The protagonist, whose name and sex is input by the player, but defaults to Takuto (Male) and Shiki (Female). When they were younger they were enthusiastic about the Digital Monster virtual pets, and became the runner-up in the Digimon national competition. Those days are long behind them though, and now they're busy studying for exams and participating in club activities.
- Canon Name: Both characters have official names: Takuto for the guy, and Shiki for the gal.
- The Chosen One: It's implied by Mirei that the Digital World itself chooses who enters it from the outside world, which includes the protagonist and the other humans s/he meets. In particular, the protagonist, Kouta, and Himari, as well as Shoma, were all participants in a local Digimon tournament where they all managed to get to the semifinals.
- Distinguishing Mark: Takuto/Shiki are the only humans that have bits of pixel data flaking off of them while in the Digital World: Takuto's coat sheds blue, while Shiki's hood drops off pink. This ends up giving the protagonist similarities to Shoma, whose right eye bleeds red pixels, not to mention that he's the only other character that has two Digimon partners like the protagonist.
- Goggles Do Nothing: For some reason they have googles around their neck, but are never seen putting them on. True to classic Digimon tradition in the anime.
- Hello, [Insert Name Here]: Despite having official names, you can choose to rename the protagonists before you start. Other characters never refer to you by name in spoken dialogue, referring you as "that/this Tamer" or "You" most often.
- Heroic Mime: Played with. They speak in the intro, during battle and when you interact with your partners. But in the rest of the game, they never speak and you rarely hear their inner thoughts. Amusingly, this also applies to their partner Digimon, who have voices in the opening as WarGreymon and MetalGarurumon, but revert to being voiceless (barring the generic sentences and the Voice Grunting) after they are reborn.
- Male Gaze: Shiki's rear gets this, both in the picture that comes up when you boot the game, and within the game itself should you choose to use her, since you'll mostly be seeing her from behind anyway.
- Mechanically Unusual Class: Invoked by the game itself. There are repeated comments by various characters regarding the protagonist's ability to have two partner Digimon at once.
- Ordinary High-School Student: Outside of finishing in the top four of a Digimon tournament, the player characters aren't noted for anything else. The game even begins by showing them picking up their Digimon V-Pet game while in the middle of studying.
- Pink Girl, Blue Boy: Takuto has a blue tuft in his hair, while Shiki has a pink streak in her ponytail. The color of their goggles match this as well, and in their character artwork Shiki has Piyomon as a Distaff Counterpart to Takuto's Gabumon.
- Purely Aesthetic Gender: The two are treated as interchangeable on the official website, in press materials, and within the game itself.
- Voiced by: KENN (Hirose Kouta), Yusei Oda (Yukimura)
A Tamer who joins the protagonist in the digital world along with his Digimon partner, a Guilmon he named Yukimura. He's a friendly guy who wants to do his best to help out the Digital World and hopefully find a purpose in life.
- The Ace: Kouta was actually a very successful student and athlete at school, which makes his initial failings in using the Digital World to find more of a purpose hit him harder than he's used to.
- Badass Baritone: The English voice given to Yukimura is this, especially once he's managed to evolve into Gallantmon.
- Can't Catch Up: Kouta feels this compared to his friends, so he stays in the village because he feels useless. He gets over it.
- Heroic BSoD: Kouta gets this after being defeated by a Machinedramon.
- My God, What Have I Done?: Kouta, in a desperate attempt to overcome his own fear of falling behind the others, forcibly trains Yukimura so hard that the Digimon actually digivolves into SkullGreymon, in a fashion almost exactly like Taichi's situation in the original Digimon Adventure upon obtaining his Crest of Courage. After being defeated, Yukimura reverts into an egg, leaving Kouta wallowing in self-pity until Mameo snaps him out of his funk.
- Nice Job Breaking It, Hero!: Aside from the regular breaking of causing Yukimura to become a SkullGreymon, it also gives Tsuzuki the inspiration to come up with Ultimate Altered Digivolution for the final battle.
