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  • 009-1 anime's first episode: Ivan Godunov is the ruthless deputy chief of security of the Eastern Block. Kidnapping a scientist, Godunov tortures him for information on his new weapon, later murdering him after he has what he needs. When the 009 corps is sent after him, it is revealed Godunov intends to use nuclear weapons on the Western Bloc, killing countless people to ignite a bloody, genocidal war where he can come out on top.
  • 17-sai., by Seiji Fujii and Youji Kamata: Miyamoto is a vicious, brutal thug of a teenager who uses his ties to the Yakuza to get away with any violent impulse that he wishes. Though starting out simply assaulting and nearly killing people for their cash or just for fun, Miyamoto soon escalates his depravity until the point that he kidnaps the teenage girl Sachiko and holds her hostage in his house for 12 days. Regularly raping and beating the girl while keeping her starved and dehydrated, Miyamoto allows other gangs to rape the girl in exchange for their loyalty, and later sets parts of Sachiko's body aflame when she tries to escape. After beating one of his friends to death for being clumsy, Miyamoto tries to murder Sachiko and her twin sister with a baseball bat to eliminate all evidence of his crimes, and, even when caught, Miyamoto expresses zero remorse for his crimes, cracking a smug grin upon learning Sachiko has recovered from his torment simply because he now cannot receive the death penalty.
  • 91 Days: Fango is the psychotic enforcer of the Orco Family who introduces himself by beating Tigre to near-death, then causing a shootout in a bar. Later Fango has a teenage boy killed and shoots right through a prostitute to kill Avilio Bruno, who was hired to kill him. When Don Orco refuses to declare war on the Vanettis for putting a hit on him, Fango stabs one of Orco's men with a fork and works with Avilio and Nero to overthrow Orco, ending with him killing Orco and feeding him to his men. Taking over Orco's crime syndicate, Fango starts a gang war which kills countless people, and nearly kills the wife and daughter of prohibition agent Murphy to force him to back down. Fango also forces Corteo to make his booze for him only to sell Corteo out to be killed by Vanettis after Fango got Corteo's recipe from a prohibition agent he killed; Fango also intends to betray the Vanettis.
  • 20th Century Boys: Both versions of Friend were absolute monsters of different varieties.
    • The first Friend—Fukubei Hattori— grew up ignored by his classmates, with their attention often focused on hero Kenji Endō. Thus, Fukubei developed a craving for attention, and a disproportionate hatred for Kenji. Already wicked as a child, Fukubei psychologically abused his so-called "best friends," regularly tried to terrify people with his tricks, and ruined the childhood of one of his classmates—who would later become the second Friend thanks in part to the Fukubei's cruelty. Forming the "Friendship Party" as an adult, Fukubei began developing a virus that painfully killed anyone it infected, all while silencing anyone who got his way. Unleashing the virus, Fukubei framed Kenji and his group for the ensuing 150,000 deaths, took over much of the world as a "hero", and ruled it with an iron fist, sending people to reeducation camps for even minor crimes. Fukubei's master plan is then revealed: Use a new virus to wipe out 99% of the human race, then rule over the remaining 1% of "true believers". Sociopathic, egomanical, and petty, Fukubei Hattori set the bar for wickedness in this manga.
    • The second Friend—Katsumatagrew up unliked and bullied, in particular by Fukubei, and this resulted in a hatred for all humanity. Taking over after Fukubei's death, Katsumata destroys much of human civilization with a new virus and rules what's left even harsher than Fukubei, spreading tales of "aliens" invading to keep innocents terrified in the process. To further cause chaos, Katsumata regularly sends out small doses of vaccines to groups of potential rebels, knowing they will tear themselves apart trying to acquire the antidote. Revealing he plans to destroy all of humanity with an incurable virus, Katsumata tries to make Kenji watch as he kills Kenji's niece, Kanna—Kanna's mother is Kenji's sister, while her father is Fukubei—as revenge for a transgression Kenji committed against him as a child, and, when finally defeated, it is revealed he left an Anti-Proton bomb to be detonated by his followers, which will destroy the entire world when activated.
  • Absolute Duo: Narukami Sakaki pretended to befriend Toru Kokonoe so as to gain entry into Toru's family sword-training dojo. Once inside, he casually murders everybody inside before setting the building on fire, while mocking his victims as "being weak." Next Sakaki turns his sword on Toru, which Toru only survives because his grievously wounded younger sister, Otoha, took the blow instead. Narukami then mocks the Heroic Sacrifice by saying "how boring, all she did was die." Some time later, Narukami does something similar to a boy who would later be named "K," killing the latter's older brother before him resulting in his family being torn apart, and him being sold into a criminal organization that made him a combination slave/test subject/Child Soldier, and when "K" wound up in prison after attacking Toru at Koryou Academy, Narukami teleported him out and sliced him in half, vertically, letting him live just long enough to tell him that his life was meaningless and his role in the story is over. When Toru returns home on a yearly pilgrimage to honor the dead, starting with his sister at the cemetery, he finds Narukami waiting for him at the site of his former dojo, acting as if nothing's wrong, like he doesn't understand why Toru's angry. After trying to make Toru sound crazy for wanting to avenge his fallen loved ones, Narukami gets bored and slices Toru's shield in half—along with the arm behind it.
  • Acid Town has these two pedophile rapists:
    • Ashiei is a member of the Yakuza, like many characters in this manga, but what distinguishes him is the fact that he raped his stepson Yuki and sold him into being a Sex Slave when Yuki was only 12. Years later, he shows up again, stalking his stepson. When a friend of Yuki's tracks him down to confront him, Ashiei brags about his stepson's "talents" as a slave and about raping him. He reveals that he's stalking Yuki out of revenge for being left with burns from a fire that Yuki set to escape him, because his looks were ruined and he's in pain, despite the fact that Yuki showed mercy by not killing him. When he finds out Yuki is still alive during their confrontation, he gloats about how he wants to rape him again, and tries to do so until Yuki escapes. He was a Stalker with a Crush on Yuki's mother, took the opportunity when her husband died, possibly raped her as well, and was a factor in her suicide. He's unable to work with pretty much any gang other than Wang's triad, because of his behavior that ranges from unstable at best to purely sociopathic. Even the other Yakuza reject him.
    • Wang shows up upon the scene of Ashiei and Yuki fighting years later. He reveals himself to be a False Friend of Ashiei's, offers Yuki a loaded gun to finish him off, then, when Yuki hesitates, shoots Ashiei himself. However, it turns out he was the slaveholder/pimp that bought Yuki from Ashiei. He is an owner/seller of child prostitutes. He didn’t help his former victim out of any noble cause, but instead wants Yuki, now seventeen-years-old, for himself as his personal "pet," as well as using him as The Mole against an opposing mob boss that's actually treating Yuki with some degree of respect and caring. By kidnapping Yuki and holding him hostage, along with his previous actions to consolidate power, he's also managed to turn the heat up on a Mob War that had grown somewhat cold after the first round of deaths.
  • Agent Aika: Rudolf Hagen created the Delmo for one purpose: to serve as his own personal harem after the apocalypse. An egomaniac who views himself as the pinnacle of perfection, Hagen abducts and brainwashes women he deems worthy to join the Delmo. Researching the volatile material called the Lagu, Hagen intends to use it to cause a chain reaction on earth to exterminate all life, allowing him to repopulate the world with the Delmo, creating a new race with his "superior genes". Not even Hagen's own sister and lover Nina is safe, as Hagen happily attempts to sacrifice her when he judges her usefulness to him is done.
  • Air Bound, by Shirogumi: Winston the White Weasel is the bloodthirsty leader of the weasels. Reveling in the fear he instills in his victims, Winston led wave after wave of assaults on Dream Island, one of which involved massacring several of the island's seagulls and crushing the eggs. Under the guise of inviting the Dream Island mice to a peaceful celebration, Winston hypnotizes the mice into walking towards the water, fully intent on devouring them all when they crossed over. After coldly murdering the leader of the Dream Island mice, Winston corners the remaining mice in the water, giddily admitting that he hadn't thoroughly enjoyed himself since he was a child. Refusing to take his defeat gracefully, Winston tries to drag Gavin into the depths of the ocean when the tide returned.
  • Air Gear: Sora Takeuchi emotionally abused his brother Nike and his girlfriend, the two people who loved him and trusted him most. He even brainwashed the latter, and when they stopped being useful to him, he threw them aside like trash. While he does have a slightly sympathetic past that paints him as a failure, this justification rings hollow when it's shown that he's orders of magnitude more powerful than every single rider except Ikki. Furthermore, he remorselessly killed several friends who were once in the same situation as him and who even helped him, all in the name of gaining personal power. He is either directly or indirectly responsible for all of the deaths in the series and he doesn't even think highly enough of the lives he's taken to feel something like satisfaction, let alone remorse or regret. After he is defeated, he spits in the face of redemption and tries to turn his girlfriend into a bomb so that he could kill everyone in the tower in which he was fighting so that even if he were to lose, his opponents wouldn't win. He only gave up afterwards when faced with overwhelming power that convinced him he would never be able to succeed. Even Nike looks tame and compassionate in comparison.
  • Ajin: The anime version of Ajin Satō, real name Samuel T. O'Brian, is a former member of the US special forces discharged for insubordination. Learning of his immortality in Japan, he plans to plunge Japan into terror while falsely claiming to work for Ajin liberation. Forming an Ajin terrorist ring through manipulation and treachery, his attacks include toppling a building into a heavily manned company headquarters, going in with said building and killing his way out of responding police units, and assassinating 15 government and corporation officials, and all the while killing everyone in his way. In his final attack, he steals 20 units of nerve gas, takes over a JSDF base, arms the gas on missiles, and demands the Japanese government to submit Japan to his rule within one week or else he will exterminate Japan and rule over the remains. When the government compromises some islands for Ajin governance, Satō rejects the offer as "boring" and prematurely fires a missile at the Prime Minister's office, killing an untold number of people in a massive radius, shocking even his subordinates and causing many to defect. Along the way, Satō had formed a grudge with Ajin Nagai Kei, always preparing to decapitate Kei and murder people Kei had cared about in front of his eyes.
  • Akame ga Kill!:
    • Prime Minister Honest is the self-indulgent de facto ruler of The Empire, manipulating their young Emperor to maintain his hedonistic lifestyle. Regularly ordering the execution and torture of innocents, Honest uses his position to sexually assault women as he pleases and terrorizes his population with his military, allowing his twisted son Syura to form Wild Hunt to rape, torture and kill as they please. Launching devastating campaigns to secure his grip of power, when the capital is attacked by rebel forces, Honest convinces the Emperor to activate the Supreme Teigu, risking the city's entire population just to avoid giving up power. Having poisoned the previous Emperor to stay in power, Honest's only hope is that his twisted corruption lives on even after he dies through the current Emperor and when beaten, cowardly flees for his life.
    • Syura, Honest's equally-sadistic son, is the leader of Wild Hunt who hopes to outdo his father in evil. Taking his band of psychopaths to indulge in the same depravities of himself, Syura sees attacks where innocents are butchered and women and children raped before being slaughtered, even having a mother and her daughter violated and killed atop her soldier-husband's grave. Capturing a member of Night Raid, Syura horrifically tortures him for information, enjoying every moment of doing so.
    • Champ is a pedophile, Serial Killer and rapist, and the most depraved member of Wild Hunt alongside Syura. Murdering a woman for trying to stop him from raping a young boy during one of Wild Hunt's raids, Champ goes on to force himself on the young daughter of a dead Imperial soldier before killing her. When confronted by the former teacher of a classroom full of children he had raped and murdered, Champ struggles to recall the event due to the sheer volume of his victims.
    • Zero: "Uncle Bill", real name unknown, is the leader of the Empire's assassination squad, Group of Terror. Using the children that weren't skilled enough to be part of the Elite Seven, Bill uses drugs to enhance their skills in a painful process that also includes indoctrination into absolute loyalty. Training children with inhuman methods that weren't far from tortures, including leaving them without needed drugs as punishment, Bill didn't care if they died during missions, and even "euthanized" one of them after considering her the weak link of the team. A cold man that doomed many children to painful lives, including Akame's sister Kurome, Bill's "training" affected her for years.
  • Akashic Records of Bastard Magic Instructor: Former Imperial Court Mage Guard Jatice Lowfan was stripped of his position for using Angel's Dust—a drug which horrifically turned its user into an easily controlled, zombie-like creature—to control innocents into assassinating rivals in the Imperial Court Corps and nobles. Discovered by Glenn Radars, Jatice has his puppets murder Glenn's only friend out of spite, which he later taunts him about. Murdering a man, Jatice takes his identity and coerces Glenn's student Sistine into marrying him, while continuing to taunt Glenn.
  • Akudama Drive: In a World... of Grey-and-Gray Morality and filled with violent criminals, two stand far above in terms of their sheer vileness:
    • Doctor makes a habit of finding people who need medical aid and brutally dissecting them alive, killing any civilians around the area who bother her during her work. Upon being hired for a heist job, Doctor sabotages the stitches of her injured teammate Brawler so that his wound would reopen, causing Brawler to die from blood loss just because he was immune to her drugs. Doctor later sells out the team to the Executioners in order to have her status as an Akudama cleared. Despite having a clean slate, Doctor wastes no time in continuing her criminal ways, slaughtering a group of lab workers so that she can analyze the blood of the immortal Brother and Sister. She later forces Hoodlum to aid her in her goal to kidnap and dissect the two children so that she can discover how to have full control over death.
    • Cutthroat is an eccentric Serial Killer who beheaded over 1,000 victims. After being rescued from his execution by the team, Cutthroat develops an obsession with Swindler, acting as her bodyguard solely so that he can kill her for himself later on. After the team gets split up, Cutthroat heads towards the Kansai region to find Swindler, killing every person he comes across along the way. Upon reaching Kansai, Cutthroat invades the Executioners' headquarters and slaughters hundreds of workers to form a pile of their corpses to greet Swindler with. When he chases her down to a storage closet, Cutthroat attempts to slowly strangle her to death, taking glee at her agony.
  • Alderamin on the Sky: Lt. General Tamutsukusuku Safida is the top commander of the Northern Border Regiment with a devious scheme for glory. An incompetent general who's looked down upon, Safida intends to start a war with the Shinark tribe, a ethnic group of civilians, both out of personal disdain and to look like a victorious general. To that end, he imposed poor conditions to the Shinark tribe, leaving them in great poverty and stealing their spirits, considered sacred to them. Once the Shinark tribe retaliates in a bloody crusade, Safida showed no mercy, burning their villages and trying to have all of them killed, including innocent bystanders. He even abused his authority, sending soldiers without a care to near certain death, resulting in thousands of casualties. When the Shinark tribe's main village was taken over, Safida allowed his men to Rape, Pillage, and Burn it while glorifying himself. Once he's charged for his crime by the royal court, Safida tried to throw his own followers under the bus to save himself, knowing it will result to the death penalty.
  • Altered Carbon: Resleeved: Tanaseda Sr., the founder of the Mizumoto Syndicate, developed the Mizumoto system while supposedly sacrificing his life for his successors. In truth, Tanaseda has his own personality overwrite his supposed successors, killing them and allowing him to take on their identity, with his first victim being his own son. Holding the tattoo artist Holly's parents hostage to get her to perform the transfer, Tanaseda later destroys their Stacks to murder them, and when exposed, attempts to slaughter his Syndicate and simply start over.
  • Amalgam of Distortion: Sara Warren, SAI's head scientist, experiments on countless people, turning them into horrific monstrosities to sell on the black market, even eating one alive. Becoming obsessed with high-schooler Rokumichi Kusaba, Sara creates a lifelike hologram of a child to jump on a train track, forcing Rokumichi to risk his own life to save the fake child. When Rokumichi escapes her laboratory, Sara sends her other experiments to hunt him down while kidnapping his Love Interest, Yayoi Hina. Sara is also revealed to have manipulated one of her follower's memories to make him think she was his savior from the harm she had put him in, and also manipulates another young man into becoming a Serial Killer. Ever obsessed with her own god complex, Sara also subjected her own unborn children the same procedures as Rokumichi, hoping to create a race of immortal being while turning the other five billion people on the planet into more monsters. Beautiful and sadistic, Sara cements herself as Rokumichi's most dangerous enemy.
  • Amon Saga: Tsuki no Miko: Momotarō, aka Yotendoji, is the eldest child of the demonic Princess Kaguya. Having taken over a large base of operations, Momotaro terrorizes the populace and betrays one of his old allies by selling out his clan's location to fearful humans, resulting in the shapeshifters being almost exterminated. Momotaro frequently enjoys the taste of human flesh, having women cooked and fed to him. When he discovers an arrowhead in one meal, he proceeds to force-feed it to the cook before crushing her head. Upon hearing of Kaguya's arrival, Momotaro goes to a village and eats a noblewoman alive to "sample" the goods for a feast. Upon finding her too oily, he orders all the children abducted and cooked for the feast, killing any who try to stop him.
  • Anatolia Story: Zuwa is a feared enforcer of Queen Nakia for his method of skinning victims alive for the slightest offense. Using the skins he takes as materials for his clothes and accessories, Zuwa's favorite targets are children and "exotic" people seen as rare material, desiring to do the same with Yuri. In charge of capturing her, Zuwa even went as far as to murder the child Tito for defending her and helped frame Yuri for his to his sisters to plot an assassination attempt with them. Having enough of Yuri escaping his constant attempts on her life, Zuwa went on a rampage, killing a number of solders in a final attempt to kill Yuri.
  • Angel Cop:
    • Governor Maisaka of Tokyo is the true Big Bad of the series. Seeking to get rich, Maisaka forms the Red May terrorist group and has them bomb Japan's infrastructure and civilians, killing innocent people by the truckload, before creating the monstrous Hunters to slaughter their way through the terrorists and many civilians. When the special forces begin investigating, Maisaka has the Hunters attempt to exterminate them, even torturing one horribly to keep his plan to use nukes against manufactured enemies secret, all so he can grow richer.
    • Lucifer is the leader of the Hunters, a group of psychics out to stop terrorism. A self-righteous sadist, Lucifer doesn't care who stands in her way, viewing everyone who tries to stop her brutal murders as an accomplice to the Red May. When Hacker and Peace take Tachihara with them, Lucifer tortures a scientist for information, causes a massive pile-up on a highway, and kills Peace in front of Hacker to torment him. When Asura and Freya refuse to partake in her murders, Lucifer labels them as traitors and kills Freya. Participating in an attack at the Special Forces base, she kills Ichihara and Asura before trying to drain Raiden of his energy.
  • Angels of Death: Catherine "Cathy" Ward, the B3 floor master, was once a manipulative girl who strung Lucy into killing her school rivals, before growing up to become a sadistic prison warden who punished the "sinners" under her charge, forcing Lucy into helping her, later killing Lucy herself. Helping Danny Dickens recruit killers for the Tower, when Ray Gardner and Zack Foster encounter her, Cathy tortures both of them, and also makes Zack relive traumatizing memories from his past, before drugging him to force him to kill Ray. Additionally, Cathy keeps several Tower prisoners withered and trapped to enjoy their unending pain.
  • Anti-Magic Academy: The 35th Test Platoon: Haunted is a monstrous psychopath obsessed with spreading despair to all around him, and serves as the Arch-Enemy of numerous characters due to his evil. Introduced butchering and sacrificing over 50 people to summon a demon and have it slaughter innocents, Haunted later invades one of the Inquisition's schools and murders his way through dozens of trainee students. In his quest to cause despair to everyone he sees fit, Haunted murders one of his partners in the arms of her sister, reunites a lost girl with her mother only to decapitate the girl while her mother watches, and forces Mari to serve him by using numerous orphans as hostages, then revealing he killed the children long ago. In his grandest scheme of despair yet, primarily targeting his self-proclaimed greatest foe Takeru, Haunted turns the boy's sister into a killing machine, knowing Takeru will either have to kill her or watch her slaughter humanity, and occupies his time by wiping out an entire town of innocents. In the end, Haunted is beaten after revealing he has killed close to 13,000 people over the years, and uses his final moments in an attempt to kill Takeru to snuff out the "beacon of hope" that the world sees him as. A truly depraved lunatic who horrified and repulsed even his own organization and partners—many whom he kills at the drop of a hat—Haunted stands out even in this dark world as a twisted individual.
  • Appare-Ranman!: Gil T. Cigar, better known as Gil The Butcher, disguises himself as racer Richard Riesman while hired to sabotage the big race. Murdering his employer when he grows sick of taking orders, Gil proceeds to try to slaughter everyone about before kidnapping a woman named Sophia and several others, threatening to have Sophia gang-raped by his men should she prove problematic. To amuse himself, Gil has two hostages given one gun with a promise to release who kills the other, even killing any of his subordinates who fail him after torturing them with multiple non-fatal gunshots. Plotting to send Sophia along in a train packed full of dynamite into Chicago station, Gil plans on a massive loss of life to brand his personal "Might Makes Right" philosophy into America.
  • Ar tonelico ~arpeggio manga: Masticus is a seemingly-kind scientist who aimed to non-humans like the Reyvateils, as he blamed them for two apocalyptic disasters in the past, despite humans playing a strong role. Unleashing the Reveris virus, causing Reyvateils to go berserk and comatose, Masticus plans to perfect it with the Hymn Crystal "Soporific", having Espada's parents killed to get it. Once Sonnet manages to retrieve it from Espada, Masticus began to show his true colors, revealing to Sonnet she's the latest version of the virus, transforming her into the perfect version of the virus and ordering her to kill her friends Espada and Adagio. Once Sonnet was able to break free, the virus manifests itself into a physical form, and under his command Masticus orders it to kill everyone. Once the virus is dealt with, he laughed at the heroes for their ideals before throwing himself to his death as one last attack. A hateful scientist, Masticus pretends he fights for humanity, but in actuality just wants to satisfy his discrimination.
  • AR∀GO: City of London Police's Special Crimes Investigator: The Patchman is a vicious serial killer initially dubbed "this era's Jack the Ripper" for his depraved and random murders. The Patchman murdered Arago's parents and later his brother Ewan in the future. The Patchman is later revealed to kill people so he can take pieces of them to keep his own rotting body mobile. He is also responsible for empowering his servants, the Four Horsemen, after taking advantage of their pain and despair to enlist them in ending the world and destroying humanity. He reanimates Ewan as a corpse with his consciousness trapped in his mind to mess with Arago, and at the final battle he possesses Ewan so Arago can know the despair of his own brother killing him.
