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Examples:

  • The Disney's One Saturday Morning block that used to be on ABC. They advertised it as "the best thing to happen to weekends since... Saturday!" and sang that it was like "five hours of summer once a week" in its theme song. But most of the shows on the block were cartoons that took place almost entirely at school, something kids clearly don't associate with Saturday or summer. Court dates are not easily associated with summer either.

  • 3Below: When the series begins, Krel hates Earth and is eager to get back to Akiridion-5, while Aja takes advantage of the situation to run away from her royal responsibilities and is eager to experiment life as a normal person. By the end of the series, both of them have gone through enough Character Development to choose the other’s initial desires; Krel decides to stay on Earth because he considers it his new home and wants to remain with his human friends, while Aja goes back to Akiridion-5 to serve as queen and rebuild it after Morando’s coup.
  • In The Amazing World of Gumball:
    • The pest control agent is a cockroach.
    • In "The Nest", after being mauled by a little kitten, Gumball says "And that's why I'm not a cat person" which he literally is.
    • In "The Boredom", Gumball and Darwin go in search of exciting things to do or see, but end up missing all of them because of their obliviousness of their surroundings.
    • Played straight as a joke and an excuse at the end of "The Copycats", where Gumball and Darwin say they can't be replaced, even though their voice actors have been multiple times due to puberty, including this very time.
  • American Dad! has a brief example of historical irony:
    (After a lady gives a speech on how alcohol killed her teenage daughter)
    Principal Shepherd: Thank you Mrs. Holiday. Your last name is very misleading given your tragic circumstances.
  • Avatar: The Last Airbender:
    • Avatar: The Last Airbender:
      • The whole plot can take place because of cosmic irony on Aang's part. Because of the pressure of having to fulfill his destiny as Avatar, he ran away from home to escape the responsibility and accidentally froze himself in an iceberg for 100 years. Because of this, he ends up the Sole Survivor of the Air Nomads when the Fire Nation kills them all in an attempt to kill the Avatar. Thus, because he ran away from his fate, he accidentally ensured that he would actually live to fulfill it.
      • Despite it being implied he was The Unfavorite to his father Azulon, Ozai is the son who is most like his father, both being Abusive Parents and the most powerful benders in the world. And both, despite being strong leaders, don't care for the people of their nation, being more interested in taking over the world.
      • In the short "School Time Shipping", Aang, Zuko, Jet, and Haru all compete each other to take Katara to the school dance. In the end, Katara goes with the Blue Spirit, Zuko's alter ego, saying that she "preferred the mysterious type." "I did NOT see that coming," says Zuko as Katara and the spirit walks off into the sunset.
    • The Legend of Korra:
  • In Batman Beyond: Return of the Joker, the Joker does not consider Terry a worthy Batman, thinking him as some wannabe pretender. Terry is actually Bruce's biological son and thus, the true "heir" to Bruce's mantle as Batman.
  • Big City Greens:
    • In "Backflip Bill", despite Cricket wanting to prove Gramma wrong about Bill, he ends up becoming Gramma and mistreating him.
    • Two of them in "Chipocalypse Now". First, in spite of Chip wanting to run the Greens out of Big City, he ends up getting run out himself when the mayor bans him. Immediately after, Tilly cheers that their home is saved, but Chip is not done with them yet and this doesn't mean the Greens themselves are safe from his wrath.
  • Cellbound has an example of tragic irony. The prisoner is making preparations to escape jail and makes some small talk in order to quell the warden's suspicions, including a random mention of an "anniversary", thus prompting the warden to remember his forgotten wedding anniversary and run off to buy a gift for his wife. The gift? The TV inside which the prisoner intends to smuggle himself out.
  • Once on Chip 'n Dale: Rescue Rangers, Chip, Dale, and Monterey Jack (two chipmunks and a mouse) use catapults to throw themselves from the police station to their headquarters. The catapults are built from mousetraps. Additionally, they appear to have been built by Gadget who's a mouse herself.
