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Comics (comic books, newspaper comics, etc.); by publication date

• "Mineternia" (first continuity): Skeletor is a being from another dimension, who ended up on Eternia by accident and decided to conquer it. Repeatedly trying to breach Castle Grayskull to learn its secrets, Skeletor would do anything to achieve his goals. In the past, Skeletor forcibly extracted part of a magical essence from Sorceress in order to create her duplicate, which he raised to be his wife. And when Man-At-Arms saved her from this fate, naming the girl Teela, Skeletor tried several times to brainwash her, and at one point tried to sacrifice her to a demon. In the present, abusing his minions, Skeletor creates the machine to steal the magic from all Eternia to power himself up, resulting in all magic users dying and Eternia being torn apart. Kidnapping the powerful flying machine Point Dread, Skeletor led the attack on Eternian palace, killing dozens of guards in his attempt to seize the Eternian throne.
• Second Continuity:
  • Skeletor, strongly hinted to be the long-lost brother of King Randor called Keldor, is a powerful warlock with a strong desire to conquer Eternia. Constantly trying to breach the walls of Castle Grayskull, Skeletor uses various schemes to get more power. One time, Skeletor used Man Eating Plants to attack an Eternian city with the intent of razing the place and killing all the people there in order to get to the royal family. Skeletor later tried twice to starve the Eternian people weaken their defenses, and ordered his minion Stinkor to pollute the ecosystem of the planet, simply because he didn't liked how happy Eternia was that day. Skeletor orders another one of his minions Spikor to burn down a village, while he kidnaps Teela to force He-Man to choose who he wants to save. Later, Skeletor tries to use his Stormbringer to cause destruction all over Eternia, simply to destroy Castle Grayskull. Going to the past, Skeletor tries to change history so he would be the only ruler of Eternia by manipulating King Hiss and helping him raze villages.
  • King Hiss himself is an ancient ruler of the Snake Men, who rampaged throughout the universe thousands of years ago, conquering several planets in his bloody campaign, before he set his eyes on Eternia, where he started burning everything down until he was banished to the timeless void by the Elders. In the present, he was freed by Skeletor, forming an alliance with him, while secretly planning to betray him. Telling Skeletor about three Towers of Power, King Hiss and Skeletor caused a dangerous earthquake all over Eternia in their attempt to raise them from the ground.
  • Hordak is a ruthless leader of the Evil Horde, who was banished to the Fright Zone of Etheria many years ago. At one point kidnapping princess Adora from Royal family of Eternia, Hordak starts to plot various schemes to conquer Eternia. Acquiring a magical Slime Pit, Hordak uses it to brainwash and transform He-Man into his slave monster, later on preparing to do the same thing to several peaceful Rock People from a nearby village. Experimenting on an innocent person, Hordak transforms him in to his deadly soldier, while intending to repeat the process on thousands of Eternian peasants. Creating a machine, which was capable of making near-indestructible soldiers out of the solid matter, Hordak prepares to raze Eternia, as he tries to transport his machine to Golden Isles, which would have destroyed them.

Masters of the Universe (1982 DC Comics miniseries)

• Skeletor is a demon who invades worlds, bringing death and chaos to every planet he visits. With the goal of conquering Eternia, Skeletor has kidnapped the Goddess, this story's version of the Sorceress, to force He-Man to get him 3 talismans that will allow him to gain the Sword of Power. Skeletor has his Beast Men attack Stratos's kingdom, just so that He-Man can discover one of the talismans there. Later, Skeletor teleports his minion Merman away to be tortured when Merman tried to gain the sword for himself. An evil wizard named Damon is trying to foil Skeletor, wanting to use the sword to conquer Eternia, but also fearing what Skeletor would do with the sword. Damon attacks Skeletor, their magical duel creating a wormhole that teleports Damon and Skeletor to the heart of Castle Grayskull, where the Sword is kept. Damon thinks he has outwitted Skeletor, but Skeletor reveals that he was playing dumb and knew of Damon's plan, letting him do all the work. Skeletor then kills Damon and obtains the sword. After being confronted by He-Man, Skeletor uses the sword's magic to summon He-Man's ally Man-E-Faces and mind controls him so that he tries to kill He-Man. Ultimately Skeletor plans to use the sword's power to start a campaign of carnage across the galaxy, starting with Eternia.

