"We are as close as an elderly gay man and a straight teenage boy can be."
A friendship which develops between two characters that would seem unlikely to be friends, whether it's because of them having diametrically opposed personalities, holding beliefs that would normally get one to try to demonize the other, or some other quirks of their beings that would lead to them clashing. Through their friendship, they learn more about each other and about themselves.
The characters in an Odd Friendship may have little to do with each other initially — or even begin as bitter enemies — and their friendship grows over time.
Distinguished from an Odd Couple
in that these are usually two characters in an ensemble show, or a regular character and a Recurrer
; whereas an Odd Couple
usually consists of the two main characters in a show.
See also: Interspecies Friendship
, Intergenerational Friendship
, Action Duo
, Vitriolic Best Buds
Compare Friendly Enemy
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Anime & Manga
- May and Scar from Fullmetal Alchemist. A cute little princess with an adorable pet panda and a Serial Killer out on a Roaring Rampage of Revenge. They get along surprisingly well.
- In Tower of God, Anak, who plots to kill the entire family of Zahard, and, well, Androssi Zahard.
- Toji Suzuhara (sports jock) and Kensuke Aida (Military Otaku) in Neon Genesis Evangelion
- Ichigo and Minto of Tokyo Mew Mew. And Ichigo and Zakuro, and Ichigo and Ryou.
- Ahiru (or Duck) and Fakir in Princess Tutu.
- Genki Girl Yuzuriha Nekoi and Gentle Giant Kusanagi Shiyu, in X/1999 with a twist: she is a Dragon of Heaven, he is a Dragon of Earth, two people from forces fighting against each other. [[spoiler: Also, it later changes to an Odd Couple of sorts after Yuzuriha confesses love to Kusanagi, and he apparently returns the affections, though he maintains a chaste relationship with her since she's 14 at the time. (Not unlike a superpowered couple from the other famous "X-series"...) Kusanagi seems to be the only one aware that she is supposed to be the enemy, though.
- Asuna and Ayaka's friendship from Mahou Sensei Negima! mostly consists of beating each other up and insulting one another. They really are friends though, read any of their arguments as if they were friends and it makes way more sense than if read as if they really did hate each other. Such as this one. (Read ahead about four pages also.)
- In Naruto, Hidan and Kakuzu certainly have a very odd friendship. Despite bickering like crazy, they still look out for each other's wellbeing and seem to be genuinely concerned for each other. Even though they initially don't seem to get along at all, it can be seen that when the time comes and they get serious, they work together quite nicely.
- It gets weirder than that. The reason they're partners is because Kakuzu has very little patience and killed his past partners. However, Hidan is immortal, and Kakuzu can patch him up if needed. Also Kakuzu attacks very indiscriminately, but with Hidan's immortality that's not a problem and allows unexpected strategies.
- Considering their personalities (Kakuzu only cares for money and the sure-fire peace of mind it gives him, Hidan for his bloodletting deity to whom he sacrifices people), it's hard to say whether they're actually friends or not. Making it even stranger.
- Akatsuki is pretty full of this trope, essentially seen in every functioning partnership - besides Pain and Konan, pretty much all the other members share an Odd Friendship. Thoughtful, stoic Itachi & boisterous, violent Kisame might be the best example as they're different as day and night, yet genuinely respect and like each other in spite of it. Similarly, Sasori worked rather well with Orochimaru (until the latter betrayed the group and earned his partner's loathing), and despite his philosophy being the polar opposite to Deidara, the two also had a mutual respect outside it (helps that Deidara strives to not disrespect people on principle just because they mightn't agree with him. Finally, while they aren't actually partners, Tobi has one with Zetsu, which probably stems from their history together (which goes back to before even the Kyuubi attack).
- Naruto and Shikamaru. They would seem to have nothing in common with one being Hot-Blooded and the other the poster boy for Brilliant, but Lazy, but they have an extremely strong friendship that is one of Naruto's few normal ones.
- Bonus points for the fact that even in their Academy days, although Naruto didn't consider him one of his True Companions back then, Shikamaru was one of the few people in their age group (the others being Kiba and Choji) who Naruto seemed to get on well enough with to actually spend time in his company. Not quite friendship then (more like friendly acquaintance), but it forms further basis for one when the story begins proper and they (along with the rest of the Konoha 12) become Fire-Forged Friends
- Short-lived though it was, the relationship between Naruto and Sasuke was one of the oddest friendships in the series. At the time, Sasuke was a quiet, moody prodigy who was ridiculously popular despite wanting to be left alone. Naruto was a loud, obnoxious idiot who was shunned despite wanting friends more than anything else. Just to add to the weirdness, Naruto was in love with the girl in love with Sasuke, and both of them desperately wanted to fight each other. Not to mention that they started out hating each other, their first real interaction as classmates being a fight. Despite all this, for a brief time in the series they had a very strong friendship marked by mutual respect, affection, and trust. This bond was, in fact, so strong that Naruto insists that Sasuke is still his best friend despite Sasuke trying to kill him on three separate occasions.
- There was a brief and unspoken moment of understanding back in their Academy days: Few days after Sasuke lost his clan, Naruto found him near a pond and Naruto wanted to talk to him. Both looked at one another and really didn't say anything. Naruto has mentioned that had he viewed Sasuke first as a potential friend rather than rival, that things might be different.
- The Tailed Beasts and their Jinchūriki hosts. Especially odd considering that for centuries, the Tailed Beasts were thought of as nothing more than living, malevolent weapons made of chakra that needed to be controlled, instead of the sapient beings that they are. This made the Beasts very distrustful of humans, but several of them began to warm up to each of their recent Jinchūriki hosts, usually because they treat their Beasts with respect. The first friendship like this seen in the series was between Killer B and Gyūki the Eight Tails, were the latter serves as the Straight Man as opposed to the former's goofiness. It's oddly heartwarming in a way, so much so that after seeing how those 2 get along, Naruto expressed his desire to be friends with Kurama the Nine Tails. This friendship finally came to pass starting with Chapter 570.
- Admirals Lindy and Leti from Magical Girl Lyrical Nanoha. The former is laid-back and very approachable while her best friend oozes professionalism from every pore.
- The roles reverse when there's alcohol involved; Leti downs wine by the bottle while Lindy desperately tries to keep her under control.
- Virtually any combination of any two Yes! Precure 5 characters who were not already friends at the end of the first episode. The one that seems to have surprised the fandom the most is Komachi and Urara, although Rin and Karen are most in the spirit of the trope.
- Gil and Alice from Pandora Hearts are like this. Connected through their care of their fellow pal Oz They grow an odd bond though neither of them are likely to admit it,so they settle for giving each other endearing insults such as "Seaweed-head" and "Baka-Rabbit". They begin to trust and like each other more throughout the series.
- Kyon and Haruhi from The Melancholy of Haruhi Suzumiya. Kyon is laid-back and doesn't believe in anything strange or supernatural and Haruhi is an over-the-top, borderline sociopath who starts her own club (ironically at Kyon's suggestion) devoted to the strange and supernatural. Despite this, they've become best friends who can trust each other with almost anything.
- Kyon and Itsuki as well. And in the 7th book of the novel series, Yuki and Mikuru develop one.
- Kyon and Itsuki are a really strange case. On the surface they seem to be buddies, as they are often seen hanging out and playing board games in the club room. However, Itsuki irritates Kyon to no end due to his tendency to go into long-winded metaphysical/psychological spiels, his playful teasing, Poker face, and his willingness to go along with Haruhi's outrageous schemes. That being said, they are what you would call "friends" as Kyon is the only member of the club whom Itsuki can share his theories with, and Kyon reluctantly comes to admit that he trusts Itsuki.