  • Area D: Ango Agatha, the true villain of the series, is the first to come out as a superpowered "Altered". A brilliant quantum physicist analyzing the effects of the Altereds on the world, Agatha began to conduct horrific experiments on innocent Altereds that resulted in many being tortured, killed or enslaved. Series hero Jin Kazaragi and his brother Rei escaped Agatha as children, only for Agatha to later manipulate Rei as his pawn to begin awakening Altereds which resulted in massive explosions that killed thousands, culminating in the Lotus Flower Incident that killed 8,000 civilians. Later having Rei form the Ubermenschen Union, Agatha orchestrates many more deaths via his attack squads or bombing campaigns while pitting Rei against his brother. Finally, Agatha reveals he intends to control the path of evolution, seeking to recreate the incident that created the Altereds which will kill all but .02 percent of humanity.
  • Arifureta: From Commonplace to World's Strongest: Ehitorujue is the god who rules Tortus. Slowly growing bored and lonely due to his immortal life, Ehito develops a cruel and sadistic personality after seeing his people suffering. To that end, Ehito manipulated several races to fight brutal wars and has his worshippers commit countless atrocities. Attempting to manifest himself in Tortus, Ehito attempts to bodyjack a powerful Vampire Princess, Yue. When that failed, he then set his sights towards a highschool student who has a misguided sense of justice which resulted on him and his classmates being summoned into another world. After Yue was released from her seal, Ehit successfully possessed Yue while torturing her inside out. After being expelled from Yue's body, he absorbs all of his creations in order to finish the heroes once and for all. It was soon revealed that Ehit's master plan was to destroy Tortus and attempts to find a new sandbox to play with in other worlds solely to satiate his boredom.
  • Armored Trooper VOTOMS: Colonel Yoran Pailsen is a ruthless Mad Scientist who crafted an experiment on the world of Sunsa that involved burning hundreds of children alive to determine who had a unique "survivalist" trait. Obsessed with creating the "perfect soldier", Pailsen directs his private unit, the Red Shoulder Battalion, to commit wartime atrocities and even fight to the death among themselves. In order to test his theories, Pailsen even manipulates the head of the military, Fedok Wockam, into starting a pointless battle that leaves 120 million people dead, obsessed with furthering his research no matter the human cost.
  • Artificial Maiden: Kai is a 240-year-old alchemist who runs a business that specializes in cloning. Kai places the clones in a virtual paradise before harvesting their bodies for his clients. Realizing that his assistant had given a clone of Satonaka to a married couple, he murders him, and sends the Crow to retrieve the body; the Crow murders Musumi's parents, and reduces him to a brain. Learning that Musumi was still alive, he kidnaps him, and implants a parasitic plant inside Nakahara, stating that she would die if her brain isn't transferred to a clone's body. An apathetic man, Kai isn't above murdering his own Jinzous if they were to inconvenience him, and not even Satonaka is immune to his wrath; he tricks Satonaka into releasing him from a trap by appealing to his sensitive nature, only to stab him to death. Desiring only to make a profit, Kai cares nothing on the effect his illegal acts have on those whose lives he creates.
  • Assassination Classroom:
    • Shiro, real name Kotaro Yanigasawa, was a Mad Scientist focused on utilizing anti-matter in a human body, and the reason Koro-sensei may destroy the world. To this end, he used the famed assassin the God Of Death as a human guinea pig in painful experiments, using his own fiancée as their liaison since Yanagisawa figured she was worthless as a hostage. When the God of Death escaped, destroyed the lab and took Yanigasawa's eye, the scientist formed the identity of Shiro and plotted his vengeance. He implanted a boy named Itona with the same tentacles and later abandoned him to die when he'd served his purpose. Mutating the assassin's former protege into a monstrosity, he tested his new success by having him annihilate a giant building—and anybody inside—before attacking Koro-sensei and his students. Having the second God of Death attack Koro-sensei, Yanagisawa opted to then have the students attacked, gloating how he'd kill every single one of them painfully and Korosensei would be forced to watch his class die before dying in despair. When his former fiancée's sister attempted to help Korosensei, Yanagisawa had her impaled through the chest and gloated how he'd intended to use her as a "replacement" for her sister.
    • Akira Takaoka is a brutal military trainer known for torturing his students with sadistic relish while he breaks them mentally. During his brief stint as Class E's trainer, he is willing to brutalize any unruly student, regardless of gender. After being ousted, Takaoka devotes himself to revenge. After stealing money to buy a bio-weapon and hire hitmen, he infects Class E with a virus to cause a horrifyingly painful death as they slowly suffocate under the weight of tumors. The few students who escape this fate are targeted for even worse fates as Takaoka intends on burying a girl named Kayano alive in cement in a bathtub full of material lethal to the kids' teacher Korosensei, which would force him to sacrifice his life to save her. To drive in his victory, he even destroys the antidote while gloating he might use the money to purchase middle-school aged kids to murder on a regular basis as some twisted celebration.
  • The Asterisk War anime: Gustave Malraux is a former member of a terrorist organization of Asterisk that in the past carried out the "Jade Twilight" plan. Hired by Nicolas Enfield to stop his daughter, Claudia, from participating in a tournament known as Gryps Festa, Gustave wasted no time attacking Claudia's best friends, Ayato and Julis, with his chimera when they visited the capital city of Julis's home country, Lieseltania, resulting in Julis tighten up the security. Returning in Episode 24, Gustave sends his chimera to attack the capital city in order to distract the police forces, and plans to attack the orphanage in order to lure the heroes out. After he successfully lures them out, he then attacks them with his hydra, leaving the hydra to cause destruction in the poor district of Lieseltania's capital city.
  • Attack on Titan:
    • Sergeant Major Gross of the Kingdom of Marley military forces is introduced in a flashback when he catches young Eldians Grisha and Fay Yeager trying to see the airships at a field. Ordering Grisha savagely beaten, Gross leaves to take the eight-year-old Fay home, but instead feeds her to his dogs while she's alive and makes his own sons watch. Years later, Gross is in charge of turning the Eldians into mindless, man-eating Titans while releasing one man to be chased and ultimately devoured by his former comrades. Mocking Grisha himself for being Eldian, Gross states his reason for his actions is his desire to exterminate all Eldians and his belief that such cruelty is simply "fun". He then proceeds to turn the last of Grisha's comrades into a small Titan just for the fun of seeing Grisha and the Titan fight before Grisha is devoured.
    • The first King of Eldia and the mythical Devil of All Earth, King Fritz, as shown in Chapter 122 "To You, 2,000 Years Ago", was a cruel tyrant who ran an empire on conquest, with countless slaves endlessly abused out of their very sense of self, many having tongues removed. When the young slave Ymir was accused of freeing pigs, the King tried to have her hunted for sport, whereupon she found the power of the Titan. Using her to exterminate and kill all in his path, the King raped her to produce children to inherit her power and upon her death, forced his daughters to eat her corpse raw, unleashing the new Titans on all his enemies to found an empire on genocide and blood.
  • Aura Battler Dunbine: Lady Luuza Luft manipulates her powerful husband, Lord Drake Luft, so she can conquer Byston Well. Encouraging Drake's war, Luuza cares nothing for the people massacred, as long as it secures her power. Angered by her daughter, Riml, attempting to stop the war, Luuza has her beaten and imprisoned, later threatening Riml's life to make a group of rebels back down. Believing King Bishott Hale to be a better puppet than Drake, Luuza cheats on her husband with the king. When Drake becomes aware of Luuza's treachery, he sends Riml to arrest her, only for Luuza to murder her daughter in cold blood.
  • Azumi:
    • Bishamonten, named after the Japanese War God, is the leader of the "nobuseri," or masterless samurai-turned-bandits who have taken to preying on the populace. Occupying a post town, Bishamonten massacres whoever stands against him and makes the town his personal kingdom where women are regularly raped or kept as sex slaves for him and his men. One son of a former samurai, who attempts to kill Bishamonten for raping his sister, is easily disabled by Bishamonten, who then thanks the man for his sister's body before killing him and having his corpse defiled. Kidnapping high-ranking officials in the province, Bishamonten uses them as hostages after slaughtering most of the province's military, and has said hostages dropped onto sharpened bamboo stakes later. When he captures Azumi's comrade, a transsexual woman named Kiku, upon discovering Kiku is biologically male, Bishamonten breaks his word to not harm Kiku by allowing one of his lieutenants, Seiryu, to rape and beat Kiku to death.
    • Konishi Shizune and Tadane are a pair of psychotic twins who pose as a single "Shizune" in a small province. Pretending to be a devout Christian and the son of God, Shizune slowly manipulates the land's new administrator, the peasants and the samurai, laying the groundwork for a brutal war between them. When tensions are high, he then gives a speech to the peasants to declare the conflict a "holy war" that God himself has decreed. The twins proceed to drug Azumi herself, keeping her captive in their home where they torture her, starve her and deprive her of sleep to break her mind and make her their new servant, while also involving their old nursemaid Naka in the "games" as well, by forcing Azumi to choose between eating or sleeping and Naka's life. The twins proceed to enjoy the bloody war they have created while planning to have the noncombatants take refuge in a mine before trapping them there and burning them all alive. When a young woman whose family has been killed in the conflict offers herself to one of the twins, he proceeds to torture her to death while mocking her. Hiding their utter depravity behind a veil of gentle serenity, Shizune and Tadane end up being two of Azumi's most vile and deeply personal enemies.
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    B - C 
  • B: The Beginning: Gilbert Ross is the coroner for the Royal Investigation Service, and a Serial Killer who proves that sometimes Humans Are the Real Monsters. In a flashback, Gilbert resents his father's growing sympathy for children being raised to be super soldiers in the Jaula Blanca Institute and kills him. Seeking to destroy his father's legacy, he lies to Minatsuki that he'd used as spare parts for Koku (one of two perfect progenitor clones). This lie led Minatsuki to betray the school and kill Heath Flick (Keith Flick's father and the headmaster of Jaula Blanca) as well as almost every child in the institute. After this, he goes to college with Keith and becomes obsessed with Keith's adoptive sister Erika. When he finds out she loves her adopted brother romantically, he vivisects and slices her into bits before tossing her remains over the mountain and framing a Reggie (a demihuman bred to kill) for the crime. He proceeds to kills 37 women who look similar to Erika, and covers up crimes committed by Market Maker (a corrupt Black Ops organization led by Minatsuki) to the point of having Jean Henry Richard brainwashed to attack Bran and then commit suicide in front of Keith. Eager to break Keith and make him stoop to his level of brutality, he lures Keith into the institute and mocks him over Erika's death. There, Gilbert reveals his involvement in the institute's destruction and Erika's death before he tries to kill Lily, forcing Keith to kill him.
  • Baccano!:
    • Lebreau Fermet Viralesque, another of the original immortals, was the caretaker of the immortal child Czeslaw Meyer. However, once they were immortal, Fermet revealed his true colors as a vicious sadist who tortured Czeslaw for years and years, with new, inventive ways, ranging from throwing him into a roaring fireplace, to making him bathe in acid. The excuse was to test the limits of immortality. The truth was simply sadism. Then we find out that he's the reason why SAMPLE, a cult whose members tortures children in the hope that the children will receive any pain directed at themselves, really spread across the world. He also killed Huey's wife Monica, giving Huey his Start of Darkness. To top it off, he sets things up so that Niki, a woman who loved him and who was a close friend of Huey and Elmer, would be killednote , and then tells Elmer and Huey that their bomb did it just to see the pain on their faces. He does all of this out of pure sadism and finds it fun. He's even more dangerous than Szilard, because as the latter may enjoy killing and devouring others, he at least doesn't kill without some sort of practical reason (even if that reason is simply because his victim has something he wants). Fermet will murder and betray everyone just for fun, even the people who love him. Especially the people who love him.
    • Szilard Quates, the immortal Mad Scientist and alchemist, believes in knowledge being the most important commodity in the world, and to that end devours immortals for their knowledge. After becoming immortal, Szilard devoured the brother of the immortals' leader before being driven away. Szilard creates Artificial Human homunculi to serve him, abusing them mentally and physically. He also developed his own immortal potion that he feeds to intelligent people before devouring them to amass their knowledge without working for it. He isn't above straight up murder for his purposes either. It's mentioned at one point he finds no greater joy than in devouring others.
  • Bakugan: These are the worst the Bakugan Battle Brawlers have had the displeasure of facing:
    • New Vestroia: King Zenoheld is the ruthless leader of an alien race known as the Vestals, who enslaved the Bakugan to use them as entertainment against their will, passing them off as inanimate playthings. After they were freed and revealed as sapient beings, something which horrified most of his followers, Zenoheld designed the Bakugan Extermination System to commit genocide against them. His own son, Prince Hydron, fares no better as Zenoheld treats him as a disposable pawn, abusing and torturing him to take out his frustrations at losing. After his genocide attempt is foiled, Zenoheld loses it and decides to wipe out all life in the universe, including his home world of Vestal, out of petty spite for being defied.
    • Gundalian Invaders & Mechtanium Surge part 1: Emperor Barodius is the sadistic leader of an alien race known as the Gundalians and hero Dan Kuso's Arch-Enemy. Barodius invaded and planned to eventually destroy the peaceful world of Neathia in order to capture a powerful artifact known as the Sacred Orb, which would allow him to control all Bakugan and conquer all of reality. Barodius cares nothing for his men, and treats them as expendable pawns to use and abuse, having them tortured for failing him or having them killed in order to gain an advantage. Eventually defeated by the heroes and imprisoned in an alternate universe for eternity by Code Eve for his attempted genocide, he was mutated there into Mag Mel. As Mag Mel, he formed a psychic link with Dan Kuso and Drago, which he used to torment Dan with terrible visions of the destruction he intends to cause on Earth. Barodius, now as Mag Mel, declares war on his homeworld of Gundalia, intending to wipe it and his people off the map before being stopped. His newly created Co-Dragons Mistress Sellon and Anubius are expendable as well, Mag Mel killing the former despite her begging him to stop and the latter for living out his use. Mag Mel, after being fully revived, has all humans transferred to the dark dimension where he plans on torturing them. At full power, he sends monsters to the five biggest cities on Earth in order to drill to the Earth's core and blow it up, releasing a large amount of energy which he will use to wipe out the entire universe.
  • Banana Fish anime:
    • Abraham Dawson is the scientist who, prior to the main story, found a dangerous drug-like substance known as Banana Fish along with his brother Alexis. After this, Abraham then experimented on his friend by using Banana Fish on him, resulting in the friend's death. Bullied by other soldiers when he went to The Vietnam War-—Iraq War in the anime-—he then uses Banana Fish against other soldiers, including Ash Lynx's half-brother, Griffin Callenreese, in order to pit them against each other. Returning from the war, he then tries to improve Banana Fish and sells them to the Corsican Mafia, led by Dino Golzine for more profit. After finding out that Griffin is still alive, Abraham shoots him in a fit of paranoia. His worst act is when he experiments on one of Ash's friends, Shorter Wong, by brainwashing him with the Banana Fish in order to kill Ash's Morality Pet, Eiji Okumura, while taking a personal delight from all of this.
    • Eduardo L. Fox, aka Edward Foxx, is a ruthless mercenary who faked his own death to escape prosecution for war crimes. Returning under the employ of Dino Golzine, Foxx begins killing at will, wiping out the allies of Ash, taking Ash hostage and raping him to place him under Foxx's control. When Ash escapes, Foxx is only too happy to torture his friends to find out where he is before pursuing Ash to the Foundation. Intending on seizing control and keeping Ash as a broken figurehead slave, Foxx betrays and guns down Golzine while trying to kill all of Ash's allies, intending on ruling over the Foundation with no regard to the misery he spreads.
  • Basilisk:
    • Original manga: Tenzen Yakushiji, the Number Two of the Iga Clan and the true Big Bad, absolutely leaps heads and shoulders over any of his fellow ninja for sadism, cruelty, greed and monstrosity. Secretly a centuries old former Koga himself, Tenzen has nothing but loathing for the Koga and little use for his own Clan. When Princess Oboro seals away her mystic eyes, Tenzen attempts to rape her before being stopped by a Koga attack. Engaging the Koga ninja, Gyobu Kasumi, Tenzen hears how Gyobu's father was murdered by Iga and in their duel, tricks Gyobu into striking at a child, forcing the boy's father to take a fatal blow, solely so the child's pain rattles Gyobu enough for Tenzen to win. Tenzen sadistically toys with other ninja and abandons his loyal student Koshiro because Koshiro had objected to his actions with Oboro. When Tenzen captures the beautiful Koga shinobi, Kagero, because her powers make raping her impossible, he brutally tortures her by impaling her with needles, before attempting to rape Oboro with intent of forcing her to dispel Kagero's powers to force himself on her as well. When he faces off with the young Koga leader Gennosuke, Tenzen reveals his intent to destroy all in his path, end the war victoriously and force Oboro to be his bride while he rules Japan from the shadows through the young shogun.
    • The Ouka Ninja Scrolls: Joujin has the Treasures of Koga and the Flowers of Iga massacred to show off the abilities of his team, the Joujinshu. Seeking to turn the world into a living hell to satisfy his desires, Joujin attempts to implant the soul of Oda Nobunaga in the bodies of others, a process which kills them, and seeks to use Tadanaga Tokugawa as a host, later having him eliminated when he proves troublesome. He then attempts to force Hibiki Iga and her twin brother Hachiro Koga into incest for his plot, trying to kill them when they refuse and having their friends killed. In a different timeline, Joujin happily has Edo turned into an inferno, before trying to kill Hachiro and Hibiki again, before trying to rape Hibiki to create a new bloodline with which to send the world to hell.
  • Battle Angel Alita:
    • Manga: The Super Nova incarnation of Desty Nova, in his introduction, betrayed the main characters and the other two clones of himself to Aga Mbadi. He then proceeds to gleefully tell Alita how LADDER is going to send down an army after the Z.O.T.T. to wipe out The Scrapyard and capture all people on Tiphares for their brains, just before destroying Alita physically and mentally by telling her her brain was replaced with a chip and deconstructing her body, causing her remains to fall down a shaft all while maniacally laughing about it and celebrating over her despair and sadness, disturbing even his other clones. When he asks if the clones would like to work together with him and they politely decline, stating that their methods have grown too different, he uses his power to kill NovaPod and would have killed Nova X if he didn't unplug communication.
    • Battle Angel OVA: Stripped of all his redeeming qualities from of the manga, Vector is a cruel crime lord who reigns over Iron City. Stringing along young Yugo with promises to send him to Zalem, Vector has Yugo and others illegally remove the spines of cyborgs in a black market trade to enrich himself, while also funding highly illegal operations. Vector even executes a victim himself to prove a point to Yugo about witnesses. When Yugo is caught, Vector calmly sells him out to be killed. Not content with this, Vector also keeps the scientist Chiren under his thumb with promises to return her to Zalem, extorting sex from her in the process. Vector later reveals what going to Zalem truly means: murdering people and harvesting them for their organs, which he does on a monthly basis, uncaring why so long as he profits.
  • Battle Royale (manga): Yonemi Kamon is the administrator of the Battle Royale Program, where high school students are forced to kill one another. His hobbies are watching students kill each other, killing students and joking about said students' deaths. After taking a school bus full of students including Shuuya and Yoshio to be transported into the Program, he later mentions that he also went and raped an orphanage director Shuuya and Yoshio had grown close to. Unlike the movie portrayal of the Director, Yonemi doesn't even pretend to buy into the crap about maintaining order or protecting the honor of the Empire. He enjoys raping and killing, and is a huge fan of the Program because he gets to see teenagers deal with gut-wrenching emotions before dying horribly. Even soldiers are visibly nervous around him.
  • Belladonna of Sadness: The nameless baron represents the worst excesses and cruelties of the nobility. When Jeanne cannot pay the exorbitant fee for a wedding, the baron rapes her and allows his courtiers to rape her as well. Taxing the people into starvation, the baron tortures his tax collectors for not taking in enough, including Jeanne's husband Jean, whose hand he removes. When he finds his wife sleeping with a Page, he kills them both, while also growing jealous of Jeanne's growing power and influence as a witch in curing The Black Death. When Jeanne refuses his overtures, he angrily orders her burned at the stake.
  • Berserk: Even in this Crapsack World, a few characters stand out.
    • Griffith/Femto is the Fifth Member of the Godhand. When he was still human, he was a cold-blooded narcissist who dreamed of ruling his own kingdom no matter what it took, was willing to use his friends to commit political assassinations for him, and displayed intensely jealous behavior towards Casca and Guts. Realizing his followers are able to lead their lives without him, Griffith, in his rage at them daring to care for people besides himself, summons the Godhand, damning their souls in return for becoming the godlike Femto. With his newfound power, Griffith, as Femto rapes Casca while forcing Guts to watch, her Brand of Sacrifice causing her so much pain from his action that she is driven into a comatose state. This act also corrupts her child, turning it into a warped Fetus Terrible, which Femto eventually bodyjacks so that he might be reincarnated into the world, setting himself up as a Dark Messiah. Femto later fuses the mundane world and the supernatural worlds together. Defined by his selfishness, and positive that Despotism Justifies the Means, he is a figure of utter hatred to those who know his true nature.
    • Wyald is one of the first Apostles encountered and one of the nastiest pieces of work that Guts and company meet before the Eclipse goes down. A depraved hedonist, he works for the King of Midland and leads a band of mercenaries made up of the worst murderers, rapists and all around scum that Midland has to offer—and even they are terrified of him. His motto is "Excitement and Enjoyment", which translates to raping and murdering dozens, including children. He demonstrates an utter disregard for his men's lives, frequently triggering traps and getting them killed, solely so that he can laugh at their deaths. Taking his true, massive, monstrous form, Wyald states his abhorrent intent to brutally rape Casca to death.
    • Ganishka, the Emperor of Kushan, became insanely paranoid when his mother tried to poison him for his younger brother to become the heir, only for the brother not to survive. His paranoia got to the point where his own son tried to kill him out of fear he would see his son as a threat. After accepting the Godhand's offer he has become a near-perfect example of The Caligula, which shows in mass executions, ethnic cleansing, using conquered populations as human shields or cannon fodder for his armies, attempting to rape the captive princess Charlotte and suspending women over a pool filled with hungry crocodiles, and dropping thousands of pregnant women into cauldrons with stitched-together Apostles to turn the unborn babies into half-human demons that rip apart their mothers upon birth.
    • The Prototype: Vlad Tepes, the Big Bad, is a monstrous tyrant who, during a war with a neighboring country, was ruthless enough to capture and impale five hundred prisoners on stakes and leave their corpses to rot on the borders as a warning. After the war, Vlad decided to satiate his bloodlust on his own people by taking young girls as maidservants, only to slaughter them mercilessly. When Guts infiltrates Vlad's castle in order to rescue Fricka, Vlad is revealed to be a grotesque, gluttonous Apostle who offered his humanity in exchange for inhuman powers, and then attempts to kill both Guts and Fricka, bragging about how a "mere human" is no match for him.