  • Cow and Chicken was accused of being a ripoff of The Ren & Stimpy Show. Series creator John K. stated that Cow and Chicken is actually his favorite cartoon from the 90's. It's practically the only one he does like.
  • Drawn Together:
  • The Dragon Prince: Lord Viren wanted to end the war against the elves because he thought humans could never flourish while they were around. The war between them does end, not because one side won, but because both sides are starting to join together when he turns out to be a bigger threat.
  • One episode of Duckman has the title character buy a security system to keep his house safe. The night after it's installed, a pair of burglars drive by, see the sign for the security company, and realize that somebody lives there. They look up the system's technical specifications and successfully rob Duckman's house. Thus, the security system not only fails to protect Duckman's house, it actually leads to it getting robbed.
  • DuckTales (2017):
    • Each of Scrooge's traits that the triplets expressed admiration for in the first episode become sources of anger towards him upon learning the truth of Della's disappearance:
      • Dewey, who looks up to Scrooge for his daring and adventurous personality, is furious that Scrooge built the incredibly dangerous rocket Della took to outer space.
      • Huey, who admires Scrooge's intelligence and wisdom, can't believe Scrooge didn't account for the dangerous variables of the cosmic storm and order Della to turn back instead of trying to guide her through it (although given Scrooge's comment that she was stubborn, it's implied he did try to talk her down only to be ignored).
      • Louie, who always held Scrooge's vast fortune and Pooled Funds in esteem, lashes out at him for seemingly not using them to fund more ships to go up to space and find her (though it turns out Scrooge actually did do this).
      • A double dose of irony shows up at the end as the flashback showed all three were wrong to lash out at him; Scrooge spared no expense and sent entire fleets up into space to look for Della, sitting by mission control the entire time. He had to be physically dragged away screaming and kicking by his board members when he nearly bankrupt himself and the company. And he doesn't get to tell this to the boys due to his anger.
    • Hummingbirds are known for being hyper, due to their diet of sugars. Violet is easily one of the least hyper characters in the show.
    • Donald graduated from college with a major in Public Speaking, despite being, well, Donald Duck.
    • Lena, a Living Shadow, ends up gaining a light-themed Super Mode in "The Phantom and the Sorceress!".
  • In the Ed, Edd n Eddy episode "All Eds Are Off," when Ed won the ending-habits-bet and decided to spend the prize money on gravy.
    Eddy: [angry] Oh come on! You're gonna spend the money on more gravy?
    Edd: [happy] Irony, Eddy. Look that up in the dictionary.
    • Another case pops up in "Floss Your Ed", after Eddy spends the entire episode trying to get Ed's last baby tooth to get cash from the Tooth Fairy to get jawbreakers. Instead, he ends up knocking out one of his own teeth instead. When Edd asks him if he understands the irony of the situation, Eddy says "The one where we forget about Ed's tooth and cash in mine?", only for Edd to point out that the real irony is that he spent all that effort to get a jawbreaker now, when the Tooth Fairy only appears and night, when you're asleep, and that the candy store will close in half an hour.
  • Family Guy:
    Fireman: It looks like the cause of the fire was these stress relief candles.
    Chief: Huh. Irony!
    • In "A Very Special Family Guy Freakin' Christmas", Peter has a trick fire extinguisher which shoots flammable paper snakes instead of foam, thereby exacerbating the problem. Brian falls victim to this potentially Deadly Prank and afterwards confronts Peter about it:
      Brian: Who the hell buys a novelty fire extinguisher?
      Peter: I'll tell you who! Someone who cares enough about physical comedy to put his whole family at serious risk!
    • In the episode "Peterotica" this happens:
      Kool-Aid Man: (after a car crashes into his house) Wow. From the other side, that's kinda annoying.
