If you need an addictive or psychedelic substance for a storyline, there's always one old standby: Make one up. This meshes perfectly with Speculative Fiction, but would seem completely out of place in a realistic series. Alternatively, if it's a comedy, you could get away with I Can't Believe It's Not Heroin instead. Otherwise you can resort to the potentially narmyG-Rated Drug.
Aside from a writer's hesitancy to show a beloved character using drugs, many viewers are surprised Media Watchdogs who often cracked down on any depiction of drugs (even if they were negative) for many years. Lately it's been reduced to "heavily sanctioned" at best, creating the unfortunate irony that incorrect portrayal of the effect of drugs has made audiences more liable to dismiss the true effects of drugs as propaganda.
In Real Life, these are known as "designer drugs", for people who want to get high without using technically illegal street drugs.
Often can be the Spice of Life. Not to be confused (usually) with Psycho Serum. Addictive Magic is closely related. Compare Alien Catnip when a mundane substance proves a drug to aliens.
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Code Geass has Refrain, which causes the user to relive their fondest memories, making it especially popular among the downtrodden Japanese. It's also rather important to the plot in several places.
It also seems to physically link the user into the Wired, and susceptible to its more esoteric phenomena.
Cowboy Bebop has the Red Eye, a stimulant which is sprayed in the eye and grants incredibly fast reaction times and dissociation from reality.
One episode of the classic Astro Boy has "Yellow Horse", an intravenous drug made from "Space Dust" that causes euphoria & compulsive dancing followed by horrible withdrawal pains. The gang that created it, the bizarre Phantom Club (a group of mostly space colonists dressed up in ridiculous ghost costumes), in typical over the top cartoon villain fashion, apparently intended to get the entire population of Earth addicted so they could take over the world.
A wide variety of new drugs are available in the setting of Gunnm (AKA, Battle Angel Alita), as is typical of futuristic dystopias.
An episode of Silent Mobius deals with a drug known as Dommel, which is a very powerful performance-enhancing drug... with a tendency to mutate its users into hideous monsters before dissolving into a puddle of goo. It's extracted from the body of an demon from another dimension.
Similarly, Togainu no Chi has Line, which increases strength and reduces sanity.
The Big Bad of the Fishman Island arc in One Piece uses this, as does his crew. It's called Energy Steroid, and taking one pill doubles your strength...but also shortens your life. We see the full effects at the end where they age from their prime to weak old men just hours after the battle.
From the Punk Hazard arc, we also have NHC10, a highly addictive stimulant drug. It can be used as medicine, but only selected doctors in selected countries are allowed to use it. It only takes a small daily amount of it to be addicted, and its short-time withdrawal symptoms are pain and increased aggressivity. It's dangerous to the point that the characters who were shown to be addicted to it were writhing on the ground in agony, before going completely apeshit and attacking Luffy. Oh, and said addicted characters were kidnapped children who were experimented on by the Big Bad of the arc.
Kerasine, a drug whose symptoms change with the dosage but also make people highly susceptible to suggestion, was a major plot item in Gunsmith Cats.
Watchmen had 'Katies' (from KT-28, possibly a derivative of Ketamine), a type of drug often used by the Top-Knot gangs. It should be noted that this was not so much about avoiding naming real life drugs, but establishing that culture was divergent in this reality given the influence of Dr. Manhattan. Ordinary drugs such as marijuana and cocaine are also mentioned.
In the Russian version they're called "Drunkberries".
The Batman comics give us "Venom", a highly addictive "super-steroid" which gives the user incredible strength, alertness, and agility temporarily. When first introduced, Batman himself is using it as a way to cope with his imperfections. He soon realizes he's made a terrible mistake, and must endure a horrific withdrawal before returning to normal. But Venom is most famous as the power source of Batman's enemy Bane, who wears a tank full of the stuff with tubes hooked up to his veins, giving him a constant, steady dose of Venom. The result is that he's incredibly strong (so much so that he once broke Batman's back...he got better) but totally dependent on the stuff, and Azrael eventually beat him by cutting off his supply.
In Batman Beyond a future version of Bane appears; he's now an incredibly frail invalid, his body utterly ruined by years of Venom abuse. The drug, on the other hand, had been put on the street as a performance enhancer, in convenient transdermal patches.
Marvel has Mutant Growth Hormone, or MGH. It induces a temporary genetic shift in the user, giving them superpowers. It also fucks you up good.
In Judge Dredd, there is a drug to give immortality to humans made by killing and harvesting glands of a sentient alien race, The Stookies, that have heart attacks at the slightest things (similar to fainting goats). Naturally, stookie glanding is completely illegal and people who deal in it are dealt with in Dredd's normal manner (most of them wind up dead). So do most of the Stookies he's trying to save. Stookie glands are so addictive, that the symptoms of coming off them involves rapid ageing.
In Flash and Teen Titans, one of Vandal Savage's businesses is selling Velocity-9, a drug that gives the users superspeed. And then they burn out and die.
D.M.N. in the Superman titles is a drug that turns the user into a demon. It was created by Lord Satanus.
Adam Warren's Dirty Pair universe has several fantastic drugs, this being the future filled with transhuman technology. Wardrugs are (possibly) implanted applicators that inject a tranquilizing cocktail into the blood after a serious injury. Kei gets her leg half blown off, and starts 'glanding' wardrugs immediately, which makes her pretty loopy. There is also a chemweapon called 'Proust-in-a-Can', which places the victim into a coma while they are locked into re-experiencing a distant memory.
Since Transmetropolitan is basically the adventures of Hunter S. ThompsonTwenty Minutes into the Future, there are several "future drugs" that protagonist Spider Jerusalem ingests injects and generally crams into every orifice. As noted in the Quotes section, among these is Mechanics, a nanotech drug that slowly turns your body into a cyborg system that turns addiction into a protocol.
When Spider moves into an apartment, he finds his appliances are drug addicts. Someone went to the trouble of developing a drug that an AI can have plugged into its mainframe. (Those Cool Shades? The Maker was high at the time.)
The Invisibles has the "Key" series of drugs (Key 17, Key 23) that cause people to hallucinate and mistake words for the thing they describe. Having been told he was infected with a flesh-eating virus, someone is tortured by being shown a hand mirror with a post-it saying "diseased face"; a villain drops to her knees, sobbing with regret and begging forgiveness in front of a "world's greatest dad" mug; and one of the Big Bads explodes when a flag-gun saying "Bang!" unfurls in front of him.