- Plucky Comic Relief Helen and uber stoic Deneve in Claymore.
- Lithuania and Poland from Axis Powers Hetalia. Lithuania is gentle and serious-minded, whereas Poland is bossy and frivolous, but the two are Heterosexual Life-Partners at the very least. America and Japan have also entered one in the modern day comics; America is talkative, energetic and somewhat ditzy, Japan quiet, emotionally reserved and relatively level-headed, but that doesn't stop them from bonding over video games or celebrating holidays together.
- In the anime dub, France acknowledges that the friendship between Germany and Italy "makes absolutely no sense."
- Gohan and Piccolo from Dragon Ball Z (Piccolo originally kidnaps the young Gohan for some Training from Hell and forces him to fight against the invading Saiyans).
- Also we have Hercule and Majin Buu while Hercule first only got close to Buu to try kill him he eventually formed a genuine friendship with the pink demon the friendship was enough to convince Buu to make a Heel-Face Turn.
- Kuwabara and Hiei from YuYu Hakusho, who are usually hostile toward each other, but have each other's back when it counts the most, particularly at the climax of the Chapter Black saga.
- Book Dumb Gentle Giant Kurita and Trigger Happy Sociopathic Hero Hiruma from Eyeshield 21. Kurita is huge, friendly, gifted with physical strength (although he does work very hard) and enjoys football because it's football and he likes playing with his friends. Hiruma is skinny, barely average in a lot of athletic areas, ruthless, terrifying and only interested in winning. They're best friends.
- Harima and Yakumo in School Rumble.
- Shizuo Heiwajima (who personifies the Naritaverse tendency towards Crazy Awesome and Dysfunction Junction like no other) and Tom Tanaka (Nice Guy and Only Sane Man) from Durarara!!. His Intergenerational Friendship with the Yakuza princess Akane Awakusu also counts.
- Conrad and Yozak of Kyo Kara Maoh weren't actually an odd friendship when they became friends. Both halfbreeds about the same age, Conrad's father rescued Yozak, only survivors of their regiment in which Yozak was Conrad's trusted lieutenant, it's all good. But when the audience finds out they're best friends it seems extremely odd. Court-raised perfect guy with absolute discipline and fanatical loyalty and the cross-dressing Kansai-drawling muscle-bound spy with no respect for authority?
- Not to mention Conrad threatened to kill Yozak in the second episode they appeared in together, if he messed with the king. That scene is so much weirder and you totally feel for Yozak (and his attitude toward Yuuri, the new center of Conrad's life) when you watch it knowing they've been close friends for at least fifty years, and the only real friend either has that's still alive.
- Their two major fights are also frighteningly serious, one because of a cursed mountain that turns people against each other and the other during Conrad's apparent Face-Heel Turn on a Mission from God. Interestingly, what Yozak's protecting in the second one he only resolved to protect in the first place partly for Conrad's sake.
- Joe and Gomamon from Digimon Adventure certainly fit this. Of all the human-digimon pairs, they're the two who have the most incompatible personalities, yet they get on surprisingly well.
- Unanimated Lucky Star discussed why Hiyori, "an otaku in every sense of the word", would be friends with "honour students" Minami and Yutaka.
- Isshin Kurosaki and Ryuuken Ishida have been cordially vitriolic friends and colleagues (as fellow doctors and Retired Badasses) for at least 20 years, despite the fact that they have dissimilar personalities (waaaay overeager vs. infuriatingly aloof), diverging career tracks (GP vs. hospital executive), and are situated on opposite sides of a spiritual war between the Shinigami and the Quincies. Their shared Mysterious Past only begins to be explained in the final arc.
- Subverted with the Generation Xerox, Ichigo Kurosaki and Uryuu Ishida. Their initial rivalry turned into a Fire-Forged Friendship very quickly. While they try to project the kind of vitriolic bickering their fathers engage in, the other characters Lampshade the respect this conceals. Neither Ichigo nor Uryuu appreciates having this pointed out.
- In Saki, this describes the friendship between Yumi Kajiki and Satomi Kanbara of Tsuruga. The former is an exceptionally serious, stoic and analytical individual, albeit one whose stoic facade doesn't hold up all the time (particularly regarding her soft spot for Momo). The latter is cheerful, laid-back and easy-going, but more intelligent than she seems at first glance. The two became friends after realizing each other's Hidden Depths.
- Despite the diversity of the main crew in One Piece, they often aren't seen interacting with each other in a more personal way, one of the stranger ones we see is the friendship between Naïve Newcomer Chopper and the hard-edged Adventurer Archaeologist Nico Robin. Mutual love of learning aside, their difference in temperaments make it strange.
- In Polish comic Tytus Romek I Atomek two of the main characters Romek & A'Tomek. The first is a tall, handsome jerkass and a SmugSnake, while the other is short, fat and nerdy. In every other reality Romek would be the bully who picks on A'tomek. Here not only they are very good friends but Romek has plenty of respect for A'Tomek's superior intellect and considers him the authority figure.
- Of course, there's the iconic friendship of Batman and Superman. One would not expect the big blue boy scout who works with the law to consider the terrifying vigilante with issues his best friend, but there it is. Heck, Supes is even solar-powered, while most incarnations of the Bat have him refusing to operate in the daytime. Their methods, attitudes, and philosophies differ hugely. But that won't stop them from teaming up to curbstomp anyone stupid enough to come to Earth looking for a fight.
- Their friendship was not portrayed as particularly unlikely and rocky during the Golden Age, Silver Age, and for much of the Bronze Age. It wasn't until the Crisis on Infinite Earths Continuity Reboot that suddenly the idea of them being friends was considered odd.
- And yet it also makes sense- both are alienated from humanity in a way. Superman due to his powers and alien heritage, and Batman because... well, he's Batman. Theirs is a friendship founded on mutual respect, trust, and admiration, even if they don't always see eye-to-eye. In what may well be a moment of heartwarming, both of them hope and assume that, should they die, the other one will be there.
- Both of them are hardline adherents to the "no-kill rule", and they both lost their (biological) parents at a young age. And despite the fact they have very different respective outlooks on life, they both have a strong sense of right and wrong.
- And while this leans a little into pragmatism, some stories have established that Batman carries around Kryptonite on his person at all times just in case Superman goes rogue, and that Clark is fully aware of this and trusts Bruce to subdue him if necessary.
- Cable, a messiah wannabe/Time Travel/Shell-Shocked Senior, and Deadpool, a Bunny Ears Assassin/ Deadpan Snarker/ enemy of the fourth wall.
- Deadpool and any of his friends, really.
- From Lenore the Cute Little Dead Girl, we have one of the most extreme cases of Intergenerational Friendship: Lenore, an imaginative, Chaotic Stupid, 10 years old, dead girl and Ragamuffin, a deadpan, level-headed, magnificent vampire, trapped in a cotton doll.
- Wolverine and everybody, Nightcrawler being a particularly prominent example. In the Claremont run where both characters first appeared, they were together almost all the time.
- Archie Comics: Betty Cooper and Veronica Lodge. Their friendship goes against the very logic that governs every aspect of the universe, and yet...
- Victor Von Piro and Frank Einstein Jr. from Minimonsters. They're exactly Polar Opposites, and they always argue and criticize the other's behaviors; but they can't live without each other. In brief, a male and monster version of Betty and Veronica, but without the Love Triangle.