    • In "Da Boom", the Griffins get kicked out of the post-apocalyptic town they founded when Peter spends the peoples' tax money on guns. After the people burn the guns in a bonfire, Stewie's mutant spawn attack them and they're no match for them without the guns.
      Man: Hey Bob, remember the other day when you were asking me what the definition of irony was, and I said—(gets attacked by an Octo-Stewie)
  • In the Futurama episode "The Devil's Hands are Idle Playthings", the Robot Devil throughout the episode describes the results of his schemes as ironic, to which Bender kept correcting him: "It's not ironic; it's just coincidental!" or "It's not ironic; it's just mean!" Only at the episode's musical ending does Bender note that the Robot Devil has finally executed the dictionary meaning of the word: "The use of words expressing something other than their literal intention! Now THAT... IS... irony!"note 
  • G.I. Joe uses a number of weapons and vehicles in their war against Cobra. One of these is the Dragonfly attack helicopter whose design is based on the real life Bell AH-1 Cobra.
  • The Hollow: Death horse, Mr. Jeepers, is clearly at the last legs of his life, refusing to eat or drink and looking very sick and exhausted. Those who work with animals or have pets would realize that this is the time to euthanize this animal so that they wouldn't have to suffer any longer. His fellow horsemen mock him for this.
  • The Iron Man: The Animated Series episode "Cell of Iron" sees irony discussed between Tony and H.O.M.E.R. throughout the episode, albeit with H.O.M.E.R. mostly learning about sarcasm specifically and only learning about tragic irony at the end.
  • Jackie Chan Adventures:
    • Tohru hates fish, yet is from Japan, where fish is a very common ingredient and dish. Notably when he visits a sushi restaurant, the only thing that doesn't have fish that he orders is Miso soup.
    • The opening sequence shows Jackie getting his hands on the Dragon talisman. Within the show, the Dragon talisman is the only one of Shendu's 12 talismans that the heroes didn't outright get (the heroes initially got the Sheep talisman until Jade accidentally used it and the Dark Hand swiped it from her).
  • In Jimmy Two-Shoes, Beezy exclaims that something is ironic. He then pauses and wonders if he actually knows what irony is. Later in the episode, he's still wondering if he got it right.
  • Jonny Quest. In “The Robot Spy,” Benton uses the parapower ray gun (which interferes with machinery) to take down Zin’s aerial drone. In “The Fraudulent Volcano”, Zin repays the favor by shooting down Benton’s plane with his own similar beam weapon.
  • Kaeloo:
    • The Growing Up Sucks themed episode ends with Kaeloo, Stumpy and Quack Quack singing a song about what a wonderful friend Mr. Cat is to them. At the moment they're singing this, Mr. Cat is running around looking for a bazooka or other weapon to kill them with.
    • As the series progresses, we learn that Mr. Cat, who despises interacting with people, enjoys being alone, and is rude and snarky to everyone he meets, is popular and well-liked by everyone, while Kaeloo, a friendly extrovert who loves everyone, is generally avoided by people because they think she's weird and annoying.
    • In Episode 184, Kaeloo takes the rest of the main four to an alternate universe called "Super Perfect Land" to teach them how to be "perfect". While there, she meets the alternate universe counterparts of Stumpy, Quack Quack, and Mr. Cat, who are so perfect and well-behaved that Kaeloo herself looks like a lazy, gluttonous slob in comparison. They tell her about how "perfect" their Kaeloo is, causing Kaeloo to feel even more insecure about her flaws. The alternate universe counterparts are actually the Stumpy, Quack Quack, and Mr. Cat from Kaeloo's own universe, who got fed up of being told that they were imperfect and wanted to teach Kaeloo a lesson. Super Perfect Land has no counterparts of the main four; the reason it's perfect is that the main four don't exist in it. Kaeloo decides that she's had enough of being "perfect" all the time, and starts swearing in public, littering, and eating junk food. Mr. Cat says that now that Kaeloo is being her true self, she is "perfect" in his eyes.
