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- Green Arrow. Snowbirds Don't Fly is a two episode arc in issues #85 and #86 that showed how Green Arrow's ward Roy "Speedy" Harper had become a heroin addict and the consequences of his actions.
- Iron Man: The Demon in a Bottle story arc from 1979 deals with Tony Stark's slow descent into alcoholism. Although he managed to seemingly beat the addiction by the end of the arc, it returned later to further ruin his life, and has been a major defining element for the character ever since.
- The Kamen Rider Gaim fanfics I shouldn't be alive, Unless it was for a reason and Gone Cold Turkey portrays Mitsuzane's slow descent into heavy drinking, albeit underage. The factor of Micchy drinking himself to death with (as much guilt) is he can cope with the deaths of Kouta and Mai, to the point that his health deteriorates even further. It gets even Up to Eleven with the latter fic where Micchy's binge drinking began affecting his health. In the end of both fics, he begins recovering with Takatora's help.
- Vigilante Tendency: After meeting his heir, Tsuna, and seeing the...quirks of him and his friends/future Guardians, Timoteo (Vongola Nono) starts adding whiskey to his tea and begins a steady descent into alcoholism. His Cloud Guardian Visconti quickly joins him once he meets his student/successor Kyouya Hibari.
- The primary plotline in the Wakefield story in Traffic centres on Bob Wakefield's daughter Caroline, who develops an addiction to heroin after being introduced to it by her boyfriend. Her parents put her in rehab, but she escapes and resorts to theft and prostitution to fund her habit. At the end of the film she's back in rehab and seems more committed to recovering.
- Several minor characters in Trainspotting and its source novel undergo this, most notably Tommy (as per the page image), who is introduced to heroin by Renton after his girlfriend dumps him, and ultimately contracts HIV.
- Requiem for a Dream chronicles three out of four main characters' agonizing descent into drug addiction. Director Darren Aronofsky stated that he was attempting to explore the parallels between different types of addiction in the film:
Requiem for a Dream is not about heroin or about drugs... The Harry-Tyrone-Marion story is a very traditional heroin story. But putting it side by side with the Sara story, we suddenly say, 'Oh, my God, what is a drug?' The idea that the same inner monologue goes through a person's head when they're trying to quit drugs, as with cigarettes, as when they're trying to not eat food so they can lose 20 pounds, was really fascinating to me. I thought it was an idea that we hadn't seen on film and I wanted to bring it up on the screen.''
- During the course of Scarface, Tony and his girlfriend Elvira become addicted to cocaine as he rises up the ranks of the dealers/distributors. "Getting high on your own supply" is a big no-no among drug dealers, and is one of several factors that ultimately end up dooming Tony.
- The Basketball Diaries (and its source book) depicts Jim Carroll's descent into heroin and cocaine addiction.
- In Days of Wine and Roses, Kirsten goes from staunch teetotaler to complete alcoholic and is unwilling or unable to attempt recovery, which costs her her husband and child. Joe seems to have some issues from the start of the movie, but does manage to dry out.
- The film adaptation of The Lord of the Rings treats us to a chilling flashback of how a hobbit-like character named Sméagol succumbed to the One Ring's Addictive Magic and slowly degenerated into the nocturnal creeper we all know and love as Gollum.
- Amy tells the tragic Real Life story of Amy Winehouse, whose descent into alcoholism and drug addiction eventually leads to her death at the age of 27.
- Chronicle is about the slow descent of a supervillain into homicidal insanity. The catch is, it's not the powers that are addictive, but his own abnormal addiction (to cameras) that gets worse as the domestic abuse piles up. As seen in both him and his abusive father, they outright ignore the possibility of a solution to their regular problems because it involves withdrawal from addictions that they both deny, and their decisions are catastrophically idiotic as a result.
- Skid in Swing High, Swing Low; once a promising trumpet player, to a bum on the street looking for his next drink.
- Dick Diver in Tender Is the Night begins to drink heavily as a coping mechanism due to his wife's mental illness, eventually becoming The Alcoholic.
- In Venus Prime 4, Sparta starts taking various pharmaceuticals in an attempt to counteract the drugs that erased part of her memories. Instead, she ends up severely addicted to one of the drugs, and by the end of the book, she's caused so much damage to her own brain from drug abuse that she loses her enhanced perception abilities.
- A Scanner Darkly - like the movie adapted from it - depicts undercover cop Bob Arctor growing addicted to the scary fictional drug Substance D as part of his cover.
