Emilys ex-husband, the father of Rory, and an Army Ranger who discovers the existence of the fierce Predators but finds that no one believes they exist.
- Cold Sniper: His role back in the Army. Although the coldness is only on the job, given he has a family.
- Elites Are More Glamorous: A Captain in the U.S. Army's elite 75th Ranger Regiment. Man has seen action on five continents and has over a dozen confirmed kills.
- Only Sane Man: Surprisingly, the government doesn't think he's crazy, but simply passes him off as such to keep the existence of the Predators secret. He is definitely this amongst his Ragtag Bunch of Misfits, however.
- Papa Bear: He claims not to enjoy killing... unless you threaten his son.
- Ranger: Captain in the U.S. Army's 75th Ranger Regiment. As such, he's a bonafide badass with extensive combat credentials.
- Sole Survivor: Of his team at the beginning of the movie, and of his second "team" (minus Bracket) by the end of the movie..
- Stomach of Holding: Does this with the cloaking device before his apprehension. He later goes to the bathroom to bring it back up.
- Unwitting Instigator of Doom: Even if there hadn't been two kill-crazy alien lifeforms looking for the Predator-Killer armor, it being shipped to the house of his autistic son couldn't have ended well. If only Quinn had been keeping up payments on his PO Box...
Gaylord "Nebraska" Williams
A former Marine who enlists in a special Predator-hunting operation headed up by Quinn.
- Bungled Suicide: Shot himself in the head, but didn't quite finish the job.
- Dying Moment of Awesome: Performs a Heroic Sacrifice to take down the Predator's spaceship with guns blazing and a smile on his face.
- Dying Smirk: He takes down the Predator's spaceship with guns blazing and a smile on his face.
- Embarrassing First Name: Quinn even notes he did well in being called Nebraska instead.
- Scary Black Man: He's quite an intimidating presence.
- Smoking Is Cool: Rarely seen without a cigarette.
- Turbine Blender: He willingly does this in a Heroic Sacrifice to bring down the Predator's ship and allow Quinn and Bracket to finish it off.
A former Marine who teams up with Quinn to fight the Predators.
- Mercy Kill: How he and Baxley finish each other off.
- Sad Clown: He uses humor to deal with the fact that he accidentally killed a number of his comrades in a friendly fire incident.
- Semper Fi: His jacket indicates that he's an ex-Marine."C'mon, let's go before these Army guys fuck everything up."
- Torso with a View: The Ultimate Predator fires at him and opens a hole in his abdomen.
A military veteran from the Afghanistan and Iraq wars who is suffering from post-traumatic stress disorder.
A former Marine who teams with several other outsiders, including Quinn, to stop the human-hunting Predators in suburbia.
A former Blackhawk helicopter pilot who has suffered a traumatic brain injury from a crash.
- Half the Man He Used to Be: When the Predator ship's shields start to cover the hull, he does not dive over or under it and is cut in half.
- Stalker with a Crush: Shows signs of this towards Casey, though it's not malicious.
- Throwing Your Sword Always Works: Kills one of Traeger's men with a thrown knife to the chest.
An agent who jails Quinn but later needs his help with fighting the Predators.
- Asshole Victim: An arrogant and corrupt government agent who killed himself with the alien technology he attempted to exploit for his own gains.
- Bad Boss: Immediately tries to have Casey killed when things went wrong during the Fugitive Predator's escape (though to be fair she had stolen its extracted spinal fluid). He also kills his own man after the latter lost his hand to the Predator tech he tried to retrieve, to stop him screaming and giving away their position.
- Big Bad Wannabe: He could barely handle the regular Predator, so when the Ultimate Predator shows up, he's horribly out of his league.
- Composite Character: Of Dillon from the first film and Peter Keyes from the second film, all three characters are corrupt government agents with selfish agendas while both Dillon and Traeger are African-Americans.
- Enemy Mine: Forms one with Quinn upon realizing the threat the Ultimate Predator poses.
- Hoist by His Own Petard: Accidentally blows his own head off with the plasma caster he was using.
- Jerkass Has a Point: Accurately guesses the reasons for the Ultimate Predator's killing the Fugitive, and later on argues against the group splitting up, as he knows from studying Predator encounters it'll take them out one by one if they do.