    • Kaeloo and Mr. Cat both have incredibly low self-esteem, but they have very high esteem for each other.
    • Mr. Cat is the main antagonist of the series and often torments the rest of the main four just for the heck of it, yet he is The Leader of the main four whenever they encounter a problem that the four of them need to face together.
    • In one episode, Kaeloo's friends are all out doing their own thing and Kaeloo thinks that they've abandoned her because she's not important to them. When she makes a phone call to Mr. Cat, who is at a party, the latter tells everyone else at the party that the caller is "the frog I was telling you guys about just two seconds ago".
    • When Quack-Quack notices that Stumpy's sister Violasse carries around a balloon with his face on it, Stumpy explains that Violasse was Born Unlucky and that she sees the balloon as a Good Luck Charm that will save her from danger, as if Quack-Quack was her personal "superhero", which Stumpy dismisses as nonsense. As Stumpy (who was also Born Unlucky) is explaining this, Quack-Quack saves him from falling into a pit, being hit by a meteor, and drinking poison, proving that he is indeed a "superhero" to those who struggle with bad luck.
  • The Coyote/Roadrunner Looney Tunes are cosmic irony incarnate. A good example is the time Wile E. straps himself to a motorized scooter headed for a cliff. He manages to free himself as it goes over, and just before falling, watches the scooter land safely on the other side.
  • The Looney Tunes Show: In the episode "Daffy Duck, Esquire", Daffy and Bugs pretend to have the other's lifestyle (Daffy pretends to be the responsible handworker while Bugs pretends to be the lazy and irresponsible slacker) in a gambit for former to win Tina's dad approval. Originally approving of Daffy because his "job" as a lawyer could provide for his daughter, Frank starts to prefer Bugs after seeing Daffy is a "Workaholic" who barely spends any time with Tina. Essentially, Frank wants Bugs to be Tina's boyfriend because his lack of a job means he can spend more time with Tina, unaware that's what Daffy is really like.
  • The Loud House:
    • In "Really Loud Music", Michelle and Doug refuse to let Luna perform her song entry as herself because they claim it's not "what everybody wants"; however when she sang her original entry as herself, everybody loved it.
    • In "Washed Up", Lincoln convinces Lucy to come to Lake Eddy in search of the mysterious sea monster Plessy; it's Lily who ends up discovering Plessy, not Lucy nor Lincoln, but when she tried to tell him about it, he thought she wanted to go back to the island.
  • In a Mickey Mouse Works short, Minnie becomes tired of eating the same sandwiches at picnics because Mickey can't cook. When Mickey later sees Minnie talking to José Carioca (of all people) about how he's going to prepare her a gourmet meal, he panics (thinking that Minnie wants to date José because of his cooking ability) and tries to learn how to cook. Minnie tells him that's not necessary, because she was just hiring José to cater their picnics. Cut to the picnic, and what is the gourmet food José has prepared? The exact same sandwiches that Mickey has been making the whole time. In trying to spice things up, Minnie has made things exactly same. The irony is not lost on her.
  • Molly of Denali: In "Tooey's Hero," Tooey regards the famous musher Eugene Pike has a hero, but then Tooey himself becomes a hero by the end of the episode by getting the mail to Qyah when Pike couldn't make it.
  • Moral Orel episode "God's Image" is about the city of Moralton deciding that the olive-skinned Italian-American Figurelli family aren't "made in God's image" and start enacting segregation policies exclusively against them. The whole thing is played for laughs, as not only do the perpetually-upbeat Figurellis barely even notice, but the segregation actually benefits them and hurts everyone else (such as an entire schoolbus worth of kids needing to cram into the front half while the Figurelli kids get the entire back half to themselves,) leading to other kids dressing and acting like Figurellis (also known as "figgur-lovers" or "wigurellis".) Eventually, Coach Stopframe angrily torches the Figurelli's house and the fire department refuses to put it out, which just causes the fire to spread and consume the entire town with the exception of the church and the Figurelli's second "segregation home" which is even better than the original house.