  • Beautiful Bones: Sakurako's Investigation anime: The mysterious painter Hanabusa, known as "The Sphenoider", is the shadowy mastermind behind many of the cases. Obsessed with the sphenoid bone, Hanabusa's modus operandi is to get close to potential accomplices and corrupt them. Once he gains their full trust as some type of angel, he abuses them for pleasure, such as giving them a scar shape like a butterfly, before convincing them to commit heinous crimes for him such as murder or suicide, claiming this will give the victims butterfly wings to be "free". Once the crime is done, Hanabusa takes the sphenoid bone from the corpses and adds it to his collection. By the time of the story, he's responsible for countless cold cases which he orchestrated and sets his eyes on Sakurako and Shoutaro after they foiled a number of his plans. A twisted man, Hanabusa is a criminal genius who will stop at nothing to fulfill his dark obsession.
  • The Big O:
    • Alan Gabriel is a terrorist, Serial Killer, thrill-seeking psychopath and traitorous agent of the group the Union. Carrying out the assassination missions of Alex Rosewater, Alan delights in hurting others and particularly enjoys targeting cyborgs. Regularly organizing destructive terrorist attacks on Paradigm City, Alan frequently casually adjusts his allegiance between the Union and Rosewater, basing it on whichever side is currently partaking in attempted devastation. Ultimately choosing to serve under Rosewater when he offers Alan a giant robot "Megadeus", Alan breaks a death row inmate out of prison and oversees an attack on hero Roger Smith's manor, capturing the android Dorothy Wainwright for Rosewater while enjoying the destruction his robots bring upon the city. Piloting his Megadeus to combat Roger, Alan goes on a rampage, intending on slaughtering and massacring everyone he can.
    • "Missing Cat": Eugene Grant is a truly despicable Mad Scientist convinced that he is a god due to his recent discoveries in transmutation. To constantly improve his alchemic transmutations, Eugene kidnaps innocents by the dozens and transforms them into pain-stricken abominations that he keeps alive and on display for no particular reason. When many of his old partners abandon him because of his depravity, Eugene has one mauled by one of his monsters, and kidnaps two of his former compatriots' son Roy before turning the boy into a cat, following this up by murdering said couple in front of their son. Eugene proceeds to transform Roy into a monstrous chimera, then sics it on Roger Smith while he holds Smith's partner Dorothy at gunpoint, ordering Roy to destroy first Smith, then all else in his path. Despite being a Villain of the Week, Eugene Grant handily stood out as the most wicked and irredeemable monster in the series alongside Alan Gabriel.
  • Big Order: Hanzo Hattori, a seemingly-polite member of the U.N. Providential Government Security Council, is revealed to be a willing accomplice of Gennai Hoshimiya's plan to cause the Second Great Destruction. Hattori kidnaps Sena Hoshimiya for their plans, with their failure causes entire cities to be obliterated. After Gennai dies and Sena lies about her intention of causing a new Great Destruction out of sadist misanthropy, Hanzo admires her apparent sadism and becomes her right-hand man. He helps her to overthrow the government and tries to prevent the protagonists from stopping God from swallowing the world, all of which is motivated because the idea of causing pain at a massive scale amuses him.
  • Bio-Meat: Nectar: Jean Cloche is a silly-seeming but sinister man who manipulates a violent general to ensure he gets control over production of the world's food source in a time of mass starvation. When the titular monsters threaten the only Japanese island not overrun by them, Cloche engineers their invasion and flees. Responsible for the prior outbreak of the bio-meat creatures in Japan and the deaths of 100 million innocent civilians, when called out for his actions, Cloche shows nothing but smug indifference to his crimes.
  • Biomega: Niardi, also known as Nyaldee, is the Overlord of the DRF, and is responsible for all of their crimes throughout the manga. Developing a god complex due to her tremendous "empathy" powers, Niardi spread a virus across the Earth that turned all it infected into ravenous zombies. After decimating much of humanity with this virus, Niardi created her own world, which she named The Recreator, and populated it with numerous bio-androids, all with human-like emotions. Centuries later, Niardi first razes an entire village of innocent bio-androids to the ground, then rips out the lone survivor's womb in order to use it to perpetrate the birth of Niardi's daughter. Niardi then tries to murder and absorb the powers of her own daughter in order to wipe out the remains of humanity, along with the bio-androids, then start over and create another world which she will reign over as sovereign. Convinced of her own superiority above all else, Niardi is a genocidal psychopath who saw all other living things as insects to be crushed under her boot.
  • Birdy the Mighty anime's first season: Satyajit Shyamalan is a Corrupt Corporate Executive with an insane Social Darwinist philosophy of only the "Chosen" deserving life. Locating an alien weapon called the Ryunka, Shyamalan seeks to use it to "cleanse" the world. Murdering those in his way, Shyamalan later strangles the host of the Ryunka's grandfather to death and hooks the Ryunka up to a device of his own making to amplify its powers, killing many, many people with the intention of completely annihilating humanity save those he deems worthy of life.
  • Black Bird: Kuzunoha Shuhei stands out as the most vicious, misogynist bastard around. The leader of the Kitsune Demon Clan who sets his sights on the magical heroine Misao Harada, Shuhei attempts to rape her after disguising himself as her love interest and the leader of the Tengu Clan. After being foiled by Kyo and the rest of the Tengu clan, Shuhei manipulates a member of the snake demon clan into having Kyo poisoned before invading the Tengu territory, before attempting to injure Misao badly to abduct her. Shuhei gleefully states he doesn't care how badly he hurts her as long as he can force her to bear his heir.
  • Black Butler: Dark and twisted as the world Ciel Phantomhive and Sebastian Michaelis inhabit may be, some inhabitants can manage to disgust even a demon:
    • Manga:
      • Baron Kelvin, once a kindly philanthropist, became obsessed with young Ciel Phantomhive and steadily went deeper into darkness. Founding his own circus known as the Noah's Ark, Kelvin would recruit children from orphanages to serve as performers, with many killed performing dangerous stunts, to Kelvin's amusement. Those injured or killed were sacrificed for the experiments of "The Doctor," Kelvin's right-hand man. Worse still, Kelvin used the performers of the Noah's Ark Circus as his personal army and kidnappers by threatening the safety of the children from the work houses they came from. After meeting Ciel, Kelvin revealed he had constructed a replica of the day Ciel was sacrificed, with multiple children tortured into empty shells of their former selves. It was soon revealed that Kelvin had long since broken his word to his subordinates: the work house they came from was long since burnt and abandoned, with the children having been dead for years.
      • The Doctor, Kelvin's number two, is a man who only cares for his experiments in prosthetic limbs. Fashioning new limbs from the bones of children, the Doctor takes those who are injured or killed by the circus and harvests them for "spare parts," with Ciel surmising that he had long ago killed the work house children. After Ciel kills Kelvin, the Doctor seems entirely unconcerned with anything but continuing his work and attempts to sacrifice a child on the makeshift altar to prove to Ciel why Ciel should hire him.
    • Anime:
      • Angela Blanc/Ash Landers are a dual-gendered, shapeshifting Fallen Angel who are disgusted with what they see as mankind's "uncleanliness". Ostensibly loyal to the Queen of England, the angel killed Ciel's parents are part of their plan to "purify" the world and regain favor in God's eyes. The angel horrifically turns multiple girls into dolls, using their bodies as an army of puppets. During a curry contest, the angel gives a spice to a contestant which causes those who eat it to go into a berserk rage. When Ciel goes to investigate their cult, the angel fuses the bodies of both of his parents together to torment him. When the Queen fails to live up to the angel's standard of "purity" by refusing to lose a part of her late husband which had been implanted into her, the angel leaves her to die before using a demon dog it had corrupted to burn London as part of its insane mission. Not even holding itself to the demands it puts on humans, the angel's devotion to purity is a hypocritical one, as the female personality, Angela, is a sadist who shows arousal when torturing Sebastian.
      • Lord Trancy, the former head of House Trancy, has a creepy taste for little boys. He refers to his boys as "dolls" and subjects them to beatings and abuse while holding them as sex slaves for his pleasure. We see Lord Trancy have multiple boys brought to him at one point, his intention to pick the "best" out so he can sexually abuse them. In the first episode of Season 2, we see Alois Trancy, his adopted son, naked near Lord Trancy sleeping in bed, with a cold, vacant look in his eyes.
  • Black Cat: Doctor Kosuke Kanzaki sadistically conducts a number of awful experiments over the course of the series, including transforming a man into a werewolf; brainwashing captured bounty hunters into fighting their friends; and trapping Train in a illusory world where the very people he cares about most are trying to kill him. Fascinated by ten-year old Eve's power to shapeshift, the Doctor kidnaps her towards the end of the series, planning to vivisect her in order to discover how her abilities work. Loyal only to himself and driven by his need to know, the Doctor outshines even Creed Diskenth when it comes to villainy.
  • Black Clover:
    • The Kotodama Devil (Word Devil), real name Zagred, is revealed as the true Big Bad behind most ills in the manga to date. Long ago, this demon swayed the humans of the Clover Kingdom into attacking the elves, exterminating the entire race, before possessing their leader Licht to destroy the human world. Defeated, Zagred reincarnated the elves with a dark spell, letting one elf named Patry lead the terrorist Eye of the Midnight Sun to do as much damage as possible and revive the others to destroy humanity. Revealing himself, Zagred gloats about all he has done to the world before trying to manifest fully, then tortures Patry, breaking him spiritually to transform him into a mindless dark elf and gleefully has him attempt to wipe out the heroes. After stealing Patry's Four-Leaf Clover Grimoire and transforming it into a Five-Leaf Clover Grimoire to obtain more power, Zagred proceeds to open a doorway to pure darkness, seeking to consume the human and elven races alike.
    • Rades Spirito is a vicious, vengeful Evil Sorcerer who decides to attack the Kingdom of Clover. Using his curse which enslaves the dead to him, Rades bombards the city with magic blasts, and unleashes his zombies to devour everything and everyone they find. Rades then takes time to mock and terrorize a little girl before trying to kill her as well, only being stopped by Asta's intervention. When Rades reveals his unbelievably petty motivation (he was kicked out of the Magic Knights for using dangerous magic) for wanting Clover destroyed, he proceeds to sneer that "reasons are best when they're simple" and declares his belief that as one with powerful Mana, he is free to do whatever he wants to those weaker than him, even if he is destroying a country and killing everyone inside.
  • Black Lagoon: In this Crapsack World, filled with terrible people, none manage to be quite as hateful—or fundamentally petty—as Chaka from the "Fujiyama Gangster Paradise" arc. A Yakuza lieutenant with a penchant for Domestic Abuse, Chaka makes his entrance beating up Rock in an effort to impress Revy. When the battle between the Yakuza and the Russian mob goes badly for the Yakuza, Chaka kidnaps and brutalizes Yukio, his boss's teenage daughter, beating her bloody, and plans to sell her to a sexual sadist as part of his plan to take control of the remnants of the Yakuza. When Revy and Ginji arrive to bail her out, Chaka shoots through his own men to try and get at them, kills another man for daring to try and run away, then runs away himself, leaving his men to be massacred. Childish, stupid, and completely out of his depth, Chaka manages to make an impression only through his complete lack of conscience, loyalty, or human decency.
  • The Black Museum: The Ghost and the Lady: Sir John Hall is a revolting old man who manages Scutari Army Field Hospital during The Crimean War. Intentionally mismanaging his hospital due to his extreme hatred towards the soldiers, who he views as nothing but fodders for war, his negligence resulted in the wounded soldiers dying a slow, painful death, with the mortality rate reaching 52%. He also mistreated the patients during his tenure as the hospital director during the Battle of Waterloo. Haunted by Le Chevailer D'Eon's ghost since he was a child, he conspires with D'Eon to eliminate his own enemies. When Florence Nightingale attempts to improve the conditions in Scutari Army Field Hospital, Hall attempts to get rid of her by any means necessary, such as ordering D'Eon to murder her or sending slanderous reports towards the England government regarding Florence's management at Scutari Hospital. During Florence's tenure at Balaklava Hospital, Hall tricks her by inviting her to become a nurse of Transport Corp so that he could murder her, and when Florence's supernatural guardian got critically wounded by D'Eon, Hall mocked Florence.
  • Black★Rock Shooter: The Game: In the manga adaptation by TNSK, White★Rock Shooter is the catalyst of mankind's extinction. Posing as an alien idol singer, W★RS has herself cloned by a scientist named Gibson while her forces attack the Earth. Gibson makes a failed attempt to kill W★RS after finding out about her appetite for her progeny, prompting W★RS to call for the destruction of the human race. She proceeds to kill all but two of the clones and beat one of the surviving clones, Nana, before falsely telling her that Gibson never loved any of them. Sensing that the remaining humans have found the final clone, Stella, W★RS orders her enforcers to kill them. She soon kills two defectors, along with their new human allies, and plots the destruction of the Earth just to spite a third defector. Afterwards, she forces another enforcer to kill Stella and Nana, promising her death should she fail or succeed. Confronted by the two surviving clones, W★RS strips Nana, fakes her death, beats Stella to near-death, mutilates her arm, and taunts her by spitting out the apparent remains of Nana. As their fight nears its end, W★RS asks Stella to help her conquer another planet and crush its people's wishes so she can rule over them for the rest of time. Cruel and self-centered, White★Rock Shooter would without hesitation or remorse kill anyone who she felt wronged her.
  • Black Tiger, by Osamu Akimoto: "The Boss" and Black Jaguar are Human Traffickers. With the prohibition of slavery, the Boss turns to Natives to profit, killing through their villages and taking the women and young girls to sell as sex slaves. Black Jaguar eagerly assists in this endeavor, killing a multitude of innocent US Marshals, while being a client of the girls himself. After he betrays and guns down heroine Black Tiger, Black Jaguar is interrupted attempting to rape a slave, when Black Tiger comes to save the slaves, prompting the duo to decide to burn a native village to the ground in retribution. Even when caught, Black Jaguar betrays and murders the Boss to pass himself off as having infiltrated the Boss's operation—an excuse that fools Black Tiger for not even a second.
  • Blade of the Immortal: Shira is a sadistic, misogynistic Serial Killer and the most depraved member of the Mugai-Ryu. When hunting the Itto-Ryu, Shira rapes, tortures and mutilates a kind prostitute named O-Ren, leaving her to die after he's done. When he initially teams up with Manji and Rin, Shira puts on a facade of acting like a human being, only to torture and attempt to rape another prostitute serving a decoy for the Itto-Ryu leader, trying to murder Rin when she attempts to stop him. Losing a hand to Manji as a result, Shira grows more and more unhinged with dreams of vengeance to the point he willingly submits to twisted immortality experiments to combat Manji. Raping a woman to death and keeping a boy with a grudge against Manji named Renzo as a helper and Sex Slave who he violently abuses on a regular basis, Shira proceeds to massacre the Shogunate's forces sent after him and kidnaps Rin. Tying her to a dock, half submerged with a boulder tied to her feet in the dead of winter, Shira attempts to force Manji to choose to drown saving her or leave her to die to face Shira himself. Shira proceeds to attempt to murder his other nemesis, O-Ren's beloved Magatsu, while trying to cripple and rape a Shogunate kunoichi assisting him. When finally defeated, Shira uses his last words to implore Renzo to abandon his revenge, only to crush his spirit even further by spitefully telling him to never listen to men like him.
  • Blaster Knuckle: While all the beasts that our protagonist—the African-American Victor Freeman—hunt and eat humans, this duo stands out as notoriously cruel.
    • "Coffin for the Weak" arc: The Major is a beast disguised as the Major of a racist rural town. Having eaten humans from all races, the Major decided to focus on African descendants due to considering them easy prey. Taking advantage of the racism of his time, the Major allies with The Klan and other racists to execute all whites sympathetic to the black population, and is then free to abuse them, with him personally eating the corpses of victims of lynchings. Capturing a unlucky black girl with the help of racists, the Major proudly confesses having eaten her sister befor locking her in a room filled with the bones of his victims, with the intention of enjoying her fear before eating her as he already has done with other victims.
    • The Unnamed Beast from the town of White Rock Valley is beast with the power of taking over the control of his descendants. Using said power, the beast annihilates a entire town of African-Americans and takes control of their bodies, with the intention of forcing Victor to kill black children. Sending his descendants to attack both Victor and the cops hunting him, the Beast later receives the former in his human disguise, setting a trap in the town—whose original inhabitants were slaughtered—to let his descendants kill and torture them, with Alex MacGregor as the Sole Survivor due to his extreme skill. Realizing that both Alex and Victor were members of a beast slaying organization, the Beast sends all his descendants to attack them while taking control of the body of a Alex's friend to guilt trip him.
  • BlazBlue: Alter Memory: Hazama/Yūki Terumi continues to be a monstrous sadist. He burned down the church taking care of the young Ragna, Jin, and Saya and dismembered Ragna by possessing his younger brother. Using his high position in the NOL, he orders Tsubaki to assassinate her best friend Noel. Maniuplating Tsubaki's jealousy, he goads her in the fight proper despite the Izayoi's hurtful side-effects. After having an entire military branch killed to supply life-force energy to the Monolith, Hazama/Terumi encounters Noel and Makoto and severely tortures the latter in order to top off a Mind Rape of the former. Having threatened the world through his own failed experiment, the Black Beast, and planning to do it again for his selfish designs with the Kusanagi, Hazama/Terumi still proves to be an irredeemable monster despite the Compressed Adaptation.
  • Bleach:
    • Shrieker was a sadistic Serial Killer in life who died shortly after murdering a woman named Shibata when, while he was walking to land the final stab, her infant son Youichi grabbed his shoelaces, causing him to fall out of a window. Stealing Youichi's soul and putting it inside of a parakeet, the Hollowfied Shrieker promises that if Youichi can escape him for three months at a time, he'll bring the child's mother back to life (something he can't do). Able to track Youichi's soul, Shrieker kills and devours anybody who tries to help Youichi, feeding off the psychological torment it causes, as much as the actual souls.
    • Szayelaporro Granz is the Eighth Espada. When he was human, Granz was an unhinged alchemist who performed torturous experiments on prisoners captured by his brother. A sadistic player of games, Granz creates voodoo dolls out of his victims, and then proceeds to torture them to death, rupturing one organ at a time, as he cheerfully does to Renji Abarai and Uryu Ishida. He's also the worst boss of any of the Espada, modifying the bodies of his subordinates so that in a pinch he can convert them to raw energy and devour them with ease, using their lives to fuel his own. A sickening scientist, who regards himself as the ultimate life form, Granz takes pride in his unique brand of depravity, and regards everyone, including his late brother Ylfordt Granz, as beneath him, and, ultimately, disposable.
    • Sosuke Aizen is a sociopathic Übermensch with a desire for godhood who considers himself above the notions of morality and decency adopted by "lesser beings." Uncaring for anyone but himself, Aizen has a habit of using and betraying anyone close to him. Examples of this include testing out an experiment by turning his former captain, Shinji Hirako, into a monstrous abomination along with seven other Shinigami officers, trying to kill his subordinate Harribel once she had outlived her usefulness, and impaling his devoutly loyal lieutenant, Momo Hinamori, while hugging her, leaving her traumatized for months. Later, Aizen would outdo himself by creating illusions that tricked Momo's best friend, Hitsugaya, into nearly killing her. Aizen also used Wonderweiss Margera as a tool, erasing all of his intelligence, speech, memory, reasoning and emotions just to turn him into a Power Nullifier against one man's weapon. Once Wonderweiss had successfully absorbed the flames of this person's weapon, Aizen had arranged it so that Wonderweiss self-destructed, nearly taking out a city with him in the process. Finally, when Aizen had achieved Physical Godhood, he tested out his abilities by calmly walking through a human city, knowing that his powers caused anyone who came into close proximity with him to blow up. In the end Aizen ended up killing over a dozen civilians, and planned on doing the same to Ichigo Kurosaki's human friends just so he could mock Ichigo by hanging up their corpses on display.
    • Yhwach is The Emperor of the Vandenreich, the King of all Quincies, and the final Big Bad. Yhwach attacks the Soul Society, killing numerous Soul Reapers, while personally slaying the Gotei 13's commander Yamamoto Genryusai. It is then revealed Yhwach was responsible for the Auswahlen nine years prior—stealing the power from Quincies he deemed "impure"—for all intents and purposes killing them—to restore his own power, which led to the deaths of Ichigo and Uryu Ishida's mothers. Furthermore, Yhwach maintains his power and life by harvesting the souls of those slain in the war, on both sides. On his second invasion, Yhwach callously uses the Auswahlen on his elite Stern Ritter forces, save his own personal guard, when he deems them useless to the coming battle. Finding the Soul King, Yhwach destroys him, nearly sundering the separate worlds, while not caring about the innocents or even his own soldiers caught up in the destruction. Said soldiers offer their aid to the Shinigami once they understand the extent of Yhwach's threat to existence; this Enemy Mine also includes various other factions, demonstrating how dangerous Yhwach is. Absorbing the Soul King's power, Yhwach later uses Auswahlen a third time on his Royal Guard, including his trusted second-in-command Haschwalth, before defeating Ichigo himself, stealing his powers and declaring his intent to bring ruin to Soul Society and the human world, while threatening to kill Ichigo's friends in their happiest moments should they interfere, all to create a world where he won't have to die. Brutal, callous and unrelenting in his selfish belief that everything exists to benefit and empower him, Yhwach stands as Bleach's cruelest and most dangerous villain.
  • Blood Blockade Battlefront: Blank, The King of Despair, the Arc Villain of the anime's first season, is an otherworldly entity that has caused countless tragedies for thousands of years. Possessing the body of a teenage boy, Blank manipulates the boy's sister into bringing him the hero, Leonardo "Leo" Watch, so his can use Leo's magical eyes for his master plan, promising to leave her brother's body if she does so. As soon as she does, Blank goes back on his promise, fatally shooting her and revealing that he intends to use Leo's eyes to destroy the barrier around the city of Hellsalem's Lot that keeps Earth from being torn apart by an alternate dimension. When his ally accuses Blank's apocalypse of being too dull, Blank responds by telepathically throwing around buildings and summoning a horde of zombies, looking on with delight as the terrified citizens are slaughtered.
  • Blood+: Amshel Goldsmith is a researcher obsessed with Chiropterans, The Man in Front of the Man to Diva, and responsible for all the chaos in the setting. Since her birth, Amshel twisted Diva to become a Psychopathic Womanchild easy for him to control, while he used her resulting appetite for death and destruction to profit and increase his own power at the expense of her victims. Living for hundreds of years, Amshel now has the public persona of the CEO of pharmaceutical company Cinque Flèches, and uses his wealth to create a group of artificial Chiropterans known as The Schiff, raising them as Child Soldiers and treating them like equipment, as shown by his indifference to their deaths when they escape his clutches and their shortened lifespans begin to expire. A man with loyalty to none, Amshel even kills his own brother, Solomon, for falling in love with Saya. His false loyalty to Diva is an obvious ruse which even she can see through but chooses to go along with out of loneliness, and when she's killed, Amshel reacts with only irritation and demands to be given her children so he can continue his insane experiments.