Marvel's 2099 line of comics in the early-to-mid '90s had quite a few examples of this:
Rapture was a legal designer drug developed by (and exclusive to) the Alchemax corporation that would be distributed to employees in order to keep them loyal to the company. A "very high-powered, mind-expanding hallucinogen," it causes the user to feel perfectly calm and collected ... unless he tries to fight the drug's effects, in which case it causes him to hallucinate wildly, "seeing monsters everywhere." It also bonds with the user's DNA in short order, becoming so addictive "you need it the way you need air to breathe." Geneticist Miguel O'Hara, who would become the Spider-Man of 2099, was slipped the drug by his boss when Miguel tried to quit the company. He tried to rid his system of Rapture by rewriting his own genetic code using a stored file of his genome which he'd been using for experiments. Things didn't go as planned, and Miguel ended up with spidery traits in his DNA as a result.
A similar drug, Rhapsody, was mentioned in an issue of X-Men 2099, in which it was revealed that the Synthia corporation secretly laced its food products with the drug, so that consumers would become addicted to eating Synthia food, at the expense of their health.
Chameleon 2099 turned out to be a drug rather than a person, which not only manipulated a user's DNA, it allowed him to shapeshift (either partially or completely) into whatever animal happened to suit the user's mindset at the time of taking the drug. Users have been seen assuming the characteristics of animals like bulls, mice, felines, and dogs. It was an Alchemax-designed drug, but "unstable even by their standards" to the point that users often die painfully from the toll it takes on their systems.
Chain is one of the most illegal of drugs in that era. In 2099 A.D. Genesis, it was revealed that the legislation on Chain had been upgraded from a "thirty-year stretch" (being physically aged by three decades) for possession to a "death penalty" for even having it on one's person. In his only appearance in the 2099 comics, the Daredevil of that era planted a dime bag of Chain on a drug dealer just to make sure the dealer never pushes drugs again. At the time, the dealer had been peddling a drug laced with "a rider chemical" that "causes communicable sterility". In short, Daredevil signed a drug dealer's death warrant for trying to "kill all birth in Downtown."
Perhaps the most bizarre example was found in X-Nation #1. The main characters, a group of teenagers living at the Xavier Institute for Indigent Children, had slipped away to a bar and try a unique hallucinogen: milk. They attached diodes to their foreheads; drinking milk stimulated their brains into producing bizarre hallucinations. But as one of them insisted, "'s really good f'r your bones an' teeeeeth."
A shot of "buz", from an early issue of Cerebus, is one hundred percent addictive and provides all the nutrition an adult needs in one day. A villain uses it to subjugate and rule his entire city.
The mutant celebrity team X-Statix had several custom drugs that helped to support their ultra-self-destructive lifestyles. U-Go Girl, for instance, took at least two different stimulants to counteract the extreme fatigue that her powers caused her. There was also a drug that many on the team used to instantly purge themselves of alcohol so that they could go straight from parties to missions. It was implied that this latter drug had terrible effects with long-term use, but since the average lifespan of an X-Statix member was only a few years at best, nobody really worried about it.
During Grant Morrison's run on New X-Men, Xavier and his staff had to contend with Hypercortisone D (or "Kick"), a highly addictive stimulant that boosted mutant abilities. Emma Frost described the high as making one feel both "angelic and violently insane for five hours."
The magic potion in Astérix is mostly just Super Serum but is played like this in a few stories where it's funnier. For instance, the druid who gives it to the villagers is named Getafix, athletes at the Olympic Games are banned from taking it, and in one story it's explicitly and repeatedly referred to as 'the dope' by a Roman trying to steal it. The official site also implies that it has some mild psychological effects, basically inducing childlike thought in people who drink it - explaining Obelix's strange personality and why even the more shrewd Gauls really enjoy beating people up on potion.
In a few issues of Knuckles the Echidna a substance called Lemon Sundrop Dandelion was hidden in hot dogs at an amusement park. After eating the dog most characters would begin tripping balls, though Charmy's friend Mello died of an overdose and Charmy himself almost did as well.
In Empath: The Luckiest Smurf, smurfnip is treated the same as pot with the attendant Marijuana Is LSD trope. A telltale way to know that someone is stoned on smurfnip is that the whites of their eyes turn green.
In the Heat Guy JYaoi fanfic "In a Different Light", there are three such drugs mentioned. All are evidently connected with Rave culture. The first is a very addictive one called "Black Tab," which can lead to extreme suggestibility and/or hallucinations. The second is called "Celestial Blue," which appears to be some hybrid of MDMA and heroin in terms of its effects. The third is called "Virgin's Blood," which is stated to be a dilute form of MDMA dissolved in a red syrup containing various aphrodisiacs, and is often taken with other drugs (such as Celestial Blue) that inhibit sexual performance.
RoboCop 2 has "Nuke," which is "injected" via disposable eyedrop vials. There was pretty much a cult based around the drug.
Star Wars: Attack of the Clones had death sticks, something which the writers of the Holonet News promo had some fun with. The Expanded Universe featured harder drugs such as ryll and glitterstim (which was, incidentally, the "spice" that Han used to smuggle for Jabba the Hutt).
The "So Beautiful, So Dangerous" segment of Heavy Metal shows two alien starship pilots getting wasted on a white powder they identify as "plutonium nyborg" and then flying home utterly stoned. "NOSEDIVE!"
Played with in Transformers when a police detective accuses Sam of partaking in "mojo", which he assumes is a designer drug. "Mojo" is the name of the family's chihuahua, and the drugs are said dog's painkillers.
Harley Davidson and the Marlboro Man has Crystal Dream "...what it is, you don't shoot it, you don't smoke it, you don't snort it. Apparently, you put it in your eyes, and it tells you lies."
Looper features an unnamed designer drug administered via eye drops. It appears to cause awful withdrawal symptoms.
The Dolph Lundgren film I Come in Peace features an alien drug "collector" who overdoses humans with stolen heroin so he can extract endorphins from them for sale off-world.
Ed Nygma's invention, the "Mind Blender"...er, the Box from Batman Forever, which allows him to suck the neural energy of everybody watching TV with the thing. Taking hits from Nygma's machine is apparently quite addictive. The Riddler himself spends hours on a stylized throne shaped like "The Thinker", jittering like a coke fiend as he sucks up more energy.
Merasha is a drug that severely disables Deryni, with nausea, dizziness, blackouts, and severely disorienting psychedelic effects on the brain that prevent the drugged person from concentrating (a requirement for the use of Deryni powers). In ordinary humans, it only produces a mild drowsiness. In earlier times, Deryni were exposed to it as part of their training; after the persecutions began, knowledge of it, like so much else, became fragmented and contradictory. It does appear quite frequently in The Deryni Chronicles and The Histories of King Kelson, and arrangements are made to expose Kelson and Dhugal to it in a controlled setting so they can learn to recognize it and mitigate its effects.