- In Watchmen, Rorschach is a broke, insane, psychopathic vigilante, the only one operating after the Keene Act has passed. His best friend Dan Dreiberg, the Nite Owl II, retired after the Keene Act and kind of half became the mask to Rich Idiot with No Day Job. He's friendly to the point of being a doormat (look at when he invites Laurie to stay with him and she keeps talking over him.) Even in appearance they are opposites, Dan being tall, plump, brown-haired, and when he takes his glasses off, handsome, whereas Rorschach is incredibly short, skinny, red-haired, and is "fascinatingly ugly".
- The short lived (2 issue) team-up of Spider-Man and Loki went a lot like this. Loki wants to save one of his mortal offspring from the Chaos Sorceress possessing her. Spider-Man wants to save the world from that sorceress (and get her to stop hitting on him). They work together. Awesomeness ensues. On Loki's end, complaining that Spider-Man isn't giving him enough respect as a god and wondering why mortals are all so weird. On Spider-Man's, wondering what working with a mostly-evil guy like Loki means and buying chili dogs to share with Loki.
- Plus, at the end, Loki decided he owed Spidey one, and gave him a sort of talisman that he can cash in for that favor. Even though the arc is never brought up (again, it was only 2 issues) fans are hoping it could be a possible Chekhov's Gun to undo One More Day or something. Only time will tell.
- has done it. Albeit in a crossover with BTVS.
- Also, snarky god meets snarkier webslinger. Who doesn't want to read that?
- Prior to the accident that forced them together forever, Reed Richards and Ben Grimm, near perfect personifications of the Hollywood Nerd and (seemingly) Dumb Jock, yet were the absolute best friends ever. Reed never missed one of Ben's football games, and Ben gave Reed the championship winning game ball, despite Reed not knowing the significance. Reed kept the ball forever.
- Depending on the Writer, The Penguin and The Joker have this type of relationship, as well The Penguin and The Mad Hatter or Penguin and the Riddler.
- In Death Of The Family, in a twisted way, this is how Joker sees his relationship with the other Bat-Villains, like Penguin and Riddler and Batman.
- Plastic Man and Batman are somehow rather close friends despite Batman's usual distrust towards reformed criminals and usual lack of humor and Plastic Man's status as The Atoner (though at first he was Only in It for the Money) and goofy personality.
- In Sex Criminals, in middle-school Suzie was a 'good girl' and Rachel was a 'dirty girl', with Rachel even disparingly calling Suzie "slut" on at least one occasion. Sixteen years later, they're roommates.
- In Raymond Briggs' The Man, a young boy forms an unusual friendship with a tiny (and bossy and demanding) man.
- Guardians of the Galaxy: Peter Quill is a former intergalactic super-hero / swashbuckling adventurer-turned-Broken Ace, while Rocket Racoon is... well, he's a racoon. Also applies to Peter Quill and Jack Flag, who's a street-level superhero from Arizona who "doesn't do cosmic stuff" meaning he's about as different from Quill as it's possible to get. Also also applies with Rocket Racoon and Groot, who is a walking tree from Planet X, where he claims to be a king.
- In Transformers Meta, Grimlock and Bumblebee are this; despite being polar opposites in every sense of the word, the two are incredibly close friends.
- Empath Smurf and Polaris Psyche in Empath: The Luckiest Smurf. The only things they have in common with each other is that they're both telepaths and they have both lived in Psychelia. Otherwise, Empath comes from a race that the Psyches see as "savage".
- Empath and Grouchy, with Empath being emotionless in his early years and Grouchy just being a grouch.
- And there's Grouchy with the more personable and talkative Tapper, as well as Grouchy and Duncan McSmurf.
- The friendship between Navarone and Celestia in Diaries of a Madman is very strange. Not just due to the differences in social standing (an average Deadpan Snarker human and pony princess respectively), but due to the way their goals end up conflicting and his tendency to end up as her pawn, even the definition of friendship you'd use for all this would be unusual.
- Captain August Gallardi forms one with Eldar Farseer Maeteris in the Mass Effect/Warhammer 40,000 fic The Mission Stays The Same. Normally, they should hate each other, but they are the closest thing to normality they have once they arrive in the Mass Effect universe.
- The author's notes for chapter 9 of Bait and Switch (STO) actually said this of supporting characters Admiral Amnell Kree and her flag captain Bronok Zell. The former is a hard-bitten, no-nonsense Dominion War veteran, whereas the latter is a Cardassian immigrant who takes very little completely seriously. The funny thing is, she requested him.
- TD and Celestia's friendship (and eventual romance) in TD the Alicorn Princess. This being after Celestia accidentally traps him in Equestria, and after numerous instances of the two punching the other in the face.
- Mirrors Image: Luna and Amethyst, the last Queen of the Changelings were sort of friends, even though Amethyst threatened to turn Luna into a Changeling constantly (which given Luna's then lousy mood probably wouldn't have worked). When Amethyst confronts Celestia on a separate matter in a flashback, she takes a moment to call Celestia out on her mis-treatment of her sister.
- Pride and Prejudice: dour, brooding Darcy and light-hearted Bingley, particularly in the Keira Knightley movie — whenever they're together, Darcy seems itching to punch Bingley in the face. The vibe in the novel, on the other hand...
- In this case the Ho Yay is all fanon. In the BBC TV adaptation they are clearly Heterosexual Life-Partners, and their relationship in the novel can easily be interpreted that way too.
- From Hell's Children: there's Precision, an evil alien bent on killing all humans who’s best friend just happens to be a little human girl.
- In Peter S. Beagle's "Professor Gottesman and the Indian Rhinoceros", a professor is friends with what he insists is a talking Indian Rhinoceros. It says it's a unicorn. Despite this difference of opinion and other differences, it's a quite close friendship.
- Spenser and Hawk from Robert B Parker's stories. Spenser is a moral, honour-bound PI and Hawk is a semi-sociopath who makes his living as an enforcer and has no qualms at all about killing. Which is not to say they have nothing in common. Both are Sophisticated as Hell (though Hawk likes to pretend he's a dumb thug), and prefer to play by their own rules. Both clearly have the deepest respect the other.
- The Lord of the Rings: Merry and the entire royal house of Rohan. Especially his close friendship with Éowyn.
- Also Gimli and Legolas.
- Especially odd given that, up to that point, Dwarves and Elves weren't on the best of terms and their parents didn't get along in The Hobbit.
- This is the entire plot of The Actor And The Housewife, pairing a Colin-Firth-esque British movie star and a Mormon housewife/mother of four/part-time screenwriter. People think their best friendship is entirely strange.
- Clear and Present Danger: Representatives Alan Trent (a gay Democrat from Massachusetts) and Sam Fellows (a Mormon Republican from Arizona), both members of the House Select Intelligence Committee. Later in the series, the oddness of the friendship is explicitly commented upon.
- Peter Pays Tribute has Maggy, a bubbly air-head, befriend a boy who has given up speaking.
- Griboyedov (tall, thin, coldly contemptuous, outwardly stoic, brilliant poet and playwright) and Bulgarin (fat, easily excited, trashy writer and scandalous journalist) in The Death of the Vazir Mukhtar.
- In Percy Jackson and the Olympians - Clarisse and Silena. One's the daughter of Ares, God of War. The other's the daughter of Aphrodite, Goddess of Love.
- Aziraphale and Crowley from Good Omens. The respective representatives of Heaven and Hell on Earth, over the milennia they've become more attached to Earth and each other (not like that) than to their respective sides.
- In Animorphs, Cassie the down-to-earth, Technical Pacifist farm girl is best friends with Rachel, a shopping-obsessed beauty who develops more and more (Dark) Action Girl traits as the series progresses.