  • Blue Comet SPT Layzner: The monstrous Gosterro is a sadistic, brutal Gradosian officer whose only joy is in murder. Gleefully leading his forces in the Gradosian invasion of Earth, murdering soldier and civilian alike, Gosterro cheerfully catches his own men in his attacks, enjoying the deaths of his own soldiers while referring to those he hunts down as "prey" or "meat". Utterly without honor, Gosterro sets up a duel, only to use hidden snipers on his enemies so he can have the joy of murdering them after. With a body count of innocent and soldier alike that eclipses many Gradosians, Gosterro is later made into a cyborg and escapes after committing several more murders, intending on returning to kill all in his path just to satisfy his thirst for blood.
  • Blue Exorcist
    • Ernst Frederik Egin, exclusive to the anime, is a member of the True Cross Order who, despite his claims, is entirely motivated by his racism against demons. Ernst would send men to kill demons and those associated with them, regardless of innocence. When he learns that his daughter Yuri is pregnant with Satan's children, he has her put on the stake to be burned to death, something he had done to many other women before. He even has people watch, but when Satan comes to rescue her, he abandons them all while he escapes. Many years later, Ernst finds one of Yuri's children, Yukio, whom he persuades to his side. He then murders The Order's leadership, becoming its new leader, with his first command issuing all True Cross Academy students weapons forcing them to fight demons, despite many being inexperienced. He also tasks Yukio to bring him his brother Rin Okumura saying he will spare Rin, only to admit he lied once Yukio does this. Ernst proceeds to torture Rin, knowing it would open the Gate to Gehanna where he will drop his nuclear bomb, The Messiah, onto the world, destroying it and eradicating every last demon there. When Yukio offers to take Rin's place, Ernst allows it, but tries to kill Rin anyway. When Satan finally appears and foils Ernst's plans by revealing to Yukio what Ernst did to Yuri, he responds that Yuri was not his daughter for loving a demon and her children are just disgraces to him. Sacrificing all those he see, family members included, Ernst proves that humans can become more evil than demons.
    • Dr. Michael (Mihaeru) Gedouin, the resident Mad Scientist of the Illuminati, spends the entirety of the Izumo Rescue Arc proving himself to be the most selfish and utterly depraved villain in that story arc. In flashbacks, he and his team abduct Izumo, her sister Tsukumo, and her mother to use as subjects in his research on the elixir of immortality. He subjects their mother to horrific experiments that reduced her to a broken, bloody shell of a person, while threatening to use Tsukumo (who was two years old at the time) next if Izumo did not follow his demands. When the heroes storm his laboratory, they discover that he has been brainwashing people who visit the town near the lab and using them as disposable fodder for his experiments, turning them into shambling, semi-conscious zombies. When called out on his atrocities, he actually employs a Humans Are the Real Monsters argument to defend himself, considering himself to be above the people he uses as guinea pigs. Further, it is repeatedly show that his only motivation for his evil is to earn approval from Lucifer. An immature, self-centered bastard who relishes the suffering of others, Gedouin stands head and shoulders above most previous villains in terms of monstrosity, with his actions even disgusting Lucifer.
  • Blue Heaven, by Tsutomu Takahashi: "Papa" Jyunou is a pharmaceutical company owner who knowingly let thousands die from faulty medicine until a vengeful group burned and crippled him. Raising his son, Galph, into a Serial Killer, Jyunou boards the Blue Heaven with him and, learning of an Asian assassin onboard, has Galph round up all the Asians on the ship, killing first the men, then women and children as well. Setting explosives throughout the ship, Jyunou intends to flee with Galph while the rest of the passengers are killed. Using a machine gun to kill any passengers attempting to escape on lifeboats, while proclaiming his supremacy over the "Asian filth", Jyunou even attempts to abandon Galph to "adopt" the assassin, intending to extend his killing spree indefinitely.
  • Blue Seed: Murakumo Yagami in the anime is a ruthless member of the Aragami monsters who seeks power at any cost. Introduced killing any stray Aragami to "purify the herd", Murakumo leads a number of attacks to kill humans and awaken the Aragami ruler Susano-oh. Draining the life energy from an entire town for Susano-oh, Murakumo, later flying into a rage when he learns Susano-oh wishes to turn the earth into a garden paradise, betrays Susano-oh and threatens to kill the heroine Momiji Fujimiya in front of his former partner and Susano-oh's closest subordinate, Momiji's twin sister Kaede. When this fails, Murakumo later returns to drain Susano-oh's power, assuming his true form as the Yamata no Orochi to kill every human in the city and exterminate the entire human race save for a few he will rule over, with only the Aragami he deems strong enough serving him.
  • BNA: Brand New Animal: Alan Sylvasta is a pure-blood beastman seeking to eliminate all of the half-blood beastmen within Anima City. Posing as a benevolent human supporter of beastmen, Alan convinced Nazuna Hiwatashi, a human teenager who recently turned into a beastman, to become the leader of the Silver Wolf Order in order to pacify the beastmen in Anima City. To test the effects of the Nyrvasil Syndrome, he had one of his lackeys subjected to the illness, causing him to destroy a police station with rage and subsequently wound or kill various prisoners and police officers. Alan later tries to convince Nazuna to tell her followers during a concert that she's really human so thousands would unknowingly give in to the Nyrvasil Syndrome. When she backs out of the plan, Alan reveals the information himself, resulting in hundreds of beastmen succumbing to the illness and rioting in the streets. While claiming he wants to save the beastmen, Alan intended on using anti-beastmen robots to turn them all into humans he would rule over, not caring if thousands were killed in the riots and Anima City was destroyed in the process.
  • Bomberman franchise:
    • Bomberman B-Daman Bakugaiden: From Series IV, Dark Koutei, in the form of a giant eye, is the main, and worst, villain of the entire series. One thousand years ago, he and his army attempted to take over a solar system before being locked away by the Big Good; another thousand years later he reemerges. He is a truly Bad Boss: instead of just berating or even firing his minions, he locks them up in strange, inescapable domes, doomed to float around in space for all eternity. There's also the matter of how he procured his son: by kidnapping a child and corrupting him. Koutei manages to be the most despicable villain in Bakugaiden without really trying.
    • Bomberman Jetters:
      • Dr. Mechadoc (renamed Dr. Mechard), while initially appearing to be working under Bagura, is actually far more sinister. Bitter at Bagura for stealing his work, even when Bagura told him it didn't work, he had been plotting behind the scenes to overthrow him, and ultimately, he planned to use his work to cause two planets to collide, which would kill an unimaginable amount of people. Despite seemingly being The Dragon, he usurps the role from Bagura of Big Bad and is the only character in Jetters with no redeeming qualities to speak of.
      • MAX, Mechard's final creation and also known as MA-10, manages to be nearly as bad as his creator. Willingly going along with his plan of colliding two planets, killing millions of people, he develops a strong hatred and rivalry to one of Mechard's old prototypes, MA-0. This comes to a head at the end of the series, where he abandons his creator to kill Zero. At the end of this fight, MAX performs his worst deed of his own accord: once he and Zero are dying, he writes his own data into Zero so he can hijack Zero's body, forcing Shirobon to kill Zero, one of his friends, to permanently eliminate MAX. Despite not coming close to Mechard in his resources, he makes a name for himself in the series and manages to be nearly as vile.
  • Boogiepop Series: Makiko Kisugi, the Fear Ghoul, is a psychiatrist and Serial Killer who terrorized the city five years before the pillar of light was created. Finding the evolution drug inside Nagi's room at the hospital, Kisugi tested it on rats and herself, gaining the ability to sense the fear in others. Discovering that she liked the taste of fear, Kisugi began scaring her patients in the worst conditions, and murdered five young, strong-willed girls by removing their brains while they were still alive, and stalked a sixth would-be victim, because "their souls taste better". Having manipulated Pigeon, Kisugi broke Mo Murder's spine and threw him off the hospital balcony, killing him. The anime explores even more of her crimes, as she had injected her patients, and her own pregnant friend with the drug, just to see what would happen.
  • Brave Series:
    • Brave Exkaiser: Dino Geist is the universe's most infamous Space Pirate, having ravaged and plundered planets across the universe with his crew, the Geisters. Dino Geist would endanger countless human lives to either gain as much treasure as he can, or simply to spite the Kaisers, to the point of attempting to detonate Mt. Fuji and put the 8 million people in the surrounding area in danger, purely to harm the humans the Kaisers cared so much about. On several occasions, Dino Geist takes hostages, both human or Kaiser, to gain an advantage, then tries to kill them without a second thought once he got his way, in some cases even indulging in torture while waiting. Even his own allies aren't safe from his ruthlessness, as both Trader and his own crew are ultimately abandoned to the Kaisers without a second thought when it suits the pirate's goals. Near the end, Dino Geist attempts to kidnap Kouta and take him off world as a trophy solely to spite Exkaiser for getting in his ways, and when that fails, threatens his life get an advantage over his archenemy. Dino Geist eventually casts himself into the sun, taking his own life to insult Exkaiser's belief that all life is a treasure rather than allowing the Kaiser to arrest him.
    • The Brave Fighter of Sun Fighbird: Dr. Jango is a rival to Professor Hiroshi Amano and has an unhealthy obsession towards evil and the ambition to rule over other humans and make them suffer to prove his superiority. Not content with just stealing Amano's works, modifying them for evil purposes, and using them for destructive pettiness, he willingly partnered with Draias and enabled all of Draias's evil acts with glee, having Draias enable his evil acts, trampling fellow humans, and delighting in their suffering; he would even try to usurp Draias if the opportunity presented itself. Absolutely shameless and lacking excuses about his atrocities against his own kind and only selfishly concerned of having him stand on the top of everyone else, Dr. Jango is a prime example of a thoroughly despicable human being in the entire franchise.
    • Brave Command Dagwon:
      • Ark/Arc(h) Seijin is the most vicious of the escaped Sargasso prisoners. The self-proclaimed Emperor of Space, Ark Seijin once wiped out the Kein Seijin, leaving only a single survivor in the warrior Lian. Arriving on Earth, Ark Seijin initiates a series of brutal attacks that leave multiple civilians dead while taking a special interest in torturing Lian. After he decides Earth has resisted him too much, Ark Seijin uses his technology to freeze the entire Earth, which will kill every living thing on the planet, on nothing more than a spiteful whim.
      • Super Lifeform Genocide, the self-proclaimed ultimate perfection in the universe, is the ultimate Big Bad of the entire series, having been revealed to be behind the Sargasso Space Prison takeover from the beginning of the series. Throughout the series, Genocide regularly released deadly prisoners from Sargasso and subtly pushed them to attack Earth, where they carried out various plans that involved the mass slaughter of humans across the planet. Once arriving near the Earth's orbit, Genocide controls the Dagwon group to fight each other to the death for his own amusement, and then attempts to merge with the entire Earth, turning each and every living thing on the planet into a copy of himself and having them butcher any humans who manage to escape his merging wave.
  • Brynhildr in the Darkness: Loki is a member from an ancient and extinct alien race that created humans as food—and is strongly implied to have caused the extinction of said race. Faking unconsciousness for thousands of years, Loki waits until he is "awakened" to fulfill the plans of Takachiho, leader of Vingulf, before starting a massacre, devouring every human in his way and taking a human form, enjoying the horror that he induces in his victims. After fulfilling his goal of eating a Valkyria class Magician to recover his complete form, his first action is swallowing an entire city with the intention of doing the same to the entire human race.
  • Bubblegum Crisis: Brian J. Mason, the Big Bad of the first part of the series, kidnaps a Boomer child so he can gain access to technology that allows him to pinpoint a Kill Sat in space. Mason then has one of his own Boomers go berserk as an excuse to unleash the satellite's laser in a boomer populated area. When he's first shown on screen in episode 3, he heartlessly evicts the tenants of a poor neighborhood and has his demolition crew continue their job even though a woman is still trapped inside the building, only stopping after she is dead to rub it in Priss's face. After his supposed death, he reappears as a Boomer named Largo who manipulates a group of Sexaroids, leading to most of their deaths, and tricks the final Sexaroid Anri into believing Priss had murdered her best friend Sylvie to make Anri stab Priss. Largo then uses his satellite on multiple occupied cities to destroy the bases of his former masters, without caring that the blasts consume city blocks. For all his rhetoric on "equality", he sneers that Sylvie was "just a sexaroid" before killing Anri in front of Priss and declaring his intent to become a god and tries to kill the heroes alongside himself with his satellite out of spite when his plans fail.
  • Buddy Complex: Evgeni Gedar is a 90-something year-old Bizon Gerafil, a Zogilian pilot sent to the past, revealed in the final three episodes of the show to have become the new leader of the Zogilian Empire under a new name. Even back under his old name, he already had an obsession with his childhood friend, Hina Ryazan, and tried to seek vengeance against his personal enemy, Watase Aoba, because he saw Aoba interacting with Hina. At one point, he then forces Hina to do Coupling, causing Hina physical pain. After his time-traveling experience, it was revealed that he was the pilot who tries to kill Aoba during the first episode, and is planning to seek revenge against Aoba after more than seventy years. To this end, Evgeni then overtakes the Zogilian Empire through a Military Coup and orders his soldiers to build a large cannon in space. After Aoba and his companions tries to stop his plans, Evgeni then sacrifices his own men so that he could use the cannon as a test drive, and also to lure in the Alliance members. After one of his subordinates is disgusted by his actions and tries to arrest him, Evgeni then spitefully tries to obliterate the Earth using his cannon in his last moments. Whatever redeeming qualities Bizon might've originally had are obliterated by Evgeni, who ultimately was a spiteful, cruel and petty individual that tries to satiate his vengeance for his wounded ego and pride.
  • Burn Up!: Samuel McCoy is an avaricious nightclub owner who seeks to expand his riches by trafficking innocent girls to wealthy clients. When the police free a girl he was attempting to enslave, McCoy orders more be taken in to replace her and has one of his incarcerated men killed to prevent him giving information to the police. Having captured undercover officer Yuka, McCoy has her tortured and later orders his men to fire upon the force sent to arrest him.
  • Cage of Eden: Takashi Nishikori crash-landed on an island along with hundreds of other passengers and established his power over them by blackmailing them into serving them, only offering them an antidote to a lethal plague with which they had all been infected if they do so. Killing anyone who threatens his power, Nishikori responds to a confrontation with Akira Sengoku's group by torturing them before sending them on a Suicide Mission. Capturing all the female members of Akira's group, Nishikori forces the males to try to rescue them, while intending to execute one girl for each failed attempt. Trying to force the girls to sentence one of their own to death, Nishikori promises his men they can gang-rape the survivors.
  • Case Closed:
    • "With a Bang" case note : The unnamed bomber is the Big Bad of this story. Seven years ago, he and an accomplice used bomb threats in two apartment buildings to extort money from the police. Despite initially planning to not kill anyone, when his accomplice died from an accident caused by police miscommunication, the bomber, swearing vengeance against the police for their "dirty tricks", reactivated an undisarmed bomb, killing the bomb technicians beside it. Four years later, he planted two sets of bombs, one at a Ferris wheel and another at an unknown hospital, using a tricky dilemma to force detective Jinpei Matsuda into sacrificing himself at the Ferris wheel to find the location of the second set. In the present, he critically injured Inspector Shiratori by bombing his car, before sending another bomb threat about two new sets of bombs, one at the Tokyo Tower and another at an unknown high school, once again aiming to to humiliate the police with the same dilemma. Willing to detonate bombs despite being aware of children's presence, the bomber shows nothing but amusement from the police's troubles. When finally cornered, the bomber breaks down and reveals his true colors, a pathetic criminal looking to cause violence and see the police ruined, his original thoughts of vengeance long gone.
    • The Time-Bombed Skyscraper film: Teiji Moriya is an architect with a violent obsession with symmetry. Unsatisfied with his past asymmetrical works, he plans to destroy them in disproportionately violent ways while taking revenge on Shinichi Kudo, who had unintentionally wronged him in the past. Starting by burning down four of his past works, he stole bomb-making materials and created plastic explosives to play a game of cat-and-mouse with Shinichi and the Tokyo police, bombing a park with children in it, a public square, and the Tokyo railway, causing further chaos by designing the bombs so that they explode if the trains slow down, forcing them to speed up. When finally revealed, he attempts to blow up his own house and take the detectives with him. After being arrested, he reveals his greatest plan, destroying his "ultimate disgrace", a skyscraper and a major city center, starting by bombing the exits so that more people will die, all the while taunting Kogoro and Shinichi about Ran being trapped underneath the rubble, with the largest bomb, about to die.
  • Castle in the Sky: Romuska Palo Ul/Ur Laputa, known as Colonel Muska, is a ruthless government secret agent who tried to take the flying city of Laputa by force, being actually a descendant of the Laputean monarchy just like Sheeta. Along the way, he commits many heinous crimes such as kidnapping Sheeta and Pazu, threatening to kill Pazu if Sheeta didn't give him the amulet that held the power to control Laputa. When he finally conquers Laputa, however, he becomes mad with power and proceeds to toss his own henchmen from the floating city, all while laughing about it, and intends to use the flying castle's power to wipe out everything in his way so that he can become ruler of the world. He also threatens to shoot Sheeta's ears off after she tried to convince him that the people left Laputa because it was uninhabitable, and when Pazu arrived on the scene, Muska threatens the lives of both children unless they surrendered the crystal back to him. Throughout the film, Muska showed manipulative and emotionally abusive tendencies, a sense of entitlement, greed, hunger for power, revulsion of "disgusting" natural wildlife that he wanted to have burned down, and a willingness to hurt or even kill children if it got him closer to what he wanted.
  • The Celestial Zone: Moon Monarch is the Overarching Villain responsible for the events of the first series. Murdering her master, the Great Evil, Moon Monarch went on to kill the rest of the Celestial Guardians. Manipulating their disciples into becoming her servants, Moon Monarch forced one to drink human blood to maintain control over her powers. When Lady Herbs refused to aid her, Moon Monarch kidnapped her twin daughters from her village, cruelly blinding both out of spite. To expand her own empire, Moon Monarch butchered and enslaved countless people in her conquest. Confronted by the heroes, Moon Monarch tries to kill one of her own servants for betraying her out of disgust with Moon Monarch's vile ways and tricks Blazing Sun into letting his guard down in combat, killing him and mocking his corpse for his naive trust. Killing her own minions just to test out her new powers, Moon Monarch flies into a rage when she realizes she has been outsmarted and tries to murder both friend and foe to hide her humiliation.
  • Cerberus: Nanbuko in the anime is an Arms Dealer who helps to keep things worse for the countries by both starting and supplying the wars with his weapons. Obsessed with the dragon Dagan Zod, Nanbuko sabotaged an attempt to defeat the dragon for good years ago, killing all of his comrades there, intending on allowing Dagan Zod to kill countless people to create enough chaos for him to profit off of. Nanbuko then attempts to kill all his followers by reducing them to raw magic, betraying even his loyal right-hand woman before gleefully trying to take Dagan Zod's power for himself to spread the "beauty of destruction" personally.
  • A Certain... (Toaru) franchise:
    • A Certain Magical Index: Terra of the Left is the most violent, self-righteous member of God's Right Seat. Using an ancient magical artifact to manipulate the people of a French town, Terra sends them after Touma Kamijou and cares nothing when the riot causes the brainwashed citizens to be attacked by an Academy City attack force. Revealing his intent to launch a full-scale attack on Japan, Terra shows disdain for all non-Catholic lives and shamelessly admits to murdering "heathen" men, women and children to perfect his magic.
    • A Certain Scientific Railgun:
      • Kihara Gensei, the patriarch of the Kihara family, is responsible for nasty experiments on children, which resulted in many of them suffering permanent trauma, all so that he could create a powerful Level 6 Esper. Gensei has no compunction murdering people in his path. The first "sample" of his experiments was his own granddaughter: Gensei overloaded her mind to collect samples from her, and repeated this process on other children as well. Gensei was fond of manipulating his own family members into becoming his test subjects, even though he knew that a massive surge would possibly destroy all of Academy City.
      • His granddaughter, Therestina Lifeline, is just as cruel and twisted. Wanting to follow Gensei's example, Therestina abducted children and put them in comas so she could harvest the samples from their minds. Gensei manipulated the young heroines into providing cover for her, all the while intending to overload the minds of the children she kept under sedation, fully aware this would destroy all of Academy City and not caring as long as she achieved the "perfection" she hungered for.
  • Chainsaw Man: The Doll Woman, also known as Santa Claus, is an assassin out to seize the powers of the Devils. With her power to turn humans into dolls while erasing their minds and personalities, the Doll Woman converts countless people over the world into her puppets while utilizing an old man to adopt orphans so she can raise one as a perfect puppet and sacrifice the others for a Devil contract. Coming to Japan, she converts many people to dolls to attack hero Denji and gleefully attempts to plunge others into hell for a new Devil contract.
  • Chaos Dragon: Lady Kohkaku, a sadistic general for the Kouran nation, kidnaps male children she finds attractive—possibly raping them—before killing them, absorbing their souls to extend her life. When her forces are attacked by rebels in a village, she has her men shoot through the villagers while fighting. After discovering Ibuki is hiding in the same village, Kohkaku returns to raze the whole place, personally setting fire to an orphanage in the hopes the screams will draw out her foe.
  • Chimamire Sukeban Chainsaw, by Rei Mikamoto:
    • Nero Aoi is a Mad Scientist who serves as the series's Overarching Villain. A previous victim of bullying due to experimenting on animals, Nero decided to take over the world by killing off her classmates and configuring them into an army of remodeled corpses. She creates a serum that causes people to become insane and violent, and keeps her childhood friend Yuto around as a pet to molest and mentally torture. Resurrecting herself, she converts the Volunteer Club into the Guardians, a group of knight templars who kill anyone suspected of sin. Kidnapping Kimberly to lure Geeko and company to her lair, she has them pitted against previously-deceased murderers and forces them to kill a crazed, out of control Kimberly that results in the death of Mizushima. Once again resurrecting herself, she partakes in the Mondokanoke prison where her remodeled corpses are tortured, and later hunts down Geeko and Bakutani once they escape, where she ends up killing Geeko and attempts to resurrect her as her most powerful fighter. Obsessed with fueling her own ego, Nero stood out in this twisted world as a selfish psychopath hated by all.