The climax of High Deryni involves the use of two such drugs, though they are not explicitly named. One is a very slow poison (said to take at least a day to kill) which also prevents Deryni from using their powers, and the other is an "antidote" which slows the initial symptoms of the first but hastens its end result
In John Dies at the End, the plot revolves around a mysterious drug called "Soy Sauce," which gives the user enhanced sensory perception, clairvoyance, and the ability to see monsters and dimensional portals.
The first book in the Space Cops series, "Mindblast", centered around the spread of Hyper 2, complete with full chemical name and a lengthy description of how the drug worked. Cue heartbreak when the heros discover that the man who created the drug wasn't some sleazy dealer, he had been trying to research a cure for his mentally retarded daughter.
The Black Company: Mushrooms growing on a golem's body have an euphoric effect. The consumers start singing or laughing for no reason, and stop feeling both tired and hungry.
Sleepy: This stuff could get addictive.
In The Minority Council, Pixie Dust is a super-addictive drug that enhances the magical talent of the user ten fold. It's also made out of the ashes of previous users, as prolonged use turns you into dust.
Mass EffectExpanded Universe introduced red sand, implied to be cocaine that's been exposed to element zero radiation. Gets the user high, and also lets them temporarily use a weakened form of biotic powers.
Milk of the poppy is basically opium, which is usually used to deal with pain, but can also get addictive. Gregor Clegane takes it to deal with his chronic headaches, and seems to guzzle it like water.
In "A Feast for Crows", this comes back to bite Clegane hard. His excessive use of the stuff has given him such a high tolerance for it that it's practically useless against the pain of a poisoned spear wound to his abdomen.
Sourleaf is a mild drug apparently similar to tobacco that, when chewed, stains the user's teeth bloody red.
Shade of the Evening is a psychotropic drug used by warlocks. It turns the user's lips blue.
Perdido Street Station probably had several, but the plot relevant one was Dreamshit. Which is made up of dreams made physical and sawdust. A dose knocks the user unconscious while they experience all the dreams (of all "genres") semi-simultaneously. It's very intense but the hangover doesn't last long.
Soma in Brave New World is the ideal recreational drug. There is a Real Life drug of the same name, but it's clearly not the same substance.
A Scanner Darkly had Substance-D, sometimes abbreviated as "D" or "Slow Death." It was a powerful hallucinogen with some schizophrenic side-effects.
The Red Dwarf novels had "Bliss", a brown powder that literally made you believe you were God, could supposedly get you hooked just by looking at it & would cause the user to become suicidally depressed for decades after coming down, which is probably what made it so addictive. Also, Better than Life, which was a sort of Lotus-Eater Machine in the books rather than the more innocuous artificial reality video game of the TV series.
The universe of The Ship Who Sang has several designer drugs, including Blissto and Seductron.
Fictional drugs abound in Naked Lunch by William Burroughs: Black Meat, Mugwump Juice, etc.
AUM from the Illuminatus! trilogy, alongside a whole pharmacy of real drugs.
The novel of Metropolis (and cut portions of the film) had Maohee, a hallucinogen that causes a large group to experience the visions of a single person (problems arise when a worker takes it). Drinking water erases any memory of the drug whatsoever.
In one of Andre Norton's books, she described a drug called crax seed, apparently chewed like tobacco (there's a reference to someone having spit out a crax cud). While high on the stuff, you're lots faster, stronger, and smarter than normal. When you come down, you come down hard: "What occurred to them later was not pretty at all."
Alan Dean Foster created Bloodhype, which must have fantastic marketing to ever sell, given that one dose is addictive — and withdrawal is fatal.
Discworld novels have the troll drug Slab, which is ammonium chloride cut with radium and is a hallucinogen - but only if you're a troll. It also makes their brains melt.
There's a long list of drugs in The Truth, some of which are genuine street names for real drugs, some of which sound like they might be street names for real drugs, and a couple of which are established as variants on Slab in Thud!. These variants include Scrape (called so because you scrape the remains of Slab you have and cook it with pigeon droppings and alcohol. Also, you're scraping the bottom of the barrel), and Slide, which seems to be an ersatz for crack and PCP.
The Lensman series had nitrolabe, thionite, bentlam, and hadive. However, opium and heroin were still in circulation.
Thionite is worthy of note. The user experiences the illusion of the gratification of their every desire, however noble or base. The catch is that while the psychotropic effects are tolerance-inducing (and so incredibly addictive that the one-time user can be traumatised for months), the physiological effects are not - and eventually the increasing dose required by the addict to have the same psychological effect is lethal. Always.
Subverted in House of Leaves, one of the writers/editors, Johnny Truant, of the story within a story claims in one of the footnotes/journal entries that he visited an old friend, who was a doctor, on one of his journeys. During his visit Johnny told the doctor about night terrors and screaming in his sleep, the doctor gave him a "yellow pill". Afterwords the dreams stopped and slept more peacefully. It was suddenly revealed that the Journal entries were faked by Johnny to make himself believe that his life was better than it actually was in the duration of the writing, painfully subverting the trope.
A full list of fictional drugs found in Dune would take up most of this page. The most important one is Spice, aka Melange. Melange is is highly desired not for recreational purposes, but because of its geriatric (life-extending) properties, and its ability to trigger precognizance and other advanced mental abilities in specially-trained individuals. Because of this, and the fact that it cannot be artificially synthesized, the entire economy of the Dune universe is centered around it. Word of God is that it's also an analogy for the importance of petrol/crude oil in the real world.
Tamora Pierce likes to do this. In the Tortall Universe, there's "laugh powder" and "hotblood wine" and "dragonsalt" and "rainbow dream." Some or all of these are probably real drugs under fantasy names (poppy is also mentioned), but we'll never know.
The "ThreeEye" in the first book, which was supposed to give its users second sight. Harry was skeptical until a junkie noticed a rather nasty psychic scar of his. Turns out it actually did work; it was a potion an Evil Sorcerer was mass-producing after he realized it was addictive.
Getting more specific in the Star Wars Expanded Universe, mind-altering drugs are typically called spice and many of them are actually mined. Confusingly, perfectly normal food additives are also called spice, and a lot of spices also have medical uses.
Easy justification for the confusion: "spice" is a street name.
Pure glitterstim is made by giant underground spiders, is activated by light, and grants temporary ability to read nonhostile minds, although it also brings paranoia and apparently can make people stupider - in the X-Wing Series, a habitual glitbiter forgets that he's talking to Wedge Antilles via hologram and thinks he's under attack.