- From the same series we have Ax, a stranded alien Straight Man who is nevertheless unintentionally hilarious, and his shorm (best friend) Tobias, an angsty human teenager accidentally stuck in the body of a red-tailed hawk (the two bonding as the "outsiders" of the otherwise human group). For added weirdness, Ax is technically Tobias' uncle as well.
- There's also Jake, the serious and often guilt-laden leader with Marco, a Plucky Comic Relief guy who can also be quite serious and even ruthlessly strategic, but they're comparably milder. K.A. Applegate seems to like this trope, though.
- In Honor Harrington Sphinxians and Treecats have an interspecies friendship for each other.
- Sharpe spends most of his time struggling against evil aristocrat officers, but has a long-standing friendship with one upper-class officer, William Lawford. The two of them were captured together in India and Lawford taught Sharpe to read and write while they were rotting in Tippoo Sultan's dungeons.
- Marasi and Wayne in The Alloy of Law. She's an academic, impoverished noble, logically minded, girly-girl, who's a good shot with a rifle, whilst he's a rough thief who operates on Insane Troll Logic and thoroughly dislikes guns.
- Sherlock Holmes, the brilliant but eccentric detective and his best friend and partner in fighting crime, reasonable and grounded Dr. Watson.
- Bertie Wooster and his Aunt Dahlia. It's especially odd in that Bertie is a gentle sort who can't stand the majority of his aunts, whereas Aunt Dahlia is brusque and inclined to exhibit Tough Love. The two double nicely as Vitriolic Best Buds.
- A very big part of the Circle of Magic series, where four abandoned children find themselves having to live together. Everything from their personalities and backgrounds are different. Sandry is a Spoiled Sweet noble girl, Daja is a pragmatic trader, Tris is a mean bookworm, and Briar is a untrusting ex-street rat. Yet a combination of Sandry's determination to make friends with everyone, surviving multiple disasters and having their minds linked means they're as close as can be.
- The Drowned Cities has Mahlia, a crippled victim of war, and Tool, a Half-Human Hybrid Super Soldier, who earn one another's respect while trying to rescue Mahlia's friend, Mouse, from the soldier boys of the United Patriot Front. By the end of the book it appears that Mahlia and Mouse's sergeant, Ocho, may also be heading this way.
- Tahiri and Nen Yim develope this near the end of the New Jedi Order novels. The former is a snarky, spirited Action Girl wrestling with the lingering effects of Yuuzhan Vong experimentation and brainwashing; the latter is a reserved, driven scientific prodigy who was one of the one's responsible for said experimenting and brainwashing. They start off understandably hostile, but rather quickly develop a surprisingly strong rapport. The fact that Tahiri's Vong memories were adapted from Nen's in the first place undoubtedly helped, since it meant there was much in their subconsciousness that would have been the same.
- Will and Jem from Infernal Devices.
- Will and Magnus, considering that Will doesn't really do friends and that, up until that point, Magnus hated Shadowhunters.
- In Clockwork Princess Magnus and Henry seem to get along swimmingly. Magnus is the only person other than Charlotte to ever consider Henry brilliant and Henry introduced Magnus to glitter, his semi-infamous accessory from the Mortal Instruments series.
- Sixty Eight Rooms: Jack and Ruthie were desctibed as being opposites.
- Tales of Dunk and Egg by George R. R. Martin chronicles the oddest of friendships between Dunk, a former Street Urchin turned Knight Errant and his squire, Egg secretly Prince Aegon of the Targaryen Dynasty.
- In The Nexus Series: Rangan, a rich Neuroscience grad-student who's also a popular DJ, becomes fast friends with Bobby, a 12 year old boy with Autism. It helps that they are both running Nexus 5 and can communicate via emotions and thoughts through a shielding flaw in the prison they are both being held at.
- In The Underland Chronicles, calling Vikus’ relationship with Ripred a "friendship" is a little strong, but the two do have more respect for each other than the other members of their species.
Live Action TV
- One of the most popular tag teams in WWF/WWE history was the Rock 'n' Sock Connection which consisted of The Rock and Mick "Mankind" Foley. The former was a hip, electrifying, good looking young man with a bit of a bullying streak. The latter was an overweight, scraggly dork who took every opportunity to look "uncool" as possible (to the point of using a dirty sock as a puppet named Socko, hence the "Sock" part of the team name). Despite their very obvious differences (which included a very, VERY vicious feud earlier in the year), their chemistry as both a tag team and a comedy duo was undeniable and led to THE most highly rated segment in WWE Raw history. The Rock originally had a tolerable disdain but grew to respect and like Mick as time went on. Though the actual team-up was relatively short-lived, the two have since become kayfabe best friends. In fact, the first time the Rock returned to the ring after his semi-retirement in 2003 was to come to the aid of Mick against Evolution.
- The friendship between WCW Professional Wrestlers Sting and Lex Luger was often portrayed this way, as Sting was a Face and Luger was (more often than not) a Heel.
- The team of Booker T and Goldust (also known as "BookDust") was this in spades throughout 2002 to 2003, with Booker as a brash, short-tempered, and cocky heel, and Goldust as a perverse, bizarre, and persuasive face. Upon meeting for the first time, Booker couldn't stand being near Goldust, but the duo eventually clicked once Booker begun his feud with the nWo. After some initial skepticism, Booker eventually warmed up to Goldust, and both of them were featured in many comedic backstage segments where they both dressed up in silly outfits or parodied other wrestlers. The team broke up after losing a match with that as a stipulation, but from time-to-time (depending on if Goldust is with WWE or not) there's usually one segment that reminisces about the tag team whenever Booker and Goldust are in the same room or in the ring at the same time.
- The stoic, soft spoken, respectful, always serious "World Warrior" Low Ki and the loud, vicious, obnoxious and fun loving "Notorious 187" Homicide are the best of buds. This may stem from Homicide being one of Low Ki's trainers but that just begs the question of just how Low Ki turned out the way he did, as most of Homicide's other students are much more in line with his personality, with the exception of Rycklon, and none are as close to him. Also, "Kaval", who was essentially Low Ki in all but name and his NXT mentors Lay Cool, a pair of mean spirited, shallow, self absorbed airheads. They didn't treat Kaval with much respect but that's just how they are, they did genuinely like him and he reciprocated. A lot of fans don't like that Kaval and Laycool were paired up but the man himself enjoyed working with them (even if he didn't like being on NXT).
- Career driven Uzuki Yashiro and laid back Koki Kariya in The World Ends with You.
- Technical Pacifist Mega Man X and Zero. They are created by two rival scientists, Dr. Light and Dr. Wily, respectively, and add the fact that Zero is supposedly designed for the purpose of destroying X.
- Gorath and Owyn from Betrayal at Krondor certainly qualify. A taciturn 260-ish dark elf clan chieftain and a bubbly 19-year-old human mage apprentice?
- Ezio and Leonardo Da Vinci in Assassin's Creed II. At one point in the game Leonardo even gives Ezio a bro-hug.
- Leon and Yuffie in the Kingdom Hearts series.
- Dissidia: Final Fantasy has so many odd friendships, it requires a list onto itself.
- In Neverwinter Nights: Hordes of the Underdark, Deekin makes friends with everyone. Even the tiefling scared of his Unstoppable Rage. Even the reformed Drow assassin. Everyone.
- In Tales of Arterra, your entire party. Persey is a Succubus, Evanine is half-celestial and on the extreme-altruist end of Neutral Good besides, and Montador is an unexpectedly chivalrous Blood Knight. And yet they all end up the best of friends.
- Most notably Bran and Rizzen, but also possibly Vico and the Princess, Rizzen and the Princess and Rizzen and Pia in A Dance with Rogues. For that matter, seeing as most of the group joins up to help out the Princess and most don't really like anyone else, the entire group counts.