    • Final four volumes: Mari Fuwa is the warden of Mondokanoke, an all-female prison for remodeled corpses. Believing that she can do whatever she wants as the warden, Fuwa creates a festival where she invites rich clients to watch her prisoners engage in grotesque sexual acts and deadly Gladiator Games for their viewing pleasure. Having Geeko imprisoned in order to compete in her gladiator games, Fuwa at one point as Geeko stripped naked, crucified, left out in the cold rain, and whipped after she kills one of her prized prisoners, doing the same to Bakutani after she refuses to partake in the erotic show. Regarding her prisoners as "fools with no hope of a future", Fuwa has them hunt down Geeko and Bakutani in return for their freedom, allowing some bounty hunters to infect them with a gas that makes them kill-crazy.
    • reflesh: Mirei is the true head of the St. Argento Academy. Posing as the academy's student council president, Mirei lures in young girls and remodeled corpses to the academy, where she has them killed to either bathe in their blood or store it in bottles to drink in order to gain power. After Geeko's arrival inspires many first-year students to escape, Mirei personally executes them, laying their naked corpses out in a pile for everyone to see. Desiring Geeko's blood for herself, Mirei uses her tentacle hair to decapitate one of Geeko's friends, before trying to kill Geeko herself.
  • Choujin Sensen:
    • Hitsugi Morio, one of the Espers, was a blind doctor granted sight by FEE. As a doctor, Morio became obsessed with handsome young boys and butchered one on his operating table. Becoming a depraved Serial Killer, Morio hunted down, abducted and dissected numerous young boys between the ages of 6 and 18, preserving their corpses for his collection with the intention of claiming more once his sight returned. Upon facing the martial arts expert Yue, Morio gleefully intends to kill him and add him to the collection, even murdering an innocent doctor when Yue goes for treatment, showing himself as the worst of FEE's chosen fighters.
    • Isaac, Sir Isaac Newton himself, is a member of the Carbinoids, the team of FEE's rival, MATE. He is the most depraved of his team, announcing himself by causing a disaster in Tokyo that kills countless innocents, including the parents of the Tomobiki Rinji, just so he can issue a challenge. In his fight with Rinji, Isaac shows himself to be a violent sadist, torturing Rinji with his powers and even causes Mt. Fuji to erupt without a care to the devastation it causes. Isaac is also gleefully on board with his leader Leo's scheme to kill 95 percent of humanity, without any of Leo's noble goals, and when defeated, he attempts to drag Rinji into the volcano with him.
  • Chrono Crusade: The anime iteration of Aion is stripped of his original counterpart's redeeming qualities to become a remorseless seeker of ultimate power. Having decapitated the leader of Pandemonium, Aion uses her severed head in his ritual and sparks a war in the demon world that kills countless millions. Tearing off the horns of fellow devil Chrono for showing remorse, Aion bestows them upon the young Joshua Christopher, uncaring that they drive the boy mad and lead him to petrify everyone from his orphanage. Taking advantage of a lonely woman, Aion manipulates her into killing an entire town of people as a sacrifice to him, delighted in the control he holds over others. Conducting his ritual for godhood, Aion nearly destroys San Francisco, and when Joshua's sister, Rosette, seemingly stops him, reveals it was her powers he wanted after all. Brainwashing her into becoming his slave, Aion entrances civilians with her healing powers before declaring himself a prophet who has deemed humanity sinful and demands they kill each other. Despite knowing the cost of his power is the destruction of both Earth and Pandemonium, Aion is utterly apathetic to the deaths of billions.
  • City Hunter:
    • Manga: The BMW Devil, an early Villain of the Week, drives an expensive car to abduct, rape, and then murder young women. This unfortunate fate befalls one woman's sister, prompting her to seek out the City Hunter, Ryo Saeba. Upon learning of Ryo's involvement, the Devil murders his one accomplice before trying to murder Ryo as well. Boasting he plans to double his body count, then double it again and again, the Devil attempts to rape his last victim's sister before Ryo interferes. The Devil furiously attacks them both, furious with them for interfering with his "pleasure".
    • Anime: The unnamed leader of the Black Army is one of the most dangerous villains ever faced by Ryo Saeba. Under his command, the Black Army committed acts of terrorism in several countries, and every time he hypnotized an innocent woman to make her believe she was the leader of the group, using her to do the dirty works in his place. After obtaining a nuke, the leader sends a ransom of one hundred billion yen to the Japanese government, threatening to blow up all of Tokyo if they don't pay within 24 hours. When the young Rumi sees them, the Black Army makes several attempts on her life, but she's saved by Ryo Saeba. The Black Army leader decides to kidnap and hypnotize Ryo's partner Kaori, and uses her to try to kill both Rumi and Ryo, and also to lead his henchmen from a distance. Once the police find the nuke's location, they send cars to evacuate the area and some agents to stop the terrorists, but the Black Army massacres all of them. Later, the leader orders Kaori to shoot Ryo, and when the police find his position and come to arrest him, he asks her to activate the nuke and destroy Tokyo immediately out of spite.
  • Claymore:
    • Rimuto is the head of the Organization and the one responsible for its inhumane activities. Rimuto has orphans taken by the Organization, turning the boys into inhuman monsters, either Yoma or Awakened Beings, while the girls are turned into Claymores. The lifespans of Claymores are typically short, either dying or becoming monsters themselves to perpetuate the cycle, with Rimuto having countless killed to keep their operations going. Utterly unconcerned with his test subjects, Rimuto even states warriors who die quicker are best, and when villages refuse to pay the fees, Yoma are sent to wipe them out completely. Throughout the course of the series, Rimuto keeps his warriors as disposable cannon fodder, conducting awful experiments on innocents while being wholly unconcerned with all who die in the crossfire.
    • Roxanne of Love and Hate, a former "Number One" of the Organization, differs from most other villains in the series by being an outright cruel and violent sadist. Initially a low-ranking warrior, Roxanne rose up the ranks by seducing/befriending and eventually murdering stronger warriors after stealing their techniques. Eventually, she set her sights on the existing Number One Cassandra, but when she saw Cassandra's technique, she decided it was unsightly and gave Cassandra the hated moniker "Dust-Eater." She later set up Cassandra's only friend to die a torturous death at the hands of an Awakened Being and mocked Cassandra by saying that her friend had looked as if she had "enjoyed" being played with by the monster, so interfering wouldn't have been right. Cassandra snapped and attacked her. Roxanne used the other 45 warriors as shields, relishing in their fear of Cassandra and cackling at how hideous Cassandra's abilities were. When Cassandra finally reached Roxanne, Roxanne gleefully impaled her head with the pommel of her sword, a technique stolen from her first victim.
  • Code Geass: The psychotic Luciano Bradley is the most despicable member of the elite Britannian Knights of the Round. Joining the group solely so he can kill combatants and civilians alike, Luciano shows even more depravity towards a captured Kallen Kozuki, implying he plans to rape her before being stopped by fellow Knight of the Round, Gino Weinberg. Participating in an assault on Japan, Luciano delights in the chance to massacre everyone in sight with racist glee. A man with loyalty to none, Luciano also takes any chance he can to murder his own men if they get in his way, gleeful at the chance to take any life.
  • Coppelion: The unnamed Three Profesors are a trio of sadistic mad scientists controlling the Coppelion program. Having forced the Dr. Coppelion into exile, the Profesors uses the infant Coppelions for torturous experiments—including the Ozu Sisters, being the real cause behind their violent behavior—while getting rid of the flawed ones by killing them. Intending to capture the ultimate Coppelion Aoi Fukasaku in order to use her to create more, the Profesors kidnap Shion Ozu to torture her and use her as a hostage alongside the remaining survivors of Tokyo. When Aoi gives herself to save them, the Professors attack and kidnap her while keeping Shion. After they escape from their ship, the Profesors send the Lost Retrieval Unit to capture them without care for the survivors while constantly threatening to kill the Retrival Unit if they dare to rebel. Killed for a freed Retrieval Unit, even Kanon Ozu herself is surprised at realizing that behind their masks, they were just normal old humans.
  • CosPrayers: Princess Takitsu, while initially portraying herself as a benevolent daughter of Goddess Amaterasu, is actually the evil goddess known as "The Woman of the Night" who was sealed away. To get free, she manipulates the heroes to destroy the "Black Towers" that binds her under the pretense that her mother was sealed by the towers. After the towers are destroyed and Takitsu regains her true form, she then attempts to destroy the world.
  • Cowboy Bebop:
    • Vicious is Spike Spiegel's former friend and partner in the Red Dragon Syndicate, whose hatred took over when he discovered Spike and his girlfriend Julia were having an affair and tried to force Julia to either kill Spike or both be killed by Vicious, forcing them to part ways and flee. Raising himself up in the Red Dragon, Vicious would commit espionage for the Syndicate against his military superiors during a war before leaving a man who looked up to him to take the fall. Dissatisfied with the direction in which the Red Dragon was headed, Vicious murdered his own mentor, also bombing the transport ship of a rival clan representative sent for peace talks to prevent an alliance Vicious disapproved of. Taking command of the Red Dragon after outplaying their leaders during what was meant to be his own execution, Vicious leads his men on a bloody battle against the attacking Spike, leading to all of their deaths as he faces down with his rival. Merciless, power-hungry and completely devoid of human compassion, Vicious stands as a dark foil to Spike, made all the more dangerous by his matching skill and guile.
    • "Black Dog Serenade": Udai Taxim is a psychopathic assassin and the Arch-Enemy of Jet Black. Introduced after having slaughtered a group of guards on his prison ship to escape, Udai goes on to kill the pilots of the craft. Engaging the police with his gang when they come to stop him, Udai continues his killing spree, having his men wipe out the cops' attack force. Confronted by Jet, Udai reveals that years ago he conspired with Jet's former cop-partner to kill Jet, which led to Jet losing his arm in a shootout, before Udai attacks and tries to kill him once again.
  • Crocodile Precinct:
    • The unnamed warden of this manga's second arc in the series is a cruel, sadistic woman who appears oddly youthful. Running her prison with an iron fist, it is soon revealed the reason for her youth is that she drinks the blood of beautiful woman whom she tortures to death. When the heroine, police officer Mika Hino, is captured by her after instigating a riot, the warden has her men fire into the crowd, not caring if her own guards are killed, and subjects the surviving women to torture by stripping them nude and forcing them to stand in place through the hot sun or freezing rain until they collapse. Mika herself is taken to the warden's torture chamber and subjected to torture, with the warden throwing vinegar on her wounds to wake her should she pass out. The warden then has her attendant try to rape Mika, who gets the better of him and escapes. Her response is to furiously execute the man and promptly demand the guards recapture Mika. Responsible for turning her prison into a hell on earth, the warden lived for two things alone: to remain beautiful and young, but primarily to cause pain to others.
    • The Savage Chimney Island Arc: The unnamed police officer, known as "The Shadow Man", who rules the titular island, has enslaved the villagers and the island with violence and threats. Seeking to mine gold from below the island, the Shadow Man has men and women kidnapped, abusing them horribly, but allows the men to have "play time" where they can rob and pillage around the island at will. Any who try to escape are murdered, with four victims washing up near the mainland, Mika barely evading sexual assault at the hands of the Shadow Man's men when she arrives on Chimney Island. She soon sees the abused, mistreated slaves, with the Shadow Man indicating he plans to dispose of all of them when they serve their purpose.
  • Cross Ange:
    • Prince Julio Asuka Misurugi, heroine Ange's evil brother, betrays her at a ceremony to expose her as a "Norma"; Normas are humans without magic who are shunned and sent to become glorified Cannon Fodder in a war against interdimensional DRAGONs (alien beings). This results in the death of their mother. Julio has their father arrested and promptly executed to seize the throne himself. He manipulates their crippled sister Sylvia into baiting a trap for the now battle-hardened Ange, so Julio can capture her, torture her and murder her himself. When she escapes, Julio, taking advantage of a proposal from the mysterious Embryo to destroy and recreate of the world, eagerly decides to simply "purify" the Norma, regardless of age, and launches a brutal attack on their home of Arzenal to kill all of them, including Ange.
    • Embryo himself, the "Creator" of the world, was a scientist who grew tired of warfare and kidnapped the mighty DRAGON Aura to power the creation of a new world. Embryo creates a system where those without magic are oppressed and used as Cannonfodder to kill DRAGONs trying to recover Aura, while discarding and recreating humans when they fail to impress him. Embryo seduces many of the pilots to his side, using Salia sexually while lying about how he loves her. When Ange herself refuses his advances, Embryo tortures her by forcing her mind to undergo overwhelming pain and then physical need. When Ange tries to escape, Embryo shows his true colors by taking over the mind of her faithful maid Momoka and even tries to fatally shoot Momoka when she resists. Upon the final battle, Embryo simply decides to obliterate all of humanity again, coldly rebuking one of his subordinates for caring about others, and tries to sacrifice his loyal followers to buy himself time. When he is through trying to seduce Ange, Embryo tries to beat and rape her before trying to kill her for not "accepting his love."
  • Cyber City Oedo 808: Shuzo Saionji is a ruthless corporate mogul obsessed with immortality. To this end, Saionji had countless innocents taken and subjected to horrific genetics experiments in a quest to find the secret to eternal life. Only one woman survived, mutated into a vampire-like being. Seeking to acquire her secrets for himself, Saionji had his collaborators murdered and later uses his new knowledge to turn himself into a young, healthy vampire as well before trying to murder his past victim who has come to revenge by draining her entirely of blood to gain her strength.
  • Cybernetics Guardian: Adler Einstein is an elitist scientist who wants to exterminate his city's slums. When another scientist, Layla, tries to research a peaceful solution to the violence in the slums, Adler tries to have her test subject, John Stalker, killed. Using a mechanical suit to get revenge after John injures him, Adler goes on a rampage, killing two innocent police officers and threatening Layla while trying to murder John.
  • Cyborg 009:
    • Skull (or Skarle, Scar, Scarl, or Sekar) is the leader of the Black Ghost organization. He and his men exploit ongoing wars as way to make money by selling their weapons to both sides. In order to complete Black Ghost's "Cyborg Soldier" program, Skull sends his operatives across the world to kidnap people, taking them away from their families and friends so they can be forcibly experimented on. As a way to show off Cyborg 0013's capabilities, Skull has the cyborg rampage across Tokyo, causing massive damage and endangering the lives of countless people all so he can create a spectacle for his investors. Skull later escalates the Muamban Civil War by dealing weapons to both sides of the strife, planning to expand the conflict into other countries simply so he can sell more weapons. Skull is also a user and abuser of his minions, and he will kill his underlings for reasons ranging from failing him to simply being of no more use to him. His primary goal is to provoke another World War just so he can deal more arms and make more of a profit. Skull is ultimately someone with an utter disregard for human life, only caring about the sales of his weapons.
    • (Claus/Klaus, originally Director) Van Vogt (or Van Bogoot or Ban Bogart/Van Bogart), Skull's second-in-command, is a Black Ghost executive who poses as a businessman to cover his exploits. Van Vogt forcibly converts three of Joe/Cyborg 009's childhood friends into cyborgs and sends them out to murder him. When they can't bring themselves to kill their old friend, Vogt activates the bombs he planted in them to punish them for their failure. He later invades the Yomi Kingdom with an army of robots. While liberating the Pu'Awak people from the oppressive rule of the Zattan, Van Vogt's regime proves to not be much better, as he forces the Pu'Awak to work on Black Ghost's ultimate weapon, the Demon Statue. He mindwipes Helen, one of the five Pu'Awak princesses, so he can use her to infiltrate and destroy the 00 Cyborgs' home. One the mission has been accomplished, Vogt leaves her for dead. When Helen and her sisters get fed up with his rule and help the 00 Cyborgs, Van Vogt mercilessly kills all five of them.
    • Dr. Gaia in the 2001 anime is the top scientist of Black Ghost and the creator of the Mythos Cyborgs. An old colleague of Dr. Gilmore, Gaia and Gilmore disagreed on the concept of human emotions, with Gaia believing them to be a weakness while Gilmore thought they gave people strength. Setting up base on Magma Island, Gaia activates his Mythos Cyborgs and convinces them that they're actual Greek Gods who have returned to punish humanity for their sins and create a better world. Gaia then sends them across the world to cause disasters affecting hundreds of people so he can gather energy for his generator. When Artemis begins to doubt the Greek Gods' mission and leaves, Gaia fatally shoots her to prevent her from possibly interfering with his plans, even though she showed no intention of standing in the Mythos Cyborgs' way. Even as Magma Island collapses as a result of his generator overloading, Dr. Gaia refuses listen to reason, instead declaring that he can use his generator to become a god. In the end, Gaia is shown to not care about anything other than proving that his cyborgs are better than Gilmore's and becoming a god.
    • Call of Justice: Emperor is the mysterious leader of the Blessed. In order to evolve the human race more to his liking, the Emperor resolves to initiate a process that will kill 95% of the human population all so he bring 5% under his control. After his initial plan fails, Emperor decides to combine his remaining powers with 001's psychic powers so he can "reset" humanity and rebuild their society from scratch. When his subordinate, Catalina, betrays him after forming a bond with 009, Emperor punishes her by wiping her entire mind and reducing her down to her base instincts. Emperor then announces his intention to do this to all of humanity so he can reprogram them to worship him as a god. Though at first appearing to be a well-intentioned being, the Emperor's true colors are eventually revealed to be that of a egotistical lunatic, who even admits that he "never really had [a heart] to begin with."

    D - F 
  • The Dagger of Kamui (also known as Revenge of the Ninja Warrior): The villainous Tenkai aims to take over Japan for himself. Having the hero Jiro's adoptive family murdered, Tenkai trains him as a ninja and manipulates Jiro into killing his own biological father, before ordering Jiro's village to be slaughtered to the last man. When Jiro learns of his true mother, Tenkai has her murdered too, attempting to manipulate Jiro into leading him to the lost treasure of Captain Kidd in the West, also using Jiro's brainwashed sister as one of his soldiers. Using a body double, Tenkai attempts to have Jiro and all his friends killed, with the double even trying to rape Jiro's sister as well. Finally, during the downfall of the Shogunate, Tenkai attempts to take advantage of the war to finally seize control of Japan, having allegiance to nothing but his own ambition.
  • Damned, by Masanori Kadowaki & Tetsuya Saruwatari: Todoroki Jin's long-lost friend, Ryoga, turned out to be something far worse. After Jin tries to save the latter from his second execution, the latter responded by stopping Jin's heart. After he willfully sold himself to Tokyo Company and become one of the top employees, Ryoga used the slaves that the Tokyo Company kidnapped for his own twisted immortality experiment by stitching their dead bodies into a huge giant and change their neurons so that they could ended up becoming a killing machine while keeping their consciousness alive. Ryoga then proceeds to cruelly tell Jin that the friendship he formed in the past was fake and Jin was nothing but his spare parts. After Jin spares Ryoga, the latter then taunts Jin that he will continue his experiments. Before the final confrontation, Ryoga threatens the secretary to give him the whereabouts of the CEO and then blows his head off after saying that the CEO has interested in Jin, and kills anyone who tries to stop him from meeting the CEO. Although having numerous redeeming qualities in the past, Ryoga is revealed in the present to have become nothing than a hyper-human sociopath who tries to rule Tokyo as a god.
  • Dance in the Vampire Bund: These are the worst foes that Wilhelmina Vlad "Mina" Tepes, Akira Kaburagi Regendorf, and their allies face in the dark world of the titular Bund:
    • Duke Ivanovic is the most vicious and unhinged of the three Lords. After believing Mina's mother had married a commoner, Ivanovic and the other Lords had her murdered out of spite and jealousy and later committed a worldwide purge off all other vampires to put the world under their control. Ivanovic was once Grigori Rasputin, and drove Russia into chaos and ruin, even later trying to enslave and rape Duchess Anastasia till Mina saved her. In the present, Ivanovic plays a game with the other Lords where they hunt Mina's lover Akira for fun and repeatedly subject Mina to a degrading chastity test. Eventually Ivanovic launches a brutal attack on the Bund to capture Mina for his own pleasure. Once there, he deliberately targets civilians, and has the innocent fangless vampires executed to draw Mina out of hiding intending to eventually wipe them all out. He also uses as shock troops werewolves that he's tortured into feral beasts that have forgotten their own humanity. Ivanovic at points attempts to rape Mina when he can and has a disturbing taste for young girls, not caring that Mina is in her younger body as opposed to her adult form; even declaring he'll only enjoy her adult body after he's had his pleasure of the younger one.
    • Rozenmann, the most elegant, handsome, well-dressed, and polite of the three Lords, is also the most intelligent and manipulative. He tricks Ivanovic into invading the Bund, knowing the death and destruction that will result. Planning for his fellow Lord's death, Rozenmann set up Mina to be kidnapped and replaced by a doppelganger whose terrorist attacks he was secretly financing and patronizing. With Mina in his hands, Rozenmann has Akira (supposedly) killed solely to break Mina further, and injects her with a drug to freeze her in adult form to rape her later. While Ivanovic is a wild, furious warlord, Rozenmann manipulates nearly every bad thing to happen in the series, with nary a care as to the many innocent lives or mental trauma he leaves behind him in his quest of domination.
    • Volume 10: Gabe is a New York vampire crime boss sworn to Rozenmann who makes the most of his limited time. He is a pedophile and maker of child pornography who routinely taunts a stripper about paying a visit to her daughter Susy, who can't be more than six. After he learns the stripper is sheltering the runaway Mina, Gabe violently murders her friend and storms her apartment, immediately noticing how Susy is prettier than he imagined and attempting to seize her before Mina stops him. Gabe uses Susy and her mother as hostages so Mina surrenders under promises they won't be harmed. While Rozenmann's honorable werewolf retainer Gerhard is willing to give the assurance, Gabe makes it clear he has zero intention of not coming back for Susy.
    • Dive in the Vampire Bund Volume 2: Radovan Elichenko in life was a Serbian war criminal who, during the Bosnian wars, led his soldiers into a village while the men were away and slaughtered the elderly and the children. The women suffered worse. Any woman in their teens or over were taken and subjected to endless rapes and tortures. To escape justice, Elichenko became a Cudoviste, or monster in the Slavic tongue—a vampire. He then joined Lord Ivanovic and carried out "purges" of any leftover clans in Ivanovic's territory. After fleeing to the Bund and betraying Ivanovic to gain sanctuary, Elichenko was confronted by the father of one of his victims who had become a vampire to hunt Elichenko down. When presented with a picture of the girl he'd raped and tortured, Elichenko sneered he'd done "thousands of Bosniak sluts" and only remembered them by how they looked "down there" before mocking him about having probably slept with his daughter because "Muslim men love to control their women."