Bota is a Magic Antidote to, well, everything, and when a Jedi accidentally injects herself with a recently-prepared sample she momentarily becomes one with the Force. She tries it again later and it works a second time, and it then preoccupies her thoughts and causes her to doubt and and struggle with herself until she overcomes it, gives the samples to a droid, and sends it off to give to the Jedi Masters, who presumably will know what to do with it. Years later Vader, having read the report, takes it along with something that would make the effects more permanent. It doesn't work too well. Apparently bota goes bad.
The Essential Guide to Alien Species mentions that Arcona can become addicted to salt. Yes, sodium chloride. It's a hallucinogen.
In Roger Zelazny and Robert Sheckley's Bring Me The Head Of Prince Charming trilogy, demons, angels, witches, and other supernatural beings drink a substance called ichor in lieu of alcohol. Ichor is also shown to have a raft of other possible uses, most notably as a magical preservative. It is also implied that a number of the more esoteric alchemical ingredients can double as drugs, particularly "black hellebore," which is noted to both stunt your growth and give your hairy palms.
The Sprawl Trilogy from William Gibson has several. There are a wide variety of "derms" that can be stuck to the skin and several kinds of crystals that are ingested or inhaled.
And in Neuromancer Case goes through several trying to find something that his augmented liver can't process.
Bordertown has a river (theMad River, aptly enough) of this stuff, which, oddly, produces edible fish which are a bit freaky but don't cause intoxication. There's also "dragon's milk", which is a drug for elves but just makes humans sick, and the drug in Finder which supposedly turns its users into elves... needless to say, it doesn't work.
Zilpha Keatley Snyder's Green-Sky Trilogy had Wissenberries. Also known as Sacred Berries, or just Berries. A narcotic with both medicinal and recreational uses, the Kindar also used it as a means of social self-control, even giving it to kids to quiet them down in class (Snyder was a school teacher, and the use of pharmaceuticals to make kids quiet and obedient is Older than You Think). Addicts were called "Berry-dreamers". Snyder never said that Berries caused the dreaded "wasting" disease, but she did say that people with the wasting tended to eat a lot of Berries, even when they won't eat anything else. If you were really hardcore you could try pavo-berries, which come from a "parasitic shrub" and will kill you sooner rather than later.
In the Warhammer 40,000 Ravenor series by Dan Abnett, where a large part of the plot involves a drugs ring investigation, mentions several fictional drugs such as lho (which is the 40k tobacco), obscura, lodestones and flects.
Continuing the previous example, several of these substances such as obscura and lho are also mentioned elsewhere in the Warhammer 40,000 canon, such as the Gaunt's Ghosts series. Though they are fantastic drugs, their uses approximate that of opium and something between cannibus and tobacco, respectively.
While Ravenor (mentioned above) depicts Lho akin to tobacco, descriptions of the effects of lho by other authors made it more similar to cannabis.
The Name of the Wind by Patrick Rothfuss has Denner Resin, which acts like opium. Addicts can be spotted because of their very white smiles (and the fact that they will do anything to get their next fix). This becomes a significant plot point when a local dragon finds a Denner Tree orchard, eats the trees, and becomes addicted. And then it runs out of trees...
In The Seagulls Have Landed by Colin Bateman, one of these, called "Crush" becomes a critical plot point. A whole gang war is going on over the stuff.
Fisstech in The Witcher series is, for all practical intents, cocaine.
In The Hunger Games we have morphling, a futuristic drug with probably heroin-like effects due to its name being derived from morphine, another opiate. Psychotic ex-Tribute Johanna has an addiction to it.
Labyrinths of Echo has a few, and established early on that people born in one world reacts abnormally on psychoactive substances of another. So while locals, along with children, guzzle their Soup of Rest for a little relaxation and daydreaming, while Sir Max was instantly on high to the giggling idiocy followed by a withdrawal "as if trying to Going Cold Turkey after several years of heroin addiction" despite the help of highly skilled healers. On the other hand, Kakhar's Balsam is a psychostimulant strong enough that locals don't let each other drive under it, even though their traffic is excruciatingly slow by our standards, while Max drinks it much like strong coffee, and suffers even less side-effects. Conversely, once he accidentally acquired pot from our world and gave it to his Nigh Invulnerable friend with steel self-control to "relax a little" — Hilarity Ensues; he was berated for not having a clue after personal experience with such things.
Lemon sap in Cherie Priest's Clockwork Century universe. It's distilled from a Deadly Gas and is highly addictive. The worst part, however, is that extended consumption turns the user into a rotting, flesh-eating zombie. A zombie.
Blisterweed in Jane Yolen's Pit Dragon Chronicles is normally dragon food. Humans occasionally smoke it, which causes aggression and (with prolonged use) distinctive stains.
Alice, Girl from the Future features a planet which is a slum, with no one caring about anything around them. Turns out a few years ago someone invented pills allowing time travel. Naturally, everyone spends as much time as possible reliving the best moments of his life. Future can be traveled to as well, but people are afraid to.
The Butterfly Kid gives us the "reality pill", a psychedelic which causes hallucinations that physically manifest. The alien invaders planned to use it to cause chaos. Unfortunately for them, our heroes are hippies who know how to handle their drugs....
Mentioned in passing in the Claire Carmichael book Incognito: kava is a drink which appears to be as popular as coffee or tea. Kava is a real drug, though not particularly well-known outside the islands of the Pacific.
In the Star Carrier series acetic acid has similar effects on the Agletsch as alcohol does on humans.
The Thraxas books feature two of note - thazis, which seems to be roughly equivalent to cannabis, and dwa, which seems to be the equivalent of heroin.
The Anno Dracula universe has "drac", which is made of powdered vampire blood and temporarily gives humans vampire abilities.
In M.C.A. Hogarth's Paradox series one of the few drugs the Alliance bans is "wet", so called because it liquifies the brain after two doses. And one of the cheaper ways of producing it is apparently to crack open sentient crystals.
In Coda, the Corp's music is this. You can even overdose on it if you're not careful.
In addition to the drugs mentioned under Literature, Red Dwarf the series also has Outrazone (prounced vaguely like "ultrazone" in a mock-Canadian accent), a chemical gunk that is apparently marijuana for mechanoids.
A second season episode mentions a powerful hallucinogenic mushroom species native to Titan (one of the moons of Saturn).
Apparently, by the time before Arnold Rimmer caused Red Dwarf's fatal accident, humanity had learned to create a form of gin out of marijuana. They called it Marijuana Gin.
In Smallville, red kryptonite is Clark's personal drug, having almost destroyed his life several times over.
Shows up in Battlestar Galactica, where Laura Roslin's use of the drug "chamalla" has elements of morphine, heroin and marijuana, including painful withdrawal, hallucinations, and its use as a painkiller rather than actually affecting the disease she's taking it for. Similarly, several of the pilots find themselves obligated to use "stims" (the all-purpose sci-fi version of amphetamine) to keep up with their round-the-clock responsibilities, and suffer severe physical and emotional damage as a result.