  • "One Froggy Evening". A man wants to make money off a singing frog, only the frog won't perform in front of anyone else, making financial exploitation of its talents impossible. It also contains an example of dramatic/tragic irony at the end, when the Future Construction Worker runs off excitedly with the frog. You know full well what is going to happen.
  • Phineas and Ferb: In a few episodes, in spite of Candace wanting to bust her brothers, the one who gets punished is Candace herself.
  • Pooh's Grand Adventure has Rabbit and the gang thinking they see the Skullasaurus, unaware that it is actually Pooh. Ironically, Pooh's stomach is the source of their fears so their reaction is appropriate but not in the way they imagine.
  • The Disney Wartime Cartoon "Reason and Emotion" ends with a lesson that you shouldn't let fear overcome either of those traits. But since it is a propaganda short, it is itself using fear to intimidate the viewer.
  • In Recess, Spinelli, in an attempt to keep her friends from finding out about her parents (she feels embarrassed by them), tried to lie to them by claiming her parents were spies/secret agents. In the ending of the episode, it turns out they actually are secret agents.
  • Rugrats:
    • In the episode "At The Movies" the babies end up in a movie showing two people kissing. Lil then says:
      Lil: I hate kissing movies. Nothing ever happens.
    • In another episode, Angelica believes she is a psychic. However she gets the word wrong and says "psycho" instead. So when she goes around referring to herself as "Angelica, your psycho friend" the fans wholeheartedly agree.
  • In Samurai Jack. Quoth the Scotsman, "You are the only stranger I know."
  • Scooby-Doo:
    • Given the invokedlegacy Scrappy ended up with after his tenure, you wouldn't have expected him to be a major factor in the series continuing; prior to his introduction, it was the series sticking to formula (which is typically preferred over the addition of a disliked character) that landed it with low ratings at the time. His antics, as well as other changes to the status quo, actually kept the plots fresh. Since the show remained on the air without him and later seasons incorporated the concept of plot mix-ups, most of the jokes referencing Scrappy now turn it around and say that he (or an expy of him) would have been the one to get the series canned; all the other installments added something new to the table, so what made Scrappy so special?
    • In the What's New, Scooby-Doo? episode "The San Franpsycho," the gang is in a speedboat fleeing from a great white shark:
    Velma: We're gonna make it... [shark takes a giant bite of the boat's aft] Ah, irony. We meet yet again.
  • In Skylanders Academy, while Kaos gives Spyro a beat down with the book that Spyro is trying to recover, he remarks on the irony of the situation, hesitates and asks Glumshanks if that does in fact count as irony or not.
    Glumshanks: I try to avoid that word sir, on account of the fact that nobody knows what it means.
  • South Park:
    • In "Cartman Joins NAMBLA", Kenny spends the whole episode trying to stop his father from impregnating his mother, then when that doesn't work, he tries to get rid of the unborn baby anyway. In the end, Kenny dies (again) before the baby is born, and the baby becomes him.
    • In "Good Times for Weapons", Kenny is the one who got Butters injured by tossing a shuriken into his eye.
    • Cartman's Small Name, Big Ego alter-ego "The Coon", also known as a racial slur for black people.
  • SpongeBob SquarePants
    • In "A Pal For Gary", Mr. Krabs seems oddly kinder than usual and acts as a Reasonable Authority Figure, compared to his depictions in later seasons, while SpongeBob takes several levels in both jerkass and dumbass. In the same episode, in spite of wanting to prove to Mr. Krabs that he can be a responsible pet owner by finding Gary a partner to keep him company so he's not lonely when he's away, SpongeBob ends up becoming irresponsible for the way he treated Gary throughout the episode.