- Khelgar and Neeshka or Elanee in Neverwinter Nights 2, so long as you get his influence high enough to mitigate his Fantastic Racism.
- Lawful!Knight-Captain and Neeshka; she has a tendency to grumble that she doesn't understand him/her at all yet still sticks her neck out for her boss on numerous occasions.
- Chaotic!Knight-Captain and Safiya in Mask of the Betrayer, especially apparent whenever the Knight-Captain makes a silly remark.
- Mission, the Cute Monster Girl Classy Cat-Burglar, and Zaalbar the proud Wookie of Knights of the Old Republic. Also, the player character (basically a hired mercenary and is discovered to be a mind-wiped evil villain) with anybody, except maybe Canderous and HK-47.
- Shepard of the Mass Effect series with pretty much anybody apart from Ashley and Kaidan (fellow Alliance Marines - work friends, basically) and maybe Jacob and Garrus. Mercenaries, an elderly asari, a near-sociopathic biotic, a deeply religious drell assassin, even a krogan clone.
- Shepard and Liara isn't at all far-fetched. Pressly and Tali, on the other hand...
- Joker and EDI, at least after EDI's blocks are removed and she takes over the Normandy. The two even get a Relationship Upgrade in the third game after EDI acquires a Fembot body.
- Miranda and anyone, given her usual attitude towards friendship. Especially Jack when they reach Vitriolic Best Buds status in the Citadel DLC for 3, given that in the second game they come very close to killing each other at least once, possibly more often.
- Tali and Legion as the latter comes from the race that tried to wipe out Tali's people 300 years earlier, and the former does show signs of still being bitter about that.
- In the third game, Mordin and Wrex (if they're alive) get along surprisingly well, especially considering the fact that Mordin was responsible for upgrading the Genophage that drove the Krogans to near-extinction. At the end of the Tuchanka arc, if Mordin sacrifices himself to disperse the Genophage cure, Wrex suggests naming one of his and Eve's newborns after him (maybe a daughter).
- Assuming they meet in the Citadel DLC, Javik and Zaeed become friends. The fact that Javik is a Precursor Galactic Conqueror minus an army who looks down on everyone, the idea he becomes friends with anyone is surprising.
- Wrex and Garrus, given that the krogan relationship with turians has hovered somewhere around "simmering hostility" for a millennium and a half. Given that the krogan had reached the moons of the turian homeworld when the turians deployed the genophage, it's hardly surprising that both sides would cheerfully strangle each other, and yet:
Wrex: Damn it, out of all of the turians out there, I had to make friends with one who thinks he's funny.
Garrus: Well how do you think I feel? I'm supposed to hate you, but instead you warmed my heart with your winning personality.
Wrex: I could throw a few salarians off a cliff if it'll make you feel better.
- Ataru and Usagi from Mr. Driller; one is a human and the latter is an Alien bunny whose original mission was to invade earth, but then his ship crashed and Ataru saved his life.
- Genis and Lloyd from Tales of Symphonia. The genius child prodigy and the village idiot, somehow being such good friends that when Lloyd is Banished, Genis demands to be exiled with him.
- Estelle and Rita from Tales of Vesperia. A prim and proper book-smart princess with little worldly experience, and an aggressive mage who's big on getting stuff done on her own when no one can help.
- In Baldur's Gate 2 CHARNAME can strike up a friendship with a surprisingly cordial beholder. It helps that said beholder is a Lawful Neutral Deadpan Snarker instead of an Ax-Crazy monster like most of his kin.
- Most characters from Dragon Age: Origins make pretty odd friends with at least one other party member.
- Morrigan and just about anybody given her admitted "difficulties" with forming friendships. Especially evident with a more noble-minded male Warden who does not start her romance.
- If both are recruited and survive to the end of the game, Wynne and Shale form one of these. They even travel to the Tevinter Imperium together to find a way to restore Shale to mortal form. They're apparently still friends during the events of Asunder until Wynne dies.
- Sten is an odd one as well. Leliana seems genuinely curious about him and his people, and is able to call him a softy with little more reaction than a mild grumble; he enjoys her singing and surprisingly doesn't harass her about being a devout Andrastian, despite atheism being built into the Qunari language. Alistair also admits that Sten isn't as bad as he'd expect, and though the game doesn't show Sten thinking too highly of Alistair in return, Those Who Speak reveals he's warmed up enough to call him kadan. Sten and Ogren also engage in some friendly verbal sparring; bonus points to this one for the two of them being the tallest and shortest members of your party by a good margin.
- Zevran was originally hired to kill the Warden. Naturally, this can result in a bit of tension, though to him it was all just business, Nothing Personal.
- Just about any of the friendships between your allies in Dragon Age II. A possible odd friendship between the PC and one of his/her allies is a mage Hawke with the mage hating elf Fenris if you decide to pursue a friendship.
Aveline: Not now, Hawke!
- The Medic and the Heavy from Team Fortress 2 are widely known as being closer than any of the other classes - mostly because of how well they work together in battle, and several in-game lines coming from the Heavy (offering to take bullets for the Medic with "Get behind me, doctor!", "You are great doctor!", "I love this doctor!"). One of them is a German doctor implied to hail from the Nazi era (although he's confirmed as not being involved with the party), exhibiting fairly Camp mannerisms, the other a Russian testosterone-poisoned Boisterous Bruiser who enjoys calling everyone and anyone "cowards" and "babies". How strong is the Heavy's fondness of the Medic? The Medic calls the Heavy a baby in the "Meet the Medic" video ''while pinching his cheek''. Not only does he survive, he actually comes out of it without a scratch.
- Another example is the Pyro and The Engineer. Like Heavy and Medic, their personalities appear to be opposites, but they appear to be close friends in and out of battle. Pyro is a Cloudcuckoolander, and Engineer is a down-home Southern-Fried Genius who appears to be the Cloudcuckoolander's Minder. Even knowing the Pyro is, well, a Pyro Maniac, he still invites him to his house and reads him a Christmas story in one update comic.
- Resident Evil gives us a villainous example with Albert Wesker and William Birkin. Wesker's a physically imposing Badass who wears his Sunglasses at Night, and rarely emotes unless it's time for a scenery chewing speech. Birkin's a skinny Mad Scientist who panics easily and rarely stops talking. Wesker is likely asexual; Birkin is Happily Married and has a young daughter whom he honestly seems to care about. Wesker did Umbrella's wetwork before jumping ship; Birkin's their top researcher and almost never leaves the lab. Wesker is confident of his own superiority; Birkin's a paranoid who constantly needs to reinforce his ego. Yet despite all that (and their shared sociopathy), there is every indication that they maintained a genuine friendship, having been college buddies, coworkers, and Those Two Bad Guys prior to Wesker's defection and Birkin's subsequent mutation and death. As late as Wesker's Report, the typically unemotional Wesker expresses both extreme distaste for Birkin's killer, U.S.S. agent HUNK, and a continued respect for his former colleague's ability, which is unusual for him.
- In the Soul Series, Tira is an Axe Crazy servant of Nightmare, while Pyrrha is Purity Personified, much like her mother, Sophitia. Not to mention the fact that Tira kidnapped Pyrrha when she was only a child after framing her for murder. Despite this, and despite the fact that Pyrrha at first refuses to actually work with Tira, she often considers her the only friend she has. Unfortunately, Tira only uses this to her advantage, and eventually convinces Pyrrha to become Soul Edge's next host.
- If Mortal Kombat Deadly Alliance is indication, Goro and Kitana are old friends, to the point that she attended his funeral at Kuatan Palace to mourn for him after he was slain by Noob Saibot sometime between 4 and DA.
