WordGirl / Becky Botsford
Voiced by Dannah PhirmanThe main protagonist of the show. She is from the planet Lexicon, but crashed to Earth as a baby, where she was adopted by the Botsfords. As the 10 year-old superhero WordGirl, she defends Fair City with her superpowers and exceptional vocabulary.
Captain Huggyface / BobAn intelligent chimpanzee who was flying the ship that sent baby WordGirl to Earth. He was adopted into the Botsford family as their pet. He is WordGirl's sidekick.
Voiced by Chris ParnellThe Narrator of the story is able to freely interact with the characters. He is biased toward the heroes so he often assists them by giving advice (for example: telling WordGirl which way the bad guy went).
Doctor Two-Brains / Professor Steven BoxleitnerFreak Lab Accident merged his brain with that of a mouse's, turning him evil.
Theodore "Tobey" McCallister III
Voiced by Patton OswaltA genius 10 year-old boy who terrorizes the city with giant robots. He also has an obsessive crush on WordGirl.
Voiced by Cree SummerA villain who poses as a sweet, deaf old lady but who in actuality is a master thief who specializes in fooling others and convincing everyone to turn against WordGirl.
Voiced by Jack D. FerraioloA large man who dresses like a butcher and has power over meat, which includes conjuring it up and telekinetically controlling it.
Voiced by Edward AsnerThe Butcher's father, who has power over potatoes.
Lady Redundant Woman / Beatrice Bixby
Voiced by Amanda Plummer (first appearance), Grey DeLisleBeatrice Bixby works in a copy shop, and is bitterly jealous of the star employee, Dave. She obsessively cleans and maintains a copy machine, doting on it like it's her child. After curiously pressing a mysterious Big Red Button on the machine, she becomes Lady Redundant Woman and wreaks havoc.
Voiced by Grey DeLisleOne of Lady Redundant Woman's copies, who gained free will and started dating The Butcher, abandoning her mistress. The Butcher gave her her name, and he can easily tell her apart from the original. Sadly, she dumped him and fled the city on a bus. However, she kept a photo of him and seemed to pine for him.
Voiced by Sergio CilliA prince or nobleman from a painting whom Lady Redundant Woman brought to life. He is very greedy and obnoxious, but he calls Lady Redundant Woman "mom" and claims he is her son. He went on a rampage of mischief and destruction throughout Fair City. He made the mistake of breaking the copy machine. Lady Redundant Woman angrily destroyed him.
Evil Malicious WordGirl
Voiced by Dannah PhirmanAn evil copy of WordGirl that Lady Redundant woman created from a picture of her.
Voiced by Grey DeLisleA woman obsessed with questions. She always speaks in the form of a question and she does her best to confuse people to force them to ask questions, usually by spreading chaos. Her lair is very strange, keeping with the theme.
Chuck the Evil Sandwich-Making Guy
Voiced by Fred StollerA man with a sandwich-looking head and an obsession with sandwiches. He lives in his mother's basement and plays video games, but he commits crimes either because he's angry or in an attempt to be cool.
Brent the Handsome Successful Everybody-Loves-Him Sandwich Making Guy
Seymour Orlando Smooth
Voiced by Daran NorrisA man who pretends to be a game show host to scam contestants out of their cash and valuables.
Mr. Big / Shelly Smalls
Voiced by Jeffery TamborA smug businessman who relies on mind control devices to gain the advantage on the competition.
Voiced by Maria BamfordMr. Big's personal assistant, who does most of the heavy lifting in his schemes.
Voiced by Kristen Schaal (speaking), Dev (singing)A child prodigy whose parents expect her to be the best at everything she does.
Voiced by John C. McGinleyA muscle bound man with the power to make powerful sonic booms by bringing his fists together. He inserts "wham" or "whammer" at least once into each sentence. Example: "Wow, that was so whammer!"
Nocan the Contrarian
Voiced by Daran NorrisA barbarian warrior who speaks and acts in opposites, kind of like Bizarro from Superman.
Birthday Girl / Eileen
Voiced by Pamela AldonA greedy little girl who thinks every day is her birthday. She demands that anyone she meets give her things. If she is refused, she will throw a tantrum and grow into a hulking behemoth.
Voiced by John HensonAn annoying waiter who is prone to telling boring stories and then going off on even more boring tangents. He becomes a pirate themed criminal after discovering his power.
Amazing Rope Guy
Voiced by Larry MurphyA villain who's not so much of a villain and more of a fumbling, comic relief character.
Voiced by Jane LynchA new villain introduced in the four-part special "The Rise of Miss Power". She came to Earth, pretending to be a superhero and taking WordGirl under her wing, while preparing to take over.
Voiced by "Weird Al" YankovicA man who can learn anything and devise counter-measures after observing it once. He has a habit of using suffixes twice. For example: "Learnerer" and "adaptinging".
Energy Monster / MariaA creature made of electricity that is driven to absorb electricity and rampage through the city. Eventually, a device made by Dr. Two-Brains allows her to talk and it is revealed that she is female and her name is Maria.
Voiced by Dannah PhirmanA robot created by Tobey in WordGirl's image and programed to be devoted to him. She has all of WordGirl's abilities, but is slightly more powerful.
Voiced by Ryan RaddatzBecky's adoptive father. He's a stay-at-home dad with bizarre mannerisms, and is completely oblivious to his various blunders.
Voiced by Maria BamfordBecky's adoptive mother. She's a district attorney who prosecutes criminals.
Voiced by Maria BamfordBecky's best friend. She's a talented artist and poet and has a tedious grasp on reality.
Todd "Scoops" Ming
Voiced by Ryan RaddatzA boy who runs the school newspaper, and the object of Becky's affections.
Voiced by Chris ParnellA man with no real purpose besides moving the plot along by running up screaming for help, alerting WordGirl to a crime or disaster. He constantly mistakes random places for the police station. According to "Scary with a Side of Butter", he sets his watch ahead so he can be the first to panic.