    • In "SB-129", Squidward orders (present-day) SpongeBob and Patrick to stop bugging him with favors to join them in jellyfishing. But then when he travels to the Precambrian Era, Squidward gets annoyed with the Primitive Sponge and Star being Too Dumb to Live playing with a jellyfish stinging themselves over and over that he forces them to take up jellyfishing instead. It's more civil and less cacophonous.
    • In "Hide and Then What Happens?", SpongeBob spends the entire episode traversing all over the world trying to find Patrick in a game of hide-and-seek; in a huge case of irony, Patrick was at home the whole time, which was coincidentally SpongeBob's first guess which he dismissed because it would be "too obvious".
  • Star vs. the Forces of Evil:
    • In "Blood Moon Ball", Marco tries to rescue Star from the Blood Moon Ball after hearing that the Blood Moon is the moon of lovers. Star and Marco end up dancing under the light of the Blood Moon, but Star gets angry at Marco for crashing the ball and not trusting her to handle herself. She tells Marco that she just needs him to be her friend, basically telling him to back off. So it came to be quite the surprise when it turned out that Star is the one to eventually grow a crush on Marco in "Sleepover", not the other way around.
    • The Butterfly Family in general seems to run on this. In general, they look down on most monsters and anyone who don't fit their standards, with Etheria shouting at the Johansen family in "Game of Flags", "You Johansens spoiled my appetite like you spoiled the Butterfly family tree!" Not only are they allied with monsters, but their ability to turn into butterfly-like creatures technically makes them monsters as well. And they let the Magic High Commission "spoil" the Butterfly lineage by swapping out the half-monster princess with a peasant girl from Pie Island out of racial disgust. As for individual queens:
      • Lyric Butterfly wanted to be well known and remembered. Her saving a book of fashion instead of The Original Book of Spells is the reason that said book of spells was lost in a fire, meaning that she will not be remembered like her daughter.
      • Skywynne being a beloved queen was motivated by her desire not to repeat her foppish mother's mistakes. She ended up sacrificing her own happiness for the sake of her people, including making Jushtin give up his claim to the throne because male rulers wouldn't be accepted in a matriarchy like Mewni. This, despite turning out to be a much better person to be on the throne, because he was a talented negotiator who was able to make friends with monsters, such as the Pony Heads and Lucitors. On the other hand, his sister Solaria was a warmongering, racist queen who advocated for monster genocide, and was killed by the monsters in turn.
      • Poor Jushtin is filled with this:
      • His cheek markings are four-leaf clovers, which are symbols of good luck and fortune. He would have been the first male ruler in Mewni's history, although he was superseded in favor of his younger sister, Solaria.
      • His mother, Skywynne, wanted him to succeed and achieve great things in his life. He ended up being known as the only Butterfly "un-queen", whose dreams were dashed because of his gender.
      • Skywynne also wanted Jushtin to be a "mighty magic wielder" like her. He ended up with weaker magic than his female relatives' because of his preference for hanging out with his friends instead of studying, as well as having the magic wand taken away from him for being a boy before he could learn anything else.
      • Likewise, Jushtin's sister Solaria also has this:
      • Eclipsa, the notorious "monster lover", was the daughter of Solaria, Mewni's most ruthless monster hater.
      • Symbolism-wise, the sun themed Solaria was considered the worst of the Butterfly family and a representation of the darkest aspect of Mewman history. While her darkness themed daughter Eclipsa refused to follow in her footsteps, and is perceived a two-faced villainess for wanting peace with the monsters.
      • Festiva the Fun had endeavored keeping her subjects happy and content, yet she would later be incapable of so much as recognising her first daughter's depression, much less aid her in treating it.
      • Celestia the Shy:
      • She was an extremely shy and reclusive person in life, and never felt comfortable around people. But this just made people try to get close to her in order to learn her secrets, presumably because she was so beautiful and adorable-looking.
      • The Magic High Commission erased all mentions of Meteora because of her half-monster heritage. Celena was also essentially half-monster, but since her father was specifically a Lucitor, this goes completely unquestioned.
