to his hotel, the Appendix Lodge, which will cause Hector's appendix to burst, and Ozzy, Drix, and Maria try to stop that before it happens. Ozzy and Maria both try to get Bile's two idiot nephews, who guarding the detour, away from it. Ozzy first tries by disguising himself as a germ, claiming that their uncle sent him to give them a break, even he says they're said their the best employees he ever had. But this turns out to be a mistake as they know their uncle would never say they're the best anything he ever had. Believe or not, even idiots know who someone well know what that person would or wouln't say about them. Then Maria tries by flirting with to let their guard down, and try flipping them over but because they are bigger and more muscular than her, she fails. Bile's nephews only leave when think bearasite, a vicious wild animal is coming.
  • Suspiciously Similar Substitute: Scarlet Fever, the villain of the pilot episode, is this to the movie’s Big Bad, Thrax.
    • Nick O'Teen also bares more than a few similarities to Thrax, from his Lean and Mean design to his glowing red claws.
  • Ungrateful Bastard: Mayor Spryman, Ozzy saves his ass more often then not and the little jerk can't even give a "thank you".
    • He even punished Ozzy, Drix, and Maria for trying to vote for his opponent in the election. He may have done the same for Gluteus for calling him "incompetent".
    • This exchange—immediately after Ozzy saves him from falling down Hector's throat to be dissolved by his stomach—says it all.
      Spryman: [seemingly happy that he was saved] Jones, when we get back...(angrily) You're buying me a new yacht!
      Ozzy: [to Maria] I could have dropped him. I should have dropped him! Why didn't I drop him?
  • Very Special Episode: The smoking episode, though most of the episodes cover something related to health or safety and have An Aesop related to it.
  • Vile Villain, Saccharine Show:
    • Pretty much follows the movie in terms of how dark many of the villains are despite the goofy tone. The worst is likely Strepfinger, a crimelord who seems to be a streptococcal pharyngitis ("strep throat") bacteria, whose Evil Plan involves launching a parasitic plague on the city using Ozzy as a carrier. (And it's almost successful.)
    • Nick O'Teen is another one, being the anthropomorphic embodiment of cigarette addiction. Not to mention his ability to turn cells into his zombie slaves, and the fact similar to Lead he's accompanied by not bacteria or viruses, but deadly chemicals. And he nearly wins, with the heroes failing to stop him and only Hector's own willpower defeating him.
  • Villainous Breakdown: Nick 'O Teen after Hector refuses to smoke of his own free will after Nick has already rewired his pleasure center. Nick tries to force him to, only to physical burn himself out and reduce himself to a tiny, weak form.
  • Villain Song: Nick O'Teen gets one in "Where There's Smoke," and considering it is Tim Curry singing...
  • Weaksauce Weakness: Bacteria can't resist anything sweet, and can be lured into a trap or ambush with simple pastry. (Of course, for a very big bacteria, you'd need a pretty big pastry.) Even the criminal mastermind Strepfinger was apprehended after Maria lured him out of his office with a pie. (After she knocked him out, she said, "You know, for an evil genius, you're pretty dumb.")
  • Whole Plot Reference: The tapeworm episode is pretty much one big reference to Jaws, with the tapeworm standing in for the shark (except the hunters win).
  • A Weighty Aesop: One episode has the Germ of the Week attempt to clog Hector's heart, which gets foiled when he goes for a jog.
  • The Wildcats: Hector's school nickname. For once, this trope is used without being abused.


Video Example(s):


Must smash Simon!

In "Growth", Sylvian Fisher, a meek and wily brain cell, has developed a powerful growth hormone formula. After being cornered by the police, Fisher ingests his own batch to become a familiar musclebound brute in purple pants. Trading his brains for brawn, he has a single-minded goal where he "must smash Simon!"

How well does it match the trope?

5 (3 votes)

Example of:

Main / HulkMashUp

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