    • Memories of Sledgehammer side story: Friar Bolton, the leader of a secret order of vampire killers once employed by the Vatican, murdered his more reasonable superior to take over the group. When a journalist who knew the truth fled, Bolton had him viciously tortured and nearly murdered Reiko, the man's daughter, to make him talk before Inspector Seiji Hama saved her. When serving as aide to a Colombian politician, Bolton empowered cartels to commit crimes over the country and kidnap his own employer's daughter with no intention of returning her alive. When Seiji saved her as well, Bolton had him captured and tortured by the cartel with his limbs removed, his eye and ears gone and his skin flayed before he was recovered by the vampires and placed in the Artificial Beastman project to heal him. In the present, Bolton engineers a series of terrorist attacks with no regard for collateral damage and violently whips his best agent, his predecessor's daughter Clarissa, with intent to send her on a suicide mission to dispose of her. When he faces Hama, he finally attempts to murder the man himself, along with Reiko when she intervenes. When Clarissa fatally poisons him, Bolton uses the last moments of his life to rant about how only he has the vision to see the extermination of all who stand against his ideals and how her father was too weak to see it.
  • Dancougar: General Gildorome is perhaps the single most depraved character in the series. While Death Gaia and Helmut are insane, their way of thinking is extremely straightforward. Shapiro, however, preferred his knowledge of Earth geography and his battle tactics to take down the Cyber Beast Force. Instead of using conventional methods, Gildorome preferred psychological methods, such as using a Lotus-Eater Machine to hypnotize a whole town to kill them when they can't even fight back. In the end, his method caused the highest number of innocent victims in the most brutal way possible.
  • Danganronpa has, besides Junko Enoshima (who can be found at Other Media), this duo from Killer Killer:
    • Rei Shimizu is a nurse who secretly sacrificed her patients to fulfill her morbid obsession. An addict of parasites, Rei would implant their eggs in victims to breed them in a painful and slow process that lasted for a year, before killing them to extract the parasites. When her latest victim Hana was investigated, Rei played innocent, while secretly trying to kill another patient she has also placed parasite eggs on. When Takumi managed to figure her out and stop her attempted murder, Rei reveals to him her operation, showing her massive collection of parasites she extracted from previous victims before merging with them to try killing Takumi and use his corpse as another parasite nest.
    • Ted Chikatilo, known as the "Million Killer", is a member of Ultimate Despair and an infamous bomber who's one of Future Foundation's most wanted criminals. Owning the title of Ultimate Pyrotechnic, Chikatilo has a fascination with explosions and violence, using the Tragedy to his advantage to turn people into "beautiful fireworks". Responsible for a number of bombings and coming off his latest killing spree where he murdered a platoon of Future Foundation agents, turning one into one of his "art pieces", Chikatilo sets his sight on Killer Killer for bragging rights. Knowing Future Foundation was planning to lure him out, he tried to trick Takumi and Juzo, disguised as him, into fighting each other before coming out and attacking the two. When Takumi managed to thwart his attempt, Chikatilo became more aggressive, killing countless people around him, before trying to blow up Takumi, his partner Misaki and anyone around in a wide range explosion. A narcissist of carnage, Ted Chikatilo is one of the worst criminals in the world of Danganronpa.
  • Darker Than Black:
    • Gaiden OVA: Claude, real name Shichi/Xi-Qi, is the Big Bad who stands out from the normally amoral superpowered Contractors by his outright hatred of normal humans. Claude torments his enemies before killing them by using his powers to masquerade as one of their loved ones and seeks to turn Yin into the Person of Mass Destruction Izanami. Claude is even callous enough to turn her into Izanami when she is in a base of Contractors, knowing that this would mean that her powers would kill everyone on the base, showing he cares nothing for his own kind even while trying to make a world where they rule over regular humans.
    • Flower of Darkness manga, by Tensai Okamura:
      • Harvest serves as an Evil Counterpart to Hei, replacing Hei's respect for humanity with contempt, considering them to be weak and pathetic. Harvest possesses the titular "Flower of Darkness" which can be given to a person to grant them powers, but sadistically forces the recipient to kill their best friend in return for power, also giving the best friend a Flower to entertain himself with the struggle. To prove his superiority to Hei, Harvest distributes Flowers to all of humanity in an effort to prove to himself that there is no such thing as morality, then pettily trying to destroy the whole planet when his plans are foiled.
      • The girls' academy volleyball coach, Daisuke Mioka, is a handsome, charming man who takes advantage of his young students by seducing them and secretly making videos of the sex to sell on the internet. When one student finds out, Daisuke tries to win back her trust by having a group of his friends rape her, before sweeping in to act as the hero who saves her. Daisuke also promises his friends that he will be "a little late" so that they can begin violating her before he arrives.
  • DARLING in the FRANXX: Papa and the Vice Chairman are the face of the VIRM, a vicious alien species that assimilates others and exterminates those which refuse their subjugation. Arriving on Earth, the VIRM exhaust the planet's magma supply, leaving humans as a target for the Klaxosaurs and rule the planet as a cruel regime, with those who defy them having their minds wiped or being left in cryo-storage for their disobedience. After a devastating assault, the VIRM attempt to completely wipe out the Klaxo-Sapiens. When Papa reveals himself as the VIRM, he tries to absorb the souls of all humanity before deciding to simply destroy Earth, tormenting the heroes as they try to stop the alien monsters.
  • Date A Live: Sir Isaac Ray Peram Westcott is the absolutely monstrous Director of Deus.Ex.Machina Industries. A sadomasochistic Mage who discovered his love of pain and despair when his village was slaughtered by humans, Westcott uses "revenge" against humanity as a veil to mask his true motive to simply cause destruction. Torturing and experimenting on hundreds of women and children to turn them into his enslaved "Wizards", Westcott summoned the First Spirit years ago, wiping out 150 million humans in the process, and begins hunting down every Spirit to torture and drive them insane so as to steal their Sephira Crystals. Upon obtaining a Sephira by torturing Nia for five years then forcing all the pain from those years on her at once, Westcott ups his game in slaughtering civilians—including children; sending entire fleets of his own troops on suicide missions in between maiming and killing them on a whim; and dragging entire cities into bloody conflicts. Westcott proudly proclaims every last one of his crimes as being nothing but a hobby to him, and when beaten after first trying to rewrite reality to one where he reigns supreme over a tortured humanity, Westcott tries to drag everyone, his own Dragon included, down to death with him, spending his final moments in glee at his former "friends" mourning his demise.
  • Dawn Tsumetai Te: The seemingly affable, mysterious Doctor is the actual creator of the Nightshift virus. Having created it accidentally, the Doctor tried to sell it for profit, accidentally infecting protagonist Takeshi Nagasawa and liberating the virus. Allowing the virus to spread due to scientific curiosity, the Doctor saves Nagasawa's life in order to blackmail him into helping him to hunt other infectees. After the infectees start to develop conciousness, the Doctor blackmails Akemi, another Nightshift infected, into helping him to capture the rational ones in order to create a drug that destroy their conciousness by promising to save her best friend. When Akemi betrays him, the Doctor reveals that he killed said best friend, asking her if she wants to see her body parts before killing her after she attacks him. Despite his charismatic behavior, the Doctor is a selfish scientist willing to betray everyone in order to benefit himself, with every positive act of him being motivated only for his own interest.
  • Deadman Wonderland is a Hellhole Prison run by the the following duo:
    • Tsunenaga Tamaki, formerly a reclusive and indifferent otaku, becomes a tyrant who cares for absolutely nothing but himself and his games. When the Great Tokyo Earthquake occurs, he leaves his mother to die so he could find a backup generator. He is also responsible for designing the prison and forcing prisoners to participate in Death Games by poisoning them upon arrival and only awarding antidotes to their winners. As a sadist who sees defeating the Wretched Egg as a game, he also creates the Forgeries, prisoners who are turned into artificial Deadmen and brainwashed into obeying Tamaki's orders.
    • Rinichiro Hagire, the prison's real director, is a sadistic, sociopathic Mad Scientist who will do anything for his research. Using Shiro as a guinea pig for research on how to improve a person's immune system, Hagire becomes obsessed over his subject's ability to regenerate. From crucifixion to vivisection, Hagire grows fond of conducting brutal experiments on her and becomes directly responsible for her becoming the Wretched Egg. He also manipulates Chan and En to use their Branch of Sin to invade and override other people's bodies and personalities when he's on the verge of death, and cannibalizes the remains of defeated Deadmen.
  • Death Note: Light Yagami is a brilliant, egotistical student who finds the titular Death Note and soon embarks on a quest to become the God of a "perfect" world he will create. After killing multiple criminals with the Note, Light flies into a rage when a man denounces his public name of "Kira" on TV, gleefully murdering the man on the spot. Once FBI agents investigate, Light tricks one of them into killing the others, revealing himself to one agent to gloat and later forcing the man's fiancée into suicide, cruelly taunting her while doing so. Later, to eliminate his chief pursuer and rival L Lawliet, Light pulls a Memory Gambit where he has the Death Note given to a man he knows will misuse it and pulls off a scheme that kills multiple people, including L. After L's death, Light reduces the global crime rate through sheer volume of murders, with a body count stated to be worse than any genocide. Not even lovers or family members are immune, as Light uses one of his two girlfriends as bait for another rival and forces her to burn herself to death, also eliminating any evidence along with her and contemplates murdering his own sister the moment she becomes a liability. When exposed, Light attempts to justify himself as well-intentioned, but is revealed as "nothing more than a crazy Serial Killer''.
  • Deathtopia, by Yoshinobu Yamada: While Kou Fujimura learned that while all the Cheaters harbor dark thoughts, many of them live normal lives. However, the following trio embraces their dark side:
    • Magata Agito, Kou Fujimura's biological uncle, awakened a combination of genes that turned him into the first Cheater. Arrested for having murdered two women after returning to Japan, he was experimented on by his brother-in-law to understand the nature of his virtual immortality. Saved by his own sister despite him having abandoned her, Agito tries to take her body, accidentally awakening her own powers, damning her to have her body being constantly destroyed and reformed, leading to his brother-in-law becoming the Cheater Ud. Naming himself The Master, he manipulates younger Cheaters to become his followers before sending them to kill Ud and steal the deformed remains of his sister to use them for his plan to launch a coup against the Japanese government alongside the military, intending to kill half of the population of Tokyo. When Kou confronts him, the Master leaves him to die in the fire alongside his girlfriend. A man that enjoys hurting his own family, the Master planned to kill millions to create a twisted utopia where Cheaters are free to hurt and kill as many they want.
    • Karen Kirishima is the first major villain and one of the most sadistic. A beautiful assassin who manipulates men into joining her gang, Karen takes the eyes of her favorite victims to keep them in jars. Intending to take Kou Fujimura's special eyes, Karen sends her gang to hunt him. When a man that loved her has doubts and crashes her gang's car, injuring many of her followers, Karen beats him to death and takes his eyes, convinced that "low-level" men like him should be glad for it. A sadistic killer feared even by other Cheaters and a terrible leader, Karen brutally murders her own gang, leaving their scattered bodies as part of a horrific yet useless trap.
    • Mitsuo Okita, aka Reverse , kills people who appeared in magazines by using his power to emit pheromones that prevent his victim from moving before slowly "reversing" their organs, leaving them to die from blood loss and exposed organs. Aware that his power is useless in combat and at long distances, Reverse waits years between his killing sprees, having killed 28 persons, including the family of Yui Kisaragi, who survived due to not being in the house during Reverse's assault. Returning to his old habits, Reverse kills a couple before being lured into Yui's trap. Managing to use his powers, Reverse paralyzes Yui and tells her the details of her family's death before trying to "reverse" her organs.
  • Defense Devil: Elimona is a manipulative, sociopathic Fallen Angel who believes everything exists for her amusement and pleasure. Stripped of her divine position for manipulating humans into warring against one another, Elimona conspired to gain her powers back by manipulating the good-hearted demon Kucabara into being her errand boy. When she reveals her true plans, Elimona poisons Kucabara's friend Idamaria and steals the latent powers of Lilith from her. She sets up the demon world—where demons aren't actually evil—to be subject to genocide at the hands of the angels, while she regains her powers. When she sees Kucabara's brother, Legato, planning to destroy the demon world before the Angels can arrive, she threatens to enslave their souls and submit them to a world of slavery at her and the other angels' feet. Elimona displays a Lack of Empathy for everyone, even her own angel kin, and when defeated, she opts to drag as many of Kucabara and his friends into the grave with her as she can.
  • Demon City Shinjuku: The evil Revi Rah made a pact with the powers of darkness for power due to envy over his fellow pupil Genichiro being superior to him. Promised power in return for granting the demons dominion over earth, Revi Rah defeats Genichiro but is prevented from summoning the demons further than Shinjuku. Men are killed, women raped and children go missing while Shinjuku becomes a twisted hellhole where demons prowl and Revi Rah himself reigns. When Genichiro's son arrives to stop Revi Rah, the sorcerer tries to have the world's president assassinated and use his daughter as a ritual sacrifice so he can complete his work and give demons dominion over all the world.
  • Demon Lord Dante 2002 anime adaptation:
    • God himself is the Big Bad of the series. An ancient energy being who first arrived at the cities of Sodom and Gomorrah, God committed genocide and torture upon the inhabitants when they refused to worship him, before attempting to torture the survivors for eternity. Upon the demons and devils rebelling against him in present day, God engineers a series of horrible disasters and attacks before draining his energy from all the humans he had created, driving them insane and leading to bloody massacres over all of the world with the knowledge God has done this on many, many worlds before arriving on Earth. Sadistic and egotistical, God believes he deserves worship and will enact nothing short of terrible vengeance for any minor slight.
    • Lamia, one of the treacherous devils known as the Four Devil Kings—and possibly the worst of them—leads her forces to a series of brutal attacks that kill many civilians after she is released by God to stop Dante. Not satisfied with this, Lamia begins abducting young men and women, impregnating the women with her demonic spawn and using the lifeforce of the men to feed her progeny. Lamia's common MO is to have her children eat their way from the "mothers" and use them to overrun entire countries, devouring everyone therein. When the devil Medusa interrupts, Lamia attempts to use her as a host as well before trying to devour Dante himself.
  • Demon Slayer: Kimetsu no Yaiba: Throughout this dark world, the following demonstrate the monstrosity of demonkind:
    • Muzan Kibutsuji was born a sickly child in the Ubuyashiki family, but through a doctor's attempts to cure him incidentally became the first and mightiest demon and grew obsessed with his own perfection. Corrupting others into demons by preying on their weakness at their lowest then infecting them using the special properties of his blood, Muzan develops the system where demons feed on humans en masse for power, leading to countless innocent deaths as he maintains this system for over one thousand years, with his blood poisoning and painfully killing any who so much as utter his name. Muzan is also personally responsible for killing the mother and siblings of the young hero Tanjiro Kamado, as well as the demonic transformation of his younger sister Nezuko. When encountered, Muzan escapes notice by turning an innocent man into a demon and siccing him on his wife before killing several other humans in a fit of pique when they trouble him. Muzan orders countless humans slaughtered, and when his subordinates, the Lower Ranks, disappoint him, Muzan massacres the survivors, deciding they are too weak to survive. Later attempting to massacre all of the Demon Slayers, when Muzan knows death is inevitable he intends to turn Tanjiro into a demon to kill them in his stead. A sadistic, cowardly sociopath predicating a survivalist society of bloodshed to maintain his own safety, Muzan stands responsible for the most death and suffering in the series.
    • Gyokko is Upper Rank 5 and an insane artist who creates new pieces with his victims. Upon being sent to the swordsmith village, Gyokko decides to kill everyone in the village after murdering several smiths and taking others to fuse them into a macabre, living sculpture that he tortures by sticking swords through them, gleefully describing how he plans to replicate it on a grander scale with the village innocents. A complete narcissist, when Gyokko finds a smith more dedicated to his work than in noticing him, Gyokko opts to begin torturing him to try to break his concentration.
    • The twisted Enmu, Lower Rank 1, is the only survivor of Muzan's purge due to impressing Muzan with his love of suffering. Muzan promptly empowers Enmu and sets him after Tanjiro. With power over dreams and sleep, Enmu puts Tanjiro and his friends into pleasant dreams that reflect their hearts' desires, while tricking humans into entering their dreams to destroy their minds. Enmu promises to give train passengers kind dreams, but delights in twisting their dreams into horrific nightmares, and when cornered by Tanjiro opts to fuse with the train itself and try to devour all 200 passengers, gloating how he means to torment his victims before he eats them to strengthen himself even more.
    • Chapter 188 ("Sorrowful Love"): The unnamed snake demon in Obanai Iguro's past was a low-level demon with a hunger for children. Bargaining with Obanai's family, the demon would murder people to allow the all-female bandits to live off the stolen wealth in return for them providing the demon with newborn babies on a steady stream to consume. Upon Obanai's birth, the demon had him raised and prepared as a meal, as he was the only boy and had alluringly unusual eyes. Having Obanai's face mutilated to resemble her more, the demon massacred all but one of Obanai's family upon his escape before closing in on him to eat him as well.
  • The Demonic Beast Front franchise:
    • Majuu Sensen, by Ken Ishikawa: Professor Genzō Kuruma, the father of hero Shin'ichi, is one of the 13 Apostles serving God. He seeks to create a new breed of human/animal hybrids called "New-Men" by morphing people's cells, hoping to accomplish everything before God starts his apocalyptic recreation process. Having experimented on Judas's sons and turning them into dust creatures, he starts the story by massacring everyone in the International Science Institute, before using Shin'ichi as a guinea pig for his painful New-Men experiments. Considering Shin'ichi a failure, he decides to experiment on his wife instead, taunting Shin'ichi about her results. Deciding to cast aside his own humanity, Kuruma has Shin'ichi slowly electrocuted to death, then leaves him and his wife to die in a house fire. Continuing to perform New-Men experiments on random people with his fellow scientists for five years, he tries to kill Shin'ichi after hearing he's still alive, and later orders Professor Shaft to flood the earth in an attempt to recreate Noah's Ark.
    • Beast Fighter: The Apocalypse anime:
      • Having survived God's apocalyptic recreation process, Dr. Genzō Kuruma plans to resurrect God and use him to create a new world with him as its ruler. Continuing to plot the death of Shin'ichi, Kuruma sends New-Men out to take him down, uncaring of the innocent casualties. Creating an army of non-binary clones to populate his new world once he floods it, Kuruma locks one of them, Noah, up for being rebellious, calling them a failed experiment. Murdering Ayaka by draining her of her magical blood, Kuruma summons Mars A and Mars B to try and get them to kickstart another apocalypse so that he'll become the new world's God.
      • Episodes 4-7: Chancellor Semimaru is the leader of a small country hoping to become the new God and obtain his powers. Making Dr. Rockry inject the blood of Shin'ichi into him, Semimaru has him locked up to be used as his pet scientist. Seeking the death of Shin'ichi, Semimaru sends his men out to destroy a train full of people and attack a small village. After failing to kill Shin'ichi in Honekami, he orders the destruction of the entire town for bearing witness to the event, uncaring of the millions of lives lost. Torturing and fatally wounding Rockry for information on Shin'ichi, Semimaru dies proclaiming himself the world's only God.
  • Denpa Teki na Kanojo: Kiyoshi Kakura is a Serial Killer who has brutally beaten at least 13 people to death. Once a normal boy, Kiyoshi one day suddenly snapped and raped his neighbor and sister figure Sakuya, her mind breaking due to the horrible incident. After snapping once again later on and killing an innocent high school girl and bragging about it, he and Sakuya, who became obsessed with these deaths, began their killing spree during rainy nights, including the main character Juu's friend Fujishima. After being lured out by Sakuya through an anonymous text, Juu encounters Kiyoshi after his latest kill, where he claims his victims were all aliens and it's his duty to kill them all as a covert agent. After trying and failing to kill Juu, Kiyoshi was arrested for the killings and then killed himself while in prison.
  • Descendants of Darkness: Dr. Kazutaka Muraki, while handsome and charming, has, as of the start of the series, already spent several years systematically kidnapping, dismembering, and vivisecting small children, raping adolescents and infecting them with slow, agonizing fatal diseases, and seemingly murdering every grown woman he comes across, whether to use them in scientific experiments to attract the attention of the Shinigami or just for fun. Muraki also specialized in Mind Rape, whether it's mentally torturing a girl madly in love with him into developing split personalities, mind-controlling suicidally depressed pop stars into becoming blood-drinking monsters, or stalking and harassing one of the Shinigami with so much misdirected guilt that he finally manages to drive him into a catatonic state, in which state he fully intended to vivisect the guy and use his powers to bring Muraki’s older (half-)brother Saki back to life, just so that he could kill him more slowly and painfully.
  • Detective School Q: Horie Takayuki is the primary murder victim of the Psychic Murder arc, but it is quickly revealed that Horie was more than deserving of the death blow he was dealt. Years ago the abusive chief of staff of the National Talent Development Center who seemingly created the project just to get government money, Horie would take in young children and put them through experiments to test their capacity for psychic abilities, horribly beating them if they fell short of expectations. In truth using the Center just to have children at his disposal for him to molest and act out his depraved urges on, Horie eventually murdered one of the children in his care and killed his partner to keep the death silent. Horie gets away with his crimes for years, hurting countless children and taking smug satisfaction in his acts.
  • Devil Devil, by Yūki Miyoshi: The Shadow of Satan was originally a demon soul without a body surviving inside his brother Satan. Hating the world, when Satan fought against God, the Shadow took the opportunity to corrupt both of them, take control of their bodies and divide the soul of his brother into multiple fragments. After the demon Sword fought some fragments, the Shadow ordered his best friend to kill him and when said friend avoids it, the Shadow tries to kill him too. Sending some demons to find the fragments in the human world, the Shadow convinces one of them to absorb his companions before discovering that he planned to absorb all of them. Willingly butchering Satan's resurrection/empowerment to ensure his death, the Shadow takes control of Heaven as God, creating monstrous angel/demon hybrids, turning Heaven into a horrific dimension, and launching an invasion to Hell with the intention to destroy it alongside the human world and heaven itself.
  • Devil May Cry: The Animated Series:
    • Sid is a cowardly lesser demon who will do anything, including murdering children and fellow demons, to rise in the ranks of Hell. Killing a man, Sid wears his skin to manipulate his friend, Nina Lowell, and later threatens Nina's life to force her daughter, Patty, to activate his ritual to summon the great demon Abigail, to absorb his power. Summoning a demon army to slaughter everyone on Earth, Sid cares nothing for the death and destruction as long as he gets to rule Hell, just to eradicate his own inferiority complex.
    • "Not Love": Mayor Mike Hagel's butler is a seemingly well-mannered servant whose true loyalty lies with the demon Belphegor, wishing to sacrifice the entire human population by condemning them to be Eaten Alive. Working alongside the good-hearted demon Bradley in making the preparations for their master's arrival, the butler stabs the mayor and uses his body in a ritual to summon Belphegor for him to devour the entire city while claiming that they would eventually destroy the human world. A human who stood in contrast to his benevolent and demonic partner-in-crime, almost driving his own race into extinction to satisfy his master, he served as an example of how some humans are even worse than demons.