- Oral Fixation: Is almost always seen chewing some type of gum.
- The Men in Black: He describes his job as 'acquisitions', seemingly of alien lifeforms or evidence."I look up and I catch what falls out of the sky."
- Smug Snake: He thinks he's got everything under control, but he doesn't.
A disgruntled science teacher and biologist who joins the crew's mission.
- Action Girl: Doesn't hesitate to hunt down a Predator with a tranquilizer gun. And during the finale it's her getting the drop on the Ultimate Predator that distracts it long enough for Quinn to finally finish it off.
- Hot Scientist: She's played by Olivia Munn, for God's sake.
- Idiot Ball: For all her intelligence and resourcefulness, Casey decides to steal a vial of spinal fluid from Project Stardust during the Predator's escape. This puts a target on her back as she knows too much.
- Not Good with People: She's a misanthropic animal lover with a dislike for interacting with people.
- You Have Outlived Your Usefulness: When the Predator escapes the Project Stargazer lab, Traeger orders her terminated both because she's seen too much and she's stolen the vial of the Predator's spinal fluid.
The son of Peter Keyes.
- Hollywood Nerd: Unlike his gung-ho government agent father, he's just a meek scientist.
- Like Father, Unlike Son: Unlike his corrupt Jerkass father who ends up as eventual Asshole Victim, Sean is a honest Nice Guy and survives a Predator attack.
- Mauve Shirt: Surprisingly survives when the first Predator breaks containment and slaughters most of the guards and scientists.
- Nice Guy: Unlike his arrogant Jerkass father, Sean is quite pleasant.
- Non-Action Guy: Another contrast to his father is that while Peter had combat skills, Sean does not.
Quinn's ex-wife and the mother to Rory.
- Action Mom: When told her son is in danger, she immediately goes to grab a hunting rifle to go rescue him. Even if Quinn tells her to stay behind, she still gives Stargazer's men a hard time.
- Amicable Exes: While she still dislikes Quinn for being a terrible husband and father, she still sees him as a great soldier and immediately trusts him when he told her straight to her face that an alien is out there hunting their son.
Quinn and Emily's troubled son, who has a form of autism and is bullied in school but becomes a key player in the fight against the Predators due to his preternatural ability to learn languages.
- Disability Superpower: His autism is shown as giving him savant features when he restores chessboards from memory. And then he decodes how a Predator wrist computer works...
- Unwitting Instigator of Doom: His putting on the Predator armor with the intention of wearing it as a Halloween costume not only results in him accidentally blowing up someone's house, it also leads both Predators right to his neighborhood.
- Worthy Opponent: The Ultimate Predator considers him to be this due to his ability to figure out Yautja technology. When he challenges the surviving humans in the end and designates "McKenna" as their leader and his prize, he's talking about Rory not his father Quinn.
- Cool Helmet: As is traditional for Predators, but his has a few new tricks, including the red targeting lasers being able to form a plasma cannon instead of the traditional shoulder setup.
- Disc-One Final Boss: He was set up to the main antagonist of the film. Then the Ultimate Predator shows up...
- Heinz Hybrid: Though to a lesser extent than the Ultimate Predator, he has been genetically augmented with the DNA of countless species — including humans. If what Rory McKenna saw in the Predator mask is any indication, the augmentation was not voluntary.
- Hoist by His Own Petard: Quinn getting hold of his tech leads to the Fugitive getting knocked out by his own weaponry.
- Idiot Ball: Comes to earth to give the humans an advanced suit of armour that will allow them to fight back against his people - but after he crashes the first thing he does is hunt and kill Quinn's team in traditional Predator fashion, leading to his losing his tech and subsequent capture by Stargazer.
- A Lighter Shade of Black: Compared with the Ultimate Predator. Massacres Quinn's military unit and the Stargazer staff without mercy - but thereafter he avoids killing the Loonies when he easily could (he even fires a warning shot from his shoulder cannon), and only threatens Rory to get the others to give him back his tech. It's revealed that he's — nominally at least — on the side of the humans, having gone rogue to deliver an advanced suit of weaponized combat armor to Earth.