He-Man and the Masters of the Universe: The Newspaper Comic Strips

• Hordak is an alien conqueror from outer space and a former mentor of Skeletor. Tricking Skeletor into giving him control over the big comet, Hordak wastes no time turning on him and binding Skeletor and He-Man to his machine to suck away their power. When King Randor points out that Hordak's demand of transporting all weapons of Eternia to his ship in 30 minutes is not physically possible, Hordak happily sends the comet to Eternia in an attempt to destroy the whole planet. When Skeletor and Masters of the Universe break out from his prison, Hordak breaks the controls of the ship in an attempt to stop the Masters from changing the course of the comet. Later on, Hordak goes back to prehistoric times and enslaves a bunch of Etherians to force them to dig out a rare metal, from which Castle Grayskull will be made, in an attempt to stop the power of Grayskull from ever being created, so that Eternia would be free for the taking. Harshly abusing his slaves, Hordak attempted to murder them all when they rebelled against him.
• King Hiss is an ancient ruler of the Snake Men, who was imprisoned by the Sorceress thousands of years ago. Using the remaining Snake Men, King Hiss managed to free himself from his prison and immediately began gathering his forces to take over Eternia and enact his revenge on the Sorceress. Sending Kobra Khan and the army of snakes and reptiles to the Eternian palace, King Hiss joins Skeletor in an attempt to breach Castle Grayskull. When the Masters of the Universe defeat him, an enraged King Hiss uses Skeletor's staff and his own to summon the giant world-destroying snake Sarcedon to cause destruction all over Eternia out of spite.
• Evil-Lyn is a traitorous right-hand of Skeletor, who got tired of serving him and decided to go her own way. Recruiting mercenaries Blade and Saurod, Evil-Lyn orders them to distract the Masters of the Universe by causing trouble in the town of Ettlain, while she takes the form of a Thenurian female and befriends the Thenurian Gwildor solely to steal a gravitonic oscillation grenade from him. Ordering Saurod to burn the barn, which threatens to spread throughout the town, Evil-Lyn escapes with her cohorts to her hideout, announcing her plan to take over the planet of Merrian. Sending her partners there to prepare the planet for conquest, she uses her Thenurian female form to gain the trust of the Masters of the Universe, to have them travel to Merrian and tries to have Gwildor take control over Merrian. When he refused, she put him in a cage and tries to have the volcano Vuldan to erupt and kill many people.

Masters of the Universe (Star Comics)

• In this series, Skeletor starts off as an unremarkable villain, but becomes a nightmare by the end of the series. Skeletor tricks He-Man into getting a magic crystal for him, not letting him know that this crystal is the only thing keeping a flying city afloat, forcing He-Man to choose between capturing him or saving this city. But Skeletor is at his worst in the final two issues, when Prince Adam is teleported 30 years into the future. Without He-Man to oppose him, Skeletor conquers Eternia. Skeletor becomes a tyrant who rules with an iron fist, Skeletor has murdered Man-At-Arms, trapped the Sorceress in a crystal prison and has imprisoned anyone who defies him, including King Randor and Queen Marlena, into labor camps where they are worked to death. Skeletor has also caused massive famine and is sending the children of Eternia to reeducation camps where they are brainwashed into becoming his slaves. Adam teams up with the rebellion against Skeletor but is quickly captured by Skeletor. Skeletor plans to kill Adam and the rebels in front of all Eternia, to crush the people's last remaining hope of ever being free of his rule.