  • Devils' Line: Kirio Kikuhara, also known as Zero Two, is the commander of the Chosen Civil Community, or CCC, an organization dedicated to the extermination of vampires, also referred to as devils. In the past, Kirio murdered his own mother and psychologically tortured half-devil Yuuki Anzai by making him witness his kind's animalistic nature. In the present he orders Nanako Tenjo to assassinate Anzai, while he has Ren Murakami slash a woman's throat in Ikebukuro on live television, leading to the devils there being overcome by their bloodlust and feed on her; this would expose devils to the public, which led to lynch mobs forming to persecute and murder innocent devils. Kirio would then order Ren to kill Nanako when she failed to kill Anzai, before killing Ren himself once he served his purpose. When Nanako survives and helps Squad F expose Kirio's crimes, Kirio arranges nine people to be killed by devils before turning the blood-crazed devils on Squad F, hoping to use the devils to kill them and frame them should they survive.
  • Diabolo: Nebiros is known as the most cruel and twisted of Diabolo's generals. The leader of the Six Great Spirits of darkness, Nebiros has no compunction sacrificing them to meet his goals. When he manifests on earth, he happily tortures a church full of his own worshipers to death with a Slasher Smile on his face. When his survival while inhabiting the hero Rai is threatened, Nebiros tries to break free and possess Rai's friend Ren, to erase Ren and inhabit his body as a shell.
  • Dogs: Bullets & Carnage: Angelika Einstürzen specialized in human experimentation, starting on her test subjects when they're young children. Chronologically, the first thing we see her do is tell Heine, a member of one test group, that if he took part in an extremely dangerous experiment, he'd save all of his friends from the same fate. Once it was clear that the experiment was a success, she no longer needed the rest of the test group and had them go berserk and murder each other, while she forced Heine to watch. Next, she sends a large number of her old test subjects to invade the Underground City and slaughter as many people as they could before she blew her soldiers up. She didn't even do this because she had something against the people she had killed. She just wanted to get rid of her old, defective test subjects, while also getting the attention of the mayor, who resided on the surface. She figured the easiest way to kill two birds with one stone was to blow her men up and take hundreds, if not thousands of innocent civilians with them. Afterwards, she sends one of her many bodies to one of the districts hit hardest by her attack and tells the people there that their friends and family, who had been kidnapped long ago, were among the attackers that the people had killed, just to see how horrified they would be. She also shocked one of a pair of young twin sisters who understandably didn't want to go back to her for more brainwashing and Mind Rape. She does all all of this either for scientific research or just for fun.
  • Dog Soldier: Owing a great debt to American action films, especially those of The '80s, this manga has some very nasty villains:
    • Zardoz, founder and leader of the New Revolutionary Army, is a vicious terrorist responsible for countless attacks, including one that claimed the lives of the parents of John Kyosuke Hiba. In present, Zardoz's men bomb a jumbo jet that is filled with passengers, planning to use the distraction to kill President Ronald Reagan. When this fails, Zardoz has them hijack another plane to fly it, with all passengers, into Reagan's meeting place. When he learns Reagan is in Tokyo, Zardoz and his forces attack an airbase and slaughter all the soldiers before taking the President hostage, planning on seizing control of a nearby nuclear arsenal with no compunction in burning Tokyo to ash.
    • Muammar Gaddafi himself, the dictator of Libya, is secretly working with Dr. Göppel, a nuclear scientist who wants to get back at the US for cancelling his research on nuclear weapons. When the two cause a plane, which Göppel is on, to make an emergency landing in Libya, Gaddafi takes the crew hostage. When Hiba and his friend Fudo go on a rescue operation, Gaddafi has all three hundred passengers massacred, including a father in front of his young son and tortures Hiba by carving a grid into his back and ripping off chunks of his skin. Having worked with Dr. Göppel to design an ICBM hundreds of times stronger than the nuke, and Göppel having set off the weapon with his dying breath, Gaddafi plans to nuke the entire West. When he and Hiba engage in a duel to the death, Gaddafi boasts of consuming the entire West in nuclear fire, not caring that he'll sentence his own people to death by retaliation in the process, as he can simply hide out from the retaliatory strikes in his nuclear bunker.
  • Dokuhime:
    • Queen Datura Metel Mitragyna is the selfish, hedonistic ruler of Mitragyna. To mock the lowborn king of Glandol, Icarus, at a feast, the Queen poisoned common folk dressed as nobles at his table. Icarus allows the neighboring nations free access to Glandol's vast water supply, on the condition they cease hostile action, including banning Mitragyna from exporting poison, enraging the Queen. Using assassins known as "poison princesses" to create political instability, the Queen tries to have the Glandol king assassinated and when this fails, poisons the water of another country, framing Glandol to start a war.
    • Mandrake raises the poison princesses by having them ingest food and drink laced with poison, even violating them with a poison-coated stick, until all of their bodily fluids will kill any they touch. Using the girls as assassins, Mandrake cares nothing for them and has those who fail their missions or run away hunted down and burned at the stake. When the Queen orders a nation's water supply poisoned, Mandrake has a young poison princess decapitated and her body thrown into the stream to infect it with her blood.
  • Dokuro:
    • Aiichiro Kanehira is the repulsive, greedy founder and leader of the Nirvana Church of Creation, a Corrupt Church which exists solely for his benefit; Kanehira doesn't even believe in the tenants of the Church. His followers go into debt to give money to the Church, some even committing suicide; Kanehira doesn't care. While not killing anybody himself, Kanehira has his Church Police kill at least dozens, possibly hundreds of not more of enemies. He also has an orphanage where children are abused, raped, and generally treated horribly. He also allows, if not orders, horrendous medical experiments, and organ trafficking, including some of the children. Finally, Kanehira takes advantage of his followers; in one instance, he took sexual advantage of the mother of hero Kikuchi Takeo, then just cast her aside like a piece of garbage. This resulted in her killing herself and trying to kill Takeo as well; this in turn motivated Takeo, a former elite member of the security unit, to take down the Church. While Kanehira at various points seems to care about his followers or his daughter, at the end, Kanehira Aiichiro is shown to care about nobody but himself.
    • Kawashima Junta is the chief prison guard of the sanatorium where Takeo is sent after killing a corrupt police officer. Previously, he was in charge of Kanehira's orphanage, where he beat and abused the children, including them making them drink from bowls like dogs. He also raped-—possibly more than once-—Takeo's friend Mudo. In the sanatorium, Kawashima hosts the Rumble Fish, where he would pit prisoners against each other; the fight could only be stopped by Kawashima, who loved seeing them kill each other. When a prisoner calls Kawashima a "maniac", Kawashima responds by shoving a pencil through said prisoner's mouth and nose. Finally, Kawashima took part in the organ trafficking, both at the orphanage and at the sanatorium.
    • Professor Koganei works at the sanatorium, and is responsible for the organ trafficking and medical experiments. He works with medical companies, and uses the prisoners as guinea pigs for testing new drugs. He doesn't even believe in God, but is a member of the Nirvana Church of Creation, as they allow him to conduct any type of experiment, legal or not. He considers taking the prisoners' organs "recycling of trash". He had the sanatorium's actual warden locked up and drugged for a few years. Finally, there are the "zombies", humanoid abominations trapped in an And I Must Scream state.
  • Dolls Fall: Headmistress Chloe Zola-Kanno fell in love with killing the helpless when she witnessed her own orphanage headmistress go mad and kill her friend and began killing orphans with her. Seeking to resurrect an evil witch by torturing and killing virgins, Chloe spends a century bringing girls with special powers to her orphanage by killing their families and bathing in their blood to stay eternally young. Renting the girls to the townsfolk to use for sex rituals, when a pair of reporters upload Chloe's crimes to the internet, she goes ballistic, ordering all the orphans killed, before having her staff commit suicide to appease the witch's bloodlust.
  • Domu: A Child's Dream: Old Cho, real name Chojiro Uchida, is an elderly man with Psychic Powers and the mind of a sadistic child. Routinely driving the residents of his apartment complex to suicide—with over 30 victims in under 3 years—to steal their belongings and keep them in a room, Old Cho reacts to investigators brought in to investigate the mysterious deaths by mentally torturing one of the lead investigators and forcing him to jump to his death. Barely stopped from making a baby crawl off a balcony by young psychic girl Etsuko, Cho retaliates by possessing a man and trying to make him try to stab Etsuko to death and then forcing the man to cut his own throat in front of Etsuko, traumatizing her. Cho later possesses Yoshikawa, another tenant, in another attempt to kill Etsuko, scoring a number of other murders through him—including two of children, the latter of Yoshikawa's own son—and then rigs a series of gas leaks around the complex, causing a series of explosions that cost dozens of lives. Maintaining a childish glee when committing his atrocities while simultaneously demonstrating he knows full well what he's doing is utterly wrong, Cho is petty, selfish, and views people as nothing more than toys for his own amusement.
  • Doubt: Hazama Rei is a petty psychopath who, upon having her talent for hypnosis slandered and her part on a magic TV show criticized, grew to despise all of humanity for "rejecting" her abilities. Thus, using the game "Rabbit Doubt" as a basis, Rei began hypnotizing people into slaughtering others, using her hypnotic abilities to convince her subjects that their own loved ones were coercing them into it. After getting well over a dozen innocents killed this way, Rei pulls the stunt once more, leading to the deaths of several teenagers in particularly gruesome ways, and, even when one survives, Rei uses the memory of her dead parents to trick the survivor into getting himself killed, promising him as he dies that she will continue her crusade against humanity for as long as she lives.
  • Dragon's Dogma's "Gluttony": The Mayor is a gluttonous pig of a man who has a Cyclops eat children under false pretenses that they are ritual sacrifices; he would only spare those who hand over all their food to him, while letting them starve to death. When Ethan and Hannah battles the Cyclops, the Mayor has his men attack the duo, potentially putting them in danger of facing the Cyclops's warpath.
  • Dragon Slayer (1992 OVA): Ackdam, the Demon Lord, is a powerful Evil Sorcerer who invades the kingdom of Faaren, massacring everyone in his path, wiping out the capital city and personally killing the king. Ackdam proceeds to set up a horrific regime where citizens are starved, enslaved and killed at the will of the king and his minions, opposed only by a small rebellion and the renegade prince Sirius. When Sirius rescues a village from Ackdam's minions, Ackdam reacts by sending his chief minion Zagi, in dragon form, to wipe out the village to the last man and attempts to capture Sirius to execute him with his captive mother the Queen, wishing to rule Faaren no matter how many people have to die.
  • Dream Dimension Hunter Fandora: Yog Sothoth/Yogu Sotho Sogos is a dimension-traveling criminal who desires absolute godhood. Once a nice young man living on Deadlander, his life began to change after the destruction of his planet and the death of his girlfriend Fontaine. Consumed by despair and hatred, he later finds the Endora jewel, gaining powers after the jewel absorbed the evil in his heart. Becoming drunk on his new powers, he proceeded to conquer the planet Aura, killing Fandora's royal parents in the process. Taking over the Kingdom of Lam, he slaughters the king and queen, brainwashing their daughter Leimia to serve him. Posing as Pope Gilsburg, he rules the kingdom with an iron fist. Seizing Fandora's Lupia jewel, he forces her to fight over a pit of spikes for his own amusement, killing Leimia after she frees herself from his control. Seemingly defeated, Yog resurrects himself and recreates Deadlander as a planet populated by dimensional criminals. Posing as the God of Blue Light and resurrecting Fontaine as his maiden, he creates a physical manifestation of his remaining conscience named Sotho, ordering him to bring the Lupia jewel in return for Fontaine, planning to combine with both him and the jewel to obtain more power. Once Sotho realizes who Yog is, Yog kills him and Fontaine, destroying Deadlander again. Becoming a starship captain, he sets out to conquer every dimension, having already conquered 1/3 of them. Coming close to achieving ultimate power, he tries to kill Fandora for her Lupia jewel.
  • Dream Eater Merry anime: The seemingly-friendly guidance counselor Ryota Ijima and his Dream Demon "Mystleteinn" Treesea are vicious partners-in-crime who gratify their mutual sadism by implanting Dream Demons in the students Ijima counsels, whereupon Treesea butchers them and leaves the students as hollow, apathetic shells. Treesea previously establishes her nastiness through a vicious massacre, and Ijima glories in breaking the dreams of the students who trust him, even brutally beating one by kicking her head. In their battle, Treesea imprisons Merry in a bud of despair to drown her, mocking the subsequent failed Heroic Sacrifice as "worthless" as Ijima gleefully beats down the heroes himself.
  • Dream Hunter Rem: Professor Shinigami, real name Dr. Shimura, was a sadistic Serial Killer of women in life who kept the bodies of his victims in suspended animation before being supposedly killed. Returning as an entity capable of murdering people through their dreams, Shimura returns to old habits by butchering countless more young women in their sleep and even trying to torture the young daughter of the cop who tried to gun him down to death in revenge. When Rem plunges into his victim's dreams to fight him, Shinigami eagerly attempts to kill her too through a swinging axe to slowly cut her open and bleed her out.
  • Drifters: Aram is a knight of the Orte Empire, in charge of patrolling its lands where he would oppress the elves there, take their women to be made sex slaves, and kill any wandering Drifters. Burning elf villages for not paying their taxes, he personally kills the village elder who tries to stand up to him, before ordering his men to kill off all the elves in the village, children included.
  • Drifting Classroom: In this story taking place After the End, some people are driven to violence out of despair or survival, but two characters proved themselves to be evil for the sake of evil:
    • Kyusaku Sekiya was originally a friendly deliveryman who is revealed to have a penchant for harming children. After he is brought to the future, Sekiya threatens anyone who comes close to the kitchen, even burning alive the teachers who tried to reason with him. After a boy attempts to save a girl who was taken as a hostage, Sekiya fatally stabs him, and after killing the boy, Sekiya travels through several classroom while beating innocent students and stealing their lunches while demanding that they cry, informing them that he is perfectly fine with allowing them to simply starve to death. Seemingly defeated by the hero Sho Takamatsu, Sekiya threatens to stab a three-year-old if the students didn't obey him. Fighting against a giant centipede, Sekiya throws a boy at it and leaves him to be Eaten Alive. Traumatized by the experience which caused him to have a harmless child-like personality, Sekiya comes back to his senses after a boy pushes him down the stairs and forces him to swallow a strange mushroom, which ends up converting him and other children into spider-like mutants. Taking control of the school and turning it into a military-like dictatorship, Sekiya trains the boys to be his own Child Soldiers and sends them to their deaths when the mutants attack the school, while escaping with the food supply.
    • Scar Kid, the Arc Villain for Volume 5, is a budding psychopath and a fearmonger who leads a rebellion against Sho Takamatsu in the midst of a bubonic plague outbreak, igniting a war between the students. Starting his reign of terror by burning patient zero alive and trapping all of those who were close or merely affiliated with Sho inside a building, Scar Kid wants to burn them alive to reduce the school population by half, with his soldiers not above executing their own. Realizing that he himself is infected, Scar Kid touches Sho to spread the plague further, declaring that if he is infected, then everyone should also die a slow and painful death. Even after discovering his infection, Scar Kid still burns the building and orders his boys to throw spears and rocks at the windows to stop the students from escaping alive. Not warning his army about his infection on purpose, they also die from the plague before Scar Kid himself succumbs to The Black Death.
  • Dr. Stone: Minister Ibara is the true ruler of the Petrification Kingdom. Having petrified the true leader with the weapon "Medusa", Ibara tried to kill said leader's baby son to remove any "witnesses". Reigning as a tyrant, Ibara has women abducted for the leader's harem, with the rule he is allowed to "sample" them first, gloating how he loves them to put up a struggle first. When Senku and the heroes of the Kingdom of Science alive, Ibara tries to petrify them forever, even sacrificing one of his followers to that end. A lecherous, fiendish tyrant, Ibara cares only to satisfy his own lusts for women or control.
  • EDENS ZERO:
    • Guilst (aka "Planet Guilst Assault") arc: Illega is a bloated frog alien who pays criminals to kidnap and bring him women, who he turns into stone statues to be used as furniture. Once Rebecca uncovers his room containing hundreds of stone women, Illega arrives holding Copa at gunpoint, promising to release her should Rebecca kneel before him and become his toy forever. When news of the planet destroying Chronophage arrives, Illega plans to start his collection again on another planet.
    • Digitalis (aka "Hermit") arc:
      • Spider goes by the name Jamilov in the digitized world of Digitalis. Cheating to give himself an advantage, Jamilov wanders through the fantasy computer world, slaughtering the living NPCs for fun, while taking a special joy in murdering player characters so he can also kill them in the real world, exterminating entire towns. When he arrives at the town Shiki and Rebecca are at, Jamilov tortures and impales several PCs upon a spike to let them die slow and gleefully brings an army to massacre every living thing there, even trying to murder a child for an advantage. When thwarted, he tries to erase the Eden's Zero and kill everyone aboard the ship for sheer spite.
      • Dr. Müller was initially presented as a kind scientist from Planet Newton who aids an android named Hermit to complete a contraption known as the "Accelerator" under the pretense on saving Hook, a neighboring planet filled with androids. In truth, Müller manipulated Hermit to build a superweapon to obliterate Planet Hook, and after said planet is obliterated, Müller reveals his true colors by saying that humans are superior to machines, before beginning to torture and dismantle Hermit for research and for his own amusement.
    • Sun Jewel arc: Kurenai Kogetsu, aka Madam Kurenai, was a slave freed by the heroine Valkyrie. Rather than return to her lost daughter Homura, Kurenai married the slaver Baron Mordo and murdered him to take over the planet Sun Jewel. Running the world as a horrific tyrant, Kurenai uses an orbital cannon to vaporize anyone who defies her and amuses herself via sadistic games such as burning a model's face off and using him as a broken pet. Upon the rebellion of the mining districts, Kurenai decides to exterminate them all, including her own daughter, simply to show she is not to be defied and to punish them for still honoring Valkyrie's memory.
  • Elfen Lied: The unnamed hitman is a sadistic, pedophilic monster hunter. To find Lucy, the hitman mutilates, then rapes, a silpelit diclonius, leaving her powerless and without her vocal cords to be used as a radar system. Hunting for Lucy, the hitman tries to rape her human friend, the defenseless teenage girl, Mayu, disgusting even his fellow Blood Knight hitman, Bando.
  • The Eminence in Shadow: Crimson is a brutal vampire supremacist who corrupts and forces the kindly Elizabeth, the vampire progenitor, into waging war with humanity, leading to the destruction of several countries and countless dead. With Elizabeth sealed away, Crimson rules Outlaw City as a place of horrid atrocities as he awaits the time to revive her. Crimson sets his minions to kill off the humans of the city while planning to reawaken Elizabeth in order to cull humanity and put them under the foot of vampirekind.
  • ERASED:
    • The Serial Killer, Gaku Yashiro, is the intelligent and gleefully sadistic murderer driving the plot forward with his killings. His cruel tendencies arising as a child who alleviated his boredom by drowning pets and luring young girls to his rapist older brother, the killer eventually murdered said older brother and gained a taste for killing, primarily of young children. As an adult carrying out his long-time fantasies of killing dozens of children and framing innocent people for the crimes, the killer flings his fiancée out of a window when she becomes suspicious of his crimes, and stabs Sachiko Fujinima to death when she realizes his true identity. When Sachiko's time-traveling son Satoru tries to thwart his crimes in the past, the killer tries to drown Satoru before murdering his way into a political position solely to allow himself easier access to potential victims. In his final confrontation with Satoru, the killer tries to drown the man's close friend Kumi while forcing Satoru to watch, before attempting to evade capture for his crimes by burning himself and Satoru alive, bragging even in defeat how he has done nothing morally wrong, merely indulged in a hobby he truly enjoyed.
    • The unnamed, manga-exclusive, and flashback-only older brother of the killer manages to stand out as horrific and monstrous despite only appearing in one chapter. A sociopathic bully, the brother regularly assaulted his own little sibling and other kids at his school. Showing his true monstrosity, the brother formed a partnership with the willing killer where, after the killer lured little girls to him, he would rape them, a process that went on for years and resulted in dozens of rapes. When the brother accidentally strangled one of his victims to death trying to keep her from calling for help, he tried to frame his younger brother for the crime, showing no regret or empathy for his victim. Though only a teenager, the brother made his mark as the most monstrous character in the story along with his brother.
  • Erin: Duke Damiya, in the anime, is the scheming nephew of the High Queen Harimiyah of Shin-Ou, and seeks to take the throne for himself. To this end, Damiya has Harimiyah assassinated, making his niece Seimiya the new queen, and frames her beloved Shunan for the incident, which makes the already tense situation between the nations Shin-Ou and Tai-Kou reach its breaking point as open war begins. Slowly isolating Seimiya from those who could help her, Damiya manipulates her into agreeing to marry him for political power. Blackmailing heroine Erin into helping him weaponize a beast called the Ouju by threatening a school of children, Damiya begins having obstacles assassinated, only to poison his loyal assassin once the task is done. Seimiya reveals that Erin has provided her with proof of Damiya's treachery and orders his arrest, preparing to offer terms of peace with the Taiko's people. Unfortunately, Damiya has already given the order for his private forces to take the Touda and massacre the incoming Tai-ko forces, thus kick-starting a full scale war between the kingdoms, during which he plans to use Erin to train him a massive and ravenous army of Ouju to dominate both kingdoms at their weakest.
  • Eureka Seven: Dewey Novak put his top fighter Anemone and multiple girls like her through torturous experiments to make them Tyke Bomb soldiers. Anemone was the only survivor, but her mind was severely damaged. In order to gain support for his war efforts, Dewey engineers enormous levels of civilian casualties, using the Coralians as a scapegoat to convince humanity they cannot coexist and must wipe out the Coralians. His motivation is that his world domination plans have no place for the Coralians. He is also motivated by a petty grudge with his younger brother Holland, and he even prepared to destroy the universe should he fail.
  • F-Zero: Legend of Falcon: Black Shadow is the ruler of Dark Million, and the always-grinning chessmaster behind every single bad event in the series. Black Shadow, atop facilitating general terrorism and abusing underlings as a course of habit, has gone to every length imaginable to prevent Ryu Suzaku from stopping him. Black Shadow creates the homicidal criminal Zoda and sends him off to homicidal rampages—at one point powering up Zoda to annihilate all of Mute City—and kidnaps Ryu's girlfriend Haruka to brainwash her into his pet assassin, Miss Killer, trying to use her to kill her own boyfriend. Black Shadow carbonizes Miss Killer when she finally breaks free of Black Shadow's spell, and gleefully torments Ryu with her petrified body. Black Shadow, in the finale, reveals his glorious dream that his every waking moment has been dedicated to: Using his Dark Matter Reactor, Black Shadow throws the entire galaxy into death and destruction, to precede him creating a new Big Bang to annihilate the old universe and create a new one of pure evil on top of it.