      • Estrella the Drafted's extensive focus on art during her reign would've been seen as a sign of incompetence as a queen, but the mewmans loved her because they hated changes to the status quo.
  • Star Wars Rebels: Almost everything Agent Kallus does in the first two seasons, after his Heel–Face Turn during the Time Skip between his last Season 2 appearance (which ended with him having a Heel Realization) and Season 3. It's very interesting, after watching Season 3, to rewatch the first two seasons and compare his behaviour.
  • Amethyst and Pearl from Steven Universe bicker due to personality differences. However, a closer examination will show that they both have a similar backstory and inferiority issues, in addition to growing up mostly friendless and losing their loved one. It's probably not a coincidence Amethyst comforted Pearl after Garnet got mad at Pearl for lying to her so they could fuse into Sardonyx (which Pearl did in order to feel stronger).
  • Superjail! is a meta-example. This Bloody Hilarious show by Augenblick Studios was often compared to Metalocalypse for the extreme levels of gore and carnage. However, when the company behind Metalocalypse produced the second season of the show, since Augenblick was unavailable, the bloody contents were toned down greatly.
  • Heimlich, a villain on TaleSpin, is detailing his plan which he calls "The Heimlich Maneuver" when his henchman accidentally causes a diamond to get lodged in his throat. After he gets it out, he berates his henchman for not trying to help him. The henchman says "I was too busy listening to your Heimlich Maneuver to realize you were choking." note 
  • The Irony can be found in Team Umizoomi, where it's a show about math and 2 of our 3 main character has only four of all 5 fingers.
  • Season 6's "Rain on Your Wedding Day" (title from a lyric from the Alanis Morissette song) of Teen Titans Go! features Robin conduct a near-episode-length lecture on Irony. After the Brain is baffled by the Titans' misuse of the term, Robin declares it a pet peeve and describes verbal irony before explaining the two other forms of irony (situational and dramatic) - while encountering situationally and dramatically ironic happenings mid-lecture. How.. ironic. Literally.
  • A Thousand and One... Americas: In the first episode, when Chris presents himself to an Incan little girl (Alicora), she asks him about the meaning of his name, and Chris says he has no idea, which surprises her as all names are meant to have a meaning or origin (she then tells him that hers, Alicora, means "good grass"). The name Chris is a diminutive form of Christopher, which in turn comes from the Greek name Cristophoros, which means "bearer of Christ". The religion of Christianity was brought to the Americas by the navigators led by Christopher Columbus (original name Cristoforo Colombo), which in turn would lead to the violent end of the dominion of Incans in the Andean regions of South America. Quite an intriguing outcome that contrasts the close friendship formed between the European Chris and the Incan Alicora, especially since Chris a crush at first sight on her.
  • In Totally Spies!, Max Exterminus is a former insect exterminator who turns himself into a human-cockroach hybrid.
  • Despite the Transformers franchise's tagline "Robots in Disguise", select iterations of Earth's battle between Autobots and Decepticons make them very known, very often, to the general public. The Autobots, in particular, become celebrities at best and fugitives at worst. Decepticons don't give a slag. A few of them have the Autobots take on their adversaries while remaining as incognito as huge robots can, with only a small handful of human allies backing them up.
  • Mark Lily of Ugly Americans is a social worker for the department of integration, whose entire job is to help the various weird monsters of the setting integrate into the city. He is incredibly ignorant of them and their needs despite his well-meaning attempts to help.
  • In the What If…? (2021) episode "What if... Dr. Strange Lost His Heart Instead of His Hands?", Uatu the Watcher refuses to step in and save Strange Supreme's world, stating that his oath of non-interference refuses to let him step in and leaves Strange to his fate. However, in "What if... Ultron Won?", Uatu is forced to get Strange Supreme's help when Ultron Infinity proves too powerful, thus breaking his oath. Strange just soaks in the irony of it all.

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