There was also a plant on New Caprica that was made into cigarettes that was smoked by Adama and Roslin, among others. From the way the effects were described, and that they already had an equivalent plant to Earth tobacco, it was assumed by many to be some form of cannabis. (They also referred to it as New Caprica weed!!)
"Stims" were used before Galactica, in Babylon 5, with similar realistic effect. The abusing character, Dr. Franklin (yes, a medical doctor), starts out simply using them as necessary to keep up with his work, then grows addicted, almost kills a patient, gets investigated by Security Chief Garibaldi (a recovering alcoholic who knows whereof he speaks), leaves his job, suffers withdrawal, and eventually almost dies in an attempt to "find himself." Garibaldi falls off the wagon once or twice, too, but only with conventional Earth alcohol...
There's also "Dust", a substance that temporarily grants telepathy to "mundanes" (non-Telepaths); this is used to take somebody else's thoughts for a spin. G'Kar gets his hands on some and tries using it on Londo; he realized halfway through that this was wrong, and got enlightenment (probably by the telepathic intervention of Kosh) in the process. He ends up writing a book, founding a religion, and becoming friends—if vitriolic ones—with Londo.
Season 5 has vampires feeding on drug-using humans-including Buffy's boyfriend Riley. It may or may not be the Orpheus from Angel.
Star Trek: The Next Generation, "The Game". A really lame video game with the power to seduce the entire crew's brains, to the point of unthinking loyalty to the game's creators, leaving the Creator's Pet and some-girl-we've-never-seen-before to save the day.
TNG also came up with synthehol, a justified version of this trope. It's a replacement for alcohol in beverages that can (apparently) be flushed from the system quite rapidly if you're called back to duty while in Ten Forward. The science book Life Signs: The Biology of Star Trek went so far as to figure a way how it could work: broken down by adrenaline when Red Alert sounds.
It's not just an addictive drug, it's their only means of nourishment past puberty.
In The Secret Circle, The concoction Nick and Faye were taking in Episode 2. Magic itself could also count.
"Medallion" introduces us to a magical "enhancer" called Devil's Spirit.
In True Blood (and the original books The Sookie Stackhouse Mysteries) vampires' blood, a.k.a. V-blood, V-juice, or V, is apparently more fun than every other recreational drug ever. It also increases the libido, the senses, and gives limited Super Strength. It even has medicinal value for those who are wounded. Too bad vampires as a whole don't take kindly to the commoditization of their life essence.
It also creates adverse withdrawal symptoms if one gets addicted. In True Blood, Jason's went static, and he became more aggressive and desperate. It also gave him a boner from hell when he overdosed on it, and had to have the blood painfully removed from his penis.
Don't forget that taking the stuff will create a mystical bond between the user and the vampire it came from, allowing them to feel each others emotions, making the user sexually attracted to the vampire in question, and at least to an extent allowing the vampire to keep track of the user, though the extent of how well this works is unclear.
Angel has Orpheus, a drug which vampires take by drinking the blood of a human who's injected it.
Lexx called its Fantastic Marijuana "gongslanger root".
Vraxoin in the Doctor Who story Nightmare of Eden.
One New Who episode dealing with a future Earth had drug-ified emotions. The invention of a "Bliss" drug led to the collapse of civilization, resulting in humanity being forced to live in horrible traffic for generations.
In SyFy's 2009 miniseries Alice, Wonderland's economy runs on the sale of liquid emotions extracted from Oysters, or people from the human world.
The Trolls of The 10th Kingdom have "dwarf moss" that makes you see fairies. However, the real example is the Troll King's invisibility shoes, which give their wearer such a great sense of power that they become more and more obsessed with wearing them all the time. Even touching them seems to be enough to begin the process; as soon as Virginia does so, she hides them in her backpack, thinks of nothing else, and acts increasingly paranoid, even clutching the shoes like Linus's security blanket. This is lampshaded by Wolf (twice!) when he claims "magic is very nice, but it's very easy to get addicted", and later tells Virginia she is "hopelessly addicted to those shoes... and I'm not too far behind!" Whether this is meant to be a parody or an object lesson is never made clear, but it certainly plays out with extreme hilarity.
A later example would be the scene in the Deadly Swamp, where Tony and Virginia eat the magic mushrooms, drink the swamp water, and sleep (after being explicitly told not to) and hallucinate a bizarre dream. The fact that Procol Harum's "Whiter Shade of Pale" plays throughout is of course only window dressing for setting the scene...
To hammer the point home, the soundtrack piece which accompanies both this scene and parts of the magic shoe shenanigans is entitled "Addicted to Magic".
Farscape has "Distillate of Laka" which helps take the edge off of John's Aeryn issues...when he doubles the dose.
The Dinosaurs had a drug special which Robbie, Earl, and Charlene became addicted to a plant that they never really named.
Robbie also develops an addiction to "thornoids" when trying to develop his muscle mass, a small annoying and insulting rodent covered in spikes that acts just like steroids when eaten.
The survivors of the show Whoops found a mutated berry bush that make you high by smashing it on your forehead.
Vampires' blood-drinking in Being Human is an addiction, not a biological necessity, and comes complete with painful withdrawal symptoms and a 12-step program (well, for a while anyway.)
Tracker had an Enixian who was making a drug that his species used as eyedrops into their highly sensitive eyes. It was destructive and often fatal to humans, which meant Cole and Mel had to put the producer out of business.
Dealing in kassa, an addictive corn-like grain, is a major source of income for the Lucian Alliance in the Stargate Verse. Some of the SGC's military actions in the last couple seasons of Stargate SG-1 involved kassa interdiction.
There's also the Blood of Sokar, a Goa'uld-developed hallucinogen used by Apophis to interrogate SG-1 in "The Devil You Know".
In Grimm Nick has to track down some junkie Wesen who get high some spices that are mundane and harmless to humans, but to Wesen its their version of heroin.
In Continuum Retrevinol (or "Flash" in street slang) is a drug from the future originally used as an Alzheimer's treatment. It allows the user to vividly recall memories, but results in a dangerous sleepwalking effect as they get lost in their memory, not to mention addiction as they continue to pine for their brighter past.
In The Flesh has a new drug just for zombies (or act and behave like people but without the need to drink or eat) and seems rather popular seeing as no other vices are available to them. The only person we see use one however ends up dead...well, more dead at any rate.
Brass Eye notoriously aired an episode on drugs which highlighted the danger of a new designer drug called "cake." This came in the form of a giant yellow pill, and potential effects included slowing down time so a second lasts an hour, a bloating condition known as "Czech neck" and, in one case, a girl who "cried all the water out of her body." What made this example particularly controversial was that several real-life celebrities were asked to give their opinions and one MP even asked a question about it in Parliament. Suffice it to say that he didn't see the funny side, and subsequent repeats of the episode include an apology.