- Neil and Eva from To the Moon, though some people view them as more than "friends".
- In The King of Fighters, Shen Woo is a Blood Knight while Duo Lon is a Princely Young Man. They're still as close as their clashing personalities and goals allow.
- Street Fighter gives us Dan and Sakura. Dan is the original Joke Character. Sakura is a young girl who, frankly, could kick Dan's face in without trying. Dan is under the delusion that he's Sakura's teacher. She seems to genuinely like him despite this and plays along with it. The two of them are also friends with Blanka, the green beast man.
- In the Reverie DLC for Castlevania: Lords of Shadow, we have Gabriel and Laura. He's a gruff monster hunter who was tasked in the main game with slaying the titular Lords of Shadow, one of whom was Laura's vampire "mother" Carmilla. She's a vampire who, not long ago, was trying to kill him. Yet somehow over the course of Reverie, they form a sufficiently close friendship that, after Laura's death, Gabriel goes on to build a tomb for her in the castle, right next to the one housing his beloved wife.
- Tsukihime: Arcueid and Ciel are described in canon as having a 'weird friendship.' One is a vampire. The other is a vampire killer. They also have a bit of a love triangle over poor Shiki, who only attracts the insane.
- Melty Blood has the Back Alley Alliance, starting with Satsuki Yumizuka (normal girl who got turned into a vampire but won big in the Superpower Lottery by becoming a fast-adjusted Unskilled, but Strong Dead Apostle) and Sion Eltnam Atlasia (brilliant mage whose modus operendi is Awesomeness by Analysis and seeking a cure for vampirism, thanks to her own affliction from fighting the Night of Wallachia). Sometimes Len (Cute Mute cat dream familiar) hangs around. Actress Again brings in Riesbyfe Stridberg (Church Executor who fought the Night of Wallachia alongside Sion and died in that battle - the being that exists in the present day as Riesbyfe is a recreated copy) who is a very close friend of Sion (mages and the Church do not usually get along).
- Kiyotaka Ishimaru and Mondo Oowada from Dangan Ronpa. One is a school hall monitor who values school discipline and students' morals above all else, the other is a delinquent who happens to be the leader of the largest motorcycle gang in all of Japan. Despite this, they become close friends due to their mutual passion of being Hot-Blooded. When he is revealed as the murderer in Chapter 2, Ishimaru refuses to believe that Oowada killed Chihiro, but then he is confronted with the truth and has a Heroic BSOD after that.
- Seeing that Ishimaru sees Oowada as his Only Friend, this is justified: he was so focused on his school's morals and rules and encouraging them to studying hard, he never had any friends, even from his group of classmates, until Oowada came along. And when Oowada was executed, he felt like he lost his brother.
- Rabbit and Vinnie from the horror comic Skins. Rabbit is a Pretty Boy vampire who treats life like a candystore and Vinnie is a hulking monosyllabic werewolf soldier who views it more as a barfight.
- Hell, even Jordan and Rabbit fit this trope. She's a driven workaholic psychic commander and Rabbit is...Rabbit. Yet they're best friends and possibly also lovers.
- Finas and Casimiro of Hanna Is Not a Boy's Name are complete opposites in every way, yet the two have been practically inseparable for centuries.
- Veser and Ples may also be headed this way.
- They fancy themselves an Odd Couple, but Elan and Thog from The Order of the Stick get along famously.
- Also, more recently, O-Chul and The Monster in the Darkness.
- Richard and Cale'Anon from Looking for Group, one is a sociopathic undead warlock who is probably only helping the heroes out of boredom, the other is an overly idealistic elven paladin who doesn't know he's supposed to be evil and does his best to be a Friend to All Living Things.
- Kiki and Bun-Bun from Sluggy Freelance. Aside from both being Talking Animals, they don't have much in common: one's a Genki Girl with Incorruptible Pure Pureness, the other's a Killer Rabbit and Sociopathic Hero who is strictly apathetic towards just about everything. Despite this, Kiki considers Bun-Bun her best friend, and Bun-Bun hasn't killed Kiki (and in fact is unable to do it even when he gets pissed off), which is about as friendly as Bun-Bun gets with anyone.
- Obsessive-compulsive Hannelore and the hygiene-challenged Marigold from Questionable Content.
- In El Goonish Shive, the Straw Feminist Susan and the Chivalrous Pervert Tedd.
- Homestuck has The Fool John and base-breaking Backstabber Vriska.
- Also Equius and his moirail Nepeta: he's serious, stubborn and obsessed with caste and dignity, while she's an RP-loving wildchild who hunts down vicious animals with her bare claws. Despite their odd relationship, the two are clearly very close. When Gamzee loses his marbles and turns homicidal, the first thing Equius does is make sure Nepeta is safe.
- All over the place in Dumbing of Age. Danny and Joe are a long-established pair. Joyce and Walky and Joyce and Billy are developing ones.
- In The Fuzzy Five, room mates Britnee the perky blonde and Meredith the Goth.
- Bloody Urban has Libby Neon- nihilist, Conspiracy Theorist and hardcore vegetarian- and her roommate Angelica Pasternak-a perpetually cheerful airhead with a serious Bacon Addiction.
- Both of the main friendships in Gunnerkrigg Court are this:
- Annie and Kat are close friends despite being complete opposites personality-wise. They also metaphorically represent two opposing forces (the forest and etherical things for Annie / the court and technological things for Kat).
- Annie and Reynardine, who are, respectively, a quiet young girl and a fox god. Reynard has killed at least one human and a dragon via glitched Body Surfing, and (may have) tried to kill Annie the same way, but this doesn't bother her much. Even the awkwardness of Reynard being in unrequited love with Annie's mother, along with the revelation that Annie is basically her mother's reincarnation, isn't enough to hurt their friendship more than temporarily.
- As if that's not enough, we now have Shadow 2 and Robot, who have no similarities other than being named by Captain Obvious. One is a shadow-man created by Coyote as a half-assed representation of humanity, and the other is a misbehaving robot who often receives severe sword injuries. They don't fight crime, but they are together.
- In Harbourmaster, when Partasah died, his daughter Gilou tried to force Tal, the governor Partasah chose, to abdicate in his favor. Instead, she ended up being hired as his assistant ... only to discover herself beginning to like him.
- Most of the heartwarming character interactions in Brawl in the Family can be chalked up to this, mostly via King Dedede and his tortured friendships with erstwhile enemies Kirby, Meta Knight, Bandana Dee, and Adeline.
- A number of Survival of the Fittest examples, including Adam Dodd and Julie Mikan, as well as Sean O'Cann and Trish McCarroll. Both friendships are highly circumstantial, however.
- Cracked just did an article about this very topic. 
- Jack Raven and Michael Freeman from Behind The Veil. The former is an ex-assassin who hunts evil to make up for his own sins, while the latter is an ex-fire fighter who hunts evil to protect people. Despite first meeting only to defeat a monster, the two stuck together and became best friends.
- It is even noted about Sasha Hunter and Iphigenie Leben in Greek Ninja that the two are unlikely friends. You've got Sasha, the tall, cool, brooding and people-hating ninja hanging out with Iphigenie, the small, cute, cheerful philosophically-inclined thinker.
- Despite The Nostalgia Critic's unhappiness with the Chick's stalking of Todd in the Shadows, the boys go for eyebrow waxings together.
- The Clockwork Castle episode of the Mario Party TV series sparked the Running Gag of Toadette and DK being good buddies, due to how many times she got to catch him.
- In I'm a Marvel... And I'm a DC, take the Rorshach and Deadpool examples from under Comic Books. Seriously. They even got their own web series.