Masters of the Universe Classics minicomics, by Dark Horse Comics and DC Comics

• Gorpo is a former member of the overlords of Trolla, who has gone rogue due to his desire to rule the universe alone. After being banished to the Unnamed Dimension, Gorpo uses the alias of the "Unnamed One" to take control of the Snake Men and attempt to use them to free himself. After King Hssss and his Snake Men were defeated before they could free him, Gorpo uses the opportunity to free himself during a Horde attack on Eternia. Immediately tasking his minions to locate the ancient Sword of Power, Gorpo frees King Hssss from his banishment, only to kill him for his failure. As he acquires the magical tablet, Gorpo splits the whole planet of Eternia in half, which would have destroyed it, if not for the actions of the most powerful magic users of Eternia.

He-Man and the Masters of the Universe (2012-2016, by DC Comics)

• Skeletor is the Arch-Enemy of the Masters of the Universe and the most personal foe they face throughout the entire story. Originally a half-Gar bastard son of King Miro named Keldor, he developed a lust for power due to not being able to ever becoming a king. Making a deal with the monstrous entity Hordak, Skeletor started a civil war within the kingdom, leading to a countless deaths, before he kidnapped his infant niece and gave her to Hordak, who then began corrupting her. Responsible for the deaths of thousands while under Hordak's command, Skeletor eventually abandons him to pursue his own ambitions. With no care for anyone but himself, Skeletor regularly abuses his own minions and tries to betray his masters. Tricking She-Ra in to restoring him and revealing him location of millions of souls that Hordak tortured, Skeletor uses them to kill Hordak and create a weapon that he uses to destroy dozens of planets and their populations, later intending to use it to annihilate everything that has ever existed across every dimension and rebuild the multiverse and rule over it as a god of death and evil.
• Hordak himself is an ancient "space vampire" and the root of all evil in the story. Once a member of a heavily-populated race, Hordak tricked his enemies, and his own people, into massacring each other in a huge war, at which point he absorbed their souls into himself, leaving them in tortured agony. Using his victims' corpses as his army, Hordak tried to take over Eternia before being banished into an alternate dimension, which he quickly took over as his own, and then used to enter the realm of Etheria, where he slowly slaughtered and devoured the souls of billions. Using Skeletor to kidnap Adora, sister of Prince Adam, while she was an infant, Hordak corrupted her into becoming his killing machine. When she gave him access back to Eternia, which he invaded immediately, Hordak threw her aside since she had served her purpose. After dominating Eternia and regularly gorging on the souls of hundreds of citizens, Hordak destroys the planet Primus to show his newfound power and reveals his plan to dominate the entire universe and turn it into a nightmarish realm where he is worshiped as a god while all those who oppose him suffer horribly.
• King Hssss, an ancient ruler of the Snake Men, was in control of Eternia a thousand years before the arrival of Man. Desiring to become greater than his god Serpos, Hssss attempted to absorb the power of the core of Eternia. As a result, he and his Snake Men were punished, with him being the only survivor. Plotting to take control of Eternia once again, King Hssss wears the faces of many people during Eternia history, setting in motion plan to resurrect the Snake Men and raze the whole of Eternia until it becomes his domain. Possessing a leader of the Gar, Hssss tricks them into committing a coup against King Grayskull, killing him, his wife and countless men, women, and children, and then setting the whole capital on fire. Because of his manipulations, the Gar ended up being banished to their home island, suffering the hatred of whole Eternia and being reduced to cowardly backstabbers. Killing and wearing the skin of King Randor, Hssss tricked Masters of the Universe into coming to the Underworld, where he planned to use He-Man to resurrect his Snake Men and absorb the power of Eternia. When that fails, he ends up possessing Prince Adam himself, and when Adam takes back control over his body and kills him, King Hssss destroyed his own species out of spite, leaving Eternians without an army to reclaim their world.