- Suicidal Overconfidence: Kouta briefly gets this when Yukimura Digivolves into Growlmon (a Champion level Digimon), and proceeds to charge right into a rampant Machinedramon, only to get wiped out instantly.
- Vocal Dissonance: Yukimura, who's first met as a Guilmon, has a deep voice and a mature attitude. Players who were used to Digimon Tamers's more childlike Guilmon were taken by surprise once Kouta's partner first spoke.
- Voiced By: Nao Touyama (Oofuchi Himari), Yuka Tokomitsu (Rikka)
Another Tamer forced into the Digital World, alongside the protagonist and Kouta. Out of the three, Himari's the one who wants to return to the real world the most. Her partner is Rikka, a Salamon.
- Ambiguously Brown: For whatever reason, she's a little darker skinned than the other human characters.
- Break-Up/Make-Up Scenario: Himari and Rikka have a bad falling out and split up, leaving it up to the player character to help make things right.
- Cannot Spit It Out: Despite repeated questioning from Rikka, Himari appears to have trouble telling her partner why she's becoming more and more obsessed with going back home. This ends up causing friction between Himari and Rikka, and almost leads Rikka towards becoming another infected Machinedramon.
- Cat Girl: Played With. Himari's physical appearance kind of gives off a Cat Girl vibe, including a hairstyle that can give off the impression of cat ears, as well as having a Cat Smile and a Cute Little Fang, but she's all human. The fact that she has a partner who can digivolve into the cat Digimon, Gatomon, only drives this further.
- Cat Smile: Himari has a downplayed version of this as her default expression.
- Cool Big Sis: She's the oldest of her sisters, who are only in second grade. She takes care of them since they don't have a mom, and her worry over them is why she wants to return home as soon as possible.
- Cute Little Fangs: Sports one to add to her Cat Girl-lite motif.
- Jade-Colored Glasses: Downplayed. Himari's usually immediately distrustful of new folks, and it sometimes makes her jump to conclusions about others (such as the first meeting with Mameo). She also doesn't like to waste time, often requesting for others to get to the point quickly. This softens up after she tells Rikka the truth about why Himari was so desparate to get home.
- Missing Mom: Himari and her sisters live without a mother, so Himari takes care of her younger sisters.
- My God, What Have I Done?: Himari becomes distraught after she nearly loses Rikka to the Machinedramon virus, right after telling Rikka that the Digimon essentially matters less to Himari than going home does. Once her partner is rescued, Himari finally explains to her why she wanted to return to the real world, which was to get back to her younger sisters, whom Himari believes are struggling without their big sister.
- Poor Communication Kills: Himari's inability to tell Rikka the truth about her home situation leads to Himari nearly losing her partner.
- Ship Tease: Regardless of gender, Himari tells the player that she feels like she always wants to be by their side after saving and reuniting her with Rikka.
- Voiced By: Kenichi Suzumura
The protagonist of the original Digimon World, now an adult, who is still trying to sort out Analogman's curse. He uses the alias "Mameo", a nickname given to him by Luche from the Mamemon on his hat.
- Badass Teacher: He's Shouma's homeroom teacher.
- Canon Name: Averted; the official site refers to him only as "???", and he's only known by the "Mameo" alias for the duration of the game, leaving it unclear to what his real name is. This is most likely since the protagonist's name was player-selectable in the original game (although Western circles give him a Fan Nickname of "Hiro").
- Hero of Another Story: He's saved the Digital World once before. He was trying to save it this time, but his partner got infected with the BH virus, and became stuck as an egg.
- Previous Player-Character Cameo: The game all but directly states that he's the same protagonist from the original Digimon World.
- Screw This, I'm Outta Here!: After getting accused of being a mole, he leaves Floatia in a huff. It's an act to draw who everyone suspects of being the actual mole out.
- Took a Level in Badass: Compare this cute little kid to this.