- Worm gives us Taylor Hebert and Rachel Lindt — an intelligent and idealistic bullied teenager and a violent Book Dumb delinquent, respectively.
- There's also Imp - a Nominal Hero teenaged girl in it for the thrills and violence and Vista, a younger girl who takes her heroing seriously.
- The RWBY episode Emerald Forest'' lampshades this. When Jaune and Pyrrha partner up, Glynda remarks that they won't do well together. Despite this, the trope is played straight; Jaune admires Pyrrha's strength and kindness, she envies his social resilience and comfort with civilian life.
- Another example is Weiss's friendship with Ruby. Ruby is compassionate, mischievous, and can barely focus on schoolwork; Weiss is a proud, disciplined aristocrat eager to prove her academic prowess. Yet- after much initial bickering- they easily play and fight together.
- The large, uncoordinated Bulkhead and the stoic ninja Prowl in Transformers Animated.
- Prowl and Bumblebee even more so.
- To say nothing of the gruff Ratchet and the idealistic Optimus. Course, Ratchet being friends with anybody just seems odd.
- Ratchet in Transformers Prime is nearly as crotchety as his Animated counterpart, but his friendship with Optimus Prime goes back to long before the latter became a Prime. Ratchet also didn't care much for humans in the beginning, but managed to establish his own friendship with Raf (even though Bumblebee is Raf's nominal partner).
- Of the Autobot-human partnerships, Arcee and Jack seem the least likely to get along, and neither are thrilled with the pair-up at first.
- Agent Fowler and Bulkhead. Fowler didn't get along with any of Team Prime at first, and Bulkhead even called Fowler a jerk (and was willing to leave him in Decepticon hands, until Jack called him out), but the two could now be described as Vitriolic Best Buds - they'll still toss insults to each other, but the respect is there.
- Most of the Justice League, but in particular the core seven, and in particular of those seven Green Lantern and Flash.
- Stewie and Brian Griffin in Family Guy. Pretty much self evident.
- Down to earth sporty girl Francine and rich girly-girl Muffy in Arthur are an example of this.
- Total Drama Island:
- Lindsay and Beth. The former is a popular and very attractive rich girl, while the latter is a short, homely geek who was raised on a farm.
- Despite being complete opposites, Owen and Noah are very fond of each other.
- In the TDI special, Noah, Izzy and Eva team up together and had enough chemistry that Team Escope became a popular fandom grouping.
- Though they don't get as much attention, cool biker guy Trent with Extraverted Nerd Cody, especially since they were unwittingly part of a Love Triangle early on. This could theoretically be extended to the other Drama Brothers as well.
- Extraverted Nerd Harold and Lovable Jock Tyler form a brief friendship in World Tour after discovering their mutual love for Japanese game shows.
- Fievel and Tiger in An American Tail become friends despite being a mouse and a cat respectively, and then sing a song about it.
- Mai and Ty Lee from Avatar: The Last Airbender. They have polar opposite personalities, and you'd never pair them up as best friends, but that's what they are. Ty Lee is very glompy with Mai, but Mai usually returns the embrace.
- Appa and Momo, a ten-ton sky bison and a five-pound flying lemur the size of one of his toes, share a very close bond. Maybe it helps that they're some of the last survivors of the Air Nomad culture.
- Toph and Iroh. The blind earthbending tomboy and the brother of the Fire Lord. Doubles as Intergenerational Friendship.
- Phineas and Ferb gives us the oddly sympathetic bully Buford and Bollywood Nerd Baljeet, the usual target of his bullying. They even have a song where they describe themselves as "Frenemies".
- Straight Man Henry and bossy June on KaBlam!.
- Egotistical, mousy Peggy Hill and beautiful, seductive Nancy Hicks Gribble on King of the Hill. Kind of Fridge Brilliance, since the only reason they may be friends is because their husbands are friends.
- And both of them with snooty Mihn, though she'll profess to dislike them often.
- King of the Hill is all about this, considering the core four friends include the severely buttoned-down, straight-laced family man Hank, unhinged but ineffectual and sweet-tempered conspiracy nut Dale, desperate, divorced, bumbling Butt Monkey Bill, and suave serial philanderer Boomhauer. Helps that they all went to High School together, but the fact that their friendship endured as they evolved into very, very different people speaks to this trope.
- On Adventure Time, Kid Hero Finn with Marceline, a thousand-year-old teenage-looking vampire queen.
- Also the volatile Flame Princess and dimwitted Cinnamon Bun. She likes him because he's open and honest. She even brings Cinnamon Bun with her when she stages a coup of the Fire Kingdom.
- God and Satan in God, the Devil and Bob take this trope Up to Eleven. The offbeat interpretations of the characters help - God is an ageing hippie, the Devil is Ambiguously Gay and Affably Evil. Borders on Friendly Enemy, though they're never quite vitriolic enough to make the leap.
- SpongeBob is a neat freak and generally has a well-ordered life; Patrick…is not.
- Depending on the Writer in Spongebob's case; certain episodes portray him as a neurotic neat freak while in others he's shown to be just about as careless as Patrick.
- Despite being a cat and a goldfish, Gumball and Darwin of The Amazing World of Gumball aren't just best friends but also brothers. Making it odder is that Darwin used to be Gumball's pet goldfish before gaining limbs and intelligence like most things in Elmore. When asked where he got the idea of a cat and goldfish duo, the show's creator replied that if a cat can be a dog's sidekick he figured a fish would be a cat's sidekick.
- Idiot Hero Tak and Only Sane Man Jeera from Tak and the Power of Juju.
- Edward and the Unintelliance Chip and Skip from Camp Lazlo.
- From Ed, Edd n Eddy we have Ed, a Cloud Cuckoolander who's as strong as a forklift and half as smart, and Edd, an obsessive-compulsive Gadgeteer Genius Neat Freak. It probably helps to have Eddy there as a buffer.
- In W.I.T.C.H., Caleb is friends with Blunk.
- As mentioned in the page quote, Walter "Wally" Ford and Kevin Hill from Mission Hill. Wally is an elderly gay man in a long-term relationship with his partner of many years, Gus, and Kevin is a young, straight, socially-awkward virgin who pushes away thoughts of relationships in hopes of getting into a good college. Wally is a projectionist at the local theatre, and one week, while they're running X-Rated films, Covert Pervert Kevin sneaks in, only to discover what they're showing isn't porn, but rather, Midnight Cowboy. Their friendship seems to turn Kevin into a major film buff.
- From My Little Pony: Friendship Is Magic, one wouldn't expect most of the Mane Cast to have anything to do with the other. Indeed, prior to the beginning of the series, most of them didn't seem more than vaguely aware of the others. Still, a few stick out.
- Rainbow Dash can't get enough of daredevil stunts and thrills, while Fluttershy is afraid of heights, crowds, and loud noises, among other things. They've known each other since they were foals, hang out all the time, and Rainbow Dash once broke into Fluttershy's cottage just so they could go get cider together.
- Applejack is a down-to-earth farm worker that loves competing in rodeos. Rarity is a dressmaker that dreams of getting into high society. Indeed, at first, they seemed to absolutely hate each other — but after a great deal of Character Development, its clear how much they care.
- Twilight Sparkle is an introverted scholar who literally had to be coerced into making friends to combat the threat of The Night That Never Ends. Pinkie Pie is a manic extrovert, whose inability to shut off or slow down poses the danger of turning off most ponies (most notably the quick-tempered Rainbow Dash, who now counts Pinkie as one of her closest friends).
- Later down the road we get Discord, the master of chaos and main antagonist from "Return To Harmony", and timid Fluttershy.