Almost Human, being a future crime drama, inevitably has these. Such as "deep", a drug made from a deep-sea plant that is heavily addictive and has a low lethal dose.
The Piraka in BIONICLE bribe Brutaka (who's a good guy suffering from a major Crisis of Faith) into working for them by supplying him with Antidermis. This works as a sort of highly powerful steroid to his species... and is also the substance that (unknown to them) makes up the Makuta. As long as he only received small doses of the stuff (which were separated from Makuta's mind), he got a power boost, but when he soaked up multiple full Makuta essences, they took control over his body, seemingly permanently — but in return, made him infinitely more powerful.
Since the only law in the titular city of Mortasheen is "Chaos Reigns", then it should come as no surprise that a few of the game's Mons are made for producing these. Aside from the twoplant based ones, there's also the Crepusclent, which secretes psychotropic worms that give you ludicrously powerful Psychic Powers, but also causes very vivid hallucinations. There's also Jitter, who has tumorous drug-producing glands in its head, that make it "a viable alternative to the coffee machine". Unfortunately, due to these glands' they're pretty much all insane.
Over the Edge has several imaginary designer drugs such as Slo Mo, which gives the impression that time has slowed down.
Warhammer 40,000 features 'combat drugs' as options on several units, sometimes taken voluntarily. In-universe, these are basically a mix of stimulants, painkillers, and more exotic chemicals intended to keep a soldier going for as long as possible before dying. Usually in a berserk rage (the most common name for drugs inducing this condition being "frenzon"). The Ciaphas CainHero of the Imperium!!! novels mention the names of several drugs: 'slaught, psychon, blissout, and others.
Some background materials imply that the Emperor's Children, a legion of the settings worst abusers of combat drugs, manufacture those drugs from the basic components from broken down human bodies.
Combat drugs aside, there are several recreational drugs that exist in the background as well. The most ubiquitous being the narcotic lho-sticks, which are smoked like a cigarette and apparently an opiate. Others include obscura, gladstones, and grinweed. Another example that plays the trope much straighter is flects, which are warp-saturated bits of broken glass, "used" simply by looking into them; keep in mind that since they are tainted by the warp, flects are a much more insidious example than most others on this page...
The urban gang-warfare spinoff game Necromunda allows outlaw gangs to buy and use a variety of exotic drugs, including the frenzy-inducing 'slaught, "spook", which confers minor psychic powers at the price of probable mental and spiritual damage, and the powerful Icrotic Slime, which is really a brain-eating alien parasite that induces euphoria and considerable physical enhancements in its host to discourage removal (the user or an associate has to remove it before it encysts and begins feeding..).
Both Vampire: The Masqueradee and Vampire: The Requiem go for vampire blood as a drug. Humans who take it can look forward to halted aging and a measure of supernatural power, but risk getting addicted and being "blood bound," entering a state where no matter how much they hate the vampire, they can't raise a hand to harm them.
Additionally, the blood of other supernatural creatures has various effects on vampires in Vampire: The Masquerade: werewolf blood is analogous to PCP, for instance, while mage and fairy blood act as powerful hallucinogens.
The Mythologies sourcebook for Requiem actually introduces a drug specifically for vampires — Solace. It's injected via the tongue, made partly from the blood of teenaged "cutters", and allows the vampire to temporarily feel like they're alive again. It's extremely addictive.
A suggested plothook in Changeling: The Lost is the discovery of a goblin fruit known as "bloodroot", which has vampire-only narcotic properties, and the potential havoc that can ensue as unscrupulous changelings begin messing with vampire society and vampires, in turn, discover there is a drug they can actually feel and come hunting for it in turn.
The "Rites of Spring" sourcebook for Changeling: The Lost also notes that a shot of Glamour (the "mana" of changelings) has the same general effects as Solace — it makes a vampire feel alive again.
One running plot for the Orpheus line involved "pigment," a special type of heroin created by exposure to ghostly matter. Those who overdosed on it became their own special type of ghost - a "Hue," which could use Spite with reduced penalty.
The Book of Vile Darkness for Dungeons & Dragons lists several fantastic drugs along with game rules for them (presumably because it's a book about everything that is bad). One of the nastier examples is distilled pain, which, well. There are naturally rules for addiction, but fortunately you can always remove that if you have access to the right spell.
Also, in the Known World/Mystara setting for D&D, there's an Alphatian drug called zzonga.
Exalted not only has fantastic drugs, it has fantastic ways to produce mundane drugs. Namely, the Beasts of Resplendent Liquid, immortal dinosaur-like beasts engineered in the First Age by a Twilight Caste bioengineer. They feed on pharmaceutically helpful plants and ferment the plants into an associated medicine. The Guild, however, got their hands on the Beasts, and now mainly put them to work on poppy fields so they can corner the heroin market.
The future world of Shadowrun has come up with a lot of these. Perhaps the most interesting is "deep weed", an Awakened form of seaweed that causes you to astrally perceive when eaten... whether you want to or not. Then there's BTL (short for "Better Than Life") chips/programs, which come in varieties ranging from "pornography" to "emotional overload" to "deliberate synthesia".
Unknown Armies features the magical school of Narco-Alchemy, which allows an adept to apply the principles of alchemy to the drug trade. There's a lot of fantastic drugs involved.
Eclipse Phase features a lot of drugs. Recreational drugs, combat drugs, social drugs, narcoalgorithms for cybershelled characters... but most notably nanodrugs that use Nano Machines to induce states that simple chemicals could never accomplish. For instance "petals" are a variety of nanite-infused flowers whose petals send the user into a very trippy virtual reality when consumed, one popular variety makes the user think his hand has detached itself and is running away.
Sly 2: Band Of Thieves has Spice, harvested from Indian flowers. In large amounts, it causes uncontrollable rage and hatred in the user, acting a little like G-rated PCP.
The Fallout series features a wide array of drugs, from Mentats that boost your brainpower to Jet, a stimulant extracted from Brahmin manure with severe withdrawal symptoms. Also Buffout (short-term boost to physical strength and endurance) and Psycho (increased damage resistance). The player character can become addicted to any or all of them; certain traits taken at character creation can affect how effective and addictive they are.
Fallout 3 had to change the name of a drug morphine to 'Med-X' in order to keep distribution in certain countries. A cry against 'censorship' went out, but real life drug names were never part of the Fallout franchise before, and Bethesda pretty much designed them to act like magic potions anyway, and this one in particular doesn't realistically simulate morphine.