  • Fairy Tail:
    • Acnologia, the Black Dragon of the Apocalypse, was once a hero who protected humans from dragons. Succumbing to bloodlust and a love of combat and destruction, Acnologia embraced his transformation into a black dragon, massacring the entire dragon race, even his own allies. Becoming a terrifying scourge on the world, Acnologia annihilates innocents for fun, stopped only from conquering the world by his own boredom. Upon his second appearance in the story, Acnologia brutally kills his old enemy, the Fire Dragon King Igneel, in front of the latter's adopted son. When he decides to take center stage in Alvarez's invasion of Fiore, Acnologia targets the other Dragon Slayers to wipe them out and reveals his intention to simply annihilate everything that lives, while keeping the only immortal wizards as playthings to torture forever.
    • "Phantom Lord" arc: Master Jose Porla of Phantom Lord, motivated by ceaseless but unfounded envy towards the Fairy Tail Guild, orders Gajeel to destroy their home base in Magnolia Town and hang up the violently beaten Team Shadow Gear as an example. After incapacitating Makarov, who he holds a special enmity towards for a mere drunken outburst, Porla kidnaps Lucy and holds her for ransom to acquire the entire Heartfilia family fortune. Going to extreme lengths to satisfy his hateful jealousy, Porla orders the activation of "Abyss Break" to annihilate all of Fairy Tail as well as the innocent civilians of Magnolia Town.
    • "Edolas" arc: Faust, the King of Edolas, supposedly desires eternal magic for his kingdom, but in the end only wants it for himself. He conducted a plan called "Anima" to absorb all of Earth Land into Edolas as Lacrima for fuel, but his son Mystogan eliminated most of the portals save for one in Magnolia City. Consumed by greed, he eventually orders the genocide of all Exceeds and uses his army's desperation for Magic to rile them. During "Code ETD", he siphons the Dragon Slayers of their magic to create a chain to throw the giant Lacrima containing Magnolia City residents and facilitate in Extalia's destruction. When Mystogan thwarts it, Faust personally leads a final assault in the Dorm Anima, callously shooting down his son and promising to turn Natsu, Wendy, and Gajeel into living batteries to fund future Anima plan attempts. His burning of Coco's legs and disregard for Pantherlily's life in a crossfire ultimately out Faust as a power-hungry and avaricious king.
    • "Tartaros" arc: The "Etherious" Jackal, member of Tartaros's Nine Demon Gates, is a sadistic psychopath who assassinated the Magic Council. A lover of Sadistic Choices, he forced a former councilman to choose between his life and that of his own granddaughter. Later, he imposes one upon Lucy where he will either detonate an elder councilman or a pregnant woman. Already viewing humans as mere playthings, Jackal later pettily kills one of his own guildmates, showing his monstrous nature extends to even fellow demons.
    • Dragon Cry: Zash Caine was once a wizard of Fiore who fled to Stella after a failed coup. He went into the service of King Animus and then proceeded to kill his own allies to prove himself. In the present day, Zash uses mind control to force the White Tiger squadron to kill each other in order to steal the Dragon Cry. Zash shows no hesitation in trying to kill the Fairy Tail wizards, and is even willing to mind control others to do so. It is revealed that Zash keeps female prisoners to draw blood from to power his own magic, and takes Lucy captive in an attempt to draw blood from her. Towards the end, Zash betrays Animus and takes the Dragon Cry for himself. He proceeds to force Animus to go on a rampage and unseals the Quartum Army to eliminate the Fairy Tail wizards. He then activates the Dragon Cry in an attempt to destroy all of Fiore out of revenge for his exile, only failing when the power proves too much and incinerates him.
  • Fang of the Sun Dougram: Helmut J. Lecoque is a heartless politician from earth who serves as an aid to the hero Crinn's Anti-Villain father Donam Cashim. Continuously pushing Cashim to be more brutal with the Deloyer rebels, when Cashim finally dies, Lecoque assumes command and proceeds to make the war bloodier than ever, committing war crimes and instituting brutal internment camps for prisoners while getting countless innocents and soldiers killed. Merrily intending to escape justice by making the figurehead leader Carmel take the fall for his crimes, Lecoque orders the targeting of civilians to draw out the last of Deloyer's resistance, intent on rising to greater power no matter what he has to destroy.
  • Fantasies, by Gen Osuka: Philippo, leader of the Bloods, is a Fantasy user whose model is "Vampire". Killing his rivals, Philippo uses their organs for the black market trade while also being a vicious Serial Killer on the side who drains women of blood. After killing a rival, Philippo takes the women to drain of blood, and even feasts on a random woman fatally later. Philippo, upon incurring the wrath of the benevolent gang Junk Hole, decides to come and massacre everyone in their territory before taking all the women to feed his depraved thirsts.
  • Fantastic Children: Georca is the brother of the King of Greecia. Desiring to take Greecia for himself, Georca sends his men to bomb the king's quarters, which ended up killing the princess. Overhearing the scientists' conversation regarding the princess being turned into a living weapon, Georca kidnaps one of the scientists and then lures the princess by using her mother as a bait. He then proceeds to mentally torture the princess, resulting in her uncontrollable powers being activated, in turn causing Greecia's destruction. When the Princess calms down after using her power, Georca then proceeds to attack the castle in order to retrieve the princess. It was also revealed that he is the one behind his son's Start of Darkness by beating his mother in front of him.
  • Fatal Fury manga, by Ken Ishikawa:
    • The Martial Emperor, born three millennia ago in China, desired to advance his skills beyond mortal comprehension and threw himself into battle to kill countless people. At one point, he even annihilated an entire nation's army on his own. Making a pact with demons, the Martial Emperor entered a deep sleep with instructions on sacrificing martial artists to him to restore him. Upon his awakening, he begins absorbing the life from fighters all over the world and consumes his own loyal followers before announcing his intentions of ravaging the world and making it into a new hell where countless die so that he can feed his hunger for battle
    • Geese Howard, in stark contrast to his game counterpart, is a cruel demonic overlord who uses his army of demons to conquer villages and enslave their people. Desiring to bring the Martial Emperor back to life in order to rule the world with him, Geese orchestrates a fake fighting tournament where the winner is chosen as a fuel source to increase the Emperor's power. Kidnapping Andy Bogard—whose master Geese killed years prior—Geese hooks him up to a machine and promises him the death of his friends. When he finds Terry and the others getting closer to the Golden Temple, he sends Jirai to stop them, letting him mind control Andy to fight his brother and friends. Once the gang makes it to the Golden Temple, Geese tries to kill them, hoping to stall long enough for the Emperor's incomplete reawakening.
    • Liuo Himmler is the sadistic, cyborg leader of the Devil Street's Fourth Dragon Factory District. Appointed by the Martial Emperor, Liuo has his goons kidnap men and children to be used as slave labor for manufacturing weapons. Executing workers who attempt to escape, he threatens those who try to run away with the promise of killing three returned child slaves. Getting into a fight with Joe and Bear after promising to make them his slaves, Liuo tries to kill the returned children with a spike chandelier.
  • Feng Shen Ji:
    • Bai Lian manages to eclipse many of his fellow Jerkass Gods for evil. One of the Sage Kings of heaven, Bai Lian engages Wu Geng in combat and reminds Wu Geng of when he was enslaved in the mines. It is then revealed Bai Lian has murdered every slave who ever befriended or helped Wu Geng and presents their preserved heads to him. Bai Lian says he had no reason to kill them, he just felt like it. He is also forcing the mines' master, who loved the slaves, to assist him by holding the man's beloved son hostage. When Wu Geng convinces Master Li to help him, Bai Lian orders the child killed without a second thought. He also lures Wu Geng to where Wu Geng's grandfather Fu Yi is held hostage so Wu Geng will be forced to euthanize him. Bai Lian chose that spot solely so he could bask in Wu Geng's despair, knowing what the young hero would be forced to do and how it would affect him.
    • Shen Yen is responsible for the entire plot, spanning 100,000 years. Originally he was Pangu, the leader of ancient gods, an uncaring bigot who believes everything below ancient gods to be beneath him & waged a war with ancient dark ones in order to annihilate them. During the war, he saw the power of Hei Long and then tried to kill him as well as his wife, which backfired on him as Hei Long slaughtered the entire pantheon out of anger. Later he was revived as Shen Yen, who was given authority over punishing any god who breaks the rules (i.e. not considering humans or dark ones as something beneath their boots) and dark ones. He was the one behind the spreading of patrification sickness within dark ones and lured Nitian Erxing's brother into the domain of the gods by using his brother as a bait and then murdered him. He was also the one who issued the punishment to Shi Xing. Later on he uses the war against dark ones as a mean to dispose Tian/Hei Long and regain his powers from 100,000 years ago turning back into Pangu. After that, he once again invaded the dark one's new city in order to annihilate them, all the while planning to eliminate all current gods for being created from ancient humans.
  • Final Fantasy: Legend of the Crystals: Ra Devil is a malevolent cyborg who seeks to become Deathgyunos, the God of Oblivion. He stole Cid Previa's brain from his grave before murdering Cid's young grandson Mid. He then kept the brain alive and in torment to forcibly extract the knowledge of the elemental crystals that stabilize the world. Returning to Planet R two hundreds years later, Ra Devil steals the crystals, dooming the world to destruction. Setting sight on the Wind Crystal, he launches raids on Rouge Island and later the city of Tycoon. He then abducts the heroine Linaly, whose body hosts the the Wind Crystal and uses her as a battery to drain the energy of the universe and complete his transformation. After the heroes interrupts the process, Ra Devil fights them back and sadistically electrocutes Prettz and Rouge in front of their friends.
  • Fire Force: The seemingly cheerful and upbeat Company 1 lieutenant, Rekka Hoshimiya, is in truth a deranged member of the White-Clad who has been turning countless of innocent people into Infernals; most of whom are children whom Rekka was experimenting on to find a suitable host for the Pilot's Light. Rekka would manipulate his subordinate, Tamaki Kotatsu, into bringing him a group of children and a mother to a building where he incinerates the mother before injecting her son, Nataku, with an Infernal Bug; when Nataku becomes a suitable host for the Pilot's Light, Rekka decides to experiment on the rest of the children anyway and frame Tamaki for his crimes. When Tamaki tries to stop Rekka, he attempts to beat her to death. After Shinra Kusakabe saves Tamaki and battles Rekka, a frustrated Rekka uses his powers to burn down the building to kill Shinra, Tamaki and the children.
  • Flame of Recca:
    • Kōran Mori is a hideous millionaire who believes he can do whatever he likes thanks to his wealth, and desires invincibility and immortality in order to enjoy his wealth forever. To this end, Kōran abuses his adopted son, Kurei, having killed Kurei's lover Kurenai, and blackmails him into service with a bomb inside Kōran's own wife—Kurei's loving adoptive mother. Kōran runs brutal underground fighting rings that routinely result in horrible deaths, and manipulates fighters into Training from Hell where their loved ones die, while he employs multiple psychotic murderers and uses them to kill innocents. After Kurei loses the tournament, Kōran reveals he created an Opposite-Sex Clone named Renge, after dozens of failed attempts led to tormented clones being either killed, or emotionally abused by Kōran for being "failures", and attempts to detonate the bomb in his own wife, gleefully declaring he will destroy whatever Kurei loves. After achieving immortality, Kōran becomes a Humanoid Abomination whose desires for food and sex have "merged," which he satisfies by raping and eating innocent women by the dozen. Along with continuing to abuse Renge both sexually and emotionally, Kōran ends up devouring her to steal her soul and power, even as she begs for his mercy. In the end, Kōran Mori is a wholly irredeemable beast of a man who lives for nothing save his own whims and pleasure.
    • Kaima is the creator of Tendō Jigoku and, much like Kōran Mori, desires immortality to satisfy his one lust in life—killing as many people as possible for fun. It was also revealed that he created evil Madogu, mystical objects that grant special powers; the Tendō Jigoku would grant immortality—by using children. When Recca rejected his offer, Kaima took the chance to gloat that he would never give his power to anyone with redeeming qualities like Recca and then proceeded to merge with Kōran Mori, turning them into a monstrous being that satisfies their "lusts" by raping and killing women. To create their own army, Kaima and Mori butcher dozens of innocents, then turn them into their mindless zombie slaves that serve them unquestioningly. Finally, they planned to create a dystopia based on devouring most of humanity, waiting until a few are left to repopulate the Earth, then starting the process all over again for all eternity.
    • Mokuren Nagai is a Serial Killer who loves to target women with nothing less than a Slasher Smile and cheerful glee. With his power over plants, Mokuren invents new ways to kill his victims, such as impalement with branches, creating carnivorous plants to devour them or horrible torture. Mokuren convinces his former kid sidekick to let down his guard before trying to devour him with a plant as well. Gradually gaining a seething hatred for Recca after Recca defeats him, Mokuren sinks further into depravity and evil. He develops a relationship with fellow evil teammate Mikoto, only to betray and murder her the moment she's inconvenient to him, coldly saying he never loved her and defeating Recca is all he cares about. Even after his death, the narrator discusses what a monster without honor, morality or humanity he was.
  • Forest of Drizzling Rain: The first Ogami-san, though seen as the hero of old who protected the village, is in fact behind the Kotori Obake's horrific past. To satisfy his lust under the guise of punishing criminals who defied the laws of the village, the first Ogami-san created a system where their wives and children would be sold into sexual slavery, imprisoning them in a dungeon to hide their suffering from the villagers. After falling in lust with an unnamed village woman, he falsely accused her of manipulating men to commit crimes so he could slaughter her husband and son, then imprison her in the dungeon, as "punishment" for her non-existent crimes. He and his men raped and impregnated her, mocking her all the while, then killed the fetus to make her suffer even more, ultimately leading to her snapping and becoming the Kotori Obake who would eventually murder them all in revenge. Despite portraying himself as a hero working for the goodness of the village, the first Ogami-san is rightfully described by one of his descendants as being nothing but a hateful tyrant.
  • Fourteen: Grand Master Rose, the most powerful businessman in recorded history, desires eternal youth more than anything. Draining the essence of children and eventually his own clones to keep a youthful appearance, he even order kill anyone that saw his wrinkles. When the apocalypse starts, Grand Master Rose helps the world governments find and later capture the mysterious doctor Chicken George, using an actress to trick him. After capturing George despite the actress genuinely loving him, Grand Master Rose forces him to create a immortality formula claiming that he wants it for the sake of humanity, by threatening his loved ones and starving him. After George creates a functional serum, Grand Master Rose uses it and becomes a sapient mass of cells able to create humanoids later known as "Commodities", that he sells as expendable slaves. As the apocalypse continues, Grand Master Rose escapes Earth's destruction by putting his brain inside a female infant clone known as "Nobara" that infiltrates into the spaceship containing the last surviving children, using her appearance to trick guards before betraying her allies. Brainwashing the guards, "Nobara" forces the children to obey her; crushes the head of a dissenter; tortures America Young; abuses her own guards; and when the dissenters escape and she's insulted, "Nobara" orders a game of "Hide and Murder" with the male children. Planning on stealing America's body and turn the children in his own harem, Grand Master Rose risked the survival of humanity itself multiple times for the sake of his ego.
  • Fractale: Barrot is one of the highest-ranking figures of the Temple, a society which has enslaved the world to the Fractal System, and is the second-in-command to Archpriestess Moeran. By nature a perverted sociopath, Barrot is the current head of the Temple's cloning project, which has manufactured hundreds of thousands of identical clones all under the name of Phryne for the purpose of experimenting on them to see if they are worthy to become the key to restarting the Fractale System; any that do not meet the qualifications are disposed of. Barrot has defiled and disposed of these clones over and over, and fixates on one particular Phryne clone, raising the Phryne as his own daughter and subjecting her to sexual attentions. After Phryne escapes from the Temple, Barrot orders a wide search for her, fully willing to assault a village linked with Lost Millennium and pay immoral clients should they be capable of turning Phryne in. Barrot later retrieves Phryne, and forces her into a virginal check under the threat of Clain's life, and later boasts that he himself raped Phryne in order to emulate the experiences of Phryne's first body and make her suitable to become the key, gloating that she was "the finest vintage I ever matured." Barrot is narcissistic enough to view himself as the world's savior for his immoral research, and takes in any opportunity to soak in his own ego and sick sense of self-satisfaction.
  • Franken Fran's "Eternal Youth" (chapter 15): Shidou Miyako, one of Fran's employers, was a vain scientist who sought out eternal youth. In the pursuit of said eternal youth, she was shown to be very intolerant towards any doctor who failed her, and would punish them by decapitation and would steal their research on top of that for the sake of turning profits. Even when Fran successfully reversed the aging process, Shidou still refused to pay her and had her assassin decapitate her. Not just monstrous to the doctors she hired, she also had a thing for slaughtering clones of herself for the sake of drinking the juice from their eggs, killing 52 in this manner.
  • Freezing:
    • Isabella/Isabelle Lucas was recruited as a Pandora comparatively late to other Pandoras. Formerly a nurse before joining the corps, it was revealed that Isabella had killed multiple infants in her care to satisfy her bloodlust. When the attack on West Genetics begins, Isabella attacks Pandora and bystander alike, gleefully murdering everyone she sees. When one Pandora is able to give her a fight, Isabella promptly injures her Limiter partner's leg and attempts to rape him, using the life of his partner as leverage.
    • Isuzu Sawatari, one of Isabella's teammates, is a charming, friendly and sweet woman whose life is "plagued by tragedy" on the surface. Underneath this façade lies a sadistic sociopath whose MO for murder is to lure men into her bed to enrage their female super-soldier Pandora partners, so Isuzu can kill them in "accidents" or self defense when she is confronted by them. Having continued this practice with civilians, Isuzu is recruited to murder the scientist Gengo Aoi with three other Pandora criminals. Isuzu agrees to the mission in return for a guaranteed "license to kill", and shows her sadistic side by massacring multiple young Pandoras, and even kills one of her own teammates after crippling the other woman. Upon finding Gengo Aoi, whose bodyguard is her old rival Suna Yi, Isuzu provokes Suna into a fight by attempting to torture and rape Gengo so she can finally slaughter Suna in a straight fight.
    • The wicked High Priest of El(u)ka, Ibanyle, abuses the very balance itself for his own pleasure and hedonism. With the balance thrown out of whack, Ibanyle torments countless souls and fuses them into tortured Nova so he may experience his world's Pandoras, or Rounders, fighting them, while also taking advantage of his status as one of the few males around to keep a harem and engage in frequent orgies, while expressing a desire to rape and abuse his world's Satellizer. Attempting to have Kazuya Aoi gang raped by his concubines and expressing glee when he learns that Earth's destruction thanks to his carelessness can only help preserve Elka, Ibanyle, upon putting down the rebellion by his consort Maria, declares he will turn Maria into an abused concubine, caring only for his own pleasure and power.
  • Fukashigi Philia: Isumi Yuunagi, seemingly the kindly man who took Tasuku in after the death of his parents, is actually a murderous human trafficker whose Gift is "Will Over Memories". Before gaining his Gift, Isumi profited off human misery and is chronologically introduced trying to strong-arm a man named Sentetsu into selling his stepson to be trafficked to pay off the debts Isumi has forced upon him. A violently possessive father of his only child Yusuzu, Isumi slaughters a kid, Tasuku, and his entire family for being nice to Yusuzu during a rainstorm. Tasuku's Reality Warping sister Nao brings Isumi back with his Gift, which he promptly uses in tandem with Tasuku's gift-—rewinding time-—to brainwash Nao and a resurrected Tasuku as his slaves, murdering Tasuku over and over and over again while forcing Tasuku and Nao to enjoy it. Even when he's finally killed, Isumi tries to overwrite the personality of his killer to replace it with his own, and from there brainwashes Tasuku into remembering Isumi as his kindly parental figure. Isumi is monstrous even to Yusuzu, using his powers to curse everyone who talks to his daughter to forget her, and even attempting to stab her to death when she ultimately foils his plans.
  • Full Metal Panic!: These two psychotic members of the counterintelligence Amalgam organization are a cut above for cruelty:
    • Gauron, aka Mister Iron, is a brutal mercenary and the Arch-Enemy of protagonist Sosuke Sagara. Having killed all of Sosuke's comrades in a war-torn country, Gauron also repeatedly attempts to force himself on the minor. In present, Gauron shows his brutality on missions he is assigned to, killing subordinates for questioning him, hijacking an airliner while threatening the high school passengers, and kidnapping one passenger to subject her to painful experimentation. Returning later working as a nuclear Arms Dealer, Gauron happily slaughters Sosuke's squad trying to stop him and goes on to hijack a submarine, intending to fire its powerful missiles lest his enemies give in to his demands. Corrupting two twin teenagers into following his twisted will, Gauron uses them to target Sosuke and his Love Interest and even when lying completely immobilized, tries to draw Sosuke into one final trap to kill them together.
    • The Second Raid anime: Mr. Gates, aka Mister Kalium, is assigned to the head of Amalgam's Execution Squad and is a lunatic who kills his own followers for any slight or just to make a cruel joke. Attempting to ambush the heroes, Gates targets a public place, uncaring for the innocents caught in the way. Sexually depraved as well, Gates holds teenage twins Yu Fan and Yu Lan under his thumb, possibly subjecting them to assault, and when one is killed, uses her body as a puppet to viciously mock the surviving sister.
  • Fushigi Yuugi: The Emperor of Kutou is a draconian ruler who leads his armies on campaigns of extermination and conquest, having done so to Nakago's village where Nakago's people were slaughtered and his beloved mother raped by the Emperor's soldiers. Seeing potential in Nakago after his power allowed him to slaughter the Emperor's soldiers, the Emperor opted to turn Nakago into his own lethal weapon to cause more bloodshed. Worse still, the Emperor also turned the boy into his own personal Sex Slave after being captivated by his beauty, warping the mind of the child who would become the series's Big Bad.
  • Future Diary: Funatsu, though a minor villain, caused one of the most horrific events of the series. Once a member of a peaceful cult based around a young girl, Tsubaki Kasugano, who allegedly had prophetic powers. Funatsu killed her parents when they planned to disband the cult, fearing losing his power. Becoming the de facto head of his reformed cult, Funatsu allowed the members to rape Tsubaki regularly, possibly taking part himself, and drugged her to keep her defenseless against their constant assault. So intense was Funatsu's cruelty to Tsubaki that she went insane and began plotting to destroy the world.

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