Crossovers

• Injustice: Gods Among Us & Injustice vs. Masters of the Universe: Darkseid is the despotic ruler of the planet Apokolips and one of the most sworn and powerful enemies of Superman. Torturing Black Racer into submission, Darkseid allows his son Kalibak to lead an assault on Earth, killing tens of thousands of people, before his army was destroyed by Superman. Angered at the fact that Superman sullied his reputation by killing Kalibak, Darkseid starts scheming the destruction of Superman more aggressively, first hiring Lobo to take him down and then, when that failed, joining the conspiracy with Ares and Hera, manipulating humans, superheroes, and Olympians into a bloody conflict, with the human government even launching nukes as a result. After this, Darkseid found the weakened Skeletor in the cosmos, and from him, he found the location of the solution to Anti-Life Equation to be in Castle Grayskull. Invading Eternia, Darkseid kills, captures and transforms thousands of people into his obedient slaves, as he tries to uncover Anti-Life Equation, to take control of the multiverse, killing the minds and personalities of every living being aside from himself.
• He-Man/ThunderCats & Injustice vs. Masters of the Universe: Skeletor and Mumm-Ra are the evil supernatural beings who decided to unite in order to destroy their sworn enemies and take over all reality. Enslaving the Ancient Spirits of Evil, thus giving them the form of titanic beasts, the two command them to cause chaos all over Eternia in order to take possession of two ancient magic swords, the Sword of Omens and the Sword of Power. As a result, thousands of Eternians were killed, and nearly all Eternia was on the brink of destruction. When the remaining forces of Eternia and the ThunderCats managed to defeat their beasts, Skeletor and Mumm-Ra fused into the extremely powerful Mumm-Ator and, after destroying the remaining opposition, break into Castle Grayskull to try to take over the multiverse. After Lion-O and He-Man combined their power to separate and banish them, the weakened Skeletor pretends to serve both Darkseid and the power-mad Superman, manipulating them both, causing Darkseid to invade Eternia, an action which resulted in many more people being killed or brainwashed to be servants of Darkseid.

Western Animation

• Skeletor, formerly known as Keldor, is the main antagonist for most of the series and the would-be conqueror of Eternia. Destroying the wall that separates the Dark and Light Hemispheres of Eternia, thus setting himself free, Skeletor continues his quest to conquer Eternia. Plotting various schemes, Skeletor does whatever he can to get more power, such as instigating a war between the Andreenids and the Avions, just to get a free access to the Andreenids' supply of Ambrosia, razing villages and trying to take away Eternium—the strongest metal on Eternia, vital to Kulataks' survival—from Kulataks. Regularly abusing his Evil Warriors, Skeletor at one point tried to sacrifice his minion Evil-Lyn to eldritch horrors in exchange for their service.
• Webstor is a spider-like creature who works for anyone who pays. Becoming one of the members of the Council of Evil, Webstor assists Skeletor in capturing the Masters of the Universe and helped him attempt to breach Castle Grayskull, before departing from him after they failed. Deciding to work for himself, Webstor sneaks to the Andreenids' supply of Ambrosia, where he eats it and mutates, obtaining more power. Kidnapping a large portion of Andreenids and Avions, Webstor plans to feed them to his deadly spiders, before going on to terrorize the whole of Eternia.
• King Hiss is an ancient ruler of the Snake Men, who was on the verge of conquering Eternia, feeding on many innocents and desiring to destroy whole civilizations to keep himself at the top. After being banished to the Void by the Elders and Zodac, he was freed by the combined effort of a descendant of the Snake Men Kobra Khan and Evil-Lyn, King Hiss wasted no time trying to eat them later, only stopping when the latter promises to help him obtain Power of the Elders. Wanting to be at the top of a food chain again, King Hiss plots various schemes, while eating more and more innocent creatures alive. First, he tries to turn every person into a Snake Man who he can control, and when that fails, he tries to set his god Serpos free to cause destruction upon Eternia, planning to "cleanse" the land, with the survivors becoming either slaves or food.