The plot of Max Payne revolves around Valkyr, colloquially known as "V", a PCP-like drug originally developed as a Super Serum for the military, but abandoned when it turned out to be addictive Psycho Serum, spurring the manufacturer to recoup their losses by selling the stuff to the mob, who then turned it loose on the streets. V also appears to have hallucinogenic properties, sending the titular hero on a really bad trip when he gets forcibly dosed up with it at one point.
On a related note, those painkillers he's popping regularly for most of the game must be something pretty spectacular.
Deus Ex has Zyme, the drug of choice for teenage rebels and junkies in 2052, in game it just gives you the effect of at least a dozen bottles of alcohol (wobbly and blurry vision) the Shifter game mod allows you to use it for temporary bullet time (normal effects still come after it).
The Nameless Mod has Melk (TM), it has religious uses with the Goat cult, who have fountains of the stuff that allow their high priest to resurrect herself everytime she is killed, until they are shut off
There is also crystal melk, which functions just like Zyme in the original game.
Deus Ex: Invisible War introduces Black Market Biomods, which have lements of this. They're illegal, and supposedly have negative effects on some people (forunately, your character is not one of those unlucky people). Complete with messages warning parents about the dangers. Plus, they're only sold by cyborgs in dark alleys.
The Elder Scrolls series has Moon Sugar and its derivative Skooma, not to mention loads of fictional alcoholic drinks. Puts a whole new twist on the Alchemy skill.
There are mods that allow you to produce Skooma out of raw Moon Sugar, which can then be sold for a decent profit to certain less than scrupulous traders.
It should be noted that most honest merchants won't even barter anything with you if you have Skooma on you. You have to drop it first.
Skyrim adds Sleeping Tree Sap, an extract of a glowing tree that make you feel healthy but is a hallucinogenic that slows you down.
Black Lotus is mentioned in passing several times in Baldur's Gate II - a backroom in the Cornet Inn suggest that it's an Opium Analog, and for a very mercantile city, Amn forbid the selling of it.
In Saints Row 2, the Sons of Samedi manufacture Loa Dust, which is popular amongst the potheads at college. Part of the Saints' campaign against the Sons is in figuring out how to make it themselves, then stealing the competition's market.
Liquid Sky in Snatcher, which was necessary since the game was made right in the middle of the 'War on Drugs' campaign.
And Narc from Policenauts, which gave a shout out to the use of Liquid Sky in Snatcher by complaining that the two places with the highest drug rates in the populated world are Beyond Coast and "America, where the War on Drugs is still being fought".
Narc is described as having 'the addictiveness of heroin and the hallucinogenic effects and potency of LSD'. Presumably it also gives you the high of heroin, because, otherwise, what'd be the point when you could take normal, non-addictive LSD?
One character in Policenauts has the ability to not even respond physically to being shot due to the anaesthetic effects of Narc, and the main ingredient is from poppies, so it's presumably more opiate than hallucinogen.
Nekoko's fairy dust in Yume Miru Kusuri.
Instead of the benign Mana potions found in other games,Dragon Age features lyrium, an addictive mineral that can either be inhaled as a powder or made into elixirs. Side effects include delusions, paranoia, dementia, obsessive behavior, hallucinations, dry mouth...higher doses or exposure to large amounts of naturally occurring lyrium can cause overdose-like symptoms along the lines of brain damage and death.
The pure lyrium idol in Dragon Age II is responsible for Bartrand and Meredith both going insane. The latter is a Templar, and thus already reliant on lyrium to power her anti-magic abilities.
Offhandedly mentioned is Aquae Lucidius, a liquor whose ingredients include wyvern poison. It's apparently popular among Orlesian nobility (including the Empress herself). According to Tallis, it'll make you see purple dragons for days. The codex entry has these testimonies:
"I feel confused but happy!" "It was as though my soul took wing and floated about my head." "I had a vision of my great-grandmother and found it oddly arousing." "I can see through time!"
Haze has Nectar, which makes soldiers easier to control by concealing how much of a Crapsack World they're in (and how much of that they're responsible for). Withdrawal is really bad.
Heavy Rain has triptocaine, a drug that one of the main characters, Norman Jayden, is addicted to. It's up to the player whether he will use it or not.
Norman is only addicted to triptocaine because he abuses it to suppress the symptoms of another addiction he has: ARI, his virtual reality sunglasses that can be very dangerous with overuse and really screw with your perception of reality. Near the end of the game, keeping them on too long will make his eyes bleed, and further use will kill him.
Hallex, seen in Samara's loyalty mission, causes euphoria and heightened senses. It's probably one of many drugs that originate on alien worlds.
The city of Billion in Gungrave is overrun with crime and a mysterious drug known only as "seed". It's highly addictive and gives the user increased resilience and strength, along with lowered inhibitions and euphoria. However, it eventually drives the user insane and leads to death. Turns out that seed is really derived from a malevolent race of alien parasites whose only reason to live is to reproduce by taking control of other lifeforms. And it's used in the technology that brought the protagonist back from death and nearly all the enemies he fights throughout the series.
When the Dream Tree is under attack by the ghostly monster Sludge, its leaves instead induce nightmares.
World of Warcraft has Bloodthistle, an herb that can only be taken by Blood Elves. When taken, it can increase spell power for ten minutes. On the other hand, it has a twenty minute 'withdrawal', which lowers your spirit. Oh, and it's outlawed in Shattrath City.
In a lore interview, the blood specialization of Death Knights apparently have blood that works like this, blood that heals their allies (blood tap and bloodworms being the most apparent) are addictive if overused, causing reliance and withdrawls in a way similair to the ghouls of Vampire: The Masquerade.
A fan-made sequel has 324-florazine iodase (street name "stardust"), which is a regulated but legal antidepressant for humans, and an illegal drug for several alien species.
The X-Universe has spaceweed (think space marijuana) and space fuel (a.k.a. Argon whiskey). Both are illegal in the Commonwealth, and both are highly prized by players for pacifying the Space Pirate population.
Ultima VII features Silver Serpent Venom, which temporarily ups all your stats only to permanently damage them when it wears off. Hilariously, using far too much of it at once will cause it to absurdly boost your character's stats when it wears off, making them ridiculously strong with some very odd effects on game mechanics.
The Gothic series has swampweed. While it works mostly like marijuana in that it is smoked in joints and affects perception, magic users can benefit from its side effects to enter a trance-like state required for certain magical endeavours. In particular, one of the storyline quests in Gothic 2 requires a priest of each of the three main gods of Myrtana to enter in this trance state with joints of swampweed to help the Eye of Innos regain its power.
