Spider-Man 2099 was the first title of Marvel Comics' Marvel 2099 venture.Miguel O'Hara, a geneticist for the Mega Corp. Alchemax, was working on a way to splice a person's genetic codes to give them superpowers. He bases his ideal creation on one of the heroic age's greatest super-heroes, Spider-Man, hoping to create the ultimate "corporate raider". When an experiment goes awry, resulting in the death of the volunteer, Miguel decides to quit. However, his boss, Tyler Stone, tricks him into taking some Rapture, a drug that bonds with the user's genetic structure, so they need it like they need air to breathe. As Alchemax is the only legal supplier of the drug, Stone believes Miguel will have no choice but to stay with Alchemax.Refusing to accept this, Miguel sneaks into his lab that night, hoping to use his genetic imprint (Which he had used as a base in his experiments) to restore him to the way he was before. However, a jealous co-worker sees him, and sabotages the machinery, hoping to kill him. Instead, Miguel emerges with the Spider-Man code, having gained fangs, claws, and enhanced strength and vision.After being forced to run from Alchemax security, Miguel finds himself chased by Venture, a Cyborg sent by Stone to capture him so he can be studied. Donning an outfit he wore for a day of the dead festivel, Miguel takes on Venture, and beats him, signalling the beginning of his career as the Spider-Man of 2099.Although Miguel started off looking for a cure for his condition, he soon realised the horrors Alchemax and the other megacorps had caused the world, and made it his mission to make things better.Spider-Man 2099 was by far the most prolific Marvel 2099 title, with the character surviving long after the franchise's end, appearing in such series as Exiles. After guest-starring in the Superior Spider-Man series, Miguel is set to have his own title once more: Trapped in the present, he works to undermine the fledging Alchemax before it becomes the evil corporation of his time.
Cain and Abel: Miguel's half-brother, Kron Stone, becomes Venom 2099.
Played with in Miguel's half-brother, Gabe. Gabe was originally set up by Peter David as a red herring for the identity of Goblin 2099, but it became canon due to Executive Meddling, playing this trope straight with Miguel and Gabe battling each other. However, 2099: Manifest Destiny later Retconned it so Goblin was a shape-shifter assuming Gabe's identity, averting this trope.
Miguel himself is one in the second series, being as he is now in the "mainstream" Marvel Universe.
Cassandra Truth: When asked who he is by people in the modern day, Miguel just tells them the truth.
Chosen One: Spider-Man 2099 is called the "Herald of Thor", and is prophesied to save the world. Turns out he really was the Chosen One, and was the third person to wield Thor’s Hammer (with Captain America being second.)
Contrasting Sequel Main Character: Miguel is this to the original Spider-Man; Whilst Peter Parker was reserved, and Spidey a wisecracker, Miguel is the opposite, mouthing off as a civilian, while not talking much in his heroic identity.
"Pretty much every place where Stan (Lee) zigged, I zagged... whereas Peter Parker is a high school student, Miguel is a fully-realized adult working in a laboratory. Whereas Peter was shy and reticent and didn’t know how to talk to girls but talky and outgoing as Spider-Man, Miguel O’Hara was a fully-confident wiseacre with a fiancée…and as Spider-Man, relatively mute." —Peter David
Evil Twin: Flipside; he was an inactive Super-Adaptoid with files on various supers, and becomes a combination of Spider-Man and Venom after scanning Miguel. He didn't recognize the new hero, so he turned into the closest approximation of him that he could based on appearance. Oh, and he's pretty much Deadpool.
Fantastic Drug: Rapture is a legal designer drug developed by (and exclusive to) the Alchemax corporation, distributed to employees in order to keep them loyal to the company. A "very high-powered, mind-expanding hallucinogen," it causes the user to feel perfectly calm and collected... unless he tries to fight the drug's effects, in which case it causes him to hallucinate wildly, "seeing monsters everywhere." It also bonds with the user's DNA in short order, becoming so addictive "you need it the way you need air to breathe."
The Chameleon is reimagined as a designer drug that alters the user's DNA and allows largely uncontrollable shapeshifting that, more often than not, results in a slow and agonizing death. It's so volatile that even Alchemax (it's creator) wants nothing more to do with it.
Hot-Blooded: Mig (What do you expect, with him being half-Irish and half-Mexican?)
It's Personal: A Public Eye officer goes against Stone's orders and has his squad fire on Miguel, due to the fact that Miguel had badly cut up his son (also a PE officer) a few weeks before with his talons.
Legacy Character: Besides the title character, there are also 2099 equivalents of Spider-Man foes like the Vulture, Venom, Green Goblin, Chameleon, and... Namor.
My God, What Have I Done?: Miguel briefly experiences this after he lashes out at the Specialist (An agent of Stark-Fujikawa sent to attack him), slitting his throat.
Nice Job Fixing It, Villain: When Miguel tried to remove the Rapture in his system, Aaron Delgato, Miguel's supervisor, sabotaged the attempt with Spider DNA. That wound up bestowing Miguel with spider-powers that would enable him to become one of Alchemax's biggest enemies.
Not Quite Flight: Miguel's cape is made of a material called "light byte" that allows him to catch wind currents and lessen his descents.
Super Reflexes: Unlike his namesake, Spider-Man 2099 does not have a Spider-Senseper se. Instead, he has enhanced perceptions that happen to tune in more quickly to what's pertinent, such as an immediate danger or a general plot point. Unlike Spider-Sense, it's limited by what his senses are focused on, and he could still be caught flat-footed.
The version of Miguel, by coincidence in his late teens, who appears in Timestorm, however, does have the Spider-Sense in addition to the regular Miguel's powers.
Ungrateful Bastard: When Miguel saves the Specialist from falling, the Specialist doesn't halt his attack, instead chiding Miguel for having no killing edge.
Whole Episode Flashback: The first three issues revolve around Miguel reciting his origin to his holographic computer, Lyla.
The 2014 series provides examples of:
Cover Identity Anomaly: Liz Allen manages to piece together Miguel's the most likely candidate to be Spider-Man 2099 because his Social Security Number belong to someone who had already died, and none of his credentials checked out. She did it in the span of a day at that,
Fish Out of Temporal Water: So far Miguel hasn't yet played this straight in vol 2. He doesn't seem too bothered being eighty-five years in the past, or confused by it.
Grandfather Paradox: Miguel tries to stop Tyler Stone from travelling back in time to ensure the creation of Alchemax, and then has to stop the Superior Spider-Man from killing his grandfather Tiberius.
It Runs in the Family: You only need to be around Tiberius Stone for about five seconds to see where his son got it from.
Miguel: Hard to believe he's my grandfather. (Beat) No, wait. It's pretty easy.