- In The Land Before Time, we have a soft spoken Apatosaurus, a hot headed Triceratops, a happy-go lucky Hadrosaur, a panicky Pteranodon, and a mute Stegosaurus somehow makeing a cohesive and tight-knit group.
- It gets even more bizarre when a friendly Tyrannosaurus and a whimsical Oviraptor get added to the crew.
- From Garfield and Friends/U.S.Acres, we have The Prankster Jerk with a Heart of Gold Roy Rooster and Lovable Coward Wade Duck. Even when Roy scares him, and they argue sometimes, they became closer friends later on in the seasons.
- In Sym-Bionic Titan, nerdy Newton (Octus) ends up getting along quite well with the Dumb Jock nicknamed Meat.
- Sam and Tucker from Danny Phantom, one is a meat loving technogeek and the other is a vegetarian Perky Goth. But yet they have been best friends with Danny since they were kids.
- Bad Seeds stars Harvey, a sweet-natured , quiet bird, and twin orphans Fee and Foo, two wild troublemakers. They are the best of friends.
- There are many examples of this among animals:
- Owen and Mzee, the hippo and tortoise
- There was one example in India where a cow and a large wildcat became inseparable friends. The villagers ended up tolerating the wildcat because it's presence scared away other creatures that could be a threat to their farm.
- A few examples.
- In a way, not only herding dogs (which are bred and taught to herd sheep or cattle) but also many other kinds of farm dogs who learn to protect and defend other farm animals such as chickens (such as watching over them, stopping them from wandering too far away from the farm, and driving predatory wild animals away.)
- The current trope image features Tommy the Golden Retriever and Salati the leopard.
- Boxers Max Schmeling and Joe Louis. They fought each other twice, and Louis was a very patriotic African-American while Schmeling was lionized by the Nazi party. (Until he fell out of favor due to a high profile loss and sheltering Jews.) Many years after fighting each other, they became quite close friends. Schmeling even served as a pallbearer for Louis's funeral.
- Kanye West is friends with La Roux, Elton John and Justin Bieber.
- Malcolm Fraser and Gough Whitlam. In 1975, Fraser exploited a situation to get Whitlam sacked, and then took over his job. Which doesn't sound so bad, until you know that the job in question was Prime Minister of Australia, and that the incident in question is the Australian Constitutional Crisis of 1975. The two cordially hated each other for years thereafter, but by the late Nineties, they'd made up their differences - despite being from diametrically opposed parties, they weren't actually that far apart on the issues - and united against a common enemy: the then-current Australian Prime Minister, John Howard.
- Speaking of John Howard, he too appears to have developed an Odd Friendship with one of his fellow former PM's — Labor Prime Minister Bob Hawke, who defeated Howard in the 1987 election. They also share an enemy: Hawke's former treasurer Paul Keating, who rolled him for the Prime Ministership in 1991, and who Howard defeated in the 1996 election.
- Apparently Chuck Norris and Justin Bieber, but you be the judge.
- Gloria Vanderbilt is very good friends with Kathy Griffin —much to the bewilderment of Gloria's son, Anderson Cooper. Gloria Vanderbilt is basically the closest thing the U.S. has to nobility, and Kathy Griffin is, well... Kathy Griffin.
- Eminem and Elton John
- Jay-Z and Beyoncé go on double-dates with Chris Martin and Gwyneth Paltrow.
- Billy Ray Cyrus and Kurt Cobain, as explained in this article, which makes the backlash over Billy Ray's daughter covering "Smells Like Teen Spirit" in concert all the stranger.
- Cobain was also good friends with author William S. Burroughs, despite their age difference. Burroughs even introduced Cobain to Leadbelly's music, hence giving the world Cobain's famous rendition of Where Did You Sleep Last Night
- Brad Paisley and William Shatner. Also, Shatner and Ben Folds.
- Loud, brash, urban party-boy Wolfgang Amadeus Mozart and quiet, nature-loving family man Joseph Haydn had a long, profitable correspondence, and shared a great deal of mutual respect. Mozart even dedicated a suite of string quartets to Haydn. Overlaps with Intergenerational Friendship, as Haydn was nearly thirty years older than Mozart.
- Mel Gibson, an ultraconservative traditionalist Catholic, is very good friends with Jodie Foster, a lesbian atheist, and Robert Downey, Jr., a self-described "Jewish-Buddhist". The latter two have stuck with Gibson even in the midst of his drunken antisemitic episode and the resulting public backlash, with Downey Jr. asking that people cut him some slack.
- In the 80's to early 90's, Creator/Howard Stern and Richard Simmons.
- Robert Pattinson and Death Grips.
- Tony Bennett and Lady Gaga.
- Groucho Marx maintained a lengthy correspondence with poet T. S. Eliot, the two eventually becoming close friends. Marx also was, during the latter days of his life, friends with Elton John and Alice Cooper.
- Miley Cyrus and Snoop Dogg.
- Mark Twain with Joshua Norton, and with Nikola Tesla.
- Robert Fripp and Daryl Hall.
- Ozzy Osbourne and Rick Wakeman.
- Frank Zappa with The Monkees. Zappa was also a personal friend of comic strip artist Jack Kirby.
- Tammy Faye Bakker the televangelist and notorious porn star Ron Jeremy became close friends after filming MTV's The Surreal Life together, and after her death, Ron Jeremy spoke of her with respect and affection.
- Harry Chapin and critic Dave Marsh, who frequently slammed acoustic singer-songwriters in his reviews. Marsh interviewed Chapin for Rolling Stone and they realized they had similar political and humanitarian concerns.
- Muhammad Ali and Senator Orrin Hatch (R-Utah). Ali was also good friends with sport journalist Howard Cosell.
- Social Media creates tons of these. It's quite easy for such friendships to form online based around one specific interest like a Fandom or hobby, and things like gender, race, religion, and age don't mean much thanks to the nature of the internet.
- On the US Supreme Court, Justices Antonin Scalia and Ruth Bader Ginsburg are known for their diametrically opposed political and judicial philosophies and their frequent snark wars in opinions. They have a standing lunch date, their families vacation together, and they are fixtures at the opera.
- It's really very common in real life to have a friend or two who you would not expect to be friends with due to the personality or opinions of theirs.
- Demi Lovato and Tony Orlando.
- Kristin Hersh of Throwing Muses became friends with old timey Hollywood actress Betty Hutton when Hersh was 19 and Hutton was in her mid 60s and remained so until Hutton's death 22 years later. There's a Crowning Moment of Funny in Hersh's memoir Rat Girl/Paradoxical Undressing in which Hersh sees the cover of one of Hutton's films in a video store and realises that Hutton's Hollywood career was real and not something she invented in order to distance herself from a past she didn't care to think about.
- This can occur with combat veterans of opposing sides years after the war is over. Examples include certain Pearl Harbor survivors and Japanese pilots who participated in the attack, and various reunions of Civil War veterans.
- France and Britain after 1815. Also the Boxer Rebellion (1900), during which all the European "Great Powers" plus Japan and the United States were allied. They even agreed to a unified command.
- Averted by Kaiser Wilhelm II, who refused to have anything to do with Hitler, and chose to remain in exile in The Netherlands until his death in 1941.
- Outspoken conservative radio personality Rush Limbaugh and outspoken liberal Family Guy creator Seth MacFarlane.
- In the later years of their life Marlon Brando and Michael Jackson were personal friends. Jackson often visited Brando on his private island.
- George Harrison and Eric Idle were good friends. Harrison was a Monty Python fan and even helped the group out financially went they had to find a producer for their film Monty Python's Life of Brian.