Xenoblade has the red pollen orbs. Out of all the orbs that the Nopon manufacture there's the red variety. Like some real drugs, if they are processed correctly they can have some good potential uses, if not, they are very addictive and dangerous for health. There's a group of Nopon that sell this variety illegaly to the citizens of Alcamoth, and a huge sidequest arc involves finding who and where they are and putting a stop to their bussiness.
According to Yale in Episode 6 of Ambition, Paxwic is a new drug developed to subdue prisoners by making them blissed-out and non-violent. Angie was pursuing a study showing that Paxwic also has the effect of destroying the subject's critical thinking ability, which would make her enemies with the manufacturer Somaplex if her paper on the side effects were to be published. Later we learn that Ted was injected with an ominously-labeled faulty batch of Paxwic which could have heightened his anxiety just before he woke up to his blood-splattered apartment.
In the GURPS adventure based on the Chaos Timeline, one dealer tries to sell the PCs the drug "black niig", which supposedly makes people feel "like Stalin note Not our Josef Stalin, but still a bad guy, when he crushed his enemies' balls", and later they meet a crazy fundamentalist Christian who claims he knew a girl who never listened to advice, took nanodrugs and one day literally fell apart to dust.
The unnamed "cloudy drink" that is supplied to all the inhabitants of the eponymous Sex House when they refuse to have sex.
Prifleden in Avalons Reign is a completely legal drug injected through a needle (a "hypo") that fires off the pleasure center of the user's brain. Some people call it "orgasm in a needle", but others claim the high is much more intense than that. The company that produces it advertises the drug as non-addictive, but this does not appear to be true.
Spin, from the Bravestarr episode "The Price". It has a level of addictiveness bordering on Compressed Vice. Its effects are shown to be violent, with many users being taken to the hospital, and the kid who is the focus of the episode dying at the end.
Captain Planet and the Planeteers did this trope with an anti-drug episode, "Mind Pollution", where the drug in question (oh-so-creatively called "Bliss") turns its victims into strung-out hollow-eyed zombies. Like "Bravestarr" sample above, Linka's cousin, Boris dies. The episode even calls it a "new designer drug."
The G.I. JoeVery Special Episode "The Greatest Evil" featured a drug known as "Sparkle" which was sparkly red in color. The episode did go some way further than most of its type, however, in displaying relatively realistic effects of its use; one character was hospitalized with an overdose. At the end of the episode, the villainous drug-dealing Headman is unambiguously killed when he accidentally overdoses on his own drug, a rare moment for an episode of the type.
Of course, the message of said episode is a little lost when you consider that the main plot suggests that drug dealers were a greater threat than heavily armed international terrorists, for whom Even Evil Has Standards, leading to the Enemy Mine situation of teaming up with the good guys.
Actually, Fridge Brilliance saves the day here. If you wanted to take over the world, would you want the world to be a bunch of strung out junkies?
Yes, It'd be easier.
Actually in the episode the reason Cobra fights the Headman is because a Crimson Guardsman's sister gets hospitalized by Sparkle. The rest of Cobra is just in it to steal the Headman's money.
Which has the fortunate side-effect of merging two of Harry's biggest storylines, his drug addiction and his eventual becoming of the Green Goblin (which is alluded to in the series, as he is originally thought to be the Green Goblin before its revealed Norman's been manipulating Harry into taking the fall for him. Besides making the Harry story tighter it also makes the reveal of Norman Osborn being the Green Goblin a genuine shock for the first time in over forty years!)
Batman Beyond did a story about steroid use in athletics without using the word "steroids". They were "slappers" and turned out to contain the Venom used by Bane. The effects of Venom, of course, are much more disturbing than those of steroids.
Batman Beyond loved this trope. Splicers used animal mutagens to make a drug-like culture (no adverse or overt addictive side-effects were shown, but the Splicers were portrayed as being deviant and intrinsically more confrontational) and total-immersion Virtual Reality (basically computer-generated euphoric hallucinations) was portrayed as being very addictive, with catastrophic side effects inevitably resulting from prolonged use. Both episodes were very dark and laced with terrifying imagery, particularly the Splicer episode, which culminated with Batman defeating the bad guy by splicing him over and over again with different animals until the villain had a Superpower Meltdown.
Stimutacs, from the Sealab 2021 episode of the same name, are a fictional drug derived from the venom of the fugu invented by Sparks to make an assload of cash. Hilarity Ensues.
Marco: I have the strength of a bear that has the strength of two bears!
An episode of ABC's version of Doug had a tobacco analogue called Nic-Nacs, which could cause people's mouths to freeze up.
In an episode of Harvey Birdman, Attorney at Law, Birdman became addicted to a tanning cream that gives him massive boosts of energy because he's solar powered. It showed him selling all of his stuff to get more and end up getting a sort of intervention.
Bender from Futurama loves to smoke and drink, but that's okay since he's a robot. However, robots can become addicted to electricity, as Bender did in "Hell is Other Robots". It eventually caused him to be dragged to Robot Hell...
Similarly in "The Butterjunk Effect" Leela and Amy become addicted to a performance enchancer marketed as "Nectar", which comes from a species on Kif's planet. Near the end of the episode they have to kick the stuff and go through severe withdrawal doing so.
On Ovide and the Gang a.k.a. Ovide Video, there was a certain flower that, when sniffed, would make anybody extremely happy and relaxed. As in, very mellow, laid-back, and agreeable. The villain of the show hated the flowers, as he didn't like getting along with others, but many episodes ended with him being forced to take a sniff. So in a nutshell, all the good guys on the show would sniff a flower to get high, and the villain didn't want to but was usually coerced into doing it. On a kid's show.
Abe: Hm. I don't really feel anything... Well, I have a strong constitution, so I don't really I CAN TASTE THE SUN!!!
Transformers Prime: The synthetic Energon has this effect on Ratchet, making him increasingly unstable. This is a rare example of the drug being made by the affected party.
Bulkhead: Stronger, faster, studlier.
TRON: Uprising: In "Price of Power," the experimental weapon makes Beck faster and stronger, but also far more aggressive. The fact that this was allowed on a Disney XD show was probably because the situation was applied to computer programs as opposed to humans.
There have been a number of cases where jokes from comedy and Internet hoaxes have been taken seriously: cake, bananadine, and jenkem (supposedly a fadding drug among teens, created by storing raw sewage in a plastic bag for a week or so) have each raised their share of moral panic before people realized they were fake.
The latest of these would be strawberry Quik-flavored meth.
This one is at least based in reality. If allowed to dissolve in the mouth, some specific formulas of generic Adderall and/or Ritalin have a flavor very similar to strawberries.
On surveys about school environments, students will sometimes be asked how many times in the past thirty days they've taken Panda B; there is no such drug, and if someone says they've taken it, their survey answers can be disregarded because they're obviously lying.