- Voiced By: Sora Amamiya
A young girl that has lost her memories. She carries around a Numemon plush and is otherwise a chipper little girl.
- Artificial Human: She's a "Digital Human" created in the Digital World, making her more akin to a Digimon than an actual human.
- Cheerful Child: While she has occasional bouts of sadness at times, Luche's default personality is one of happiness and innocence. Her only wish is to be useful and to help out the protagonist and their friends in saving the Digimon of the world.
- Foreshadowing: She gets hungry and tired at different points in the story, which the humans from the real world don't experience, hinting that Luche may not be from the real world herself.
- Girls Love Stuffed Animals: Carries around a large plush of a Numemon (a slimy Digimon that attacks by throwing poop, and sometimes is known to eat poop), of all things. Which turns out to be where the BH Virus was spreading from.
- Hero Worship: Becomes pretty fond of the player character after witnessing their exploits.
- Laser-Guided Amnesia: When you first encounter her, she laments not being able to recall recent events, though she seems to remember enough to give you your next lead.
- The Mole: Subverted. She's initially found out to be leaking information to Shoma and his followers, leaving Mirei and Mameo to assume she's a traitor working with Shoma, but after Mirei investigates Luche's body, she realizes that Luche was completely unaware of her role in Shoma's plans and was just a pawn used to further his goals.
- Unwitting Pawn: She's used by Shoma to spread the BH Virus around Floatia. When Luche finds out, she's devastated.
- Was Once a Man: Inverted. She's a human who used to be a Digimon. Shoma's old partner, in fact.
A young woman who assists the heroes through digital dimensions. She mostly appears as a hologram of some sort. Mirei first appeared in Digimon World Re:Digitize.
- Intercontinuity Crossover: Hails from Digimon World Re:Digitize, where she was one of the major characters.
- Opt Out: Not that her incorporeal nature means she's much help anyhow, but she refuses to get involved in Jijimon's EX Quest because it's too disgusting for her.
- Smart People Wear Glasses: Is significantly more knowledgeable about the situation at hand compared to the others, and is the fourth of the quartet of intellectual NPCs that assist with saving the Digital World (the others being Jijimon, Taomon, and Mameo).
- Took a Level in Kindness: Not that she was ever particularly mean, but compared to her cameo in Digimon Story: Cyber Sleuth, Mirei's a lot less cryptic and sarcastic here, though that may be because there's more she can do in this world compared to her "between limbo"-like existence in Cyber Sleuth.
A young man in a black coat, whose motives are as shrouded in mystery as he is. Like Takuto/Shiki, he has two Digimon partners, Kuzuhamon (a blue/black version of Sakuyamon) and Gaiomon/Samudramon, a samurai dragon Digimon who's said to be a variant of WarGreymon's species.
- Big Bad: Turns out to be the cause of the Machinedramon plague, the creator of the BH Virus, and the one who used Luche as a mole to spread the virus to the Digimon in Floatia. He wants to tear down the walls of the parallel worlds and sow chaos.
- Blood Knight: Samudramon, who loves fighting so much that he'll never fight anyone he deems isn't strong enough to face him.
- Brainwashed and Crazy: Became possessed by Analogman's soul after he discovered the Singular Zone.
- Cheaters Never Prosper: Played With. He did cheat to win the tournament against the player, but lost his partner and felt awful about it as a result.
- Chekhov's Gunman: He's mentioned way before he shows up. He also appears, not identified by name, after Yukimura is defeated at MOD Cape.
- Distinguishing Mark: He has the "bleeding pixels" trait that the protagonist has: his are red, and come from his right eye.
- Dub Name Change: Gaiomon's name was changed to "Samudramon" in the dub of this game, despite having his original name back in Cyber Sleuth.
- Evil Counterpart: To the protagonist. Not only does he share their Distinguishing Mark, but he also has two Digimon partners who are very loyal to him.
- Evil Is Hammy: Largely of the Cold Ham variety, but he's definitely very smug and self-assured with every line.