- Noble Demon: Has genuinely good intentions - slipping the humans a suit of powered armour so they can defend themselves against the oncoming Predator invasion - but still kills a lot of people along the way and poses almost as much of a problem for the Vets in the first half of the film as the Ultimate Predator does in the second.
- Powered Armor: The Predator's body armor covers far more of his body than the Predators from the previous films, and is seemingly more technologically advanced.
- To Serve Man: When escaping the Project Stargazer lab he grabs one of the scientists' arms with his mandibles and then bites a chunk out of it.
- The Worf Effect: While this Predator easily manhandles humans, the Ultimate Predator makes his entrance by neck lifting the Predator, shrugging off his attacks, and caving his head in with a single blow.
- An Arm and a Leg: Rory accidentally activates his ship's force field while he is outside, severing his arm. Later, an explosion blows off his other arm and both his legs.
- Arm Cannon: His Plasma Caster and spear launcher are arm-mounted.
- Barehanded Blade Block: Does this to the Fugitive Predator with such force it actually shatters the smaller Preator's wrist blades.
- Big Bad: The true antagonist of the film.
- Blood Knight: In the film's finale, he challenges the humans to a hunt, intending to claim Rory as a trophy.
- Boom, Headshot!: Quinn delivers the Coup de Grâce by shooting the Predator in the head several times with his pistol.
- Curb-Stomp Battle: It utterly demolishes its regular counterpart in a fight, easily tossing him around and caving his head in within seconds.
- Cyborg: His eyes appear to be technologically augmented, since he doesn't need to wear a mask to lock onto targets.
- Evil Is Bigger: The Ultimate Predator is eleven feet tall and has digitigrade feet, towering over the seven foot-tall regular Predator.
- The Heavy: He's acting on behalf of his superiors, who sent him to dispatch the rogue Predator and recover the Predator-Killer suit.
- Hoist by His Own Petard: How the Predator is defeated at the end; it has its arm cut off by his ship's forcefield, one of his hounds sided with the humans and is stabbed by his own wrist blade launched from his own arm.
- Hunter of His Own Kind: He was dispatched to execute the regular Predator, who had stolen a suit of advanced body armor to give to the humans.
- Immune to Bullets: The Predators from the previous films were a lot tougher than humans and could shrug off a few stray hits, but they were still organic beings and a couple shotgun blasts to the torso was still at least a moderately serious injury to one. The Ultimate Predator is a cyborg with some sort of sub-dermal armor that lets him laugh off assault rifle fire like it's nothing.
- Knight of Cerebus: The movie's hardly a comedy, but there's at least a few laughs and bonding moments with the Loonies. Things get much grimmer when the Ultimate Predator shows up, particularly during the climax when it announces it's going to hunt and kill the Loonies and Stargazer guys alike.
- Punch-Clock Villain: Once he's accomplished his goals (destroying the Fugitive Predator's ship and kidnapping Rory) he elects to simply leave the planet without dealing with the surviving humans and return to his home planet, implying that he's more goal-orientated than anything else. Ironically turns out to be his downfall, as if he'd stayed and killed Quinn and the other surviving humans there'd have been nothing between him and freedom.
- Rabid Cop: Played with. Given that he's implied to be some form of Space Police, he comes across as this due to barely interrogating the other Predator about the stolen technology before killing him via smashing his head in. There's also how he stated he enjoyed watching Rory's Ragtag Bunch of Misfits and the corrupt government agency kill each other. On the other hand, if he is law enforcement, he'd have to be hardcore to keep order when the average member of society is a 7-foot killing machine and they're a Proud Warrior Race.
- Sadist: Blows off Lynch's arm when it easily could have shot him in the back of the head while cloaked (it deliberately shifts aim), and later admits in its message it enjoyed seeing the humans kill each other.
- Super Toughness: In addition to his sparse body armor, he can manifest an exoskeleton underneath his skin that makes him capable of casually shrugging off gunfire and even shattering the normal Predator's wrist blades.
- To Serve Man: He doesn't hesitate to use his mandibles and teeth in combat, biting the throat out of a soldier he snares.
- Would Hurt a Child: He was willing to abduct Rory so the Predators could harvest his DNA.