- This is what Valley of the Dolls is about, with prescription medicines. Neely O'Hara is the one who especially fits the profile. As a fresh-faced kid she hits the big time, her film studio makes her take Dexamyl to lose weight, they keep her awake so she takes Seconals, then Nembutals, and on and on. She is a true addict, building up a tolerance so that she has to take more pills to get the same result. She's put in a mental hospital to recover, but by the book's end is back on pills, plus Demerol and booze. Jennifer, a stress insomniac, is dependent on Seconals for sleep and Anne is becoming psychologically dependent on them by the end.
Live Action TV
- Babylon 5:
- In the second season Dr. Franklin starts using stims to keep himself going as more and more injured refugees arrive from the Narn-Centauri War. As time goes on, he becomes more reliant on them, even after the war ends and by the mid-third season it's clear he's become dependent on them. Once he realizes it, he goes on a "Walkabout" to figure things out.
- Michael Garibaldi is shown to have had a problem with alcohol in the past, but aside from one relapse in the first season he doesn't touch the stuff, making a point to just drink water, until the fifth season at which point he starts spending more and more time intoxicated to passed out which causes him to miss a critical call, and possibly a chance to stop a war before it begins.
- A Very Special Episode of Saved by the Bell (which has since become infamous for its copious Narm) was focused on Jessie becoming addicted to caffeine pills.
- In The Mentalist Cho gets injured on duty, and his doctor gives him pain medication which he takes as needed. Over the course of several episodes we see him popping pills. Eventually he realizes he's becoming addicted to them, so he flushes the remainder of the pills down his toilet and never takes them again.
- An early story arc in Breaking Bad featured Jesse (already a habitual user of crystal meth and weed) being introduced to heroin by his girlfriend Jane and slowly becoming addicted. After Jane overdoses, Walt sends Jesse to a rehab facility and he remains clean for most of the rest of the series.
- During the fifth season (Frank's last), Margaret's engagement and eventual marriage to Donald Penobscott effective ends her affair with Frank, which drives him over the edge, and as that season progresses, his obsession for her grows and grows to pathological proportions; his attempts to just talk or eat with her usually ends with him breaking down and making a move on her, only for her to push him away and threatening to tell Penobscott.
- In "Dr. Winchester and Mr. Hyde" Major Charles Emerson Winchester starts taking amphetamines to make up for a lack of sleep and quickly becomes addicted to them.
- In the third season, Agent Mike Warren develops a dependency and then full-blown addiction to the pain medication he is prescribed following his attempted murder last season. Eventually, Mike decides to detox and appears to beat his addiction with the help of his roommates..
- The Young Lawyers had an episode, "The Whimper of Whipped Dogs", showing an old girlfriend of Aaron's who has become an incredibly degraded heroin addict. We repeatedly see the contrast between his memories of her as healthy and beautiful and her current deteriorated state. Written by Harlan Ellison, the original script was massacred in rewrites by ABC's requirement that the drug angle be downplayed. You can see his original work in his book The Other Glass Teat.
- Good Girls Revolt has Cindy who is drinking more, and more often, as the show goes on, at first only when she's stressed, but by the end of the first season she's taking swigs from bottles at other people's places.
- In The Crown (2016), Prime Minister Anthony Eden becomes addicted to the painkillers and amphetamines he was prescribed after a botched surgery left him in constant pain. (The influence of these drugs is now considered to be responsible for his poor handling of the Suez crisis.)
- "Slow Down" by Brand Nubian is a What the Hell, Hero? directed at the speaker's ex-girlfriend. She started off clean (which isn't to say she didn't have other problems), then became addicted to gateway drugs either before or during her relationship with him, and finally to crack cocaine. He broke up with her because the addiction had changed her personality and done a number on the way she looked, and she was doing things like stealing money from him and selling her body to pay for her habit. It seems that part of him was hoping that the breakup would be the kick in the pants she needed to get clean, but he can see that she hasn't changed.
- The New Pornographers' 2000 debut album Mass Romantic features "The Slow Descent Into Alcoholism," which is Exactly What It Says on the Tin: the singer is slowly descending into alcoholism, spending all his money on booze and refusing to get help.
I say, my, my slow descentInto alcoholism it wentTo my head, where I really need itWith the views that remain untreatedI say, my, my slow descentInto alcoholism it went...Something like this songSomething like this songSalvation holdout central...
- Eight Cicadas starts with a flash-forward to Annette as an alcoholic, though her story proper starts with her as a young social drinker. Shark, her nephew, also descends from sobriety to violence and alcoholism before his death.
- An infamous example occurs in the Brave Starr episode "The Price", in which a teenage boy named Jay becomes hooked on "spin" and gets progressively more focused on getting more.
- The Simpsons: In "$pringfield", Mr. Burns opens a casino in Springfield and Marge becomes a gambling addict. She acknowledges her problem at the end of the episode.