- Evil Is Not a Toy: He wanted to try and create the ultimate Digimon, to replace his lost partner, and wound up possessed by Analogman, nearly destroying every Digital World as a result.
- Goggles Do Nothing: Wears a pair on his neck.
- In the Hood: Shoma's first appearance has his face obscured by a hood.
- Large Ham: Samudramon, who constantly yells a lot of what he says.
- My God, What Have I Done?: Once Analogman's evil leaves him, he's horrified about the damage he's inflicted, and especially what he did to Luche.
- "You!" Exclamation: On seeing Mameo. And then he refers to the older Mameo as "that brat who beat me before", because it's actually Analogman speaking through him.
- Zipperiffic: Has a partly undone zipper connecting the collar to the rest of his jacket.
A Mega-level Digimon who resembles an old man. Is the leader of Floatia and the one who requests Takuto/Shiki with help rebuilding it. His hope is to make Floatia the last bastion against the Machinedramon plague.
- Cool Old Guy: Compared to Taomon, Jijimon tries to be one to the humans, particularly towards Luche, though he sometimes pulls a Not Now, Kiddo on her, which annoys Luche.
- The Mentor: Serves as this for the first part of the game, doing his best to help the player out while working to rebuild the town and fight against the Machinedramon.
An Ultimate-level fox Digimon who resides in Logic Volcano. At first he takes an observer role during the Machinedramon plague, until humans arrive at his doorstep and request his assistance. He assists Jijimon and the others in combating the misfortune happening in the Digital World.
- Big Damn Heroes: He shows up to save the player if they finish Doumon's quest and become trapped, though not without some snarking at their expense.
- Crossdressing Voices: Sounds like the Digimon Tamers's Renamon in the English dub. This is evidently done more as a Shout-Out, as the game still considers Taomon male and ignores how he sounds. At one point, Kouta says that he hears a voice coming from the other side of a portal, stating that it can't be Taomon's since it's a woman's voice.
- Deadpan Snarker: Always keeps his cool, and never misses an opportunity to snark at others, human or Digimon.
- Grumpy Old Man: While his age can't truly be discerned, he's an old friend to Jijimon. He also tends to be rather condescending towards everyone at first, mellowing out to simple grumpiness as the story progresses.
- She's a Man in Japan: Averted. Despite having a female voice in the English dub, Taomon is still male.
Omegamon Zwart D / Noir
A black-clad, decrepit-looking version of Omegamon. Zwart D often appears in areas where the Machinedramon show up, but its motives are unclear. It's considered to be one of the most powerful Digimon in the Digital World.
- Always a Bigger Fish: Titamon puts up a fight when first met. Omegamon Zwart D shows up after he's defeated and kills the 'mon in one shot.
- Brainwashed and Crazy: Zwart D was apparently one of the first victims of the BH Virus, resulting in it acting as little more than a crazed warrior.
- Dark Is Not Evil: Despite its scary appearance, it's implied that Zwart D was always the Digital World's Enforcer, even before the events of the game caused it to seemingly go berserk.
- The Dreaded: Appropriate, given that Zwart D is the Digital World's Enforcer, tasked with deleting and destroying all malignant data in the world.
- Evil Counterpart: Appearance-wise, it's this to the original Omegamon. Not only does it sport a more sinister look than even the other Omegamon Zwart had, but it's also leaner, spikier, wears a black cloak, and has several red eyes on its body.
- Eyes Do Not Belong There: It has an extra red eye on its chest. Additionally, the WarGreymon and MetalGarurumon heads on its arms have menacing bright red eyes that stare out of the "masks".
- Lean and Mean: Omnimon already has an improbably thin build. Omegamon Zwart D takes it even further, having noodle-thin proportions.
- One-Winged Angel: Tsuzuki makes it digivole into Omegamon Alter-B for the final battle. Afterward, it sticks.
- The Quiet One: Even after being freed from the BH Virus, Noir still doesn't say much.
- Red Baron: It's usually referred to as the Enforcer by anyone aware of its existence.
- Red and Black and Evil All Over: Compared to the original Omegamon (mostly white with blue and orange accents) and Omegamon Zwart (mostly black and gold, with red accents), Zwart D sports a black and red color scheme all over its body, and acts as an antagonist throughout the game.
- Screaming Warrior: Zwart D's dialogue involves little speaking and tons of screaming.
- Too Many Belts: Zwart D's entire body is covered in belts and bandages.
An unpleasant Mega-level Digimon working for the Big Bad, met at the Server Tower.
- Dem Bones: Has it as a motif. It uses bones as armour, and has a sword made from a SkullGreymon.
- Dropped a Bridge on Him: Titamon's introduced as a major threat, gives a long speech, and after being beaten Omegamon Zwart D shoots it in the face, with MetalEtemon confirming it died afterward.
- A God Am I: Averted. It dismisses the idea of gods, and says it wanted to be a destroyer of gods.
A metallic monkey working for the Big Bad, seeking to become one of their top lieutenants. Nowhere near as competent as he thinks he is, but still dangerous all the same.
- Beware the Silly Ones: After getting caught in Bony Resort, he manages to yell loud enough to summon Omegamon Zwart D.
- Elvish Presley: As with the Etemon of Digimon Adventure, the English dub has him speaking a la Elvis.
- Everything's Better with Monkeys
- Large Ham: Especially with his accent in the English version.
- You Have Outlived Your Usefulness: At the end of Chapter 3, Kuzuhamon murders him for being a liability.
A hyperactive teenager in a hoodie who comes from the same world as Mirei. Her Digimon partner is VeeVee, an UlforceVeedramon who's also a member of the Royal Knights.
- Cloud Cuckoolander: Rina has an odd personality, exemplified by her side mission: she first tasks you to gather an extremely easy-to-find mushroom and rewards you with the same ones you found for her. She then asks you to find three rather rare healing disks, which, if you took her quests as early as possible, you won't be able to get until close to the end of the storyline. However, that's about the worse that it gets in this game.
- Cute, but Cacophonic: Rina's dubbed voiced is extremely high-pitched, probably to highlight her excitable nature.
- Foolish Sibling, Responsible Sibling: This is the dynamic Rina has with her Veemon, though it's not shown as well as it was in Cyber Sleuth.
- Heroic Mime: Unlike his appearance in Cyber Sleuth, VeeVee doesn't have a voiced line during Rina's sidequest, though he does make a quip or two during it. He speaks when he and Rina reappear, though.
- Ms. Fanservice: If only because of the way she's dressed. She leaves her hoodie unzipped, revealing nothing but a bikini top covering her chest.
- The Bus Came Back: After leaving at the end of her first quest, she returns a great deal later.
- Verbal Tic: For some reason, she's developed a habit of verbally mimicking a drum roll, but only in Japanese. The English script just has her say "Drum roll!" instead.
Blackie and Blackasaurus
A pair of black-coloured Digimon who show up at numerous points, tell the player about the location they're at, and then attack them.
- Determinator: To their credit, even after getting beaten into the ground, they always have the energy to get back up again.
- Those Two Guys
- Took a Level in Badass: They start off as a BlackAgumon and a BlackGabumon, become a BlueGreymon and BlackGarurumon offscreen, digivolve into Virus MetalGreymon and BlackWereGarurumon in their second encounter, become BlackWarGreymon and BlackMetalGarurumon off screen and then fuse together into Omegamon Zwart.
The leader of the Meat forces in the Ohguino Wastelands, who went missing during the war
- Heroic Willpower: Manages to push his way into digivolving to Burst Mode.
- Horrible Judge of Character: ShineGreymon trusts Chaosmon. Chaosmon, who canonically is a walking glitch that should never have been. Surprise, Chaosmon turns out to be manipulating him.
- Sealed Badass in a Can: He was captured by Rosemon, who used him as a battery.